The treatment of POME related contamination is complicated due to its high organic contents and complex composition.Membrane technology is a prominent method for removing POME contaminants on account of its efficiency...The treatment of POME related contamination is complicated due to its high organic contents and complex composition.Membrane technology is a prominent method for removing POME contaminants on account of its efficiency in removing suspended particles,organic substances,and contaminants from wastewater,leading to the production of high-quality treated effluent.It is crucial to achieve efficient POME treatment with minimum fouling through membrane advancement to ensure the sustainability for large-scale applications.This article comprehensively analyses the latest advancements in membrane technology for the treatment of POME.A wide range of membrane types including forward osmosis,microfiltration,ultrafiltration,nanofiltration,reverse osmosis,membrane bioreactor,photocatalytic membrane reactor,and their combinations is discussed in terms of the innovative design,treatment efficiencies and antifouling properties.The strategies for antifouling membranes such as self-healing and self-cleaning membranes are discussed.In addition to discussing the obstacles that impede the broad implementation of novel membrane tech nologies in POME treatment,the article concludes by delineating potential avenues for future research and policy considerations.The understanding and insights are expected to enhance the application ofmembrane-basedmethods in order to treat POME more efficiently;this will be instrumental in the reduction of environmental pollution.展开更多
On July 2^(nd),2025,32 scientists representing 15 countries gathered at Tartu,Estonia to make on-site endorsements for the Global ONCE(Ocean Negative Carbon Emissions)Program at the 12th INTECOL Wetlands Conference.Th...On July 2^(nd),2025,32 scientists representing 15 countries gathered at Tartu,Estonia to make on-site endorsements for the Global ONCE(Ocean Negative Carbon Emissions)Program at the 12th INTECOL Wetlands Conference.This marks a significant milestone for ONCE in establishing a systematic framework for coastal wetland carbon sequestration research and global collaboration(Figs.1,2).Coastal wetlands are critical transition zones linking terrestrial and marine ecosystems,yet they face severe degradation from anthropogenic land-based activities and sea level rise that propagate impacts to the ocean.As a UN Ocean Decade Program,the Global ONCE Program champions interdisciplinary and cross-regional collaboration to enhance carbon sequestration in the ocean and coastal wetlands through science and innovation.Aligned with the Tartu Declaration on Wetlands that includes resolutions to promote the rights of global wetlands(especially peatlands)and advance the discipline of wetland science based on facts,this initiative addresses key knowledge gaps in land-ocean interactions.The goal is to harness the full potential of coastal wetlands and ocean systems for climate mitigation,thereby laying a scientific foundation for international policy formulation and implementation.展开更多
Caffeic acid-O-methyltransferase(COMT)is a crucial enzyme in the phenylpropanoid metabolic pathway,with significant roles in both the lignin and coumarin pathways.The function of COMT in plant disease resistance has b...Caffeic acid-O-methyltransferase(COMT)is a crucial enzyme in the phenylpropanoid metabolic pathway,with significant roles in both the lignin and coumarin pathways.The function of COMT in plant disease resistance has been demonstrated in several species.Our research identified the potato COMT gene family on a genome-wide scale and StCOMT1 as a candidate gene for enhancing potato disease resistance under DON induction through phylogenetic analyses combined with previously identified metabolic differences and weighted gene co-expression network analysis(WGCNA)results.In order to better understand the function of StCOMT1,heterologous expression and overexpression assays were conducted.StCOMT1 is localized in chloroplasts and was found to catalyze the methylation of substrates to produce ferulic acid and melatonin in vitro.Physiological parameters showed that,compared with wild-type potato plants,StCOMT1-overexpressing plants infected with Fusarium sporotrichioides exhibited smaller lesion areas and lower reactive oxygen species(ROS)levels.High-performance liquid chromatography(HPLC)and RT-qPCR analyses revealed organ-specific accumulation of coumarin-related compounds and organ-specific expression of their corresponding genes in StCOMT1-overexpressing plants post-inoculation.The results indicate that StCOMT1 overexpression in potatoes enhanced resistance to F.sporotrichioides by enhancing reactive oxygen species clearance and promoting organ-specific accumulation of coumarin-related compounds.展开更多
A large-scale view of the magnetospheric cusp is expected to be obtained by the Soft X-ray Imager(SXI)onboard the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE).However,it is challenging to trace the three-d...A large-scale view of the magnetospheric cusp is expected to be obtained by the Soft X-ray Imager(SXI)onboard the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE).However,it is challenging to trace the three-dimensional cusp boundary from a two-dimensional X-ray image because the detected X-ray signals will be integrated along the line of sight.In this work,a global magnetohydrodynamic code was used to simulate the X-ray images and photon count images,assuming an interplanetary magnetic field with a pure Bz component.The assumption of an elliptic cusp boundary at a given altitude was used to trace the equatorward and poleward boundaries of the cusp from a simulated X-ray image.The average discrepancy was less than 0.1 RE.To reduce the influence of instrument effects and cosmic X-ray backgrounds,image denoising was considered before applying the method above to SXI photon count images.The cusp boundaries were reasonably reconstructed from the noisy X-ray image.展开更多
Bayan Obo rare earth mine is the largest light rare earth resource worldwide,primarily extracts rare earth elements(REEs)from mixed RE concentrates with bastnaesite and monazite.Nevertheless,the adoption of the concen...Bayan Obo rare earth mine is the largest light rare earth resource worldwide,primarily extracts rare earth elements(REEs)from mixed RE concentrates with bastnaesite and monazite.Nevertheless,the adoption of the concentrated sulfuric acid roasting metallurgical process has resulted in damage to the environment.Therefore,this paper adopted the method of selective mineral phase transformation(MPT)followed by enhanced micro-flotation.By determining the optimal MPT co nditions,the flotation recovery of bastnaesite-roasted products by the collector(phthalic acid,PA)is improved,and the enhanced separation of bastnaesite with monazite is realized.The results show that with the increase of roasting temperature and time,the bastnaesite decomposition product is CeOF and monazite does not change significantly.Subsequent micro-flotation exhibits a gradual decline in the PA consumption of bastnaesiteroasted products,while the flotation recovery of monazite-roasted products remains poor.The artificial mixed ore experiments result in a CeOF foam product with a content of 94.14%and a recovery of 85.80%,and a monazite tank product with a content of 73.53%and a recovery of 87.87%.Compared with the preroasting ore,the surface and interior of bastnaesite-roasted products develop numerous cracks and porosities,and no obvious structural damage is observed in monazite-roasted particles.As the roasting temperature increases,the mineral particles undergo recrystallization or closure,reducing the specific surface area of bastnaesite-roasted products and enhancing hydrophobicity,leading to diminished PA consumption.Fourier transform infrared and other flotation-relation tests show that PA is chemisorbed on the surface of CeOF.The MPT conditions are optimized in this study,which provides a reference for further advancing the efficient separation of bastnaesite and monazite.展开更多
In order to address the evolving emission characteristics of oxygenated volatile organic compounds(OVOCs),it is essential to develop adsorbent materials specifically designed for the efficient adsorption of OVOCs with...In order to address the evolving emission characteristics of oxygenated volatile organic compounds(OVOCs),it is essential to develop adsorbent materials specifically designed for the efficient adsorption of OVOCs with large kinetic diameters.In this study,we used co-pyrolysis to prepare a series of graded porous carbon materials with well-developed micropores by adjusting the doping ratios of root nodules and pretreated cellulose.The material with root nodule to cellulose mass ratio of 1:1(TCC-RN-1)exhibited the highest saturated adsorption capacity for butyl acetate(834 mg/g).This can be attributed to enhanced pore size distribution from nodule doping,which facilitates the development of a micropore-graded structure.Additionally,the nodules acted as auxiliary activating agents that enhanced the KOH micropore regulation effect during the activation stage,resulting in the highest micropore volume(0.863 cm^(3)/g).The doping of root nodules facilitated the formation of additional defects on the surface of the porous carbon material,leading to a more disordered arrangement that improved pollutant adsorption.Furthermore,TCC-RN-1 demonstrated good thermal stability in an air atmosphere,main-taining a butyl acetate adsorption capacity exceeding 95%after five adsorption-desorption cycles.This indicates its favorable potential for industrial applications.展开更多
Additive manufacturing(AM),with its high flexibility,cost-effectiveness,and customization,significantly accelerates the advancement of nanogenerators,contributing to sustainable energy solutions and the Internet of Th...Additive manufacturing(AM),with its high flexibility,cost-effectiveness,and customization,significantly accelerates the advancement of nanogenerators,contributing to sustainable energy solutions and the Internet of Things.In this review,an in-depth analysis of AM for piezoelectric and triboelectric nanogenerators is presented from the perspectives of fundamental mechanisms,recent advancements,and future prospects.It highlights AM-enabled advantages of versatility across materials,structural topology optimization,microstructure design,and integrated printing,which enhance critical performance indicators of nanogenerators,such as surface charge density and piezoelectric constant,thereby improving device performance compared to conventional fabrication.Common AM techniques for nanogenerators,including fused deposition modeling,direct ink writing,stereolithography,and digital light processing,are systematically examined in terms of their working principles,improved metrics(output voltage/current,power density),theoretical explanation,and application scopes.Hierarchical relationships connecting AM technologies with performance optimization and applications of nanogenerators are elucidated,providing a solid foundation for advancements in energy harvesting,self-powered sensors,wearable devices,and human-machine interaction.Furthermore,the challenges related to fabrication quality,cross-scale manufacturing,processing efficiency,and industrial deployment are critically discussed.Finally,the future prospects of AM for nanogenerators are explored,aiming to foster continuous progress and innovation in this field.展开更多
Large-scale CO_(2)emissions have exacerbated the greenhouse effect,reinforcing the critical need for efficient CO_(2)mitigation methods.Plasma-catalytic technology enables CO_(2)conversion under mild conditions,especi...Large-scale CO_(2)emissions have exacerbated the greenhouse effect,reinforcing the critical need for efficient CO_(2)mitigation methods.Plasma-catalytic technology enables CO_(2)conversion under mild conditions,especially for CO_(2)methanation(the Sabatier reaction),which has attracted significant attention due to its economic benefits and the potential for safe energy transportation via existing natural gas pipelines.The development of high-performance CO_(2)methanation catalysts remains an ongoing and long-term objective,and there is a lack of adequate in-situ characterization techniques to investigate the mechanisms.This study focuses on the Ni/La_(2)O_(3)(LN)catalyst and introduces two CO_(2)activation strategies through F and Na modifications:the Ni-Ov-Ni site activation with electron transfer from Ni0 under low-power conditions and basic site activation under high-power conditions.The LN-NaF catalysts enhance CO_(2)methanation activity across the entire power range compared to LN,achieving a CO_(2)conversion of 86.3%and CH4 selectivity of 99.4%.Additionally,LN-F(h)reaches a CH4 yield 4.15 times higher than that of LN at low power.Furthermore,in-situ diffuse reflectance infrared Fourier transform(DRIFT)spectroscopy with a self-made reactor are performed under plasma-catalytic conditions to reveal the CO_(2)adsorption and conversion mechanisms,indicating that different dopants(F,Na,and NaF)exhibit promoting effects on different intermediates,resulting in variations in CO_(2)methanation activity.This study provides valuable insights for improving catalyst performance and a thorough comprehension of mechanisms in CO_(2)methanation.展开更多
Background and purpose: Lifelong endurance exercise is generally associated with cardiovascular health benefits.However, recent studies suggest that prolonged high-volume training may contribute to coronary atheroscle...Background and purpose: Lifelong endurance exercise is generally associated with cardiovascular health benefits.However, recent studies suggest that prolonged high-volume training may contribute to coronary atherosclerosis,even in athletes with low traditional cardiovascular risk. This case report aims to explore the cardiovascular status of a master endurance athlete with an exceptionally high lifetime training volume, in light of recent concerns raised in the literature.Methods: We present the case of a 60-year-old recreational male marathon runner with no history of cardiovascular disease, who completed over 500 marathons between the ages of 30 and 60 years, covering ~127 000-km running. In 2024 alone, he completed 60 marathons. Cardiovascular evaluation included clinical risk assessment and coronary computed tomography angiography(CTCA).Results: The runner was asymptomatic, had a low ESC-SCORE2(3.3%), a favorable lipid profile, and normal levels of high-sensitivity C-reactive protein and lipoprotein(a). CTCA revealed no evidence of calcified, mixed, or non-calcified coronary plaques.Conclusions: This case highlights that some master athletes may demonstrate resilience to coronary atherosclerosis despite decades of high training volume. In low-risk individuals, prolonged endurance training alone may not necessarily lead to coronary artery disease, emphasizing the need for individualized cardiovascular screening strategies.展开更多
Objective To report the first Bahrain national registry for ART treatments initiated from January 1, 2000 to December 31, 2005. Methods The ＂World Report on ART＂ forms, prepared by the International Committee for M...Objective To report the first Bahrain national registry for ART treatments initiated from January 1, 2000 to December 31, 2005. Methods The ＂World Report on ART＂ forms, prepared by the International Committee for Monitoring Assisted Reproductive Technology （ICMART）, were filled from database records of all procedures and their respective outcome carried out at Banoon ART Centre, the Military Hospital, Bahrain during the period of 2000-2006. Results A total of 1490 completed cycles were performed. ICSI constituted 42.68% （636）, IVF constituted 35.50% （529）, while frozen-thawed embryo replacement cycles represented only 21.18% （325） of all ART cycles. The clinical pregnancy rates per transfer for IVF and ICSI cycles were 26.65% and 21.70%, respectively. The distribution of singleton, twin and triplet deliveries for IVF,, ICSI and FET combined were 80. 0%, 16.3% and 3.7%, respectively. The average delivery rate per clinical pregnancy for fresh and frozen cycles was 57.3%. As a result of ART services, 266 neonates were born. Complications of ART were solely due to ovarian hyperstimulation syndrome （OHSS） which constituted 2.26% of all aspirated cycles. Conclusion Multiple pregnancy rate was high due to transferring 〉3 embryos. Pregnancy loss and OHSS were relatively high thus preventative measures were recommended. This report paves the way for the other IVF centers in Bahrain to provide their own data for the national ART registry.展开更多
Simultaneous localization and mapping(SLAM)is one of the most attractive research hotspots in the field of robotics,and it is also a prerequisite for the autonomous navigation of robots.It can significantly improve th...Simultaneous localization and mapping(SLAM)is one of the most attractive research hotspots in the field of robotics,and it is also a prerequisite for the autonomous navigation of robots.It can significantly improve the autonomous navigation ability of mobile robots and their adaptability to different application environments and contribute to the realization of real-time obstacle avoidance and dynamic path planning.Moreover,the application of SLAM technology has expanded from industrial production,intelligent transportation,special operations and other fields to agricultural environments,such as autonomous navigation,independent weeding,three-dimen-sional(3D)mapping,and independent harvesting.This paper mainly introduces the principle,sys-tem framework,latest development and application of SLAM technology,especially in agricultural environments.Firstly,the system framework and theory of the SLAM algorithm are introduced,and the SLAM algorithm is described in detail according to different sensor types.Then,the devel-opment and application of SLAM in the agricultural environment are summarized from two aspects:environment map construction,and localization and navigation of agricultural robots.Finally,the challenges and future research directions of SLAM in the agricultural environment are discussed.展开更多
Objective:The main objective of this project was to studyhow to secure the wandering of elderly persons diagnosed with dementia caused by Alzheimer’s disease by using healthcare technologies. Methods:The study was ca...Objective:The main objective of this project was to studyhow to secure the wandering of elderly persons diagnosed with dementia caused by Alzheimer’s disease by using healthcare technologies. Methods:The study was carried out during a three-year period (2008-2011) in the region of South Ostrobothnia, Finland. Thirty-two elderly persons living at home and diagnosed with Alzheimer’s disease participated in the study. The ages of the intervention group ranged from 66 to 90 years;the average age was 81 years. A total of 63 different home care devices including 24 location based technologies were tested during the intervention.The choice of technology used was based on the individual needs of the elderly person. Results:Participants with mild stage memory impairment were able to use and benefit from the technology installed during the intervention to live more independently.The most useful devices were those that operated within the home. Nine of ten users of door alarm systems, five of nine users of GPS systems and all users of GSM systems were satisfied with the technologies. Conclusions:Location based alarm and access control technology can have a positive impact on the lives of elderly persons suffering from dementia. When chosen appropriately, technology can help to reduce or eliminate the wandering often associated with dementia.Regardless of the technology used, it should be installed when the elderly person is at the early stages of dementia;at later stages of the disease it is usually impossible for the elderly to adequately adopt the device.展开更多
Wireless millirobots engineered to infiltrate intricate vascular networks within living organisms,particularly within constricted and confined spaces,hold immense promise for the future of medical treatments.However,w...Wireless millirobots engineered to infiltrate intricate vascular networks within living organisms,particularly within constricted and confined spaces,hold immense promise for the future of medical treatments.However,with their multifaceted and intricate designs,some robots often grapple with motion and functionality issues when confronted with tight spaces characterized by small cross-sectional dimensions.In this study,drawing inspiration from the high aspect ratio and undulating swimming patterns of snakes,a millimeter-scale,snake-like robot was designed and fabricated via a combination of extrusion-based four-dimensional(4D)printing and magnetic-responsive intelligent functional inks.A sophisticated motion control strategy was also developed,which enables the robots to perform various dynamic movements,such as undulating swimming,precise turns,graceful circular motions,and coordinated cluster movements,under diverse magnetic field variations.As a potential application,the snake robot can navigate and release drugs in a model coronary intervention vessel with tortuous channels and fluid filling.The novel design and promising applications of this snake robot are invaluable tools in future medical surgeries and interventions.展开更多
Ouricuri endocarp was utilized as a biosorbent for the recovery of europium(Eu(Ⅲ))from aqueous solutions and rare earth elements(REEs)from authentic leachate derived from phosphogypsum,which encompasses various REEs....Ouricuri endocarp was utilized as a biosorbent for the recovery of europium(Eu(Ⅲ))from aqueous solutions and rare earth elements(REEs)from authentic leachate derived from phosphogypsum,which encompasses various REEs.Various characterization techniques were applied to analyze the physicochemical and adsorptive properties of the biosorbent.The results indicate that the adsorption kinetic data conform well to the pseudo-first-order model,while the Liu model describes the equilibrium data well.Ouricuri endocarp and Eu interactions are favorable and spontaneous.The maximum adsorption capacity for Eu(Ⅲ)is determined to be 22.9 mg/g according to the Liu model.Based on experimental results and adsorbent characteristics,the proposed adsorption mechanisms between ouricuri endocarp and Eu include ion exchange and electrostatic interactions as the primary mechanisms.The Eu(Ⅲ)recovery is also feasible as a continuous flow process demonstrating inclined breakthrough curves and lower values of the length of the mass transfer zone.Ouricuri endocarp demonstrates its selectivity for recovering various REEs from authentic phosphogypsum leachate.It achieves a 98%recovery rate for Eu and approximately 60%for Ce,La,and Nd,affirming its efficacy under real-world conditions.Finally,concentration of REE was done by ashing loaded ouricuri endocarp,and a solid with around 34%(in weight)of REE is obtained.展开更多
Mixed matrix membranes(MMMs)have demonstrated significant promise in energy-intensive gas separations by amalgamating the unique properties of fillers with the facile processability of polymers.However,achieving a sim...Mixed matrix membranes(MMMs)have demonstrated significant promise in energy-intensive gas separations by amalgamating the unique properties of fillers with the facile processability of polymers.However,achieving a simultaneous enhancement of permeability and selectivity remains a formidable challenge,due to the difficulty of achieving an optimal match between polymers and fillers.In this study,we incorporate a porous carbon-based zinc oxide composite(C@ZnO)into high-permeability polymers of intrinsic microporosity(PIMs)to fabricate MMMs.The dipole–dipole interaction between C@ZnO and PIMs ensures their exceptional compatibility,mitigating the formation of non-selective voids in the resulting MMMs.Concurrently,C@ZnO with abundant interconnected pores can provide additional low-resistance pathways for gas transport in MMMs.As a result,the CO_(2) permeability of the optimized C@ZnO/PIM-1 MMMs is elevated to 13,215 barrer,while the CO_(2)/N_(2) and CO_(2)/CH_(4) selectivity reached 21.5 and 14.4,respectively,substantially surpassing the 2008 Robeson upper bound.Additionally,molecular simulation results further corroborate that the augmented membrane gas selectivity is attributed to the superior CO_(2) affinity of C@ZnO.In summary,we believe that this work not only expands the application of MMMs for gas separation but also heralds a paradigm shift in the application of porous carbon materials.展开更多
In this study,to better decide the effect of coal seam dip angle upon the dynamic change of the crossfusion in gas transport and storage areas during the progress of working face in the high gas thick coal seam,a two-...In this study,to better decide the effect of coal seam dip angle upon the dynamic change of the crossfusion in gas transport and storage areas during the progress of working face in the high gas thick coal seam,a two-dimensional physical simulation experiment regarded as the theoretical research was conducted to properly explore the variation law of overburden fracture.The results demonstrated that the boundary of the gas transport zone was located in the region of fracture separation.The boundary of the gas storage area was located in the abrupt penetration zone.Also,according to the information theory,the state of the gas transport and storage areas was determined by the changing trend of the fracture rate and fracture entropy.The mathematical representation model of the dip effect in gas transport and storage areas was established.The criteria upon which the regional location of the gas transport area and gas storage area can be based were put forward.The cross-fusion evolution process of the dip effect in gas transport and storage areas was revealed as well.The research results could provide guidance for realising directional and accurate gas extraction.展开更多
Myeloblastosis(MYB)transcription factors,particularly those in the R2R3 MYB subclass,are pivotal in plant growth,development,and environmental stress responses.As one of the largest transcription factor families in pl...Myeloblastosis(MYB)transcription factors,particularly those in the R2R3 MYB subclass,are pivotal in plant growth,development,and environmental stress responses.As one of the largest transcription factor families in plants,the MYB family significantly regulates plant secondary metabolism,including the biosynthetic pathways for phenylpropanoids,which are crucial for stress resistance.This review presents a comprehensive overview of MYB transcription factor classification and their regulatory mechanisms in plant metabolism and stress responses.We discuss the roles of MYB transcription factors in biotic stress resistance,such as defense against pathogens and pests,and in abiotic stress tolerance,including responses to drought and salinity.Special attention is given to the interactions of R2R3 MYB with other transcription factors and co-repressors,focusing on how these synergistic or antagonistic relationships modulate physiological processes.The multifunctional role of R2R3 MYBs in stress responses positions them as promising targets for enhancing crop resilience through genetic breeding.Furthermore,this review highlights potential applications of MYB transcription factors in developing stress-resistant crops and their utility in plant resistant breeding programs.展开更多
In the current transformative era of biomedicine,hydrogels have established their presence in biomaterials due to their superior biocompatibility,tuneability and resemblance with native tissue.However,hydrogels typica...In the current transformative era of biomedicine,hydrogels have established their presence in biomaterials due to their superior biocompatibility,tuneability and resemblance with native tissue.However,hydrogels typically exhibit poor conductivity due to their hydrophilic polymer structure.Electrical conductivity provides an important enhancement to the properties of hydrogel-based systems in various biomedical applications such as drug delivery and tissue engineering.Consequently,researchers are developing combinatorial strategies to develop electrically responsive“SMART”systems to improve the therapeutic efficacy of biomolecules.Electrically conductive hydrogels have been explored for various drug delivery applications,enabling higher loading of therapeutic cargo with on-demand delivery.This review emphasizes the properties,mechanisms,fabrication techniques and recent advancements of electrically responsive“SMART”systems aiding on-site drug delivery applications.Additionally,it covers prospects for the successful translation of these systems into clinical research.展开更多
Selecting the embryo with the highest implantation potential is a top priority in in-vitro fertilization(IVF)centers.Few studies have explored the relationship between day 5 blastocyst morphokinetics and implantation ...Selecting the embryo with the highest implantation potential is a top priority in in-vitro fertilization(IVF)centers.Few studies have explored the relationship between day 5 blastocyst morphokinetics and implantation outcomes[1].Despite numerous time-lapse studies,the findings often conflict due to differences in patient demographics,lab conditions,and protocols,such as oxygen concentration[2].Thus,there is ongoing debate regarding which parameters are most predictive of implantation.展开更多
Diabetes is a growing global health concern,calling for improved diagnostic and therapeutic strategies.Of the emerging possible biomarkers,microRNA 375(miR-375)has gained attention for its pivotal role in pancreaticβ...Diabetes is a growing global health concern,calling for improved diagnostic and therapeutic strategies.Of the emerging possible biomarkers,microRNA 375(miR-375)has gained attention for its pivotal role in pancreaticβcell development and function,and its altered blood levels followingβcell injury.This review summarizes the current knowledge on the role of miR-375 in insulin regulation,its correlation with diabetes,and its clinical potential.Despite its well-known role inβcell biology,literature analyses have failed to reveal a consistent correlation between the circulating levels of miR-375 and diabetes.A key limitation lies in the lack ofβcell specificity of miR-375,along with its modulation by diabetes-related complications,which influences circulating levels of the miRNA.Moreover,the absence of large-scale,standardized clinical studies undermines the comparability of existing data.Despite these limits,the literature analysis clearly indicates the need to expand research into miR-375 modulation strategies in humans,as integrating miR-375 with other diagnostic and therapeutic technologies could enhance its clinical relevance.Such strategies may support more personalized and timely interventions for treating diabetes and its complications,ultimately benefiting patient outcomes and contributing to the sustainability of global healthcare systems.展开更多
基金financial support from SATREPS project(vote number:R.J130000.7801.4L977)KPM-UTM Grant(vote number:R.J130000.7301.4L997).
文摘The treatment of POME related contamination is complicated due to its high organic contents and complex composition.Membrane technology is a prominent method for removing POME contaminants on account of its efficiency in removing suspended particles,organic substances,and contaminants from wastewater,leading to the production of high-quality treated effluent.It is crucial to achieve efficient POME treatment with minimum fouling through membrane advancement to ensure the sustainability for large-scale applications.This article comprehensively analyses the latest advancements in membrane technology for the treatment of POME.A wide range of membrane types including forward osmosis,microfiltration,ultrafiltration,nanofiltration,reverse osmosis,membrane bioreactor,photocatalytic membrane reactor,and their combinations is discussed in terms of the innovative design,treatment efficiencies and antifouling properties.The strategies for antifouling membranes such as self-healing and self-cleaning membranes are discussed.In addition to discussing the obstacles that impede the broad implementation of novel membrane tech nologies in POME treatment,the article concludes by delineating potential avenues for future research and policy considerations.The understanding and insights are expected to enhance the application ofmembrane-basedmethods in order to treat POME more efficiently;this will be instrumental in the reduction of environmental pollution.
文摘On July 2^(nd),2025,32 scientists representing 15 countries gathered at Tartu,Estonia to make on-site endorsements for the Global ONCE(Ocean Negative Carbon Emissions)Program at the 12th INTECOL Wetlands Conference.This marks a significant milestone for ONCE in establishing a systematic framework for coastal wetland carbon sequestration research and global collaboration(Figs.1,2).Coastal wetlands are critical transition zones linking terrestrial and marine ecosystems,yet they face severe degradation from anthropogenic land-based activities and sea level rise that propagate impacts to the ocean.As a UN Ocean Decade Program,the Global ONCE Program champions interdisciplinary and cross-regional collaboration to enhance carbon sequestration in the ocean and coastal wetlands through science and innovation.Aligned with the Tartu Declaration on Wetlands that includes resolutions to promote the rights of global wetlands(especially peatlands)and advance the discipline of wetland science based on facts,this initiative addresses key knowledge gaps in land-ocean interactions.The goal is to harness the full potential of coastal wetlands and ocean systems for climate mitigation,thereby laying a scientific foundation for international policy formulation and implementation.
基金supported by the National Natural Science Foundation of China(U22A20443)the Heilongjiang Provincial Research Institutes Scientific Research Operating Expenses Project,China(CZKYF2023-1-B020)+1 种基金the Key Research and Development Plan Project of Heilongjiang Province,China(GA23B015)the Young Scientists Fund of the National Natural Science Foundation of China(32201717)。
文摘Caffeic acid-O-methyltransferase(COMT)is a crucial enzyme in the phenylpropanoid metabolic pathway,with significant roles in both the lignin and coumarin pathways.The function of COMT in plant disease resistance has been demonstrated in several species.Our research identified the potato COMT gene family on a genome-wide scale and StCOMT1 as a candidate gene for enhancing potato disease resistance under DON induction through phylogenetic analyses combined with previously identified metabolic differences and weighted gene co-expression network analysis(WGCNA)results.In order to better understand the function of StCOMT1,heterologous expression and overexpression assays were conducted.StCOMT1 is localized in chloroplasts and was found to catalyze the methylation of substrates to produce ferulic acid and melatonin in vitro.Physiological parameters showed that,compared with wild-type potato plants,StCOMT1-overexpressing plants infected with Fusarium sporotrichioides exhibited smaller lesion areas and lower reactive oxygen species(ROS)levels.High-performance liquid chromatography(HPLC)and RT-qPCR analyses revealed organ-specific accumulation of coumarin-related compounds and organ-specific expression of their corresponding genes in StCOMT1-overexpressing plants post-inoculation.The results indicate that StCOMT1 overexpression in potatoes enhanced resistance to F.sporotrichioides by enhancing reactive oxygen species clearance and promoting organ-specific accumulation of coumarin-related compounds.
基金funded by the National Natural Science Foundation of China(NNSFC)under Grant Numbers 42322408,42188101,and 42441809Additional support was provided by the Climbing Program of the National Space Science Center(NSSC,Grant No.E4PD3005)as well as the Specialized Research Fund for State Key Laboratories of China.
文摘A large-scale view of the magnetospheric cusp is expected to be obtained by the Soft X-ray Imager(SXI)onboard the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE).However,it is challenging to trace the three-dimensional cusp boundary from a two-dimensional X-ray image because the detected X-ray signals will be integrated along the line of sight.In this work,a global magnetohydrodynamic code was used to simulate the X-ray images and photon count images,assuming an interplanetary magnetic field with a pure Bz component.The assumption of an elliptic cusp boundary at a given altitude was used to trace the equatorward and poleward boundaries of the cusp from a simulated X-ray image.The average discrepancy was less than 0.1 RE.To reduce the influence of instrument effects and cosmic X-ray backgrounds,image denoising was considered before applying the method above to SXI photon count images.The cusp boundaries were reasonably reconstructed from the noisy X-ray image.
基金Project supported by the National Key R&D Program of China(2022YFC2905800)the National Natural Science Foundation of China(52174242)the National Youth Talent Support Program(QNBJ-2023-03)。
文摘Bayan Obo rare earth mine is the largest light rare earth resource worldwide,primarily extracts rare earth elements(REEs)from mixed RE concentrates with bastnaesite and monazite.Nevertheless,the adoption of the concentrated sulfuric acid roasting metallurgical process has resulted in damage to the environment.Therefore,this paper adopted the method of selective mineral phase transformation(MPT)followed by enhanced micro-flotation.By determining the optimal MPT co nditions,the flotation recovery of bastnaesite-roasted products by the collector(phthalic acid,PA)is improved,and the enhanced separation of bastnaesite with monazite is realized.The results show that with the increase of roasting temperature and time,the bastnaesite decomposition product is CeOF and monazite does not change significantly.Subsequent micro-flotation exhibits a gradual decline in the PA consumption of bastnaesiteroasted products,while the flotation recovery of monazite-roasted products remains poor.The artificial mixed ore experiments result in a CeOF foam product with a content of 94.14%and a recovery of 85.80%,and a monazite tank product with a content of 73.53%and a recovery of 87.87%.Compared with the preroasting ore,the surface and interior of bastnaesite-roasted products develop numerous cracks and porosities,and no obvious structural damage is observed in monazite-roasted particles.As the roasting temperature increases,the mineral particles undergo recrystallization or closure,reducing the specific surface area of bastnaesite-roasted products and enhancing hydrophobicity,leading to diminished PA consumption.Fourier transform infrared and other flotation-relation tests show that PA is chemisorbed on the surface of CeOF.The MPT conditions are optimized in this study,which provides a reference for further advancing the efficient separation of bastnaesite and monazite.
基金supported by the National Natural Science Foundation of China(No.52370112).
文摘In order to address the evolving emission characteristics of oxygenated volatile organic compounds(OVOCs),it is essential to develop adsorbent materials specifically designed for the efficient adsorption of OVOCs with large kinetic diameters.In this study,we used co-pyrolysis to prepare a series of graded porous carbon materials with well-developed micropores by adjusting the doping ratios of root nodules and pretreated cellulose.The material with root nodule to cellulose mass ratio of 1:1(TCC-RN-1)exhibited the highest saturated adsorption capacity for butyl acetate(834 mg/g).This can be attributed to enhanced pore size distribution from nodule doping,which facilitates the development of a micropore-graded structure.Additionally,the nodules acted as auxiliary activating agents that enhanced the KOH micropore regulation effect during the activation stage,resulting in the highest micropore volume(0.863 cm^(3)/g).The doping of root nodules facilitated the formation of additional defects on the surface of the porous carbon material,leading to a more disordered arrangement that improved pollutant adsorption.Furthermore,TCC-RN-1 demonstrated good thermal stability in an air atmosphere,main-taining a butyl acetate adsorption capacity exceeding 95%after five adsorption-desorption cycles.This indicates its favorable potential for industrial applications.
基金support from the Research Committee of The Hong Kong Polytechnic University(Project codes:RMJK and 4-ZZSJ)supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region,China(Project No.PolyU15212523).
文摘Additive manufacturing(AM),with its high flexibility,cost-effectiveness,and customization,significantly accelerates the advancement of nanogenerators,contributing to sustainable energy solutions and the Internet of Things.In this review,an in-depth analysis of AM for piezoelectric and triboelectric nanogenerators is presented from the perspectives of fundamental mechanisms,recent advancements,and future prospects.It highlights AM-enabled advantages of versatility across materials,structural topology optimization,microstructure design,and integrated printing,which enhance critical performance indicators of nanogenerators,such as surface charge density and piezoelectric constant,thereby improving device performance compared to conventional fabrication.Common AM techniques for nanogenerators,including fused deposition modeling,direct ink writing,stereolithography,and digital light processing,are systematically examined in terms of their working principles,improved metrics(output voltage/current,power density),theoretical explanation,and application scopes.Hierarchical relationships connecting AM technologies with performance optimization and applications of nanogenerators are elucidated,providing a solid foundation for advancements in energy harvesting,self-powered sensors,wearable devices,and human-machine interaction.Furthermore,the challenges related to fabrication quality,cross-scale manufacturing,processing efficiency,and industrial deployment are critically discussed.Finally,the future prospects of AM for nanogenerators are explored,aiming to foster continuous progress and innovation in this field.
基金supported by the National Natural Science Foundation of China(No.51878292).
文摘Large-scale CO_(2)emissions have exacerbated the greenhouse effect,reinforcing the critical need for efficient CO_(2)mitigation methods.Plasma-catalytic technology enables CO_(2)conversion under mild conditions,especially for CO_(2)methanation(the Sabatier reaction),which has attracted significant attention due to its economic benefits and the potential for safe energy transportation via existing natural gas pipelines.The development of high-performance CO_(2)methanation catalysts remains an ongoing and long-term objective,and there is a lack of adequate in-situ characterization techniques to investigate the mechanisms.This study focuses on the Ni/La_(2)O_(3)(LN)catalyst and introduces two CO_(2)activation strategies through F and Na modifications:the Ni-Ov-Ni site activation with electron transfer from Ni0 under low-power conditions and basic site activation under high-power conditions.The LN-NaF catalysts enhance CO_(2)methanation activity across the entire power range compared to LN,achieving a CO_(2)conversion of 86.3%and CH4 selectivity of 99.4%.Additionally,LN-F(h)reaches a CH4 yield 4.15 times higher than that of LN at low power.Furthermore,in-situ diffuse reflectance infrared Fourier transform(DRIFT)spectroscopy with a self-made reactor are performed under plasma-catalytic conditions to reveal the CO_(2)adsorption and conversion mechanisms,indicating that different dopants(F,Na,and NaF)exhibit promoting effects on different intermediates,resulting in variations in CO_(2)methanation activity.This study provides valuable insights for improving catalyst performance and a thorough comprehension of mechanisms in CO_(2)methanation.
文摘Background and purpose: Lifelong endurance exercise is generally associated with cardiovascular health benefits.However, recent studies suggest that prolonged high-volume training may contribute to coronary atherosclerosis,even in athletes with low traditional cardiovascular risk. This case report aims to explore the cardiovascular status of a master endurance athlete with an exceptionally high lifetime training volume, in light of recent concerns raised in the literature.Methods: We present the case of a 60-year-old recreational male marathon runner with no history of cardiovascular disease, who completed over 500 marathons between the ages of 30 and 60 years, covering ~127 000-km running. In 2024 alone, he completed 60 marathons. Cardiovascular evaluation included clinical risk assessment and coronary computed tomography angiography(CTCA).Results: The runner was asymptomatic, had a low ESC-SCORE2(3.3%), a favorable lipid profile, and normal levels of high-sensitivity C-reactive protein and lipoprotein(a). CTCA revealed no evidence of calcified, mixed, or non-calcified coronary plaques.Conclusions: This case highlights that some master athletes may demonstrate resilience to coronary atherosclerosis despite decades of high training volume. In low-risk individuals, prolonged endurance training alone may not necessarily lead to coronary artery disease, emphasizing the need for individualized cardiovascular screening strategies.
文摘Objective To report the first Bahrain national registry for ART treatments initiated from January 1, 2000 to December 31, 2005. Methods The ＂World Report on ART＂ forms, prepared by the International Committee for Monitoring Assisted Reproductive Technology （ICMART）, were filled from database records of all procedures and their respective outcome carried out at Banoon ART Centre, the Military Hospital, Bahrain during the period of 2000-2006. Results A total of 1490 completed cycles were performed. ICSI constituted 42.68% （636）, IVF constituted 35.50% （529）, while frozen-thawed embryo replacement cycles represented only 21.18% （325） of all ART cycles. The clinical pregnancy rates per transfer for IVF and ICSI cycles were 26.65% and 21.70%, respectively. The distribution of singleton, twin and triplet deliveries for IVF,, ICSI and FET combined were 80. 0%, 16.3% and 3.7%, respectively. The average delivery rate per clinical pregnancy for fresh and frozen cycles was 57.3%. As a result of ART services, 266 neonates were born. Complications of ART were solely due to ovarian hyperstimulation syndrome （OHSS） which constituted 2.26% of all aspirated cycles. Conclusion Multiple pregnancy rate was high due to transferring 〉3 embryos. Pregnancy loss and OHSS were relatively high thus preventative measures were recommended. This report paves the way for the other IVF centers in Bahrain to provide their own data for the national ART registry.
基金supported by the National Key Research and Development Program(No.2022YFD2001704).
文摘Simultaneous localization and mapping(SLAM)is one of the most attractive research hotspots in the field of robotics,and it is also a prerequisite for the autonomous navigation of robots.It can significantly improve the autonomous navigation ability of mobile robots and their adaptability to different application environments and contribute to the realization of real-time obstacle avoidance and dynamic path planning.Moreover,the application of SLAM technology has expanded from industrial production,intelligent transportation,special operations and other fields to agricultural environments,such as autonomous navigation,independent weeding,three-dimen-sional(3D)mapping,and independent harvesting.This paper mainly introduces the principle,sys-tem framework,latest development and application of SLAM technology,especially in agricultural environments.Firstly,the system framework and theory of the SLAM algorithm are introduced,and the SLAM algorithm is described in detail according to different sensor types.Then,the devel-opment and application of SLAM in the agricultural environment are summarized from two aspects:environment map construction,and localization and navigation of agricultural robots.Finally,the challenges and future research directions of SLAM in the agricultural environment are discussed.
基金supported by the European Union(EU)European Social Fund(ESF)fund as part of the“Kulku-rin Valssi”Project.
文摘Objective:The main objective of this project was to studyhow to secure the wandering of elderly persons diagnosed with dementia caused by Alzheimer’s disease by using healthcare technologies. Methods:The study was carried out during a three-year period (2008-2011) in the region of South Ostrobothnia, Finland. Thirty-two elderly persons living at home and diagnosed with Alzheimer’s disease participated in the study. The ages of the intervention group ranged from 66 to 90 years;the average age was 81 years. A total of 63 different home care devices including 24 location based technologies were tested during the intervention.The choice of technology used was based on the individual needs of the elderly person. Results:Participants with mild stage memory impairment were able to use and benefit from the technology installed during the intervention to live more independently.The most useful devices were those that operated within the home. Nine of ten users of door alarm systems, five of nine users of GPS systems and all users of GSM systems were satisfied with the technologies. Conclusions:Location based alarm and access control technology can have a positive impact on the lives of elderly persons suffering from dementia. When chosen appropriately, technology can help to reduce or eliminate the wandering often associated with dementia.Regardless of the technology used, it should be installed when the elderly person is at the early stages of dementia;at later stages of the disease it is usually impossible for the elderly to adequately adopt the device.
基金the National Natural Science Foundation of China(Nos.52105421 and 52373050)the Guangdong Provincial Natural Science Foundation,China(No.2022A1515011621)+1 种基金the Science and Technology Projects in Guangzhou,China(Nos.202102080330 and 2024A04J6446)the Fundamental Research Funds for the Central Universities,Sun Yat-sen University(No.22qntd0101).
文摘Wireless millirobots engineered to infiltrate intricate vascular networks within living organisms,particularly within constricted and confined spaces,hold immense promise for the future of medical treatments.However,with their multifaceted and intricate designs,some robots often grapple with motion and functionality issues when confronted with tight spaces characterized by small cross-sectional dimensions.In this study,drawing inspiration from the high aspect ratio and undulating swimming patterns of snakes,a millimeter-scale,snake-like robot was designed and fabricated via a combination of extrusion-based four-dimensional(4D)printing and magnetic-responsive intelligent functional inks.A sophisticated motion control strategy was also developed,which enables the robots to perform various dynamic movements,such as undulating swimming,precise turns,graceful circular motions,and coordinated cluster movements,under diverse magnetic field variations.As a potential application,the snake robot can navigate and release drugs in a model coronary intervention vessel with tortuous channels and fluid filling.The novel design and promising applications of this snake robot are invaluable tools in future medical surgeries and interventions.
基金Project supported by the Brazilian National Council for Scientific and Technological Development/CNPq(405982/2022-4 and 303992/2021-2)。
文摘Ouricuri endocarp was utilized as a biosorbent for the recovery of europium(Eu(Ⅲ))from aqueous solutions and rare earth elements(REEs)from authentic leachate derived from phosphogypsum,which encompasses various REEs.Various characterization techniques were applied to analyze the physicochemical and adsorptive properties of the biosorbent.The results indicate that the adsorption kinetic data conform well to the pseudo-first-order model,while the Liu model describes the equilibrium data well.Ouricuri endocarp and Eu interactions are favorable and spontaneous.The maximum adsorption capacity for Eu(Ⅲ)is determined to be 22.9 mg/g according to the Liu model.Based on experimental results and adsorbent characteristics,the proposed adsorption mechanisms between ouricuri endocarp and Eu include ion exchange and electrostatic interactions as the primary mechanisms.The Eu(Ⅲ)recovery is also feasible as a continuous flow process demonstrating inclined breakthrough curves and lower values of the length of the mass transfer zone.Ouricuri endocarp demonstrates its selectivity for recovering various REEs from authentic phosphogypsum leachate.It achieves a 98%recovery rate for Eu and approximately 60%for Ce,La,and Nd,affirming its efficacy under real-world conditions.Finally,concentration of REE was done by ashing loaded ouricuri endocarp,and a solid with around 34%(in weight)of REE is obtained.
基金financial support from the National Natural Science Foundation of China(Nos.22108258 and 52003251)Program for Science&Technology Innovation Talents in Universities of Henan Province(24HASTIT004)+1 种基金Outstanding Youth Fund of Henan Scientific Committee(222300420085)Science and Technology Joint Project of Henan Province(222301420041)。
文摘Mixed matrix membranes(MMMs)have demonstrated significant promise in energy-intensive gas separations by amalgamating the unique properties of fillers with the facile processability of polymers.However,achieving a simultaneous enhancement of permeability and selectivity remains a formidable challenge,due to the difficulty of achieving an optimal match between polymers and fillers.In this study,we incorporate a porous carbon-based zinc oxide composite(C@ZnO)into high-permeability polymers of intrinsic microporosity(PIMs)to fabricate MMMs.The dipole–dipole interaction between C@ZnO and PIMs ensures their exceptional compatibility,mitigating the formation of non-selective voids in the resulting MMMs.Concurrently,C@ZnO with abundant interconnected pores can provide additional low-resistance pathways for gas transport in MMMs.As a result,the CO_(2) permeability of the optimized C@ZnO/PIM-1 MMMs is elevated to 13,215 barrer,while the CO_(2)/N_(2) and CO_(2)/CH_(4) selectivity reached 21.5 and 14.4,respectively,substantially surpassing the 2008 Robeson upper bound.Additionally,molecular simulation results further corroborate that the augmented membrane gas selectivity is attributed to the superior CO_(2) affinity of C@ZnO.In summary,we believe that this work not only expands the application of MMMs for gas separation but also heralds a paradigm shift in the application of porous carbon materials.
基金supported by the National Natural Science Foundation of China(No.5217-4205)Shaanxi Provincial Outstanding Youth Science Fund Project(No.2023-JC-JQ-40)+4 种基金National Key Research and Development Project(No.2023YFC3009004)Key Project of Shaanxi Provincial Department of Education(No.22JY040)Xinjiang Uygur Autonomous Region Key Research and Development Task Special Project(No.2022B01034-3)Key Laboratory of Green Coal Mining in Xinjiang,Ministry of Education(No.KLXGY-KA2404)Shaanxi Provincial Key Research and Development Task General Project(No.2024GX–YBXM-490)。
文摘In this study,to better decide the effect of coal seam dip angle upon the dynamic change of the crossfusion in gas transport and storage areas during the progress of working face in the high gas thick coal seam,a two-dimensional physical simulation experiment regarded as the theoretical research was conducted to properly explore the variation law of overburden fracture.The results demonstrated that the boundary of the gas transport zone was located in the region of fracture separation.The boundary of the gas storage area was located in the abrupt penetration zone.Also,according to the information theory,the state of the gas transport and storage areas was determined by the changing trend of the fracture rate and fracture entropy.The mathematical representation model of the dip effect in gas transport and storage areas was established.The criteria upon which the regional location of the gas transport area and gas storage area can be based were put forward.The cross-fusion evolution process of the dip effect in gas transport and storage areas was revealed as well.The research results could provide guidance for realising directional and accurate gas extraction.
基金supported by the Faculty Startup Fund from Jining Medical University,the Shandong Provincial Natural Science Foundation,China(Grant No.ZR2023QC309)the National Natural Science Foundation of China(Grant No.32102236)。
文摘Myeloblastosis(MYB)transcription factors,particularly those in the R2R3 MYB subclass,are pivotal in plant growth,development,and environmental stress responses.As one of the largest transcription factor families in plants,the MYB family significantly regulates plant secondary metabolism,including the biosynthetic pathways for phenylpropanoids,which are crucial for stress resistance.This review presents a comprehensive overview of MYB transcription factor classification and their regulatory mechanisms in plant metabolism and stress responses.We discuss the roles of MYB transcription factors in biotic stress resistance,such as defense against pathogens and pests,and in abiotic stress tolerance,including responses to drought and salinity.Special attention is given to the interactions of R2R3 MYB with other transcription factors and co-repressors,focusing on how these synergistic or antagonistic relationships modulate physiological processes.The multifunctional role of R2R3 MYBs in stress responses positions them as promising targets for enhancing crop resilience through genetic breeding.Furthermore,this review highlights potential applications of MYB transcription factors in developing stress-resistant crops and their utility in plant resistant breeding programs.
基金the Ministry of Human Resource and Development (MHRD) Government of India for funding
文摘In the current transformative era of biomedicine,hydrogels have established their presence in biomaterials due to their superior biocompatibility,tuneability and resemblance with native tissue.However,hydrogels typically exhibit poor conductivity due to their hydrophilic polymer structure.Electrical conductivity provides an important enhancement to the properties of hydrogel-based systems in various biomedical applications such as drug delivery and tissue engineering.Consequently,researchers are developing combinatorial strategies to develop electrically responsive“SMART”systems to improve the therapeutic efficacy of biomolecules.Electrically conductive hydrogels have been explored for various drug delivery applications,enabling higher loading of therapeutic cargo with on-demand delivery.This review emphasizes the properties,mechanisms,fabrication techniques and recent advancements of electrically responsive“SMART”systems aiding on-site drug delivery applications.Additionally,it covers prospects for the successful translation of these systems into clinical research.
文摘Selecting the embryo with the highest implantation potential is a top priority in in-vitro fertilization(IVF)centers.Few studies have explored the relationship between day 5 blastocyst morphokinetics and implantation outcomes[1].Despite numerous time-lapse studies,the findings often conflict due to differences in patient demographics,lab conditions,and protocols,such as oxygen concentration[2].Thus,there is ongoing debate regarding which parameters are most predictive of implantation.
文摘Diabetes is a growing global health concern,calling for improved diagnostic and therapeutic strategies.Of the emerging possible biomarkers,microRNA 375(miR-375)has gained attention for its pivotal role in pancreaticβcell development and function,and its altered blood levels followingβcell injury.This review summarizes the current knowledge on the role of miR-375 in insulin regulation,its correlation with diabetes,and its clinical potential.Despite its well-known role inβcell biology,literature analyses have failed to reveal a consistent correlation between the circulating levels of miR-375 and diabetes.A key limitation lies in the lack ofβcell specificity of miR-375,along with its modulation by diabetes-related complications,which influences circulating levels of the miRNA.Moreover,the absence of large-scale,standardized clinical studies undermines the comparability of existing data.Despite these limits,the literature analysis clearly indicates the need to expand research into miR-375 modulation strategies in humans,as integrating miR-375 with other diagnostic and therapeutic technologies could enhance its clinical relevance.Such strategies may support more personalized and timely interventions for treating diabetes and its complications,ultimately benefiting patient outcomes and contributing to the sustainability of global healthcare systems.
