Objective To improve the accuracy and professionalism of question-answering(QA)model in traditional Chinese medicine(TCM)lung cancer by integrating large language models with structured knowledge graphs using the know...Objective To improve the accuracy and professionalism of question-answering(QA)model in traditional Chinese medicine(TCM)lung cancer by integrating large language models with structured knowledge graphs using the knowledge graph(KG)to text-enhanced retrievalaugmented generation(KG2TRAG)method.Methods The TCM lung cancer model(TCMLCM)was constructed by fine-tuning Chat-GLM2-6B on the specialized datasets Tianchi TCM,HuangDi,and ShenNong-TCM-Dataset,as well as a TCM lung cancer KG.The KG2TRAG method was applied to enhance the knowledge retrieval,which can convert KG triples into natural language text via ChatGPT-aided linearization,leveraging large language models(LLMs)for context-aware reasoning.For a comprehensive comparison,MedicalGPT,HuatuoGPT,and BenTsao were selected as the baseline models.Performance was evaluated using bilingual evaluation understudy(BLEU),recall-oriented understudy for gisting evaluation(ROUGE),accuracy,and the domain-specific TCM-LCEval metrics,with validation from TCM oncology experts assessing answer accuracy,professionalism,and usability.Results The TCMLCM model achieved the optimal performance across all metrics,including a BLEU score of 32.15%,ROUGE-L of 59.08%,and an accuracy rate of 79.68%.Notably,in the TCM-LCEval assessment specific to the field of TCM,its performance was 3%−12%higher than that of the baseline model.Expert evaluations highlighted superior performance in accuracy and professionalism.Conclusion TCMLCM can provide an innovative solution for TCM lung cancer QA,demonstrating the feasibility of integrating structured KGs with LLMs.This work advances intelligent TCM healthcare tools and lays a foundation for future AI-driven applications in traditional medicine.展开更多
Allergic diseases,encompassing a wide array of conditions such as allergic rhinitis(AR),allergic asthma(AAS),atopic dermatitis(AD),and food allergy(FA),among others,represent a significant menace to global public heal...Allergic diseases,encompassing a wide array of conditions such as allergic rhinitis(AR),allergic asthma(AAS),atopic dermatitis(AD),and food allergy(FA),among others,represent a significant menace to global public health.The heterogeneity of these diseases,along with their intricate pathogenesis and propensity for recur-rence,has spurred an escalating demand for efficacious therapeutic strategies.Notwithstanding the advance-ments in western medicine(WM),treatment modalities like antihistamines,sulfonamides,and glucocorticoids exhibit side effects,especially for the neurotoxicity and the adverse reactions of the digestive system.Addi-tionally,physical therapies utilized in allergy management frequently perturb skin metabolism,potentially resulting in stratum corneum impairment,atrophy,pigmentation,and relapse,thereby mandating further investigation and optimization.The management of allergic disorders is often typified by recurrence and diffi-culties in attaining a definitive cure,instigating the pursuit of alternative or adjunctive therapeutic regimens.In this regard,Traditional Chinese Medicine(TCM),which adopts a comprehensive and holistic view of health and disease,confers remarkable advantages in the treatment of allergic conditions.TCM accentuates the significance of personalized treatment,custom-tailored to each patient’s idiosyncratic constitution and disease manifestations,a principle that is especially germane in allergic conditions where standardized treatments frequently fall short.Moreover,TCM interventions,including herbal remedies,acupuncture,and other modalities,are generally associated with a lower incidence of adverse effects compared to conventional therapies,rendering them appealing options for long-term management.The holistic paradigm of TCM permits the concurrent modulation of multiple physiological systems,not only alleviating the symptoms but also rectifying the underlying imbalances that underpin the development and perpetuation of allergic diseases.This approach,in conjunction with the capacity to individualize treatments,implies that TCM harbors sub-stantial potential in conferring more comprehensive and sustainable relief from allergic symptoms.This article delves into the TCM perspective on allergic diseases and the contemporary value of TCM in their treatment.It further explores the developmental pathway of TCM in addressing allergic diseases,dissects the intersection points between traditional theories and modern science,summarizes the key findings and conclusions,and emphasizes the potential and prospects of TCM in this domain.展开更多
The quality of traditional Chinese medicine(TCM)prescriptions(TCMPs)is critical to clinical efficacy;however,evaluating their consistency and identifying sources of variability remain challenging.This study proposes a...The quality of traditional Chinese medicine(TCM)prescriptions(TCMPs)is critical to clinical efficacy;however,evaluating their consistency and identifying sources of variability remain challenging.This study proposes an integrated strategy to assess the quality of 100 widely sold TCMPs.A"one-for-all"chromatographic method was employed to analyze 645 sample batches.This large-scale data collection enabled statistical evaluations,such as hierarchical cluster analysis(HCA)and similarity heatmap,to identify quality inconsistencies.The introduction of a TCM-specific mass spectrometry(MS)database allowed for rapid,automated annotation of chemicals across 100 prescriptions and facilitated the tracing of raw material sources.Results indicate that 19%of prescriptions exhibited chemical inconsistencies,which are associated with high market value,low pricing,and substantial price disparities.The MS database allowed rapid annotation of 761 and 673 compounds in positive and negative modes,respec-tively,in 100 TCMPs,with 73 prescriptions reported for the first time.The tracing efforts succeeded in identifying>40%of the raw material sources for 51 prescriptions.P93(Yinianjin(YNJ))is a case in which the chromatographic profiles from three manufacturers displayed inconsistencies.Analysis using the database traced divergent peaks to Rhei Radix et Rhizoma(RRER).Verification with self-prepared samples confirmed that manufacturers utilized three distinct botanical sources.This integrated strategy provides a scalable framework for quality control in TCMPs.展开更多
The significance of apoptosis in gastric cancer is now widely recognized, and the induction of apoptosis as a new approach to treat gastric cancer has aroused great interest. In recent years, studies on certain TCM dr...The significance of apoptosis in gastric cancer is now widely recognized, and the induction of apoptosis as a new approach to treat gastric cancer has aroused great interest. In recent years, studies on certain TCM drugs for treating gastric cancer and for inducing apoptosis have brought about great attention both at home and abroad. The following is a summary made in this aspect.展开更多
Objective: To evaluate the clinical effect and quality of life (QOL) in coronary artery bypass grafting (CABG) patients treated according to syndrome differentiation of TCM. Methods: Eighty-two CABG patients were allo...Objective: To evaluate the clinical effect and quality of life (QOL) in coronary artery bypass grafting (CABG) patients treated according to syndrome differentiation of TCM. Methods: Eighty-two CABG patients were allocated in the control group (n = 39) treated with conventional method of western medicine, and the TCM-treated group (n展开更多
The ideal hypotensive agent should possess three essentials, i.e. to depress the blood pressure surely and steadily, and to block the renin-angio-tensin system (RAS)(1). Currently, Western medical treatment could depr...The ideal hypotensive agent should possess three essentials, i.e. to depress the blood pressure surely and steadily, and to block the renin-angio-tensin system (RAS)(1). Currently, Western medical treatment could depress the blood pressure rapidly and surely through reducing blood volume and dilating blood vessels, while traditional Chinese medicine (TCM) shows its superiorities in al-展开更多
Acupuncture at the Taichong (LR 3), Sanyinjiao (SP 6) and Ciliao (BL 32) points combined with TCM drugs for soothing the liver, replenishing the kidney, freeing the seminal passage, and eliminating the stasis showed e...Acupuncture at the Taichong (LR 3), Sanyinjiao (SP 6) and Ciliao (BL 32) points combined with TCM drugs for soothing the liver, replenishing the kidney, freeing the seminal passage, and eliminating the stasis showed effective for functional retrograde ejaculation in 25 cases. The total effective rate of 68.0% was significantly better than imipramine used in the control group (P<0.05).展开更多
A Spanish businessman becomes a dedicated advocate of traditional Chinese medicine after witnessing its effects in treating his terminally ill young son.MY relationship with traditional Chinese medicine(TCM)-and with ...A Spanish businessman becomes a dedicated advocate of traditional Chinese medicine after witnessing its effects in treating his terminally ill young son.MY relationship with traditional Chinese medicine(TCM)-and with China-began in 1988,when I traveled to Beijing with my two-year-old son Joan.He was suffering from an extremely rare disease called leukoencephalopathy,in which the brain is affected,and we wanted to explore treatment possibilities.展开更多
Parkinson's disease (PD) is a chronic degenerative disease of the nervous system marked by tremor,muscle rigidity, hypokinesis, abnormal posture, and pathologically, selective loss of dopaminergic neurons in the s...Parkinson's disease (PD) is a chronic degenerative disease of the nervous system marked by tremor,muscle rigidity, hypokinesis, abnormal posture, and pathologically, selective loss of dopaminergic neurons in the substantia nigra of the midbrain and obvious decrease of dopamine content in the striatum.It is encountered mostly in the middle-aged and old persons and is one of main causes inducing their deformity. The morbidity of this disease tends to increase with gradual aging of the population. In recent years, TCM treatment of this disease has obtained gratifying achievements. A review follows.展开更多
Objective:To explore whether the traditional Chinese medicine(TCM)Bu Jing Yi Shi Tablets alters the expression of scleral TGF-b1 and Smad3 in guinea pigs with formdeprivation myopia(FDM).Methods:Sixty-five guinea pigs...Objective:To explore whether the traditional Chinese medicine(TCM)Bu Jing Yi Shi Tablets alters the expression of scleral TGF-b1 and Smad3 in guinea pigs with formdeprivation myopia(FDM).Methods:Sixty-five guinea pigs were randomly divided into control,model,low-,medium-,and high-dose treatment groups.Except for the control group,FDM was induced by covering the right eye of each animal with opaque latex.The treatment groups were gavaged with different suspension concentrations of Bu Jing Yi Shi Tablets.Refraction and axial length were performed before and after myopia induction.At the end of the experiment,all right eyes were extracted,and scleral sections were prepared for staining and TGF-b1 and Smad3 immunohistochemistry.Scleral thickness and area,the scleral fibroblast quantity,and scleral TGFb1 and Smad3 expressions were measured.Results:The 5 FDM groups had the same initial axial length and diopter,the final diopter and axial length of the model group were significantly increased compared with the control group and treatment groups(P<.01).The axial length of each treatment group decreased as the dose decreased compared with the model group(P<.01);the total scleral area(P<.05 e.01)and the number of scleral fibroblasts(P<.01)in the model group were significantly lower than the treatment groups.Both the TGF-b1 and Smad3 integral optical densities in the model group were significantly lower than the control and medium-and high-dose treatment groups(P<.01).TGF-b1 and Smad3 mRNAs in the model group were decreased compared with the control group,but increased in expression after treatment.展开更多
TCM formulae are the important guidances for clinical application of traditional Chinese medicines,which follow the principles of diagnosis and treatment in TCM.Elucidating the bio-active components of TCM formulae is...TCM formulae are the important guidances for clinical application of traditional Chinese medicines,which follow the principles of diagnosis and treatment in TCM.Elucidating the bio-active components of TCM formulae is the key to the modernization and internationalization of traditional Chinese medicines.With the rapid development of modern instruments and technology,many new theories,methods and strategies are emerging,which upgrade the research of TCM formulae into a higher level.Only when the medicinal efficacy,bio-active components,function mechanism of TCM formulae are understood,we can guarantee TCM safety and quality control.In this paper,we summarized the latest modern research thoughts and methods on bio-active components of TCM formulae including formula decomposition study,serum pharmacology and serum pharmacochemistry,association analysis,biochro-matography,network pharmacology,metabolomics and proteomics,so as to provide reference for the research and development of TCM in the future.展开更多
Microcirculatory changes and therapeutic effects in 39 non-insulin dependent diabetes mellitus (NIDDM) cases were evaluated. Under the same basic treatment in both groups, the treatment group (21 cases) was treated wi...Microcirculatory changes and therapeutic effects in 39 non-insulin dependent diabetes mellitus (NIDDM) cases were evaluated. Under the same basic treatment in both groups, the treatment group (21 cases) was treated with TCM drugs according to its stages and compared with the control group (18 cases, treated with 654-2). The results showed that the microcirculatory cumulative scores were significantly decreased in both groups (P<0.05), but the decrease in the treatment group was more marked (P<0.05). In the treatment group, 15 cases were cured, 3 markedly effective, 2 effective and 1 ineffective; while in the control group, 13 cases were cured, 1 markedly effective and 4 ineffective. Statistically, there is no significant difference between the 2 groups (P>0.05) in therapeutic effects.展开更多
Objective: To simplify the TCM pattern of the zang-fu organs. Methods: A database of zang-fu syndromes was established. The relationship between the zang-fu syndromes was analyzed by means of frequency analysis, assoc...Objective: To simplify the TCM pattern of the zang-fu organs. Methods: A database of zang-fu syndromes was established. The relationship between the zang-fu syndromes was analyzed by means of frequency analysis, association rule, and ф-coefficient correlation. Results: The six zang-fu organs of the heart, liver, spleen, lung, kidney, and stomach prove to be the main components of the zang-fu pattern. The large intestine, small intestine, gallbladder, bladder, triple energizer, and pericardium have strong association and positive correlation with the above-mentioned six zang-fu organs, and their clinical symptoms can all be included into the symptoms of these six zang-fu organs. Conclusion: The traditional TCM pattern of six-zang and six-fu can be simplified into five-zang and one-fu.展开更多
Objective: To study the distribution and development rules of the TCM syndromes in psoriasis vulgaris. Methods: Based on the clinical epidemiologic mass survey, the study was carried out by means of a status survey, m...Objective: To study the distribution and development rules of the TCM syndromes in psoriasis vulgaris. Methods: Based on the clinical epidemiologic mass survey, the study was carried out by means of a status survey, multi-center and large-sample research. The data base was set up by EPIINFO6.0. The SPSS was used to do the statistical analyses in 2651 cases of psoriasis vulgaris to study the correlations among the distribution and development of the TCM syndromes, the stages of the disease, nationality, psoriasis history, family history, smoking history, alcohol drinking history, and severity of the disease. Results: The TCM syndromes in psoriasis vulgaris mainly include the blood-heat syndrome (53.8%), blood-dryness syndrome (27.4%), and blood-stasis syndrome (18.1%). Other syndromes were rarely seen, covering 0.6%. The concurrent syndromes mainly involve dampness, heat, blood stasis and toxin. The distribution differences of the main syndromes at different stages of the disease had statistical significance (P<0.01). The syndrome distribution is not related with nationality and family history (P>0.05), but it was closely related with the psoriasis history, smoking history, alcohol drinking history, and severity of the disease (P<0.01). Conclusion: At the initial stage, psoriasis vulgaris usually manifests itself as the blood-heat syndrome, and later it may be improved or turn into the blood-dryness or blood-stasis syndrome. Smoking, alcohol consumption, and severity of the disease may play a role in the syndrome's transformation.展开更多
Objective: To discuss the relationship between the postoperative breast cancer with distant metastasis and the TCM syndromes classification. Methods: 160 postoperative 5-year breast cancer patients from 1995 to 2000 w...Objective: To discuss the relationship between the postoperative breast cancer with distant metastasis and the TCM syndromes classification. Methods: 160 postoperative 5-year breast cancer patients from 1995 to 2000 were tracked, summed up and analysized TCM syndromes as stagnation of hepatic qi, deficiency of spleen and pathogenic phlegm reten- tion, blood stasis and toxin stagnation, deficiencies of both blood and qi. Results: (1) For blood stasis and toxin stagnation TCM syndrome, the metastatic rate raised to 45% during 5 years. However, the metastatic rates of other three TCM syn- dromes are 15%, 17.5% and 22.5% respectively. The general distant metastasis rate was 27.5% (P<0.01). (2) Lymph node metastasis, tumor size, Her-2 and its receptor have no obvious relation with TCM syndromes classification (P>0.05). Conclu- sion: (1) TCM syndrome classification has close relation with breast cancer distant metastasis. Distant metastasis have close relationship with blood stasis and toxin stagnation syndrome. (2) Lymph node metastasis, tumor size, Her-2 and its receptor have no obvious relation with TCM syndromes classification, which suggested that metastatic ability has been programmed in the early stage of carcinoma initiation. (3) Significantly enlightening for predict the prognosis under the guide of TCM syn- drome classification and take right therapeutic strategy: attack pathogen and activate blood circulation against cancer.展开更多
[Objectives]To analyze the characteristics and rules of traditional Chinese medicine(TCM)in the treatment of decreased ovarian reserve(DOR)in Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine.[M...[Objectives]To analyze the characteristics and rules of traditional Chinese medicine(TCM)in the treatment of decreased ovarian reserve(DOR)in Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine.[Methods]A total of 107 patients with DOR in Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine were selected for sorting,and the usage,classification,nature,taste and meridian homing of the used drugs were statistically analyzed.[Results]A total of 107 patients were included in this stud and a total of 189 flavors of TCM are used.The total frequency of drugs was 4345 times,and a total of 535 prescriptions were issued.The top five frequency of drug use were 2261 times(50.04%)of Paeoniae Radix Alba(Cynanchum otophyllum Schneid.),2037 times(46.88%)of Corni Fructus(Cornus officinalis Sieb.et Zucc.),1818 times(41.84%)of Rehmanniae Radix Praeparata[Rehmannia glutinosa(Gaertn.)Libosch EX Fisch.et Mey.],1610 times(37.05%)of Guiban[Chinemys reevesii(Gray)],and 1303 times(29.99%)of Uncariae Ramulus Cum Uncis(Uncariar hynchophylla Miq.ex Havil.).Kidney deficiency syndrome accounted for the largest proportion at 51.40%,and the use frequency of tonic drugs accounted for the highest at 50.64%;heat-clearing drugs and qi and blood-boosting drugs separately accounted for 19.24%and 17.39%;the top 3 medicinal tastes are sweet(52.02%),pungent(20.71%)and bitter(20.32%);medicinal properties are ranked as warm(60.54%),cold(24.16%),hot(8.72%)and cool(6.49%);the main meridians are spleen,lung,liver,stomach and kidney.[Conclusions]The basic pathogenesis of DOR is deficiency of qi and blood,mainly due to dysfunction of the spleen,lung,liver,liver,stomach and other organs,and kidney deficiency and spleen deficiency are more common.展开更多
Objective: To evaluate the short-term therapeutic effects of TCM for IgA nephropathy in children. Methods: Sixty-two children with primary IgA nephropathy diagnosed for the first time by renal biopsy in the authors’ ...Objective: To evaluate the short-term therapeutic effects of TCM for IgA nephropathy in children. Methods: Sixty-two children with primary IgA nephropathy diagnosed for the first time by renal biopsy in the authors’ hospital were randomly divided into a group of 34 cases treated with both TCM and Western medicine and a group of 28 cases treated with Western medicine for six months. The improvements in urinary protein and red blood cell (RBC) were observed and the scores for TCM symptoms and signs were evaluated after 3 months and 6months of treatment. Results: There was no significant difference in the total effective rate between the two groups (χ2=4.743, P>0.05 after treatment for 3 months; and χ2=1.953, P>0.05 after treatment for 6 months). However, the cure plus marked effect rate in the group treated with both TCM and Western medicine was higher than that in the group treated with Western medicine (71.9% vs 45.5%, P<0.05 after treatment for 3 months). At the end of treatment, significant difference were found in the effective rate (9.3% vs 10.5%, χ2=9.653, P<0.01) and in the total score (0.81+1.18 vs 3.42+2.52,t=4.19, P<0.001) between the two groups. Conclusion: Treatment with both TCM and Western medicine can effectively improve the TCM symptoms and signs in child patients with IgA nephropathy, and alleviate hematuria and albuminuria.展开更多
The therapeutic effects in treating the intermediate and late rheumatoid arthritis by supplementing the kidney and invigorating blood circulation were observed. In the 43 cases of the treatment group, No. 2 Qu Feng Sh...The therapeutic effects in treating the intermediate and late rheumatoid arthritis by supplementing the kidney and invigorating blood circulation were observed. In the 43 cases of the treatment group, No. 2 Qu Feng Shi Ling capsules (祛风湿灵胶囊2号) and Fenbid (芬必得) were prescribed, while in the 39 cases of the control group Lei Gong Teng Tablets (雷公藤总甙片) and Fenbid were given. The results showed that the total effective rate in the treatment group was more satisfactory than that in the control (P<0.05 or P<0.01). With less toxic effects, the former could better improve the local swelling and lower the blood viscosity.展开更多
Objective:To explore the effective prevention and treatment of portal hypertension(PH).Methods:A total of 220 patients who came to our hospital from March 2015 to October 2018 were treated.They were randomly divided i...Objective:To explore the effective prevention and treatment of portal hypertension(PH).Methods:A total of 220 patients who came to our hospital from March 2015 to October 2018 were treated.They were randomly divided into the treatment group and the control group,each with 110 cases.Before treatment,there was no significant differences in age,sex,clinical symptoms,signs,laboratory tests and color Doppler ultrasound related examinations between the 2 groups(P>0.05).Among them,the treatment group on the basis of traditional Chinese and Western medicine treatment in our hospital,the Qi-acupuncture therapy of TCM was added.The extra meridian acupoints along with acupoints were selected.The control group received conventional treatment with traditional Chinese and Western medicine in our hospital.Results:There were significant differences in clinical symptoms,signs and chemistry between groups after treatment(P<0.01).There were significant differences in test,color ultrasound related examination and so on(P<0.01).Those in the treatment group was significantly better than the control group(P<0.01).Conclusion:On the basis of the Qi-acupuncture therapy of TCM,selecting extra meridian acupoint and acupoints can effectively treat PH.展开更多
Objective:Inquiry occupies an important position in the Traditional Chinese Medicine(TCM)diagnostic methods.Observing the characteristics of inquiry symptoms and the correlation with TCM syndromes can determine the im...Objective:Inquiry occupies an important position in the Traditional Chinese Medicine(TCM)diagnostic methods.Observing the characteristics of inquiry symptoms and the correlation with TCM syndromes can determine the important guiding significance to build recognition model and diagnostic criteria of syndrome.Methods:In this study,we collected 3707 valid cases,analyzed the inquiry symptoms of patients with cardiovascular disease,then to explore the distribution of inquiry information and the correlation with TCM syndromes based on the methods,such as frequency analysis,expert score,and correlation analysis.Results:We found the symptoms of frequency analysis and expert symptom score all in the top 50,add up to 41.According to the results by correlation analysis,the correlation coefficient between each symptom and each syndrome are sorted from high to low,the same with the experts score to each inquiry symptom basing on its importance of in diagnosing each syndrome.Conclusion:Inquiry occupies an important effect in differentiation syndrome.This research could provide certain objective basis for establishment of TCM syndromes diagnostic criteria of cardiovascular disease,thus provide some ideas and methods for the research of establishing TCM syndrome identification model,then to provide a reference for the syndrome standardization and objectification.展开更多
基金Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX24_2145).
文摘Objective To improve the accuracy and professionalism of question-answering(QA)model in traditional Chinese medicine(TCM)lung cancer by integrating large language models with structured knowledge graphs using the knowledge graph(KG)to text-enhanced retrievalaugmented generation(KG2TRAG)method.Methods The TCM lung cancer model(TCMLCM)was constructed by fine-tuning Chat-GLM2-6B on the specialized datasets Tianchi TCM,HuangDi,and ShenNong-TCM-Dataset,as well as a TCM lung cancer KG.The KG2TRAG method was applied to enhance the knowledge retrieval,which can convert KG triples into natural language text via ChatGPT-aided linearization,leveraging large language models(LLMs)for context-aware reasoning.For a comprehensive comparison,MedicalGPT,HuatuoGPT,and BenTsao were selected as the baseline models.Performance was evaluated using bilingual evaluation understudy(BLEU),recall-oriented understudy for gisting evaluation(ROUGE),accuracy,and the domain-specific TCM-LCEval metrics,with validation from TCM oncology experts assessing answer accuracy,professionalism,and usability.Results The TCMLCM model achieved the optimal performance across all metrics,including a BLEU score of 32.15%,ROUGE-L of 59.08%,and an accuracy rate of 79.68%.Notably,in the TCM-LCEval assessment specific to the field of TCM,its performance was 3%−12%higher than that of the baseline model.Expert evaluations highlighted superior performance in accuracy and professionalism.Conclusion TCMLCM can provide an innovative solution for TCM lung cancer QA,demonstrating the feasibility of integrating structured KGs with LLMs.This work advances intelligent TCM healthcare tools and lays a foundation for future AI-driven applications in traditional medicine.
基金supported by the General program of National Natural Science Foundation of China(No.82174243,82204948)the General project of Beijing Natural Science Foundation(No.7242227).
文摘Allergic diseases,encompassing a wide array of conditions such as allergic rhinitis(AR),allergic asthma(AAS),atopic dermatitis(AD),and food allergy(FA),among others,represent a significant menace to global public health.The heterogeneity of these diseases,along with their intricate pathogenesis and propensity for recur-rence,has spurred an escalating demand for efficacious therapeutic strategies.Notwithstanding the advance-ments in western medicine(WM),treatment modalities like antihistamines,sulfonamides,and glucocorticoids exhibit side effects,especially for the neurotoxicity and the adverse reactions of the digestive system.Addi-tionally,physical therapies utilized in allergy management frequently perturb skin metabolism,potentially resulting in stratum corneum impairment,atrophy,pigmentation,and relapse,thereby mandating further investigation and optimization.The management of allergic disorders is often typified by recurrence and diffi-culties in attaining a definitive cure,instigating the pursuit of alternative or adjunctive therapeutic regimens.In this regard,Traditional Chinese Medicine(TCM),which adopts a comprehensive and holistic view of health and disease,confers remarkable advantages in the treatment of allergic conditions.TCM accentuates the significance of personalized treatment,custom-tailored to each patient’s idiosyncratic constitution and disease manifestations,a principle that is especially germane in allergic conditions where standardized treatments frequently fall short.Moreover,TCM interventions,including herbal remedies,acupuncture,and other modalities,are generally associated with a lower incidence of adverse effects compared to conventional therapies,rendering them appealing options for long-term management.The holistic paradigm of TCM permits the concurrent modulation of multiple physiological systems,not only alleviating the symptoms but also rectifying the underlying imbalances that underpin the development and perpetuation of allergic diseases.This approach,in conjunction with the capacity to individualize treatments,implies that TCM harbors sub-stantial potential in conferring more comprehensive and sustainable relief from allergic symptoms.This article delves into the TCM perspective on allergic diseases and the contemporary value of TCM in their treatment.It further explores the developmental pathway of TCM in addressing allergic diseases,dissects the intersection points between traditional theories and modern science,summarizes the key findings and conclusions,and emphasizes the potential and prospects of TCM in this domain.
基金the Guangxi Science and Technology Major Project/Program,China(Grant Nos.:GUIKEAA22096029,GUIKEAA23023035)State Key Laboratory of Drug Regulatory Science Project,National Institutes for Food and Drug Control(NIFDC),China(Grant No.:2024SKLDRS0101)+1 种基金Shanghai Institute of Material Medical(SIMM)-National EngineeringResearch Center of TCM Standardization Technology Independent Research Program,Chinathe staff members of the Large-scale MS System at the National Facility for Protein Science in Shanghai(NFPs),Zhangjiang Lab,China for providing technical support.
文摘The quality of traditional Chinese medicine(TCM)prescriptions(TCMPs)is critical to clinical efficacy;however,evaluating their consistency and identifying sources of variability remain challenging.This study proposes an integrated strategy to assess the quality of 100 widely sold TCMPs.A"one-for-all"chromatographic method was employed to analyze 645 sample batches.This large-scale data collection enabled statistical evaluations,such as hierarchical cluster analysis(HCA)and similarity heatmap,to identify quality inconsistencies.The introduction of a TCM-specific mass spectrometry(MS)database allowed for rapid,automated annotation of chemicals across 100 prescriptions and facilitated the tracing of raw material sources.Results indicate that 19%of prescriptions exhibited chemical inconsistencies,which are associated with high market value,low pricing,and substantial price disparities.The MS database allowed rapid annotation of 761 and 673 compounds in positive and negative modes,respec-tively,in 100 TCMPs,with 73 prescriptions reported for the first time.The tracing efforts succeeded in identifying>40%of the raw material sources for 51 prescriptions.P93(Yinianjin(YNJ))is a case in which the chromatographic profiles from three manufacturers displayed inconsistencies.Analysis using the database traced divergent peaks to Rhei Radix et Rhizoma(RRER).Verification with self-prepared samples confirmed that manufacturers utilized three distinct botanical sources.This integrated strategy provides a scalable framework for quality control in TCMPs.
文摘The significance of apoptosis in gastric cancer is now widely recognized, and the induction of apoptosis as a new approach to treat gastric cancer has aroused great interest. In recent years, studies on certain TCM drugs for treating gastric cancer and for inducing apoptosis have brought about great attention both at home and abroad. The following is a summary made in this aspect.
文摘Objective: To evaluate the clinical effect and quality of life (QOL) in coronary artery bypass grafting (CABG) patients treated according to syndrome differentiation of TCM. Methods: Eighty-two CABG patients were allocated in the control group (n = 39) treated with conventional method of western medicine, and the TCM-treated group (n
文摘The ideal hypotensive agent should possess three essentials, i.e. to depress the blood pressure surely and steadily, and to block the renin-angio-tensin system (RAS)(1). Currently, Western medical treatment could depress the blood pressure rapidly and surely through reducing blood volume and dilating blood vessels, while traditional Chinese medicine (TCM) shows its superiorities in al-
文摘Acupuncture at the Taichong (LR 3), Sanyinjiao (SP 6) and Ciliao (BL 32) points combined with TCM drugs for soothing the liver, replenishing the kidney, freeing the seminal passage, and eliminating the stasis showed effective for functional retrograde ejaculation in 25 cases. The total effective rate of 68.0% was significantly better than imipramine used in the control group (P<0.05).
文摘A Spanish businessman becomes a dedicated advocate of traditional Chinese medicine after witnessing its effects in treating his terminally ill young son.MY relationship with traditional Chinese medicine(TCM)-and with China-began in 1988,when I traveled to Beijing with my two-year-old son Joan.He was suffering from an extremely rare disease called leukoencephalopathy,in which the brain is affected,and we wanted to explore treatment possibilities.
文摘Parkinson's disease (PD) is a chronic degenerative disease of the nervous system marked by tremor,muscle rigidity, hypokinesis, abnormal posture, and pathologically, selective loss of dopaminergic neurons in the substantia nigra of the midbrain and obvious decrease of dopamine content in the striatum.It is encountered mostly in the middle-aged and old persons and is one of main causes inducing their deformity. The morbidity of this disease tends to increase with gradual aging of the population. In recent years, TCM treatment of this disease has obtained gratifying achievements. A review follows.
基金the Scientific Research Foundation of Sichuan Provincial Education Department(11ZA065:Scleral TGF-b1 expression in guinea pigs with form-deprivation myopia is altered in response to invigoration spleen and elimination blood stasis)the Department of Public Health Foundation,Sichuan Province(110527:Study on FDM guinea pig scleral fibroblasts TGFb1/Smad3 signaling pathway)the Science and Technology Development Foundation of the Teaching Hospital of Chengdu University of TCM(2012-D-YY-12:Research on FDM:guinea pig retinal function is altered in response to nourishing Xu and removing blood stasis).
文摘Objective:To explore whether the traditional Chinese medicine(TCM)Bu Jing Yi Shi Tablets alters the expression of scleral TGF-b1 and Smad3 in guinea pigs with formdeprivation myopia(FDM).Methods:Sixty-five guinea pigs were randomly divided into control,model,low-,medium-,and high-dose treatment groups.Except for the control group,FDM was induced by covering the right eye of each animal with opaque latex.The treatment groups were gavaged with different suspension concentrations of Bu Jing Yi Shi Tablets.Refraction and axial length were performed before and after myopia induction.At the end of the experiment,all right eyes were extracted,and scleral sections were prepared for staining and TGF-b1 and Smad3 immunohistochemistry.Scleral thickness and area,the scleral fibroblast quantity,and scleral TGFb1 and Smad3 expressions were measured.Results:The 5 FDM groups had the same initial axial length and diopter,the final diopter and axial length of the model group were significantly increased compared with the control group and treatment groups(P<.01).The axial length of each treatment group decreased as the dose decreased compared with the model group(P<.01);the total scleral area(P<.05 e.01)and the number of scleral fibroblasts(P<.01)in the model group were significantly lower than the treatment groups.Both the TGF-b1 and Smad3 integral optical densities in the model group were significantly lower than the control and medium-and high-dose treatment groups(P<.01).TGF-b1 and Smad3 mRNAs in the model group were decreased compared with the control group,but increased in expression after treatment.
基金supported by the Key Research and Development Program of Shaanxi(No.2019ZDLSF04-05)the National Natural Science Foundation of China(No.81974522),the Subject Innovation Team of Shaanxi University of Chinese Medi-cine(No.2019-YL10)the Youth Innovation Team of Shaanxi Universities(2020).
文摘TCM formulae are the important guidances for clinical application of traditional Chinese medicines,which follow the principles of diagnosis and treatment in TCM.Elucidating the bio-active components of TCM formulae is the key to the modernization and internationalization of traditional Chinese medicines.With the rapid development of modern instruments and technology,many new theories,methods and strategies are emerging,which upgrade the research of TCM formulae into a higher level.Only when the medicinal efficacy,bio-active components,function mechanism of TCM formulae are understood,we can guarantee TCM safety and quality control.In this paper,we summarized the latest modern research thoughts and methods on bio-active components of TCM formulae including formula decomposition study,serum pharmacology and serum pharmacochemistry,association analysis,biochro-matography,network pharmacology,metabolomics and proteomics,so as to provide reference for the research and development of TCM in the future.
文摘Microcirculatory changes and therapeutic effects in 39 non-insulin dependent diabetes mellitus (NIDDM) cases were evaluated. Under the same basic treatment in both groups, the treatment group (21 cases) was treated with TCM drugs according to its stages and compared with the control group (18 cases, treated with 654-2). The results showed that the microcirculatory cumulative scores were significantly decreased in both groups (P<0.05), but the decrease in the treatment group was more marked (P<0.05). In the treatment group, 15 cases were cured, 3 markedly effective, 2 effective and 1 ineffective; while in the control group, 13 cases were cured, 1 markedly effective and 4 ineffective. Statistically, there is no significant difference between the 2 groups (P>0.05) in therapeutic effects.
基金Supported by the National Fund Supporting Project of Natural Science (No.30772695)National Supporting Plan for Science and Technology in "The 11th Five-year Plan" (No.2006 BAI08B01-05)National Major Special Subject of Science and Technology (No.2009ZX10005-019)
文摘Objective: To simplify the TCM pattern of the zang-fu organs. Methods: A database of zang-fu syndromes was established. The relationship between the zang-fu syndromes was analyzed by means of frequency analysis, association rule, and ф-coefficient correlation. Results: The six zang-fu organs of the heart, liver, spleen, lung, kidney, and stomach prove to be the main components of the zang-fu pattern. The large intestine, small intestine, gallbladder, bladder, triple energizer, and pericardium have strong association and positive correlation with the above-mentioned six zang-fu organs, and their clinical symptoms can all be included into the symptoms of these six zang-fu organs. Conclusion: The traditional TCM pattern of six-zang and six-fu can be simplified into five-zang and one-fu.
文摘Objective: To study the distribution and development rules of the TCM syndromes in psoriasis vulgaris. Methods: Based on the clinical epidemiologic mass survey, the study was carried out by means of a status survey, multi-center and large-sample research. The data base was set up by EPIINFO6.0. The SPSS was used to do the statistical analyses in 2651 cases of psoriasis vulgaris to study the correlations among the distribution and development of the TCM syndromes, the stages of the disease, nationality, psoriasis history, family history, smoking history, alcohol drinking history, and severity of the disease. Results: The TCM syndromes in psoriasis vulgaris mainly include the blood-heat syndrome (53.8%), blood-dryness syndrome (27.4%), and blood-stasis syndrome (18.1%). Other syndromes were rarely seen, covering 0.6%. The concurrent syndromes mainly involve dampness, heat, blood stasis and toxin. The distribution differences of the main syndromes at different stages of the disease had statistical significance (P<0.01). The syndrome distribution is not related with nationality and family history (P>0.05), but it was closely related with the psoriasis history, smoking history, alcohol drinking history, and severity of the disease (P<0.01). Conclusion: At the initial stage, psoriasis vulgaris usually manifests itself as the blood-heat syndrome, and later it may be improved or turn into the blood-dryness or blood-stasis syndrome. Smoking, alcohol consumption, and severity of the disease may play a role in the syndrome's transformation.
文摘Objective: To discuss the relationship between the postoperative breast cancer with distant metastasis and the TCM syndromes classification. Methods: 160 postoperative 5-year breast cancer patients from 1995 to 2000 were tracked, summed up and analysized TCM syndromes as stagnation of hepatic qi, deficiency of spleen and pathogenic phlegm reten- tion, blood stasis and toxin stagnation, deficiencies of both blood and qi. Results: (1) For blood stasis and toxin stagnation TCM syndrome, the metastatic rate raised to 45% during 5 years. However, the metastatic rates of other three TCM syn- dromes are 15%, 17.5% and 22.5% respectively. The general distant metastasis rate was 27.5% (P<0.01). (2) Lymph node metastasis, tumor size, Her-2 and its receptor have no obvious relation with TCM syndromes classification (P>0.05). Conclu- sion: (1) TCM syndrome classification has close relation with breast cancer distant metastasis. Distant metastasis have close relationship with blood stasis and toxin stagnation syndrome. (2) Lymph node metastasis, tumor size, Her-2 and its receptor have no obvious relation with TCM syndromes classification, which suggested that metastatic ability has been programmed in the early stage of carcinoma initiation. (3) Significantly enlightening for predict the prognosis under the guide of TCM syn- drome classification and take right therapeutic strategy: attack pathogen and activate blood circulation against cancer.
基金Supported by Suzhou Science&Technology Plan Project(SKJY2021134,SYSD2020217,SYSD2019242)the Ninth Batch of Suzhou Gusu Key Health Talents Project(GSWS2022107)。
文摘[Objectives]To analyze the characteristics and rules of traditional Chinese medicine(TCM)in the treatment of decreased ovarian reserve(DOR)in Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine.[Methods]A total of 107 patients with DOR in Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine were selected for sorting,and the usage,classification,nature,taste and meridian homing of the used drugs were statistically analyzed.[Results]A total of 107 patients were included in this stud and a total of 189 flavors of TCM are used.The total frequency of drugs was 4345 times,and a total of 535 prescriptions were issued.The top five frequency of drug use were 2261 times(50.04%)of Paeoniae Radix Alba(Cynanchum otophyllum Schneid.),2037 times(46.88%)of Corni Fructus(Cornus officinalis Sieb.et Zucc.),1818 times(41.84%)of Rehmanniae Radix Praeparata[Rehmannia glutinosa(Gaertn.)Libosch EX Fisch.et Mey.],1610 times(37.05%)of Guiban[Chinemys reevesii(Gray)],and 1303 times(29.99%)of Uncariae Ramulus Cum Uncis(Uncariar hynchophylla Miq.ex Havil.).Kidney deficiency syndrome accounted for the largest proportion at 51.40%,and the use frequency of tonic drugs accounted for the highest at 50.64%;heat-clearing drugs and qi and blood-boosting drugs separately accounted for 19.24%and 17.39%;the top 3 medicinal tastes are sweet(52.02%),pungent(20.71%)and bitter(20.32%);medicinal properties are ranked as warm(60.54%),cold(24.16%),hot(8.72%)and cool(6.49%);the main meridians are spleen,lung,liver,stomach and kidney.[Conclusions]The basic pathogenesis of DOR is deficiency of qi and blood,mainly due to dysfunction of the spleen,lung,liver,liver,stomach and other organs,and kidney deficiency and spleen deficiency are more common.
基金supported by the Capital Medical Development Fund (Traditional Chinese Medicine Category) (No.SF-2007П07)
文摘Objective: To evaluate the short-term therapeutic effects of TCM for IgA nephropathy in children. Methods: Sixty-two children with primary IgA nephropathy diagnosed for the first time by renal biopsy in the authors’ hospital were randomly divided into a group of 34 cases treated with both TCM and Western medicine and a group of 28 cases treated with Western medicine for six months. The improvements in urinary protein and red blood cell (RBC) were observed and the scores for TCM symptoms and signs were evaluated after 3 months and 6months of treatment. Results: There was no significant difference in the total effective rate between the two groups (χ2=4.743, P>0.05 after treatment for 3 months; and χ2=1.953, P>0.05 after treatment for 6 months). However, the cure plus marked effect rate in the group treated with both TCM and Western medicine was higher than that in the group treated with Western medicine (71.9% vs 45.5%, P<0.05 after treatment for 3 months). At the end of treatment, significant difference were found in the effective rate (9.3% vs 10.5%, χ2=9.653, P<0.01) and in the total score (0.81+1.18 vs 3.42+2.52,t=4.19, P<0.001) between the two groups. Conclusion: Treatment with both TCM and Western medicine can effectively improve the TCM symptoms and signs in child patients with IgA nephropathy, and alleviate hematuria and albuminuria.
文摘The therapeutic effects in treating the intermediate and late rheumatoid arthritis by supplementing the kidney and invigorating blood circulation were observed. In the 43 cases of the treatment group, No. 2 Qu Feng Shi Ling capsules (祛风湿灵胶囊2号) and Fenbid (芬必得) were prescribed, while in the 39 cases of the control group Lei Gong Teng Tablets (雷公藤总甙片) and Fenbid were given. The results showed that the total effective rate in the treatment group was more satisfactory than that in the control (P<0.05 or P<0.01). With less toxic effects, the former could better improve the local swelling and lower the blood viscosity.
基金Project of Research Plan of Traditional Chinese Medicine of Hebei Administration of Traditional Chinese Medicine(No.2019490)。
文摘Objective:To explore the effective prevention and treatment of portal hypertension(PH).Methods:A total of 220 patients who came to our hospital from March 2015 to October 2018 were treated.They were randomly divided into the treatment group and the control group,each with 110 cases.Before treatment,there was no significant differences in age,sex,clinical symptoms,signs,laboratory tests and color Doppler ultrasound related examinations between the 2 groups(P>0.05).Among them,the treatment group on the basis of traditional Chinese and Western medicine treatment in our hospital,the Qi-acupuncture therapy of TCM was added.The extra meridian acupoints along with acupoints were selected.The control group received conventional treatment with traditional Chinese and Western medicine in our hospital.Results:There were significant differences in clinical symptoms,signs and chemistry between groups after treatment(P<0.01).There were significant differences in test,color ultrasound related examination and so on(P<0.01).Those in the treatment group was significantly better than the control group(P<0.01).Conclusion:On the basis of the Qi-acupuncture therapy of TCM,selecting extra meridian acupoint and acupoints can effectively treat PH.
基金We thank all the volunteers for providing invaluable inquiry data.Supported by the National NaturalScience Foundation of China(81173199)the Key Discipline of Nation Administration of Traditional Chinese Medicine Diagnostics in Chinese Medicine.
文摘Objective:Inquiry occupies an important position in the Traditional Chinese Medicine(TCM)diagnostic methods.Observing the characteristics of inquiry symptoms and the correlation with TCM syndromes can determine the important guiding significance to build recognition model and diagnostic criteria of syndrome.Methods:In this study,we collected 3707 valid cases,analyzed the inquiry symptoms of patients with cardiovascular disease,then to explore the distribution of inquiry information and the correlation with TCM syndromes based on the methods,such as frequency analysis,expert score,and correlation analysis.Results:We found the symptoms of frequency analysis and expert symptom score all in the top 50,add up to 41.According to the results by correlation analysis,the correlation coefficient between each symptom and each syndrome are sorted from high to low,the same with the experts score to each inquiry symptom basing on its importance of in diagnosing each syndrome.Conclusion:Inquiry occupies an important effect in differentiation syndrome.This research could provide certain objective basis for establishment of TCM syndromes diagnostic criteria of cardiovascular disease,thus provide some ideas and methods for the research of establishing TCM syndrome identification model,then to provide a reference for the syndrome standardization and objectification.
