The development of pattern-based traditional Chinese medicine(TCM)compound preparations constitutes a core domain that represents the principle of pattern differentiation-based treatment,a hallmark of TCM.However,the ...The development of pattern-based traditional Chinese medicine(TCM)compound preparations constitutes a core domain that represents the principle of pattern differentiation-based treatment,a hallmark of TCM.However,the field has long been constrained by scientific and regulatory challenges in animal modeling,efficacy evaluation,and clinical positioning.This article proposes a new research and development(R&D)paradigm strategically based on human use experience(HUE)and centered on the patient as the key to overcoming these bottlenecks and achieving high-quality progress.We systematically dissect the traditional problems in this field and demonstrate the pivotal role of high-quality HUE in enabling precise clinical positioning and optimizing R&D pathways(e.g.,applying for exemptions from non-clinical studies).HUE guides the implementation of the“pattern-symptom integration”model.Furthermore,we detail the implementation of the patient-centered concept throughout the process of clinical trial design,collection of patients’experience data,clinical outcome assessment,and benefit-risk assessment.The integrative application of artificial intelligence in the R&D of pattern-based TCM drugs is also specifically explored.By synthesizing the“TCM theory,HUE,and clinical trials”evidence system,this article aims to provide a systematic strategic framework for establishing an R&D pathway that adheres to the intrinsic principles of TCM while simultaneously meeting modern scientific standards.展开更多
The technology of solid-state lighting has developed for decades in various industries.Phosphor,as an element part,determines the application domain of lighting products.For instance,blue and redemitting phosphors are...The technology of solid-state lighting has developed for decades in various industries.Phosphor,as an element part,determines the application domain of lighting products.For instance,blue and redemitting phosphors are required in the process of plant supplementing light,arrow-band emitting phosphors are applied to backlight displays,etc.In this work,a Bi^(3+)-activated blue phosphor was obtained in a symmetrical and co mpact crystal structure of Gd3Sb07(GSO).Then,the co-doping strategy of alkali metal ions(Li^(+),Na^(+),and K^(+))was used to optimize the performance.The result shows that the photoluminescence intensity is increased by 2.1 times and 1.3 times respectively by introducing Li~+and K^(+)ions.Not only that,it also achieves narrow-band emitting with the full width of half-maximum(FWHM)reaching 42 nm through Na^(+)doping,and its excitation peak position also shifts from 322 to 375 nm,which can be well excited by near-ultraviolet(NUV)light emitting diode(LED)chips(365 nm).Meanwhile,the electroluminescence spectrum of GSO:0.6 mol%Bi^(3+),3 wt%Na^(+)matches up to 93.39%of the blue part of the absorption spectrum of chlorophyll a.In summary,the Bi^(3+)-activated blue phosphor reported in this work can synchronously meet the requirements of plant light replenishment and field emission displays.展开更多
OBJECTIVE:To confirm the effectiveness and safety of Shi's manipulation in treating acute and subacute neck pain patients.METHODS:This multicenter,positive controlled,randomized clinical trial has trial and contro...OBJECTIVE:To confirm the effectiveness and safety of Shi's manipulation in treating acute and subacute neck pain patients.METHODS:This multicenter,positive controlled,randomized clinical trial has trial and control groups.There were 240 patients randomly assigned to the trial group and the control group,and both groups received their respective intervention treatment methods for a period of 12 weeks.The time windows for clinical data collection were before treatment,immediately after treatment,3-d 1,2,4,8,and 12-week after treatment,and follow-up was conducted at 26 and 52-week after treatment.The observed indicators used include primary outcome index and secondary outcome index,with the primary outcome index being the assessment of neck pain severity,which is evaluated by patients using Numerical Rating Scale(NRS).Secondary secondary outcome index include,(a)cervical dysfunction index,measured by patients using the Neck Disability Index(NDI)for self-assessment;(b)Cervical activity measurement,measured through the cervical range of motion measurement program on Android mobile system;(c)Satisfaction treatment assessment,determined by the patient's self-evaluation;(d)Safety index,recorded the incidence of adverse reactions and adverse event.Results:The results showed that these efficacy indices were improved in different degrees in both groups.At immediate after intervention,there was significant difference in NRS,NDI,Cervical Range of Motion(ROM)between the two groups(P<0.01),the trial group was superior to the control group.At 3-d after intervention,there was significant difference in NRS,NDI,ROM between the two groups(P<0.01).At 1-week and 2-week after intervention,there was significant difference in NDI and ROM between the two groups(P<0.01).At 4-week and 6-week after intervention,there was significant difference in NDI,ROM between the two groups(P<0.05).At 8-week after intervention,there was significant difference in NDI,lateral-bending and axial-rotation ROM between the two groups(P<0.05).At 12-week after intervention,there was significant difference in NDI between the two groups(P<0.01).At 26-week and 52-week after intervention,there was significant difference in NDI,NRS between the two groups(P<0.01).In addition,the adverse reaction of trial group is significantly lower than that of control group(P<0.05).The satisfaction of patients in the trial group was better than that in the control group(P<0.01).CONCLUSION:Our findings suggest that Shi's manipulation can be a good complementary treatment option in patients with acute and subacute neck pain.展开更多
As the integration of medical big data and artificial intelligence advances,the secure sharing of medical data has become a key driving force for advancing disease research and clinical diagnosis.Federated learning,a ...As the integration of medical big data and artificial intelligence advances,the secure sharing of medical data has become a key driving force for advancing disease research and clinical diagnosis.Federated learning,a distributed approach enabling collaborative data processing without sharing raw data,offers promising solutions to challenges in multi-center medical data sharing.This review summarizes the progress of federated learning in multi-center medical data processing,analyzed from four perspectives:system architectures,data distribution strategies,clinical tasks,and algorithmic models.At the same time,this paper explores the challenges in practical applications,such as data heterogeneity,communication overhead,and privacy concerns.It proposes driving future research development by optimizing algorithms,strengthening privacy protection mechanisms,and enhancing computational efficiency.展开更多
Objective:Hyper-progression recurrence(HPR)after hepatectomy is a specific recurrence pattern associated with extremely poor prognosis in patients with hepatocellular carcinoma(HCC).This study was aimed at investigati...Objective:Hyper-progression recurrence(HPR)after hepatectomy is a specific recurrence pattern associated with extremely poor prognosis in patients with hepatocellular carcinoma(HCC).This study was aimed at investigating the probable risk factors and establishing comprehensive models for formulating clinical strategies.Methods:Overall,16,158 patients with HCC from 8 hospitals were screened,among whom 3,125 patients who underwent R0 resection were included,and divided into development(n=2,113)and validation(n=1,012)cohorts.A comprehensive study of HPR predictive models and biological features was conducted.Results:Among the 3,125 enrolled patients,506(16.19%)developed HPR.The influence of HPR on extremely poor prognosis was reflected by recurrence features,adverse effects on systemic and liver function,and limited therapeutic options.Nine variables closely associated with HPR were identified,and incorporated into nomogram and conditional inference tree models,which successfully achieved pre-and post-operative HPR risk stratification and facilitated clinical decision-making.Multi-dimensional verification also confirmed the predictive accuracy of model combinations and their reliability in clinical applications.Furthermore,biological analyses revealed that HCCs with HPR exhibited hyperactive biological processes,inactive metabolism,and immune exhaustion features,together with high MYCN/HMGA2 co-expression,thereby enhancing understanding of the molecular events leading to HPR and providing valuable knowledge for HPR management.Conclusions:HPR after hepatectomy is associated with extremely poor prognosis and requires substantial attention.We constructed comprehensive predictive models and propose a clinical strategy for guiding HPR prevention and management.展开更多
Mytilus contain abundant antimicrobial peptides(AMPs)that play a key role in the innate immunity.However,heterologous production of these AMPs remains challenging due to their short sequences,multiple disulfide bonds,...Mytilus contain abundant antimicrobial peptides(AMPs)that play a key role in the innate immunity.However,heterologous production of these AMPs remains challenging due to their short sequences,multiple disulfide bonds,and high content of cationic amino acids,which hinder functional expression in prokaryotic systems such as Escherichia coli.To establish a eukaryotic recombinant expression system for the AMPs of mussel and obtain recombinant mussel AMPs for subsequent studies,we reported the successful recombinant expression of myticofensin B1,a novel defensin-like AMP identified previously in Mytiluscoruscus,using the eukaryotic host Pichia pastoris.The codon-optimized gene encoding the mature myticofensin-B1(composed of 65 amino acid residues,including 6 conserved cysteine residues)was cloned into a pPICZαA vector and expressed in P.pastoris GS115.Structural fidelity of the recombinant peptide was confirmed by liquid chromatography-tandem mass spectrometry(LC-MS/MS),showing a molecular weight of 8849.9 Da,which was consistent with the theoretical prediction.Functional assays demonstrated a broad-spectrum antimicrobial activity of the recombinant myticofensin-B1,with stronger inhibition against Gram-negative bacteria.Scanning electron microscopy revealed different effects of the recombinant myticofensin-B1 against different bacteria.In addition,the recombinant myticofensin-B1 exhibited a very low hemolytic activity against sheep red blood cells and weak cytotoxicity against human A549 lung cancer cells.This study establishes P.pastoris as a powerful platform to produce functional mussel AMP and highlights the potential of the recombinant myticofensin-B1 as a therapeutic agent for aquaculture pathogens and infections.展开更多
The cure rate for chronic neurodegenerative diseases remains low,creating an urgent need for improved intervention methods.Recent studies have shown that enhancing mitochondrial function can mitigate the effects of th...The cure rate for chronic neurodegenerative diseases remains low,creating an urgent need for improved intervention methods.Recent studies have shown that enhancing mitochondrial function can mitigate the effects of these diseases.This paper comprehensively reviews the relationship between mitochondrial dysfunction and chronic neurodegenerative diseases,aiming to uncover the potential use of targeted mitochondrial interventions as viable therapeutic options.We detail five targeted mitochondrial intervention strategies for chronic neurodegenerative diseases that act by promoting mitophagy,inhibiting mitochondrial fission,enhancing mitochondrial biogenesis,applying mitochondria-targeting antioxidants,and transplanting mitochondria.Each method has unique advantages and potential limitations,making them suitable for various therapeutic situations.Therapies that promote mitophagy or inhibit mitochondrial fission could be particularly effective in slowing disease progression,especially in the early stages.In contrast,those that enhance mitochondrial biogenesis and apply mitochondria-targeting antioxidants may offer great benefits during the middle stages of the disease by improving cellular antioxidant capacity and energy metabolism.Mitochondrial transplantation,while still experimental,holds great promise for restoring the function of damaged cells.Future research should focus on exploring the mechanisms and effects of these intervention strategies,particularly regarding their safety and efficacy in clinical settings.Additionally,the development of innovative mitochondria-targeting approaches,such as gene editing and nanotechnology,may provide new solutions for treating chronic neurodegenerative diseases.Implementing combined therapeutic strategies that integrate multiple intervention methods could also enhance treatment outcomes.展开更多
The TiB+TiC dual-reinforced B_(4)C/TC4 composite was in-situ fabricated via incorporating 0.5wt%B_(4)C reinforcement during the laser melting deposition process.Different heat treatments of annealing and solid solutio...The TiB+TiC dual-reinforced B_(4)C/TC4 composite was in-situ fabricated via incorporating 0.5wt%B_(4)C reinforcement during the laser melting deposition process.Different heat treatments of annealing and solid solution were used to regulate the microstructure,mechanical properties,and corrosion properties of B_(4)C/TC4 composite.Results show that with the increase in temperature from 500℃to 800°C,partial lamellarα-Ti in the as-deposited sample is gradually transformed into equiaxedα-Ti,accompanied by the disappearance of basketweave microstructure.At 1100°C,a small portion of TiC phase suffers fusion.This composite exhibits the optimal combination of strength and plasticity after annealing at 500℃for 4 h followed by furnace cooling,which is attributed to the stress release effect and the refined basketweave microstructure.However,this composite shows a decline in corrosion resistance after various heat treatments due to grain coarsening and micro-galvanic corrosion.展开更多
In this study,a multifunctional aptamer-conjugated magnetic covalent organic framework(COF)-CuO/Au nanozyme(MCOF-CuO/Au@apt)was developed as a“three-in-one”platform for dual-signal colorimetric and fluorescent detec...In this study,a multifunctional aptamer-conjugated magnetic covalent organic framework(COF)-CuO/Au nanozyme(MCOF-CuO/Au@apt)was developed as a“three-in-one”platform for dual-signal colorimetric and fluorescent detection of Vibrio parahaemolyticus.The nanozyme integrated magnetic separation,peroxidase-like catalytic activity,and specific target recognition through an aptamer-based strategy.Upon binding to V.parahaemolyticus,the catalytic oxidation of tetra-aminophenylethylene(TPE-4A)by the nanozyme was selectively inhibited,resulting in distinct colorimetric and fluorescent signals that significantly enhanced the detection accuracy and reliability.The proposed method exhibited high sensitivity,with limits of detection(LOD)of 21 and 7 CFU/mL for the colorimetric and fluorescent assays,respectively.The performance of this method was validated using real seafood samples,including Penaeus vannamei,Mytilus coruscus,and Crassostrea gigas,which showed high recovery rates(101.11%-107.30%)and excellent reproducibility.The system also demonstrated strong specificity and accuracy under various conditions,confirming its robustness and practical applicability.Collectively,this innovative platform presents a promising solution for the rapid,versatile,and sensitive detection of V.parahaemolyticus in seafood,with considerable potential to advance food safety diagnosis and on-site monitoring.展开更多
This study investigates the reduction in polarization measurement accuracy caused by varying in-cident angles in a liquid crystal variable retarder(LCVR).The phase delay characteristics of the LCVR were examined,with ...This study investigates the reduction in polarization measurement accuracy caused by varying in-cident angles in a liquid crystal variable retarder(LCVR).The phase delay characteristics of the LCVR were examined,with particular emphasis on the influence of different two-dimensional incident angles on phase delay behavior.Building upon the calibration of phase delay under normal incidence,a phase delay calibra-tion model was developed to account for variations in incident angle and driving voltage.A mathematical re-lationship was established between phase delay and the azimuth angle(α)and pitch angle(β).Experimental validation was conducted under three conditions:α=20°,β=0°;α=0°,β=20°;and an arbitrary angle whereα=5°,β=15°.The results demonstrated that the maximum average deviation between theoretical pre-dictions and experimental measurements did not exceed 0.059 rad.The proposed calibration method proved to be both accurate and practical.This approach offers robust support for LCVR parameter calibration and performance optimization in optical systems,particularly in polarization imaging applications.展开更多
Three copper(Ⅱ),nickel and cadmium(Ⅱ)complexes,namely[Cu_(2)(μ-H2dbda)2(phen)2]·2H_(2)O(1),[Ni(μ-H2dbda)(μ-bpb)(H_(2)O)2]n(2),and[Cd(μ-H2dbda)(μ-bpa)]n(3),have been constructed hydrothermally using H4dbda(...Three copper(Ⅱ),nickel and cadmium(Ⅱ)complexes,namely[Cu_(2)(μ-H2dbda)2(phen)2]·2H_(2)O(1),[Ni(μ-H2dbda)(μ-bpb)(H_(2)O)2]n(2),and[Cd(μ-H2dbda)(μ-bpa)]n(3),have been constructed hydrothermally using H4dbda(4,4'-dihydroxy-[1,1'-biphenyl]-3,3'-dicarboxylic acid),phen(1,10-phenanthroline),bpb(1,4-bis(pyrid-4-yl)benzene),bpa(bis(4-pyridyl)amine),and copper,nickel and cadmium chlorides at 160℃.The products were isolated as stable crystalline solids and were characterized by IR spectra,elemental analyses,thermogravimetric analyses,and singlecrystal X-ray diffraction analyses.Single-crystal X-ray diffraction analyses revealed that three complexes crystallize in the monoclinic P21/n,tetragonal I42d,and orthorhombic P21212 space groups.The complexes exhibit molecular dimers(1)or 2D metal-organic networks(2 and 3).The catalytic performances in the Knoevenagel reaction of these complexes were investigated.Complex 1 exhibits an effective catalytic activity and excellent reusability as a heterogeneous catalyst in the Knoevenagel reaction at room temperature.CCDC:2463800,1;2463801,2;2463802,3.展开更多
Laser powder bed fusion(LPBF)is highly suitable for forming 18Ni300 mold steel,thanks to its excellent capability in manufacturing complex shapes and outstanding capacity for regulating microstructures.It is widely us...Laser powder bed fusion(LPBF)is highly suitable for forming 18Ni300 mold steel,thanks to its excellent capability in manufacturing complex shapes and outstanding capacity for regulating microstructures.It is widely used in fields such as injection molding,die casting,and stamping dies.Adding reinforcing particles into steel is an effective means to improve its performance.Nb/18Ni300 composites were fabricated by LPBF using two kinds of Nb powders with different particle sizes,and their microstructures and properties were studied.The results show that the unmelted Nb particles are uniformly distributed in the 18Ni300 matrix and the grains are refined,which is particularly pronounced with fine Nb particles.In addition,element diffusion occurs between the particles and the matrix.The main phases of the base alloy are α-Fe and a small amount of γ-Fe.With the addition of Nb,part of the α-Fe is transformed into γ-Fe,and unmelted Nb phases appear.The addition of Nb also enhances the hardness and wear resistance of the composites but slightly reduces their tensile properties.After aging treatment,the molten pools and grain boundaries become blurred,grains are further refined,and the interfaces around the particles are thinned.The aging treatment also promotes the formation of reverted austenite.The hardness,ultimate tensile strength,and volumetric wear rate of the base alloy reach 51.9 HRC,1704 MPa,and 17.8×10^(-6) mm^(3)/(N·m),respectively.In contrast,the sample added with fine Nb particles has the highest hardness(56.1 HRC),ultimate tensile strength(1892 MPa)and yield strength(1842 MPa),and the volume wear rate of the sample added with coarse Nb particles is reduced by 90%to 1.7×10^(-6) mm^(3)/(N·m).展开更多
Purpose-This study investigates the impact of flagship trains on high-speed railway capacity utilization and develops a brand value-oriented optimization framework that balances service quality enhancement with operat...Purpose-This study investigates the impact of flagship trains on high-speed railway capacity utilization and develops a brand value-oriented optimization framework that balances service quality enhancement with operational efficiency.Design/methodology/approach-A mathematical optimization model based on integer programming is developed,incorporating flagship train constraints into capacity optimization.Case studies compare scenarios with and without flagship train considerations using the Beijing-Shanghai High-Speed Railway data across 20 experimental groups.Findings-Operating flagship trains with hourly departure constraints results in an average decrease of 0.9 trains and an 8.4%reduction in capacity utilization rate.When scheduling 2 flagship trains within a 2-h timeframe,capacity utilization decreases from 86.43%to 83.73%,quantifying the trade-off between brand positioning and operational capacity.Originality/value-This research provides the first quantitative framework for brand value-oriented railway capacity optimization,establishing clear definitions for flagship trains and mathematical foundations for evaluating service quality versus efficiency trade-offs.The findings offer practical decision support for railway operators balancing competitive positioning with capacity maximization.展开更多
[Objectives]To provide a reference for the efficient use of wild Paeonia suffruticosa germplasm resources and the scientific selection of parents.[Methods]This study systematically evaluated cross-compatibility by con...[Objectives]To provide a reference for the efficient use of wild Paeonia suffruticosa germplasm resources and the scientific selection of parents.[Methods]This study systematically evaluated cross-compatibility by conducting interspecific crosses among the major wild species subsect.Delavayanae(Paeonia delavayi,Paeonia lutea,Paeonia potaninii,and Paeonia ludlowii)as well as reciprocal crosses between these species and cultivated varieties from the subsect.Vaginatae.[Results]Crosses among P.delavayi,P.lutea,and P.potaninii generally exhibited good seed set,with the resulting seeds showing a high emergence rate.In contrast,crosses involving P.ludlowii as a parent produced only a limited number of seeds,none of which germinated.In crosses with cultivated varieties where the wild species served as the maternal parent,the average seed set ranked as follows:P.lutea>P.delavayi>P.ludlowii>P.potaninii.When wild species were used as paternal parent,the average seed set ranked as follows:P.potaninii>P.lutea>P.delavayi>P.ludlowii.On the whole,most crosses between wild species of subsect.Delavayanae and cultivated varieties achieved normal seed set,demonstrating a certain degree of cross-compatibility.However,when the wild species served as the maternal parent,both the seed set and seedling emergence rate were superior to those in the reciprocal crosses(with wild species as the paternal parent).[Conclusions]Significant differences in cross-compatibility were observed among species within Paeonia subsect.Delavayanae.In addition,a significant maternal effect was identified in crosses between wild species of this subsection and cultivated varieties.These findings suggest that by selecting highly compatible combinations,there remains considerable potential for utilizing these wild species in peony breeding.展开更多
In this paper,the joint design of transmit and receive beamformers for transmit subaperturing multiple-input-multiple-output(TS-MIMO)radar is investigated,aiming to enhance its low probability of intercept(LPI)capabil...In this paper,the joint design of transmit and receive beamformers for transmit subaperturing multiple-input-multiple-output(TS-MIMO)radar is investigated,aiming to enhance its low probability of intercept(LPI)capability.The main objective is to simultaneously minimize the transmission power,suppress the transmit sidelobe levels,and minimize the probability of intercept,thus bolstering the LPI performance of the radar system while maintaining the desired target detection performance.An alternative optimization method is proposed to jointly optimize the transmit and receive beamformers,yielding an unified LPI optimization framework.Particularly,the proposed iterative algorithm based on the Lagrange duality theory for transmit beamforming is more efficient than the conventional convex optimization method.Numerical experiments highlight the effectiveness of the proposed approach in sidelobe suppression and computational efficiency.展开更多
Shallow landslides are strongly controlled by near-surface lithological variability,yet conventional geological maps are often too generalized to support accurate susceptibility assessment in complex terrains.This rev...Shallow landslides are strongly controlled by near-surface lithological variability,yet conventional geological maps are often too generalized to support accurate susceptibility assessment in complex terrains.This review synthesizes recent advances in remote sensing–based lithological mapping and evaluates their integration into landslide susceptibility modeling.Evidence from the literature indicates that remote sensing-derived lithological products,particularly those incorporating mineralogical information and higher spatial resolution,consistently outperform traditional geological maps in improving model accuracy and spatial detail,especially in heterogeneous environments.However,key challenges remain,including scale mismatches between surface observations and subsurface controls,limited ground validation,uncertainty propagation,and restricted model transferability across regions.The review identifies multi-sensor data fusion and explainable machine learning as the most promising directions for advancing lithological discrimination and model reliability.Future progress depends on integrating remote sensing with process-based understanding,improving validation strategies,and standardizing uncertainty reporting.These developments are essential for enabling more robust,scalable,and operationally relevant landslide susceptibility assessments in complex terrains.Lastly,we describe the directions of research that focus on multi-sensor fusion,explainable machine learning,UAV(Unmanned Aerial Vehicle)-enabled validation,and standardized uncertainty reporting that can help articulate landslide susceptibility assessment,making them even more robust and operationally significant.展开更多
The development of materials with excellent microwave absorption(MWA)and electromagnetic interference(EMI)shielding performances has currently received attention.Herein,mesophase pitch-based carbon foam(MPCF)with 3D i...The development of materials with excellent microwave absorption(MWA)and electromagnetic interference(EMI)shielding performances has currently received attention.Herein,mesophase pitch-based carbon foam(MPCF)with 3D interconnected pore structure was prepared through the high pressure pyrolysis of mesophase coal tar pitch.It is found that the 3D interconnected cellular pores of MPCF facilitate multiple reflections of electromagnetic waves,which results in the minimum reflection loss(RLmin)value of MPCF reaches-37.84 dB with the effective absorption bandwidth(EAB)of 5.44 GHz at a thickness of 2.70 mm,and the total average electromagnetic shielding effectiveness(SE_(T))under 3.00 mm thickness achieves 26.52 dB in X-band.Subsequently,MPCF is activated by KOH to obtain activated carbon foam(A-MPCF).The average SE_(T)of A-MPCF achieves 103.00 dB for abundant nanopores on the pore cell walls,which leads to a transition from the multiple reflections of electromagnetic waves on the walls to diffuse reflection.Unfortunately,the reflection coefficient(R)of A-MPCF increases from 0.78 to 0.90.To reduce the R value,Fe_(3)O_(4)/A-MPCF was fabricated via the in situ growth of nano Fe_(3)O_(4)on A-MPCF.Consequently,the R value of Fe_(3)O_(4)/A-MPCF was reduced from 0.90 to 0.74,whereas the MWA performance was only slightly decreased.This work proposes a simple strategy for simultaneously adjusting MWA and EMI shielding performances of materials.展开更多
This paper provides a systematic review of the histochemical localization,content characteristics,and influencing factors of saponins in Pseudostellaria heterophylla based on an extensive literature survey.It provides...This paper provides a systematic review of the histochemical localization,content characteristics,and influencing factors of saponins in Pseudostellaria heterophylla based on an extensive literature survey.It provides an in-depth analysis and summary of the effects of biological factors,environmental conditions,agronomic practices,processing methods,and continuous cropping obstacles on the synthesis of P.heterophylla saponins,as well as their underlying mechanisms.Based on identified gaps in the current literature,future research directions and prospects are proposed.The findings of this review offer valuable insights for advancing the understanding of the saponin biosynthesis mechanisms in P.heterophylla and for enhancing its quality.展开更多
High-sulfur iron concentrates emit SO_(2)into the flue gas during pellet induration.To investigate the effect of the SO_(2)cycle on pellet quality in the grate-kiln process,sulfur balance analysis,thermodynamic calcul...High-sulfur iron concentrates emit SO_(2)into the flue gas during pellet induration.To investigate the effect of the SO_(2)cycle on pellet quality in the grate-kiln process,sulfur balance analysis,thermodynamic calculations,and pellet production experiments under simulated flue gas circulation conditions were conducted.The results indicated that SO_(2)circulation inhibited desulfurization and deteriorated pellet strength.SO_(2)absorption increased the pellet sulfur content to 0.70 wt.%during the downdraft drying phase,and the absorption could be aggravated by the moisture.The desulfurization rate of the preheating process was also decreased to 16.67%,resulting from the refractory sulfate generation.Sulfur content of the roasted pellets dropped to 0.13 wt.%because of the aluminosilicate generation.The finished pellet sulfur content further decreased to 0.08 wt.%due to the fresh air during the cooling process.Eventually,optimization measures were proposed when high-sulfur iron concentrates were used for oxidized pellet preparation.展开更多
The Neogene Shawan Formation in the Chepaizi Uplift of the Junggar Basin(NW China)has obtained high oil flow,demonstrating a good potential for oil and gas exploration.The multi-source hydrocarbon generation backgroun...The Neogene Shawan Formation in the Chepaizi Uplift of the Junggar Basin(NW China)has obtained high oil flow,demonstrating a good potential for oil and gas exploration.The multi-source hydrocarbon generation background and strong tectonic activity have led to the simultaneous production of heavy oil and light oil from multi-layer in the area,which makes it very difficult to identify oil origins,presently,the hot debate on the oil origins needs to be clarified.In this paper,due to the selective consumption of different types of compounds in crude oils by severe and intense biodegradation,the commonly used oilsource correlation tools are ineffective or may produce misleading results,this study adopted a biomarker recovery method based on the principle of mass conservation that uses the sum of the mass of the residual biomarkers and their corresponding biodegradation products to obtain the mass of the original biomarkers,improving the reliability of oil origins determination.Based on the nature and occurrence of crude oils,the investigated oils are subdivided into three types,Group A,Group B and Group C.Group A,light oils occurred mainly in lower structure Neogene Shawan Formation in the western Chepaizi Uplift,while Group B,heavy oils occurred mainly in higher structure Neogene Shawan Formation in the western Chepaizi Uplift.The two types of crude oils may come from the mixed source of Jurassic Badaowan Formation source rocks(J_(1)b)and Paleogene Anjihaihe Formation source rocks(E_(2-3)a)in the Sikeshu Sag,and Jurassic Badaowan Formation source rocks(J_(1)b)are the main source of crude oils.Group C,heavy oils occurred mainly in Neogene Shawan Formation in the eastern Chepaizi Uplift,showing good correlation with the Permian(P_(1)f and P_(2)w)source rocks in the Shawan Sag.At the same time,by combining stable carbon isotope and parameters related to triaromatic steroids,the accuracy of the oilsource correlation results by biomarker recovery method was further verified.展开更多
基金supported by the Key Laboratory of Clinical Evaluation Technology for Human Experience with Chinese Medicine,Science and Technology Innovation Project of Guangdong Provincial Medical Products Administration(2022ZDB06)the Jointly Funded Project by Guangzhou Science and Technology Bureau,Research Institutes and Enterprises(2024A03j0355)+1 种基金the State Key Laboratory of Traditional Chinese Medicine Syndrome"Unveiling the List and Taking on Leadership"Project(SKLKY2025C0013)the National Key Research and Development Program of China(2025YFC3507902).
文摘The development of pattern-based traditional Chinese medicine(TCM)compound preparations constitutes a core domain that represents the principle of pattern differentiation-based treatment,a hallmark of TCM.However,the field has long been constrained by scientific and regulatory challenges in animal modeling,efficacy evaluation,and clinical positioning.This article proposes a new research and development(R&D)paradigm strategically based on human use experience(HUE)and centered on the patient as the key to overcoming these bottlenecks and achieving high-quality progress.We systematically dissect the traditional problems in this field and demonstrate the pivotal role of high-quality HUE in enabling precise clinical positioning and optimizing R&D pathways(e.g.,applying for exemptions from non-clinical studies).HUE guides the implementation of the“pattern-symptom integration”model.Furthermore,we detail the implementation of the patient-centered concept throughout the process of clinical trial design,collection of patients’experience data,clinical outcome assessment,and benefit-risk assessment.The integrative application of artificial intelligence in the R&D of pattern-based TCM drugs is also specifically explored.By synthesizing the“TCM theory,HUE,and clinical trials”evidence system,this article aims to provide a systematic strategic framework for establishing an R&D pathway that adheres to the intrinsic principles of TCM while simultaneously meeting modern scientific standards.
基金Project supported by the Key R&D Projects in Hunan Province(2021SK2047,2022NK2044)Science and Technology Innovation Program of Hunan Province(2022WZ1022)Superior Youth Project of the Science Research Project of Hunan Provincial Department of Education(22B0211)。
文摘The technology of solid-state lighting has developed for decades in various industries.Phosphor,as an element part,determines the application domain of lighting products.For instance,blue and redemitting phosphors are required in the process of plant supplementing light,arrow-band emitting phosphors are applied to backlight displays,etc.In this work,a Bi^(3+)-activated blue phosphor was obtained in a symmetrical and co mpact crystal structure of Gd3Sb07(GSO).Then,the co-doping strategy of alkali metal ions(Li^(+),Na^(+),and K^(+))was used to optimize the performance.The result shows that the photoluminescence intensity is increased by 2.1 times and 1.3 times respectively by introducing Li~+and K^(+)ions.Not only that,it also achieves narrow-band emitting with the full width of half-maximum(FWHM)reaching 42 nm through Na^(+)doping,and its excitation peak position also shifts from 322 to 375 nm,which can be well excited by near-ultraviolet(NUV)light emitting diode(LED)chips(365 nm).Meanwhile,the electroluminescence spectrum of GSO:0.6 mol%Bi^(3+),3 wt%Na^(+)matches up to 93.39%of the blue part of the absorption spectrum of chlorophyll a.In summary,the Bi^(3+)-activated blue phosphor reported in this work can synchronously meet the requirements of plant light replenishment and field emission displays.
基金the National Natural Science Foundation of China:Biomechanical Mechanism of Tendon Off-position and Joint Subluxation and Manual Treatment for Adolescent Neck Pain(No.82374467)the Research on the Mechanism of Manipulation to Regulate Internalizing Integrin and its Downstream Focal Adhesion Kinase/Ras Homolog Gene Family Member A/Rho-associated Coiled-coil Containing Protein Kinase 1 Signaling Pathway to Repair Chronic Skeletal Muscle Injury(No.82374481)the Mechanism of Huaizhen Nourishing the Liver Capsule to Maintain the Balance of Knee Joint from the Coupling and Interaction of Skeletal Muscle-subchondral Bone Dynamics Rresponse(No.81704103)。
文摘OBJECTIVE:To confirm the effectiveness and safety of Shi's manipulation in treating acute and subacute neck pain patients.METHODS:This multicenter,positive controlled,randomized clinical trial has trial and control groups.There were 240 patients randomly assigned to the trial group and the control group,and both groups received their respective intervention treatment methods for a period of 12 weeks.The time windows for clinical data collection were before treatment,immediately after treatment,3-d 1,2,4,8,and 12-week after treatment,and follow-up was conducted at 26 and 52-week after treatment.The observed indicators used include primary outcome index and secondary outcome index,with the primary outcome index being the assessment of neck pain severity,which is evaluated by patients using Numerical Rating Scale(NRS).Secondary secondary outcome index include,(a)cervical dysfunction index,measured by patients using the Neck Disability Index(NDI)for self-assessment;(b)Cervical activity measurement,measured through the cervical range of motion measurement program on Android mobile system;(c)Satisfaction treatment assessment,determined by the patient's self-evaluation;(d)Safety index,recorded the incidence of adverse reactions and adverse event.Results:The results showed that these efficacy indices were improved in different degrees in both groups.At immediate after intervention,there was significant difference in NRS,NDI,Cervical Range of Motion(ROM)between the two groups(P<0.01),the trial group was superior to the control group.At 3-d after intervention,there was significant difference in NRS,NDI,ROM between the two groups(P<0.01).At 1-week and 2-week after intervention,there was significant difference in NDI and ROM between the two groups(P<0.01).At 4-week and 6-week after intervention,there was significant difference in NDI,ROM between the two groups(P<0.05).At 8-week after intervention,there was significant difference in NDI,lateral-bending and axial-rotation ROM between the two groups(P<0.05).At 12-week after intervention,there was significant difference in NDI between the two groups(P<0.01).At 26-week and 52-week after intervention,there was significant difference in NDI,NRS between the two groups(P<0.01).In addition,the adverse reaction of trial group is significantly lower than that of control group(P<0.05).The satisfaction of patients in the trial group was better than that in the control group(P<0.01).CONCLUSION:Our findings suggest that Shi's manipulation can be a good complementary treatment option in patients with acute and subacute neck pain.
基金supported and funded by the National Natural Science Foundation of China(82101079)the Key R&D Program of Jiangsu Province(BE2023836)the National Key Research and Development Program of China(SQ2023YFC2400025).
文摘As the integration of medical big data and artificial intelligence advances,the secure sharing of medical data has become a key driving force for advancing disease research and clinical diagnosis.Federated learning,a distributed approach enabling collaborative data processing without sharing raw data,offers promising solutions to challenges in multi-center medical data sharing.This review summarizes the progress of federated learning in multi-center medical data processing,analyzed from four perspectives:system architectures,data distribution strategies,clinical tasks,and algorithmic models.At the same time,this paper explores the challenges in practical applications,such as data heterogeneity,communication overhead,and privacy concerns.It proposes driving future research development by optimizing algorithms,strengthening privacy protection mechanisms,and enhancing computational efficiency.
基金supported by the National Natural Science Foundation of China(Grant Nos.NSFC 82273405,and 81972306)supported partly by the Guangxi Nature Sciences grants(Grant No.2018GXNSFAA138028)the Guangxi Medical University Training Program for Distinguished Young Scholars.
文摘Objective:Hyper-progression recurrence(HPR)after hepatectomy is a specific recurrence pattern associated with extremely poor prognosis in patients with hepatocellular carcinoma(HCC).This study was aimed at investigating the probable risk factors and establishing comprehensive models for formulating clinical strategies.Methods:Overall,16,158 patients with HCC from 8 hospitals were screened,among whom 3,125 patients who underwent R0 resection were included,and divided into development(n=2,113)and validation(n=1,012)cohorts.A comprehensive study of HPR predictive models and biological features was conducted.Results:Among the 3,125 enrolled patients,506(16.19%)developed HPR.The influence of HPR on extremely poor prognosis was reflected by recurrence features,adverse effects on systemic and liver function,and limited therapeutic options.Nine variables closely associated with HPR were identified,and incorporated into nomogram and conditional inference tree models,which successfully achieved pre-and post-operative HPR risk stratification and facilitated clinical decision-making.Multi-dimensional verification also confirmed the predictive accuracy of model combinations and their reliability in clinical applications.Furthermore,biological analyses revealed that HCCs with HPR exhibited hyperactive biological processes,inactive metabolism,and immune exhaustion features,together with high MYCN/HMGA2 co-expression,thereby enhancing understanding of the molecular events leading to HPR and providing valuable knowledge for HPR management.Conclusions:HPR after hepatectomy is associated with extremely poor prognosis and requires substantial attention.We constructed comprehensive predictive models and propose a clinical strategy for guiding HPR prevention and management.
基金supported by the National Natural Science Foundation of China(32271580,42020104009)the Fundamental Research Funds for Zhejiang Provincial Universities and Research Institutes(JX6311101923)。
文摘Mytilus contain abundant antimicrobial peptides(AMPs)that play a key role in the innate immunity.However,heterologous production of these AMPs remains challenging due to their short sequences,multiple disulfide bonds,and high content of cationic amino acids,which hinder functional expression in prokaryotic systems such as Escherichia coli.To establish a eukaryotic recombinant expression system for the AMPs of mussel and obtain recombinant mussel AMPs for subsequent studies,we reported the successful recombinant expression of myticofensin B1,a novel defensin-like AMP identified previously in Mytiluscoruscus,using the eukaryotic host Pichia pastoris.The codon-optimized gene encoding the mature myticofensin-B1(composed of 65 amino acid residues,including 6 conserved cysteine residues)was cloned into a pPICZαA vector and expressed in P.pastoris GS115.Structural fidelity of the recombinant peptide was confirmed by liquid chromatography-tandem mass spectrometry(LC-MS/MS),showing a molecular weight of 8849.9 Da,which was consistent with the theoretical prediction.Functional assays demonstrated a broad-spectrum antimicrobial activity of the recombinant myticofensin-B1,with stronger inhibition against Gram-negative bacteria.Scanning electron microscopy revealed different effects of the recombinant myticofensin-B1 against different bacteria.In addition,the recombinant myticofensin-B1 exhibited a very low hemolytic activity against sheep red blood cells and weak cytotoxicity against human A549 lung cancer cells.This study establishes P.pastoris as a powerful platform to produce functional mussel AMP and highlights the potential of the recombinant myticofensin-B1 as a therapeutic agent for aquaculture pathogens and infections.
基金partly supported by the Yan’an University Qin Chuanyuan“Scientist+Engineer”Team Special Fund,No.2023KXJ-012(to YL)Yan’an University Transformation of Scientific and Technological Achievements Fund,No.2023CGZH-001(to YL)+2 种基金College Students Innovation and Entrepreneurship Training Program,Nos.D2023158,202410719056(to XS,JM)Yan’an University Production and Cultivation Project,No.CXY202001(to YL)Kweichow Moutai Hospital Research and Talent Development Fund Project,No.MTyk2022-25(to XO)。
文摘The cure rate for chronic neurodegenerative diseases remains low,creating an urgent need for improved intervention methods.Recent studies have shown that enhancing mitochondrial function can mitigate the effects of these diseases.This paper comprehensively reviews the relationship between mitochondrial dysfunction and chronic neurodegenerative diseases,aiming to uncover the potential use of targeted mitochondrial interventions as viable therapeutic options.We detail five targeted mitochondrial intervention strategies for chronic neurodegenerative diseases that act by promoting mitophagy,inhibiting mitochondrial fission,enhancing mitochondrial biogenesis,applying mitochondria-targeting antioxidants,and transplanting mitochondria.Each method has unique advantages and potential limitations,making them suitable for various therapeutic situations.Therapies that promote mitophagy or inhibit mitochondrial fission could be particularly effective in slowing disease progression,especially in the early stages.In contrast,those that enhance mitochondrial biogenesis and apply mitochondria-targeting antioxidants may offer great benefits during the middle stages of the disease by improving cellular antioxidant capacity and energy metabolism.Mitochondrial transplantation,while still experimental,holds great promise for restoring the function of damaged cells.Future research should focus on exploring the mechanisms and effects of these intervention strategies,particularly regarding their safety and efficacy in clinical settings.Additionally,the development of innovative mitochondria-targeting approaches,such as gene editing and nanotechnology,may provide new solutions for treating chronic neurodegenerative diseases.Implementing combined therapeutic strategies that integrate multiple intervention methods could also enhance treatment outcomes.
基金Tianjin Municipal Natural Science Foundation(23JCYBJC00040)National Natural Science Foundation of China(52175369)。
文摘The TiB+TiC dual-reinforced B_(4)C/TC4 composite was in-situ fabricated via incorporating 0.5wt%B_(4)C reinforcement during the laser melting deposition process.Different heat treatments of annealing and solid solution were used to regulate the microstructure,mechanical properties,and corrosion properties of B_(4)C/TC4 composite.Results show that with the increase in temperature from 500℃to 800°C,partial lamellarα-Ti in the as-deposited sample is gradually transformed into equiaxedα-Ti,accompanied by the disappearance of basketweave microstructure.At 1100°C,a small portion of TiC phase suffers fusion.This composite exhibits the optimal combination of strength and plasticity after annealing at 500℃for 4 h followed by furnace cooling,which is attributed to the stress release effect and the refined basketweave microstructure.However,this composite shows a decline in corrosion resistance after various heat treatments due to grain coarsening and micro-galvanic corrosion.
文摘In this study,a multifunctional aptamer-conjugated magnetic covalent organic framework(COF)-CuO/Au nanozyme(MCOF-CuO/Au@apt)was developed as a“three-in-one”platform for dual-signal colorimetric and fluorescent detection of Vibrio parahaemolyticus.The nanozyme integrated magnetic separation,peroxidase-like catalytic activity,and specific target recognition through an aptamer-based strategy.Upon binding to V.parahaemolyticus,the catalytic oxidation of tetra-aminophenylethylene(TPE-4A)by the nanozyme was selectively inhibited,resulting in distinct colorimetric and fluorescent signals that significantly enhanced the detection accuracy and reliability.The proposed method exhibited high sensitivity,with limits of detection(LOD)of 21 and 7 CFU/mL for the colorimetric and fluorescent assays,respectively.The performance of this method was validated using real seafood samples,including Penaeus vannamei,Mytilus coruscus,and Crassostrea gigas,which showed high recovery rates(101.11%-107.30%)and excellent reproducibility.The system also demonstrated strong specificity and accuracy under various conditions,confirming its robustness and practical applicability.Collectively,this innovative platform presents a promising solution for the rapid,versatile,and sensitive detection of V.parahaemolyticus in seafood,with considerable potential to advance food safety diagnosis and on-site monitoring.
文摘This study investigates the reduction in polarization measurement accuracy caused by varying in-cident angles in a liquid crystal variable retarder(LCVR).The phase delay characteristics of the LCVR were examined,with particular emphasis on the influence of different two-dimensional incident angles on phase delay behavior.Building upon the calibration of phase delay under normal incidence,a phase delay calibra-tion model was developed to account for variations in incident angle and driving voltage.A mathematical re-lationship was established between phase delay and the azimuth angle(α)and pitch angle(β).Experimental validation was conducted under three conditions:α=20°,β=0°;α=0°,β=20°;and an arbitrary angle whereα=5°,β=15°.The results demonstrated that the maximum average deviation between theoretical pre-dictions and experimental measurements did not exceed 0.059 rad.The proposed calibration method proved to be both accurate and practical.This approach offers robust support for LCVR parameter calibration and performance optimization in optical systems,particularly in polarization imaging applications.
文摘Three copper(Ⅱ),nickel and cadmium(Ⅱ)complexes,namely[Cu_(2)(μ-H2dbda)2(phen)2]·2H_(2)O(1),[Ni(μ-H2dbda)(μ-bpb)(H_(2)O)2]n(2),and[Cd(μ-H2dbda)(μ-bpa)]n(3),have been constructed hydrothermally using H4dbda(4,4'-dihydroxy-[1,1'-biphenyl]-3,3'-dicarboxylic acid),phen(1,10-phenanthroline),bpb(1,4-bis(pyrid-4-yl)benzene),bpa(bis(4-pyridyl)amine),and copper,nickel and cadmium chlorides at 160℃.The products were isolated as stable crystalline solids and were characterized by IR spectra,elemental analyses,thermogravimetric analyses,and singlecrystal X-ray diffraction analyses.Single-crystal X-ray diffraction analyses revealed that three complexes crystallize in the monoclinic P21/n,tetragonal I42d,and orthorhombic P21212 space groups.The complexes exhibit molecular dimers(1)or 2D metal-organic networks(2 and 3).The catalytic performances in the Knoevenagel reaction of these complexes were investigated.Complex 1 exhibits an effective catalytic activity and excellent reusability as a heterogeneous catalyst in the Knoevenagel reaction at room temperature.CCDC:2463800,1;2463801,2;2463802,3.
基金Key-Area Research and Development Program of Guangdong Province(2023B0909020004)Project of Innovation Research Team in Zhongshan(CXTD2023006)+1 种基金Natural Science Foundation of Guangdong Province(2023A1515011573)Zhongshan Social Welfare Science and Technology Research Project(2024B2022)。
文摘Laser powder bed fusion(LPBF)is highly suitable for forming 18Ni300 mold steel,thanks to its excellent capability in manufacturing complex shapes and outstanding capacity for regulating microstructures.It is widely used in fields such as injection molding,die casting,and stamping dies.Adding reinforcing particles into steel is an effective means to improve its performance.Nb/18Ni300 composites were fabricated by LPBF using two kinds of Nb powders with different particle sizes,and their microstructures and properties were studied.The results show that the unmelted Nb particles are uniformly distributed in the 18Ni300 matrix and the grains are refined,which is particularly pronounced with fine Nb particles.In addition,element diffusion occurs between the particles and the matrix.The main phases of the base alloy are α-Fe and a small amount of γ-Fe.With the addition of Nb,part of the α-Fe is transformed into γ-Fe,and unmelted Nb phases appear.The addition of Nb also enhances the hardness and wear resistance of the composites but slightly reduces their tensile properties.After aging treatment,the molten pools and grain boundaries become blurred,grains are further refined,and the interfaces around the particles are thinned.The aging treatment also promotes the formation of reverted austenite.The hardness,ultimate tensile strength,and volumetric wear rate of the base alloy reach 51.9 HRC,1704 MPa,and 17.8×10^(-6) mm^(3)/(N·m),respectively.In contrast,the sample added with fine Nb particles has the highest hardness(56.1 HRC),ultimate tensile strength(1892 MPa)and yield strength(1842 MPa),and the volume wear rate of the sample added with coarse Nb particles is reduced by 90%to 1.7×10^(-6) mm^(3)/(N·m).
基金funded by the Science and Technology Research and Development Program Project of China Railway Group Co.,Ltd,grant number P2024X002the China Academy of Railway Sciences Corporation Limited,grant number 2024YJ154.
文摘Purpose-This study investigates the impact of flagship trains on high-speed railway capacity utilization and develops a brand value-oriented optimization framework that balances service quality enhancement with operational efficiency.Design/methodology/approach-A mathematical optimization model based on integer programming is developed,incorporating flagship train constraints into capacity optimization.Case studies compare scenarios with and without flagship train considerations using the Beijing-Shanghai High-Speed Railway data across 20 experimental groups.Findings-Operating flagship trains with hourly departure constraints results in an average decrease of 0.9 trains and an 8.4%reduction in capacity utilization rate.When scheduling 2 flagship trains within a 2-h timeframe,capacity utilization decreases from 86.43%to 83.73%,quantifying the trade-off between brand positioning and operational capacity.Originality/value-This research provides the first quantitative framework for brand value-oriented railway capacity optimization,establishing clear definitions for flagship trains and mathematical foundations for evaluating service quality versus efficiency trade-offs.The findings offer practical decision support for railway operators balancing competitive positioning with capacity maximization.
文摘[Objectives]To provide a reference for the efficient use of wild Paeonia suffruticosa germplasm resources and the scientific selection of parents.[Methods]This study systematically evaluated cross-compatibility by conducting interspecific crosses among the major wild species subsect.Delavayanae(Paeonia delavayi,Paeonia lutea,Paeonia potaninii,and Paeonia ludlowii)as well as reciprocal crosses between these species and cultivated varieties from the subsect.Vaginatae.[Results]Crosses among P.delavayi,P.lutea,and P.potaninii generally exhibited good seed set,with the resulting seeds showing a high emergence rate.In contrast,crosses involving P.ludlowii as a parent produced only a limited number of seeds,none of which germinated.In crosses with cultivated varieties where the wild species served as the maternal parent,the average seed set ranked as follows:P.lutea>P.delavayi>P.ludlowii>P.potaninii.When wild species were used as paternal parent,the average seed set ranked as follows:P.potaninii>P.lutea>P.delavayi>P.ludlowii.On the whole,most crosses between wild species of subsect.Delavayanae and cultivated varieties achieved normal seed set,demonstrating a certain degree of cross-compatibility.However,when the wild species served as the maternal parent,both the seed set and seedling emergence rate were superior to those in the reciprocal crosses(with wild species as the paternal parent).[Conclusions]Significant differences in cross-compatibility were observed among species within Paeonia subsect.Delavayanae.In addition,a significant maternal effect was identified in crosses between wild species of this subsection and cultivated varieties.These findings suggest that by selecting highly compatible combinations,there remains considerable potential for utilizing these wild species in peony breeding.
基金supported by the National Natural Science Foundation of China(62271247)the Natural Science Foundation of Jiangsu Province(BK20240181)+4 种基金the Dreams Foundation of Jianghuai Advance Technology Center(2023-ZM01D001)the National Aerospace Science Foundation of China(20220055052001)the Qing Lan Project of Jiangsu Provincethe Fund of Prospective Layout of Scientific Research for Nanjing University of Aeronautics and Astronauticsthe Key Laboratory of Radar Imaging and Microwave Photonics(Nanjing University of Aeronautics and Astronautics),Ministry of Education。
文摘In this paper,the joint design of transmit and receive beamformers for transmit subaperturing multiple-input-multiple-output(TS-MIMO)radar is investigated,aiming to enhance its low probability of intercept(LPI)capability.The main objective is to simultaneously minimize the transmission power,suppress the transmit sidelobe levels,and minimize the probability of intercept,thus bolstering the LPI performance of the radar system while maintaining the desired target detection performance.An alternative optimization method is proposed to jointly optimize the transmit and receive beamformers,yielding an unified LPI optimization framework.Particularly,the proposed iterative algorithm based on the Lagrange duality theory for transmit beamforming is more efficient than the conventional convex optimization method.Numerical experiments highlight the effectiveness of the proposed approach in sidelobe suppression and computational efficiency.
文摘Shallow landslides are strongly controlled by near-surface lithological variability,yet conventional geological maps are often too generalized to support accurate susceptibility assessment in complex terrains.This review synthesizes recent advances in remote sensing–based lithological mapping and evaluates their integration into landslide susceptibility modeling.Evidence from the literature indicates that remote sensing-derived lithological products,particularly those incorporating mineralogical information and higher spatial resolution,consistently outperform traditional geological maps in improving model accuracy and spatial detail,especially in heterogeneous environments.However,key challenges remain,including scale mismatches between surface observations and subsurface controls,limited ground validation,uncertainty propagation,and restricted model transferability across regions.The review identifies multi-sensor data fusion and explainable machine learning as the most promising directions for advancing lithological discrimination and model reliability.Future progress depends on integrating remote sensing with process-based understanding,improving validation strategies,and standardizing uncertainty reporting.These developments are essential for enabling more robust,scalable,and operationally relevant landslide susceptibility assessments in complex terrains.Lastly,we describe the directions of research that focus on multi-sensor fusion,explainable machine learning,UAV(Unmanned Aerial Vehicle)-enabled validation,and standardized uncertainty reporting that can help articulate landslide susceptibility assessment,making them even more robust and operationally significant.
基金Supported by the National Natural Science Foundation of China(22378181).
文摘The development of materials with excellent microwave absorption(MWA)and electromagnetic interference(EMI)shielding performances has currently received attention.Herein,mesophase pitch-based carbon foam(MPCF)with 3D interconnected pore structure was prepared through the high pressure pyrolysis of mesophase coal tar pitch.It is found that the 3D interconnected cellular pores of MPCF facilitate multiple reflections of electromagnetic waves,which results in the minimum reflection loss(RLmin)value of MPCF reaches-37.84 dB with the effective absorption bandwidth(EAB)of 5.44 GHz at a thickness of 2.70 mm,and the total average electromagnetic shielding effectiveness(SE_(T))under 3.00 mm thickness achieves 26.52 dB in X-band.Subsequently,MPCF is activated by KOH to obtain activated carbon foam(A-MPCF).The average SE_(T)of A-MPCF achieves 103.00 dB for abundant nanopores on the pore cell walls,which leads to a transition from the multiple reflections of electromagnetic waves on the walls to diffuse reflection.Unfortunately,the reflection coefficient(R)of A-MPCF increases from 0.78 to 0.90.To reduce the R value,Fe_(3)O_(4)/A-MPCF was fabricated via the in situ growth of nano Fe_(3)O_(4)on A-MPCF.Consequently,the R value of Fe_(3)O_(4)/A-MPCF was reduced from 0.90 to 0.74,whereas the MWA performance was only slightly decreased.This work proposes a simple strategy for simultaneously adjusting MWA and EMI shielding performances of materials.
基金Supported by Open Fund Project of the Engineering Technology Research Center of Characteristic Medicinal Plants of Fujian(PP202003).
文摘This paper provides a systematic review of the histochemical localization,content characteristics,and influencing factors of saponins in Pseudostellaria heterophylla based on an extensive literature survey.It provides an in-depth analysis and summary of the effects of biological factors,environmental conditions,agronomic practices,processing methods,and continuous cropping obstacles on the synthesis of P.heterophylla saponins,as well as their underlying mechanisms.Based on identified gaps in the current literature,future research directions and prospects are proposed.The findings of this review offer valuable insights for advancing the understanding of the saponin biosynthesis mechanisms in P.heterophylla and for enhancing its quality.
基金supported by the Science and Technology Innovation Program of Hunan Province(Nos.2023RC1025 and 2024RC3022)the Technology Special Program Project of China Minmetals Corporation(No.2021ZXA04)the Major Scientific Research Projects of Inner Mongolia Baotou Steel Union Co.,Ltd.(No.HKF202300356).
文摘High-sulfur iron concentrates emit SO_(2)into the flue gas during pellet induration.To investigate the effect of the SO_(2)cycle on pellet quality in the grate-kiln process,sulfur balance analysis,thermodynamic calculations,and pellet production experiments under simulated flue gas circulation conditions were conducted.The results indicated that SO_(2)circulation inhibited desulfurization and deteriorated pellet strength.SO_(2)absorption increased the pellet sulfur content to 0.70 wt.%during the downdraft drying phase,and the absorption could be aggravated by the moisture.The desulfurization rate of the preheating process was also decreased to 16.67%,resulting from the refractory sulfate generation.Sulfur content of the roasted pellets dropped to 0.13 wt.%because of the aluminosilicate generation.The finished pellet sulfur content further decreased to 0.08 wt.%due to the fresh air during the cooling process.Eventually,optimization measures were proposed when high-sulfur iron concentrates were used for oxidized pellet preparation.
基金co-funded by the National Natural Science Foundation of China(42372160,42072172)。
文摘The Neogene Shawan Formation in the Chepaizi Uplift of the Junggar Basin(NW China)has obtained high oil flow,demonstrating a good potential for oil and gas exploration.The multi-source hydrocarbon generation background and strong tectonic activity have led to the simultaneous production of heavy oil and light oil from multi-layer in the area,which makes it very difficult to identify oil origins,presently,the hot debate on the oil origins needs to be clarified.In this paper,due to the selective consumption of different types of compounds in crude oils by severe and intense biodegradation,the commonly used oilsource correlation tools are ineffective or may produce misleading results,this study adopted a biomarker recovery method based on the principle of mass conservation that uses the sum of the mass of the residual biomarkers and their corresponding biodegradation products to obtain the mass of the original biomarkers,improving the reliability of oil origins determination.Based on the nature and occurrence of crude oils,the investigated oils are subdivided into three types,Group A,Group B and Group C.Group A,light oils occurred mainly in lower structure Neogene Shawan Formation in the western Chepaizi Uplift,while Group B,heavy oils occurred mainly in higher structure Neogene Shawan Formation in the western Chepaizi Uplift.The two types of crude oils may come from the mixed source of Jurassic Badaowan Formation source rocks(J_(1)b)and Paleogene Anjihaihe Formation source rocks(E_(2-3)a)in the Sikeshu Sag,and Jurassic Badaowan Formation source rocks(J_(1)b)are the main source of crude oils.Group C,heavy oils occurred mainly in Neogene Shawan Formation in the eastern Chepaizi Uplift,showing good correlation with the Permian(P_(1)f and P_(2)w)source rocks in the Shawan Sag.At the same time,by combining stable carbon isotope and parameters related to triaromatic steroids,the accuracy of the oilsource correlation results by biomarker recovery method was further verified.
