Objective To investigate the serum total IgE （tlgE） and specific IgE （slgE） to common allergens among allergic patients in Guangzhou, China. Methods 7 085 patients were examined for tlgE and slgE to 15 allergens, ...Objective To investigate the serum total IgE （tlgE） and specific IgE （slgE） to common allergens among allergic patients in Guangzhou, China. Methods 7 085 patients were examined for tlgE and slgE to 15 allergens, based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay. Results 3 758 （53.04%） patients tested positive for tlgE, and 4 640 （65.49%） for slgE. Der pteronyssinus, Derfarinae, eggs, and cow＇s milk were the most common allergens leading to higher positive rates of slgE responses. Several peaks of sensitization were： Der pteronyssinus, Derfarinae, and Blomia tropicalis at age 10-12; cow＇s milk at age below 3; eggs at age 4-6. The mean level and positive rate of tlgE tended to increase in subjects sensitized to more allergens. Sensitization to Der pteronyssinus （OR, 1.6; P〈O.05）, Der farinae （OR, 1.5; P〈O.05）, Blomia tropicalis （OR, 1.4; P〈O.05）, Blattella germanica （OR, 1.5; P〈O.05）, cow＇s milk （OR, 1.3; P〈O.05）, and soy beans （OR, 2.0; P〈O.05） were independently correlated with allergy-related conditions in preliminary diagnosis. Conclusion The major allergens in Guangzhou include Derpteronyssinus, Derfarinae, cow＇s milk, and eggs. Sensitization to these allergens appears to be predictors of allergy-related disorder.展开更多
In recent years,the usage,management and benefit of large-scale scientific research instruments and equipment in scientific research institutes have been a leading issue in the management of scientific research instit...In recent years,the usage,management and benefit of large-scale scientific research instruments and equipment in scientific research institutes have been a leading issue in the management of scientific research institutes.Within the scope of equipment budget,it is necessary for each equipment acquisition team to conduct a round of communication,coordination and negotiation with suppliers in order to improve the cost performance of equipment procurement and maximize the performance index to meet the needs of scientific research.By introducing the practical experience of the State Key Laboratory in purchasing imported equipment and managing large-scale instruments,this paper probes into the management process of the imported large-scale scientific research tax-free equipment of scientific research institutes,and explores the system and methods to guarantee and improve the efficiency of large-scale instruments in scientific research institutes from the aspects of policy,funds and technology.展开更多
The State Key Laboratory of Natural and Biomimetic Drugs was approved for a funding of nearly 100 million yuan specifically aimed at the purchase and maintenance of equipment and instruments from 2018 to 2020,which is...The State Key Laboratory of Natural and Biomimetic Drugs was approved for a funding of nearly 100 million yuan specifically aimed at the purchase and maintenance of equipment and instruments from 2018 to 2020,which is a record high.The Laboratory focuses on two major directions of scientific research,the"basic scientific problems of drug resistance of complex components of natural products"and the"key biomimetic scientific problems of endogenous substances therapeutic functions".The selection of scientific instruments and equipment,trial production,upgrading,as well as high level of technical and management personnel allocation and other aspects are critical to meet the development needs of the Key Laboratory and to maintain the advantages and leading role in these two major directions of scientific research.展开更多
This year marks the tenth anniversary of the State Key Laboratory of Advanced Displays and Optoelectronics Technologies(SKLADOT)at the Hong Kong University of Science and Technology(HKUST).The predecessor of SKLADOT w...This year marks the tenth anniversary of the State Key Laboratory of Advanced Displays and Optoelectronics Technologies(SKLADOT)at the Hong Kong University of Science and Technology(HKUST).The predecessor of SKLADOT was the Center for Display Research(CDR)which was started in 1995.Thus display research has a long history at HKUST.展开更多
·Prof.XIONG,could you please give us a brief introduction to SKLMCMS？Director XIONG Ke：The State Key Laboratory of Mechanics and Control of Mechanical Structures（SKLMCMS）was established with the approval of t...·Prof.XIONG,could you please give us a brief introduction to SKLMCMS？Director XIONG Ke：The State Key Laboratory of Mechanics and Control of Mechanical Structures（SKLMCMS）was established with the approval of the Ministry of Science and Technology of the People’s Republic of China in October 2011.The laboratory is located at Nanjing University of Aeronautics and Astronautics（NUAA）.展开更多
The power system is experiencing a higher penetration of renewable energy generations(REGs).The short circuit ratio(SCR)and the grid impedance ratio(GIR)are two indices to quantify the system strength of the power sys...The power system is experiencing a higher penetration of renewable energy generations(REGs).The short circuit ratio(SCR)and the grid impedance ratio(GIR)are two indices to quantify the system strength of the power system with REGs.In this paper,the critical short circuit ratio(CSCR)is defined as the corresponding SCR when the system voltage is in the critical stable state.Through static voltage stability analysis,the mathematical expression of the CSCR considering the impact of GIR is derived.The maximum value of CSCR is adopted as the critical value to distinguish the weak power system.Based on the static equivalent circuit analysis,it is proved that the CSCR is still effective to evaluate critical system strength considering the interactive impact among REGs.Finally,we find that the GIR can be neglected and the SCR can be used individually to evaluate the system strength when SCR>2 or GIR>5.The correctness and rationality of the CSCR and its critical value are validated on ADPSS.展开更多
Phase-matching quantum-key distribution(PM-QKD)has achieved significant results in various practical applications.However,real-time communication requires dynamic adjustment and optimization of key parameters during c...Phase-matching quantum-key distribution(PM-QKD)has achieved significant results in various practical applications.However,real-time communication requires dynamic adjustment and optimization of key parameters during communication.In this letter,we predict the PM-QKD parameters using nature-inspired algorithms(NIAs).The results are obtained from an exhaustive traversal algorithm(ETA),which serves as a benchmark.We mainly study the parameter optimization effects of the two NIAs:ant colony optimization(ACO)and the genetic algorithm(GA).The configuration of the inherent parameters of these algorithms in the decoy-state PM-QKD is also discussed.The simulation results indicate that the parameters obtained by the ACO exhibit superior convergence and stability,whereas the GA results are relatively scattered.Nevertheless,more than 97%of the key rates predicted by both algorithms are highly consistent with the optimal key rate.Moreover,the relative error of the key rates remained below 10%.Furthermore,NIAs maintain power consumption below 8 W and require three orders of magnitude less computing time than ETA.展开更多
EngineeringAsking good questions is often a starting point of a revolutionary breakthrough.Good examples include the famous 7 Clay millennium problems and the 125 open questions released in SCIENCE in 2021 at the 125t...EngineeringAsking good questions is often a starting point of a revolutionary breakthrough.Good examples include the famous 7 Clay millennium problems and the 125 open questions released in SCIENCE in 2021 at the 125th anniversary of Shanghai Jiaotong University(SJTU),which greatly promote the development in mathematics,science and technology.展开更多
Fiber materials are essential to national economic growth,people’s livelihoods,and social progress.They have been widely used in clothing,aerospace,energy devices,flexible electronics,tissue engineering,and many othe...Fiber materials are essential to national economic growth,people’s livelihoods,and social progress.They have been widely used in clothing,aerospace,energy devices,flexible electronics,tissue engineering,and many other fields.The chemical fiber industry of China was underdeveloped before the early 1980s,and even could not produce enough chemical fiber products for clothing.展开更多
1.Introduction.Since the Industrial Revolution,the partial pressure of atmospheric carbon dioxide(pCO_(2))has increased markedly,rising from approximately 280 ppm(1 ppm=1μL/L)to about 420 ppm.This escalation has inte...1.Introduction.Since the Industrial Revolution,the partial pressure of atmospheric carbon dioxide(pCO_(2))has increased markedly,rising from approximately 280 ppm(1 ppm=1μL/L)to about 420 ppm.This escalation has intensified global warming,with 2024 the hottest year on record since 1850.The global mean temperature now stands 1.46℃ above the pre-industrial average(1850-1900),a value already approaching the 1.5℃ threshold set by the Paris Agreement(NOAA,2025).展开更多
Clay minerals play a crucial role in catalyzing kerogen to form hydrocarbons,significantly influencing petroleum system evolution.Montmorillonite(MT)dehydrates upon heating;however,the catalytic mechanisms governing t...Clay minerals play a crucial role in catalyzing kerogen to form hydrocarbons,significantly influencing petroleum system evolution.Montmorillonite(MT)dehydrates upon heating;however,the catalytic mechanisms governing the thermal decomposition of organic matter at different dehydration levels remain unclear.Additionally,the mechanism by which external water suppresses MT’s catalytic efficiency remains debated.To resolve this issue,this study conducted pyrolysis simulation experiments(340℃,10 days)with various combinations of octadecanoic acid(OA),water,hydrochloric acid(HCl)solution,MT,dehydrated-MT,and illite.We integrated mineral/organic transformation analyses(XRD/FTIR/SSNMR/SEM),temperature-dependent characterization of solid acid sites(NH 3-TPD/FTIR),and quantitative product measurements(GC/GC-MS)to elucidate how clay-bound water and external water differentially regulate organic-matter cracking pathways.The results suggest that clay-bound water controls reaction pathways by tuning both the type(Brønsted vs.Lewis)and density of solid acid sites.External water inhibits catalytic efficiency by reducing direct contact between organic matter and solid acid sites.Compared with untreated MT,150°C-dehydrated MT-OA system exhibited strong interlayer water polarization,which increased Brønsted acid site density and enhanced the carbonium-ion mechanism,thereby promoting isoalkane production.In contrast,250℃-dehydrated MT-OA system,where interlayer water was nearly eliminated,had fewer Brønsted acid sites but greater exposure of Lewis acid sites,facilitating decarboxylation and increasing CO_(2) production.In hydrous systems,the addition of HCl solution did not enhance the carbonium-ion mechanism compared to the hydrous system with only water,indicating that only protons bound to solid acid sites,rather than liquid H+in water,can trigger the carbonium-ion reaction.This shows that the catalysis of organic-matter cracking by clay minerals such as MT is fundamentally an interfacial chemical process that requires direct mineral-organic contact;the presence of external water reduces catalytic efficiency primarily by physically separating OA from MT and hindering that contact.This study elucidates the controlling mechanisms of MT-catalyzed thermal cracking under different water conditions and deepens our understanding of hydrocarbon-generation pathways during kerogen maturation in sedimentary basins.展开更多
High-nickel cathode,LiNi0.8Co0.1Mn0.1O_(2)(NCM811),and sulfide-solid electrolyte are a promising combination for all-solid-state lithium batteries(ASSLBs).However,this combination faces the issue of interfacial instab...High-nickel cathode,LiNi0.8Co0.1Mn0.1O_(2)(NCM811),and sulfide-solid electrolyte are a promising combination for all-solid-state lithium batteries(ASSLBs).However,this combination faces the issue of interfacial instability between the cathode and electrolyte.Given the surface alkalinity of NCM811,we propose a strategy to construct a solid-polymer-electrolyte(SPE)interphase on NCM811 surface by leveraging the surface alkaline residues to nucleophilically initiate the in-situ ring-opening polymerization of cyclic organic molecules.As a proof-of-concept,this study demonstrates that the ring-opening copolymerization of 1,3-dioxolane and maleic anhydride produces a homogeneous,compact,and conformal SPE layer on NCM811 surface to prevent the cathode from contact and reaction with Li6PS5Cl solid-state electrolyte.Consequently,the SPE-modified-NCM811 in ASSLBs exhibits high capacities of 193.5 mA h g^(-1) at 0.2 C,160.9 mA h g^(-1) at 2.0 C and 112.3 mA h g^(-1) at 10 C,and particularly,excellent long-term cycling stabilities over 11000 cycles with a 71.95%capacity retention at 10 C at 25℃,as well as a remained capacity of 117.9 mA h g^(-1) after 8000 cycles at 30 C at 60℃,showing a great application prospect.This study provides a new route for creating electrochemically and structurally stable solid-solid interfaces for ASSLBs.展开更多
The octupole correlations of the K^(π)=5/2^(+)ground state and the rotational spectrum built on it in^(229)Th are studied using the microscopic relativistic density functional theory on a three-dimensional lattice sp...The octupole correlations of the K^(π)=5/2^(+)ground state and the rotational spectrum built on it in^(229)Th are studied using the microscopic relativistic density functional theory on a three-dimensional lattice space and the reflection-asymmetric triaxial particle rotor model.It is found that^(229)Th has a ground state with static axial octupole and quadrupole deformations.The occurrence of octupole correlations,driven by the octupole deformation,is analyzed through the evolution of single-particle levels around the Fermi surface.The experimental energy spectrum and the electromagnetic transition probabilities,including B(E2)and B(M1),are reasonably well reproduced.展开更多
Penthorum chinense Pursh has been used for centuries as an herbal medicine and food in East Asia.The main active substances in P.chinense are galloylated macrocyclic polyphenolic compounds,which have excellent medicin...Penthorum chinense Pursh has been used for centuries as an herbal medicine and food in East Asia.The main active substances in P.chinense are galloylated macrocyclic polyphenolic compounds,which have excellent medicinal properties.Galloylation and glycosylation are key steps in the formation of polyphenolic compounds,as the glycosylation of flavonoids is required for the acylation of flavonoid glycosides,and the glycosylation of gallic acid is necessary for its role as an acyl donor.Therefore,glycosylation to generate the acyl donor or acceptor is a core step in the biosynthesis of polyphenolic compounds.However,how this glycosylation occurs in P.chinense is unknown.In this study,we determined that the UDP-glucose transferase PcUGT84A82 mediates the glycosylation of gallic acid and pinocembrin to produce 1-O-Galloyl-β-D-glucose and pinocembroside,respectively.Metabolic profiling of polyphenolic compounds using UHPLC-ESI–Q-TOF/MS revealed high levels of polyphenols in flowers,leaves,and roots,and low levels in stems of P.chinense.We performed isoform-sequencing(Iso-seq)to assemble a full-length transcriptome of P.chinense,from which we identified 58 UGT family members.PcUGT84A82 is highly similar to functional UGTs in other plant species,and PcUGT84A82 transcript levels were positively correlated with the levels of various polyphenolic compounds.We validated the function of PcUGT84A82 via in vitro enzyme assays and transient expression in Nicotiana benthamiana leaves.Subcellular localization tests showed that PcUGT84A82 localizes to the nucleus and cytoplasm.In summary,PcUGT84A82 catalyzes the conversion of gallic acid to 1-O-Galloyl-β-D-glucose as the acyl donor and pinocembrin to pinocembroside as the acyl acceptor,mediating the biosynthesis of galloylated macrocyclic polyphenolic compounds in P.chinense.These findings lay the foundation for elucidating the entire biosynthetic pathway of active polyphenols in this important herbal plant species.展开更多
While injection-induced seismicity has been widely studied,its implications for CO_(2)geological storage require reevaluation due to distinct fluid-rock interactions.This study develops a coupled hydromechanical model...While injection-induced seismicity has been widely studied,its implications for CO_(2)geological storage require reevaluation due to distinct fluid-rock interactions.This study develops a coupled hydromechanical model incorporating rate-and-state friction laws to investigate fault reactivation mechanisms during early-stage CO_(2)injection.The competing effects of pore pressure diffusion and fluid pressurization are systematically investigated,considering three key factors:permeability variations within fault damage zones,normal stress variation coefficients,and injection parameters.Numerical simulations reveal that slower CO_(2)migration causes limited pressure perturbation(<0.3 MPa over 15 d)compared to single-phase fluid injection.Fluid pressurization enhances fault strength and delays reactivation,though this stabilizing effect diminishes in low-permeability damage zones.Highly permeable damage zones promote larger rupture areas despite strengthening from pressurization,as reduced effective stress accelerates failure.Paradoxically,while fluid pressurization increases fault strength,it simultaneously elevates seismic risk through amplified stress drops during slip events.Temporal analysis shows that fluid pressurization dominates initial fault response,while sustained pore pressure diffusion ultimately drives reactivation.Increased normal stress variation coefficients and injection rates accelerate localized rupture initiation but restrict propagation due to non-critically stressed states.This discrepancy demonstrates that regions with positive Coulomb failure stress changes do not correlate well with actual slip zones.These findings highlight the critical interplay between transient pressurization effects and progressive pressure diffusion during early CO_(2)injection phases,providing crucial insights for seismic risk management in CO_(2)storage projects.展开更多
Metal hydrides with high hydrogen density provide promising hydrogen storage paths for hydrogen transportation.However,the requirement of highly pure H_(2)for re-hydrogenation limits its wide application.Here,amorphou...Metal hydrides with high hydrogen density provide promising hydrogen storage paths for hydrogen transportation.However,the requirement of highly pure H_(2)for re-hydrogenation limits its wide application.Here,amorphous Al_(2)O_(3)shells(10 nm)were deposited on the surface of highly active hydrogen storage material particles(MgH_(2)-ZrTi)by atomic layer deposition to obtain MgH_(2)-ZrTi@Al_(2)O_(3),which have been demonstrated to be air stable with selective adsorption of H_(2)under a hydrogen atmosphere with different impurities(CH_(4),O_(2),N_(2),and CO_(2)).About 4.79 wt% H_(2)was adsorbed by MgH_(2)-ZrTi@10nmAl_(2)O_(3)at 75℃under 10%CH_(4)+90%H_(2)atmosphere within 3 h with no kinetic or density decay after 5 cycles(~100%capacity retention).Furthermore,about 4 wt%of H_(2)was absorbed by MgH_(2)-ZrTi@10nmAl_(2)O_(3)under 0.1%O_(2)+0.4%N_(2)+99.5%H_(2)and 0.1%CO_(2)+0.4%N_(2)+99.5%H_(2)atmospheres at 100℃within 0.5 h,respectively,demonstrating the selective hydrogen absorption of MgH_(2)-ZrTi@10nmAl_(2)O_(3)in both oxygen-containing and carbon dioxide-containing atmospheres hydrogen atmosphere.The absorption and desorption curves of MgH_(2)-ZrTi@10nmAl_(2)O_(3)with and without absorption in pure hydrogen and then in 21%O_(2)+79%N_(2)for 1 h were found to overlap,further confirming the successful shielding effect of Al_(2)O_(3)shells against O_(2)and N_(2).The MgH_(2)-ZrTi@10nmAl_(2)O_(3)has been demonstrated to be air stable and have excellent selective hydrogen absorption performance under the atmosphere with CH_(4),O_(2),N_(2),and CO_(2).展开更多
When two layers of graphene are stacked with a twist angle of approximately 1.1°,strong interlayer coupling gives rise to a pair of flat bands in twisted bilayer graphene(TBG),resulting in pronounced electron–el...When two layers of graphene are stacked with a twist angle of approximately 1.1°,strong interlayer coupling gives rise to a pair of flat bands in twisted bilayer graphene(TBG),resulting in pronounced electron–electron interactions.At half filling of the flat bands,TBG exhibits correlated insulating states.Here,we investigate the electrical transport properties of heterostructures composed of TBG and the antiferromagnetic insulator chromium oxychloride(CrOCl),and propose a strategy to modulate the correlated insulating states in TBG.During the transition from a conventional phase to a strong interfacial coupling phase,kink-like features are observed in the charge neutrality point(CNP),correlated insulating state,and band insulating state.Under a perpendicular magnetic field,the system exhibits broadened quantum Hall plateaus in the strong interfacial coupling regime.Electrons localized in the CrOCl layer screen the bottom gate,rendering the carrier density in TBG less sensitive to variations in the bottom gate voltage.These phenomena are well captured by a charge-transfer model between TBG and CrOCl.Our results provide insights into the control of electronic correlations and topological states in graphene moirésystems via interfacial charge coupling.展开更多
Keystone taxa are critical for microbial community homeostasis and ecological niche interactions.However,the functions and genomic traits of endophytic keystone fungi in plant tissues remain unclear.Via network analys...Keystone taxa are critical for microbial community homeostasis and ecological niche interactions.However,the functions and genomic traits of endophytic keystone fungi in plant tissues remain unclear.Via network analysis,this study identified keystone fungi Plectosphaerella(Plec)and Cladosporium(Clad)in roots/leaves of medicinal Panax plants(P.ginseng,P.quinquefolius,P.notoginseng).Both correlated strongly positively with ginsenoside Rd content in respective tissues(ρ>0.6,p<0.001).Co-cultivation confirmed their ability to convert ginsenoside Rb1 to Rd,linked toβ-glucosidase activity.Whole-genome sequencing/assembly/evolutionary analysis of the two strains elucidated genomic features for their keystone roles and saponin biotransformation.Genome mining found multiple GH3 genes(potential saponin transformers)in both;11(Plec)and 5(Clad)were upregulated by cellobiose.Gene family phylogenetic analysis showed expanded transmembrane transport and environmental response functions.Both also had abundant secondary metabolic gene clusters and secretome genes,linking biotic interaction functions to their keystone roles.In summary,this study shows Panax endophytic keystone fungi can participate in ginsenoside biotransformation and clarifies their genomic traits,offering insights for functional endophytic fungal resource development.展开更多
The hybridization gap in strained-layer InAs/In_(x)Ga_(1−x) Sb quantum spin Hall insulators(QSHIs)is significantly enhanced compared to binary InAs/GaSb QSHI structures,where the typical indium composition,x,ranges be...The hybridization gap in strained-layer InAs/In_(x)Ga_(1−x) Sb quantum spin Hall insulators(QSHIs)is significantly enhanced compared to binary InAs/GaSb QSHI structures,where the typical indium composition,x,ranges between 0.2 and 0.4.This enhancement prompts a critical question:to what extent can quantum wells(QWs)be strained while still preserving the fundamental QSHI phase?In this study,we demonstrate the controlled molecular beam epitaxial growth of highly strained-layer QWs with an indium composition of x=0.5.These structures possess a substantial compressive strain within the In_(0.5)Ga_(0.5)Sb QW.Detailed crystal structure analyses confirm the exceptional quality of the resulting epitaxial films,indicating coherent lattice structures and the absence of visible dislocations.Transport measurements further reveal that the QSHI phase in InAs/In_(0.5)Ga_(0.5)Sb QWs is robust and protected by time-reversal symmetry.Notably,the edge states in these systems exhibit giant magnetoresistance when subjected to a modest perpendicular magnetic field.This behavior is in agreement with the𝑍2 topological property predicted by the Bernevig–Hughes–Zhang model,confirming the preservation of topologically protected edge transport in the presence of enhanced bulk strain.展开更多
Electrocatalytic glucose oxidation to high-value chemicals provides a sustainable route for biomass valorization.NiCo-based catalysts have emerged as promising candidates for glucose oxidation reaction owing to the in...Electrocatalytic glucose oxidation to high-value chemicals provides a sustainable route for biomass valorization.NiCo-based catalysts have emerged as promising candidates for glucose oxidation reaction owing to the intrinsic activity of Ni and Co catalytic centers.However,the dynamic evolution and atomic-scale synergy between these centers remain elusive.Herein,we fabricated NiCo_(2)O_(4)nanosheets supported on nickel foam,where Ni preferentially occupies tetrahedral sites to regulate the electronic configuration of octahedral Co.Experimental and theoretical results demonstrate that the incorporation of tetrahedral Ni induces low-to-intermediate spin transition in octahedral Co,thereby optimizing eg orbital occupancy and stabilizing active sites.This spin-state engineering establishes Ni-Co synergistic catalytic centers for the selective oxidation of glucose to formate(FA).At higher potential(≥1.4 V vs.RHE),octahedral Co undergoes reconstruction into excessive active CoOOH and CoO_(2)species,resulting in glucose overoxidation to CO_(2)and intensified competitive oxygen evolution.In contrast,at lower potentials(<1.4 V vs.RHE),tetrahedral Ni facilitates electron delocalization across the Ni–O–Co lattice,thereby stabilizing octahedral Co for glucose adsorption and oxidation.Subsequently,a coupled electrocatalytic system was constructed,achieving 80.7%FA yield with 91.3%Faradaic efficiency(FE)at NiCo_(2)O_(4)anode and H2 evolution rate of 696μmol h^(−1)with 99.9%FE at Pt cathode for 2 h under 1.35 V vs.RHE.This work provides a deep insight into spin-state regulation of the catalytic center,offering valuable guidance for rational catalyst design.展开更多
基金supported by Guangdong Industry Technology and Development Fund(No.2011B061200040)Science Foundation of Guangzhou Medical Univesity(Project No.2013A06)Guangdong Natural Science Foundation(No.S2013010014728)
文摘Objective To investigate the serum total IgE （tlgE） and specific IgE （slgE） to common allergens among allergic patients in Guangzhou, China. Methods 7 085 patients were examined for tlgE and slgE to 15 allergens, based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay. Results 3 758 （53.04%） patients tested positive for tlgE, and 4 640 （65.49%） for slgE. Der pteronyssinus, Derfarinae, eggs, and cow＇s milk were the most common allergens leading to higher positive rates of slgE responses. Several peaks of sensitization were： Der pteronyssinus, Derfarinae, and Blomia tropicalis at age 10-12; cow＇s milk at age below 3; eggs at age 4-6. The mean level and positive rate of tlgE tended to increase in subjects sensitized to more allergens. Sensitization to Der pteronyssinus （OR, 1.6; P〈O.05）, Der farinae （OR, 1.5; P〈O.05）, Blomia tropicalis （OR, 1.4; P〈O.05）, Blattella germanica （OR, 1.5; P〈O.05）, cow＇s milk （OR, 1.3; P〈O.05）, and soy beans （OR, 2.0; P〈O.05） were independently correlated with allergy-related conditions in preliminary diagnosis. Conclusion The major allergens in Guangzhou include Derpteronyssinus, Derfarinae, cow＇s milk, and eggs. Sensitization to these allergens appears to be predictors of allergy-related disorder.
文摘In recent years,the usage,management and benefit of large-scale scientific research instruments and equipment in scientific research institutes have been a leading issue in the management of scientific research institutes.Within the scope of equipment budget,it is necessary for each equipment acquisition team to conduct a round of communication,coordination and negotiation with suppliers in order to improve the cost performance of equipment procurement and maximize the performance index to meet the needs of scientific research.By introducing the practical experience of the State Key Laboratory in purchasing imported equipment and managing large-scale instruments,this paper probes into the management process of the imported large-scale scientific research tax-free equipment of scientific research institutes,and explores the system and methods to guarantee and improve the efficiency of large-scale instruments in scientific research institutes from the aspects of policy,funds and technology.
文摘The State Key Laboratory of Natural and Biomimetic Drugs was approved for a funding of nearly 100 million yuan specifically aimed at the purchase and maintenance of equipment and instruments from 2018 to 2020,which is a record high.The Laboratory focuses on two major directions of scientific research,the"basic scientific problems of drug resistance of complex components of natural products"and the"key biomimetic scientific problems of endogenous substances therapeutic functions".The selection of scientific instruments and equipment,trial production,upgrading,as well as high level of technical and management personnel allocation and other aspects are critical to meet the development needs of the Key Laboratory and to maintain the advantages and leading role in these two major directions of scientific research.
文摘This year marks the tenth anniversary of the State Key Laboratory of Advanced Displays and Optoelectronics Technologies(SKLADOT)at the Hong Kong University of Science and Technology(HKUST).The predecessor of SKLADOT was the Center for Display Research(CDR)which was started in 1995.Thus display research has a long history at HKUST.
文摘·Prof.XIONG,could you please give us a brief introduction to SKLMCMS？Director XIONG Ke：The State Key Laboratory of Mechanics and Control of Mechanical Structures（SKLMCMS）was established with the approval of the Ministry of Science and Technology of the People’s Republic of China in October 2011.The laboratory is located at Nanjing University of Aeronautics and Astronautics（NUAA）.
基金supported by the Science and Technology Project of State Grid Corporation of China(No.XT71-20-014).
文摘The power system is experiencing a higher penetration of renewable energy generations(REGs).The short circuit ratio(SCR)and the grid impedance ratio(GIR)are two indices to quantify the system strength of the power system with REGs.In this paper,the critical short circuit ratio(CSCR)is defined as the corresponding SCR when the system voltage is in the critical stable state.Through static voltage stability analysis,the mathematical expression of the CSCR considering the impact of GIR is derived.The maximum value of CSCR is adopted as the critical value to distinguish the weak power system.Based on the static equivalent circuit analysis,it is proved that the CSCR is still effective to evaluate critical system strength considering the interactive impact among REGs.Finally,we find that the GIR can be neglected and the SCR can be used individually to evaluate the system strength when SCR>2 or GIR>5.The correctness and rationality of the CSCR and its critical value are validated on ADPSS.
基金supported by the State Key Laboratory of Information Photonics and Optical Communications(Beijing University of Posts and Telecommunications)No.IPOC2021ZT10BUPT Excellent Ph.D.Students Foundation(Grant No.CX2023207)the BUPT innovation and entrepreneurship support program No.2024-YC-A188。
文摘Phase-matching quantum-key distribution(PM-QKD)has achieved significant results in various practical applications.However,real-time communication requires dynamic adjustment and optimization of key parameters during communication.In this letter,we predict the PM-QKD parameters using nature-inspired algorithms(NIAs).The results are obtained from an exhaustive traversal algorithm(ETA),which serves as a benchmark.We mainly study the parameter optimization effects of the two NIAs:ant colony optimization(ACO)and the genetic algorithm(GA).The configuration of the inherent parameters of these algorithms in the decoy-state PM-QKD is also discussed.The simulation results indicate that the parameters obtained by the ACO exhibit superior convergence and stability,whereas the GA results are relatively scattered.Nevertheless,more than 97%of the key rates predicted by both algorithms are highly consistent with the optimal key rate.Moreover,the relative error of the key rates remained below 10%.Furthermore,NIAs maintain power consumption below 8 W and require three orders of magnitude less computing time than ETA.
文摘EngineeringAsking good questions is often a starting point of a revolutionary breakthrough.Good examples include the famous 7 Clay millennium problems and the 125 open questions released in SCIENCE in 2021 at the 125th anniversary of Shanghai Jiaotong University(SJTU),which greatly promote the development in mathematics,science and technology.
文摘Fiber materials are essential to national economic growth,people’s livelihoods,and social progress.They have been widely used in clothing,aerospace,energy devices,flexible electronics,tissue engineering,and many other fields.The chemical fiber industry of China was underdeveloped before the early 1980s,and even could not produce enough chemical fiber products for clothing.
基金supported by the National Natural Science Foundation of China(Grant Nos.42425305,42293290,and 42172216).
文摘1.Introduction.Since the Industrial Revolution,the partial pressure of atmospheric carbon dioxide(pCO_(2))has increased markedly,rising from approximately 280 ppm(1 ppm=1μL/L)to about 420 ppm.This escalation has intensified global warming,with 2024 the hottest year on record since 1850.The global mean temperature now stands 1.46℃ above the pre-industrial average(1850-1900),a value already approaching the 1.5℃ threshold set by the Paris Agreement(NOAA,2025).
基金supported by the National Natural Science Foundation of China(Grant Nos.42488101 and 42222208)the Key R&D Program of Shandong Province,China(Grant No.2024CXPT076)the Deep Earth National Science and Technology Major Project(Grant No.2024ZD1001002).
文摘Clay minerals play a crucial role in catalyzing kerogen to form hydrocarbons,significantly influencing petroleum system evolution.Montmorillonite(MT)dehydrates upon heating;however,the catalytic mechanisms governing the thermal decomposition of organic matter at different dehydration levels remain unclear.Additionally,the mechanism by which external water suppresses MT’s catalytic efficiency remains debated.To resolve this issue,this study conducted pyrolysis simulation experiments(340℃,10 days)with various combinations of octadecanoic acid(OA),water,hydrochloric acid(HCl)solution,MT,dehydrated-MT,and illite.We integrated mineral/organic transformation analyses(XRD/FTIR/SSNMR/SEM),temperature-dependent characterization of solid acid sites(NH 3-TPD/FTIR),and quantitative product measurements(GC/GC-MS)to elucidate how clay-bound water and external water differentially regulate organic-matter cracking pathways.The results suggest that clay-bound water controls reaction pathways by tuning both the type(Brønsted vs.Lewis)and density of solid acid sites.External water inhibits catalytic efficiency by reducing direct contact between organic matter and solid acid sites.Compared with untreated MT,150°C-dehydrated MT-OA system exhibited strong interlayer water polarization,which increased Brønsted acid site density and enhanced the carbonium-ion mechanism,thereby promoting isoalkane production.In contrast,250℃-dehydrated MT-OA system,where interlayer water was nearly eliminated,had fewer Brønsted acid sites but greater exposure of Lewis acid sites,facilitating decarboxylation and increasing CO_(2) production.In hydrous systems,the addition of HCl solution did not enhance the carbonium-ion mechanism compared to the hydrous system with only water,indicating that only protons bound to solid acid sites,rather than liquid H+in water,can trigger the carbonium-ion reaction.This shows that the catalysis of organic-matter cracking by clay minerals such as MT is fundamentally an interfacial chemical process that requires direct mineral-organic contact;the presence of external water reduces catalytic efficiency primarily by physically separating OA from MT and hindering that contact.This study elucidates the controlling mechanisms of MT-catalyzed thermal cracking under different water conditions and deepens our understanding of hydrocarbon-generation pathways during kerogen maturation in sedimentary basins.
基金supported by the National Key R&D Program of China(2021YFB3800300).
文摘High-nickel cathode,LiNi0.8Co0.1Mn0.1O_(2)(NCM811),and sulfide-solid electrolyte are a promising combination for all-solid-state lithium batteries(ASSLBs).However,this combination faces the issue of interfacial instability between the cathode and electrolyte.Given the surface alkalinity of NCM811,we propose a strategy to construct a solid-polymer-electrolyte(SPE)interphase on NCM811 surface by leveraging the surface alkaline residues to nucleophilically initiate the in-situ ring-opening polymerization of cyclic organic molecules.As a proof-of-concept,this study demonstrates that the ring-opening copolymerization of 1,3-dioxolane and maleic anhydride produces a homogeneous,compact,and conformal SPE layer on NCM811 surface to prevent the cathode from contact and reaction with Li6PS5Cl solid-state electrolyte.Consequently,the SPE-modified-NCM811 in ASSLBs exhibits high capacities of 193.5 mA h g^(-1) at 0.2 C,160.9 mA h g^(-1) at 2.0 C and 112.3 mA h g^(-1) at 10 C,and particularly,excellent long-term cycling stabilities over 11000 cycles with a 71.95%capacity retention at 10 C at 25℃,as well as a remained capacity of 117.9 mA h g^(-1) after 8000 cycles at 30 C at 60℃,showing a great application prospect.This study provides a new route for creating electrochemically and structurally stable solid-solid interfaces for ASSLBs.
基金supported by the National Natural Science Foundation of China(Grant Nos.12205097,12141501,12475117,and 12435006)the National Key Laboratory of Neutron Science and Technology(Grant No.NST202401016)+1 种基金the National Key R&D Program of China(Grant Nos.2024YFA1612600 and 2024YFE0109803)the High-performance Computing Platform of Peking University。
文摘The octupole correlations of the K^(π)=5/2^(+)ground state and the rotational spectrum built on it in^(229)Th are studied using the microscopic relativistic density functional theory on a three-dimensional lattice space and the reflection-asymmetric triaxial particle rotor model.It is found that^(229)Th has a ground state with static axial octupole and quadrupole deformations.The occurrence of octupole correlations,driven by the octupole deformation,is analyzed through the evolution of single-particle levels around the Fermi surface.The experimental energy spectrum and the electromagnetic transition probabilities,including B(E2)and B(M1),are reasonably well reproduced.
基金the National Natural Science Foundation of China(82304659)a Chenguang Project of Shanghai(23CGA52)+2 种基金the Shanghai Municipal Science and Technology Commission 2025 Key Technology R&D Program“Synthetic Biology”Project(25HC2810300)the Key Project at Central Government Level:the Ability Establishment of Sustainable Use for Valuable Chinese Medicine Resources(2060302)the Science and Technology Development Program of Shanghai University of Traditional Chinese Medicine(23KFL045,23KFL051).
文摘Penthorum chinense Pursh has been used for centuries as an herbal medicine and food in East Asia.The main active substances in P.chinense are galloylated macrocyclic polyphenolic compounds,which have excellent medicinal properties.Galloylation and glycosylation are key steps in the formation of polyphenolic compounds,as the glycosylation of flavonoids is required for the acylation of flavonoid glycosides,and the glycosylation of gallic acid is necessary for its role as an acyl donor.Therefore,glycosylation to generate the acyl donor or acceptor is a core step in the biosynthesis of polyphenolic compounds.However,how this glycosylation occurs in P.chinense is unknown.In this study,we determined that the UDP-glucose transferase PcUGT84A82 mediates the glycosylation of gallic acid and pinocembrin to produce 1-O-Galloyl-β-D-glucose and pinocembroside,respectively.Metabolic profiling of polyphenolic compounds using UHPLC-ESI–Q-TOF/MS revealed high levels of polyphenols in flowers,leaves,and roots,and low levels in stems of P.chinense.We performed isoform-sequencing(Iso-seq)to assemble a full-length transcriptome of P.chinense,from which we identified 58 UGT family members.PcUGT84A82 is highly similar to functional UGTs in other plant species,and PcUGT84A82 transcript levels were positively correlated with the levels of various polyphenolic compounds.We validated the function of PcUGT84A82 via in vitro enzyme assays and transient expression in Nicotiana benthamiana leaves.Subcellular localization tests showed that PcUGT84A82 localizes to the nucleus and cytoplasm.In summary,PcUGT84A82 catalyzes the conversion of gallic acid to 1-O-Galloyl-β-D-glucose as the acyl donor and pinocembrin to pinocembroside as the acyl acceptor,mediating the biosynthesis of galloylated macrocyclic polyphenolic compounds in P.chinense.These findings lay the foundation for elucidating the entire biosynthetic pathway of active polyphenols in this important herbal plant species.
基金funded by Joint Funds of the National Natural Science Foundation of China(Grant No.U23A20671)the Major Project of Inner Mongolia Science and Technology(Grant No.2021ZD0034)the Creative Groups of Natural Science Foundation of Hubei Province,China(Grant No.2021CFA030).
文摘While injection-induced seismicity has been widely studied,its implications for CO_(2)geological storage require reevaluation due to distinct fluid-rock interactions.This study develops a coupled hydromechanical model incorporating rate-and-state friction laws to investigate fault reactivation mechanisms during early-stage CO_(2)injection.The competing effects of pore pressure diffusion and fluid pressurization are systematically investigated,considering three key factors:permeability variations within fault damage zones,normal stress variation coefficients,and injection parameters.Numerical simulations reveal that slower CO_(2)migration causes limited pressure perturbation(<0.3 MPa over 15 d)compared to single-phase fluid injection.Fluid pressurization enhances fault strength and delays reactivation,though this stabilizing effect diminishes in low-permeability damage zones.Highly permeable damage zones promote larger rupture areas despite strengthening from pressurization,as reduced effective stress accelerates failure.Paradoxically,while fluid pressurization increases fault strength,it simultaneously elevates seismic risk through amplified stress drops during slip events.Temporal analysis shows that fluid pressurization dominates initial fault response,while sustained pore pressure diffusion ultimately drives reactivation.Increased normal stress variation coefficients and injection rates accelerate localized rupture initiation but restrict propagation due to non-critically stressed states.This discrepancy demonstrates that regions with positive Coulomb failure stress changes do not correlate well with actual slip zones.These findings highlight the critical interplay between transient pressurization effects and progressive pressure diffusion during early CO_(2)injection phases,providing crucial insights for seismic risk management in CO_(2)storage projects.
基金supported by the National Natural Science Foundation of China(22175136)the State Key Laboratory of Electrical Insulation and Power Equipment(EIPE23127)the Fundamental Research Funds for the Central Universities(xtr052024009).
文摘Metal hydrides with high hydrogen density provide promising hydrogen storage paths for hydrogen transportation.However,the requirement of highly pure H_(2)for re-hydrogenation limits its wide application.Here,amorphous Al_(2)O_(3)shells(10 nm)were deposited on the surface of highly active hydrogen storage material particles(MgH_(2)-ZrTi)by atomic layer deposition to obtain MgH_(2)-ZrTi@Al_(2)O_(3),which have been demonstrated to be air stable with selective adsorption of H_(2)under a hydrogen atmosphere with different impurities(CH_(4),O_(2),N_(2),and CO_(2)).About 4.79 wt% H_(2)was adsorbed by MgH_(2)-ZrTi@10nmAl_(2)O_(3)at 75℃under 10%CH_(4)+90%H_(2)atmosphere within 3 h with no kinetic or density decay after 5 cycles(~100%capacity retention).Furthermore,about 4 wt%of H_(2)was absorbed by MgH_(2)-ZrTi@10nmAl_(2)O_(3)under 0.1%O_(2)+0.4%N_(2)+99.5%H_(2)and 0.1%CO_(2)+0.4%N_(2)+99.5%H_(2)atmospheres at 100℃within 0.5 h,respectively,demonstrating the selective hydrogen absorption of MgH_(2)-ZrTi@10nmAl_(2)O_(3)in both oxygen-containing and carbon dioxide-containing atmospheres hydrogen atmosphere.The absorption and desorption curves of MgH_(2)-ZrTi@10nmAl_(2)O_(3)with and without absorption in pure hydrogen and then in 21%O_(2)+79%N_(2)for 1 h were found to overlap,further confirming the successful shielding effect of Al_(2)O_(3)shells against O_(2)and N_(2).The MgH_(2)-ZrTi@10nmAl_(2)O_(3)has been demonstrated to be air stable and have excellent selective hydrogen absorption performance under the atmosphere with CH_(4),O_(2),N_(2),and CO_(2).
基金Project supported by the National Natural Science Foundation of China(Grant Nos.52225207 and 52350001)the Shanghai Pilot Program for Basic Research–Fudan University 21TQ1400100(Grant No.21TQ006)the Shanghai Municipal Science and Technology Major Project(Grant No.2019SHZDZX01)。
文摘When two layers of graphene are stacked with a twist angle of approximately 1.1°,strong interlayer coupling gives rise to a pair of flat bands in twisted bilayer graphene(TBG),resulting in pronounced electron–electron interactions.At half filling of the flat bands,TBG exhibits correlated insulating states.Here,we investigate the electrical transport properties of heterostructures composed of TBG and the antiferromagnetic insulator chromium oxychloride(CrOCl),and propose a strategy to modulate the correlated insulating states in TBG.During the transition from a conventional phase to a strong interfacial coupling phase,kink-like features are observed in the charge neutrality point(CNP),correlated insulating state,and band insulating state.Under a perpendicular magnetic field,the system exhibits broadened quantum Hall plateaus in the strong interfacial coupling regime.Electrons localized in the CrOCl layer screen the bottom gate,rendering the carrier density in TBG less sensitive to variations in the bottom gate voltage.These phenomena are well captured by a charge-transfer model between TBG and CrOCl.Our results provide insights into the control of electronic correlations and topological states in graphene moirésystems via interfacial charge coupling.
基金funded by the National Natural Science Foundation of China(82274044,82304663)National Key Research and Development Program(2022YFC3501802,2022YFC3501803,and 2022YFC3501804)+1 种基金the Scientific and technological innovation project of China Academy of Chinese Medical Sciences(CI2023E002,CI2024E003)the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ13-YQ-049,ZZ16-XRZ-072,ZZ17-YQ-025,ZXKT22052,and ZXKT22060).
文摘Keystone taxa are critical for microbial community homeostasis and ecological niche interactions.However,the functions and genomic traits of endophytic keystone fungi in plant tissues remain unclear.Via network analysis,this study identified keystone fungi Plectosphaerella(Plec)and Cladosporium(Clad)in roots/leaves of medicinal Panax plants(P.ginseng,P.quinquefolius,P.notoginseng).Both correlated strongly positively with ginsenoside Rd content in respective tissues(ρ>0.6,p<0.001).Co-cultivation confirmed their ability to convert ginsenoside Rb1 to Rd,linked toβ-glucosidase activity.Whole-genome sequencing/assembly/evolutionary analysis of the two strains elucidated genomic features for their keystone roles and saponin biotransformation.Genome mining found multiple GH3 genes(potential saponin transformers)in both;11(Plec)and 5(Clad)were upregulated by cellobiose.Gene family phylogenetic analysis showed expanded transmembrane transport and environmental response functions.Both also had abundant secondary metabolic gene clusters and secretome genes,linking biotic interaction functions to their keystone roles.In summary,this study shows Panax endophytic keystone fungi can participate in ginsenoside biotransformation and clarifies their genomic traits,offering insights for functional endophytic fungal resource development.
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences (Grant Nos.XDB28000000 and XDB0460000)the Quantum Science and Technology-National Science and Technology Major Project (Grant No.2021ZD0302600)the National Key Research and Development Program of China(Grant No.2024YFA1409002)。
文摘The hybridization gap in strained-layer InAs/In_(x)Ga_(1−x) Sb quantum spin Hall insulators(QSHIs)is significantly enhanced compared to binary InAs/GaSb QSHI structures,where the typical indium composition,x,ranges between 0.2 and 0.4.This enhancement prompts a critical question:to what extent can quantum wells(QWs)be strained while still preserving the fundamental QSHI phase?In this study,we demonstrate the controlled molecular beam epitaxial growth of highly strained-layer QWs with an indium composition of x=0.5.These structures possess a substantial compressive strain within the In_(0.5)Ga_(0.5)Sb QW.Detailed crystal structure analyses confirm the exceptional quality of the resulting epitaxial films,indicating coherent lattice structures and the absence of visible dislocations.Transport measurements further reveal that the QSHI phase in InAs/In_(0.5)Ga_(0.5)Sb QWs is robust and protected by time-reversal symmetry.Notably,the edge states in these systems exhibit giant magnetoresistance when subjected to a modest perpendicular magnetic field.This behavior is in agreement with the𝑍2 topological property predicted by the Bernevig–Hughes–Zhang model,confirming the preservation of topologically protected edge transport in the presence of enhanced bulk strain.
基金financially supported by the National Natural Science Foundation of China (22472199)Chinese Universities Scientific Fund (15055009)Central University Guided Funds for Building World-Class Universities (Disciplines) and Advancing Characteristic Development
文摘Electrocatalytic glucose oxidation to high-value chemicals provides a sustainable route for biomass valorization.NiCo-based catalysts have emerged as promising candidates for glucose oxidation reaction owing to the intrinsic activity of Ni and Co catalytic centers.However,the dynamic evolution and atomic-scale synergy between these centers remain elusive.Herein,we fabricated NiCo_(2)O_(4)nanosheets supported on nickel foam,where Ni preferentially occupies tetrahedral sites to regulate the electronic configuration of octahedral Co.Experimental and theoretical results demonstrate that the incorporation of tetrahedral Ni induces low-to-intermediate spin transition in octahedral Co,thereby optimizing eg orbital occupancy and stabilizing active sites.This spin-state engineering establishes Ni-Co synergistic catalytic centers for the selective oxidation of glucose to formate(FA).At higher potential(≥1.4 V vs.RHE),octahedral Co undergoes reconstruction into excessive active CoOOH and CoO_(2)species,resulting in glucose overoxidation to CO_(2)and intensified competitive oxygen evolution.In contrast,at lower potentials(<1.4 V vs.RHE),tetrahedral Ni facilitates electron delocalization across the Ni–O–Co lattice,thereby stabilizing octahedral Co for glucose adsorption and oxidation.Subsequently,a coupled electrocatalytic system was constructed,achieving 80.7%FA yield with 91.3%Faradaic efficiency(FE)at NiCo_(2)O_(4)anode and H2 evolution rate of 696μmol h^(−1)with 99.9%FE at Pt cathode for 2 h under 1.35 V vs.RHE.This work provides a deep insight into spin-state regulation of the catalytic center,offering valuable guidance for rational catalyst design.
