This paper introduces the Integrated Security Embedded Resilience Architecture (ISERA) as an advanced resilience mechanism for Industrial Control Systems (ICS) and Operational Technology (OT) environments. The ISERA f...This paper introduces the Integrated Security Embedded Resilience Architecture (ISERA) as an advanced resilience mechanism for Industrial Control Systems (ICS) and Operational Technology (OT) environments. The ISERA framework integrates security by design principles, micro-segmentation, and Island Mode Operation (IMO) to enhance cyber resilience and ensure continuous, secure operations. The methodology deploys a Forward-Thinking Architecture Strategy (FTAS) algorithm, which utilises an industrial Intrusion Detection System (IDS) implemented with Python’s Network Intrusion Detection System (NIDS) library. The FTAS algorithm successfully identified and responded to cyber-attacks, ensuring minimal system disruption. ISERA has been validated through comprehensive testing scenarios simulating Denial of Service (DoS) attacks and malware intrusions, at both the IT and OT layers where it successfully mitigates the impact of malicious activity. Results demonstrate ISERA’s efficacy in real-time threat detection, containment, and incident response, thus ensuring the integrity and reliability of critical infrastructure systems. ISERA’s decentralised approach contributes to global net zero goals by optimising resource use and minimising environmental impact. By adopting a decentralised control architecture and leveraging virtualisation, ISERA significantly enhances the cyber resilience and sustainability of critical infrastructure systems. This approach not only strengthens defences against evolving cyber threats but also optimises resource allocation, reducing the system’s carbon footprint. As a result, ISERA ensures the uninterrupted operation of essential services while contributing to broader net zero goals.展开更多
This article analyzes the application strategies of Building Information Modeling(BIM)support technology in a first-class highway reconstruction and expansion project based on its actual situation.According to the bas...This article analyzes the application strategies of Building Information Modeling(BIM)support technology in a first-class highway reconstruction and expansion project based on its actual situation.According to the basic situation of BIM technology and its application goals in this project,it explores application strategies such as BIM model construction,BIM prefabricated structural model deepening and schedule simulation,BIM collision detection,and BIM tunnel pre-construction simulation.Through this analysis,it is hoped to provide a reference for the rational application of BIM support technology and ensure the high-quality and efficient completion of first-class highway reconstruction and expansion projects.展开更多
The detrimental phase transformations of sodium layered transition metal oxides(Na_(x)TMO_(2))during desodiation/sodiation seriously suppress their practical applications for sodium ion batteries(SIBs).Undoubtedly,com...The detrimental phase transformations of sodium layered transition metal oxides(Na_(x)TMO_(2))during desodiation/sodiation seriously suppress their practical applications for sodium ion batteries(SIBs).Undoubtedly,comprehensively investigating of the dynamic crystal structure evolutions of Na_(x)TMO_(2)associating with Na ions extraction/intercalation and then deeply understanding of the relationships between electrochemical performances and phase structures drawing support from advanced characterization techniques are indispensable.In-situ high-energy X-ray diffraction(HEXRD),a powerful technology to distinguish the crystal structure of electrode materials,has been widely used to identify the phase evolutions of Na_(x)TMO_(2)and then profoundly revealed the electrochemical reaction processes.In this review,we begin with the descriptions of synchrotron characterization techniques and then present the advantages of synchrotron X-ray diffraction(XRD)over conventional XRD in detail.The optimizations of structural stability and electrochemical properties for P2-,O3-,and P2/O3-type Na_(x)TMO_(2)cathodes through single/dual-site substitution,high-entropy design,phase composition regulation,and surface engineering are summarized.The dynamic crystal structure evolutions of Na_(x)TMO_(2)polytypes during Na ion extraction/intercalation as well as corresponding structural enhancement mechanisms characterizing by means of HEXRD are concluded.The interior relationships between structure/component of Na_(x)TMO_(2)polytypes and their electrochemical properties are discussed.Finally,we look forward the research directions and issues in the route to improve the electrochemical properties of Na_(x)TMO_(2)cathodes for SIBs in the future and the combined utilizations of multiple characterization techniques.This review will provide significant guidelines for rational designs of high-performance Na_(x)TMO_(2)cathodes.展开更多
BIM technology has become an important tool in road and bridge design.Through the application of BIM technology,the entire bridge process can be modeled to form a virtual bridge form.Through the simulation of bridge c...BIM technology has become an important tool in road and bridge design.Through the application of BIM technology,the entire bridge process can be modeled to form a virtual bridge form.Through the simulation of bridge construction materials,construction techniques,and construction processes,a comprehensive analysis can be conducted to achieve visualization of the design and improve the efficiency of bridge design.This article mainly analyzes the advantages of BIM technology in bridge design,explores the application forms in bridge design,and proposes strategies to optimize bridge design,providing a certain reference for the improvement and optimization of bridge design work.展开更多
At present,transportation construction plays a certain promoting and driving role in the economic and social development of our country.At the same time,because of the accelerated pace of transportation construction,t...At present,transportation construction plays a certain promoting and driving role in the economic and social development of our country.At the same time,because of the accelerated pace of transportation construction,the traffic network structure of each region of China has gradually been optimized and perfected.This not only significantly improves people’s quality of life and living conditions,but also provides many conveniences for the transportation of goods.However,in the current process of highway construction and development in China,there is still a certain degree of danger,which will also significantly increase the probability of road safety problems occurring.Therefore,it is necessary to apply intelligent transportation technology to effectively enhance the safety of road use.As a result,this study provides a detailed analysis of the overview of intelligent transportation technology,the advantages of the application of intelligent transportation technology in traffic safety management,as well as an in-depth discussion of the role and application of intelligent transportation technology in traffic safety management.展开更多
Opto-electronics is rooted in the effects and principles of light,photons,and even photonic quasiparticles interaction with matter such as electronics systems,focusing on the generation,transmission,detection,and mani...Opto-electronics is rooted in the effects and principles of light,photons,and even photonic quasiparticles interaction with matter such as electronics systems,focusing on the generation,transmission,detection,and manipulation of energy and information.This field drives innovation across diverse technological domains,including advanced materials,devices,methods,instruments,and equipment that empower humanity to overcome significant challenges in observation,communication,computing,data storage,display technologies,and sustainable energy solutions.展开更多
The sustainable development of aquaculture industry is deeply constrained by pathogens and diseases,and traditional detection methods are difficult to adapt to the needs of intensive aquaculture due to low efficiency ...The sustainable development of aquaculture industry is deeply constrained by pathogens and diseases,and traditional detection methods are difficult to adapt to the needs of intensive aquaculture due to low efficiency and insufficient sensitivity.This article reviews the progress of rapid detection technology for aquatic pathogens based on molecular biology,immunology,biosensors,etc.,and analyzes the application value of innovative methods such as isothermal amplification and CRISPR.This technology injects core momentum into the new quality productivity of fisheries through early and precise identification of pathogens:reducing aquaculture losses to improve resource efficiency,promoting the transformation of aquaculture models to data-driven,ensuring the safety of aquatic products to enhance the competitiveness of the industry chain.The current technology has shortcomings such as lagging standardization,weak on-site anti-interference ability,and insufficient recognition of new pathogens.In the future,we need to focus on technological integration and innovation,intelligent upgrading,and standardization construction,promote technology from laboratories to industrial applications,and provide continuous support for the high-quality development of fisheries.展开更多
The continuous increase in petroleum-based plastic food packaging has led to numerous environmental concerns.One effort to reduce the use of plastic packaging in food is through preservation using biopolymer-based pac...The continuous increase in petroleum-based plastic food packaging has led to numerous environmental concerns.One effort to reduce the use of plastic packaging in food is through preservation using biopolymer-based packaging.Among the many types of biopolymers,chitosan is widely used and researched due to its non-toxic,antimicrobial,and antifungal properties.Chitosan is widely available since it is a compound extracted from seafood waste,especially shrimps and crabs.The biodegradability and biocompatibility of chitosan also showed good potential for various applications.These characteristics and propertiesmake chitosan an attractive biopolymer to be implemented as food packaging in films and coatings.Chitosan has been tested in maintaining and increasing the shelf life of food,especially seafood such as fish and shrimp,and post-harvest products such as fruits and vegetables.In addition to its various advantages,the properties and characteristics of chitosan need to be improved to produce optimal preservation.The properties and characteristics of chitosan are improved by adding various types of additive materials such as biopolymers,plant extracts,essential oils,and metal nanoparticles.Research shows that material additives and nanotechnology can improve the quality of chitosan-based food packaging for various types of food by enhancing mechanical properties,thermal stability,antimicrobial activity,and antioxidant activity.This review provides a perspective on the recent development and properties enhancement of chitosan composite with additives and nanotechnology,as well as this material’s challenges and prospects as food packaging.展开更多
Ultra-high-strength aluminumalloy profile is an ideal choice for aerospace structuralmaterials due to its excellent specific strength and corrosion resistance.However,issues such as uneven metal flow,stress concentrat...Ultra-high-strength aluminumalloy profile is an ideal choice for aerospace structuralmaterials due to its excellent specific strength and corrosion resistance.However,issues such as uneven metal flow,stress concentration,and forming defects are prone to occur during their extrusion.This study focuses on an Al-Zn-Mg-Cu ultra-high-strength aluminum alloy profile with a double-U,multi-cavity thin-walled structure.Firstly,hot compression experiments were conducted at temperatures of 350○C,400○C,and 450○C,with strain rates of 0.01 and 1.0 s^(−1),to investigate the plastic deformation behavior of the material.Subsequently,a 3D coupled thermo-mechanical extrusion simulation model was established using Deform-3D to systematically analyze the influence of die structure and process parameters on metal flow velocity,effective stress/strain,and temperature distribution.The simulation revealed significant velocity differences,stress concentration,and uneven temperature distribution.Key parameters,including mesh density,extrusion ratio,die fillet,and bearing length,were optimized through full-factorial experiments.This optimization,combined with a stepped flow-guiding die design,effectively improved the metal flow pattern during extrusion.Trial production based on both the initial and optimized parameters were carried out.A comparative analysis demonstrates that the optimized scheme results in a final profile whose cross-section matches the target design closely,with complete filling of complex features and no obvious forming defects.This research provides a valuable reference for the extrusion process optimization and die design of complex-section profiles made from ultra-high-strength aluminum alloys.展开更多
[Objectives]This study was conducted to establish a quantitative assessment method for the textural quality of chieh-qua fruit.[Methods]Using two modes of a texture analyzer,namely TPA(texture profile analysis)and pun...[Objectives]This study was conducted to establish a quantitative assessment method for the textural quality of chieh-qua fruit.[Methods]Using two modes of a texture analyzer,namely TPA(texture profile analysis)and puncture,the index data of the fruit were obtained by setting different trigger forces,deformation levels,test speeds,as well as puncture speeds and puncture depths.The data included TPA hardness,adhesiveness,springiness,cohesiveness,gumminess,chewiness,resilience,as well as skin hardness,skin toughness,flesh hardness,fracturability,and compactness.[Results]Different deformation levels had a significant impact on all parameters.Hardness,adhesiveness,gumminess and chewiness showed a trend of first increasing and then decreasing with the deformation level increasing.When the deformation level was 30%,the adhesiveness,gumminess and chewiness reached their maximum values.When the deformation level was 50%,TPA hardness reached its maximum.When the compression speed was 3 mm/s,the measured values of TPA hardness,adhesiveness,chewiness,and resilience were at their maximums.The skin hardness varied significantly under different trigger forces.When the trigger force was 15 g,the skin hardness reached a maximum value of 944.63 g,and the skin toughness,flesh hardness,fracturability,and compactness also reach their maximum values respectively.When the puncture depth was 12 mm,the flesh hardness and skin toughness reached their maximums of 682.51 g and 1.82 mm,respectively.In the TPA mode,the flesh hardness of chieh-qua showed an extremely significant negative correlation with springiness,cohesiveness,and resilience(P<0.01).The fruit fracturability detected by puncture had an extremely significant positive correlation with compactness(P<0.01).[Conclusions]The evaluation method for measuring chieh-qua texture by combining TPA and the puncture mode could accurately and quantitatively reflect the differences in the flesh texture quality of chieh-qua.The optimal parameters for texture measurement of chieh-qua fruit were determined as a 15 g trigger force with 50%deformation and a 3 mm/s compression speed in TPA mode,and a 15 g trigger force with a 12 mm puncture depth in puncture mode.Puncture speed was found to have no significant effect on the texture indices of chieh-qua.展开更多
One of the main issues in designing optimum tapered cascades for uranium enrichment for annual fuel production in a power reactor is whether to employ large(fat)or small(thin)cascades.What will be the permissible and ...One of the main issues in designing optimum tapered cascades for uranium enrichment for annual fuel production in a power reactor is whether to employ large(fat)or small(thin)cascades.What will be the permissible and optimal ranges of the number of machines that can be used in a cascade?For the first time,the permissible and optimal ranges of the number of gas centrifuges that can be utilized in a cascade were investigated using two types of centrifuges,and the performance of small and large tapered cascades was discussed.The particle swarm optimization algorithm(PSO)has been used to optimize tapered cascades.The results show:(1)For the first centrifuge,41 cascades(91≤n≤4897)and for the second centrifuge,49 cascades(18≤n≤3839)with small and large sizes can be used in enrichment facilities,and the best cascade for them has 530(with 23 stages)and 39(with 7 stages)centrifuges,respectively.(2)For both centrifuges,when 600≤n(number of centrifuges=n),the large cascade performance changes are relatively insignificant.(3)For both types of gas centrifuges,the annual los s of separation power in enrichment facilities is approximately 1.25%-4.82%of the total separation work required.展开更多
Subcritical reactors(SCRs)or subcritical assemblies(SCAs)are the main infrastructure for designing power reactors.These reactors are widely used for training and research because of their high level of inherent safety...Subcritical reactors(SCRs)or subcritical assemblies(SCAs)are the main infrastructure for designing power reactors.These reactors are widely used for training and research because of their high level of inherent safety.The objective of this study is to design a subcritical reactor using a pressurized water reactor(PWR)conventional fuel following two safety points.In the first approach,deeply placed SCR cores with an infinite multiplication factor(k_(∞))of less than unity were identified using the DRAGON lattice code.In the second approach,subcritical reactor cores with an effective multiplication factor(k_(eff))of less than unity were determined by coupling the cell calculations of the DRAGON lattice code and core calculations of the DONJON code.For the deeply subcritical reactor design,it was found that the reactor would remain inherently subcritical while using fuel rods with ^(235)U enrichment of up to 0.9%,regardless of the pitch of the fuel rods.In the second approach,the optimal pitches(1.3 to 2.3 cm)were determined for different fuel enrichment values from 1 to 5%.Subsequently,the k_(eff) was obtained for a fuel rod arrangement of 8×8 to 80×80,and the states in which the reactor would be subcritical were determined for different fuel enrichments at the corresponding optimal pitch.To validate the models used in the DRAGON and DONJON codes,the k_(eff) of the Isfahan Light Water Subcritical Reactor(LWSCR)was experimentally measured and compared with the results of the calculations.Finally,the effects of fuel and moderator temperature changes were investigated to ensure that the designed assemblies remained in the subcritical state at all operational temperatures.展开更多
To address the issue of incorrect fusion results caused by conflicting evidence due to inaccurate evidence and incomplete recognition frameworks in radar airborne target tactical intention recognition,a spatiotemporal...To address the issue of incorrect fusion results caused by conflicting evidence due to inaccurate evidence and incomplete recognition frameworks in radar airborne target tactical intention recognition,a spatiotemporal evidence fusion algorithm is proposed.To resolve the conflict evidence fusion problem caused by inaccurate evidence,the algorithm performs discounting of evidence from both spatial and temporal dimensions.Spatial discounting is influenced by both inter-evidence inconsistency and intra-evidence inconsistency,while temporal discounting is determined by time intervals and information entropy.For the problem of conflicting evidence fusion due to an incomplete recognition framework,an open recognition architecture based on dynamic composite focal elements is proposed.This approach allocates some conflicting information to temporary composite focal elements,avoiding excessive basic probability assignment(BPA)of the empty set after fusion,which can lead to deviations from the actual fusion results.Simulation experiments comparing various methods indicate that the proposed method can effectively improve target intention recognition accuracy and demonstrates good stability.展开更多
The Southern Advanced Photon Source(SAPS)is a diffraction-limited synchrotron light source under design,which employs longitudinal injection as its primary injection scheme.This kind of injection scheme requires that ...The Southern Advanced Photon Source(SAPS)is a diffraction-limited synchrotron light source under design,which employs longitudinal injection as its primary injection scheme.This kind of injection scheme requires that the injected beam has a short bunch length and low emittance,and the preferred injector should offer high stability and low cost.Therefore,an injector based on a booster synchrotron was developed.The proposed injector includes a 250 MeV linac,a booster synchrotron that ramps the beam energy to 3.5 GeV,and two beam transport lines to ensure efficient beam delivery and beam quality preservation.The linac utilizes a thermionic high-voltage DC gun for reliable operation and features a bunching system with an advanced focusing system to preserve the emittance.To meet the injection requirements of the SAPS,a comprehensive design for the booster has been conducted.The booster synchrotron employs a threefold lattice structure,incorporating modified theoretical minimum emittance cells with a small momentum compaction factor and a high voltage to achieve an emittance of 3.98 nm rad and a bunch length of 4.8 mm.The injector has the potential to deliver a high charge,reducing the injection period of the storage ring to less than 1 min.Simulations demonstrated the expected performance,with a transmission efficiency of 90%,confirming its capability to meet the injection requirement of the SAPS storage ring.This design offers a stable and efficient solution for the SAPS.展开更多
Alzheimer’s disease-associated transcriptomic landscapes have been defined in brain tissue.However,changes in blood RNA and their clinical relevance remain poorly understood.In this study,we developed an RNA profile ...Alzheimer’s disease-associated transcriptomic landscapes have been defined in brain tissue.However,changes in blood RNA and their clinical relevance remain poorly understood.In this study,we developed an RNA profile based on 1468 blood samples from both human and mouse studies,which include bulk RNA sequencing(RNA-seq),microRNA-seq,and single-cell RNA-seq data.We developed a comprehensive analysis pipeline that conducted over 11 million comparisons and correlations to identify more than 20,000 blood features.With these findings,we established a blood RNA database related to Alzheimer’s disease,RNAs in Blood of AD(RBAD,http://www.bioinform.cn/RBAD/).Using RBAD,we initially validated well-established Alzheimer’s disease-related pathways,including olfactory transduction.We then observed a decrease in both the proportion and functionality of erythroid cells,likely attributed to their elevated CD45 levels and interactions with GZMK^(+)CD8^(+)T cells.Furthermore,we identified 449 blood RNAs linked to patients’overall survival,along with two mRNAs(H4C3 and CTU1)associated with cognitive decline.In summary,RBAD is the first web-based analysis platform dedicated to investigating blood RNA changes in Alzheimer’s disease,and provides valuable insights into potential peripheral biomarkers and pathogenic mechanisms related to Alzheimer’s disease.展开更多
To ensure the safe transportation of radioactive materials,numerous countries have established specific standards.For the transfer of fissile materials,it is imperative that the material within the packaging remains i...To ensure the safe transportation of radioactive materials,numerous countries have established specific standards.For the transfer of fissile materials,it is imperative that the material within the packaging remains in a subcritical state during routine,normal,and accidental transport conditions.In the event of an accident,the rods within the storage tank may become rearranged,introducing uncertainty that must be accounted for to ensure that criticality analysis results are conservative.Historically,this uncertainty was addressed overly conservatively due to limited research on non-uniform arrangement scenarios,which proved unsuitable for criticality safety analysis of spent fuel packages.This paper introduced three distinct methods to non-uniformly rearrange fuel rods—Uniform Arrangement by Blocks,Layer-by-Layer Determination,and Birdcage Deformation—and meticulously evaluates the influences of rod rearrangement on the effective multiplication factor of neutrons,k eff,utilizing the Monte Carlo method.Ultimately,this study presents a holistic method capable of encompassing the entire spectrum of potential effects stemming from the rearrangement of fuel rods during rods mispositioning accident.By augmenting the safety margin,this approach proves to be adeptly suited for the criticality safety analysis of nuclear fuel transport containers.展开更多
Protective hardware is essential for mitigating damage caused by unavoidable falls in humanoid robots.Despite notable progress in fall protection hardware,the theoretical foundation for modeling and the feasibility of...Protective hardware is essential for mitigating damage caused by unavoidable falls in humanoid robots.Despite notable progress in fall protection hardware,the theoretical foundation for modeling and the feasibility of conducting full-scale fall experiments on robots or their surrogates remain somewhat limited.This paper proposes a method for optimizing the thickness of Expandable Polyethylene(EPE),which is used as back protection for the Chubao humanoid robot,based on small-scale impact test data to predict full-scale behavior.The optimal thickness is defined as a balance between compact design and protective effectiveness.An equivalent impact model characterized by four parameters:contact area S,mass m,fall height h,and cushioning material thickness d is introduced to describe impact conditions.The relationship between the peak impact acceleration ap and material thickness d,which forms the core of the method and gives rise to the name AP-D,is analyzed through their plotted curves.After introducing three characteristic parameters and two correction fac-tors,the relationship among the aforementioned variables is derived.Subsequently,both the optimal thickness do and its corresponding peak impact acceleration aop are predicted via nonlinear and linear regression models.Finally,the accuracy and effectiveness of the theoretically derived optimal thickness are validated on both a dummy and the actual robot.With the cushioning material applied,the peak chest acceleration is reduced to 41.57g for the dummy and 32.08g for the robot.展开更多
Beer is a prominent fermented food product and is regarded as the one of most widely consumed beverage globally.There is a dearth of studies examining the impact of different types of beer with intricate components as...Beer is a prominent fermented food product and is regarded as the one of most widely consumed beverage globally.There is a dearth of studies examining the impact of different types of beer with intricate components as a comprehensive intervention on human health and immune status.This study used a 14-day continuous drinking intervention consisting of 5 beers,namely white beer,India pale ale(IPA),Pilsner,non-alcoholic beer,and premium lager beer.Surprisingly,our findings indicate that consuming white beer has little impact on the gut microbiota and physiological condition of mice,whereas consuming other types of beer leads to an increase in Lactobacillus and a decrease in Lachnospiraceae.In addition,we devised an extended feeding experiment to investigate the comparative safety and health benefits of consuming white beer.The research showed that when mice drank excessive quantities of white beer over 42 days,the intestines of the mice had more Prevotellaceae and the Firmicutes to Bacteroidetes ratio(F/B ratio)had a decline from 1.29 to 0.38.The levels of acetic acid,propionic acid,and isobutyric acid increased from 1.0,0.27,and 0.015 mg/g to 1.28,0.38,and 0.037 mg/g,respectively(P<0.05).There were no significant changes observed in the levels of most measured cytokines in the colon tissue of mice that consumed beer,however,there was an increase in the concentration of the inflammatory factor tumor nesrosis factor-α(TNF-α)from 135.86 pg/mL in the control group to 189.78 pg/mL in the white beer group(P<0.01).These results give us real-world proof that we can use to study how different beers affect the host’s health and satisfaction in future research.展开更多
The synthesis of high-quality heteroepitaxial diamond films on iridium composite substrates is a critical step toward advancing diamond for electronic and optical applications.Microwave plasma chemical vapor depositio...The synthesis of high-quality heteroepitaxial diamond films on iridium composite substrates is a critical step toward advancing diamond for electronic and optical applications.Microwave plasma chemical vapor deposition,combined with in situ optical emission spectroscopy,enables precise control over growth modes through plasma parameter tuning.In this study,we examine how methane concentration,microwave power,and gas pressure influence plasma species and,consequently,the growth modes of heteroepitaxial diamond by optical emission spectroscopy and scanning electron microscope.At low nucleation densities,increased methane concentrations promote the transition from faceted polyhedral to ballas structures,driven by elevated C_(2) radical concentrations in the plasma.Conversely,at higher nucleation densities,gas pressure,and substrate temperature dominate growth mode determination,leading to diverse morphologies,such as planar,polycrystalline,octahedral,and step-flow growth.These findings elucidate the interplay among plasma species,growth parameters,and growth mode,offering critical insights for optimizing growth conditions and preparing heteroepitaxial diamond films in a specific growth mode.展开更多
Human spinal cord organoids(hSCOs)offer a promising platform to study neurotrauma by addressing many limitations of traditional research models.These organoids provide access to human-specific physiological and geneti...Human spinal cord organoids(hSCOs)offer a promising platform to study neurotrauma by addressing many limitations of traditional research models.These organoids provide access to human-specific physiological and genetic mechanisms and can be derived from an individual's somatic cells(e.g.,blood or skin).This enables patient-specific paradigms for precision neurotrauma research,pa rticula rly relevant to the over 300,000 people in the United States living with chronic effects of spinal cord injury(SCI).展开更多
基金funded by the Office of Gas and Electricity Markets(Ofgem)and supported by De Montfort University(DMU)and Nottingham Trent University(NTU),UK.
文摘This paper introduces the Integrated Security Embedded Resilience Architecture (ISERA) as an advanced resilience mechanism for Industrial Control Systems (ICS) and Operational Technology (OT) environments. The ISERA framework integrates security by design principles, micro-segmentation, and Island Mode Operation (IMO) to enhance cyber resilience and ensure continuous, secure operations. The methodology deploys a Forward-Thinking Architecture Strategy (FTAS) algorithm, which utilises an industrial Intrusion Detection System (IDS) implemented with Python’s Network Intrusion Detection System (NIDS) library. The FTAS algorithm successfully identified and responded to cyber-attacks, ensuring minimal system disruption. ISERA has been validated through comprehensive testing scenarios simulating Denial of Service (DoS) attacks and malware intrusions, at both the IT and OT layers where it successfully mitigates the impact of malicious activity. Results demonstrate ISERA’s efficacy in real-time threat detection, containment, and incident response, thus ensuring the integrity and reliability of critical infrastructure systems. ISERA’s decentralised approach contributes to global net zero goals by optimising resource use and minimising environmental impact. By adopting a decentralised control architecture and leveraging virtualisation, ISERA significantly enhances the cyber resilience and sustainability of critical infrastructure systems. This approach not only strengthens defences against evolving cyber threats but also optimises resource allocation, reducing the system’s carbon footprint. As a result, ISERA ensures the uninterrupted operation of essential services while contributing to broader net zero goals.
文摘This article analyzes the application strategies of Building Information Modeling(BIM)support technology in a first-class highway reconstruction and expansion project based on its actual situation.According to the basic situation of BIM technology and its application goals in this project,it explores application strategies such as BIM model construction,BIM prefabricated structural model deepening and schedule simulation,BIM collision detection,and BIM tunnel pre-construction simulation.Through this analysis,it is hoped to provide a reference for the rational application of BIM support technology and ensure the high-quality and efficient completion of first-class highway reconstruction and expansion projects.
基金supported by the State Grid Corporation Science and Technology Project(No.5419-202158503A-0-5-ZN)。
文摘The detrimental phase transformations of sodium layered transition metal oxides(Na_(x)TMO_(2))during desodiation/sodiation seriously suppress their practical applications for sodium ion batteries(SIBs).Undoubtedly,comprehensively investigating of the dynamic crystal structure evolutions of Na_(x)TMO_(2)associating with Na ions extraction/intercalation and then deeply understanding of the relationships between electrochemical performances and phase structures drawing support from advanced characterization techniques are indispensable.In-situ high-energy X-ray diffraction(HEXRD),a powerful technology to distinguish the crystal structure of electrode materials,has been widely used to identify the phase evolutions of Na_(x)TMO_(2)and then profoundly revealed the electrochemical reaction processes.In this review,we begin with the descriptions of synchrotron characterization techniques and then present the advantages of synchrotron X-ray diffraction(XRD)over conventional XRD in detail.The optimizations of structural stability and electrochemical properties for P2-,O3-,and P2/O3-type Na_(x)TMO_(2)cathodes through single/dual-site substitution,high-entropy design,phase composition regulation,and surface engineering are summarized.The dynamic crystal structure evolutions of Na_(x)TMO_(2)polytypes during Na ion extraction/intercalation as well as corresponding structural enhancement mechanisms characterizing by means of HEXRD are concluded.The interior relationships between structure/component of Na_(x)TMO_(2)polytypes and their electrochemical properties are discussed.Finally,we look forward the research directions and issues in the route to improve the electrochemical properties of Na_(x)TMO_(2)cathodes for SIBs in the future and the combined utilizations of multiple characterization techniques.This review will provide significant guidelines for rational designs of high-performance Na_(x)TMO_(2)cathodes.
文摘BIM technology has become an important tool in road and bridge design.Through the application of BIM technology,the entire bridge process can be modeled to form a virtual bridge form.Through the simulation of bridge construction materials,construction techniques,and construction processes,a comprehensive analysis can be conducted to achieve visualization of the design and improve the efficiency of bridge design.This article mainly analyzes the advantages of BIM technology in bridge design,explores the application forms in bridge design,and proposes strategies to optimize bridge design,providing a certain reference for the improvement and optimization of bridge design work.
文摘At present,transportation construction plays a certain promoting and driving role in the economic and social development of our country.At the same time,because of the accelerated pace of transportation construction,the traffic network structure of each region of China has gradually been optimized and perfected.This not only significantly improves people’s quality of life and living conditions,but also provides many conveniences for the transportation of goods.However,in the current process of highway construction and development in China,there is still a certain degree of danger,which will also significantly increase the probability of road safety problems occurring.Therefore,it is necessary to apply intelligent transportation technology to effectively enhance the safety of road use.As a result,this study provides a detailed analysis of the overview of intelligent transportation technology,the advantages of the application of intelligent transportation technology in traffic safety management,as well as an in-depth discussion of the role and application of intelligent transportation technology in traffic safety management.
文摘Opto-electronics is rooted in the effects and principles of light,photons,and even photonic quasiparticles interaction with matter such as electronics systems,focusing on the generation,transmission,detection,and manipulation of energy and information.This field drives innovation across diverse technological domains,including advanced materials,devices,methods,instruments,and equipment that empower humanity to overcome significant challenges in observation,communication,computing,data storage,display technologies,and sustainable energy solutions.
基金supported by the National Modern Agricultural Industry Technology System(CARS-45-33)Innovation Team of Tianjin Freshwater Aquaculture Industry Technology System(ITTFRS2021000-002,ITTFRS2021000-001)+1 种基金Tianjin Science and Technology Plan Project(24KPHDRC00280,24ZYCGSN00250,23YDTPJC00420)the Open Fund Project of Key Laboratory of Ocean Observation Technology,MNR(No.2023klootA03).
文摘The sustainable development of aquaculture industry is deeply constrained by pathogens and diseases,and traditional detection methods are difficult to adapt to the needs of intensive aquaculture due to low efficiency and insufficient sensitivity.This article reviews the progress of rapid detection technology for aquatic pathogens based on molecular biology,immunology,biosensors,etc.,and analyzes the application value of innovative methods such as isothermal amplification and CRISPR.This technology injects core momentum into the new quality productivity of fisheries through early and precise identification of pathogens:reducing aquaculture losses to improve resource efficiency,promoting the transformation of aquaculture models to data-driven,ensuring the safety of aquatic products to enhance the competitiveness of the industry chain.The current technology has shortcomings such as lagging standardization,weak on-site anti-interference ability,and insufficient recognition of new pathogens.In the future,we need to focus on technological integration and innovation,intelligent upgrading,and standardization construction,promote technology from laboratories to industrial applications,and provide continuous support for the high-quality development of fisheries.
基金Penelitian Tesis Magister(PTM)Research Grant from Indonesian Government Kemdikbudristek with contract number 036/E5/PG.02.00.PL/2024.PPM1 2024 Research Grant from Faculty of Industrial Technology,ITB.
文摘The continuous increase in petroleum-based plastic food packaging has led to numerous environmental concerns.One effort to reduce the use of plastic packaging in food is through preservation using biopolymer-based packaging.Among the many types of biopolymers,chitosan is widely used and researched due to its non-toxic,antimicrobial,and antifungal properties.Chitosan is widely available since it is a compound extracted from seafood waste,especially shrimps and crabs.The biodegradability and biocompatibility of chitosan also showed good potential for various applications.These characteristics and propertiesmake chitosan an attractive biopolymer to be implemented as food packaging in films and coatings.Chitosan has been tested in maintaining and increasing the shelf life of food,especially seafood such as fish and shrimp,and post-harvest products such as fruits and vegetables.In addition to its various advantages,the properties and characteristics of chitosan need to be improved to produce optimal preservation.The properties and characteristics of chitosan are improved by adding various types of additive materials such as biopolymers,plant extracts,essential oils,and metal nanoparticles.Research shows that material additives and nanotechnology can improve the quality of chitosan-based food packaging for various types of food by enhancing mechanical properties,thermal stability,antimicrobial activity,and antioxidant activity.This review provides a perspective on the recent development and properties enhancement of chitosan composite with additives and nanotechnology,as well as this material’s challenges and prospects as food packaging.
基金supported by the National Key Research and Development Program of China(Grant No.2023YFB3710805).
文摘Ultra-high-strength aluminumalloy profile is an ideal choice for aerospace structuralmaterials due to its excellent specific strength and corrosion resistance.However,issues such as uneven metal flow,stress concentration,and forming defects are prone to occur during their extrusion.This study focuses on an Al-Zn-Mg-Cu ultra-high-strength aluminum alloy profile with a double-U,multi-cavity thin-walled structure.Firstly,hot compression experiments were conducted at temperatures of 350○C,400○C,and 450○C,with strain rates of 0.01 and 1.0 s^(−1),to investigate the plastic deformation behavior of the material.Subsequently,a 3D coupled thermo-mechanical extrusion simulation model was established using Deform-3D to systematically analyze the influence of die structure and process parameters on metal flow velocity,effective stress/strain,and temperature distribution.The simulation revealed significant velocity differences,stress concentration,and uneven temperature distribution.Key parameters,including mesh density,extrusion ratio,die fillet,and bearing length,were optimized through full-factorial experiments.This optimization,combined with a stepped flow-guiding die design,effectively improved the metal flow pattern during extrusion.Trial production based on both the initial and optimized parameters were carried out.A comparative analysis demonstrates that the optimized scheme results in a final profile whose cross-section matches the target design closely,with complete filling of complex features and no obvious forming defects.This research provides a valuable reference for the extrusion process optimization and die design of complex-section profiles made from ultra-high-strength aluminum alloys.
基金Supported by Shanghai Agriculture Applied Technology Development Program (Grant No.T20220120).
文摘[Objectives]This study was conducted to establish a quantitative assessment method for the textural quality of chieh-qua fruit.[Methods]Using two modes of a texture analyzer,namely TPA(texture profile analysis)and puncture,the index data of the fruit were obtained by setting different trigger forces,deformation levels,test speeds,as well as puncture speeds and puncture depths.The data included TPA hardness,adhesiveness,springiness,cohesiveness,gumminess,chewiness,resilience,as well as skin hardness,skin toughness,flesh hardness,fracturability,and compactness.[Results]Different deformation levels had a significant impact on all parameters.Hardness,adhesiveness,gumminess and chewiness showed a trend of first increasing and then decreasing with the deformation level increasing.When the deformation level was 30%,the adhesiveness,gumminess and chewiness reached their maximum values.When the deformation level was 50%,TPA hardness reached its maximum.When the compression speed was 3 mm/s,the measured values of TPA hardness,adhesiveness,chewiness,and resilience were at their maximums.The skin hardness varied significantly under different trigger forces.When the trigger force was 15 g,the skin hardness reached a maximum value of 944.63 g,and the skin toughness,flesh hardness,fracturability,and compactness also reach their maximum values respectively.When the puncture depth was 12 mm,the flesh hardness and skin toughness reached their maximums of 682.51 g and 1.82 mm,respectively.In the TPA mode,the flesh hardness of chieh-qua showed an extremely significant negative correlation with springiness,cohesiveness,and resilience(P<0.01).The fruit fracturability detected by puncture had an extremely significant positive correlation with compactness(P<0.01).[Conclusions]The evaluation method for measuring chieh-qua texture by combining TPA and the puncture mode could accurately and quantitatively reflect the differences in the flesh texture quality of chieh-qua.The optimal parameters for texture measurement of chieh-qua fruit were determined as a 15 g trigger force with 50%deformation and a 3 mm/s compression speed in TPA mode,and a 15 g trigger force with a 12 mm puncture depth in puncture mode.Puncture speed was found to have no significant effect on the texture indices of chieh-qua.
文摘One of the main issues in designing optimum tapered cascades for uranium enrichment for annual fuel production in a power reactor is whether to employ large(fat)or small(thin)cascades.What will be the permissible and optimal ranges of the number of machines that can be used in a cascade?For the first time,the permissible and optimal ranges of the number of gas centrifuges that can be utilized in a cascade were investigated using two types of centrifuges,and the performance of small and large tapered cascades was discussed.The particle swarm optimization algorithm(PSO)has been used to optimize tapered cascades.The results show:(1)For the first centrifuge,41 cascades(91≤n≤4897)and for the second centrifuge,49 cascades(18≤n≤3839)with small and large sizes can be used in enrichment facilities,and the best cascade for them has 530(with 23 stages)and 39(with 7 stages)centrifuges,respectively.(2)For both centrifuges,when 600≤n(number of centrifuges=n),the large cascade performance changes are relatively insignificant.(3)For both types of gas centrifuges,the annual los s of separation power in enrichment facilities is approximately 1.25%-4.82%of the total separation work required.
文摘Subcritical reactors(SCRs)or subcritical assemblies(SCAs)are the main infrastructure for designing power reactors.These reactors are widely used for training and research because of their high level of inherent safety.The objective of this study is to design a subcritical reactor using a pressurized water reactor(PWR)conventional fuel following two safety points.In the first approach,deeply placed SCR cores with an infinite multiplication factor(k_(∞))of less than unity were identified using the DRAGON lattice code.In the second approach,subcritical reactor cores with an effective multiplication factor(k_(eff))of less than unity were determined by coupling the cell calculations of the DRAGON lattice code and core calculations of the DONJON code.For the deeply subcritical reactor design,it was found that the reactor would remain inherently subcritical while using fuel rods with ^(235)U enrichment of up to 0.9%,regardless of the pitch of the fuel rods.In the second approach,the optimal pitches(1.3 to 2.3 cm)were determined for different fuel enrichment values from 1 to 5%.Subsequently,the k_(eff) was obtained for a fuel rod arrangement of 8×8 to 80×80,and the states in which the reactor would be subcritical were determined for different fuel enrichments at the corresponding optimal pitch.To validate the models used in the DRAGON and DONJON codes,the k_(eff) of the Isfahan Light Water Subcritical Reactor(LWSCR)was experimentally measured and compared with the results of the calculations.Finally,the effects of fuel and moderator temperature changes were investigated to ensure that the designed assemblies remained in the subcritical state at all operational temperatures.
基金supported by the Key Research and Development Program of Shaanxi Province(2023-GHZD-33)the Open Project of the State Key Laboratory of Intelligent Game(ZBKF-23-05)the National Nature Science Foundation of China(62003267)。
文摘To address the issue of incorrect fusion results caused by conflicting evidence due to inaccurate evidence and incomplete recognition frameworks in radar airborne target tactical intention recognition,a spatiotemporal evidence fusion algorithm is proposed.To resolve the conflict evidence fusion problem caused by inaccurate evidence,the algorithm performs discounting of evidence from both spatial and temporal dimensions.Spatial discounting is influenced by both inter-evidence inconsistency and intra-evidence inconsistency,while temporal discounting is determined by time intervals and information entropy.For the problem of conflicting evidence fusion due to an incomplete recognition framework,an open recognition architecture based on dynamic composite focal elements is proposed.This approach allocates some conflicting information to temporary composite focal elements,avoiding excessive basic probability assignment(BPA)of the empty set after fusion,which can lead to deviations from the actual fusion results.Simulation experiments comparing various methods indicate that the proposed method can effectively improve target intention recognition accuracy and demonstrates good stability.
基金supported by the Guangdong Basic and Applied Basic Research Foundation,China(No.2021B1515140007).
文摘The Southern Advanced Photon Source(SAPS)is a diffraction-limited synchrotron light source under design,which employs longitudinal injection as its primary injection scheme.This kind of injection scheme requires that the injected beam has a short bunch length and low emittance,and the preferred injector should offer high stability and low cost.Therefore,an injector based on a booster synchrotron was developed.The proposed injector includes a 250 MeV linac,a booster synchrotron that ramps the beam energy to 3.5 GeV,and two beam transport lines to ensure efficient beam delivery and beam quality preservation.The linac utilizes a thermionic high-voltage DC gun for reliable operation and features a bunching system with an advanced focusing system to preserve the emittance.To meet the injection requirements of the SAPS,a comprehensive design for the booster has been conducted.The booster synchrotron employs a threefold lattice structure,incorporating modified theoretical minimum emittance cells with a small momentum compaction factor and a high voltage to achieve an emittance of 3.98 nm rad and a bunch length of 4.8 mm.The injector has the potential to deliver a high charge,reducing the injection period of the storage ring to less than 1 min.Simulations demonstrated the expected performance,with a transmission efficiency of 90%,confirming its capability to meet the injection requirement of the SAPS storage ring.This design offers a stable and efficient solution for the SAPS.
基金supported by Research and Innovation Foundation of Wuhan Asia General Hospital,No.2022KYCX1-B10(to FH)the Natural ScienceFoundation of Hubei Province,No.2023AFB550(to FH)+2 种基金the National Natural Science Foundation of China,Nos.32400554(to FH),82371444(to YZ)theGuiding Project of the Scientific Research Program of the Department of Education of Hubei Province,No.B2021016(to FH)the Natural Science Foundationof Hubei Province,No.2024AFB853(to QW).
文摘Alzheimer’s disease-associated transcriptomic landscapes have been defined in brain tissue.However,changes in blood RNA and their clinical relevance remain poorly understood.In this study,we developed an RNA profile based on 1468 blood samples from both human and mouse studies,which include bulk RNA sequencing(RNA-seq),microRNA-seq,and single-cell RNA-seq data.We developed a comprehensive analysis pipeline that conducted over 11 million comparisons and correlations to identify more than 20,000 blood features.With these findings,we established a blood RNA database related to Alzheimer’s disease,RNAs in Blood of AD(RBAD,http://www.bioinform.cn/RBAD/).Using RBAD,we initially validated well-established Alzheimer’s disease-related pathways,including olfactory transduction.We then observed a decrease in both the proportion and functionality of erythroid cells,likely attributed to their elevated CD45 levels and interactions with GZMK^(+)CD8^(+)T cells.Furthermore,we identified 449 blood RNAs linked to patients’overall survival,along with two mRNAs(H4C3 and CTU1)associated with cognitive decline.In summary,RBAD is the first web-based analysis platform dedicated to investigating blood RNA changes in Alzheimer’s disease,and provides valuable insights into potential peripheral biomarkers and pathogenic mechanisms related to Alzheimer’s disease.
文摘To ensure the safe transportation of radioactive materials,numerous countries have established specific standards.For the transfer of fissile materials,it is imperative that the material within the packaging remains in a subcritical state during routine,normal,and accidental transport conditions.In the event of an accident,the rods within the storage tank may become rearranged,introducing uncertainty that must be accounted for to ensure that criticality analysis results are conservative.Historically,this uncertainty was addressed overly conservatively due to limited research on non-uniform arrangement scenarios,which proved unsuitable for criticality safety analysis of spent fuel packages.This paper introduced three distinct methods to non-uniformly rearrange fuel rods—Uniform Arrangement by Blocks,Layer-by-Layer Determination,and Birdcage Deformation—and meticulously evaluates the influences of rod rearrangement on the effective multiplication factor of neutrons,k eff,utilizing the Monte Carlo method.Ultimately,this study presents a holistic method capable of encompassing the entire spectrum of potential effects stemming from the rearrangement of fuel rods during rods mispositioning accident.By augmenting the safety margin,this approach proves to be adeptly suited for the criticality safety analysis of nuclear fuel transport containers.
基金Natural Science Foundation of Beijing Municipality under Grant L243004the National Natural Science Foundation of China under Grant 62403060.
文摘Protective hardware is essential for mitigating damage caused by unavoidable falls in humanoid robots.Despite notable progress in fall protection hardware,the theoretical foundation for modeling and the feasibility of conducting full-scale fall experiments on robots or their surrogates remain somewhat limited.This paper proposes a method for optimizing the thickness of Expandable Polyethylene(EPE),which is used as back protection for the Chubao humanoid robot,based on small-scale impact test data to predict full-scale behavior.The optimal thickness is defined as a balance between compact design and protective effectiveness.An equivalent impact model characterized by four parameters:contact area S,mass m,fall height h,and cushioning material thickness d is introduced to describe impact conditions.The relationship between the peak impact acceleration ap and material thickness d,which forms the core of the method and gives rise to the name AP-D,is analyzed through their plotted curves.After introducing three characteristic parameters and two correction fac-tors,the relationship among the aforementioned variables is derived.Subsequently,both the optimal thickness do and its corresponding peak impact acceleration aop are predicted via nonlinear and linear regression models.Finally,the accuracy and effectiveness of the theoretically derived optimal thickness are validated on both a dummy and the actual robot.With the cushioning material applied,the peak chest acceleration is reduced to 41.57g for the dummy and 32.08g for the robot.
基金financially supported by the National Key R&D Program of China(2022YFA1304103)Agricultural Scientific and Technological Innovation Project of Shandong Academy of Agricultural Sciences(CXGC2024A04)SKLMT Frontiers&Challenges Project.
文摘Beer is a prominent fermented food product and is regarded as the one of most widely consumed beverage globally.There is a dearth of studies examining the impact of different types of beer with intricate components as a comprehensive intervention on human health and immune status.This study used a 14-day continuous drinking intervention consisting of 5 beers,namely white beer,India pale ale(IPA),Pilsner,non-alcoholic beer,and premium lager beer.Surprisingly,our findings indicate that consuming white beer has little impact on the gut microbiota and physiological condition of mice,whereas consuming other types of beer leads to an increase in Lactobacillus and a decrease in Lachnospiraceae.In addition,we devised an extended feeding experiment to investigate the comparative safety and health benefits of consuming white beer.The research showed that when mice drank excessive quantities of white beer over 42 days,the intestines of the mice had more Prevotellaceae and the Firmicutes to Bacteroidetes ratio(F/B ratio)had a decline from 1.29 to 0.38.The levels of acetic acid,propionic acid,and isobutyric acid increased from 1.0,0.27,and 0.015 mg/g to 1.28,0.38,and 0.037 mg/g,respectively(P<0.05).There were no significant changes observed in the levels of most measured cytokines in the colon tissue of mice that consumed beer,however,there was an increase in the concentration of the inflammatory factor tumor nesrosis factor-α(TNF-α)from 135.86 pg/mL in the control group to 189.78 pg/mL in the white beer group(P<0.01).These results give us real-world proof that we can use to study how different beers affect the host’s health and satisfaction in future research.
基金funded by the National Key Research and Development Program of China(Grant No.2022YFB3608602)the National Natural Science Foundation of China(Grant Nos.62404215 and 62574199)Instrument and Equipment Development Project of CAS(Grant No.PTYQ2024TD0003)。
文摘The synthesis of high-quality heteroepitaxial diamond films on iridium composite substrates is a critical step toward advancing diamond for electronic and optical applications.Microwave plasma chemical vapor deposition,combined with in situ optical emission spectroscopy,enables precise control over growth modes through plasma parameter tuning.In this study,we examine how methane concentration,microwave power,and gas pressure influence plasma species and,consequently,the growth modes of heteroepitaxial diamond by optical emission spectroscopy and scanning electron microscope.At low nucleation densities,increased methane concentrations promote the transition from faceted polyhedral to ballas structures,driven by elevated C_(2) radical concentrations in the plasma.Conversely,at higher nucleation densities,gas pressure,and substrate temperature dominate growth mode determination,leading to diverse morphologies,such as planar,polycrystalline,octahedral,and step-flow growth.These findings elucidate the interplay among plasma species,growth parameters,and growth mode,offering critical insights for optimizing growth conditions and preparing heteroepitaxial diamond films in a specific growth mode.
基金supported by the Belle Carnell Regenerative Neurorehabilitation Fundthe National Institutes of Health(R01NS113935 to CKF)。
文摘Human spinal cord organoids(hSCOs)offer a promising platform to study neurotrauma by addressing many limitations of traditional research models.These organoids provide access to human-specific physiological and genetic mechanisms and can be derived from an individual's somatic cells(e.g.,blood or skin).This enables patient-specific paradigms for precision neurotrauma research,pa rticula rly relevant to the over 300,000 people in the United States living with chronic effects of spinal cord injury(SCI).
