The 7 ka old Qixiangzhan lava flow(QXZ,Tianchi volcano)represents the last eruptive event before the 946 CE,caldera-forming‘Millennium’eruption(ME).Petrographic,whole rock,mineral composition,Sr-Nd isotopic data on ...The 7 ka old Qixiangzhan lava flow(QXZ,Tianchi volcano)represents the last eruptive event before the 946 CE,caldera-forming‘Millennium’eruption(ME).Petrographic,whole rock,mineral composition,Sr-Nd isotopic data on QXZ show that:(a)the lava consists of two components,constituted by comenditic obsidian fragments immersed in a continuous,aphanitic component;(b)both components have the same geochemical and isotopic variations of the ME magma.The QXZ and ME comendites result from fractional crystallization and crustal assimilation processes.The temperature of the QXZ magma was about 790℃ and the depth of the magma reservoir around 7 km,the same values as estimated for ME.QXZ had a viscosity of 10^(5.5)-10^(9) Pa s and a velocity of 3-10 km/yr.The emplacement time was 0.5-1.6yr and the flow rate 0.48-1.50 m^(3)/s.These values lie within the range estimated for other rhyolitic flows worldwide.The QXZ lava originated through a mixed explosive-effusive activity with the obsidian resulting from the ascent of undercooling,degassing and the fragmentation of magma along the conduit walls,whereas the aphanitic component testifies to the less undercooled and segregated flow at the center of the conduit.The QXZ lava demonstrates the extensive history of the ME magma chamber.展开更多
Hypoxic pulmonary hypertension(HPH)is a pathophysiological state characterized by diverse clinical symptoms resulting from structural and functional changes in pulmonary vessels induced by hypoxic stimuli,leading to i...Hypoxic pulmonary hypertension(HPH)is a pathophysiological state characterized by diverse clinical symptoms resulting from structural and functional changes in pulmonary vessels induced by hypoxic stimuli,leading to increased pulmonary artery pressure.展开更多
Digital rock analysis(DRA)is fundamental for geo-energy research,enabling the characterisation of microstructures for applications like hydrocarbon recovery,carbon storage,and groundwater modelling.Although 2D CT imag...Digital rock analysis(DRA)is fundamental for geo-energy research,enabling the characterisation of microstructures for applications like hydrocarbon recovery,carbon storage,and groundwater modelling.Although 2D CT images provide valuable pore-scale data,the scarcity of real-world datasets limits the effectiveness of advanced analysis.Generative AI presents a promising approach for synthesizing high-quality rock images but faces key challenges,including high computational demands,insufficient evaluation metrics,and the trade-off between image fidelity and diversity.To address these limitations,this study proposes the use of Low-Rank Adaptation(LoRA)for fine-tuning stable diffusion models,significantly reducing computational requirements while maintaining image quality.A systematic investigation was conducted to evaluate the influence of LoRA training parameters,including rank and learning rate,on the quality of generated images.Image outputs were assessed using both standard generative metrics,such as Kernel Inception Distance(KID),and domain-specific metrics,including porosity,pore count,and pore area distributions.The optimised LoRA-enhanced diffusion model achieved a 92.6% reduction in KID relative to baseline models,while also improving inference speed.Building on these advancements,this study demonstrates that the LoRA-enhanced diffusion model significantly improves neural network extrapolation in incomplete data scenarios through statistically consistent synthetic generation.Despite control challenges,this approach reduces costs and enables diverse applications,bridging fundamental rock physics with practical energy research.展开更多
Vision restoration presents a considerable challenge in the realm of regenerative medicine,while recent progress in ultrasound stimulation has displayed potential as a non-invasive therapeutic approach.This narrative ...Vision restoration presents a considerable challenge in the realm of regenerative medicine,while recent progress in ultrasound stimulation has displayed potential as a non-invasive therapeutic approach.This narrative review offers a comprehensive overview of current research on ultrasound-stimulated neuromodulation,emphasizing its potential as a treatment modality for various nerve injuries.By examining of the efficacy of different types of ultrasound stimulation in modulating peripheral and optic nerves,we can delve into their underlying molecular mechanisms.Furthermore,the review underscores the potential of sonogenetics in vision restoration,which involves leveraging pharmacological and genetic manipulations to inhibit or enhance the expression of related mechanosensitive channels,thereby modulating the strength of the ultrasound response.We also address how methods such as viral transcription can be utilized to render specific neurons or organs highly responsive to ultrasound,leading to significantly improved therapeutic outcomes.展开更多
As the mining industry continues to expand and international oil prices increase,more rigorous demands are being placed on the design of mining equipment.Given this,there is an urgent need to develop new power-driven ...As the mining industry continues to expand and international oil prices increase,more rigorous demands are being placed on the design of mining equipment.Given this,there is an urgent need to develop new power-driven mining equipment to solve the problems of high energy consumption and insufficient power coupling of current equipment.This study proposed a design of a hybrid power system for underground Load Haul Dump(LHD).The proposed design integrated Quality Function Deployment(QFD)and Theory of Inventive Problem Solving(TRIZ).It identified 7 user requirements and 10 related technical features,formulated 11 innovative design solutions,and ultimately adopting an electric drive hybrid power scheme.This scheme effectively addressesd power transmission coupling problems and improve the efficiency of loaders.A 6 m³hybrid power loader prototype has been developed,which reduces operational energy consumption and advances the electrification and green,low-carbon evolution of mining equipment.展开更多
OBJECTIVE:To illustrate the effect of add-on therapy of Traditional Chinese Medicine(TCM)on the long-term survival of anemic lower-risk myelodysplastic syndromes(LR-MDS)patients.METHODS:In this study,we conducted a re...OBJECTIVE:To illustrate the effect of add-on therapy of Traditional Chinese Medicine(TCM)on the long-term survival of anemic lower-risk myelodysplastic syndromes(LR-MDS)patients.METHODS:In this study,we conducted a retrospective analysis of the data of patients with LR-MDS who were identified from Shuguang Hospital between January 2006 and June 2020.The Kaplan-Meier method was used to calculate overall survival(OS),while the Cox model was employed to analyze prognostic factors of long-term survival.A total of 162 patients who met the inclusion criteria were divided into two groups:the TCM group(n=78)or the non-TCM group(n=84).RESULTS:There were no significant differences in baseline characteristics.The cumulative survival rate of the TCM group was significantly higher than that of the non-TCM group[log-rank P=0.029,hazard ratio(HR)=0.484,95%confidence interval(CI)(0.249,0.942),P<0.05].Patients with longer TCM treatment appeared to have better OS(≥12 months vs<12 months);[HR,0.16695%CI(0.055,0.508),P<0.001].According to the Cox model analysis,the combination of TCM and conventional Western Medicine may be a protective factor affecting the long-term survival of LR-MDS patients[HR=0.509,95%CI,(0.261,0.993),P=0.048].The hematologic improvement erythroid response(HI-E)rate of the TCM group was significantly higher than that of the non-TCM group(69.23%vs 52.38%;P=0.028).However,the duration of HI-E and cases of disease progression after HI-E did not significantly differ from the non-TCM group(P>0.05).CONCLUSIONS:The integration of TCM and Western Medicine has the potential to extend the OS of LR-MDS patients when compared to the use of Western Medicine alone.展开更多
Capsaicin-containing polymer materials with functional structure were successfully prepared by simple free radical poly-merization of capsaicin functional monomers(Poly(AMTHBA-co-NVP))with 1-vinyl-2-pyrrolidone.Compar...Capsaicin-containing polymer materials with functional structure were successfully prepared by simple free radical poly-merization of capsaicin functional monomers(Poly(AMTHBA-co-NVP))with 1-vinyl-2-pyrrolidone.Compared with pure capsaicin polymer,the adsorption content of the obtained Poly(AMTHBA-co-NVP)increased by more than 3 times,which has huge potential research value.The composition and morphology of Poly(AMTHBA-co-NVP)before and after adsorption were analyzed using XRD,FT-IR,XPS,SEM and TEM.The mechanism of the adsorption process was summarized,through the study of the optimal molar ratio of reactants,acid-base environment,adsorption model fitting,characterization data results,and pollutant competition experiments.The following conclusions can be drawn:1)The pseudo-second-order kinetic model better matches the adsorption kinetics of partial Cr(VI).2)Part of the restored Cr(III)is trapped by specific groups on Poly(AMTHBA-co-NVP)and part of the Cr(III)is released back into solution.3)The adsorption mechanism includes ion exchange,coordination and chemical bonding.4)The highest adsorp-tion capacity of the polymeric material was up to 370.59 mg/g when the molar ratio of reactants was AMTHBA:NVP=2:8.This work not only provides ideas for the synthesis of capsaicin structural and functional polymers,but also provides inspiration for wastewater treatment measures.展开更多
Cenozoic trachytes are characteristic of some active volcanic fields in China.In particular,the origin and mechanisms of the evolution of trachytes from the Tianchi(Changbaishan)volcano(TV,China/North Korea)are poorly...Cenozoic trachytes are characteristic of some active volcanic fields in China.In particular,the origin and mechanisms of the evolution of trachytes from the Tianchi(Changbaishan)volcano(TV,China/North Korea)are poorly known.Here,we present new geochronological,geochemical and isotopic data on two trachytic suites outcropping on the northern and southern upper slopes of TV.Detailed zircon laser ablation-multicollector-inductively coupled plasma-mass spectrometry(LA-MC-ICP-MS)U-Pb dating,Rb-Sr isochron dating of plagioclase and hornblende,^(40)Ar/^(39)Ar chronology with mineral chemistry,whole-rock element and Sr-Nd-Pb isotope data are used to explore their origins and evolutionary mechanisms during the late Middle Pleistocene.Our data indicate that the trachytes mainly consist of sanidine,orthoclase and plagioclase,with minor albite,quartz and hornblende.They formed at 0.353-0.346 Ma(lava flow from the northern slope)and 0.383-0.311 Ma(lava flow from the southern slope),respectively.The TV trachytes are characterized by high K_(2)O/Na_(2)O and AR values,with low A/CNK and Mg~#values.They are enriched in rare earth elements(REEs;except Eu),depleted in Sr and Ba,crystallizing at 742-858℃.The TV trachytes have high(^(87)Sr/^(86)Sr)_i values(0.70776-0.71195),positiveε_(Nd)(t)values(0.61-2.93)and radiogenic^(206)Pb/^(204)Pb values(17.515-17.806).These values are similar to those of the Pleistocene and Holocene TV trachytes.Geochemical data indicate that they were formed by fractional crystallization from a basaltic melt and assimilated upper crust material.The trace element pattern of the studied trachytes is consistent with an evolution from basaltic melts representative of an enriched mantle source.The vent from which the trachytic magma was erupted probably collapsed inside the caldera during the TV'Millennium'eruption(ME)in 946 AD.The contemporaneous emission of basaltic and trachytic magma during the Middle-Late Pleistocene suggests the coexistence of fissural basaltic volcanism and central-type trachytic volcanism,the latter of which was associated with a magma chamber in the upper crust during the TV cone-construction stage.展开更多
基金funded by the National Natural Science Foundation of China(Grant Nos.41972313 and 41790453)the Engineering Research Center of Geothermal Resources Development Technology and Equipment,Ministry of Education,Jilin University。
文摘The 7 ka old Qixiangzhan lava flow(QXZ,Tianchi volcano)represents the last eruptive event before the 946 CE,caldera-forming‘Millennium’eruption(ME).Petrographic,whole rock,mineral composition,Sr-Nd isotopic data on QXZ show that:(a)the lava consists of two components,constituted by comenditic obsidian fragments immersed in a continuous,aphanitic component;(b)both components have the same geochemical and isotopic variations of the ME magma.The QXZ and ME comendites result from fractional crystallization and crustal assimilation processes.The temperature of the QXZ magma was about 790℃ and the depth of the magma reservoir around 7 km,the same values as estimated for ME.QXZ had a viscosity of 10^(5.5)-10^(9) Pa s and a velocity of 3-10 km/yr.The emplacement time was 0.5-1.6yr and the flow rate 0.48-1.50 m^(3)/s.These values lie within the range estimated for other rhyolitic flows worldwide.The QXZ lava originated through a mixed explosive-effusive activity with the obsidian resulting from the ascent of undercooling,degassing and the fragmentation of magma along the conduit walls,whereas the aphanitic component testifies to the less undercooled and segregated flow at the center of the conduit.The QXZ lava demonstrates the extensive history of the ME magma chamber.
基金supported by General Program of the Natural Science Foundation of Hebei Province(No.H2024110033,China).
文摘Hypoxic pulmonary hypertension(HPH)is a pathophysiological state characterized by diverse clinical symptoms resulting from structural and functional changes in pulmonary vessels induced by hypoxic stimuli,leading to increased pulmonary artery pressure.
基金funding from Innovate UK(reference number:10003208)the China Scholarship Council(Grant No.CSC 202408420030).
文摘Digital rock analysis(DRA)is fundamental for geo-energy research,enabling the characterisation of microstructures for applications like hydrocarbon recovery,carbon storage,and groundwater modelling.Although 2D CT images provide valuable pore-scale data,the scarcity of real-world datasets limits the effectiveness of advanced analysis.Generative AI presents a promising approach for synthesizing high-quality rock images but faces key challenges,including high computational demands,insufficient evaluation metrics,and the trade-off between image fidelity and diversity.To address these limitations,this study proposes the use of Low-Rank Adaptation(LoRA)for fine-tuning stable diffusion models,significantly reducing computational requirements while maintaining image quality.A systematic investigation was conducted to evaluate the influence of LoRA training parameters,including rank and learning rate,on the quality of generated images.Image outputs were assessed using both standard generative metrics,such as Kernel Inception Distance(KID),and domain-specific metrics,including porosity,pore count,and pore area distributions.The optimised LoRA-enhanced diffusion model achieved a 92.6% reduction in KID relative to baseline models,while also improving inference speed.Building on these advancements,this study demonstrates that the LoRA-enhanced diffusion model significantly improves neural network extrapolation in incomplete data scenarios through statistically consistent synthetic generation.Despite control challenges,this approach reduces costs and enables diverse applications,bridging fundamental rock physics with practical energy research.
基金supported by R01EY032229(Biomechanical Mapping of the Optic Nerve Head and Peripapillary Sclera Using High Frequency Ultrasonic Elastography)R01EY028662(High-resolution Elastographic Assessment of the Optic Nerve Head)+2 种基金R01EY030126(Non-invasive Ultrasound Stimulated Retinal Prosthesis)(to QZ)Unrestricted Grant to the Department of Ophthalmology from Research to Prevent Blindness,New York,NY(to MSH)the National Eye Institute of the National Institutes of Health under Award Number P30EY029220(to MSH)。
文摘Vision restoration presents a considerable challenge in the realm of regenerative medicine,while recent progress in ultrasound stimulation has displayed potential as a non-invasive therapeutic approach.This narrative review offers a comprehensive overview of current research on ultrasound-stimulated neuromodulation,emphasizing its potential as a treatment modality for various nerve injuries.By examining of the efficacy of different types of ultrasound stimulation in modulating peripheral and optic nerves,we can delve into their underlying molecular mechanisms.Furthermore,the review underscores the potential of sonogenetics in vision restoration,which involves leveraging pharmacological and genetic manipulations to inhibit or enhance the expression of related mechanosensitive channels,thereby modulating the strength of the ultrasound response.We also address how methods such as viral transcription can be utilized to render specific neurons or organs highly responsive to ultrasound,leading to significantly improved therapeutic outcomes.
文摘As the mining industry continues to expand and international oil prices increase,more rigorous demands are being placed on the design of mining equipment.Given this,there is an urgent need to develop new power-driven mining equipment to solve the problems of high energy consumption and insufficient power coupling of current equipment.This study proposed a design of a hybrid power system for underground Load Haul Dump(LHD).The proposed design integrated Quality Function Deployment(QFD)and Theory of Inventive Problem Solving(TRIZ).It identified 7 user requirements and 10 related technical features,formulated 11 innovative design solutions,and ultimately adopting an electric drive hybrid power scheme.This scheme effectively addressesd power transmission coupling problems and improve the efficiency of loaders.A 6 m³hybrid power loader prototype has been developed,which reduces operational energy consumption and advances the electrification and green,low-carbon evolution of mining equipment.
基金China Academy of Chinese Medical Sciences Innovation Fund:Precise Positioning Decision-making Platform for Clinical Trials of Traditional Chinese Medicine Based on Predicition Model(CI2021A04707)The Fundamental Research Funds for the Central Public Welfare Research Institutes:Research on Traditional Chinese Medicine Syndrome Differentiation-based a Bayesian Decision Model of Basket Trial(ZZ13-YQ-076)+1 种基金The Fifth Batch of National TCM Clinical Outstanding Talent Training ProgramThe Fund of National Natural Science Foundation of China(Youth Science):Effect of Compound Shenlu Granule on Apoptosis of CD34+Cells in Lower-risk Myelodysplastic Syndromes Bone Marrow based on p38 Mitogen-activated Protein Kinase Pathway(81403233)。
文摘OBJECTIVE:To illustrate the effect of add-on therapy of Traditional Chinese Medicine(TCM)on the long-term survival of anemic lower-risk myelodysplastic syndromes(LR-MDS)patients.METHODS:In this study,we conducted a retrospective analysis of the data of patients with LR-MDS who were identified from Shuguang Hospital between January 2006 and June 2020.The Kaplan-Meier method was used to calculate overall survival(OS),while the Cox model was employed to analyze prognostic factors of long-term survival.A total of 162 patients who met the inclusion criteria were divided into two groups:the TCM group(n=78)or the non-TCM group(n=84).RESULTS:There were no significant differences in baseline characteristics.The cumulative survival rate of the TCM group was significantly higher than that of the non-TCM group[log-rank P=0.029,hazard ratio(HR)=0.484,95%confidence interval(CI)(0.249,0.942),P<0.05].Patients with longer TCM treatment appeared to have better OS(≥12 months vs<12 months);[HR,0.16695%CI(0.055,0.508),P<0.001].According to the Cox model analysis,the combination of TCM and conventional Western Medicine may be a protective factor affecting the long-term survival of LR-MDS patients[HR=0.509,95%CI,(0.261,0.993),P=0.048].The hematologic improvement erythroid response(HI-E)rate of the TCM group was significantly higher than that of the non-TCM group(69.23%vs 52.38%;P=0.028).However,the duration of HI-E and cases of disease progression after HI-E did not significantly differ from the non-TCM group(P>0.05).CONCLUSIONS:The integration of TCM and Western Medicine has the potential to extend the OS of LR-MDS patients when compared to the use of Western Medicine alone.
基金supported by the National Natural Sci-ence Foundation of China(No.U22A20112)the Hainan Provincial Natural Science Foundation(No.522CXTD520)the Key Research and Development Project of Hainan Province(No.ZDYF2021GXJS029).
文摘Capsaicin-containing polymer materials with functional structure were successfully prepared by simple free radical poly-merization of capsaicin functional monomers(Poly(AMTHBA-co-NVP))with 1-vinyl-2-pyrrolidone.Compared with pure capsaicin polymer,the adsorption content of the obtained Poly(AMTHBA-co-NVP)increased by more than 3 times,which has huge potential research value.The composition and morphology of Poly(AMTHBA-co-NVP)before and after adsorption were analyzed using XRD,FT-IR,XPS,SEM and TEM.The mechanism of the adsorption process was summarized,through the study of the optimal molar ratio of reactants,acid-base environment,adsorption model fitting,characterization data results,and pollutant competition experiments.The following conclusions can be drawn:1)The pseudo-second-order kinetic model better matches the adsorption kinetics of partial Cr(VI).2)Part of the restored Cr(III)is trapped by specific groups on Poly(AMTHBA-co-NVP)and part of the Cr(III)is released back into solution.3)The adsorption mechanism includes ion exchange,coordination and chemical bonding.4)The highest adsorp-tion capacity of the polymeric material was up to 370.59 mg/g when the molar ratio of reactants was AMTHBA:NVP=2:8.This work not only provides ideas for the synthesis of capsaicin structural and functional polymers,but also provides inspiration for wastewater treatment measures.
基金financially supported by the project of the National Observation and Research Station of the Institute of Geology,China Earthquake Administration(Grant No.NORSCBS22-06)the Youth Science and Technology Development Project of the Jilin Earthquake Agency(Grant No.JZQ-202402)+1 种基金the Earthquake Science and Technology Spark Project(Grant No.XH23013B)the China Scholarship Council(Grant No.202104190014)。
文摘Cenozoic trachytes are characteristic of some active volcanic fields in China.In particular,the origin and mechanisms of the evolution of trachytes from the Tianchi(Changbaishan)volcano(TV,China/North Korea)are poorly known.Here,we present new geochronological,geochemical and isotopic data on two trachytic suites outcropping on the northern and southern upper slopes of TV.Detailed zircon laser ablation-multicollector-inductively coupled plasma-mass spectrometry(LA-MC-ICP-MS)U-Pb dating,Rb-Sr isochron dating of plagioclase and hornblende,^(40)Ar/^(39)Ar chronology with mineral chemistry,whole-rock element and Sr-Nd-Pb isotope data are used to explore their origins and evolutionary mechanisms during the late Middle Pleistocene.Our data indicate that the trachytes mainly consist of sanidine,orthoclase and plagioclase,with minor albite,quartz and hornblende.They formed at 0.353-0.346 Ma(lava flow from the northern slope)and 0.383-0.311 Ma(lava flow from the southern slope),respectively.The TV trachytes are characterized by high K_(2)O/Na_(2)O and AR values,with low A/CNK and Mg~#values.They are enriched in rare earth elements(REEs;except Eu),depleted in Sr and Ba,crystallizing at 742-858℃.The TV trachytes have high(^(87)Sr/^(86)Sr)_i values(0.70776-0.71195),positiveε_(Nd)(t)values(0.61-2.93)and radiogenic^(206)Pb/^(204)Pb values(17.515-17.806).These values are similar to those of the Pleistocene and Holocene TV trachytes.Geochemical data indicate that they were formed by fractional crystallization from a basaltic melt and assimilated upper crust material.The trace element pattern of the studied trachytes is consistent with an evolution from basaltic melts representative of an enriched mantle source.The vent from which the trachytic magma was erupted probably collapsed inside the caldera during the TV'Millennium'eruption(ME)in 946 AD.The contemporaneous emission of basaltic and trachytic magma during the Middle-Late Pleistocene suggests the coexistence of fissural basaltic volcanism and central-type trachytic volcanism,the latter of which was associated with a magma chamber in the upper crust during the TV cone-construction stage.
