The development of pattern-based traditional Chinese medicine(TCM)compound preparations constitutes a core domain that represents the principle of pattern differentiation-based treatment,a hallmark of TCM.However,the ...The development of pattern-based traditional Chinese medicine(TCM)compound preparations constitutes a core domain that represents the principle of pattern differentiation-based treatment,a hallmark of TCM.However,the field has long been constrained by scientific and regulatory challenges in animal modeling,efficacy evaluation,and clinical positioning.This article proposes a new research and development(R&D)paradigm strategically based on human use experience(HUE)and centered on the patient as the key to overcoming these bottlenecks and achieving high-quality progress.We systematically dissect the traditional problems in this field and demonstrate the pivotal role of high-quality HUE in enabling precise clinical positioning and optimizing R&D pathways(e.g.,applying for exemptions from non-clinical studies).HUE guides the implementation of the“pattern-symptom integration”model.Furthermore,we detail the implementation of the patient-centered concept throughout the process of clinical trial design,collection of patients’experience data,clinical outcome assessment,and benefit-risk assessment.The integrative application of artificial intelligence in the R&D of pattern-based TCM drugs is also specifically explored.By synthesizing the“TCM theory,HUE,and clinical trials”evidence system,this article aims to provide a systematic strategic framework for establishing an R&D pathway that adheres to the intrinsic principles of TCM while simultaneously meeting modern scientific standards.展开更多
The development of blockchain is at a nascent stage.Current research on blockchain mainly focuses on a single technology,failing to reflect the correlation between the integrated technologies due to a lack of applicat...The development of blockchain is at a nascent stage.Current research on blockchain mainly focuses on a single technology,failing to reflect the correlation between the integrated technologies due to a lack of application in the real world.In this paper,according to the function classification,we divide blockchain technology into five layers:the data layer,the network layer,the consensus layer,the contract layer,and the application layer.For each layer,we elaborate on its technical principles and the latest research status.We also provide empirical cases of blockchain application.This paper summarizes the general functional modules of the blockchain to support the rapid implementation of blockchain applications.In the end,we investigate the challenges faced by blockchain technology and present the research prospects.展开更多
This article provides an overview of the application of bionic technology in marine cruising equipment,discussing its research progress and future development trends.Marine cruising is a crucial means of gaining insig...This article provides an overview of the application of bionic technology in marine cruising equipment,discussing its research progress and future development trends.Marine cruising is a crucial means of gaining insights into the marine environment and conducting scientific research.However,conventional marine cruising equipment faces numerous challenges when dealing with complex and ever-changing marine environments.Bionic technology,as a means of drawing inspiration from the structure and functions of living organisms,offers new approaches and methods to address the challenges faced by marine cruising equipment and has found widespread application.The article primarily focuses on the applications and historical developments of bionic technology in propulsion methods,drag reduction,and surface antifouling.It summarizes the design principles,manufacturing techniques,and optimization methods for marine biomimetic cruising equipment.Finally,this paper analyzes the achievements,challenges,and future directions of bionic technology in marine cruising equipment.The application of bionic technology in marine cruising equipment holds vast potential for development,enabling us to better confront the challenges of marine exploration and research by drawing wisdom from nature and driving advancements in marine science.展开更多
This paper discusses about the purity of strengthened pure platinum wire and the development method of platinum micro wire, in order to solve the difficulties of low tensile strength, easy to break, and low rate of mi...This paper discusses about the purity of strengthened pure platinum wire and the development method of platinum micro wire, in order to solve the difficulties of low tensile strength, easy to break, and low rate of micro wire. And it contrasts some performance of strengthened pure platinum wire and sponge Pt wire. The researches draw a conclusion that the thermoelectric properties of strengthened pure platinum micro wire was in accordance with national standards and satisfied users' requirements.展开更多
In the sixth generation mobile communication(6G) system,Non-Terrestrial Networks(NTN),as a supplement to terrestrial network,can meet the requirements of wide area intelligent connection and global ubiquitous seamless...In the sixth generation mobile communication(6G) system,Non-Terrestrial Networks(NTN),as a supplement to terrestrial network,can meet the requirements of wide area intelligent connection and global ubiquitous seamless access,establish intelligent connection for wide area objects,and provide intelligent services.Due to issues such as massive access,doppler shift,and limited spectrum resources in NTN,research on resource management is crucial for optimizing NTN performance.In this paper,a comprehensive survey of multi-pattern heterogeneous NTN resource management is provided.Firstly,the key technologies involved in NTN resource management is summarized.Secondly,NTN resource management is discussed from network pattern and resource pattern.The network pattern focuses on the application of different optimization methods to different network dimension communication resource management,and the resource type pattern focuses on the research and application of multi-domain resource management such as computation,cache,communication and sensing.Finally,future research directions and challenges of 6G NTN resource management are discussed.展开更多
The technology of solid-state lighting has developed for decades in various industries.Phosphor,as an element part,determines the application domain of lighting products.For instance,blue and redemitting phosphors are...The technology of solid-state lighting has developed for decades in various industries.Phosphor,as an element part,determines the application domain of lighting products.For instance,blue and redemitting phosphors are required in the process of plant supplementing light,arrow-band emitting phosphors are applied to backlight displays,etc.In this work,a Bi^(3+)-activated blue phosphor was obtained in a symmetrical and co mpact crystal structure of Gd3Sb07(GSO).Then,the co-doping strategy of alkali metal ions(Li^(+),Na^(+),and K^(+))was used to optimize the performance.The result shows that the photoluminescence intensity is increased by 2.1 times and 1.3 times respectively by introducing Li~+and K^(+)ions.Not only that,it also achieves narrow-band emitting with the full width of half-maximum(FWHM)reaching 42 nm through Na^(+)doping,and its excitation peak position also shifts from 322 to 375 nm,which can be well excited by near-ultraviolet(NUV)light emitting diode(LED)chips(365 nm).Meanwhile,the electroluminescence spectrum of GSO:0.6 mol%Bi^(3+),3 wt%Na^(+)matches up to 93.39%of the blue part of the absorption spectrum of chlorophyll a.In summary,the Bi^(3+)-activated blue phosphor reported in this work can synchronously meet the requirements of plant light replenishment and field emission displays.展开更多
In the era of digital intelligence,data is a key element in promoting social and economic development.Educational data,as a vital component of data,not only supports teaching and learning but also contains much sensit...In the era of digital intelligence,data is a key element in promoting social and economic development.Educational data,as a vital component of data,not only supports teaching and learning but also contains much sensitive information.How to effectively categorize and protect sensitive data has become an urgent issue in educational data security.This paper systematically researches and constructs a multi-dimensional classification framework for sensitive educational data,and discusses its security protection strategy from the aspects of identification and desensitization,aiming to provide new ideas for the security management of sensitive educational data and to help the construction of an educational data security ecosystem in the era of digital intelligence.展开更多
In multi-component oil and gas exploration using ocean bottom nodes,converted wave data is rich in lithological and fracture information.One of the urgent problems to be solved is how to construct an accurate shear wa...In multi-component oil and gas exploration using ocean bottom nodes,converted wave data is rich in lithological and fracture information.One of the urgent problems to be solved is how to construct an accurate shear wave velocity model of the shallow sea bottom by leveraging the seismic wave information at the fluid-solid interface in the ocean,and improve the lateral resolution of marine converted wave data.Given that the dispersion characteristics of surface waves are sensitive to the S-wave velocity of subsurface media,and that Scholte surface waves,which propagate at the interface between liquid and solid media,exist in the data of marine oil and gas exploration,this paper proposes a Scholte wave inversion and modeling method based on oil and gas exploration using ocean bottom nodes.By using the method for calculating the Scholte wave dispersion spectrum based on the Bessel kernel function,the accuracy of dispersion spectrum analysis is improved,and more accurate dispersion curves are picked up.Through the adaptive weighted least squares Scholte wave dispersion inversion algorithm,the Scholte wave dispersion equation for liquid-solid media is solved,and the shear wave velocity model of the shallow sea bottom is calculated.Theoretical tests and applications of realdata have proven that this method can significantly improve the lateral resolution of converted wave data,provide high-quality data for subsequent inversion of marine multi-component oil and gas exploration data and reservoir reflection information,and contribute to the development of marine oil and gas exploration technology.展开更多
The tensile strength of rocks under real-time high-temperatures is essential for enhanced geothermal system development.However,the complex occurrence and deep burial of hot dry rocks limit the quantity and quality of...The tensile strength of rocks under real-time high-temperatures is essential for enhanced geothermal system development.However,the complex occurrence and deep burial of hot dry rocks limit the quantity and quality of standard samples for mechanical testing.This paper compared the tensile strengths obtained from Brazilian splitting tests on standard samples(with a diameter of 50 mm and a thickness of 25 mm)and micro-tensile samples(with a diameter of 50 mm and a thickness of 25 mm)of two types of granites.A power-law size effect model was established between the two sets of data,validating the reliability of the testing method.Then,miniature Brazilian splitting under real-time high-temperature,combined with X-ray diffraction(XRD)revealed temperature-dependent strength variations and microstructural damage mechanisms.The results show that:(1)The comparison error between the tensile strength obtained by the fitting model and that of the measured standard samples was less than 6%.(2)In real-time high-temperature conditions,tensile strength of granite exhibited non-monotonic behavior,increasing below 300°C before decreasing,with sharp declines at 400–500°C and 600–700°C.(3)Thermal damage stems from the differences in the high-temperature behavior of minerals,including dehydration,phase transformation,and differential expansion.展开更多
This article summarizes recent domestic literature on the use of Huangqin(Scutellaria baicalensis)in the treatment of lung cancer.It reviews the mechanism of action of Huangqin in treating lung cancer from six aspects...This article summarizes recent domestic literature on the use of Huangqin(Scutellaria baicalensis)in the treatment of lung cancer.It reviews the mechanism of action of Huangqin in treating lung cancer from six aspects:inhibiting the growth of lung cancer cells,inducing apoptosis of lung cancer cells,inducing autophagy of lung cancer cells,inhibiting the migration of lung cancer cells,promoting the differentiation of lung cancer cells,and improving immune function.The aim is to provide a reference for the material basis and further research on the anti-inflammatory and anti-tumor efficacy of Huangqin.展开更多
Brown carbon(BrC)has attracted widespread attention because of its strong absorption of solar radiation in the ultraviolet-visible wavelength range,which causes adverse impacts on human health.Originally,BrC was a phy...Brown carbon(BrC)has attracted widespread attention because of its strong absorption of solar radiation in the ultraviolet-visible wavelength range,which causes adverse impacts on human health.Originally,BrC was a physically defined class of substances.However,current research has gradually shifted towards the identification of its chemical groups,because its light-absorbing capability,chemical properties and health effects mainly depend on the chemical composition of its chromophores.Therefore,this review mainly focuses on the chemical understanding of BrC based on chromophores,and the secondary formation mechanism of chromophores,photosensitized reactions,and human health effects of BrC were detailly summarized.Firstly,BrC chromophores are divided into five categories:nitrogen-heterocycles,nitrogen-chain,aromatic species,oligomers and sulfur-containing organic compounds.Different chromophore precursor species exhibit variations,and their formation mechanisms are also distinct.Secondly,BrC can trigger the production of secondary organic aerosol(SOA)precursors or cause SOA growth because BrC is an important component of light-absorbing particles formed during incomplete combustion of biomass and fossil fuels,potentially exerting adverse effects on human health.Finally,developing sufficiently separated methods for BrC and refining algorithms and machine learning can lead to a more effective understanding of the chemical composition of chromophores,thus enabling better evaluation of the atmospheric effects and health impacts of BrC.In all,this review provides new insights into the categories of BrC chromophores and new advance in secondary formation mechanisms,photosensitized reactions,and human health effects on the basis of chemical structures.展开更多
Aluminum industrial solid waste represents a highly abundant yet underutilized resource.Its incorporation into asphalt pavement applications can effectively reduce the exploitation of natural resources and mitigate en...Aluminum industrial solid waste represents a highly abundant yet underutilized resource.Its incorporation into asphalt pavement applications can effectively reduce the exploitation of natural resources and mitigate environmental issues caused by waste accumulation.This paper focuses on typical solid waste resources generated by the aluminum industry,summarizing the latest research progress in their application within the asphalt pavement industry and proposing key directions for future attention.The physicochemical properties of red mud(RM),spent aluminum electrolytic cathode materials,and secondary aluminum dross(SAD)are reviewed.The effects and mechanisms of RM,spent aluminum electrolytic cathode materials,and SAD on the performance of asphalt and its mixtures are elaborated.RM significantly enhances the aging resistance of asphalt,the hightemperature rheological properties of asphalt mastic,and the rutting resistance of asphalt mixtures.Spent aluminum electrolytic cathode materials require the removal of fluorides and cyanides before further application in asphalt pavement.SAD effectively improves the dynamic stability of asphalt mixtures.This review presents the first systematic summary of key scientific challenges and technical bottlenecks in the application of aluminum industrial solid waste in asphalt pavements.It clarifies that future research should prioritize waste pretreatment technologies,performance regulation mechanisms,and life cycle environmental impact assessments.These contributions provide essential theoretical foundations and technical guidance for advancing the resource utilization of aluminum industrial solid waste,holding substantial significance for promoting the development of green transportation infrastructure.展开更多
This study innovatively employs functional near-infrared spectroscopy(fNIRS)technology to investigate passengers’brain responses to various external stimuli during high-speed train operations,assessing their impact o...This study innovatively employs functional near-infrared spectroscopy(fNIRS)technology to investigate passengers’brain responses to various external stimuli during high-speed train operations,assessing their impact on passenger comfort.Three stimuli are examined:passing through tunnels,sonic booms at tunnel exits,and two trains meeting within the tunnel.The analysis of environmental variables,including cabin noise,cabin-to-external pressure,and cabin-to-body acceleration,reveals that changes in auditory and pressure levels during the tunnel experience led to an 87%increase in oxygenated hemoglobin(HbO)levels in the temporal lobe(TL).This reflects a brief discomfort that subsides as passengers adapt,with HbO levels nearly returning to pre-tunnel levels upon exit.Among the stimuli,the sonic boom triggered the most significant neural response,with HbO fluctuations increased by 175%.In contrast,the impact of train meetings was minor,yielding an average HbO increase of only 14.21%.Connectivity analysis further shows significant enhancements in brain functional connectivity during tunnel entrance and sonic boom scenarios,with increases of 52%and 80%,respectively.Our findings contribute to passenger comfort assessment by establishing objective neurophysiological measures that quantify previously subjective experiences.The application of fNIRS in this dynamic environment creates new possibilities for evidence-based comfort optimization in railway design.展开更多
Osteoarthritis(OA)is a kind of joint diseases characterized by fibrosis,ulceration,and loss of articular cartilage and articular surrounding tissues caused by various factors,the main symptoms of OA include joint pain...Osteoarthritis(OA)is a kind of joint diseases characterized by fibrosis,ulceration,and loss of articular cartilage and articular surrounding tissues caused by various factors,the main symptoms of OA include joint pain,joint stiffness,and loss of joint function,and OA has the higher prevalence rate and has been listed as one of the four major disabling diseases,seriously affecting people’s lives and health.Traditional Chinese medicine(TCM)is a comprehensive science based on the theory of Yin Yang(one TCM theory,the material world is believed to be nurtured,developed,and changed under the influence of Yin and Yang)and Five Elements(The five most basic substances-wood,fire,earth,metal,and water-are considered indispensable elements that make up the world),based on TCM theory and practical experience it can play the important role in prevention,diagnosis,treatment,rehabilitation,and health care in OA,exhibit the great application potential for OA treatment.In this review,we have summarized the recent research progress in the application of TCM in OA,including an analysis of underlying mechanisms,application limitations,and potential solutions,found that the material basis and targets of the therapeutic component of TCM,the quality control and the mechanism of TCM application in OA are not very clear,which may become the application limitation of TCM in OA.We hope that this review will offer valuable insights to researchers in the field.展开更多
Atmospheric turbulence is an important parameter affecting laser atmospheric transmission.This paper reports on a self-developed atmospheric turbulence detection Li DAR system(scanning differential image motion Li DAR...Atmospheric turbulence is an important parameter affecting laser atmospheric transmission.This paper reports on a self-developed atmospheric turbulence detection Li DAR system(scanning differential image motion Li DAR(DIM-Li DAR)system).By designing and simulating the optical system of atmospheric turbulence detection Li DAR,the basic optical imaging accuracy has been determined.展开更多
Over the past several decades,the integration of IONs into EP emerged as an effective method for enhancing its mechanical properties.Nevertheless,challenges remain,especially with u-IONs,where the interfacial strength...Over the past several decades,the integration of IONs into EP emerged as an effective method for enhancing its mechanical properties.Nevertheless,challenges remain,especially with u-IONs,where the interfacial strength with EP is suboptimal,resulting in aggregation within the EP matrix and a subsequent deterioration in the mechanical performance of u-ION/EP nanocomposites.In this comprehensive review,we explored advanced chemical modification techniques tailored for IONs incorporated into EP,providing a detailed examination of the mechanical characteristics of surface cm-ION/EP nanocomposites.This review investigates various chemical modification methods and their distinct impacts on the mechanical attributes of the resulting EP nanocomposites.Special emphasis is given to addressing the persistent challenges of inadequate interfacial strength and aggregation.Furthermore,this article examines prospective surface modification approaches for inorganic oxide nanoparticles,offering a visionary outlook on methods to improve the mechanical performance of EP in future.展开更多
Objective:Hyper-progression recurrence(HPR)after hepatectomy is a specific recurrence pattern associated with extremely poor prognosis in patients with hepatocellular carcinoma(HCC).This study was aimed at investigati...Objective:Hyper-progression recurrence(HPR)after hepatectomy is a specific recurrence pattern associated with extremely poor prognosis in patients with hepatocellular carcinoma(HCC).This study was aimed at investigating the probable risk factors and establishing comprehensive models for formulating clinical strategies.Methods:Overall,16,158 patients with HCC from 8 hospitals were screened,among whom 3,125 patients who underwent R0 resection were included,and divided into development(n=2,113)and validation(n=1,012)cohorts.A comprehensive study of HPR predictive models and biological features was conducted.Results:Among the 3,125 enrolled patients,506(16.19%)developed HPR.The influence of HPR on extremely poor prognosis was reflected by recurrence features,adverse effects on systemic and liver function,and limited therapeutic options.Nine variables closely associated with HPR were identified,and incorporated into nomogram and conditional inference tree models,which successfully achieved pre-and post-operative HPR risk stratification and facilitated clinical decision-making.Multi-dimensional verification also confirmed the predictive accuracy of model combinations and their reliability in clinical applications.Furthermore,biological analyses revealed that HCCs with HPR exhibited hyperactive biological processes,inactive metabolism,and immune exhaustion features,together with high MYCN/HMGA2 co-expression,thereby enhancing understanding of the molecular events leading to HPR and providing valuable knowledge for HPR management.Conclusions:HPR after hepatectomy is associated with extremely poor prognosis and requires substantial attention.We constructed comprehensive predictive models and propose a clinical strategy for guiding HPR prevention and management.展开更多
1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many ...1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging.展开更多
Mytilus contain abundant antimicrobial peptides(AMPs)that play a key role in the innate immunity.However,heterologous production of these AMPs remains challenging due to their short sequences,multiple disulfide bonds,...Mytilus contain abundant antimicrobial peptides(AMPs)that play a key role in the innate immunity.However,heterologous production of these AMPs remains challenging due to their short sequences,multiple disulfide bonds,and high content of cationic amino acids,which hinder functional expression in prokaryotic systems such as Escherichia coli.To establish a eukaryotic recombinant expression system for the AMPs of mussel and obtain recombinant mussel AMPs for subsequent studies,we reported the successful recombinant expression of myticofensin B1,a novel defensin-like AMP identified previously in Mytiluscoruscus,using the eukaryotic host Pichia pastoris.The codon-optimized gene encoding the mature myticofensin-B1(composed of 65 amino acid residues,including 6 conserved cysteine residues)was cloned into a pPICZαA vector and expressed in P.pastoris GS115.Structural fidelity of the recombinant peptide was confirmed by liquid chromatography-tandem mass spectrometry(LC-MS/MS),showing a molecular weight of 8849.9 Da,which was consistent with the theoretical prediction.Functional assays demonstrated a broad-spectrum antimicrobial activity of the recombinant myticofensin-B1,with stronger inhibition against Gram-negative bacteria.Scanning electron microscopy revealed different effects of the recombinant myticofensin-B1 against different bacteria.In addition,the recombinant myticofensin-B1 exhibited a very low hemolytic activity against sheep red blood cells and weak cytotoxicity against human A549 lung cancer cells.This study establishes P.pastoris as a powerful platform to produce functional mussel AMP and highlights the potential of the recombinant myticofensin-B1 as a therapeutic agent for aquaculture pathogens and infections.展开更多
基金supported by the Key Laboratory of Clinical Evaluation Technology for Human Experience with Chinese Medicine,Science and Technology Innovation Project of Guangdong Provincial Medical Products Administration(2022ZDB06)the Jointly Funded Project by Guangzhou Science and Technology Bureau,Research Institutes and Enterprises(2024A03j0355)+1 种基金the State Key Laboratory of Traditional Chinese Medicine Syndrome"Unveiling the List and Taking on Leadership"Project(SKLKY2025C0013)the National Key Research and Development Program of China(2025YFC3507902).
文摘The development of pattern-based traditional Chinese medicine(TCM)compound preparations constitutes a core domain that represents the principle of pattern differentiation-based treatment,a hallmark of TCM.However,the field has long been constrained by scientific and regulatory challenges in animal modeling,efficacy evaluation,and clinical positioning.This article proposes a new research and development(R&D)paradigm strategically based on human use experience(HUE)and centered on the patient as the key to overcoming these bottlenecks and achieving high-quality progress.We systematically dissect the traditional problems in this field and demonstrate the pivotal role of high-quality HUE in enabling precise clinical positioning and optimizing R&D pathways(e.g.,applying for exemptions from non-clinical studies).HUE guides the implementation of the“pattern-symptom integration”model.Furthermore,we detail the implementation of the patient-centered concept throughout the process of clinical trial design,collection of patients’experience data,clinical outcome assessment,and benefit-risk assessment.The integrative application of artificial intelligence in the R&D of pattern-based TCM drugs is also specifically explored.By synthesizing the“TCM theory,HUE,and clinical trials”evidence system,this article aims to provide a systematic strategic framework for establishing an R&D pathway that adheres to the intrinsic principles of TCM while simultaneously meeting modern scientific standards.
基金Supported by the National Natural Science Foundation of China(61762049,61862033,61902162)Natural Science Foundation of Jiangxi Province(20202BABL202025,20202BABL202026,20202BAB202015)。
文摘The development of blockchain is at a nascent stage.Current research on blockchain mainly focuses on a single technology,failing to reflect the correlation between the integrated technologies due to a lack of application in the real world.In this paper,according to the function classification,we divide blockchain technology into five layers:the data layer,the network layer,the consensus layer,the contract layer,and the application layer.For each layer,we elaborate on its technical principles and the latest research status.We also provide empirical cases of blockchain application.This paper summarizes the general functional modules of the blockchain to support the rapid implementation of blockchain applications.In the end,we investigate the challenges faced by blockchain technology and present the research prospects.
基金Supported by the Youth Science and Technology Innovation Program of Xiamen Ocean and Fisheries Development Special Funds(No.23ZHZB034QCB38).
文摘This article provides an overview of the application of bionic technology in marine cruising equipment,discussing its research progress and future development trends.Marine cruising is a crucial means of gaining insights into the marine environment and conducting scientific research.However,conventional marine cruising equipment faces numerous challenges when dealing with complex and ever-changing marine environments.Bionic technology,as a means of drawing inspiration from the structure and functions of living organisms,offers new approaches and methods to address the challenges faced by marine cruising equipment and has found widespread application.The article primarily focuses on the applications and historical developments of bionic technology in propulsion methods,drag reduction,and surface antifouling.It summarizes the design principles,manufacturing techniques,and optimization methods for marine biomimetic cruising equipment.Finally,this paper analyzes the achievements,challenges,and future directions of bionic technology in marine cruising equipment.The application of bionic technology in marine cruising equipment holds vast potential for development,enabling us to better confront the challenges of marine exploration and research by drawing wisdom from nature and driving advancements in marine science.
文摘This paper discusses about the purity of strengthened pure platinum wire and the development method of platinum micro wire, in order to solve the difficulties of low tensile strength, easy to break, and low rate of micro wire. And it contrasts some performance of strengthened pure platinum wire and sponge Pt wire. The researches draw a conclusion that the thermoelectric properties of strengthened pure platinum micro wire was in accordance with national standards and satisfied users' requirements.
基金supported in part by the National Natural Science Foundation of China under Grant 62225103,U22B2003,U2441227,and U24A20211the Beijing Natural Science Foundation under Grant L241008+3 种基金the Defense Industrial Technology Development Program JCKY2022110C010the National Key Laboratory of Wireless Communications Foundation under Grant IFN20230201the Fundamental Research Funds for the Central Universities under Grant FRFTP-22-002C2the Xiaomi Fund of Young Scholar。
文摘In the sixth generation mobile communication(6G) system,Non-Terrestrial Networks(NTN),as a supplement to terrestrial network,can meet the requirements of wide area intelligent connection and global ubiquitous seamless access,establish intelligent connection for wide area objects,and provide intelligent services.Due to issues such as massive access,doppler shift,and limited spectrum resources in NTN,research on resource management is crucial for optimizing NTN performance.In this paper,a comprehensive survey of multi-pattern heterogeneous NTN resource management is provided.Firstly,the key technologies involved in NTN resource management is summarized.Secondly,NTN resource management is discussed from network pattern and resource pattern.The network pattern focuses on the application of different optimization methods to different network dimension communication resource management,and the resource type pattern focuses on the research and application of multi-domain resource management such as computation,cache,communication and sensing.Finally,future research directions and challenges of 6G NTN resource management are discussed.
基金Project supported by the Key R&D Projects in Hunan Province(2021SK2047,2022NK2044)Science and Technology Innovation Program of Hunan Province(2022WZ1022)Superior Youth Project of the Science Research Project of Hunan Provincial Department of Education(22B0211)。
文摘The technology of solid-state lighting has developed for decades in various industries.Phosphor,as an element part,determines the application domain of lighting products.For instance,blue and redemitting phosphors are required in the process of plant supplementing light,arrow-band emitting phosphors are applied to backlight displays,etc.In this work,a Bi^(3+)-activated blue phosphor was obtained in a symmetrical and co mpact crystal structure of Gd3Sb07(GSO).Then,the co-doping strategy of alkali metal ions(Li^(+),Na^(+),and K^(+))was used to optimize the performance.The result shows that the photoluminescence intensity is increased by 2.1 times and 1.3 times respectively by introducing Li~+and K^(+)ions.Not only that,it also achieves narrow-band emitting with the full width of half-maximum(FWHM)reaching 42 nm through Na^(+)doping,and its excitation peak position also shifts from 322 to 375 nm,which can be well excited by near-ultraviolet(NUV)light emitting diode(LED)chips(365 nm).Meanwhile,the electroluminescence spectrum of GSO:0.6 mol%Bi^(3+),3 wt%Na^(+)matches up to 93.39%of the blue part of the absorption spectrum of chlorophyll a.In summary,the Bi^(3+)-activated blue phosphor reported in this work can synchronously meet the requirements of plant light replenishment and field emission displays.
基金supported by China national high-technology industrialized boosting plan(99-257)Emphasesresearch plan of science and technology of Yunnan ProvinceGovernment(97-023)emphases research plan of scienceand technology of Kunming City Government(98-016).
基金Education Science planning project of Jiangsu Province in 2024(Grant No:B-b/2024/01/152)2025 Jiangsu Normal University Graduate Research and Innovation Program school-level project“Research on the Construction and Desensitization Strategies of Education Sensitive Data Classification from the Perspective of Educational Ecology”。
文摘In the era of digital intelligence,data is a key element in promoting social and economic development.Educational data,as a vital component of data,not only supports teaching and learning but also contains much sensitive information.How to effectively categorize and protect sensitive data has become an urgent issue in educational data security.This paper systematically researches and constructs a multi-dimensional classification framework for sensitive educational data,and discusses its security protection strategy from the aspects of identification and desensitization,aiming to provide new ideas for the security management of sensitive educational data and to help the construction of an educational data security ecosystem in the era of digital intelligence.
基金financially supported by the Scientific Research and Technology Development Project of China National Petroleum Corporation(No.2021ZG02)titled"Development of Seismic Data Processing Software for Ocean Nodes(OBN)"。
文摘In multi-component oil and gas exploration using ocean bottom nodes,converted wave data is rich in lithological and fracture information.One of the urgent problems to be solved is how to construct an accurate shear wave velocity model of the shallow sea bottom by leveraging the seismic wave information at the fluid-solid interface in the ocean,and improve the lateral resolution of marine converted wave data.Given that the dispersion characteristics of surface waves are sensitive to the S-wave velocity of subsurface media,and that Scholte surface waves,which propagate at the interface between liquid and solid media,exist in the data of marine oil and gas exploration,this paper proposes a Scholte wave inversion and modeling method based on oil and gas exploration using ocean bottom nodes.By using the method for calculating the Scholte wave dispersion spectrum based on the Bessel kernel function,the accuracy of dispersion spectrum analysis is improved,and more accurate dispersion curves are picked up.Through the adaptive weighted least squares Scholte wave dispersion inversion algorithm,the Scholte wave dispersion equation for liquid-solid media is solved,and the shear wave velocity model of the shallow sea bottom is calculated.Theoretical tests and applications of realdata have proven that this method can significantly improve the lateral resolution of converted wave data,provide high-quality data for subsequent inversion of marine multi-component oil and gas exploration data and reservoir reflection information,and contribute to the development of marine oil and gas exploration technology.
基金supported by the National Natural Science Foundation of China(Nos.52174175 and 52274078)the Program for the Scientific and Technological Innovation Team in Universities of Henan Province(No.23IRTSTHN005)。
文摘The tensile strength of rocks under real-time high-temperatures is essential for enhanced geothermal system development.However,the complex occurrence and deep burial of hot dry rocks limit the quantity and quality of standard samples for mechanical testing.This paper compared the tensile strengths obtained from Brazilian splitting tests on standard samples(with a diameter of 50 mm and a thickness of 25 mm)and micro-tensile samples(with a diameter of 50 mm and a thickness of 25 mm)of two types of granites.A power-law size effect model was established between the two sets of data,validating the reliability of the testing method.Then,miniature Brazilian splitting under real-time high-temperature,combined with X-ray diffraction(XRD)revealed temperature-dependent strength variations and microstructural damage mechanisms.The results show that:(1)The comparison error between the tensile strength obtained by the fitting model and that of the measured standard samples was less than 6%.(2)In real-time high-temperature conditions,tensile strength of granite exhibited non-monotonic behavior,increasing below 300°C before decreasing,with sharp declines at 400–500°C and 600–700°C.(3)Thermal damage stems from the differences in the high-temperature behavior of minerals,including dehydration,phase transformation,and differential expansion.
文摘This article summarizes recent domestic literature on the use of Huangqin(Scutellaria baicalensis)in the treatment of lung cancer.It reviews the mechanism of action of Huangqin in treating lung cancer from six aspects:inhibiting the growth of lung cancer cells,inducing apoptosis of lung cancer cells,inducing autophagy of lung cancer cells,inhibiting the migration of lung cancer cells,promoting the differentiation of lung cancer cells,and improving immune function.The aim is to provide a reference for the material basis and further research on the anti-inflammatory and anti-tumor efficacy of Huangqin.
基金supported by the National Natural Science Foundation of China(Nos.42020104001,42327806 and 42177354).
文摘Brown carbon(BrC)has attracted widespread attention because of its strong absorption of solar radiation in the ultraviolet-visible wavelength range,which causes adverse impacts on human health.Originally,BrC was a physically defined class of substances.However,current research has gradually shifted towards the identification of its chemical groups,because its light-absorbing capability,chemical properties and health effects mainly depend on the chemical composition of its chromophores.Therefore,this review mainly focuses on the chemical understanding of BrC based on chromophores,and the secondary formation mechanism of chromophores,photosensitized reactions,and human health effects of BrC were detailly summarized.Firstly,BrC chromophores are divided into five categories:nitrogen-heterocycles,nitrogen-chain,aromatic species,oligomers and sulfur-containing organic compounds.Different chromophore precursor species exhibit variations,and their formation mechanisms are also distinct.Secondly,BrC can trigger the production of secondary organic aerosol(SOA)precursors or cause SOA growth because BrC is an important component of light-absorbing particles formed during incomplete combustion of biomass and fossil fuels,potentially exerting adverse effects on human health.Finally,developing sufficiently separated methods for BrC and refining algorithms and machine learning can lead to a more effective understanding of the chemical composition of chromophores,thus enabling better evaluation of the atmospheric effects and health impacts of BrC.In all,this review provides new insights into the categories of BrC chromophores and new advance in secondary formation mechanisms,photosensitized reactions,and human health effects on the basis of chemical structures.
基金supported by the National Natural Science Foundation of China(No.52368058)Guangxi Science and Technology Program(Gui Ke AB23026067).
文摘Aluminum industrial solid waste represents a highly abundant yet underutilized resource.Its incorporation into asphalt pavement applications can effectively reduce the exploitation of natural resources and mitigate environmental issues caused by waste accumulation.This paper focuses on typical solid waste resources generated by the aluminum industry,summarizing the latest research progress in their application within the asphalt pavement industry and proposing key directions for future attention.The physicochemical properties of red mud(RM),spent aluminum electrolytic cathode materials,and secondary aluminum dross(SAD)are reviewed.The effects and mechanisms of RM,spent aluminum electrolytic cathode materials,and SAD on the performance of asphalt and its mixtures are elaborated.RM significantly enhances the aging resistance of asphalt,the hightemperature rheological properties of asphalt mastic,and the rutting resistance of asphalt mixtures.Spent aluminum electrolytic cathode materials require the removal of fluorides and cyanides before further application in asphalt pavement.SAD effectively improves the dynamic stability of asphalt mixtures.This review presents the first systematic summary of key scientific challenges and technical bottlenecks in the application of aluminum industrial solid waste in asphalt pavements.It clarifies that future research should prioritize waste pretreatment technologies,performance regulation mechanisms,and life cycle environmental impact assessments.These contributions provide essential theoretical foundations and technical guidance for advancing the resource utilization of aluminum industrial solid waste,holding substantial significance for promoting the development of green transportation infrastructure.
基金Project(52202426)supported by the National Natural Science Foundation of ChinaProjects(15205723,15226424)supported by the Research Grants Council(RGC)of the Hong Kong Special Administrative Region,ChinaProject(KBBY1)supported by the Innovation and Technology Commission of the Hong Kong Special Administrative Region。
文摘This study innovatively employs functional near-infrared spectroscopy(fNIRS)technology to investigate passengers’brain responses to various external stimuli during high-speed train operations,assessing their impact on passenger comfort.Three stimuli are examined:passing through tunnels,sonic booms at tunnel exits,and two trains meeting within the tunnel.The analysis of environmental variables,including cabin noise,cabin-to-external pressure,and cabin-to-body acceleration,reveals that changes in auditory and pressure levels during the tunnel experience led to an 87%increase in oxygenated hemoglobin(HbO)levels in the temporal lobe(TL).This reflects a brief discomfort that subsides as passengers adapt,with HbO levels nearly returning to pre-tunnel levels upon exit.Among the stimuli,the sonic boom triggered the most significant neural response,with HbO fluctuations increased by 175%.In contrast,the impact of train meetings was minor,yielding an average HbO increase of only 14.21%.Connectivity analysis further shows significant enhancements in brain functional connectivity during tunnel entrance and sonic boom scenarios,with increases of 52%and 80%,respectively.Our findings contribute to passenger comfort assessment by establishing objective neurophysiological measures that quantify previously subjective experiences.The application of fNIRS in this dynamic environment creates new possibilities for evidence-based comfort optimization in railway design.
文摘Osteoarthritis(OA)is a kind of joint diseases characterized by fibrosis,ulceration,and loss of articular cartilage and articular surrounding tissues caused by various factors,the main symptoms of OA include joint pain,joint stiffness,and loss of joint function,and OA has the higher prevalence rate and has been listed as one of the four major disabling diseases,seriously affecting people’s lives and health.Traditional Chinese medicine(TCM)is a comprehensive science based on the theory of Yin Yang(one TCM theory,the material world is believed to be nurtured,developed,and changed under the influence of Yin and Yang)and Five Elements(The five most basic substances-wood,fire,earth,metal,and water-are considered indispensable elements that make up the world),based on TCM theory and practical experience it can play the important role in prevention,diagnosis,treatment,rehabilitation,and health care in OA,exhibit the great application potential for OA treatment.In this review,we have summarized the recent research progress in the application of TCM in OA,including an analysis of underlying mechanisms,application limitations,and potential solutions,found that the material basis and targets of the therapeutic component of TCM,the quality control and the mechanism of TCM application in OA are not very clear,which may become the application limitation of TCM in OA.We hope that this review will offer valuable insights to researchers in the field.
基金jointly funded by the National Science Foundation of China(No.42405069)the University Natural Sciences Research Project of Anhui Province(Nos.2023AH052201 and 2023AH052184)+1 种基金the 2023 Talent Research Fund Project of Hefei University(No.23RC01)the Technical Development Project of Hefei University(Nos.902/22050124128,902/22050124148 and 902/22050124250)。
文摘Atmospheric turbulence is an important parameter affecting laser atmospheric transmission.This paper reports on a self-developed atmospheric turbulence detection Li DAR system(scanning differential image motion Li DAR(DIM-Li DAR)system).By designing and simulating the optical system of atmospheric turbulence detection Li DAR,the basic optical imaging accuracy has been determined.
基金supported by the National Key Research and Development of China(No.2018YFA0702804).
文摘Over the past several decades,the integration of IONs into EP emerged as an effective method for enhancing its mechanical properties.Nevertheless,challenges remain,especially with u-IONs,where the interfacial strength with EP is suboptimal,resulting in aggregation within the EP matrix and a subsequent deterioration in the mechanical performance of u-ION/EP nanocomposites.In this comprehensive review,we explored advanced chemical modification techniques tailored for IONs incorporated into EP,providing a detailed examination of the mechanical characteristics of surface cm-ION/EP nanocomposites.This review investigates various chemical modification methods and their distinct impacts on the mechanical attributes of the resulting EP nanocomposites.Special emphasis is given to addressing the persistent challenges of inadequate interfacial strength and aggregation.Furthermore,this article examines prospective surface modification approaches for inorganic oxide nanoparticles,offering a visionary outlook on methods to improve the mechanical performance of EP in future.
基金supported by the National Natural Science Foundation of China(Grant Nos.NSFC 82273405,and 81972306)supported partly by the Guangxi Nature Sciences grants(Grant No.2018GXNSFAA138028)the Guangxi Medical University Training Program for Distinguished Young Scholars.
文摘Objective:Hyper-progression recurrence(HPR)after hepatectomy is a specific recurrence pattern associated with extremely poor prognosis in patients with hepatocellular carcinoma(HCC).This study was aimed at investigating the probable risk factors and establishing comprehensive models for formulating clinical strategies.Methods:Overall,16,158 patients with HCC from 8 hospitals were screened,among whom 3,125 patients who underwent R0 resection were included,and divided into development(n=2,113)and validation(n=1,012)cohorts.A comprehensive study of HPR predictive models and biological features was conducted.Results:Among the 3,125 enrolled patients,506(16.19%)developed HPR.The influence of HPR on extremely poor prognosis was reflected by recurrence features,adverse effects on systemic and liver function,and limited therapeutic options.Nine variables closely associated with HPR were identified,and incorporated into nomogram and conditional inference tree models,which successfully achieved pre-and post-operative HPR risk stratification and facilitated clinical decision-making.Multi-dimensional verification also confirmed the predictive accuracy of model combinations and their reliability in clinical applications.Furthermore,biological analyses revealed that HCCs with HPR exhibited hyperactive biological processes,inactive metabolism,and immune exhaustion features,together with high MYCN/HMGA2 co-expression,thereby enhancing understanding of the molecular events leading to HPR and providing valuable knowledge for HPR management.Conclusions:HPR after hepatectomy is associated with extremely poor prognosis and requires substantial attention.We constructed comprehensive predictive models and propose a clinical strategy for guiding HPR prevention and management.
文摘1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging.
基金supported by the National Natural Science Foundation of China(32271580,42020104009)the Fundamental Research Funds for Zhejiang Provincial Universities and Research Institutes(JX6311101923)。
文摘Mytilus contain abundant antimicrobial peptides(AMPs)that play a key role in the innate immunity.However,heterologous production of these AMPs remains challenging due to their short sequences,multiple disulfide bonds,and high content of cationic amino acids,which hinder functional expression in prokaryotic systems such as Escherichia coli.To establish a eukaryotic recombinant expression system for the AMPs of mussel and obtain recombinant mussel AMPs for subsequent studies,we reported the successful recombinant expression of myticofensin B1,a novel defensin-like AMP identified previously in Mytiluscoruscus,using the eukaryotic host Pichia pastoris.The codon-optimized gene encoding the mature myticofensin-B1(composed of 65 amino acid residues,including 6 conserved cysteine residues)was cloned into a pPICZαA vector and expressed in P.pastoris GS115.Structural fidelity of the recombinant peptide was confirmed by liquid chromatography-tandem mass spectrometry(LC-MS/MS),showing a molecular weight of 8849.9 Da,which was consistent with the theoretical prediction.Functional assays demonstrated a broad-spectrum antimicrobial activity of the recombinant myticofensin-B1,with stronger inhibition against Gram-negative bacteria.Scanning electron microscopy revealed different effects of the recombinant myticofensin-B1 against different bacteria.In addition,the recombinant myticofensin-B1 exhibited a very low hemolytic activity against sheep red blood cells and weak cytotoxicity against human A549 lung cancer cells.This study establishes P.pastoris as a powerful platform to produce functional mussel AMP and highlights the potential of the recombinant myticofensin-B1 as a therapeutic agent for aquaculture pathogens and infections.
