The Key Laboratory of Coastal Wetland Biogeosciences (KLCWB) was established in August 2012 and is incorporated into the Qingdao Institute of Marine Geology, China Geological Survey, Ministry of Natural Resources. The...The Key Laboratory of Coastal Wetland Biogeosciences (KLCWB) was established in August 2012 and is incorporated into the Qingdao Institute of Marine Geology, China Geological Survey, Ministry of Natural Resources. The KLCWB focus on the frontiers of international coastal wetland biogeology science and technology development, especially the hot topics in biological geology, environmental geology and ecological resources.展开更多
The present study investigated the effects of varying protein source combinations and feeding strategies on the growth,health and organoleptic quality of the large yellow croaker(Larimichthys crocea).Three iso-nitroge...The present study investigated the effects of varying protein source combinations and feeding strategies on the growth,health and organoleptic quality of the large yellow croaker(Larimichthys crocea).Three iso-nitrogenous and iso-lipidic diets were formulated.The control diet was made with 62%fish meal(FM).The other two experimental diets were formulated by replacing 45%FM with 22.5%mealworm(TM)and 22.5%cottonseed protein concentrate(CPC),or with 22.5%TM and 22.5%Clostridium autoethanogenum protein(CAP),respectively.The three kinds of diet were named as A1,A2 and A3,respectively.Five groups of large yellow croaker were fed with two different strategies:the first three groups were continuously fed with A1,A2 and A3 diets,respectively.The fourth group was alternately fed with A1 and A2 diet every 5 days.The fifth group was alternately fed with A1 and A3diet every 5 days.The five groups were named D1,D2,D3,D1-2 and D1-3,respectively.Results showed that D2 and D3 groups exhibited significantly lower weight gain rate(WGR)and higher feed conversion ratios(FCR)compared to the D1 group.The D1-2 and D1-3 groups exhibited improved WGR and significantly reduced FCR compared to the D2 and D3 groups.The A2 and A3 diets significantly suppressed digestive enzymes'activities compared to A1,whereas alternate-feeding groups significantly enhanced the enzyme activities.Compared to the D1 group,D2 and D3 groups significantly downregulated mRNA expression levels of intestinal antiinflammatory cytokines and upregulated the expression of pro-inflammatory mediators.The anti-inflammatory abilities in the D1-2and D1-3 groups were significantly higher than those in the D2 and D3 groups.Additionally,diets containing TM+CAP and TM+CPC protein sources enhanced ventral redness and yellowness indices.Considering the growth,digestion,immunity and organoleptic quality of large yellow croaker,it is recommended to replace up to 45%of FM with TM+CPC and use an alternate-feeding strategy.展开更多
Porous carbon microspheres are widely regarded as a superior CO_(2) adsorbent due to their exceptional efficiency and affordability.However,better adsorption performance is very attractive for porous carbon microspher...Porous carbon microspheres are widely regarded as a superior CO_(2) adsorbent due to their exceptional efficiency and affordability.However,better adsorption performance is very attractive for porous carbon microspheres.And modification of the pore structure is one of the effective strategies.In this study,multi-cavity mesoporous carbon microspheres were successfully synthesized by the synergistic method of soft and hard templates,during which a phenolic resin with superior thermal stability was employed as the carbon precursor and a mixture of silica sol and F108 as the mesoporous template.Carbon microspheres with multi-cavity mesoporous structures were prepared,and all the samples showed highly even mesopores,with diameters around 12 nm.The diameter of these microspheres decreased from 396.8 nm to about 182.5 nm with the increase of silica sol.After CO_(2) activation,these novel carbon microspheres(APCF0.5-S1.75)demonstrated high specific surface area(983.3 m^(2)/g)and remarkable CO_(2) uptake of 4.93 mmol/g at 0℃ and1 bar.This could be attributed to the unique multi-cavity structure,which offers uniform mesoporous pore channels,minimal CO_(2) transport of and a greater number of active sites for CO_(2) adsorption.展开更多
Heat stress reduces theanine content in tea plants,but the underlying molecular mechanism remains unclear.In this study,a temperature gradient treatment(20℃,25℃,30℃,and 35℃)was performed to unveil the effect of he...Heat stress reduces theanine content in tea plants,but the underlying molecular mechanism remains unclear.In this study,a temperature gradient treatment(20℃,25℃,30℃,and 35℃)was performed to unveil the effect of heat stress on biosynthesis and accumulation of theanine.We found that heat stress induced metabolic changes,characterized by decreased theanine content and increased catechin levels.In addition,heat stress up-regulated the expression of the class B heat shock transcription factor gene CsHSFB2c,while significantly suppressing the transcription of key theanine biosynthetic genes CsTS1 and CsGS1.Functional studies showed that silencing CsHSFB2c increased theanine content,while its overexpression significantly decreased theanine levels.Consistent with these changes,silencing CsHSFB2c upregulated the expression of CsTS1 and CsGS1,while overexpression of CsHSFB2c downregulated their expression.Yeast one-hybrid(Y1H)and dual-luciferase reporter gene(Dual-LUC)assays showed that CsHSFB2c directly binds to the promoters of CsTS1 and CsGS1 and inhibits their expression.These results demonstrate that CsHSFB2c mediates heat-induced suppression of theanine biosynthesis by directly inhibiting the expression of CsTS1 and CsGS1.This study provides a theoretical basis for improving the heat resistance and quality of tea plants via molecular breeding.展开更多
Current pharmacotherapies for Alzheimer's disease(AD)exhibit constrained transient symptomatic relief without halting underlying neurodegenerative progression.Based on the framework of the amyloid cascade and neur...Current pharmacotherapies for Alzheimer's disease(AD)exhibit constrained transient symptomatic relief without halting underlying neurodegenerative progression.Based on the framework of the amyloid cascade and neurofibrillary tangle hypotheses[1],two FDA-approved antiamyloid monoclonal antibodies(Aβ-mAbs),Kisunla and Lecanemab,have demonstrated efficacy in removing cerebral amyloid buildup,thereby modestly slowing cognitive decline in AD patients[2,3].A 2023 meta-analysis in Neurology demonstrated that anti-amyloid therapies significantly accelerated brain volume loss compared to placebo,with Lecanemab demonstrating 36.4%greater volume reduction and Donanemab 23%.展开更多
Aleuropteryx sinica Liu&Yang,2003 is the only species of Aleuropteryx in the family Coniopterygidae found in China.In this study,we used high-throughput sequencing methods to assemble the complete mitochondrial ge...Aleuropteryx sinica Liu&Yang,2003 is the only species of Aleuropteryx in the family Coniopterygidae found in China.In this study,we used high-throughput sequencing methods to assemble the complete mitochondrial genome of A.sinica.The results showed that the complete mitogenome is 15,600 bp in length and had a high AT content(76.30%),with a typical set of 37 genes,including 13 protein-coding genes(PCGs),22 transfer RNA genes(tRNAs),2 ribosomal RNA genes(rRNAs),and 1 control region(CR)Based on the sequences of 13PCGs+2rRNAs,the phylogenetic analysis revealed that A.sinica,Coniopteryx sp.,Conwentzia sinica Yang,1974,Semidalis macleodi Meinander,1972 and Semidalis aleyrodiformis Stephens,1836 form a clade,which is a sister group to other families of Neuroptera.展开更多
Background:Glioblastoma(GBM)prognosis has seen little improvement over the past two decades.While immunotherapy has revolutionized cancer treatment,its impact on GBM remains limited.To characterize the evolving resear...Background:Glioblastoma(GBM)prognosis has seen little improvement over the past two decades.While immunotherapy has revolutionized cancer treatment,its impact on GBM remains limited.To characterize the evolving research landscape and identify future directions in GBM immunotherapy,we conducted a comprehensive bibliometric review.Methods:All literature related to immunotherapy in GBM from 1999 to 2024 was collected from the Web of Science Core Collection.CtieSpace and VOSviewer were used to conduct bibliometric analysis and visualize the data.Results:Bibliometric analysis identified 5038 publications authored by 23,335 researchers from 4699 institutions across 96 countries/regions,published in 945 journals.The United States produced the highest number of publications,while Switzerland achieved the highest average citation rate.Duke University led in institutional output and citations.John H Sampson was the most productive author,and Roger Stupp was the most cited.Frontiers in Immunology published the most papers,while Clinical Cancer Research was the most cited journal.Research focus centered on adoptive T cell therapy,particularly chimeric antigen receptor(CAR)-T cells with 572 dedicated publications.Within CAR-T research for GBM,the University of Pennsylvania was the leading institution,Frontiers in Immunology the predominant journal,and Christine E Brown(City of Hope National Medical Center)was the most prolific and cited author.Conclusions:There has been a growing interest in GBM immunotherapy over past decades.The United States is the dominant contributor.CAR-T therapy represents the primary research focus.Emerging strategies like chimeric antigen receptor-modified natural killer(CAR-NK)cells,chimeric antigen receptor-engineered macrophages(CAR-M),and cytomegalovirus-specific T cell receptor(CMV-TCR)T cells are gaining prominence,aiming to address limitations in antigen recognition inherent to CAR-T therapy for GBM.展开更多
The recovery of precious metals(PMs)from secondary resources is critical for addressing global supply-chain vulnerabilities and sustainable resource utilization.This review systematically examines the transformative p...The recovery of precious metals(PMs)from secondary resources is critical for addressing global supply-chain vulnerabilities and sustainable resource utilization.This review systematically examines the transformative potential of metal-organic frameworks(MOFs)as next-generation adsorbents for PM recovery,focusing on their synthesis,functionalization,and multiscale adsorption mechanisms.We critically analyze conventional pyrometallurgical and hydrometallurgical methods and highlight their limitations in terms of selectivity,energy consumption,and secondary pollution.In contrast,MOFs offer tunable porosity,abundant active sites,and tunable surface chemistry,enabling efficient PM capture via synergistic physical and chemical adsorption.Advanced modification techniques,including direct synthesis and post-synthetic modification,are reviewed to propose strategies for enhancing the adsorption kinetics and selectivity for Au,Ag,Pt,and Pd.Key structure-property relationships are established through multiscale characterization and thermodynamic models,revealing the critical roles of hierarchical porosity,soft donor atoms,and framework stability.Industrial challenges,such as aqueous stability and scalability,are addressed via Zr-O bond strengthening,hydrophobic functionalization,and support immobilization.This study consolidates the experimental and theoretical advances in MOF-based PM recovery and provides a roadmap for translating laboratory innovations into practical applications within the circular-economy framework.展开更多
To enhance the anesthetic efficacy of propofol while mitigating its systemic toxicity and irreversible developmental neurotoxicity, we developed a strategy leveraging the neuroprotective effects of baicalin in combina...To enhance the anesthetic efficacy of propofol while mitigating its systemic toxicity and irreversible developmental neurotoxicity, we developed a strategy leveraging the neuroprotective effects of baicalin in combination with propofol anesthesia via baicalinbased nanocomposites. High propofol-loaded porous Baicalin-Fe(Ⅲ) infinite coordination polymer@propofol nanocomposites were synthesized, wherein baicalin coordinates with Fe3+ ions to form porous nanoparticles that encapsulate propofol within a core-shell structure. These nanocomposites exhibited an average diameter of 92.3 ± 10.2 nm and a pore volume of 0.322 cm^(3)/g, achieving ultra-high propofol loading(~62%) with no detectable leakage over 100 d, attributed to their large surface area and strong molecular interactions.When combined with focused ultrasound(FUS) and microbubbles, the effective dose(ED_(50))of propofol decreased from 10 to 4.3 mg/kg, doubling the duration of anesthesia and extending the therapeutic window by 200%. Importantly, the therapeutic index improved1.66-fold while vital physiological parameters remained stable. Histological analyses revealed an 80% reduction in neuronal injury compared to free propofol, and behavioral tests demonstrated significant enhancements in motor and cognitive performance, alongside recovery from propofol-induced irreversible developmental neurotoxicity, indicating effective neuroprotection. Collectively, this baicalin-propofol nanocomposite, coupled with FUS-mediated delivery, represents a promising approach for safe and long-term anesthesia in clinical applications.展开更多
Tactile feedback is critical for human interaction with external information.Similarly,tactile feedback can enrich the user's sensations when using prosthesis.To explore a potential scheme for tactile feedback,thi...Tactile feedback is critical for human interaction with external information.Similarly,tactile feedback can enrich the user's sensations when using prosthesis.To explore a potential scheme for tactile feedback,this study applied a non-inva-sive Transcutaneous Electrical Nerve Stimulation(TENS)to elicit tactile sensations in the hand,which involved median nerve,ulnar nerve,and radial nerve.Ten able-bodied subjects(8 males,2 females)were recruited to participate in the study.An array of 4×2 electrodes was positioned on the medial aspect of the brachii muscle's short head in the upper arm,which is in proximity to the median nerve,ulnar nerve,and radial nerve.Different electrode pairs were randomly selected to elicit distinct sensations at various positions on the hand,and the subjects reported the sensory areas.Then,the sensory areas and sensory thresholds were confirmed through psychophysical methods.According to the experimental results,tactile sensations were elicited at different locations on the subjects'hand through TENS of different electrode pairs.All subjects reported extensive and detailed sensory areas in the fingers,palm,and dorsum,corresponding to the sensory innervation areas of different nerves.The study effectively demonstrated the ability of TENS in evoking tactile feedback in the hand,paving the way for future optimization and development of prosthetic hands.展开更多
α-Chiral amides are common in pharmaceuticals,agrochemicals,natural products,and peptides,prompting the need for new synthetic methods.Here,we introduce a nickel-catalyzed asymmetric reductive amidation method to syn...α-Chiral amides are common in pharmaceuticals,agrochemicals,natural products,and peptides,prompting the need for new synthetic methods.Here,we introduce a nickel-catalyzed asymmetric reductive amidation method to synthesizeα-chiral amides from benzyl ammonium salts and isocyanates.The key to success is using a chiral 2,2-bipyridine ligand(-)-Ph-SBpy,enabling high yield(up to 95%)and enantiomeric ratio(up to 98:2 er)under mild conditions.Addition of phenol prevents isocyanate polymerization by reversibly forming a carbamate intermediate,enhancing selectivity and efficiency.The synthetic utility is showcased through transformations of the enantioenriched amides,and the mechanism and enantioselectivity are supported by experimental and computational studies.展开更多
The Northeast China Cold Vortex(NCCV)is a common cut-off low-pressure system in Northeast China,frequently causing localized heavy rainfall,strong winds,and thunderstorms during the early summer.In this study,the clea...The Northeast China Cold Vortex(NCCV)is a common cut-off low-pressure system in Northeast China,frequently causing localized heavy rainfall,strong winds,and thunderstorms during the early summer.In this study,the clear-sky radiance of 48 longwave channels from the FY-4B Geostationary Interferometric Infrared Sounder(GIIRS)is assimilated into the China Meteorological Administration mesoscale model(CMA-MESO)to evaluate its impact on NCCV development and its effects on rainfall forecasting.The results show that after assimilating the GIIRS radiance data,the warm center at 200 hPa and the cold center at 850 hPa of the NCCV are strengthened,and the dry intrusion at 850 hPa becomes more pronounced.This leads to a stronger NCCV intensity in the following 24 hours and brings the precipitation intensity and area closer to the observation,resulting in significant improvements compared to the experiments that do not assimilate GIIRS radiance data.Furthermore,it is found that the enhancement of the precipitation forecast is associated with the strengthening of cold air in the middle and lower troposphere,which intensifies the uplift of the warm,moist airflow.These results highlight the potential value of GIIRS data assimilation in enhancing early warnings and forecasts of extreme weather events influenced by the NCCV.展开更多
Smart windows that can repel diverse liquids are highly attractive for the development of self-cleaning building system.Despite immense achievements having been made in drophobic smart windows,unfortunately,the limita...Smart windows that can repel diverse liquids are highly attractive for the development of self-cleaning building system.Despite immense achievements having been made in drophobic smart windows,unfortunately,the limitations of inferior transparency,unsatisfactory flexibility,and scarce functionality greatly hinder their practical applications.Here,a multifunctional,all-flexible and slef-cleaning electrothermal-actuated(SETA)module with superior transparency is developed by sandwiching the hydrophobic SiO_(2) nanoparticles decorated silver nanowires thin-film heater and the thermo-responsive hydrogel.Through loading/discharging an electric stimulus of 5 V,the optical visibility of SETA could be in situ switched between an opaque state(T_(550)=11.0%)and a transparent state(T_(550)=84.9%)relying on the dynamically collapsed and swollen transition of hydrogel on planar and three-dimensional curved surfaces.Moreover,SETA chipset is able to repel diverse liquids,including organic and inorganic species,showcasing an excellent self-cleaning capability.Lastly,all-in-one multifunctionalities,including pixelated display,thermal regulation,defogging,and self-cleaning on a single SETA chipset,are successfully deployed.Compared to the previous windows,the current SETA chipset is more competent for optical switching in reality,owing to its portable,energy-efficient,flexible,highly-transparent,and on-demand manipulating advantages.This work provides inspirations for self-cleaning greenhouse,tunable optics,intelligent vehicles,and so on.展开更多
Acute pancreatitis(AP)is sudden inflammation of the pancreas,which can lead to multiple organ dysfunction in severe cases.Hypertriglyceridemia(HTG)is the third most common cause.In recent years,HTG-induced AP(HTG-AP)h...Acute pancreatitis(AP)is sudden inflammation of the pancreas,which can lead to multiple organ dysfunction in severe cases.Hypertriglyceridemia(HTG)is the third most common cause.In recent years,HTG-induced AP(HTG-AP)has garnered increasing attention.Compared to AP caused by other causes,HTG-AP often has a more subtle onset but is more likely to progress to a severe,critical illness that poses a serious threat to a patient’s life and health.Research suggests a potential connection between the gut microbiota and AP,which could be mediated by bacterial metabolites,immune cells,and inflammatory factors.This is supported by observations of microbial imbalance and higher intestinal permeability in patients with AP.In addition,studies have shown that HTG-induced changes in gut microbiota can worsen AP by negatively impacting the host metabolism,immune response,and function of the intestinal barrier.In this review,we summarize recent clinical and animal studies on the role and mechanism of gut microbiota in the severity of AP aggravated by HTG.The application prospects of the newly proposed microbial-host-isozyme concept are summarized,focusing on its potential for the precision diagnosis and treatment of HTG-AP through gut microbiota regulation.展开更多
Amid accelerating global land degradation,establishing high-efficiency ecological restoration principles and frameworks is crucial.Here,we explore the application of threshold effects in the ecological restoration pro...Amid accelerating global land degradation,establishing high-efficiency ecological restoration principles and frameworks is crucial.Here,we explore the application of threshold effects in the ecological restoration process based on field experiments and globally available experimental data from 173 sites.Combining data integration analysis and meta-analysis,we collectively verified the universality of threshold effects in grasslands.The global grasslands’average nitrogen application threshold is 3.78 g·m^(-2)·yr^(−1),while the threshold value of degraded grassland(3.65 g·m^(-2)·yr^(−1))is lower than that of nondegraded grassland(5.90 g·m^(-2)·yr^(−1)).The low nitrogen-driven thresholds are affected by degradation status,climate(precipitation and temperature),and other site conditions,but not fertilization forms.Independent experiments further demonstrated that an increase in soil moisture content can lead to the disappearance of nitrogen threshold effects,revealing that ecological threshold effects are influenced by ecosystem stress factors.Following the significant increase in plant biomass triggered by the nitrogen threshold,the ecosystem undergoes systemic improvement.Soil organic carbon,urease activity,soil microbial diversity,and other soil properties are significantly enhanced.Soil nitrogen cycle-related microbial communities and soil physicochemical attributes are significantly activated.The results indicate that a threshold response pattern may develop before nitrogen saturation is reached,and low nitrogen input can boost productivity and improve the plant-soil-microbe system.Our findings reveal a nonprogressive path of restoration in degraded ecosystems,and thus,restoration based on threshold effects can offer an efficient and safe solution to combat ecological degradation.展开更多
The surface species of CO hydrogenation on CeO2-Co/SiO2 catalyst were investigated using the techniques of temperature programmed reaction and transient response method. The results indicated that the formation of H2O...The surface species of CO hydrogenation on CeO2-Co/SiO2 catalyst were investigated using the techniques of temperature programmed reaction and transient response method. The results indicated that the formation of H2O and CO2 was the competitive reaction for the surface oxygen species, CH4 was produced via the hydrogenation of carbon species step by step, and C2 products were formed by the polymerization of surface-active carbon species （-CH2-）. Hydrogen assisted the dissociation of CO. The hydrogenation of surface carbon species was the rate-limiting step in the hydrogenation of CO over CeO2-Co/SiO2 catalyst. The investigation of total pressure, gas hourly space velocity （GHSV）, and product distribution using nitrogen-rich synthesis gas as feedstock over a laboratory scale fixed-bed reactor indicated that total pressure and GHSV had a significant effect on the catalytic performance of CeO2-Co/SiO2 catalyst. The removal of heat and control of the reaction temperature were extremely critical steps, which required lower GHSV and appropriate CO conversion to avoid the deactivation of the catalyst. The feedstock of nitrogen-rich synthesis gas was favorable to increase the conversion of CO, but there was a shift of product distribution toward the light hydrocarbon. The nitrogen-rich synthesis gas was feasible for F-T synthesis for the utilization of remote natural gas.展开更多
Metastasis is the main cause of cancer mortality. One of the initiating events of cancer metastasis of epithelial tumors is epithelial-to-mesenchymal transition(EMT), during which cells dedifferentiate from a relative...Metastasis is the main cause of cancer mortality. One of the initiating events of cancer metastasis of epithelial tumors is epithelial-to-mesenchymal transition(EMT), during which cells dedifferentiate from a relatively rigid cell structure/morphology to a flexible and changeable structure/morphology often associated with mesenchymal cells. The presence of EMT in human epithelial tumors is reflected by the increased expression of genes and levels of proteins that are preferentially present in mesenchymal cells. The combined presence of these genes forms the basis of mesenchymal gene signatures, which are the foundation for classifying a mesenchymal subtype of tumors. Indeed, tumor classification schemes that use clustering analysis of large genomic characterizations, like The Cancer Genome Atlas(TCGA), have defined mesenchymal subtype in a number of cancer types, such as high-grade serous ovarian cancer and glioblastoma. However, recent analyses have shown that gene expression-based classifications of mesenchymal subtypes often do not associate with poor survival. This "paradox" can be ameliorated using integrated analysis that combines multiple data types. We recently found that integrating m RNA and micro RNA(mi RNA) data revealed an integrated mesenchymal subtype that is consistently associated with poor survival in multiple cohorts of patients with serous ovarian cancer. This network consists of 8 major mi RNAs and 214 m RNAs. Among the 8 mi RNAs, 4 are known to be regulators of EMT. This review provides a summary of these 8 mi RNAs, which were associated with the integrated mesenchymal subtype of serous ovarian cancer.展开更多
Key frame extraction based on sparse coding can reduce the redundancy of continuous frames and concisely express the entire video.However,how to develop a key frame extraction algorithm that can automatically extract ...Key frame extraction based on sparse coding can reduce the redundancy of continuous frames and concisely express the entire video.However,how to develop a key frame extraction algorithm that can automatically extract a few frames with a low reconstruction error remains a challenge.In this paper,we propose a novel model of structured sparse-codingbased key frame extraction,wherein a nonconvex group log-regularizer is used with strong sparsity and a low reconstruction error.To automatically extract key frames,a decomposition scheme is designed to separate the sparse coefficient matrix by rows.The rows enforced by the nonconvex group log-regularizer become zero or nonzero,leading to the learning of the structured sparse coefficient matrix.To solve the nonconvex problems due to the log-regularizer,the difference of convex algorithm(DCA)is employed to decompose the log-regularizer into the difference of two convex functions related to the l1 norm,which can be directly obtained through the proximal operator.Therefore,an efficient structured sparse coding algorithm with the group log-regularizer for key frame extraction is developed,which can automatically extract a few frames directly from the video to represent the entire video with a low reconstruction error.Experimental results demonstrate that the proposed algorithm can extract more accurate key frames from most Sum Me videos compared to the stateof-the-art methods.Furthermore,the proposed algorithm can obtain a higher compression with a nearly 18% increase compared to sparse modeling representation selection(SMRS)and an 8% increase compared to SC-det on the VSUMM dataset.展开更多
This study reported two new species:Newsteadia multipori Zheng&Wu,sp.nov.,collected from pine needle litter in Guizhou Province,are described and illustrated for its adult female,male,and first-,second-and third-i...This study reported two new species:Newsteadia multipori Zheng&Wu,sp.nov.,collected from pine needle litter in Guizhou Province,are described and illustrated for its adult female,male,and first-,second-and third-instar nymphs;N.chebalingensis Zheng&Wu,sp.nov.,collected from broad leaf litter in Guangdong Province,are described and illustrated for its adult female and first-instar nymph.Identification keys are provided to the adult females of Newsteadia species known in China and to the adult males of Newsteadia species known worldwide.展开更多
Rhesus monkey models of Parkinson＇s disease were induced by injection of N-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine. Neural firings were recorded using microelectrodes placed in the interna segment of the globus p...Rhesus monkey models of Parkinson＇s disease were induced by injection of N-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine. Neural firings were recorded using microelectrodes placed in the interna segment of the globus pallidus. The wavelets and power spectra show gradual power reduction during the disease process along with increased firing rates in the Parkinson＇s disease state. Singular values of coefficients decreased considerably during tremor-related activity as well as in the Parkinson＇s disease state compared with normal signals, revealing that higher-frequency components weaken when Parkinson＇s disease occurs. We speculate that the death of neurons could be reflected by irregular frequency spike trains, and that wavelet packet decomposition can effectively detect the degradation of neurons and the loss of information transmission in the neural circuitry.展开更多
文摘The Key Laboratory of Coastal Wetland Biogeosciences (KLCWB) was established in August 2012 and is incorporated into the Qingdao Institute of Marine Geology, China Geological Survey, Ministry of Natural Resources. The KLCWB focus on the frontiers of international coastal wetland biogeology science and technology development, especially the hot topics in biological geology, environmental geology and ecological resources.
基金financially supported by the Key Research and Development Program of Shandong,China(No.2021SFGC0701)。
文摘The present study investigated the effects of varying protein source combinations and feeding strategies on the growth,health and organoleptic quality of the large yellow croaker(Larimichthys crocea).Three iso-nitrogenous and iso-lipidic diets were formulated.The control diet was made with 62%fish meal(FM).The other two experimental diets were formulated by replacing 45%FM with 22.5%mealworm(TM)and 22.5%cottonseed protein concentrate(CPC),or with 22.5%TM and 22.5%Clostridium autoethanogenum protein(CAP),respectively.The three kinds of diet were named as A1,A2 and A3,respectively.Five groups of large yellow croaker were fed with two different strategies:the first three groups were continuously fed with A1,A2 and A3 diets,respectively.The fourth group was alternately fed with A1 and A2 diet every 5 days.The fifth group was alternately fed with A1 and A3diet every 5 days.The five groups were named D1,D2,D3,D1-2 and D1-3,respectively.Results showed that D2 and D3 groups exhibited significantly lower weight gain rate(WGR)and higher feed conversion ratios(FCR)compared to the D1 group.The D1-2 and D1-3 groups exhibited improved WGR and significantly reduced FCR compared to the D2 and D3 groups.The A2 and A3 diets significantly suppressed digestive enzymes'activities compared to A1,whereas alternate-feeding groups significantly enhanced the enzyme activities.Compared to the D1 group,D2 and D3 groups significantly downregulated mRNA expression levels of intestinal antiinflammatory cytokines and upregulated the expression of pro-inflammatory mediators.The anti-inflammatory abilities in the D1-2and D1-3 groups were significantly higher than those in the D2 and D3 groups.Additionally,diets containing TM+CAP and TM+CPC protein sources enhanced ventral redness and yellowness indices.Considering the growth,digestion,immunity and organoleptic quality of large yellow croaker,it is recommended to replace up to 45%of FM with TM+CPC and use an alternate-feeding strategy.
基金supported by the National Key R&D Program of China(No.2021YFB3501102).
文摘Porous carbon microspheres are widely regarded as a superior CO_(2) adsorbent due to their exceptional efficiency and affordability.However,better adsorption performance is very attractive for porous carbon microspheres.And modification of the pore structure is one of the effective strategies.In this study,multi-cavity mesoporous carbon microspheres were successfully synthesized by the synergistic method of soft and hard templates,during which a phenolic resin with superior thermal stability was employed as the carbon precursor and a mixture of silica sol and F108 as the mesoporous template.Carbon microspheres with multi-cavity mesoporous structures were prepared,and all the samples showed highly even mesopores,with diameters around 12 nm.The diameter of these microspheres decreased from 396.8 nm to about 182.5 nm with the increase of silica sol.After CO_(2) activation,these novel carbon microspheres(APCF0.5-S1.75)demonstrated high specific surface area(983.3 m^(2)/g)and remarkable CO_(2) uptake of 4.93 mmol/g at 0℃ and1 bar.This could be attributed to the unique multi-cavity structure,which offers uniform mesoporous pore channels,minimal CO_(2) transport of and a greater number of active sites for CO_(2) adsorption.
基金supported by the Major Project of Guizhou Provincial Science and Technology Program,China([2024]027)the High-Level Innovative Talents Project of Guizhou Province,China(GCC[2023]014)+1 种基金the Guizhou Provincial Tea Industry Technology System,China(GZCYCYJSTX-03)the Science and Technology Project of China Huaneng Group(HNKJ2022-H135)。
文摘Heat stress reduces theanine content in tea plants,but the underlying molecular mechanism remains unclear.In this study,a temperature gradient treatment(20℃,25℃,30℃,and 35℃)was performed to unveil the effect of heat stress on biosynthesis and accumulation of theanine.We found that heat stress induced metabolic changes,characterized by decreased theanine content and increased catechin levels.In addition,heat stress up-regulated the expression of the class B heat shock transcription factor gene CsHSFB2c,while significantly suppressing the transcription of key theanine biosynthetic genes CsTS1 and CsGS1.Functional studies showed that silencing CsHSFB2c increased theanine content,while its overexpression significantly decreased theanine levels.Consistent with these changes,silencing CsHSFB2c upregulated the expression of CsTS1 and CsGS1,while overexpression of CsHSFB2c downregulated their expression.Yeast one-hybrid(Y1H)and dual-luciferase reporter gene(Dual-LUC)assays showed that CsHSFB2c directly binds to the promoters of CsTS1 and CsGS1 and inhibits their expression.These results demonstrate that CsHSFB2c mediates heat-induced suppression of theanine biosynthesis by directly inhibiting the expression of CsTS1 and CsGS1.This study provides a theoretical basis for improving the heat resistance and quality of tea plants via molecular breeding.
基金supported by the Research Personnel Cultivation Programme of Zhongda Hospital Southeast(CZXM-GSP-RC172)the Science and Technology Innovation 2030 Major Projects(2022ZD0211600)the National Natural Science Foundation of China(82271574 and 82502335).
文摘Current pharmacotherapies for Alzheimer's disease(AD)exhibit constrained transient symptomatic relief without halting underlying neurodegenerative progression.Based on the framework of the amyloid cascade and neurofibrillary tangle hypotheses[1],two FDA-approved antiamyloid monoclonal antibodies(Aβ-mAbs),Kisunla and Lecanemab,have demonstrated efficacy in removing cerebral amyloid buildup,thereby modestly slowing cognitive decline in AD patients[2,3].A 2023 meta-analysis in Neurology demonstrated that anti-amyloid therapies significantly accelerated brain volume loss compared to placebo,with Lecanemab demonstrating 36.4%greater volume reduction and Donanemab 23%.
基金supported by Beijing Natural Science Foundation(5224042).
文摘Aleuropteryx sinica Liu&Yang,2003 is the only species of Aleuropteryx in the family Coniopterygidae found in China.In this study,we used high-throughput sequencing methods to assemble the complete mitochondrial genome of A.sinica.The results showed that the complete mitogenome is 15,600 bp in length and had a high AT content(76.30%),with a typical set of 37 genes,including 13 protein-coding genes(PCGs),22 transfer RNA genes(tRNAs),2 ribosomal RNA genes(rRNAs),and 1 control region(CR)Based on the sequences of 13PCGs+2rRNAs,the phylogenetic analysis revealed that A.sinica,Coniopteryx sp.,Conwentzia sinica Yang,1974,Semidalis macleodi Meinander,1972 and Semidalis aleyrodiformis Stephens,1836 form a clade,which is a sister group to other families of Neuroptera.
基金supported by Key Research and Development Plan of Hunan Province(2024DK2006)the Fundamental Research Funds for the Central Universities of Central South University(1053320221769)+2 种基金Hunan Provincial Respiratory Disease Rehabilitation and Nursing Engineering Research Center Innovation Capacity Building Project(No.202012)the Zhangjiajie Science and Technology Development Key Special Project(No.202304)the National Key Clinical Specialty Major Scientific Research Project(No.20230382).
文摘Background:Glioblastoma(GBM)prognosis has seen little improvement over the past two decades.While immunotherapy has revolutionized cancer treatment,its impact on GBM remains limited.To characterize the evolving research landscape and identify future directions in GBM immunotherapy,we conducted a comprehensive bibliometric review.Methods:All literature related to immunotherapy in GBM from 1999 to 2024 was collected from the Web of Science Core Collection.CtieSpace and VOSviewer were used to conduct bibliometric analysis and visualize the data.Results:Bibliometric analysis identified 5038 publications authored by 23,335 researchers from 4699 institutions across 96 countries/regions,published in 945 journals.The United States produced the highest number of publications,while Switzerland achieved the highest average citation rate.Duke University led in institutional output and citations.John H Sampson was the most productive author,and Roger Stupp was the most cited.Frontiers in Immunology published the most papers,while Clinical Cancer Research was the most cited journal.Research focus centered on adoptive T cell therapy,particularly chimeric antigen receptor(CAR)-T cells with 572 dedicated publications.Within CAR-T research for GBM,the University of Pennsylvania was the leading institution,Frontiers in Immunology the predominant journal,and Christine E Brown(City of Hope National Medical Center)was the most prolific and cited author.Conclusions:There has been a growing interest in GBM immunotherapy over past decades.The United States is the dominant contributor.CAR-T therapy represents the primary research focus.Emerging strategies like chimeric antigen receptor-modified natural killer(CAR-NK)cells,chimeric antigen receptor-engineered macrophages(CAR-M),and cytomegalovirus-specific T cell receptor(CMV-TCR)T cells are gaining prominence,aiming to address limitations in antigen recognition inherent to CAR-T therapy for GBM.
基金supported by the National Natural Science Foundation of China(No.52304329)the Yunnan Fundamental Research Projects(No.202201BE070001-003),Guo Lin would like to acknowledge Xing Dian talent support program of Yunnan Province.
文摘The recovery of precious metals(PMs)from secondary resources is critical for addressing global supply-chain vulnerabilities and sustainable resource utilization.This review systematically examines the transformative potential of metal-organic frameworks(MOFs)as next-generation adsorbents for PM recovery,focusing on their synthesis,functionalization,and multiscale adsorption mechanisms.We critically analyze conventional pyrometallurgical and hydrometallurgical methods and highlight their limitations in terms of selectivity,energy consumption,and secondary pollution.In contrast,MOFs offer tunable porosity,abundant active sites,and tunable surface chemistry,enabling efficient PM capture via synergistic physical and chemical adsorption.Advanced modification techniques,including direct synthesis and post-synthetic modification,are reviewed to propose strategies for enhancing the adsorption kinetics and selectivity for Au,Ag,Pt,and Pd.Key structure-property relationships are established through multiscale characterization and thermodynamic models,revealing the critical roles of hierarchical porosity,soft donor atoms,and framework stability.Industrial challenges,such as aqueous stability and scalability,are addressed via Zr-O bond strengthening,hydrophobic functionalization,and support immobilization.This study consolidates the experimental and theoretical advances in MOF-based PM recovery and provides a roadmap for translating laboratory innovations into practical applications within the circular-economy framework.
基金funded by the National Natural Science Foundation of China (No. 82271572)The Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University (No. XJTU1AF2021CRF-008) and (No. XTJU1AF-CRF2023-025)。
文摘To enhance the anesthetic efficacy of propofol while mitigating its systemic toxicity and irreversible developmental neurotoxicity, we developed a strategy leveraging the neuroprotective effects of baicalin in combination with propofol anesthesia via baicalinbased nanocomposites. High propofol-loaded porous Baicalin-Fe(Ⅲ) infinite coordination polymer@propofol nanocomposites were synthesized, wherein baicalin coordinates with Fe3+ ions to form porous nanoparticles that encapsulate propofol within a core-shell structure. These nanocomposites exhibited an average diameter of 92.3 ± 10.2 nm and a pore volume of 0.322 cm^(3)/g, achieving ultra-high propofol loading(~62%) with no detectable leakage over 100 d, attributed to their large surface area and strong molecular interactions.When combined with focused ultrasound(FUS) and microbubbles, the effective dose(ED_(50))of propofol decreased from 10 to 4.3 mg/kg, doubling the duration of anesthesia and extending the therapeutic window by 200%. Importantly, the therapeutic index improved1.66-fold while vital physiological parameters remained stable. Histological analyses revealed an 80% reduction in neuronal injury compared to free propofol, and behavioral tests demonstrated significant enhancements in motor and cognitive performance, alongside recovery from propofol-induced irreversible developmental neurotoxicity, indicating effective neuroprotection. Collectively, this baicalin-propofol nanocomposite, coupled with FUS-mediated delivery, represents a promising approach for safe and long-term anesthesia in clinical applications.
基金National Natural Science Foundation of China(Grant No.52525504)Emerging Frontiers Cultivation Program of Tianjin University Interdisciplinary Center.
文摘Tactile feedback is critical for human interaction with external information.Similarly,tactile feedback can enrich the user's sensations when using prosthesis.To explore a potential scheme for tactile feedback,this study applied a non-inva-sive Transcutaneous Electrical Nerve Stimulation(TENS)to elicit tactile sensations in the hand,which involved median nerve,ulnar nerve,and radial nerve.Ten able-bodied subjects(8 males,2 females)were recruited to participate in the study.An array of 4×2 electrodes was positioned on the medial aspect of the brachii muscle's short head in the upper arm,which is in proximity to the median nerve,ulnar nerve,and radial nerve.Different electrode pairs were randomly selected to elicit distinct sensations at various positions on the hand,and the subjects reported the sensory areas.Then,the sensory areas and sensory thresholds were confirmed through psychophysical methods.According to the experimental results,tactile sensations were elicited at different locations on the subjects'hand through TENS of different electrode pairs.All subjects reported extensive and detailed sensory areas in the fingers,palm,and dorsum,corresponding to the sensory innervation areas of different nerves.The study effectively demonstrated the ability of TENS in evoking tactile feedback in the hand,paving the way for future optimization and development of prosthetic hands.
基金the National Natural Science Foundation of China(Nos.22150410339,W2432012,22301233 and 22171218)the Ministry of Science and Technology China(No.wgxz2022188)。
文摘α-Chiral amides are common in pharmaceuticals,agrochemicals,natural products,and peptides,prompting the need for new synthetic methods.Here,we introduce a nickel-catalyzed asymmetric reductive amidation method to synthesizeα-chiral amides from benzyl ammonium salts and isocyanates.The key to success is using a chiral 2,2-bipyridine ligand(-)-Ph-SBpy,enabling high yield(up to 95%)and enantiomeric ratio(up to 98:2 er)under mild conditions.Addition of phenol prevents isocyanate polymerization by reversibly forming a carbamate intermediate,enhancing selectivity and efficiency.The synthetic utility is showcased through transformations of the enantioenriched amides,and the mechanism and enantioselectivity are supported by experimental and computational studies.
基金sponsored by the National Natural Science Foundation of China(Grant No.42275171)the Basic Research Operating Expenses of the Institute of Meteorological Sciences,CMA(Grant No.2023Z019)+3 种基金the National Key Research and Development Program of China(Grant No.2022YFF0801304)the China Meteorological Administration Youth Innovation Team Fund(Grant No.CMA2024QN05)a Liaoning Provincial Meteorological Bureau Project(Grant No.D202201)Shenyang Institute of Atmospheric Environment Projects(Grant Nos.2022SYIAEJY13 and 2018SYIAEZD5).
文摘The Northeast China Cold Vortex(NCCV)is a common cut-off low-pressure system in Northeast China,frequently causing localized heavy rainfall,strong winds,and thunderstorms during the early summer.In this study,the clear-sky radiance of 48 longwave channels from the FY-4B Geostationary Interferometric Infrared Sounder(GIIRS)is assimilated into the China Meteorological Administration mesoscale model(CMA-MESO)to evaluate its impact on NCCV development and its effects on rainfall forecasting.The results show that after assimilating the GIIRS radiance data,the warm center at 200 hPa and the cold center at 850 hPa of the NCCV are strengthened,and the dry intrusion at 850 hPa becomes more pronounced.This leads to a stronger NCCV intensity in the following 24 hours and brings the precipitation intensity and area closer to the observation,resulting in significant improvements compared to the experiments that do not assimilate GIIRS radiance data.Furthermore,it is found that the enhancement of the precipitation forecast is associated with the strengthening of cold air in the middle and lower troposphere,which intensifies the uplift of the warm,moist airflow.These results highlight the potential value of GIIRS data assimilation in enhancing early warnings and forecasts of extreme weather events influenced by the NCCV.
基金supported by the National Key Research and Development Program of China(Grant No.2024YFB4610700)the Fundamental Research Funds for the Central Universities(Grant No.JZ2025HGTG0269)+4 种基金the National Natural Science Foundation of China(Grant Nos.52005475,62305321)the Natural Science Foundation of Anhui Province(Grant Nos.JZ2024AKZR0561,2308085QE167)Major Scientific and Technological Projects in Anhui Province(Grant No.202203a05020014)Opening Project of the Key Laboratory of Bionic Engineering(Ministry of Education)Jilin University(Grant No.K202204)。
文摘Smart windows that can repel diverse liquids are highly attractive for the development of self-cleaning building system.Despite immense achievements having been made in drophobic smart windows,unfortunately,the limitations of inferior transparency,unsatisfactory flexibility,and scarce functionality greatly hinder their practical applications.Here,a multifunctional,all-flexible and slef-cleaning electrothermal-actuated(SETA)module with superior transparency is developed by sandwiching the hydrophobic SiO_(2) nanoparticles decorated silver nanowires thin-film heater and the thermo-responsive hydrogel.Through loading/discharging an electric stimulus of 5 V,the optical visibility of SETA could be in situ switched between an opaque state(T_(550)=11.0%)and a transparent state(T_(550)=84.9%)relying on the dynamically collapsed and swollen transition of hydrogel on planar and three-dimensional curved surfaces.Moreover,SETA chipset is able to repel diverse liquids,including organic and inorganic species,showcasing an excellent self-cleaning capability.Lastly,all-in-one multifunctionalities,including pixelated display,thermal regulation,defogging,and self-cleaning on a single SETA chipset,are successfully deployed.Compared to the previous windows,the current SETA chipset is more competent for optical switching in reality,owing to its portable,energy-efficient,flexible,highly-transparent,and on-demand manipulating advantages.This work provides inspirations for self-cleaning greenhouse,tunable optics,intelligent vehicles,and so on.
基金Supported by the Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University,No.CX2023021.
文摘Acute pancreatitis(AP)is sudden inflammation of the pancreas,which can lead to multiple organ dysfunction in severe cases.Hypertriglyceridemia(HTG)is the third most common cause.In recent years,HTG-induced AP(HTG-AP)has garnered increasing attention.Compared to AP caused by other causes,HTG-AP often has a more subtle onset but is more likely to progress to a severe,critical illness that poses a serious threat to a patient’s life and health.Research suggests a potential connection between the gut microbiota and AP,which could be mediated by bacterial metabolites,immune cells,and inflammatory factors.This is supported by observations of microbial imbalance and higher intestinal permeability in patients with AP.In addition,studies have shown that HTG-induced changes in gut microbiota can worsen AP by negatively impacting the host metabolism,immune response,and function of the intestinal barrier.In this review,we summarize recent clinical and animal studies on the role and mechanism of gut microbiota in the severity of AP aggravated by HTG.The application prospects of the newly proposed microbial-host-isozyme concept are summarized,focusing on its potential for the precision diagnosis and treatment of HTG-AP through gut microbiota regulation.
基金supported by the Major Special Projects of the National Natural Science Foundation of China(Grants No.52374170 and 42377465)the Third Comprehensive Scientific Exploration in Xinjiang(Grant No.2022xjkk1005)+1 种基金the Special Technology Innovation Fund of Carbon Peak and Carbon Neutrality in Jiangsu Province(Grant No.BK20231515)the Shaanxi Shenmu Natural Field Observation and Research Station of Erosion and Environment,which provided the site and data on experimental conditions for field trials.
文摘Amid accelerating global land degradation,establishing high-efficiency ecological restoration principles and frameworks is crucial.Here,we explore the application of threshold effects in the ecological restoration process based on field experiments and globally available experimental data from 173 sites.Combining data integration analysis and meta-analysis,we collectively verified the universality of threshold effects in grasslands.The global grasslands’average nitrogen application threshold is 3.78 g·m^(-2)·yr^(−1),while the threshold value of degraded grassland(3.65 g·m^(-2)·yr^(−1))is lower than that of nondegraded grassland(5.90 g·m^(-2)·yr^(−1)).The low nitrogen-driven thresholds are affected by degradation status,climate(precipitation and temperature),and other site conditions,but not fertilization forms.Independent experiments further demonstrated that an increase in soil moisture content can lead to the disappearance of nitrogen threshold effects,revealing that ecological threshold effects are influenced by ecosystem stress factors.Following the significant increase in plant biomass triggered by the nitrogen threshold,the ecosystem undergoes systemic improvement.Soil organic carbon,urease activity,soil microbial diversity,and other soil properties are significantly enhanced.Soil nitrogen cycle-related microbial communities and soil physicochemical attributes are significantly activated.The results indicate that a threshold response pattern may develop before nitrogen saturation is reached,and low nitrogen input can boost productivity and improve the plant-soil-microbe system.Our findings reveal a nonprogressive path of restoration in degraded ecosystems,and thus,restoration based on threshold effects can offer an efficient and safe solution to combat ecological degradation.
基金the National Key Project for Basic Research of China(973 Project)(No.2005CB221402)the China National Petroleum Corporation.
文摘The surface species of CO hydrogenation on CeO2-Co/SiO2 catalyst were investigated using the techniques of temperature programmed reaction and transient response method. The results indicated that the formation of H2O and CO2 was the competitive reaction for the surface oxygen species, CH4 was produced via the hydrogenation of carbon species step by step, and C2 products were formed by the polymerization of surface-active carbon species （-CH2-）. Hydrogen assisted the dissociation of CO. The hydrogenation of surface carbon species was the rate-limiting step in the hydrogenation of CO over CeO2-Co/SiO2 catalyst. The investigation of total pressure, gas hourly space velocity （GHSV）, and product distribution using nitrogen-rich synthesis gas as feedstock over a laboratory scale fixed-bed reactor indicated that total pressure and GHSV had a significant effect on the catalytic performance of CeO2-Co/SiO2 catalyst. The removal of heat and control of the reaction temperature were extremely critical steps, which required lower GHSV and appropriate CO conversion to avoid the deactivation of the catalyst. The feedstock of nitrogen-rich synthesis gas was favorable to increase the conversion of CO, but there was a shift of product distribution toward the light hydrocarbon. The nitrogen-rich synthesis gas was feasible for F-T synthesis for the utilization of remote natural gas.
基金supported by the U.S. National Institutes of Health grants (U24 CA143835 to IS and WZ, P50 CA083639 and P50 CA098258 to AKS)MD Anderson support grant (CA016672) to WZ+6 种基金a grant from the Blanton-Davis Ovarian Cancer Research Program to WZgrants from the Program for Changjiang Scholars, Innovative Research Team in University (PCSIRT) in Chinathe National Key Scientifi c and Technological Project (2011ZX0 9307-001-04)Tianjin Science and Technology Committee Foundation (09ZCZDSF04700) to KCa grant from National Nature Science Foundation of China (#81201651) to YSa grant from Fondazione CARIPLO (2013-0865) to DMthe A. Lavoy Moore Endowment Fund to YS and DY
文摘Metastasis is the main cause of cancer mortality. One of the initiating events of cancer metastasis of epithelial tumors is epithelial-to-mesenchymal transition(EMT), during which cells dedifferentiate from a relatively rigid cell structure/morphology to a flexible and changeable structure/morphology often associated with mesenchymal cells. The presence of EMT in human epithelial tumors is reflected by the increased expression of genes and levels of proteins that are preferentially present in mesenchymal cells. The combined presence of these genes forms the basis of mesenchymal gene signatures, which are the foundation for classifying a mesenchymal subtype of tumors. Indeed, tumor classification schemes that use clustering analysis of large genomic characterizations, like The Cancer Genome Atlas(TCGA), have defined mesenchymal subtype in a number of cancer types, such as high-grade serous ovarian cancer and glioblastoma. However, recent analyses have shown that gene expression-based classifications of mesenchymal subtypes often do not associate with poor survival. This "paradox" can be ameliorated using integrated analysis that combines multiple data types. We recently found that integrating m RNA and micro RNA(mi RNA) data revealed an integrated mesenchymal subtype that is consistently associated with poor survival in multiple cohorts of patients with serous ovarian cancer. This network consists of 8 major mi RNAs and 214 m RNAs. Among the 8 mi RNAs, 4 are known to be regulators of EMT. This review provides a summary of these 8 mi RNAs, which were associated with the integrated mesenchymal subtype of serous ovarian cancer.
基金supported in part by the National Natural Science Foundation of China(61903090,61727810,62073086,62076077,61803096,U191140003)the Guangzhou Science and Technology Program Project(202002030289)Japan Society for the Promotion of Science(JSPS)KAKENHI(18K18083)。
文摘Key frame extraction based on sparse coding can reduce the redundancy of continuous frames and concisely express the entire video.However,how to develop a key frame extraction algorithm that can automatically extract a few frames with a low reconstruction error remains a challenge.In this paper,we propose a novel model of structured sparse-codingbased key frame extraction,wherein a nonconvex group log-regularizer is used with strong sparsity and a low reconstruction error.To automatically extract key frames,a decomposition scheme is designed to separate the sparse coefficient matrix by rows.The rows enforced by the nonconvex group log-regularizer become zero or nonzero,leading to the learning of the structured sparse coefficient matrix.To solve the nonconvex problems due to the log-regularizer,the difference of convex algorithm(DCA)is employed to decompose the log-regularizer into the difference of two convex functions related to the l1 norm,which can be directly obtained through the proximal operator.Therefore,an efficient structured sparse coding algorithm with the group log-regularizer for key frame extraction is developed,which can automatically extract a few frames directly from the video to represent the entire video with a low reconstruction error.Experimental results demonstrate that the proposed algorithm can extract more accurate key frames from most Sum Me videos compared to the stateof-the-art methods.Furthermore,the proposed algorithm can obtain a higher compression with a nearly 18% increase compared to sparse modeling representation selection(SMRS)and an 8% increase compared to SC-det on the VSUMM dataset.
基金supported by the National Natural Science Foundation of China(32270476)。
文摘This study reported two new species:Newsteadia multipori Zheng&Wu,sp.nov.,collected from pine needle litter in Guizhou Province,are described and illustrated for its adult female,male,and first-,second-and third-instar nymphs;N.chebalingensis Zheng&Wu,sp.nov.,collected from broad leaf litter in Guangdong Province,are described and illustrated for its adult female and first-instar nymph.Identification keys are provided to the adult females of Newsteadia species known in China and to the adult males of Newsteadia species known worldwide.
基金supported in part by a grant from the National Natural Science Foundation of China,No. 81071150,10872156the National High Technology Research and Development Program of China (863 Program),No.2006AA04Z370
文摘Rhesus monkey models of Parkinson＇s disease were induced by injection of N-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine. Neural firings were recorded using microelectrodes placed in the interna segment of the globus pallidus. The wavelets and power spectra show gradual power reduction during the disease process along with increased firing rates in the Parkinson＇s disease state. Singular values of coefficients decreased considerably during tremor-related activity as well as in the Parkinson＇s disease state compared with normal signals, revealing that higher-frequency components weaken when Parkinson＇s disease occurs. We speculate that the death of neurons could be reflected by irregular frequency spike trains, and that wavelet packet decomposition can effectively detect the degradation of neurons and the loss of information transmission in the neural circuitry.
