Objective:To study the possible effects of Cerithidea obtusa extract as antidiabetic and to screen the secondary metabolites presence.Methods:Antidiabetic activity of Cerithidea obtusa extract was measured in vitro us...Objective:To study the possible effects of Cerithidea obtusa extract as antidiabetic and to screen the secondary metabolites presence.Methods:Antidiabetic activity of Cerithidea obtusa extract was measured in vitro usingα-glucosidase inhibition method.Whereas,secondary metabolites screening was measured qualitatively.Results:The methanol extract had antidiabetic activity(IC_(50)=36.40 mg/mL).However,the control drug acarbose had significantly higher antidiabetic activity(IC_(50)=0.32 mg/mL).Secondary metabolites screening showed the presence of alkaloids,flavonoids,triterpenoids and saponins.Conclusions:The methanol extract had antidiabetic activity and the presence of alkaloids,flavonoids and triterpenoids might contribute to the activity.展开更多
基金Supported by Directorate of Research and Community Service,Directorate General of Higher Education(DIKTI),Ministry of Education and Culture of Indonesia.
文摘Objective:To study the possible effects of Cerithidea obtusa extract as antidiabetic and to screen the secondary metabolites presence.Methods:Antidiabetic activity of Cerithidea obtusa extract was measured in vitro usingα-glucosidase inhibition method.Whereas,secondary metabolites screening was measured qualitatively.Results:The methanol extract had antidiabetic activity(IC_(50)=36.40 mg/mL).However,the control drug acarbose had significantly higher antidiabetic activity(IC_(50)=0.32 mg/mL).Secondary metabolites screening showed the presence of alkaloids,flavonoids,triterpenoids and saponins.Conclusions:The methanol extract had antidiabetic activity and the presence of alkaloids,flavonoids and triterpenoids might contribute to the activity.
