AIM: To evaluate the preliminary effects of comprehensive prevention of gastric cancer in Zhuanghe County epidemiologically.METHODS: Stratified sampling and cluster sampling were applied to define the intervention gro...AIM: To evaluate the preliminary effects of comprehensive prevention of gastric cancer in Zhuanghe County epidemiologically.METHODS: Stratified sampling and cluster sampling were applied to define the intervention group and the control group. The prospective cohort study was used for evaluating the effect of preventing gastric cancer. The relative risk (RR)and attributable risk percent (AR %) of intervention on gastric cancer death were calculated. Potential years of life lost (PLYY) of the disease was analyzed, and the RR and AR %of PYLL were calculated. Survival analysis was applied among the screened patients.RESULTS: In the first 4 years after intervening, the relative risk (RR) of intervention on death was 0.5059 (95 % CI:0.3462～0.7392,P＜0.05) with significance statistically. AR %of the intervention on death was 49.41%. The RR of intervention on cumulative PYLL was 0.6778 (95 % CI:0.5604～0.8198,P＜0.05) with statistic significance. AR %of the intervention on cumulative PYLL was 30.32 %. The four-year survival rate of the screened patients was 0.6751(95 % CI: 0.5298～0.9047).CONCLUSION: The initiative intervention results showed that the intervention approach used in the trial was effective, it reduced mortality and increased survival rate, and alleviated the adverse effect of gastric cancer on the health and life of screened population.展开更多
The photocleavage abilities of a novel family of compounds, 8-oxo-8%H%-acenaphtho pyrrole-9-carbonitrile and its derivatives(compounds 1—5) were evaluated with M13 mp18 single strand circular DNA. Only compound 1 wit...The photocleavage abilities of a novel family of compounds, 8-oxo-8%H%-acenaphtho pyrrole-9-carbonitrile and its derivatives(compounds 1—5) were evaluated with M13 mp18 single strand circular DNA. Only compound 1 with a diethylamine group could bind to DNA %via% electrostatic attraction and intercalation. At a concentration of 50 μmol/L, it could generate singlet oxygen to cleave circular DNA into linear DNA under the irradiation of long wavelength light(λ>400 nm). The antitumor {ability} of compound 1 was also evaluated in vitro, and its IC_ 50 on HeLa cells was as low as 6.8 μmol/L.展开更多
Purpose:To determine the mechanism of nerve fiber damage in glaucoma by studing the structure of hu-man optic nerve lamina cribrosa(LC)in different regions.Methods:15 human eyes of 10cases were stuided.The specimens w...Purpose:To determine the mechanism of nerve fiber damage in glaucoma by studing the structure of hu-man optic nerve lamina cribrosa(LC)in different regions.Methods:15 human eyes of 10cases were stuided.The specimens were prepared for scanning electron microscopy,and numbers and areas of pores in LC were measured by electron image analysis system.Draw a frequency distribution map with each curve represents the tendency of pores distribution in a particular part.The proportion of the connective tissue in respective quadrant can also be calcu-lated.The specimens were also prepared for histological examination.Results:There are many pores of various magnitude and shapes on the surface of LC.There are significantly more large pores(≥3000μm^2)in the superior and in-ferior than those in the nasal and temporal quadrants,especially in the peripheral regions,In terms of area,the percentages of connective tissue in the nasal and temporal quadrants are the highest.Collageous fibers,various in diameter,are arranged in bundles and tangentially around each pore.Conclusion:In normal persons,the percentage of large pores in the superior and inferior peripheral parts is the highest,the density of the connective tissue is the lowest.So,the force received by unit area of the superior and inferior parts is bigger than that of the nasal and temporal sides.therefore,it is susceptible to the impact of high intraocular pressure at the early stage and causing correspond-ing visual edfect.Our study may suggest the mechanism of optic nerve damage of glaucoma,Eye Science 1995;11:147-154.展开更多
基金National Ninth Five-year Study Program for Taking Key Scientific Problems,No.96-906-01-04National Tenth Fiveyear Study Program for Taking Key Scientific Problems,No.2001BA703B06(B)
文摘AIM: To evaluate the preliminary effects of comprehensive prevention of gastric cancer in Zhuanghe County epidemiologically.METHODS: Stratified sampling and cluster sampling were applied to define the intervention group and the control group. The prospective cohort study was used for evaluating the effect of preventing gastric cancer. The relative risk (RR)and attributable risk percent (AR %) of intervention on gastric cancer death were calculated. Potential years of life lost (PLYY) of the disease was analyzed, and the RR and AR %of PYLL were calculated. Survival analysis was applied among the screened patients.RESULTS: In the first 4 years after intervening, the relative risk (RR) of intervention on death was 0.5059 (95 % CI:0.3462～0.7392,P＜0.05) with significance statistically. AR %of the intervention on death was 49.41%. The RR of intervention on cumulative PYLL was 0.6778 (95 % CI:0.5604～0.8198,P＜0.05) with statistic significance. AR %of the intervention on cumulative PYLL was 30.32 %. The four-year survival rate of the screened patients was 0.6751(95 % CI: 0.5298～0.9047).CONCLUSION: The initiative intervention results showed that the intervention approach used in the trial was effective, it reduced mortality and increased survival rate, and alleviated the adverse effect of gastric cancer on the health and life of screened population.
文摘The photocleavage abilities of a novel family of compounds, 8-oxo-8%H%-acenaphtho pyrrole-9-carbonitrile and its derivatives(compounds 1—5) were evaluated with M13 mp18 single strand circular DNA. Only compound 1 with a diethylamine group could bind to DNA %via% electrostatic attraction and intercalation. At a concentration of 50 μmol/L, it could generate singlet oxygen to cleave circular DNA into linear DNA under the irradiation of long wavelength light(λ>400 nm). The antitumor {ability} of compound 1 was also evaluated in vitro, and its IC_ 50 on HeLa cells was as low as 6.8 μmol/L.
文摘Purpose:To determine the mechanism of nerve fiber damage in glaucoma by studing the structure of hu-man optic nerve lamina cribrosa(LC)in different regions.Methods:15 human eyes of 10cases were stuided.The specimens were prepared for scanning electron microscopy,and numbers and areas of pores in LC were measured by electron image analysis system.Draw a frequency distribution map with each curve represents the tendency of pores distribution in a particular part.The proportion of the connective tissue in respective quadrant can also be calcu-lated.The specimens were also prepared for histological examination.Results:There are many pores of various magnitude and shapes on the surface of LC.There are significantly more large pores(≥3000μm^2)in the superior and in-ferior than those in the nasal and temporal quadrants,especially in the peripheral regions,In terms of area,the percentages of connective tissue in the nasal and temporal quadrants are the highest.Collageous fibers,various in diameter,are arranged in bundles and tangentially around each pore.Conclusion:In normal persons,the percentage of large pores in the superior and inferior peripheral parts is the highest,the density of the connective tissue is the lowest.So,the force received by unit area of the superior and inferior parts is bigger than that of the nasal and temporal sides.therefore,it is susceptible to the impact of high intraocular pressure at the early stage and causing correspond-ing visual edfect.Our study may suggest the mechanism of optic nerve damage of glaucoma,Eye Science 1995;11:147-154.
