Objectives:The aim of this study was to verify the causal relationship between trait aggressiveness(TA)and moral disengagement(MD),know more about the growth trajectory of MD,and explore the effects of gender and TA o...Objectives:The aim of this study was to verify the causal relationship between trait aggressiveness(TA)and moral disengagement(MD),know more about the growth trajectory of MD,and explore the effects of gender and TA on the growth trajectory.Methods:We used the Buss-Perry Aggression Questionnaire and Moral Disengagement Scale to survey 433 Chinese junior high school students longitudinally three times.Results:The results of the random intercept cross-lagged panel model(RI-CLPM)analysis indicated that TA positively predicted MD,while MD did not predict TA at the within-person level.Thus,TA could be considered an antecedent variable of MD.Furthermore,the unconditional latent growth linear model analysis revealed that MD among junior high school students exhibited an upward trend,characterized by an increasing rate of growth over time.In the conditional latent growth linear model analysis,we found that gender influenced only the initial level of MD but had no effect on its growth rate.Conversely,TA demonstrated both delayed and immediate positive effects on the growth of MD.Conclusions:Our findings suggested a one-way cross-lag effect between TA and MD.Additionally,the growth trajectory of MD among junior high school students was found to be ascending.This growth trajectory was influenced by gender and TA,offering valuable insights for the prevention and intervention of behavioral problems in junior high school students.展开更多
This research was to investigate the intervention effect of art-making on the anxiety symptoms of college students. A sample of 400college students took part in this research. They were assigned to the experiment grou...This research was to investigate the intervention effect of art-making on the anxiety symptoms of college students. A sample of 400college students took part in this research. They were assigned to the experiment group (n = 200) and the control group (n = 200)according to Self-Rating Anxiety Scale (SAS) scores. Unlike the control group, the experiment group received a standard artmaking program under the supervision of trained instructors for a period of twelve sessions two times weekly which wascontinued for six weeks. Self-Rating Anxiety Seale (SAS) and Hamilton Anxiety Scale (HAMA) were used to assess anxietysymptoms level. Significant decreases in anxiety symptoms (p < 0.05) were found in the experiment group compared with thecontrol group. Using the art-making program to relieve anxiety, the shortest intervention period is three weeks. Art-makingcan effectively alleviate college students’ anxiety, and also can effectively improve the physical health, mental health, and socialhealth levels of college students.展开更多
Objective: To identify the moderating effects of cognitive reappraisal(CR) and expressive suppression(ES) on the relationship between posttraumatic stress(PTS) symptoms and posttraumatic growth(PTG) in university stud...Objective: To identify the moderating effects of cognitive reappraisal(CR) and expressive suppression(ES) on the relationship between posttraumatic stress(PTS) symptoms and posttraumatic growth(PTG) in university students. Methods: The survey included 1 987 Chinese university students who completed questionnaires on PTS symptoms in February 2020, with three follow-up surveys at two-month intervals until August 2020. We assessed CR and ES at February 2020 and PTG at August 2020. Growth mixture modeling was used to classify the PTS symptom trajectories. Multinomial logistic regression was used to recognize the predictors of class membership. The relationships among PTS symptoms, CR, ES, and PTG were examined using multi-group path analysis.Results: Sex, SARS-Co V-2 infection of a family member or friend, number of siblings, CR, and ES were significantly associated with PTS symptoms. Three latent classes were identified: ‘Increasing PTS’(n=205, 10.0%) who had rapid deterioration of PTS symptoms, ‘Moderate PTS’(n=149, 8.0%) who had a high level of PTS symptoms at the beginning and slightly increasing, and ‘Persistent Minimal PTS’(n=1 633, 82.0%), who had slow resolution of PTS symptoms over time. Male, SARS-Co V-2 infection of a family member or friend, and having a lower CR and a higher ES, were more likely to have ‘Increasing PTS’. PTS at February 2020 predicted PTG only in ‘Increasing PTS’ class, and both CR and ES had moderating effects on the conversion between them.Conclusions: Most students recovered from posttraumatic stress of COVID-19 pandemic, but a small proportion expeienced increasing PTS symptoms, and those with this condition may benefit from emotional regulation intervention.展开更多
The report of the 19th communist party of China national congress on youth work provides theoretical support and practical guidance for the realization of the ideological value of college students in the new era.In th...The report of the 19th communist party of China national congress on youth work provides theoretical support and practical guidance for the realization of the ideological value of college students in the new era.In the new era,it is necessary to comprehensively and deeply study and judge the value situation of young students in colleges and universities,crack the problems and shortcomings faced by ideological and political work in colleges and universities,and explore effective educational paths in the practice of ideological and political work,so as to orderly realize the ideological value guidance of college students.展开更多
Public security colleges shoulder the responsibility of cultivating and transporting qualified policemen to public security institutions. They are the cradle cultivating police. Strengthening basic construction of pub...Public security colleges shoulder the responsibility of cultivating and transporting qualified policemen to public security institutions. They are the cradle cultivating police. Strengthening basic construction of public security colleges and universities ,combining each aspect management and teaching work thus forming a perfect management system is the cornerstone promoting long-term development of public security education undertakings. Since 2011, Students＇ Affairs Office of Criminal Police College of China has developed and implemented basic construction programs, starting with students organizations at grassroots level, achievinv better results. It has certain reference significance for improving student management work in public security colleges.展开更多
Through a case study of a college student experiencing anxiety,this paper elucidates the structured consultation process of cognitive behavioral therapy,highlighting the application,techniques,and outcomes of relevant...Through a case study of a college student experiencing anxiety,this paper elucidates the structured consultation process of cognitive behavioral therapy,highlighting the application,techniques,and outcomes of relevant consultation methods.The consultation aims to assist the client in overcoming challenges,improving emotional well-being,and reshaping thought patterns to achieve the desired therapeutic effects.展开更多
Amidst the unique challenges faced by rural educators is their sense of decent work influenced by levels of social support,career self-efficacy,and marginalization.To investigate these relationships,we surveyed 435 ru...Amidst the unique challenges faced by rural educators is their sense of decent work influenced by levels of social support,career self-efficacy,and marginalization.To investigate these relationships,we surveyed 435 rural school teachers(females=69.32%,mean years teaching experience=13.6,SD=7.7 years).The Structural Equation Modeling results indicated that social support positively predicts teachers’perceptions of decent work.Career self-efficacy mediated the relationship between social support and a higher sense of decent work,while marginalization mediated the relationship such that lower social support predicted lower perceptions of decent work.Career self-efficacy and marginalization also had a sequential mediation relationship:higher social support enhanced career self-efficacy,which in turn reduced marginalization experiences,ultimately improving teachers’perceptions of decent work.These findings align with the predictions of Social Cognitive Career Theory and the Psychology of Working Theory,demonstrating that environmental supports enhance personal psychological resources,reduce marginalization risks,and promote positive work-related outcomes.The study findings highlight the necessity for education departments to improve rural teachers’perceptions of decent work by providing social support to foster positive work experiences for teachers at high risk for marginalization and diminished career self-efficacy.展开更多
Objective:To examine the effects of coronavirus disease-2019(COVID-19)exposure,expressive suppression/cognitive reappraisal,and demographic variables on post-traumatic stress symptoms(PTS)among Chinese.Methods:Partici...Objective:To examine the effects of coronavirus disease-2019(COVID-19)exposure,expressive suppression/cognitive reappraisal,and demographic variables on post-traumatic stress symptoms(PTS)among Chinese.Methods:Participants were recruited by social media through We Chat and 6049 Chinese(aged from 17 to 63 years;median=24)from 31 provinces were included in the study.PTS symptoms,expressive suppression,and cognitive reappraisal were assessed after the outbreak of COVID-19.A regression mixture analysis was conducted in Mplus 7.Results:A regression mixture model identified three latent classes that were primarily distinguished by differential effects of COVID-19 exposures on PTS symptoms:(1)Class 1(mildly PTS symptoms,80.9%),(2)Class 2(moderate PTS symptoms,13.0%),and(3)Class 3(high PTS symptoms,6.1%).The results demonstrated that the young,women and people with responsibilities and concerns for others were more vulnerable to PTS symptoms;and they had more expression inhibition and less cognitive reappraisal in three latent classes.Conclusions:The findings suggest that more attention needs to be paid to vulnerable groups such as the young,women and people with responsibilities and concerns for others.Therapies to encourage emotional expression and increase cognitive reappraisal may also be helpful for trauma survivors.展开更多
In the context of the era of continuous development of artificial intelligence, the labor value of university students is impacted by technological substitution. Simultaneously, university students are also required t...In the context of the era of continuous development of artificial intelligence, the labor value of university students is impacted by technological substitution. Simultaneously, university students are also required to constantly update their skills. All of the above will be the challenge of university students’ employment prospects. However, artificial intelligence will also bring new opportunities, which will stimulate the innovation ability of university students and bring new directions for employment. In order to better cope with the possible impact of artificial intelligence, universities should incorporate employment guidance services into the “three-wide education” system. To achieve this, universities need to take the following measures: developing the dynamic monitoring system of university employment based on big data, constructing the employment guidance curriculum system of university students throughout the whole process, updating the mode of diversified employment guidance service as well as establishing a team of employment guidance teachers keeping pace with the times. These measures aim to better adapt to the job market demands in the context of artificial intelligence, guide students to actively respond to the possible impact of artificial intelligence technology, cultivate their core competencies and qualities that are less likely to be replaced by artificial intelligence, and promote the high-quality employment of university students.展开更多
Dispute upon the Taoist natural philosophical ethic value and the spreading and application of the ecological ethic customs in the academic circle blocks related research upon the ecological ethics of Taoist natural p...Dispute upon the Taoist natural philosophical ethic value and the spreading and application of the ecological ethic customs in the academic circle blocks related research upon the ecological ethics of Taoist natural philosophy.With regard to the two research focuses of the ecological ethics at present—the continuous development of the modern ecological protection and the wild value strategy of ecological maintenance,it is useful to excavate the development from ecological phenomenological cognition to ecological image system so as to provide a new perspective for research upon the Taoist philosophy;at the same time,having a better understanding of the significance of treating ecology as the ethnography is good for integrating the Taoist natural philosophy into ecological theories and developing the national ethical value.展开更多
Micro- injury （exercise-induced muscle damage, EIMD） will cause a temporary decline in muscle function, if not handled properly, it could cause more serious injury or overtraining, and even lead to the end of the at...Micro- injury （exercise-induced muscle damage, EIMD） will cause a temporary decline in muscle function, if not handled properly, it could cause more serious injury or overtraining, and even lead to the end of the athletes ＇ sports life. However, some studies have shown that an appropriate period of eccentric exercise training resulted in EIMD while promoted heart muscle fiber hypertrophy and corresponding muscle growth faster than exercise training, and there are the typical ＂ repetitive training effect＂ , ie after a period of the EIMD recovery, the muscle＇ s injury or delayed onset muscle soreness （DOMS） caused by the same movement is significantly reduced. So its deep study could help to guide the athlete to avoid or mitigate the negative effects which brought by EIMD, while could help to further clarify the process of the body to adapt to exercise training or mechanism.展开更多
Graduate course teaching plays an irreplaceable role in knowledge mastery,skill enhancement,and quality cultivation of graduate students.This paper addresses current issues in graduate course teaching,such as ambiguou...Graduate course teaching plays an irreplaceable role in knowledge mastery,skill enhancement,and quality cultivation of graduate students.This paper addresses current issues in graduate course teaching,such as ambiguous objectives,formulaic content,formalistic operation,and oversimplified evaluation.It proposes corresponding solutions with the hope of steering graduate course teaching back to its original purpose and realizing its true significance.展开更多
Objective:The objective is to explore the protective mechanisms of the Fuzheng Buxue recipe(FBR)against chemotherapy-induced myelosuppression(CIM),focusing on its potential to activate the Notch signaling pathway.Mate...Objective:The objective is to explore the protective mechanisms of the Fuzheng Buxue recipe(FBR)against chemotherapy-induced myelosuppression(CIM),focusing on its potential to activate the Notch signaling pathway.Materials and Methods:A rat model of myelosuppression was induced using 5-fluorouracil(5-FU).The rats were divided into five groups:control,CIM,batyl alcohol,low-dose FBR,and high-dose FBR(HD-FBR).After a 14-day treatment period,white blood cell(WBC)count,red blood cell count,platelet count,and hemoglobin levels in all rats were evaluated.Histopathological assessments of the thymus,spleen,and bone marrow were conducted using hematoxylin and eosin staining.In addition,expression levels of Notch1,Notch2,Jagged1,and DLL1 proteins in bone marrow tissues were measured at the protein and mRNA levels using western blotting and reverse transcription-quantitative polymerase chain reaction.Results:The CIM group exhibited significantly lower blood cell counts compared to the control group(P<0.05).The HD-FBR group showed notably normalized WBC counts,similar to the results observed in the batyl alcohol group.HD-FBR treatment also enhanced spleen mass,index,and nodule counts,approaching the levels observed in the control group(P>0.05).5-FU induced damage to immune organs and the bone marrow of rats,but HD-FBR significantly mitigated these pathological alterations.While 5-FU diminished the expression of Notch1,Notch2,Jagged1,and DLL1 proteins and mRNA(P<0.05),HD-FBR counteracted this reduction,leading to significant upregulation(P<0.05).Conclusions:FBR mitigates CIM by activating the Notch signaling pathway,highlighting its potential as a therapeutic strategy.展开更多
基金supported by the National Natural Science Foundation of China(72164018)Humanities and Social Sciences Research Planning Foundation of the Ministry of Education(22YJA190012)+1 种基金Jiangxi Universities Key Research Base Project of Humanities and Social Sciences(JD23071)Jiangxi Provincial Colleges and Universities Ideological and Political Education Research Association Project(XSGZ24239).
文摘Objectives:The aim of this study was to verify the causal relationship between trait aggressiveness(TA)and moral disengagement(MD),know more about the growth trajectory of MD,and explore the effects of gender and TA on the growth trajectory.Methods:We used the Buss-Perry Aggression Questionnaire and Moral Disengagement Scale to survey 433 Chinese junior high school students longitudinally three times.Results:The results of the random intercept cross-lagged panel model(RI-CLPM)analysis indicated that TA positively predicted MD,while MD did not predict TA at the within-person level.Thus,TA could be considered an antecedent variable of MD.Furthermore,the unconditional latent growth linear model analysis revealed that MD among junior high school students exhibited an upward trend,characterized by an increasing rate of growth over time.In the conditional latent growth linear model analysis,we found that gender influenced only the initial level of MD but had no effect on its growth rate.Conversely,TA demonstrated both delayed and immediate positive effects on the growth of MD.Conclusions:Our findings suggested a one-way cross-lag effect between TA and MD.Additionally,the growth trajectory of MD among junior high school students was found to be ascending.This growth trajectory was influenced by gender and TA,offering valuable insights for the prevention and intervention of behavioral problems in junior high school students.
基金supported by 2023 Jiangsu Province University Philosophy and Social Science Research General Project:Research on the Comprehensive Management Model of One-Stop Student Community in Universities(Grant No.2023SJSZ0084)2023 Research Topic on Party Building and Ideological and Political Education of Nanjing Tech University Category II Funding Topic:Building a Practice Education System in Universities based on Red Cultural Resources(Grant No.SZ20230220)2023 Research Topic on Party Building and Ideological and Political Education of Nanjing Tech University Category III Funding Topic:Research on Comprehensive Management Mode of One-Stop Student Community in Universities(Grant No.SZ20230316).
文摘This research was to investigate the intervention effect of art-making on the anxiety symptoms of college students. A sample of 400college students took part in this research. They were assigned to the experiment group (n = 200) and the control group (n = 200)according to Self-Rating Anxiety Scale (SAS) scores. Unlike the control group, the experiment group received a standard artmaking program under the supervision of trained instructors for a period of twelve sessions two times weekly which wascontinued for six weeks. Self-Rating Anxiety Seale (SAS) and Hamilton Anxiety Scale (HAMA) were used to assess anxietysymptoms level. Significant decreases in anxiety symptoms (p < 0.05) were found in the experiment group compared with thecontrol group. Using the art-making program to relieve anxiety, the shortest intervention period is three weeks. Art-makingcan effectively alleviate college students’ anxiety, and also can effectively improve the physical health, mental health, and socialhealth levels of college students.
基金supported by Hainan Provincial Natural Science Foundation of China(grant number 821RC1124)the Education Department of Hainan Province(grant number Hnjgzc2022-22)+1 种基金the Hainan Medical University(grant numbers XGZX2020003,HYPY2020028,and HYYB202131)Hainan Province Clinical Medical Center(QWYH202175).
文摘Objective: To identify the moderating effects of cognitive reappraisal(CR) and expressive suppression(ES) on the relationship between posttraumatic stress(PTS) symptoms and posttraumatic growth(PTG) in university students. Methods: The survey included 1 987 Chinese university students who completed questionnaires on PTS symptoms in February 2020, with three follow-up surveys at two-month intervals until August 2020. We assessed CR and ES at February 2020 and PTG at August 2020. Growth mixture modeling was used to classify the PTS symptom trajectories. Multinomial logistic regression was used to recognize the predictors of class membership. The relationships among PTS symptoms, CR, ES, and PTG were examined using multi-group path analysis.Results: Sex, SARS-Co V-2 infection of a family member or friend, number of siblings, CR, and ES were significantly associated with PTS symptoms. Three latent classes were identified: ‘Increasing PTS’(n=205, 10.0%) who had rapid deterioration of PTS symptoms, ‘Moderate PTS’(n=149, 8.0%) who had a high level of PTS symptoms at the beginning and slightly increasing, and ‘Persistent Minimal PTS’(n=1 633, 82.0%), who had slow resolution of PTS symptoms over time. Male, SARS-Co V-2 infection of a family member or friend, and having a lower CR and a higher ES, were more likely to have ‘Increasing PTS’. PTS at February 2020 predicted PTG only in ‘Increasing PTS’ class, and both CR and ES had moderating effects on the conversion between them.Conclusions: Most students recovered from posttraumatic stress of COVID-19 pandemic, but a small proportion expeienced increasing PTS symptoms, and those with this condition may benefit from emotional regulation intervention.
文摘The report of the 19th communist party of China national congress on youth work provides theoretical support and practical guidance for the realization of the ideological value of college students in the new era.In the new era,it is necessary to comprehensively and deeply study and judge the value situation of young students in colleges and universities,crack the problems and shortcomings faced by ideological and political work in colleges and universities,and explore effective educational paths in the practice of ideological and political work,so as to orderly realize the ideological value guidance of college students.
文摘Public security colleges shoulder the responsibility of cultivating and transporting qualified policemen to public security institutions. They are the cradle cultivating police. Strengthening basic construction of public security colleges and universities ,combining each aspect management and teaching work thus forming a perfect management system is the cornerstone promoting long-term development of public security education undertakings. Since 2011, Students＇ Affairs Office of Criminal Police College of China has developed and implemented basic construction programs, starting with students organizations at grassroots level, achievinv better results. It has certain reference significance for improving student management work in public security colleges.
文摘Through a case study of a college student experiencing anxiety,this paper elucidates the structured consultation process of cognitive behavioral therapy,highlighting the application,techniques,and outcomes of relevant consultation methods.The consultation aims to assist the client in overcoming challenges,improving emotional well-being,and reshaping thought patterns to achieve the desired therapeutic effects.
文摘Amidst the unique challenges faced by rural educators is their sense of decent work influenced by levels of social support,career self-efficacy,and marginalization.To investigate these relationships,we surveyed 435 rural school teachers(females=69.32%,mean years teaching experience=13.6,SD=7.7 years).The Structural Equation Modeling results indicated that social support positively predicts teachers’perceptions of decent work.Career self-efficacy mediated the relationship between social support and a higher sense of decent work,while marginalization mediated the relationship such that lower social support predicted lower perceptions of decent work.Career self-efficacy and marginalization also had a sequential mediation relationship:higher social support enhanced career self-efficacy,which in turn reduced marginalization experiences,ultimately improving teachers’perceptions of decent work.These findings align with the predictions of Social Cognitive Career Theory and the Psychology of Working Theory,demonstrating that environmental supports enhance personal psychological resources,reduce marginalization risks,and promote positive work-related outcomes.The study findings highlight the necessity for education departments to improve rural teachers’perceptions of decent work by providing social support to foster positive work experiences for teachers at high risk for marginalization and diminished career self-efficacy.
基金supported by the research grant from Hainan Medical University(No.XGZX2020003)the fund from Working Committee for Talents of Hainan Province(No.20192166)+2 种基金the Project of Basic Platform of National Science and Technology Resources of the Ministry of Sciences and Technology of China(No.TDRC-2019-194-30)Science and Technology Planning Project of Guangdong Province(No.2019B030316025)the 111 Project(No.B12003)
文摘Objective:To examine the effects of coronavirus disease-2019(COVID-19)exposure,expressive suppression/cognitive reappraisal,and demographic variables on post-traumatic stress symptoms(PTS)among Chinese.Methods:Participants were recruited by social media through We Chat and 6049 Chinese(aged from 17 to 63 years;median=24)from 31 provinces were included in the study.PTS symptoms,expressive suppression,and cognitive reappraisal were assessed after the outbreak of COVID-19.A regression mixture analysis was conducted in Mplus 7.Results:A regression mixture model identified three latent classes that were primarily distinguished by differential effects of COVID-19 exposures on PTS symptoms:(1)Class 1(mildly PTS symptoms,80.9%),(2)Class 2(moderate PTS symptoms,13.0%),and(3)Class 3(high PTS symptoms,6.1%).The results demonstrated that the young,women and people with responsibilities and concerns for others were more vulnerable to PTS symptoms;and they had more expression inhibition and less cognitive reappraisal in three latent classes.Conclusions:The findings suggest that more attention needs to be paid to vulnerable groups such as the young,women and people with responsibilities and concerns for others.Therapies to encourage emotional expression and increase cognitive reappraisal may also be helpful for trauma survivors.
文摘In the context of the era of continuous development of artificial intelligence, the labor value of university students is impacted by technological substitution. Simultaneously, university students are also required to constantly update their skills. All of the above will be the challenge of university students’ employment prospects. However, artificial intelligence will also bring new opportunities, which will stimulate the innovation ability of university students and bring new directions for employment. In order to better cope with the possible impact of artificial intelligence, universities should incorporate employment guidance services into the “three-wide education” system. To achieve this, universities need to take the following measures: developing the dynamic monitoring system of university employment based on big data, constructing the employment guidance curriculum system of university students throughout the whole process, updating the mode of diversified employment guidance service as well as establishing a team of employment guidance teachers keeping pace with the times. These measures aim to better adapt to the job market demands in the context of artificial intelligence, guide students to actively respond to the possible impact of artificial intelligence technology, cultivate their core competencies and qualities that are less likely to be replaced by artificial intelligence, and promote the high-quality employment of university students.
文摘Dispute upon the Taoist natural philosophical ethic value and the spreading and application of the ecological ethic customs in the academic circle blocks related research upon the ecological ethics of Taoist natural philosophy.With regard to the two research focuses of the ecological ethics at present—the continuous development of the modern ecological protection and the wild value strategy of ecological maintenance,it is useful to excavate the development from ecological phenomenological cognition to ecological image system so as to provide a new perspective for research upon the Taoist philosophy;at the same time,having a better understanding of the significance of treating ecology as the ethnography is good for integrating the Taoist natural philosophy into ecological theories and developing the national ethical value.
文摘Micro- injury （exercise-induced muscle damage, EIMD） will cause a temporary decline in muscle function, if not handled properly, it could cause more serious injury or overtraining, and even lead to the end of the athletes ＇ sports life. However, some studies have shown that an appropriate period of eccentric exercise training resulted in EIMD while promoted heart muscle fiber hypertrophy and corresponding muscle growth faster than exercise training, and there are the typical ＂ repetitive training effect＂ , ie after a period of the EIMD recovery, the muscle＇ s injury or delayed onset muscle soreness （DOMS） caused by the same movement is significantly reduced. So its deep study could help to guide the athlete to avoid or mitigate the negative effects which brought by EIMD, while could help to further clarify the process of the body to adapt to exercise training or mechanism.
基金Research on the Dilemma and Path of Cultivating Medical Students’Professionalism in the Perspective of Newcomers of the Times(Y202354086)。
文摘Graduate course teaching plays an irreplaceable role in knowledge mastery,skill enhancement,and quality cultivation of graduate students.This paper addresses current issues in graduate course teaching,such as ambiguous objectives,formulaic content,formalistic operation,and oversimplified evaluation.It proposes corresponding solutions with the hope of steering graduate course teaching back to its original purpose and realizing its true significance.
基金supported by the National Natural Science Foundation of China(82205237)the Matching Project for the Youth Fund of the National Natural Science Foundation of Nanjing University of Chinese Medicine(XPT82205237)the Jiangsu Provincial Department of Health Medical Science Research Project(Z2021065)。
文摘Objective:The objective is to explore the protective mechanisms of the Fuzheng Buxue recipe(FBR)against chemotherapy-induced myelosuppression(CIM),focusing on its potential to activate the Notch signaling pathway.Materials and Methods:A rat model of myelosuppression was induced using 5-fluorouracil(5-FU).The rats were divided into five groups:control,CIM,batyl alcohol,low-dose FBR,and high-dose FBR(HD-FBR).After a 14-day treatment period,white blood cell(WBC)count,red blood cell count,platelet count,and hemoglobin levels in all rats were evaluated.Histopathological assessments of the thymus,spleen,and bone marrow were conducted using hematoxylin and eosin staining.In addition,expression levels of Notch1,Notch2,Jagged1,and DLL1 proteins in bone marrow tissues were measured at the protein and mRNA levels using western blotting and reverse transcription-quantitative polymerase chain reaction.Results:The CIM group exhibited significantly lower blood cell counts compared to the control group(P<0.05).The HD-FBR group showed notably normalized WBC counts,similar to the results observed in the batyl alcohol group.HD-FBR treatment also enhanced spleen mass,index,and nodule counts,approaching the levels observed in the control group(P>0.05).5-FU induced damage to immune organs and the bone marrow of rats,but HD-FBR significantly mitigated these pathological alterations.While 5-FU diminished the expression of Notch1,Notch2,Jagged1,and DLL1 proteins and mRNA(P<0.05),HD-FBR counteracted this reduction,leading to significant upregulation(P<0.05).Conclusions:FBR mitigates CIM by activating the Notch signaling pathway,highlighting its potential as a therapeutic strategy.
