Dear Editor,Of all human tumors,pheochromocytomas and paragangliomas(PPGLs)have the highest heritability rate.Over 15%of PPGLs harbor mutations in genes encoding tricarboxylic acid(TCA)cycle-related enzymes that cause...Dear Editor,Of all human tumors,pheochromocytomas and paragangliomas(PPGLs)have the highest heritability rate.Over 15%of PPGLs harbor mutations in genes encoding tricarboxylic acid(TCA)cycle-related enzymes that cause oncometabolite accumulation and drive tumorigenesis via metabolic adaptation to hypoxia and global hypermethylation[1].The dihydrolipoamide S-succinyltransferase(DLST)gene was recently described as a new PPGL susceptibility gene[2].展开更多
基金supported by the Instituto de Salud CarlosⅢ(ISCⅢ)through the“Acción Estratégica en Salud”(AES)(projects PI18/00454 and PI22/01490 to A.C.and PI20/01169 to M.R.)cofounded by the European Regional Development Fund(ERDF)+1 种基金supported by the Spanish Ministry of Science,Innovation and Universities“Formación del Profesorado Universitario-FPU”fellowship with ID number FPU19/04940supported by‘la Caixa’Foundation(ID 100010434)under agreement LCF/BQ/PI20/11760011.
文摘Dear Editor,Of all human tumors,pheochromocytomas and paragangliomas(PPGLs)have the highest heritability rate.Over 15%of PPGLs harbor mutations in genes encoding tricarboxylic acid(TCA)cycle-related enzymes that cause oncometabolite accumulation and drive tumorigenesis via metabolic adaptation to hypoxia and global hypermethylation[1].The dihydrolipoamide S-succinyltransferase(DLST)gene was recently described as a new PPGL susceptibility gene[2].
