Objective To investigate the serum total IgE （tlgE） and specific IgE （slgE） to common allergens among allergic patients in Guangzhou, China. Methods 7 085 patients were examined for tlgE and slgE to 15 allergens, ...Objective To investigate the serum total IgE （tlgE） and specific IgE （slgE） to common allergens among allergic patients in Guangzhou, China. Methods 7 085 patients were examined for tlgE and slgE to 15 allergens, based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay. Results 3 758 （53.04%） patients tested positive for tlgE, and 4 640 （65.49%） for slgE. Der pteronyssinus, Derfarinae, eggs, and cow＇s milk were the most common allergens leading to higher positive rates of slgE responses. Several peaks of sensitization were： Der pteronyssinus, Derfarinae, and Blomia tropicalis at age 10-12; cow＇s milk at age below 3; eggs at age 4-6. The mean level and positive rate of tlgE tended to increase in subjects sensitized to more allergens. Sensitization to Der pteronyssinus （OR, 1.6; P〈O.05）, Der farinae （OR, 1.5; P〈O.05）, Blomia tropicalis （OR, 1.4; P〈O.05）, Blattella germanica （OR, 1.5; P〈O.05）, cow＇s milk （OR, 1.3; P〈O.05）, and soy beans （OR, 2.0; P〈O.05） were independently correlated with allergy-related conditions in preliminary diagnosis. Conclusion The major allergens in Guangzhou include Derpteronyssinus, Derfarinae, cow＇s milk, and eggs. Sensitization to these allergens appears to be predictors of allergy-related disorder.展开更多
In recent years,the usage,management and benefit of large-scale scientific research instruments and equipment in scientific research institutes have been a leading issue in the management of scientific research instit...In recent years,the usage,management and benefit of large-scale scientific research instruments and equipment in scientific research institutes have been a leading issue in the management of scientific research institutes.Within the scope of equipment budget,it is necessary for each equipment acquisition team to conduct a round of communication,coordination and negotiation with suppliers in order to improve the cost performance of equipment procurement and maximize the performance index to meet the needs of scientific research.By introducing the practical experience of the State Key Laboratory in purchasing imported equipment and managing large-scale instruments,this paper probes into the management process of the imported large-scale scientific research tax-free equipment of scientific research institutes,and explores the system and methods to guarantee and improve the efficiency of large-scale instruments in scientific research institutes from the aspects of policy,funds and technology.展开更多
The State Key Laboratory of Natural and Biomimetic Drugs was approved for a funding of nearly 100 million yuan specifically aimed at the purchase and maintenance of equipment and instruments from 2018 to 2020,which is...The State Key Laboratory of Natural and Biomimetic Drugs was approved for a funding of nearly 100 million yuan specifically aimed at the purchase and maintenance of equipment and instruments from 2018 to 2020,which is a record high.The Laboratory focuses on two major directions of scientific research,the"basic scientific problems of drug resistance of complex components of natural products"and the"key biomimetic scientific problems of endogenous substances therapeutic functions".The selection of scientific instruments and equipment,trial production,upgrading,as well as high level of technical and management personnel allocation and other aspects are critical to meet the development needs of the Key Laboratory and to maintain the advantages and leading role in these two major directions of scientific research.展开更多
This year marks the tenth anniversary of the State Key Laboratory of Advanced Displays and Optoelectronics Technologies(SKLADOT)at the Hong Kong University of Science and Technology(HKUST).The predecessor of SKLADOT w...This year marks the tenth anniversary of the State Key Laboratory of Advanced Displays and Optoelectronics Technologies(SKLADOT)at the Hong Kong University of Science and Technology(HKUST).The predecessor of SKLADOT was the Center for Display Research(CDR)which was started in 1995.Thus display research has a long history at HKUST.展开更多
·Prof.XIONG,could you please give us a brief introduction to SKLMCMS？Director XIONG Ke：The State Key Laboratory of Mechanics and Control of Mechanical Structures（SKLMCMS）was established with the approval of t...·Prof.XIONG,could you please give us a brief introduction to SKLMCMS？Director XIONG Ke：The State Key Laboratory of Mechanics and Control of Mechanical Structures（SKLMCMS）was established with the approval of the Ministry of Science and Technology of the People’s Republic of China in October 2011.The laboratory is located at Nanjing University of Aeronautics and Astronautics（NUAA）.展开更多
Phase-matching quantum-key distribution(PM-QKD)has achieved significant results in various practical applications.However,real-time communication requires dynamic adjustment and optimization of key parameters during c...Phase-matching quantum-key distribution(PM-QKD)has achieved significant results in various practical applications.However,real-time communication requires dynamic adjustment and optimization of key parameters during communication.In this letter,we predict the PM-QKD parameters using nature-inspired algorithms(NIAs).The results are obtained from an exhaustive traversal algorithm(ETA),which serves as a benchmark.We mainly study the parameter optimization effects of the two NIAs:ant colony optimization(ACO)and the genetic algorithm(GA).The configuration of the inherent parameters of these algorithms in the decoy-state PM-QKD is also discussed.The simulation results indicate that the parameters obtained by the ACO exhibit superior convergence and stability,whereas the GA results are relatively scattered.Nevertheless,more than 97%of the key rates predicted by both algorithms are highly consistent with the optimal key rate.Moreover,the relative error of the key rates remained below 10%.Furthermore,NIAs maintain power consumption below 8 W and require three orders of magnitude less computing time than ETA.展开更多
High-nickel cathode,LiNi0.8Co0.1Mn0.1O_(2)(NCM811),and sulfide-solid electrolyte are a promising combination for all-solid-state lithium batteries(ASSLBs).However,this combination faces the issue of interfacial instab...High-nickel cathode,LiNi0.8Co0.1Mn0.1O_(2)(NCM811),and sulfide-solid electrolyte are a promising combination for all-solid-state lithium batteries(ASSLBs).However,this combination faces the issue of interfacial instability between the cathode and electrolyte.Given the surface alkalinity of NCM811,we propose a strategy to construct a solid-polymer-electrolyte(SPE)interphase on NCM811 surface by leveraging the surface alkaline residues to nucleophilically initiate the in-situ ring-opening polymerization of cyclic organic molecules.As a proof-of-concept,this study demonstrates that the ring-opening copolymerization of 1,3-dioxolane and maleic anhydride produces a homogeneous,compact,and conformal SPE layer on NCM811 surface to prevent the cathode from contact and reaction with Li6PS5Cl solid-state electrolyte.Consequently,the SPE-modified-NCM811 in ASSLBs exhibits high capacities of 193.5 mA h g^(-1) at 0.2 C,160.9 mA h g^(-1) at 2.0 C and 112.3 mA h g^(-1) at 10 C,and particularly,excellent long-term cycling stabilities over 11000 cycles with a 71.95%capacity retention at 10 C at 25℃,as well as a remained capacity of 117.9 mA h g^(-1) after 8000 cycles at 30 C at 60℃,showing a great application prospect.This study provides a new route for creating electrochemically and structurally stable solid-solid interfaces for ASSLBs.展开更多
While injection-induced seismicity has been widely studied,its implications for CO_(2)geological storage require reevaluation due to distinct fluid-rock interactions.This study develops a coupled hydromechanical model...While injection-induced seismicity has been widely studied,its implications for CO_(2)geological storage require reevaluation due to distinct fluid-rock interactions.This study develops a coupled hydromechanical model incorporating rate-and-state friction laws to investigate fault reactivation mechanisms during early-stage CO_(2)injection.The competing effects of pore pressure diffusion and fluid pressurization are systematically investigated,considering three key factors:permeability variations within fault damage zones,normal stress variation coefficients,and injection parameters.Numerical simulations reveal that slower CO_(2)migration causes limited pressure perturbation(<0.3 MPa over 15 d)compared to single-phase fluid injection.Fluid pressurization enhances fault strength and delays reactivation,though this stabilizing effect diminishes in low-permeability damage zones.Highly permeable damage zones promote larger rupture areas despite strengthening from pressurization,as reduced effective stress accelerates failure.Paradoxically,while fluid pressurization increases fault strength,it simultaneously elevates seismic risk through amplified stress drops during slip events.Temporal analysis shows that fluid pressurization dominates initial fault response,while sustained pore pressure diffusion ultimately drives reactivation.Increased normal stress variation coefficients and injection rates accelerate localized rupture initiation but restrict propagation due to non-critically stressed states.This discrepancy demonstrates that regions with positive Coulomb failure stress changes do not correlate well with actual slip zones.These findings highlight the critical interplay between transient pressurization effects and progressive pressure diffusion during early CO_(2)injection phases,providing crucial insights for seismic risk management in CO_(2)storage projects.展开更多
Metal hydrides with high hydrogen density provide promising hydrogen storage paths for hydrogen transportation.However,the requirement of highly pure H_(2)for re-hydrogenation limits its wide application.Here,amorphou...Metal hydrides with high hydrogen density provide promising hydrogen storage paths for hydrogen transportation.However,the requirement of highly pure H_(2)for re-hydrogenation limits its wide application.Here,amorphous Al_(2)O_(3)shells(10 nm)were deposited on the surface of highly active hydrogen storage material particles(MgH_(2)-ZrTi)by atomic layer deposition to obtain MgH_(2)-ZrTi@Al_(2)O_(3),which have been demonstrated to be air stable with selective adsorption of H_(2)under a hydrogen atmosphere with different impurities(CH_(4),O_(2),N_(2),and CO_(2)).About 4.79 wt% H_(2)was adsorbed by MgH_(2)-ZrTi@10nmAl_(2)O_(3)at 75℃under 10%CH_(4)+90%H_(2)atmosphere within 3 h with no kinetic or density decay after 5 cycles(~100%capacity retention).Furthermore,about 4 wt%of H_(2)was absorbed by MgH_(2)-ZrTi@10nmAl_(2)O_(3)under 0.1%O_(2)+0.4%N_(2)+99.5%H_(2)and 0.1%CO_(2)+0.4%N_(2)+99.5%H_(2)atmospheres at 100℃within 0.5 h,respectively,demonstrating the selective hydrogen absorption of MgH_(2)-ZrTi@10nmAl_(2)O_(3)in both oxygen-containing and carbon dioxide-containing atmospheres hydrogen atmosphere.The absorption and desorption curves of MgH_(2)-ZrTi@10nmAl_(2)O_(3)with and without absorption in pure hydrogen and then in 21%O_(2)+79%N_(2)for 1 h were found to overlap,further confirming the successful shielding effect of Al_(2)O_(3)shells against O_(2)and N_(2).The MgH_(2)-ZrTi@10nmAl_(2)O_(3)has been demonstrated to be air stable and have excellent selective hydrogen absorption performance under the atmosphere with CH_(4),O_(2),N_(2),and CO_(2).展开更多
Electrocatalytic glucose oxidation to high-value chemicals provides a sustainable route for biomass valorization.NiCo-based catalysts have emerged as promising candidates for glucose oxidation reaction owing to the in...Electrocatalytic glucose oxidation to high-value chemicals provides a sustainable route for biomass valorization.NiCo-based catalysts have emerged as promising candidates for glucose oxidation reaction owing to the intrinsic activity of Ni and Co catalytic centers.However,the dynamic evolution and atomic-scale synergy between these centers remain elusive.Herein,we fabricated NiCo_(2)O_(4)nanosheets supported on nickel foam,where Ni preferentially occupies tetrahedral sites to regulate the electronic configuration of octahedral Co.Experimental and theoretical results demonstrate that the incorporation of tetrahedral Ni induces low-to-intermediate spin transition in octahedral Co,thereby optimizing eg orbital occupancy and stabilizing active sites.This spin-state engineering establishes Ni-Co synergistic catalytic centers for the selective oxidation of glucose to formate(FA).At higher potential(≥1.4 V vs.RHE),octahedral Co undergoes reconstruction into excessive active CoOOH and CoO_(2)species,resulting in glucose overoxidation to CO_(2)and intensified competitive oxygen evolution.In contrast,at lower potentials(<1.4 V vs.RHE),tetrahedral Ni facilitates electron delocalization across the Ni–O–Co lattice,thereby stabilizing octahedral Co for glucose adsorption and oxidation.Subsequently,a coupled electrocatalytic system was constructed,achieving 80.7%FA yield with 91.3%Faradaic efficiency(FE)at NiCo_(2)O_(4)anode and H2 evolution rate of 696μmol h^(−1)with 99.9%FE at Pt cathode for 2 h under 1.35 V vs.RHE.This work provides a deep insight into spin-state regulation of the catalytic center,offering valuable guidance for rational catalyst design.展开更多
The methanol oxidation reaction(MOR)to formic acid offers a promising alternative to the anodic oxygen evolution reaction(OER)in water electrolysis.However,the development of efficient and cost-effective catalysts rem...The methanol oxidation reaction(MOR)to formic acid offers a promising alternative to the anodic oxygen evolution reaction(OER)in water electrolysis.However,the development of efficient and cost-effective catalysts remains a primary challenge.In this study,an enhancement in catalytic MOR performance is achieved through the incorporation of Mn atoms with unsaturated t_(2g)orbitals into Ni_(3)Se_(4).Comprehensive experimental analyses and theoretical calculations reveal that substituting Ni with Mn induces strong electron-withdrawing effects,effectively modulating the local coordination environment of the metal centers.The presence of Mn also elongates Ni–Se(O)bonds,which reduces eg orbital occupancy and modifies the spin state of the material.Electrochemical measurements demonstrate that electrodes based on this optimized material exhibit a high spin state and deliver excellent catalytic activity,achieving a MOR current density up to∼190 mA cm^(−2)at 1.6 V.This performance enhancement is attributed to the favorable electronic configuration and reduced reaction energy barriers associated with the high-spin state.展开更多
Surface passivation via two-dimensional(2D)perovskite has emerged as a promising strategy to enhance the performance of perovskite solar cells(PSCs)due to the effective compensation of interfacial states.However,the i...Surface passivation via two-dimensional(2D)perovskite has emerged as a promising strategy to enhance the performance of perovskite solar cells(PSCs)due to the effective compensation of interfacial states.However,the in situ grown 2D perovskite passivation layers typically comprise a mixture of multiple dimensionalities at the interface,where band alignment has only been portrayed qualitatively and empirically.Herein,the interface states for precisely phase-tailored 2D perovskite passivated PSCs are quantitatively investigated.In comparison to traditional passivation molecules,2D perovskite layers based on 4-trifluoromethyl-phenylethylammonium iodide(CF3PEAI)exhibit an increased work function,introducing desirable downward band bending to eliminate the Schottky Barrier.Furthermore,precisely phase-tailored 2D layers could modulate the interface trap density and energetics.The n=1 film delivers optimal performance with a hole extraction efficiency of 95.1%.The optimized n-i-p PSCs in the two-step method significantly improve PCE to 25.40%,along with enhanced photostability and negligible hysteresis.It highlights that tailoring in the composition and phase distribution of the 2D perovskite layer could modulate the interface states at the 2D/3D interface.展开更多
Ferroptosis,a type of cell death that mainly involves iron metabolism imbalance and lipid peroxidation,is strongly correlated with the phagocytic response caused by bleeding after spinal cord injury.Thus,in this study...Ferroptosis,a type of cell death that mainly involves iron metabolism imbalance and lipid peroxidation,is strongly correlated with the phagocytic response caused by bleeding after spinal cord injury.Thus,in this study,bulk RNA sequencing data(GSE47681 and GSE5296)and single-cell RNA sequencing data(GSE162610)were acquired from gene expression databases.We then conducted differential analysis and immune infiltration analysis.Atf3 and Piezo1 were identified as key ferroptosis genes through random forest and least absolute shrinkage and selection operator algorithms.Further analysis of single-cell RNA sequencing data revealed a close relationship between ferroptosis and cell types such as macrophages/microglia and their intrinsic state transition processes.Differences in transcription factor regulation and intercellular communication networks were found in ferroptosis-related cells,confirming the high expression of Atf3 and Piezo1 in these cells.Molecular docking analysis confirmed that the proteins encoded by these genes can bind cycloheximide.In a mouse model of T8 spinal cord injury,low-dose cycloheximide treatment was found to improve neurological function,decrease levels of the pro-inflammatory cytokine inducible nitric oxide synthase,and increase levels of the anti-inflammatory cytokine arginase 1.Correspondingly,the expression of the ferroptosis-related gene Gpx4 increased in macrophages/microglia,while the expression of Acsl4 decreased.Our findings reveal the important role of ferroptosis in the treatment of spinal cord injury,identify the key cell types and genes involved in ferroptosis after spinal cord injury,and validate the efficacy of potential drug therapies,pointing to new directions in the treatment of spinal cord injury.展开更多
The power system is experiencing a higher penetration of renewable energy generations(REGs).The short circuit ratio(SCR)and the grid impedance ratio(GIR)are two indices to quantify the system strength of the power sys...The power system is experiencing a higher penetration of renewable energy generations(REGs).The short circuit ratio(SCR)and the grid impedance ratio(GIR)are two indices to quantify the system strength of the power system with REGs.In this paper,the critical short circuit ratio(CSCR)is defined as the corresponding SCR when the system voltage is in the critical stable state.Through static voltage stability analysis,the mathematical expression of the CSCR considering the impact of GIR is derived.The maximum value of CSCR is adopted as the critical value to distinguish the weak power system.Based on the static equivalent circuit analysis,it is proved that the CSCR is still effective to evaluate critical system strength considering the interactive impact among REGs.Finally,we find that the GIR can be neglected and the SCR can be used individually to evaluate the system strength when SCR>2 or GIR>5.The correctness and rationality of the CSCR and its critical value are validated on ADPSS.展开更多
We report a fiber-based four-state discrete modulation continuous variable quantum key distribution system based on homodyne detection.A secret key rate of 1 kbit/s is achieved at a transmission distance of 30.2 km.Tw...We report a fiber-based four-state discrete modulation continuous variable quantum key distribution system based on homodyne detection.A secret key rate of 1 kbit/s is achieved at a transmission distance of 30.2 km.Two factors that result in the excess noises of the quantum key distribution system are analyzed.The first is the relative phase dithering between the signal and local fields,and the second is the local field leakage into the signal field due to the scattering process that depolarizes the local field.It is found that the latter has a significant impact on the excess noise,which is the main limiting factor to the long-distance secure quantum transmission.Some protocols are also given to decrease the excess noise effectively.展开更多
We construct a circuit based on PBS and CNOT gates, which can be used to determine whether the input pulse is empty or not according to the detection result of the auxiliary state, while the input state will not be ch...We construct a circuit based on PBS and CNOT gates, which can be used to determine whether the input pulse is empty or not according to the detection result of the auxiliary state, while the input state will not be changed. The circuit can be treated as a pre-detection device. Equipping the pre-detection device in the front of the receiver of the quantum key distribution （QKD） can reduce the influence of the dark count of the detector, hence increasing the secure communication distance significantly. Simulation results show that the secure communication distance can reach 516 km and 479 km for QKD with perfect single photon source and decoy-state QKD with weak coherent photon source, respectively.展开更多
For the beam splitter attack strategy against quantum key distribution using two-mode squeezed states, the analytical expression of the optimal beam splitter parameter is provided in this paper by applying the Shannon...For the beam splitter attack strategy against quantum key distribution using two-mode squeezed states, the analytical expression of the optimal beam splitter parameter is provided in this paper by applying the Shannon information theory. The theoretical secret information rate after error correction and privacy amplification is given in terms of the squeezed parameter and channel parameters. The results show that the two-mode squeezed state quantum key distribution is secure against an optimal beam splitter attack.展开更多
In free space channel,continuous-variable quantum key distribution(CV-QKD)using polarized coherent-states can not only make the signal state more stable and less susceptible to interference based on the polarization n...In free space channel,continuous-variable quantum key distribution(CV-QKD)using polarized coherent-states can not only make the signal state more stable and less susceptible to interference based on the polarization non-sensitive of the free-space channel,but also reduce the noise introduced by phase interference.However,arbitrary continuous modulation can not be carried out in the past polarization coding,resulting in that the signal state can not obtain arbitrary continuous value in Poincare space,and the security analysis of CV-QKD using polarized coherent-states in free space is not complete.Here we propose a new modulation method to extend the modulation range of signal states with an optical-fiber-based polarization controller.In particular,in terms of the main influence factors in the free-space channel,we utilize the beam extinction and elliptical model when considering the transmittance and adopt the formulation of secret key rate.In addition,the performance of the proposed scheme under foggy weather is also taken into consideration to reveal the influence of severe weather.Numerical simulation shows that the proposed scheme is seriously affected by attenuation under foggy weather.The protocol fails when visibility is less than 1 km.At the same time,the wavelength can affect the performance of the proposed scheme.Specifically,under foggy weather,the longer the wavelength,the smaller the attenuation coefficient,and the better the transmission performance.Our proposed scheme can expand the modulation range of signal state,and supplement the security research of the scheme in the free-space channel,thus can provide theoretical support for subsequent experiments.展开更多
An efficient quantum key distribution （QKD） protocol with orthogonal product states in the 3 3 Hilbert space is presented. The sender, Alice, disorders the orthogonal product state sequence and sends it to Bob. Aft...An efficient quantum key distribution （QKD） protocol with orthogonal product states in the 3 3 Hilbert space is presented. The sender, Alice, disorders the orthogonal product state sequence and sends it to Bob. After Alice has published the matching information of the particle sequence, Bob recovers the correct correspondences and makes an orthogonal measurement on the orthogonal product states to obtain the information sent by Alice. Finally, security analysis is also made.展开更多
To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified ...To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming alternative.Among the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale applications.However,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their applications.This review provides a comprehensive overview of recent research advancements in OICSEs.Specifically,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically discussed.The lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic perspective.Besides,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of OICSEs.Finally,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.展开更多
基金supported by Guangdong Industry Technology and Development Fund(No.2011B061200040)Science Foundation of Guangzhou Medical Univesity(Project No.2013A06)Guangdong Natural Science Foundation(No.S2013010014728)
文摘Objective To investigate the serum total IgE （tlgE） and specific IgE （slgE） to common allergens among allergic patients in Guangzhou, China. Methods 7 085 patients were examined for tlgE and slgE to 15 allergens, based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay. Results 3 758 （53.04%） patients tested positive for tlgE, and 4 640 （65.49%） for slgE. Der pteronyssinus, Derfarinae, eggs, and cow＇s milk were the most common allergens leading to higher positive rates of slgE responses. Several peaks of sensitization were： Der pteronyssinus, Derfarinae, and Blomia tropicalis at age 10-12; cow＇s milk at age below 3; eggs at age 4-6. The mean level and positive rate of tlgE tended to increase in subjects sensitized to more allergens. Sensitization to Der pteronyssinus （OR, 1.6; P〈O.05）, Der farinae （OR, 1.5; P〈O.05）, Blomia tropicalis （OR, 1.4; P〈O.05）, Blattella germanica （OR, 1.5; P〈O.05）, cow＇s milk （OR, 1.3; P〈O.05）, and soy beans （OR, 2.0; P〈O.05） were independently correlated with allergy-related conditions in preliminary diagnosis. Conclusion The major allergens in Guangzhou include Derpteronyssinus, Derfarinae, cow＇s milk, and eggs. Sensitization to these allergens appears to be predictors of allergy-related disorder.
文摘In recent years,the usage,management and benefit of large-scale scientific research instruments and equipment in scientific research institutes have been a leading issue in the management of scientific research institutes.Within the scope of equipment budget,it is necessary for each equipment acquisition team to conduct a round of communication,coordination and negotiation with suppliers in order to improve the cost performance of equipment procurement and maximize the performance index to meet the needs of scientific research.By introducing the practical experience of the State Key Laboratory in purchasing imported equipment and managing large-scale instruments,this paper probes into the management process of the imported large-scale scientific research tax-free equipment of scientific research institutes,and explores the system and methods to guarantee and improve the efficiency of large-scale instruments in scientific research institutes from the aspects of policy,funds and technology.
文摘The State Key Laboratory of Natural and Biomimetic Drugs was approved for a funding of nearly 100 million yuan specifically aimed at the purchase and maintenance of equipment and instruments from 2018 to 2020,which is a record high.The Laboratory focuses on two major directions of scientific research,the"basic scientific problems of drug resistance of complex components of natural products"and the"key biomimetic scientific problems of endogenous substances therapeutic functions".The selection of scientific instruments and equipment,trial production,upgrading,as well as high level of technical and management personnel allocation and other aspects are critical to meet the development needs of the Key Laboratory and to maintain the advantages and leading role in these two major directions of scientific research.
文摘This year marks the tenth anniversary of the State Key Laboratory of Advanced Displays and Optoelectronics Technologies(SKLADOT)at the Hong Kong University of Science and Technology(HKUST).The predecessor of SKLADOT was the Center for Display Research(CDR)which was started in 1995.Thus display research has a long history at HKUST.
文摘·Prof.XIONG,could you please give us a brief introduction to SKLMCMS？Director XIONG Ke：The State Key Laboratory of Mechanics and Control of Mechanical Structures（SKLMCMS）was established with the approval of the Ministry of Science and Technology of the People’s Republic of China in October 2011.The laboratory is located at Nanjing University of Aeronautics and Astronautics（NUAA）.
基金supported by the State Key Laboratory of Information Photonics and Optical Communications(Beijing University of Posts and Telecommunications)No.IPOC2021ZT10BUPT Excellent Ph.D.Students Foundation(Grant No.CX2023207)the BUPT innovation and entrepreneurship support program No.2024-YC-A188。
文摘Phase-matching quantum-key distribution(PM-QKD)has achieved significant results in various practical applications.However,real-time communication requires dynamic adjustment and optimization of key parameters during communication.In this letter,we predict the PM-QKD parameters using nature-inspired algorithms(NIAs).The results are obtained from an exhaustive traversal algorithm(ETA),which serves as a benchmark.We mainly study the parameter optimization effects of the two NIAs:ant colony optimization(ACO)and the genetic algorithm(GA).The configuration of the inherent parameters of these algorithms in the decoy-state PM-QKD is also discussed.The simulation results indicate that the parameters obtained by the ACO exhibit superior convergence and stability,whereas the GA results are relatively scattered.Nevertheless,more than 97%of the key rates predicted by both algorithms are highly consistent with the optimal key rate.Moreover,the relative error of the key rates remained below 10%.Furthermore,NIAs maintain power consumption below 8 W and require three orders of magnitude less computing time than ETA.
基金supported by the National Key R&D Program of China(2021YFB3800300).
文摘High-nickel cathode,LiNi0.8Co0.1Mn0.1O_(2)(NCM811),and sulfide-solid electrolyte are a promising combination for all-solid-state lithium batteries(ASSLBs).However,this combination faces the issue of interfacial instability between the cathode and electrolyte.Given the surface alkalinity of NCM811,we propose a strategy to construct a solid-polymer-electrolyte(SPE)interphase on NCM811 surface by leveraging the surface alkaline residues to nucleophilically initiate the in-situ ring-opening polymerization of cyclic organic molecules.As a proof-of-concept,this study demonstrates that the ring-opening copolymerization of 1,3-dioxolane and maleic anhydride produces a homogeneous,compact,and conformal SPE layer on NCM811 surface to prevent the cathode from contact and reaction with Li6PS5Cl solid-state electrolyte.Consequently,the SPE-modified-NCM811 in ASSLBs exhibits high capacities of 193.5 mA h g^(-1) at 0.2 C,160.9 mA h g^(-1) at 2.0 C and 112.3 mA h g^(-1) at 10 C,and particularly,excellent long-term cycling stabilities over 11000 cycles with a 71.95%capacity retention at 10 C at 25℃,as well as a remained capacity of 117.9 mA h g^(-1) after 8000 cycles at 30 C at 60℃,showing a great application prospect.This study provides a new route for creating electrochemically and structurally stable solid-solid interfaces for ASSLBs.
基金funded by Joint Funds of the National Natural Science Foundation of China(Grant No.U23A20671)the Major Project of Inner Mongolia Science and Technology(Grant No.2021ZD0034)the Creative Groups of Natural Science Foundation of Hubei Province,China(Grant No.2021CFA030).
文摘While injection-induced seismicity has been widely studied,its implications for CO_(2)geological storage require reevaluation due to distinct fluid-rock interactions.This study develops a coupled hydromechanical model incorporating rate-and-state friction laws to investigate fault reactivation mechanisms during early-stage CO_(2)injection.The competing effects of pore pressure diffusion and fluid pressurization are systematically investigated,considering three key factors:permeability variations within fault damage zones,normal stress variation coefficients,and injection parameters.Numerical simulations reveal that slower CO_(2)migration causes limited pressure perturbation(<0.3 MPa over 15 d)compared to single-phase fluid injection.Fluid pressurization enhances fault strength and delays reactivation,though this stabilizing effect diminishes in low-permeability damage zones.Highly permeable damage zones promote larger rupture areas despite strengthening from pressurization,as reduced effective stress accelerates failure.Paradoxically,while fluid pressurization increases fault strength,it simultaneously elevates seismic risk through amplified stress drops during slip events.Temporal analysis shows that fluid pressurization dominates initial fault response,while sustained pore pressure diffusion ultimately drives reactivation.Increased normal stress variation coefficients and injection rates accelerate localized rupture initiation but restrict propagation due to non-critically stressed states.This discrepancy demonstrates that regions with positive Coulomb failure stress changes do not correlate well with actual slip zones.These findings highlight the critical interplay between transient pressurization effects and progressive pressure diffusion during early CO_(2)injection phases,providing crucial insights for seismic risk management in CO_(2)storage projects.
基金supported by the National Natural Science Foundation of China(22175136)the State Key Laboratory of Electrical Insulation and Power Equipment(EIPE23127)the Fundamental Research Funds for the Central Universities(xtr052024009).
文摘Metal hydrides with high hydrogen density provide promising hydrogen storage paths for hydrogen transportation.However,the requirement of highly pure H_(2)for re-hydrogenation limits its wide application.Here,amorphous Al_(2)O_(3)shells(10 nm)were deposited on the surface of highly active hydrogen storage material particles(MgH_(2)-ZrTi)by atomic layer deposition to obtain MgH_(2)-ZrTi@Al_(2)O_(3),which have been demonstrated to be air stable with selective adsorption of H_(2)under a hydrogen atmosphere with different impurities(CH_(4),O_(2),N_(2),and CO_(2)).About 4.79 wt% H_(2)was adsorbed by MgH_(2)-ZrTi@10nmAl_(2)O_(3)at 75℃under 10%CH_(4)+90%H_(2)atmosphere within 3 h with no kinetic or density decay after 5 cycles(~100%capacity retention).Furthermore,about 4 wt%of H_(2)was absorbed by MgH_(2)-ZrTi@10nmAl_(2)O_(3)under 0.1%O_(2)+0.4%N_(2)+99.5%H_(2)and 0.1%CO_(2)+0.4%N_(2)+99.5%H_(2)atmospheres at 100℃within 0.5 h,respectively,demonstrating the selective hydrogen absorption of MgH_(2)-ZrTi@10nmAl_(2)O_(3)in both oxygen-containing and carbon dioxide-containing atmospheres hydrogen atmosphere.The absorption and desorption curves of MgH_(2)-ZrTi@10nmAl_(2)O_(3)with and without absorption in pure hydrogen and then in 21%O_(2)+79%N_(2)for 1 h were found to overlap,further confirming the successful shielding effect of Al_(2)O_(3)shells against O_(2)and N_(2).The MgH_(2)-ZrTi@10nmAl_(2)O_(3)has been demonstrated to be air stable and have excellent selective hydrogen absorption performance under the atmosphere with CH_(4),O_(2),N_(2),and CO_(2).
基金financially supported by the National Natural Science Foundation of China(22472199)Chinese Universities Scientific Fund(15055009)and Central University Guided Funds for Building World-Class Universities(Disciplines)and Advancing Characteristic Development.The authors extend their gratitude to Theoretical and Computational Chemistry Team(from Scientific Compass www.shiyanjia.com)for providing invaluable assistance.
文摘Electrocatalytic glucose oxidation to high-value chemicals provides a sustainable route for biomass valorization.NiCo-based catalysts have emerged as promising candidates for glucose oxidation reaction owing to the intrinsic activity of Ni and Co catalytic centers.However,the dynamic evolution and atomic-scale synergy between these centers remain elusive.Herein,we fabricated NiCo_(2)O_(4)nanosheets supported on nickel foam,where Ni preferentially occupies tetrahedral sites to regulate the electronic configuration of octahedral Co.Experimental and theoretical results demonstrate that the incorporation of tetrahedral Ni induces low-to-intermediate spin transition in octahedral Co,thereby optimizing eg orbital occupancy and stabilizing active sites.This spin-state engineering establishes Ni-Co synergistic catalytic centers for the selective oxidation of glucose to formate(FA).At higher potential(≥1.4 V vs.RHE),octahedral Co undergoes reconstruction into excessive active CoOOH and CoO_(2)species,resulting in glucose overoxidation to CO_(2)and intensified competitive oxygen evolution.In contrast,at lower potentials(<1.4 V vs.RHE),tetrahedral Ni facilitates electron delocalization across the Ni–O–Co lattice,thereby stabilizing octahedral Co for glucose adsorption and oxidation.Subsequently,a coupled electrocatalytic system was constructed,achieving 80.7%FA yield with 91.3%Faradaic efficiency(FE)at NiCo_(2)O_(4)anode and H2 evolution rate of 696μmol h^(−1)with 99.9%FE at Pt cathode for 2 h under 1.35 V vs.RHE.This work provides a deep insight into spin-state regulation of the catalytic center,offering valuable guidance for rational catalyst design.
基金financially supported by the Sichuan Science and Technology Program(Grant No.2025NSFSC0139)the China Postdoctoral Science Foundation(Grant No.2023MD734228)+5 种基金The authors extend their gratitude to Ms.Zhou Yuke(from Scientific Compass www.shiyanjia.com)for providing invaluable assistance with the XPS analysis.ICN2 acknowledges funding from Generalitat de Catalunya 2021SGR00457This study is part of the Advanced Materials programme and was supported by MCIN with funding from European Union NextGenerationEU(PRTR-C17.I1)by Generalitat de Catalunya(In-CAEM Project)The authors thank the support from the project AMaDE(PID2023-149158OB-C43)funded by MCIN/AEI/10.13039/501100011033/and by“ERDF A way of making Europe”,by the“European Union”.ICN2 is supported by the Severo Ochoa program from Spanish MCIN/AEI(Grant No.:CEX2021-001214-S)is funded by the CERCA Programme/Generalitat de Catalunya.Part of the present work has been performed in the framework of Universitat Autònoma de Barcelona Materials Science PhD program.JY has received funding from the CSC-UAB PhD scholarship program.ICN2 is founding member of e-DREAM[87].
文摘The methanol oxidation reaction(MOR)to formic acid offers a promising alternative to the anodic oxygen evolution reaction(OER)in water electrolysis.However,the development of efficient and cost-effective catalysts remains a primary challenge.In this study,an enhancement in catalytic MOR performance is achieved through the incorporation of Mn atoms with unsaturated t_(2g)orbitals into Ni_(3)Se_(4).Comprehensive experimental analyses and theoretical calculations reveal that substituting Ni with Mn induces strong electron-withdrawing effects,effectively modulating the local coordination environment of the metal centers.The presence of Mn also elongates Ni–Se(O)bonds,which reduces eg orbital occupancy and modifies the spin state of the material.Electrochemical measurements demonstrate that electrodes based on this optimized material exhibit a high spin state and deliver excellent catalytic activity,achieving a MOR current density up to∼190 mA cm^(−2)at 1.6 V.This performance enhancement is attributed to the favorable electronic configuration and reduced reaction energy barriers associated with the high-spin state.
基金supported by the National Natural Science Foundation of China(Nos.62304111,62304110,22579136)the National Key Research and Development Program of China(2024YFE0201800)+6 种基金the China Postdoctoral Science Foundation(No.2024M761492)the Project of State Key Laboratory of Organic Electronics and Information Displays(Nos.GDX2022010009,GZR2023010046)the Natural Science Research Start-up Foundation of Recruiting Talents of Nanjing University of Posts and Telecommunications(No.NY223053)the Science and Technology Project of Jiangsu(Science and Technology Cooperation Project of HongKong,Macao and Taiwan,No.BZ2023059)Shaanxi Fundamental Science Research Project for Mathematics and Physics(No.22jSY015)Young Talent Fund of Xi'an Association for Science and Technology(No.959202313020)Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic Systems(No.2023B1212010003).
文摘Surface passivation via two-dimensional(2D)perovskite has emerged as a promising strategy to enhance the performance of perovskite solar cells(PSCs)due to the effective compensation of interfacial states.However,the in situ grown 2D perovskite passivation layers typically comprise a mixture of multiple dimensionalities at the interface,where band alignment has only been portrayed qualitatively and empirically.Herein,the interface states for precisely phase-tailored 2D perovskite passivated PSCs are quantitatively investigated.In comparison to traditional passivation molecules,2D perovskite layers based on 4-trifluoromethyl-phenylethylammonium iodide(CF3PEAI)exhibit an increased work function,introducing desirable downward band bending to eliminate the Schottky Barrier.Furthermore,precisely phase-tailored 2D layers could modulate the interface trap density and energetics.The n=1 film delivers optimal performance with a hole extraction efficiency of 95.1%.The optimized n-i-p PSCs in the two-step method significantly improve PCE to 25.40%,along with enhanced photostability and negligible hysteresis.It highlights that tailoring in the composition and phase distribution of the 2D perovskite layer could modulate the interface states at the 2D/3D interface.
基金supported by the National Natural Science Foundation of China,No.81972073(to HZ)a grant from the Taishan Scholars Program ofShandong Province-Young Taishan Scholars,No.tsqn201909197(to HZ)+1 种基金a grant from Tianjin Key Medical Discipline(Specialty)Construct Project,No.TJYXZDXK-027A(to SF)a grant from Academic Expert International Innovation Summit,No.22JRRCRC00010(to SF).
文摘Ferroptosis,a type of cell death that mainly involves iron metabolism imbalance and lipid peroxidation,is strongly correlated with the phagocytic response caused by bleeding after spinal cord injury.Thus,in this study,bulk RNA sequencing data(GSE47681 and GSE5296)and single-cell RNA sequencing data(GSE162610)were acquired from gene expression databases.We then conducted differential analysis and immune infiltration analysis.Atf3 and Piezo1 were identified as key ferroptosis genes through random forest and least absolute shrinkage and selection operator algorithms.Further analysis of single-cell RNA sequencing data revealed a close relationship between ferroptosis and cell types such as macrophages/microglia and their intrinsic state transition processes.Differences in transcription factor regulation and intercellular communication networks were found in ferroptosis-related cells,confirming the high expression of Atf3 and Piezo1 in these cells.Molecular docking analysis confirmed that the proteins encoded by these genes can bind cycloheximide.In a mouse model of T8 spinal cord injury,low-dose cycloheximide treatment was found to improve neurological function,decrease levels of the pro-inflammatory cytokine inducible nitric oxide synthase,and increase levels of the anti-inflammatory cytokine arginase 1.Correspondingly,the expression of the ferroptosis-related gene Gpx4 increased in macrophages/microglia,while the expression of Acsl4 decreased.Our findings reveal the important role of ferroptosis in the treatment of spinal cord injury,identify the key cell types and genes involved in ferroptosis after spinal cord injury,and validate the efficacy of potential drug therapies,pointing to new directions in the treatment of spinal cord injury.
基金supported by the Science and Technology Project of State Grid Corporation of China(No.XT71-20-014).
文摘The power system is experiencing a higher penetration of renewable energy generations(REGs).The short circuit ratio(SCR)and the grid impedance ratio(GIR)are two indices to quantify the system strength of the power system with REGs.In this paper,the critical short circuit ratio(CSCR)is defined as the corresponding SCR when the system voltage is in the critical stable state.Through static voltage stability analysis,the mathematical expression of the CSCR considering the impact of GIR is derived.The maximum value of CSCR is adopted as the critical value to distinguish the weak power system.Based on the static equivalent circuit analysis,it is proved that the CSCR is still effective to evaluate critical system strength considering the interactive impact among REGs.Finally,we find that the GIR can be neglected and the SCR can be used individually to evaluate the system strength when SCR>2 or GIR>5.The correctness and rationality of the CSCR and its critical value are validated on ADPSS.
基金Supported by the National Science Foundation of China(11074156)the TYAL,the National Basic Research Program of China(2010CB923101)+1 种基金the NSFC Project for Excellent Research Team(61121064)the Shanxi Scholarship Council of China.
文摘We report a fiber-based four-state discrete modulation continuous variable quantum key distribution system based on homodyne detection.A secret key rate of 1 kbit/s is achieved at a transmission distance of 30.2 km.Two factors that result in the excess noises of the quantum key distribution system are analyzed.The first is the relative phase dithering between the signal and local fields,and the second is the local field leakage into the signal field due to the scattering process that depolarizes the local field.It is found that the latter has a significant impact on the excess noise,which is the main limiting factor to the long-distance secure quantum transmission.Some protocols are also given to decrease the excess noise effectively.
基金supported by the National Natural Science Foundation of China(Grant No.61372076)the Programme of Introducing Talents of Discipline to Universities,China(Grant No.B08038)the Fundamental Research Funds for the Central Universities,China(Grant No.K5051201021)
文摘We construct a circuit based on PBS and CNOT gates, which can be used to determine whether the input pulse is empty or not according to the detection result of the auxiliary state, while the input state will not be changed. The circuit can be treated as a pre-detection device. Equipping the pre-detection device in the front of the receiver of the quantum key distribution （QKD） can reduce the influence of the dark count of the detector, hence increasing the secure communication distance significantly. Simulation results show that the secure communication distance can reach 516 km and 479 km for QKD with perfect single photon source and decoy-state QKD with weak coherent photon source, respectively.
基金Project supported by the Shanghai Jiaotong University (SJTU) Young Teacher Foundation,China (Grant No A2831B)the SJTU Participating in Research Projects (PRPs),China (Grant No T03011030)the National Natural Science Foundation of China(Grant No 60472018)
文摘For the beam splitter attack strategy against quantum key distribution using two-mode squeezed states, the analytical expression of the optimal beam splitter parameter is provided in this paper by applying the Shannon information theory. The theoretical secret information rate after error correction and privacy amplification is given in terms of the squeezed parameter and channel parameters. The results show that the two-mode squeezed state quantum key distribution is secure against an optimal beam splitter attack.
基金the Key Program of the National Natural Science Foundation of China(Grant No.61531003)the National Natural Science Foundation of China(Grant No.62001041)+1 种基金China Postdoctoral Science Foundation(Grant No.2020TQ0016)the Fund of State Key Laboratory of Information Photonics and Optical Communications.
文摘In free space channel,continuous-variable quantum key distribution(CV-QKD)using polarized coherent-states can not only make the signal state more stable and less susceptible to interference based on the polarization non-sensitive of the free-space channel,but also reduce the noise introduced by phase interference.However,arbitrary continuous modulation can not be carried out in the past polarization coding,resulting in that the signal state can not obtain arbitrary continuous value in Poincare space,and the security analysis of CV-QKD using polarized coherent-states in free space is not complete.Here we propose a new modulation method to extend the modulation range of signal states with an optical-fiber-based polarization controller.In particular,in terms of the main influence factors in the free-space channel,we utilize the beam extinction and elliptical model when considering the transmittance and adopt the formulation of secret key rate.In addition,the performance of the proposed scheme under foggy weather is also taken into consideration to reveal the influence of severe weather.Numerical simulation shows that the proposed scheme is seriously affected by attenuation under foggy weather.The protocol fails when visibility is less than 1 km.At the same time,the wavelength can affect the performance of the proposed scheme.Specifically,under foggy weather,the longer the wavelength,the smaller the attenuation coefficient,and the better the transmission performance.Our proposed scheme can expand the modulation range of signal state,and supplement the security research of the scheme in the free-space channel,thus can provide theoretical support for subsequent experiments.
基金Project supported by the National High Technology Development Program of China （Grant Nos 2006AA01Z419 and 2006AA01Z440）, the Major Program of the National Natural Science Foundation of China （Grant No 90604023）, the National Research Foundation for the Doctoral Program of Higher Education of China （Grant No 20040013007）, National Laboratory for Modern Communications Science Foundation of China （Grant No 9140C110101.0.601）.
文摘An efficient quantum key distribution （QKD） protocol with orthogonal product states in the 3 3 Hilbert space is presented. The sender, Alice, disorders the orthogonal product state sequence and sends it to Bob. After Alice has published the matching information of the particle sequence, Bob recovers the correct correspondences and makes an orthogonal measurement on the orthogonal product states to obtain the information sent by Alice. Finally, security analysis is also made.
基金supported by the National Natural Science Foundation of China(Grant No.22075064,52302234,52272241)Zhejiang Provincial Natural Science Foundation of China under Grant No.LR24E020001+2 种基金Natural Science of Heilongjiang Province(No.LH2023B009)China Postdoctoral Science Foundation(2022M710950)Heilongjiang Postdoctoral Fund(LBH-Z21131),National Key Laboratory Projects(No.SYSKT20230056).
文摘To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming alternative.Among the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale applications.However,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their applications.This review provides a comprehensive overview of recent research advancements in OICSEs.Specifically,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically discussed.The lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic perspective.Besides,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of OICSEs.Finally,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.
