The microstructure transformation and precipitation behavior of nano-carbides in Ti microalloyed steel during isothermal process were studied by a compression test on a Gleeble 3800 thermomechanical simulator and anal...The microstructure transformation and precipitation behavior of nano-carbides in Ti microalloyed steel during isothermal process were studied by a compression test on a Gleeble 3800 thermomechanical simulator and analyzed by optical microscopy,transmission electron microscopy and other methods.The results show thatγ→αphase transformation and TiC precipitation take place in Ti microalloyed steel during the isothermal process,and time–temperature–transformation curve and precipitation–time–temperature(PTT)curve are all of“C”-type.During the isothermal process,the interphase precipitation of TiC mostly occurs at the period of the phase transformation,and the random precipitation of TiC mostly occurs on the ferrite after the phase transformation.The increment in yield strength at the initial stage of isothermal transformation mainly comes from phase transformation strengthening.With the increase in isothermal time,the precipitation hardening effect becomes more important for nucleation and growth of titanium carbides and eventually reaches the maximum value at the precipitation finished point of the PTT curve.展开更多
Objective:This study aimed to investigate the impact of Jinfeng Pills on the receptivity of a thin endometrium in rats and elucidate its mechanism of action.Methods:A thin endometrial model was established in female S...Objective:This study aimed to investigate the impact of Jinfeng Pills on the receptivity of a thin endometrium in rats and elucidate its mechanism of action.Methods:A thin endometrial model was established in female Sprague-Dawley rats. The rats were randomly assigned to the control, model, estradiol valerate, and Jinfeng Pill groups. Histological evaluation using hematoxylin and eosin staining was performed to assess morphological changes in the endometrium under light microscopy. Enzyme-linked immunosorbent assay was used to measure vascular endothelial growth factor (VEGF), estrogen, and progesterone levels in rat serum. Immunohistochemical analysis was used to examine morphological alterations in the endometrium. Immunofluorescence and quantitative polymerase chain reaction were employed to analyze the expression of VEGF, platelet endothelial cell adhesion molecule (CD31), β-catenin, leukemia inhibitory factor (LIF), and homeobox gene A10 (HOXA10) proteins and mRNA in endometrial tissue.Results:Compared to the model group, the Jinfeng Pill group exhibited a thicker endometrium characterized by pronounced undulating architecture, increased glandular and vascular density, and greater endometrial volume. There was a statistically significant increase in serum VEGF levels in the Jinfeng Pill group ( P <0.05). Additionally, protein levels and mRNA expression of VEGF, CD31, HOXA10, β-catenin, and LIF were significantly high in the endometrium of the Jinfeng Pill group ( P <0.05).Conclusion:Jinfeng Pills enhance the receptivity of a thin endometrium in rats by upregulating protein levels and mRNA expression of VEGF, CD31, HOXA10, β-catenin, and LIF in the endometrium.展开更多
文摘The microstructure transformation and precipitation behavior of nano-carbides in Ti microalloyed steel during isothermal process were studied by a compression test on a Gleeble 3800 thermomechanical simulator and analyzed by optical microscopy,transmission electron microscopy and other methods.The results show thatγ→αphase transformation and TiC precipitation take place in Ti microalloyed steel during the isothermal process,and time–temperature–transformation curve and precipitation–time–temperature(PTT)curve are all of“C”-type.During the isothermal process,the interphase precipitation of TiC mostly occurs at the period of the phase transformation,and the random precipitation of TiC mostly occurs on the ferrite after the phase transformation.The increment in yield strength at the initial stage of isothermal transformation mainly comes from phase transformation strengthening.With the increase in isothermal time,the precipitation hardening effect becomes more important for nucleation and growth of titanium carbides and eventually reaches the maximum value at the precipitation finished point of the PTT curve.
基金Tong Yi Tang Pharmaceutical Co.,Ltd.,Wu Jieping Foundation Clinical Research Special Project(320.6750.2021-19-2)Fujian Province Natural Science Foundation Project(2023J011619)。
文摘Objective:This study aimed to investigate the impact of Jinfeng Pills on the receptivity of a thin endometrium in rats and elucidate its mechanism of action.Methods:A thin endometrial model was established in female Sprague-Dawley rats. The rats were randomly assigned to the control, model, estradiol valerate, and Jinfeng Pill groups. Histological evaluation using hematoxylin and eosin staining was performed to assess morphological changes in the endometrium under light microscopy. Enzyme-linked immunosorbent assay was used to measure vascular endothelial growth factor (VEGF), estrogen, and progesterone levels in rat serum. Immunohistochemical analysis was used to examine morphological alterations in the endometrium. Immunofluorescence and quantitative polymerase chain reaction were employed to analyze the expression of VEGF, platelet endothelial cell adhesion molecule (CD31), β-catenin, leukemia inhibitory factor (LIF), and homeobox gene A10 (HOXA10) proteins and mRNA in endometrial tissue.Results:Compared to the model group, the Jinfeng Pill group exhibited a thicker endometrium characterized by pronounced undulating architecture, increased glandular and vascular density, and greater endometrial volume. There was a statistically significant increase in serum VEGF levels in the Jinfeng Pill group ( P <0.05). Additionally, protein levels and mRNA expression of VEGF, CD31, HOXA10, β-catenin, and LIF were significantly high in the endometrium of the Jinfeng Pill group ( P <0.05).Conclusion:Jinfeng Pills enhance the receptivity of a thin endometrium in rats by upregulating protein levels and mRNA expression of VEGF, CD31, HOXA10, β-catenin, and LIF in the endometrium.
