This study draws on the classic theories and research achievements of university teacher development,and from the perspective of role conflict in social psychology,proposes policy recommendations for the development o...This study draws on the classic theories and research achievements of university teacher development,and from the perspective of role conflict in social psychology,proposes policy recommendations for the development of clinical teachers in medical colleges,including following different stages of teacher development and designing teaching development strategies at different levels;designing the content and form of teaching development activities to meet the temporal and spatial needs of clinical teachers;and building an academic community for clinical teachers to promote the creation of teaching development behaviors.展开更多
With the continuous expansion of medical student enrollment,the number of clinical teaching bases is gradually increasing.However,there are significant differences in clinical teaching management models and teaching l...With the continuous expansion of medical student enrollment,the number of clinical teaching bases is gradually increasing.However,there are significant differences in clinical teaching management models and teaching levels among different bases.Most clinical teaching bases have incomplete teaching management systems,inadequate teaching management institutions,insufficient teaching personnel,and inadequate implementation of teaching rules and regulations.This article combines the construction practice of three-level clinical teaching base of the General Medicine College and the First Affiliated Hospital of Xi’an Medical University.We establish a standardized management system for the three-level clinical teaching base;implement a teaching supervision system and strengthen the monitoring of teaching quality;adopt multiple evaluations to test the effectiveness of clinical teaching implementation;explore the path of homogenization construction of teaching bases in terms of unified teacher training,promoting the development of teacher teaching abilities with equal quality and excellence,and providing a reference for improving the quality of medical talent training.展开更多
Energy is the bedrock of national economic development and a vital pillar for achieving sustainable growth.High-quality energy cooperation is critical to ensuring sustained,stable national economic development and the...Energy is the bedrock of national economic development and a vital pillar for achieving sustainable growth.High-quality energy cooperation is critical to ensuring sustained,stable national economic development and the transformation of the energy sector.Based on the achievements of high-quality energy cooperation within the Belt and Road Initiative,this paper systematically analyzes the current state of energy cooperation under the Belt and Road Initiative.In accordance with the intrinsic requirements for high-quality energy cooperation,and building upon the analysis and summary of prior research,this paper proposes strategies to promote high-quality energy cooperation within the Belt and Road Initiative:(1)Innovating cooperative concepts and optimizing the cooperative environment;(2)Innovating cooperation modes and expanding the scope of cooperation;(3)Improving the cooperation mechanism and building a multi-level cooperation platform;(4)Strengthening cultural exchanges and promoting dialogue.This paper offers insights and support for fostering high-quality collaboration within the Belt and Road Initiative and enhancing international energy cooperation.展开更多
Objective:To evaluate the predictive value of secreted phosphoprotein 1(SPP1)gene expression for postoperative survival in patients with advanced liver cancer undergoing hepatic artery interventional chemoembolization...Objective:To evaluate the predictive value of secreted phosphoprotein 1(SPP1)gene expression for postoperative survival in patients with advanced liver cancer undergoing hepatic artery interventional chemoembolization treatment.Method:Bioinformatics methods,including gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis,were used to identify genes related to survival prognosis in hepatocellular carcinoma(HCC)patients.A retrospective analysis of 115 advanced liver cancer patients treated between January 2016 and October 2017 was conducted.Patients were categorized into SPP1 high-expression(n=89)and low-expression groups(n=26).Additionally,115 healthy individuals served as the control group.The relationship between SPP1 expression and clinical pathological features was analyzed.A 60-month follow-up and logistic regression analysis identified risk factors affecting survival.Results:SPP1 mRNA expression was significantly higher in liver cancer patients compared to healthy controls(P<0.05).SPP1 expression levels were significantly associated with tumor size,Child-Pugh grading,lymph node metastasis,and BCLC staging(P<0.05).High SPP1 expression,along with tumor size,Child-Pugh grading,lymph node metastasis,and BCLC staging,were independent risk factors for survival(P<0.05).The 60-month survival rate was 17.39%,with a median survival of 40 months in the low-expression group versus 18 months in the high-expression group(P<0.05).Conclusion:SPP1 expression is significantly upregulated in advanced liver cancer patients and has predictive value for postoperative survival following hepatic artery chemoembolization treatment.SPP1,combined with clinical indicators such as tumor size,Child-Pugh grading,lymph node metastasis,and BCLC staging,may serve as a prognostic biomarker for interventional treatment outcomes.展开更多
The“New Medical Education”is a new requirement for the development of medical education in the new era.As a key and core element of the construction of the“New Medical Education,”the engagement in teaching work of...The“New Medical Education”is a new requirement for the development of medical education in the new era.As a key and core element of the construction of the“New Medical Education,”the engagement in teaching work of university teachers is a key issue that determines the level of teaching development of university teachers and affects the quality of talent cultivation in universities.Using the literature review method,this study analyzed 39 relevant literatures retrieved from China National Knowledge Infrastructure(CNKI)from 1997 to 2023.The concept,connotation,current situation,influencing factors,and improvement strategies of teaching engagement by university teachers were reviewed and summarized.The results showed that the issue of teaching engagement by university teachers has not received high attention in the field of higher education,especially in higher medical education,which has not yet been reported.Although the overall number of literature is not large,some of the conclusions have important implications for the next research on the influencing factors and mechanisms of double-qualified teacher engagement in higher medical colleges.展开更多
Objective:To build a set of teaching staff construction and teaching quality monitoring system suitable for clinical practice teaching in affiliated hospitals of medical colleges,achieve continuous improvement of clin...Objective:To build a set of teaching staff construction and teaching quality monitoring system suitable for clinical practice teaching in affiliated hospitals of medical colleges,achieve continuous improvement of clinical education and teaching level,and ensure the quality of medical education talent cultivation.Methods:A modern clinical practice teaching quality monitoring system is constructed based on organizational structure construction,teaching staff system construction,quality control system construction,and information platform construction,combined with external audit and evaluation.Results:The hospital has established a Faculty Development and Teaching Evaluation Office specifically responsible for the cultivation of clinical teachers and the evaluation and supervision of teaching quality.A relatively complete teacher construction and teaching quality monitoring system has also been established for clinical practice teaching,thus achieving integration with the school’s quality control system in terms of management mechanism.At the same time,a set of teaching quality control mode based on the“Internet+”platform has been created by means of informatization.At present,this mode has won three national computer software copyrights and two second prizes for school-level teaching achievements.Conclusion:Through five years of practice,an“Internet+”teaching quality evaluation and monitoring system with the characteristics of teaching hospitals affiliated to local medical colleges has been established.In order to further standardize the training system of clinical teachers in affiliated hospitals,achieve self-monitoring and self-improvement in terms of teaching quality,and ensure the continuous improvement of clinical teaching quality,we will continue to promote the development of clinical teachers with quality and excellence,enrich the main team of quality monitoring,guide the transformation of the education mode from being“centered on teachers”to being“centered on students,”and realize the integration of internal and external quality monitoring systems.展开更多
Roles of Marigold extracts (ME) on arsenic trioxide (ATO)-induced oxidative damage to pancreatic β-cells need to be further elucidated. In this study, NIT-1 cells were treated with different concentrations of and/or ...Roles of Marigold extracts (ME) on arsenic trioxide (ATO)-induced oxidative damage to pancreatic β-cells need to be further elucidated. In this study, NIT-1 cells were treated with different concentrations of and/or ATO, following by the cell viability was detected by CCK8 assay. Then, intracellular reactive oxygen species (ROS) levels, lipid peroxide (MDA) contents and superoxide dismutase (SOD) activity were measured with a fluorescence probe method and colorimetric assay, respectively. The apoptosis rate and morphology was detected and observed with hoechst 33,258 staining assay. The mRNA levels and protein expressions of nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were measured by real-time fluorescence quantitative polymerase chain reaction and protein immunoblotting assay, respectively. Our results indicated that Co-treatment with ME and ATO exacerbated the cell viability decreasing reduced by ATO, while the addition of ME after ATO treatment effectively promote the recovery of ATO reduced survival rates. The ATO group increased apoptosis (P P β-cells by modulating the activation of the Nrf2 signaling pathway.展开更多
Objective:This article aims to deeply analyze the feedback on teacher training in an affiliated hospital,so as to clarify the current needs and situation of teacher training and provide a scientific basis for further ...Objective:This article aims to deeply analyze the feedback on teacher training in an affiliated hospital,so as to clarify the current needs and situation of teacher training and provide a scientific basis for further optimizing the teacher training system.Methods:The current situation and needs of teacher training in the affiliated hospital were collected by designing and distributing Tomato Form questionnaires on the DingTalk platform.The questionnaire adopted a percent-point system,all of which were indeterminate multiple-choice questions.Results:The average age of the clinical teachers participating in the survey was 40.44±7.85 years old,with an average teaching length of 4–10 years.The results showed that 60.20%of teachers think that the amount of teacher training in an affiliated hospital is sufficient;91.10%of teachers think that the factors affecting training conflict with working hours;97.96%of teachers believe that the training time has an impact on the training effect;81.63%of teachers prefer online training;51.53%of teachers tend to arrange training time on working days;33.16%of teachers tend to train once a month;17.78%of teachers prefer to receive training on clinical theoretical courses and practical teaching norms and skills content.Conclusion:Based on the above survey results,we propose to build a comprehensive management mechanism for teacher training,including improving the access,training,and assessment mechanism for clinical teachers,and adjusting and optimizing the training program according to actual needs.At the same time,an effective communication platform should be built to promote the deep integration of teaching and practice and enhance social recognition,so as to comprehensively improve the teaching quality and medical service of the hospital.展开更多
With the continuous deepening of educational reform and the rapid development of higher education,as an important battlefield for knowledge dissemination,scientific research innovation,and social services,the financia...With the continuous deepening of educational reform and the rapid development of higher education,as an important battlefield for knowledge dissemination,scientific research innovation,and social services,the financial management level of universities directly affects the efficiency of resource allocation,improvement of teaching quality,and sustainable development ability of the school.However,in the context of rapid expansion and diversified development,financial management in universities faces many challenges and problems.If not solved,it will inevitably negatively impact the management of universities and restrict their development.This article aims to deeply analyze the main problems in current financial management in universities and propose corresponding countermeasures and suggestions,to provide reference for improving the efficiency of financial management in universities.展开更多
Hepatocellular carcinoma is prone to invasion and metastasis.It often receives a low diagnosis rate in the early stage but has an extremely high mortality rate.Epithelial-mesenchymal transformation(EMT)is a key factor...Hepatocellular carcinoma is prone to invasion and metastasis.It often receives a low diagnosis rate in the early stage but has an extremely high mortality rate.Epithelial-mesenchymal transformation(EMT)is a key factor in promoting tumor cell invasion and metastasis.Circular RNA(circRNA)is involved in regulating EMT in hepatocarcinoma cells through multiple pathways,thereby affecting the occurrence and progression of hepatocellular carcinoma.This article mainly reviews the research progress of circRNA related to EMT core transcription factors,circRNA that promotes EMT in liver cancer,and circRNA that inhibits EMT in liver cancer.展开更多
Taking role conflict as the starting point,this article examines and reflects on the development of clinical teachers.In the process of the occurrence,development,and resolution of role conflicts among clinical teache...Taking role conflict as the starting point,this article examines and reflects on the development of clinical teachers.In the process of the occurrence,development,and resolution of role conflicts among clinical teachers,there are many hidden issues related to the development of clinical teachers.The development of clinical teacher teaching and role conflict management contain similar educational philosophies and practical issues.This study draws on classic theories and research achievements in the development of university teachers and conducts theoretical analysis and practical reflection on the development of clinical teachers in medical colleges from the perspective of role conflict in social psychology.Policy recommendations are proposed,including strengthening the construction of teaching systems at the hospital organizational environment level,enhancing the role identity and teacher beliefs of clinical teachers,promoting their teaching development and academic learning,and ensuring their normal teaching investment;promoting leadership support at the level of interpersonal interaction and leveraging the role of colleague support in alleviating role conflicts;enhancing individual teacher beliefs,teacher role learning,and role skills.展开更多
OBJECTIVE: To analyze treatment effectiveness in terms of the medication injection site. METHODS: The medical records of 423 patients with cerebral palsy who were admitted to Maternal and Child Health Hospital between...OBJECTIVE: To analyze treatment effectiveness in terms of the medication injection site. METHODS: The medical records of 423 patients with cerebral palsy who were admitted to Maternal and Child Health Hospital between January 2009 and December 2016 were collected. All cases were divided into T1, T2, T3, and T4 groups based on the use of conventional medication sites and acupoints for administering injectable medicines. RESULTS: In the T1 group, patients received injections at conventional medication sites between 2009 and 2010. In the T2 group, patients received injections at conventional medication sites combined with acupoint injection therapy I from 2011 to 2012. In the T3 group, injection at conventional medication sites plus acupoint injection II was applied between 2013 and 2014. Acupoint injection only was used in the T4 group from 2015 to 2016. Therapeutic effects were statistically compared among the different injection procedures. The overall Gross Motor Function Measure (GMFM) and Fine Motor Function Measure (FMFM) scores were significantly improved after hospital discharge. The GMFM score was considerably higher in the T4 group than in the other groups (all P = 0.001 < 0.05). The GMFM scores were significantly higher in the T2 groups than in the T1 group (P = 0.001< 0.05), but no significant difference was observed between the other paired comparions (P > 0.05). Meanwhile, the FMFM scores were significantly higher in the T2 and T4 groups than in the T1 and T3 groups (all P = 0.001 < 0.05). Site injection therapy can significantly improve gross and fine motor function in children with cerebral palsy. CONCLUSION: It is feasible to administer injectable medicines at acupoints instead of convention sites to enhance the therapeutic effect of treatment in patients with cerebral palsy.展开更多
COVID-19 has changed the way of learning and life of college students.The purpose is to explore the relationship between perceived stress and anxiety,and the mediating effect of resilience and regulatory emotional sel...COVID-19 has changed the way of learning and life of college students.The purpose is to explore the relationship between perceived stress and anxiety,and the mediating effect of resilience and regulatory emotional self-efficacy in college students during COVID-19.309 students from three colleges were selected as research participants(average age 19.79±1.11 years).SPSS was used to measure the correlation between variables.Amos was used to test the path coefficient and mediating effect of the hypothetical model.The results show that:Firstly,perceived stress has a significantly and positively predictive effect on anxiety.Secondly,psychological resilience and regu-latory emotional self-efficacy independently played a significant and partially mediating effect between perceived stress and anxiety.Among them,perceived stress had a negative predictive effect on psychological resilience and regulatory emotional self-efficacy.Psychological resilience and regulatory emotional self-efficacy had a negative predictive effect on anxiety.Thirdly,psychological resilience and regulatory emotional self-efficacy play a chain mediation role between psychological stress and anxiety.Regulatory emotional self-efficacy cannot only directly predict the level of anxiety,but also indirectly predict the level of anxiety by regulating psychological resilience.This study reveals the relationship between college students’perceived stress and anxiety,and the mediating effect of psychological resilience and regulatory emotional self-efficacy in the new time of COVID-19.The chain mediation role of psychological resilience and regulatory emotional self-efficacy reminds college mental health educators that improving students’regulatory emotional self-efficacy is an important way to promote students’mental health.展开更多
General education has become more and more attention.The culture has a more long-term and lasting contribution,so more and more colleges and universities have adopted a series of reform measures.Effect of the practice...General education has become more and more attention.The culture has a more long-term and lasting contribution,so more and more colleges and universities have adopted a series of reform measures.Effect of the practice of general education,however,still cannot satisfactory.In this paper,main factors affecting was analyzed on the basis of extensive research and questionnaire data analysis and targeted put forward the optimization effect of general education.It is important to make every effort to make the general education in China to achieve"Phoenix Nirvana".展开更多
BACKGROUND It is evident that current clinical criteria are suboptimal to accurately estimate patient prognosis.Studies have identified epigenetic aberrant changes as novel prognostic factors for colorectal cancer(CRC...BACKGROUND It is evident that current clinical criteria are suboptimal to accurately estimate patient prognosis.Studies have identified epigenetic aberrant changes as novel prognostic factors for colorectal cancer(CRC).AIM To estimate whether a methylation gene panel in different clinical stages can reflect a different prognosis.METHODS We enrolled 120 CRC patients from Tri-Service General Hospital in Taiwan and used the candidate gene approach to select six genes involved in carcinogenesis pathways.Patients were divided into two groups based on the methylation status of the six evaluated genes,namely,the<3 aberrancy group and≥3 aberrancy group.Various tumor stages were divided into two subgroups(local and advanced stages)on the basis of the pathological type of the following tissues:Tumor and adjacent normal tissues(matched normal).We assessed DNA methylation in tumors and adjacent normal tissues from CRC patients and analyzed the association between DNA methylation with different cancer stages and the prognostic outcome including time to progression(TTP)and overall survival.RESULTS We observed a significantly increasing trend of hazard ratio as the number of hypermethylated genes increased both in normal tissue and tumor tissue.The 5-year TTP survival curves showed a significant difference between the≥3 aberrancy group and the<3 aberrancy group.Compared with the<3 aberrancy group,a significantly shorter TTP was observed in the≥3 aberrancy group.We further analyzed the interaction between CRC prognosis and different cancer stages(local and advanced)according to the methylation status of the selected genes in both types of tissues.There was a significantly shorter 5-year TTP for tumors at advanced stages with the promoter methylation status of selected genes than for those with local stages.We found an interaction between cancer stages and the promoter methylation status of selected genes in both types of tissues.CONCLUSION Our data provide a significant association between the methylation markers in normal tissues with advanced stage and prognosis of CRC.We recommend using these novel markers to assist in clinical decision-making.展开更多
Plastic film mulch in agricultural production becomes essential to maintaining crop yields in arid and semiarid areas.However,the presence of residual film in farmland soil has also drawn much attention.In this study,...Plastic film mulch in agricultural production becomes essential to maintaining crop yields in arid and semiarid areas.However,the presence of residual film in farmland soil has also drawn much attention.In this study,three experiments were conducted.The first two experimental designs included 0,450,1350,and 2700 kg ha^(-1) of residual film pieces of approximately 5 cm side length added to field soil(0-20 cm soil depth)for seven years and added to pots for four years.In the third experiment,1350 kg ha^(-1)of the residual film with different side lengths(2-5,5-10,10-15,and 15-20 cm)was added to field soil for six years to explore the effect of residual film fragment size on soil nutrients,soil microorganisms,crop growth and yields.The residual film had little effect on the soil moisture at a field depth of 0-2(or 0-1.8)m.There were no significant effects on organic carbon,total nitrogen,inorganic nitrogen,total phosphorus or available phosphorus in the 0-20 cm soil layer.The presence of residual film decreased the richness and diversity of the bacterial community of the surface soil of the residual film,but it had no significant effect on the microbial community of the non-surface soil.The emergence rates of wheat and lentils occasionally decreased significantly with different amounts of residue fragments added to the field.At 450-2700 kg ha^(-1),the residual film reduced the plant height and stem diameter of maize and significantly reduced the shoot biomass of harvested maize by 11-19%.The average yields of maize and potato over the seven years decreased,but there were almost no significant statistical differences among the treatments.These results provide important data for a comprehensive scientific understanding of the effects of residual film on soil and crops in dryland farming systems.展开更多
To achieve the production information management of the coning,drawing and twisting's workshop,and promote a good and fast development of the textile enterprise,firstly,we analyze the information technology develo...To achieve the production information management of the coning,drawing and twisting's workshop,and promote a good and fast development of the textile enterprise,firstly,we analyze the information technology development status of the textile enterprise at home and abroad,study the weaknesses of the existing computer monitoring system,introduce the system design project,and propose a system network model based on client/server(C/S)mode.Secondly,a multi-agent production monitoring and control system is developed,and the communication of the single-port-multi-protocol and a multi-thread data collection technology are studied via the multi-thread and standard template library(STL)technologies.Thirdly,the system management functions,the structure design of the database,and the technical difficulties in the process of software design are also introduced.As proved in practice,the system satisfies the production management requirements of the workshop,and implements the network management of the production information.展开更多
New open manufacturing environments have been proposed aiming at realizing more flexible distributed manufacturing paradigms,which can deal with not only dynamic changes in volume and variety of products,but also chan...New open manufacturing environments have been proposed aiming at realizing more flexible distributed manufacturing paradigms,which can deal with not only dynamic changes in volume and variety of products,but also changes of machining equipments,dispersals of processing locations,and also with unscheduled disruptions.This research is to develop an integrated process planning and scheduling system,which is suited to this open,dynamic,distributed manufacturing environment.Multi-agent system(MAS)approaches are used for integration of manufacturing processing planning and scheduling in an open distributed manufacturing environment,in which process planning can be adjusted dynamically and manufacturing resources can increase/decrease according to the requirements.One kind of multi-level dynamic negotiated approaches to process planning and scheduling is presented for the integration of manufacturing process planning and scheduling.展开更多
Cat on a Hot Tin Roof,written by Tennessee Williams in 1955,is a brilliant play about a dysfunctional family.In this play,Williams uses his craft to entertain,enlighten and bare men's soul in morden society.By ana...Cat on a Hot Tin Roof,written by Tennessee Williams in 1955,is a brilliant play about a dysfunctional family.In this play,Williams uses his craft to entertain,enlighten and bare men's soul in morden society.By analyzing its major characters,themes and symbols,this paper tries to show this play's contemporary significance.展开更多
Considering different contact situations of grains, we effective anisotropies of magnetically soft α-Fe grains, investigate the effects of exchange-coupling interaction on hard Nd2Fe14B grains and NdaFe14B/α-Fe nano...Considering different contact situations of grains, we effective anisotropies of magnetically soft α-Fe grains, investigate the effects of exchange-coupling interaction on hard Nd2Fe14B grains and NdaFe14B/α-Fe nanocomposite. An expression of effective anisotropy suitable for different degrees of exchange-coupling between grains is presented. The calculation results show that the exchange-coupling interaction increases the average anisotropy of soft grains and decreases that of hard grains. The effective anisotropy of Nd2Fe14B/α-Fe nanocomposite decreases smoothly with decreasing grain size when the grain size is larger than 20 nm while it decreases dramaticaily with further decrease of the grain size. In order to maintain high coercivity in Nd2Fe14B/α-Fe nanoeomposite, the grain size should not be less than 20nm.展开更多
基金2023 Shaanxi Teacher Development Research Program“Research on the Construction and Improvement Path of a Teaching Engagement Model for Double-Qualified Teachers in Medical Colleges”(Project number:2023JSQ011)。
文摘This study draws on the classic theories and research achievements of university teacher development,and from the perspective of role conflict in social psychology,proposes policy recommendations for the development of clinical teachers in medical colleges,including following different stages of teacher development and designing teaching development strategies at different levels;designing the content and form of teaching development activities to meet the temporal and spatial needs of clinical teachers;and building an academic community for clinical teachers to promote the creation of teaching development behaviors.
基金2022 Education and Teaching Reform Research Project of Xi’an Medical University“Construction and Practice of the Teaching Quality Assurance System in the Three-Level Teaching Base of General Practice Medicine Under the Internet+Model”(Project number:2022JG-05)。
文摘With the continuous expansion of medical student enrollment,the number of clinical teaching bases is gradually increasing.However,there are significant differences in clinical teaching management models and teaching levels among different bases.Most clinical teaching bases have incomplete teaching management systems,inadequate teaching management institutions,insufficient teaching personnel,and inadequate implementation of teaching rules and regulations.This article combines the construction practice of three-level clinical teaching base of the General Medicine College and the First Affiliated Hospital of Xi’an Medical University.We establish a standardized management system for the three-level clinical teaching base;implement a teaching supervision system and strengthen the monitoring of teaching quality;adopt multiple evaluations to test the effectiveness of clinical teaching implementation;explore the path of homogenization construction of teaching bases in terms of unified teacher training,promoting the development of teacher teaching abilities with equal quality and excellence,and providing a reference for improving the quality of medical talent training.
基金National Social Science Fund Western Project,“Promoting strategies and realization paths for high-quality energy cooperation under the Belt and Road Initiative”(Grant No.24XGJ002)。
文摘Energy is the bedrock of national economic development and a vital pillar for achieving sustainable growth.High-quality energy cooperation is critical to ensuring sustained,stable national economic development and the transformation of the energy sector.Based on the achievements of high-quality energy cooperation within the Belt and Road Initiative,this paper systematically analyzes the current state of energy cooperation under the Belt and Road Initiative.In accordance with the intrinsic requirements for high-quality energy cooperation,and building upon the analysis and summary of prior research,this paper proposes strategies to promote high-quality energy cooperation within the Belt and Road Initiative:(1)Innovating cooperative concepts and optimizing the cooperative environment;(2)Innovating cooperation modes and expanding the scope of cooperation;(3)Improving the cooperation mechanism and building a multi-level cooperation platform;(4)Strengthening cultural exchanges and promoting dialogue.This paper offers insights and support for fostering high-quality collaboration within the Belt and Road Initiative and enhancing international energy cooperation.
基金Medical Research Project of Xi’an Science and Technology Bureau“Molecular Mechanism of miR-1305 Competitive Endogenous circRNA in the Development of Liver Cancer”(Project No.22YXYJ0134)General Project of Key Research and Development Program of Shaanxi Provincial Department of Science and Technology“Mechanism Study on the Inhibition of Liver Cancer Invasion and Metastasis by Downregulating METTL3 and Reducing the m6A Modification Level of MMP3 with Honokiol”(Project No.2023-YBSF-631)。
文摘Objective:To evaluate the predictive value of secreted phosphoprotein 1(SPP1)gene expression for postoperative survival in patients with advanced liver cancer undergoing hepatic artery interventional chemoembolization treatment.Method:Bioinformatics methods,including gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis,were used to identify genes related to survival prognosis in hepatocellular carcinoma(HCC)patients.A retrospective analysis of 115 advanced liver cancer patients treated between January 2016 and October 2017 was conducted.Patients were categorized into SPP1 high-expression(n=89)and low-expression groups(n=26).Additionally,115 healthy individuals served as the control group.The relationship between SPP1 expression and clinical pathological features was analyzed.A 60-month follow-up and logistic regression analysis identified risk factors affecting survival.Results:SPP1 mRNA expression was significantly higher in liver cancer patients compared to healthy controls(P<0.05).SPP1 expression levels were significantly associated with tumor size,Child-Pugh grading,lymph node metastasis,and BCLC staging(P<0.05).High SPP1 expression,along with tumor size,Child-Pugh grading,lymph node metastasis,and BCLC staging,were independent risk factors for survival(P<0.05).The 60-month survival rate was 17.39%,with a median survival of 40 months in the low-expression group versus 18 months in the high-expression group(P<0.05).Conclusion:SPP1 expression is significantly upregulated in advanced liver cancer patients and has predictive value for postoperative survival following hepatic artery chemoembolization treatment.SPP1,combined with clinical indicators such as tumor size,Child-Pugh grading,lymph node metastasis,and BCLC staging,may serve as a prognostic biomarker for interventional treatment outcomes.
基金2022 Education and Teaching Reform Research Project of Xi’an Medical University,“Construction and Practice of Teaching Quality Assurance System in Three-Level Teaching Bases of General Practice Medicine Under the‘Internet+’Model”(Project number:2022JG-05)2021 Shaanxi Undergraduate and Higher Continuing Education Teaching Reform Research Project of Shaanxi Provincial Department of Education,“Construction of Teaching Staff Based on‘Online Learning Platform for Clinical Teachers of the First Affiliated Hospital of Xi’an Medical University’and Construction and Practice of Quality Assurance System”(Project number:21BZ066)。
文摘The“New Medical Education”is a new requirement for the development of medical education in the new era.As a key and core element of the construction of the“New Medical Education,”the engagement in teaching work of university teachers is a key issue that determines the level of teaching development of university teachers and affects the quality of talent cultivation in universities.Using the literature review method,this study analyzed 39 relevant literatures retrieved from China National Knowledge Infrastructure(CNKI)from 1997 to 2023.The concept,connotation,current situation,influencing factors,and improvement strategies of teaching engagement by university teachers were reviewed and summarized.The results showed that the issue of teaching engagement by university teachers has not received high attention in the field of higher education,especially in higher medical education,which has not yet been reported.Although the overall number of literature is not large,some of the conclusions have important implications for the next research on the influencing factors and mechanisms of double-qualified teacher engagement in higher medical colleges.
基金supported by the 2020 Education and Teaching Reform Research Project of Xi’an Medical University,“Construction of‘Double-Qualified’Teachers in Affiliated Hospitals Based on‘Online Learning Platform for Clinical Teachers’and Construction and Practice of Quality Assurance System”(Project Number:2020JG-02)the 2021 Shaanxi Undergraduate and Higher Continuing Education Teaching Reform Research Project of Shaanxi Provincial Department of Education,“Construction of Teaching Staff Based on‘Online Learning Platform for Clinical Teachers of the First Affiliated Hospital of Xi’an Medical University’and Construction and Practice of Quality Assurance System”(Project Number:21BZ066).
文摘Objective:To build a set of teaching staff construction and teaching quality monitoring system suitable for clinical practice teaching in affiliated hospitals of medical colleges,achieve continuous improvement of clinical education and teaching level,and ensure the quality of medical education talent cultivation.Methods:A modern clinical practice teaching quality monitoring system is constructed based on organizational structure construction,teaching staff system construction,quality control system construction,and information platform construction,combined with external audit and evaluation.Results:The hospital has established a Faculty Development and Teaching Evaluation Office specifically responsible for the cultivation of clinical teachers and the evaluation and supervision of teaching quality.A relatively complete teacher construction and teaching quality monitoring system has also been established for clinical practice teaching,thus achieving integration with the school’s quality control system in terms of management mechanism.At the same time,a set of teaching quality control mode based on the“Internet+”platform has been created by means of informatization.At present,this mode has won three national computer software copyrights and two second prizes for school-level teaching achievements.Conclusion:Through five years of practice,an“Internet+”teaching quality evaluation and monitoring system with the characteristics of teaching hospitals affiliated to local medical colleges has been established.In order to further standardize the training system of clinical teachers in affiliated hospitals,achieve self-monitoring and self-improvement in terms of teaching quality,and ensure the continuous improvement of clinical teaching quality,we will continue to promote the development of clinical teachers with quality and excellence,enrich the main team of quality monitoring,guide the transformation of the education mode from being“centered on teachers”to being“centered on students,”and realize the integration of internal and external quality monitoring systems.
文摘Roles of Marigold extracts (ME) on arsenic trioxide (ATO)-induced oxidative damage to pancreatic β-cells need to be further elucidated. In this study, NIT-1 cells were treated with different concentrations of and/or ATO, following by the cell viability was detected by CCK8 assay. Then, intracellular reactive oxygen species (ROS) levels, lipid peroxide (MDA) contents and superoxide dismutase (SOD) activity were measured with a fluorescence probe method and colorimetric assay, respectively. The apoptosis rate and morphology was detected and observed with hoechst 33,258 staining assay. The mRNA levels and protein expressions of nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were measured by real-time fluorescence quantitative polymerase chain reaction and protein immunoblotting assay, respectively. Our results indicated that Co-treatment with ME and ATO exacerbated the cell viability decreasing reduced by ATO, while the addition of ME after ATO treatment effectively promote the recovery of ATO reduced survival rates. The ATO group increased apoptosis (P P β-cells by modulating the activation of the Nrf2 signaling pathway.
基金2023 Shaanxi Teacher Development Research Program“Research on the Construction and Improvement Path of a Teaching Engagement Model for Double Qualified Teachers in Medical Colleges”(2023JSQ011)2022 Education and Teaching Reform Research Project of Xi’an Medical University“Construction and Practice of the Teaching Quality Assurance System in the Three-Level Teaching Base of General Practice Medicine under the Internet+Model”(2022JG-05)。
文摘Objective:This article aims to deeply analyze the feedback on teacher training in an affiliated hospital,so as to clarify the current needs and situation of teacher training and provide a scientific basis for further optimizing the teacher training system.Methods:The current situation and needs of teacher training in the affiliated hospital were collected by designing and distributing Tomato Form questionnaires on the DingTalk platform.The questionnaire adopted a percent-point system,all of which were indeterminate multiple-choice questions.Results:The average age of the clinical teachers participating in the survey was 40.44±7.85 years old,with an average teaching length of 4–10 years.The results showed that 60.20%of teachers think that the amount of teacher training in an affiliated hospital is sufficient;91.10%of teachers think that the factors affecting training conflict with working hours;97.96%of teachers believe that the training time has an impact on the training effect;81.63%of teachers prefer online training;51.53%of teachers tend to arrange training time on working days;33.16%of teachers tend to train once a month;17.78%of teachers prefer to receive training on clinical theoretical courses and practical teaching norms and skills content.Conclusion:Based on the above survey results,we propose to build a comprehensive management mechanism for teacher training,including improving the access,training,and assessment mechanism for clinical teachers,and adjusting and optimizing the training program according to actual needs.At the same time,an effective communication platform should be built to promote the deep integration of teaching and practice and enhance social recognition,so as to comprehensively improve the teaching quality and medical service of the hospital.
文摘With the continuous deepening of educational reform and the rapid development of higher education,as an important battlefield for knowledge dissemination,scientific research innovation,and social services,the financial management level of universities directly affects the efficiency of resource allocation,improvement of teaching quality,and sustainable development ability of the school.However,in the context of rapid expansion and diversified development,financial management in universities faces many challenges and problems.If not solved,it will inevitably negatively impact the management of universities and restrict their development.This article aims to deeply analyze the main problems in current financial management in universities and propose corresponding countermeasures and suggestions,to provide reference for improving the efficiency of financial management in universities.
基金Medical Research Project of Xi’an Science and Technology Bureau(Project No.22YXYJ0134)。
文摘Hepatocellular carcinoma is prone to invasion and metastasis.It often receives a low diagnosis rate in the early stage but has an extremely high mortality rate.Epithelial-mesenchymal transformation(EMT)is a key factor in promoting tumor cell invasion and metastasis.Circular RNA(circRNA)is involved in regulating EMT in hepatocarcinoma cells through multiple pathways,thereby affecting the occurrence and progression of hepatocellular carcinoma.This article mainly reviews the research progress of circRNA related to EMT core transcription factors,circRNA that promotes EMT in liver cancer,and circRNA that inhibits EMT in liver cancer.
基金2023 Shaanxi Teacher Development Research Program“Research on the Construction and Improvement Path of a Teaching Engagement Model for Double-Qualified Teachers in Medical Colleges”(Project number:2023JSQ011)。
文摘Taking role conflict as the starting point,this article examines and reflects on the development of clinical teachers.In the process of the occurrence,development,and resolution of role conflicts among clinical teachers,there are many hidden issues related to the development of clinical teachers.The development of clinical teacher teaching and role conflict management contain similar educational philosophies and practical issues.This study draws on classic theories and research achievements in the development of university teachers and conducts theoretical analysis and practical reflection on the development of clinical teachers in medical colleges from the perspective of role conflict in social psychology.Policy recommendations are proposed,including strengthening the construction of teaching systems at the hospital organizational environment level,enhancing the role identity and teacher beliefs of clinical teachers,promoting their teaching development and academic learning,and ensuring their normal teaching investment;promoting leadership support at the level of interpersonal interaction and leveraging the role of colleague support in alleviating role conflicts;enhancing individual teacher beliefs,teacher role learning,and role skills.
基金Sponsored by the Natural Science Fund Project of Jiangsu Provincial Science and Technology Department(No.BK20131418)the Jiangsu Provincial Social Science Fund Project(No.13LSB007)the Jiangsu Colleges and Universities Superior Subject(Traditional Chinese Medicine)Fund(No.PAPD)
文摘OBJECTIVE: To analyze treatment effectiveness in terms of the medication injection site. METHODS: The medical records of 423 patients with cerebral palsy who were admitted to Maternal and Child Health Hospital between January 2009 and December 2016 were collected. All cases were divided into T1, T2, T3, and T4 groups based on the use of conventional medication sites and acupoints for administering injectable medicines. RESULTS: In the T1 group, patients received injections at conventional medication sites between 2009 and 2010. In the T2 group, patients received injections at conventional medication sites combined with acupoint injection therapy I from 2011 to 2012. In the T3 group, injection at conventional medication sites plus acupoint injection II was applied between 2013 and 2014. Acupoint injection only was used in the T4 group from 2015 to 2016. Therapeutic effects were statistically compared among the different injection procedures. The overall Gross Motor Function Measure (GMFM) and Fine Motor Function Measure (FMFM) scores were significantly improved after hospital discharge. The GMFM score was considerably higher in the T4 group than in the other groups (all P = 0.001 < 0.05). The GMFM scores were significantly higher in the T2 groups than in the T1 group (P = 0.001< 0.05), but no significant difference was observed between the other paired comparions (P > 0.05). Meanwhile, the FMFM scores were significantly higher in the T2 and T4 groups than in the T1 and T3 groups (all P = 0.001 < 0.05). Site injection therapy can significantly improve gross and fine motor function in children with cerebral palsy. CONCLUSION: It is feasible to administer injectable medicines at acupoints instead of convention sites to enhance the therapeutic effect of treatment in patients with cerebral palsy.
文摘COVID-19 has changed the way of learning and life of college students.The purpose is to explore the relationship between perceived stress and anxiety,and the mediating effect of resilience and regulatory emotional self-efficacy in college students during COVID-19.309 students from three colleges were selected as research participants(average age 19.79±1.11 years).SPSS was used to measure the correlation between variables.Amos was used to test the path coefficient and mediating effect of the hypothetical model.The results show that:Firstly,perceived stress has a significantly and positively predictive effect on anxiety.Secondly,psychological resilience and regu-latory emotional self-efficacy independently played a significant and partially mediating effect between perceived stress and anxiety.Among them,perceived stress had a negative predictive effect on psychological resilience and regulatory emotional self-efficacy.Psychological resilience and regulatory emotional self-efficacy had a negative predictive effect on anxiety.Thirdly,psychological resilience and regulatory emotional self-efficacy play a chain mediation role between psychological stress and anxiety.Regulatory emotional self-efficacy cannot only directly predict the level of anxiety,but also indirectly predict the level of anxiety by regulating psychological resilience.This study reveals the relationship between college students’perceived stress and anxiety,and the mediating effect of psychological resilience and regulatory emotional self-efficacy in the new time of COVID-19.The chain mediation role of psychological resilience and regulatory emotional self-efficacy reminds college mental health educators that improving students’regulatory emotional self-efficacy is an important way to promote students’mental health.
基金Effect of general education in colleges and universities practice researchEducation in Jiangsu province“Twelfth Five-year Plan”scientific research project.No.:C-b/2011/01/28
文摘General education has become more and more attention.The culture has a more long-term and lasting contribution,so more and more colleges and universities have adopted a series of reform measures.Effect of the practice of general education,however,still cannot satisfactory.In this paper,main factors affecting was analyzed on the basis of extensive research and questionnaire data analysis and targeted put forward the optimization effect of general education.It is important to make every effort to make the general education in China to achieve"Phoenix Nirvana".
基金Supported by the Ministry of Science and Technology,Taiwan,No.MOST 104-2314-B-016-010-MY2 and No.MOST 106-2320-B-016-018the Ministry of National Defense,Taiwan,No.MAB-107-075,No.MAB-108-057and No.MAB-109-061
文摘BACKGROUND It is evident that current clinical criteria are suboptimal to accurately estimate patient prognosis.Studies have identified epigenetic aberrant changes as novel prognostic factors for colorectal cancer(CRC).AIM To estimate whether a methylation gene panel in different clinical stages can reflect a different prognosis.METHODS We enrolled 120 CRC patients from Tri-Service General Hospital in Taiwan and used the candidate gene approach to select six genes involved in carcinogenesis pathways.Patients were divided into two groups based on the methylation status of the six evaluated genes,namely,the<3 aberrancy group and≥3 aberrancy group.Various tumor stages were divided into two subgroups(local and advanced stages)on the basis of the pathological type of the following tissues:Tumor and adjacent normal tissues(matched normal).We assessed DNA methylation in tumors and adjacent normal tissues from CRC patients and analyzed the association between DNA methylation with different cancer stages and the prognostic outcome including time to progression(TTP)and overall survival.RESULTS We observed a significantly increasing trend of hazard ratio as the number of hypermethylated genes increased both in normal tissue and tumor tissue.The 5-year TTP survival curves showed a significant difference between the≥3 aberrancy group and the<3 aberrancy group.Compared with the<3 aberrancy group,a significantly shorter TTP was observed in the≥3 aberrancy group.We further analyzed the interaction between CRC prognosis and different cancer stages(local and advanced)according to the methylation status of the selected genes in both types of tissues.There was a significantly shorter 5-year TTP for tumors at advanced stages with the promoter methylation status of selected genes than for those with local stages.We found an interaction between cancer stages and the promoter methylation status of selected genes in both types of tissues.CONCLUSION Our data provide a significant association between the methylation markers in normal tissues with advanced stage and prognosis of CRC.We recommend using these novel markers to assist in clinical decision-making.
基金funded by the National Natural Science Foundation of China (31470496)the Fundamental Research Funds for the Central Universities, China (lzujbky-2021-sp42)the ‘111’ Programme 2.0, China (BP0719040)。
文摘Plastic film mulch in agricultural production becomes essential to maintaining crop yields in arid and semiarid areas.However,the presence of residual film in farmland soil has also drawn much attention.In this study,three experiments were conducted.The first two experimental designs included 0,450,1350,and 2700 kg ha^(-1) of residual film pieces of approximately 5 cm side length added to field soil(0-20 cm soil depth)for seven years and added to pots for four years.In the third experiment,1350 kg ha^(-1)of the residual film with different side lengths(2-5,5-10,10-15,and 15-20 cm)was added to field soil for six years to explore the effect of residual film fragment size on soil nutrients,soil microorganisms,crop growth and yields.The residual film had little effect on the soil moisture at a field depth of 0-2(or 0-1.8)m.There were no significant effects on organic carbon,total nitrogen,inorganic nitrogen,total phosphorus or available phosphorus in the 0-20 cm soil layer.The presence of residual film decreased the richness and diversity of the bacterial community of the surface soil of the residual film,but it had no significant effect on the microbial community of the non-surface soil.The emergence rates of wheat and lentils occasionally decreased significantly with different amounts of residue fragments added to the field.At 450-2700 kg ha^(-1),the residual film reduced the plant height and stem diameter of maize and significantly reduced the shoot biomass of harvested maize by 11-19%.The average yields of maize and potato over the seven years decreased,but there were almost no significant statistical differences among the treatments.These results provide important data for a comprehensive scientific understanding of the effects of residual film on soil and crops in dryland farming systems.
文摘To achieve the production information management of the coning,drawing and twisting's workshop,and promote a good and fast development of the textile enterprise,firstly,we analyze the information technology development status of the textile enterprise at home and abroad,study the weaknesses of the existing computer monitoring system,introduce the system design project,and propose a system network model based on client/server(C/S)mode.Secondly,a multi-agent production monitoring and control system is developed,and the communication of the single-port-multi-protocol and a multi-thread data collection technology are studied via the multi-thread and standard template library(STL)technologies.Thirdly,the system management functions,the structure design of the database,and the technical difficulties in the process of software design are also introduced.As proved in practice,the system satisfies the production management requirements of the workshop,and implements the network management of the production information.
基金International Cooperative Research Project of China(No.2006DFA73180)
文摘New open manufacturing environments have been proposed aiming at realizing more flexible distributed manufacturing paradigms,which can deal with not only dynamic changes in volume and variety of products,but also changes of machining equipments,dispersals of processing locations,and also with unscheduled disruptions.This research is to develop an integrated process planning and scheduling system,which is suited to this open,dynamic,distributed manufacturing environment.Multi-agent system(MAS)approaches are used for integration of manufacturing processing planning and scheduling in an open distributed manufacturing environment,in which process planning can be adjusted dynamically and manufacturing resources can increase/decrease according to the requirements.One kind of multi-level dynamic negotiated approaches to process planning and scheduling is presented for the integration of manufacturing process planning and scheduling.
文摘Cat on a Hot Tin Roof,written by Tennessee Williams in 1955,is a brilliant play about a dysfunctional family.In this play,Williams uses his craft to entertain,enlighten and bare men's soul in morden society.By analyzing its major characters,themes and symbols,this paper tries to show this play's contemporary significance.
基金Supported by the National High Technology Research and Development Program of China under Grant No 2007AA03Z116, the Natural Science Foundation of Hebei Province （E2008000194）, and the Science Foundation of Hebei Education Department （2009133）.
文摘Considering different contact situations of grains, we effective anisotropies of magnetically soft α-Fe grains, investigate the effects of exchange-coupling interaction on hard Nd2Fe14B grains and NdaFe14B/α-Fe nanocomposite. An expression of effective anisotropy suitable for different degrees of exchange-coupling between grains is presented. The calculation results show that the exchange-coupling interaction increases the average anisotropy of soft grains and decreases that of hard grains. The effective anisotropy of Nd2Fe14B/α-Fe nanocomposite decreases smoothly with decreasing grain size when the grain size is larger than 20 nm while it decreases dramaticaily with further decrease of the grain size. In order to maintain high coercivity in Nd2Fe14B/α-Fe nanoeomposite, the grain size should not be less than 20nm.
