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Long-term prognostic role of adiponectin in stable coronary artery disease: A meta-analysis of prospective studies
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作者 Sahas Reddy Jitta Priyanka Vatsavayi +11 位作者 Chenna Reddy Tera Shobana Krishnamurthy Saisree Reddy Adla Jala Diksha Sanjana Pasnoor Utheja Dasari Aisha Farooq Supriya Maramreddy Kavya Jammula Medha Reddy Kesani Sridevi Tripuraneni Nihar Jena Rupak Desai 《World Journal of Cardiology》 2025年第6期153-162,共10页
BACKGROUND The persistent burden of cardiovascular(CV)disease in the United States requires innovative and cost-effective prognostic markers that can be relied upon.AIM To provide insights into how adiponectin can pre... BACKGROUND The persistent burden of cardiovascular(CV)disease in the United States requires innovative and cost-effective prognostic markers that can be relied upon.AIM To provide insights into how adiponectin can predict all-cause mortality and major adverse CV events(MACE)in patients with coronary artery disease(CAD)and to determine the prognostic value of adiponectin in predicting all-cause mortality and MACE in patients with stable CAD.METHODS We conducted a systematic search on PubMed,Scopus,and Google Scholar to find relevant studies published through June 2023 evaluating the long-term prognostic role of adiponectin in patients with stable CAD.Using a random effects model with 95%CI,we estimated the odds ratio(OR)while assessing heterogeneity through I^(2)statistics.To ensure robustness,we performed a sensitivity analysis using the leave-one-out approach.RESULTS After screening,we included five prospective studies involving 3225 patients who were followed up for a median duration of 3.8 years.Within the study population,prevalent risk factors included hypertension,diabetes,hyperlipidemia,and smoking.The commonly prescribed medications were angiotensin-converting enzyme inhibitors,beta blockers,and statins.The combined adjusted OR for all-cause mortality was found to be 2.51(95%CI:1.36–4.62),showing heterogeneity(I^(2)=65.51%,P=0.03).On the other hand,the combined adjusted OR for MACE was determined to be 1.04(95%CI:1.02–1.06)with no significant heterogeneity observed(I^(2)=0%,P=0.68).Through a sensitivity analysis,it was discovered that none of the studies significantly impacted the overall results of the meta-analysis,thus indicating their robustness.CONCLUSION Higher levels of adiponectin were found to be associated with an increased risk of long-term mortality and MACE in patients with CAD,which highlights its potential as a cost-effective marker for risk assessment and guiding treatment strategies.Further research on the role of adiponectin could greatly influence decision-making and resource allocation in CV care. 展开更多
关键词 ADIPONECTIN Stable coronary artery disease Coronary artery disease Major adverse cardiac and cerebrovascular events Mortality LONG-TERM Systematic review META-ANALYSIS
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Well defined phase boundaries and superconductivity with high T_(c)in PbSe single crystal
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作者 Jiawei Hu Yanghao Meng +5 位作者 He Zhang Wei Zhong Hang Zhai Xiaohui Yu Binbin Yue Fang Hong 《Chinese Physics B》 2025年第4期78-84,共7页
Lead chalcogenides represent a significant class of materials that exhibit intriguing physical phenomena,including remarkable thermoelectric properties and superconductivity.In this study,we present a comprehensive in... Lead chalcogenides represent a significant class of materials that exhibit intriguing physical phenomena,including remarkable thermoelectric properties and superconductivity.In this study,we present a comprehensive investigation on the superconductivity of PbSe single crystal under high pressure.The signature of superconducting(SC)transition starts to appear at 7.2 K under 16.5 GPa.Upon further compression,the SC temperature(T_(c))decreases,and it is reduced to 3.5 K at 45.0 GPa.The negative pressure dependent behavior of T_(c)is consistent with the trend of T_(c)-P relations observed in other lead chalcogenides.The highest T_(c)is 8.0 K observed at 20.5 GPa during decompression process,which is also the highest record among all other PbSe derivatives,such as doped samples,superlattices,and so on.The phase boundaries of the structural and electronic transitions are well defined by Raman spectroscopy,and then phase diagrams are plotted for both compression and decompression processes.This work corrects the previous claim of positive pressure dependence of T_(c)in PbSe and provides clear phase diagrams for intrinsic superconductivity in PbSe under pressure. 展开更多
关键词 SUPERCONDUCTIVITY high-pressure electrical transport Raman spectroscopy phase diagrams
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Forward-viewing radial-array echoendoscope for staging of colon cancer beyond the rectum 被引量:5
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作者 Pradermchai Kongkam Sittikorn Linlawan +10 位作者 Satimai Aniwan Narisorn Lakananurak Suparat Khemnark Chucheep Sahakitrungruang Jirawat Pattanaarun Supakij Khomvilai Naruemon Wisedopas Wiriyaporn Ridtitid Manoop S Bhutani Pinit Kullavanijaya Rungsun Rerknimitr 《World Journal of Gastroenterology》 SCIE CAS 2014年第10期2681-2687,共7页
AIM: To evaluate feasibility of the novel forward-viewing radial-array echoendoscope for staging of colon cancer beyond rectum as the first series.
关键词 Colon cancer NEOPLASM Colon Endoscopic ultrasound Neoadjuvan therapy STAGING Forward-viewing COLONOSCOPY
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Elimination of methicillin‑resistant Staphylococcus aureus biofilms on titanium implants via photothermally‑triggered nitric oxide and immunotherapy for enhanced osseointegration
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作者 Yong‑Lin Yu Jun‑Jie Wu +5 位作者 Chuan‑Chuan Lin Xian Qin Franklin R.Tay Li Miao Bai‑Long Tao Yang Jiao 《Military Medical Research》 SCIE CAS CSCD 2024年第2期157-179,共23页
Background:Treatment of methicillin-resistant Staphylococcus aureus(MRSA)biofilm infections in implant placement surgery is limited by the lack of antimicrobial activity of titanium(Ti)implants.There is a need to expl... Background:Treatment of methicillin-resistant Staphylococcus aureus(MRSA)biofilm infections in implant placement surgery is limited by the lack of antimicrobial activity of titanium(Ti)implants.There is a need to explore more effective approaches for the treatment of MRSA biofilm infections.Methods:Herein,an interfacial functionalization strategy is proposed by the integration of mesoporous polydopamine nanoparticles(PDA),nitric oxide(NO)release donor sodium nitroprusside(SNP)and osteogenic growth peptide(OGP)onto Ti implants,denoted as Ti-PDA@SNP-OGP.The physical and chemical properties of Ti-PDA@SNP-OGP were assessed by scanning electron microscopy,X-ray photoelectron spectroscope,water contact angle,photothermal property and NO release behavior.The synergistic antibacterial effect and elimination of the MRSA biofilms were evaluated by 2′,7′-dichlorofluorescein diacetate probe,1-N-phenylnaphthylamine assay,adenosine triphosphate intensity,O-nitrophenyl-β-D-galactopyranoside hydrolysis activity,bicinchoninic acid leakage.Fluorescence staining,assays for alkaline phosphatase activity,collagen secretion and extracellular matrix mineralization,quantitative real‑time reverse transcription‑polymerase chain reaction,and enzyme-linked immunosorbent assay(ELISA)were used to evaluate the inflammatory response and osteogenic ability in bone marrow stromal cells(MSCs),RAW264.7 cells and their co-culture system.Giemsa staining,ELISA,micro-CT,hematoxylin and eosin,Masson's trichrome and immunohistochemistry staining were used to evaluate the eradication of MRSA biofilms,inhibition of inflammatory response,and promotion of osseointegration of Ti-PDA@SNP-OGP in vivo.Results:Ti-PDA@SNP-OGP displayed a synergistic photothermal and NO-dependent antibacterial effect against MRSA following near-infrared light(NIR)irradiation,and effectively eliminated the formed MRSA biofilms by inducing reactive oxygen species(ROS)-mediated oxidative stress,destroying bacterial membrane integrity and causing leakage of intracellular components(P<0.01).In vitro experiments revealed that Ti-PDA@SNP-OGP not only facilitated osteogenic differentiation of MSCs,but also promoted the polarization of pro-inflammatory M1 macrophages to the anti-inflammatory M2-phenotype(P<0.05 or P<0.01).The favorable osteo-immune microenvironment further facilitated osteogenesis of MSCs and the anti-inflammation of RAW264.7 cells via multiple paracrine signaling pathways(P<0.01).In vivo evaluation confirmed the aforementioned results and revealed that Ti-PDA@SNP-OGP induced ameliorative osseointegration in an MRSA-infected femoral defect implantation model(P<0.01).Conclusions:Ti-PDA@SNP-OGP is a promising multi-functional material for the high-efficient treatment of MRSA infections in implant replacement surgeries. 展开更多
关键词 Polydopamine nanoparticles Methicillin-resistant Staphylococcus aureus Nitric oxide OSSEOINTEGRATION Osteo-immunomodulation Photothermal effect Titanium implants
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Assessment of Nutritional Status and Associated Factors in Infants Aged 6 to 23 Months in Rural Burundi
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作者 Michel Baseka Jonathan Niyukuri +3 位作者 Alice Ndayishimiye Sedki Az-Eddine Ferdinand Ndikuryayo Vestine Ntakarutimana 《Food and Nutrition Sciences》 2023年第12期1269-1280,共12页
This study was carried out in the Health districts of Kayanza and Gahombo. Its aim was to assess the nutritional status and associated factors of infants aged between 6 and 23 months. This descriptive and cross-sectio... This study was carried out in the Health districts of Kayanza and Gahombo. Its aim was to assess the nutritional status and associated factors of infants aged between 6 and 23 months. This descriptive and cross-sectional study was carried out in the health centers of the action zone during medical consultations in community medicine from 13 to 22 February 2023. For this purpose, 53.0% of a sample of 398 mothers of infants aged 6 - 23 months were male, and the most represented age group was 12 - 23 months with 53.8%. Mothers were asked about the diet of their children. All the children involved in this study were vaccinated, whereas 99.2% were given vitamin A supplements. The most frequent illnesses in this age group were acute respiratory infection (ARI) (73.4%), fever (66.6%), diarrhea (53.8%), and vomiting (40.5%). Analysis of nutritional status showed that infants had severe (8.3%) and moderate (70.4%) acute malnutrition. Factors associated with infant nutritional status comprised the occupation of mother (P = 0.009), level of education of mother (P = 0.0625), and prolonged diarrhea (P = 0.004). To remedy this problem, concrete nutritional and educational interventions are needed to promote optimal infant nutrition during the first two years of life. 展开更多
关键词 Nutritional Status INFANT Complementary Feeding BURUNDI
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Global Standard Stratotype-Section and Point(GSSP)for the conterminous base of the Miaolingian Series and Wuliuan Stage(Cambrian)at Balang,Jianhe,Guizhou,China 被引量:4
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作者 Yuanlong Zhao Jinliang Yuan +13 位作者 Loren E.Babcock Qingjun Guo Jin Peng Leiming Yin Xinglian Yang Shanchi Peng Chunjiang Wang Robert R.Gaines Jorge Esteve Tongsu Tai Ruidong Yang Yue Wang Haijing Sun Yuning Yang 《Episodes》 2019年第2期165-184,共20页
The International Commission on Stratigraphy and the IUGS Executive Committee have recently ratified a Global Standard Stratotype-section and Point(GSSP)defining the conterminous base of the third series and the fifth... The International Commission on Stratigraphy and the IUGS Executive Committee have recently ratified a Global Standard Stratotype-section and Point(GSSP)defining the conterminous base of the third series and the fifth stage of the Cambrian System.The series and the stage are respectively named the Miaolingian Series and Wuliuan Stage,after the Maioling Mountains in southeastern Guizhou and the Wuliu sidehill,Jianhe County,in eastern Guizhou Province,South China,where the GSSP is located.The GSSP is exposed in a natural outcrop near the Balang Village at a position of 26o44.843'N latitude and 108o24.830'E longitude.It is defined at the base of a silty mudstone layer 52.8 m above the base of the Kaili Formation in the Wuliu-Zengjiayan section,coinciding with the first appearance of the cosmopolitan oryctocephalid trilobite Oryctocephalus indicus(base of the O.indicus Zone).Secondary global markers at or near the base of the series and stage include the peak of a rather large negative carbon isotopic excursion(ROECE excursion),the simultaneous appearance of many acanthomorphic acritarch forms,a transgressive phase of a major eustatic event,and the last appearance of intercontinental polymerid trilobites,either Bathynotus or Ovatoryctocara.Faunal turnovers close to the base of the Miaolingian Series and Wuliuan Stage have been recognized as being at the base of the Oryctocephalus indicus Zone of Amgan Stage in Siberia,the Delamaran Stage in Laurentia,the Oryctocephalus indicus Zone in the Indian Himalaya and North Greenland,near the base of the Delamaran Stage in Australia,and within the Eccaparadocides sdzuyi Zone in Iberia and the Ornamentaspis frequens Zone in Morocco. 展开更多
关键词 miaolingian series Miaolingian series Oryctocephalus indicus zone CAMBRIAN Wuliuan stage Carbon isotopic excursion STRATOTYPE GSSP
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Floristic Diversity and Conservation Status of Guineo-Congolese Species in Southeastern Cameroon: The Case of the Gari-Gombo Communal Forest
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作者 Boris Nyeck Valery Noiha Noumi +3 位作者 Nicole Maffo Maffo Victor Awe Djongmo Cedric Djomo Chimi Louis Zapfack 《Open Journal of Forestry》 2024年第1期87-97,共11页
The conservation of plant biodiversity has become one of the most important objectives in the sustainable management of Guinean-Congolese ecosystems. However, in the south-east zone of Cameroon, there is a lack of rig... The conservation of plant biodiversity has become one of the most important objectives in the sustainable management of Guinean-Congolese ecosystems. However, in the south-east zone of Cameroon, there is a lack of rigor in the management of these forests, which can result in the loss of species of high conservation value. The study was carried out in communal forests in the south-east zone of Cameroon. Its aim was to carry out a floristic inventory and then compare the list of species with the IUCN catalog. Twenty-four plots, each with a surface area of 0.2 ha, were set up in the Gari-Gombo communal forest. All timbers with a DBH ≥ 5 cm were systematically counted. A total of 176 species, belonging to 144 genera and 45 families, were surveyed. Fabaceae (42.08%), Malvaceae (39%), Euphorbiaceae (24.64%), Moraceae (20.92%), Apocynaceae (18.64%), Cecropiaceae (16.60%), Ulmaceae (14.76%), Meliaceae (14.61%), Violaceae (14.08%), Combretaceae (12.67%), Theobroma cacao (21.17%), Baphia leptobotrys (18.06%), Rinorea sp. (14.09%), Musanga cecropioides (12.18%), Terminalia superba (10.32%), Neosloetiopsis kamerunensis (10.14%), Celtis zenkeri (8.29%) and Alstonia boonei (7.77%) were the most important taxa. Nearly 90% of the species in this forest are Guinean species, with a dominance of Guinean-Congolese species (66%). Fourteen (14) threatened species have been identified in the FCGG. This study, which highlights the rich biodiversity of communal forests, is important for guiding biodiversity conservation policies in ecosystems used for production. 展开更多
关键词 Communal Forest Conservation Status Cameroon Floristic Diversity
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EVOKED POTENTIALS OF OBSESSIVE-COMPULSIVE DISORDER:STATE OR TRAIT MARKER
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作者 肖泽萍 陈兴时 +2 位作者 张明岛 楼翡璎 陈珏 《Journal of Shanghai Second Medical University(Foreign Language Edition)》 2004年第2期79-82,共4页
Objective To investigate the status of evoked potentials in obsessive-compulsive disorder(OCD). Methods Evoked potentials P300, auditory brainstem response (ABR) and visual evoked potential ( VEP) were recorded from 3... Objective To investigate the status of evoked potentials in obsessive-compulsive disorder(OCD). Methods Evoked potentials P300, auditory brainstem response (ABR) and visual evoked potential ( VEP) were recorded from 35 OCD patients and 28 normal controls (NC) with a Nicolet Spirit Instrument. 23 of the OCD patients were followed up after 5 months with the same markers. Results Compared with NC, OCD patients showed decreased P3 of P300 amplitude (OCD group 3. 5 ±1. 6μv vs. NC group 5.9 ±2. 1μv, P <0. 01), delayed V latency (6.4±0. 4ms vs. 5. 5 ±0. 3ms, P <0. 01) and increased V amplitude(0. 35±0. 1μv vs. 0. 16 ±0.09μv, P <0. 05) of ABR and delayed P2 of VEP latency (199±39ms vs. 183±28ms, P <0. 05). The follow-up measures of evoked potentials suggested that decreased P3 of P300 amplitude and delayed P2 of VEP latency might be state markers of OCD, while decreased V amplitude and delayed V of ABR latency might be trait markers of OCD. Conclusion The changes of P300 and VEP are related to clinical status of OCD patients, while the association between ABR and OCD symptoms need to be further investigated. 展开更多
关键词 obsessive-compulsive disorder evoked potentials state marker trait marker
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Preceding Crops Selection, Colza Seeding Norms and Dates Optimization in North Kazakhstan
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作者 Gulzhanar Shaihina Abilzhan Husainov +2 位作者 Guldana Seitova Gaziza Kaseinova Aida Mausumbayeva 《Agricultural Sciences》 2014年第14期1407-1412,共6页
Colza is a relatively new crop for North Kazakhstan. The increase of colza seeds production is restricted by its cultivation technology imperfection. Empiric model of colza for seeds cultivation is designed, allowing ... Colza is a relatively new crop for North Kazakhstan. The increase of colza seeds production is restricted by its cultivation technology imperfection. Empiric model of colza for seeds cultivation is designed, allowing using its maximum potential. It was found out that correct preceding crops selection, optimization of norms and dates of colza seeding provide seeds heavy weight crops, reducing crops production cost and increasing cost efficiency at 62% average. 展开更多
关键词 Colza SEEDING DATES SEEDING Norms Preceding CROPS ECONOMIC Efficiency
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Leveraging Fully Digitalized Electronic Invoices to Establish a Model for Driving Digital China
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作者 《Belt and Road Initiative Tax Journal》 2025年第1期5-9,共5页
China is building a model project of digital government with the fully digitalized electronic invoices(FDEls)at the core.Through the"unified national e-invoice service platform",online invoice collection,aut... China is building a model project of digital government with the fully digitalized electronic invoices(FDEls)at the core.Through the"unified national e-invoice service platform",online invoice collection,automatic quota allocation and direct connection with enterprises can be achieved,which can reduce cost,enhance efficiency and promote digital transformation of enterprises.Relying on the precise supervision system of"data+rules,which covers hundreds of millions of trusted identity subjects,the platform can prevent and control risks in real time and align with international standards.The reform has achieved remarkable results:it has covered 95%of enterprises across the country,saved over RMB100 billion in costs annually,and reduced 30 billion paper invoices.Breakthrough innovations,including reconstructing the traditional invoice ecosystem,building the largest information technology innovation cloud platform and digital identity system,and promoting the internationalization of independent tax algorithms,have provided the Chinese solution for"data-driven tax governance"to the world,and contributed to high-quality development andhigh-levelopeningup. 展开更多
关键词 Fully digitalized electronic invoices(FDEls) Tax administration digitalization Smart taxation Tax governance Digital China
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Comprehensive comparison of cellulose nanocrystal (CNC) drying using multi-frequency ultrasonic technology with selected conventional drying technologies 被引量:1
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作者 Junli Liu Amir Malvandi Hao Feng 《Journal of Bioresources and Bioproducts》 EI CSCD 2024年第4期465-485,共21页
Cellulose nanocrystals(CNCs)have garnered increased attention due to their renewable nature,abundant feedstock availbility,and good mechanical properties.However,one of the bottlenecks for its commercial production is... Cellulose nanocrystals(CNCs)have garnered increased attention due to their renewable nature,abundant feedstock availbility,and good mechanical properties.However,one of the bottlenecks for its commercial production is the drying process.Because of the low CNC concentrations in suspension after isolation,CNC drying requires the removal of a large amount of water to obtain dry products for the following utilization and saving shipping costs.A novel multi-frequency,multimode,modulated ultrasonic drying technology was developed for CNC drying to improve product quality,reduce energy consumption,and increase production rate.CNCs dried with dif-ferent drying technologies were characterized by Fourier transform infrared(FT-IR)spectra anal-ysis,X-ray diffraction(XRD)analysis,thermogravimetric analysis(TGA),differential scanning calorimetry(DSC),and redispersibility to measure the quality and property changes.Under the same temperature and airflow rate,ultrasonic drying enhanced drying rates,resulting in at least a 50%reduction in drying time compared to hot air drying.The mean particle sizes of CNC from ultrasonic drying changed little with settling time,indicating good redispersibility.In addition,ultrasonic dried CNCs exhibited good stability in aqueous solutions,with the zeta potentials rang-ing from-35 to-65 mV.Specific energy consumption and CO_(2) emissions of various CNC drying technologies were evaluated.Energy consumption of ultrasonic drying is significantly reduced compared to other drying technologies.Moreover,the potential CO_(2) emissions of the fully elec-trified ultrasonic drying could be net zero if renewable electricity is used. 展开更多
关键词 Cellulose nanocrystals Ultrasound Drying kinetics Drying energy Energy-efficient CO_(2) reduction Redispersibility Carbon sequestration
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DEGENERATE FOUR-WAVE MIXING FOR EXCITING STATES OF MOLECULES
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作者 吴存恺 兰光 《Chinese Science Bulletin》 SCIE EI CAS 1986年第21期1498-1500,共3页
Ⅰ. INTRODUCTION By using degenerate four-wave mixing (DFWM) method, the third-order nonlinear optical susceptibility of transparent media can be conventionally measured. Nonlinear properties of media in ground state ... Ⅰ. INTRODUCTION By using degenerate four-wave mixing (DFWM) method, the third-order nonlinear optical susceptibility of transparent media can be conventionally measured. Nonlinear properties of media in ground state are well known, but those in exciting state are less studied. When a medium absorbs incident radiation, a part of population can be excited into high exciting state. In DFWM this resonant enhancement effect can be used to increase the third- 展开更多
关键词 resonant DEGENERATE EXCITED EXCITING SUSCEPTIBILITY WAVE initially INCIDENT TRANSPARENT mixing
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Magnetic field-induced electronic phase transition in the Dirac semimetal state of black phosphorus under pressure
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作者 Zeliang Sun Ziji Xiang +8 位作者 Zhongyi Wang Jinglei Zhang Long Ma Naizhou Wang Chao Shang Fanbao Meng Liangjian Zou Yuanbo Zhang Xianhui Chen 《Science Bulletin》 SCIE EI CAS CSCD 2018年第23期1539-1544,共6页
Different instabilities have been confirmed to exist in the three-dimensional(3D) electron gas when it is confined to the lowest Landau level in the extreme quantum limit. The recently discovered 3D topological semime... Different instabilities have been confirmed to exist in the three-dimensional(3D) electron gas when it is confined to the lowest Landau level in the extreme quantum limit. The recently discovered 3D topological semimetals offer a good platform to explore these phenomena due to the small sizes of their Fermi pockets, which means the quantum limit can be achieved at relatively low magnetic fields. In this work, we report the high-magnetic-field transport properties of the Dirac semimetal state in pressurized black phosphorus. Under applied hydrostatic pressure, the band structure of black phosphorus goes through an insulator-semimetal transition. In the high pressure topological semimetal phase, anomalous behaviors are observed on both magnetoresistance and Hall resistivity beyond the relatively low quantum limit field, which is demonstrated to indicate the emergence of an exotic electronic state hosting a density wave ordering. Our findings bring the first insight into the electronic interactions in black phosphorus under intense field. 展开更多
关键词 BLACK PHOSPHORUS High magnetic field Quantum LIMIT Electron phase transition
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China's Practice in Improving Tax Environment:An Exclusive Interview with Commissioner Wang Jun of STA,China
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作者 Wang Jun 《Belt and Road Initiative Tax Journal》 2021年第1期3-15,共13页
The United Nations Conference on Trade and Development(UNCTAD)has just released the World Investment Report 2021.According to the report,China remains the world’s second largest recipient of foreign direct investment... The United Nations Conference on Trade and Development(UNCTAD)has just released the World Investment Report 2021.According to the report,China remains the world’s second largest recipient of foreign direct investment(FDI),with its FDI inflows increasing by 6%over the previous year to US$149 billion in 2020,against the backdrop of a significant drop in global FDI inflows due to the COVID-19 epidemic. 展开更多
关键词 service Improving Tax Environment Commissioner
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我国智慧经济的驱动因素研究
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作者 徐铖 《山东商业职业技术学院学报》 2025年第1期6-11,共6页
智慧经济已成为新型经济发展的重要形态,创新集群和技术进步是关键。我国智慧经济发展迅速,但仍面临一些问题。未来我国需优先发展教育、完善金融体系、推广企业家和管理者培训、加强知识产权的控制,出台一揽子政策来支持经济活动的智... 智慧经济已成为新型经济发展的重要形态,创新集群和技术进步是关键。我国智慧经济发展迅速,但仍面临一些问题。未来我国需优先发展教育、完善金融体系、推广企业家和管理者培训、加强知识产权的控制,出台一揽子政策来支持经济活动的智慧化。同时,创新集群的发展对智慧经济发展具有推动作用,政府应重视基础设施投资、企业间合作、培养高技能劳动力、培育创新创业精神以及出台智慧化的配套政策。技术进步在智慧经济发展中也具有重要作用,我国一方面要大力支持技术发展及其与传统产业的融合,打造可持续的创新型智慧经济,另一方面要积极参与国际合作,共同促进智慧经济的发展。 展开更多
关键词 智慧经济 创新集群 技术进步 中国制造2025
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河北滨海盐碱地雨养旱作紫花苜蓿蒸散特性及其影响因子
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作者 张立锋 谢楠 +11 位作者 崔素倩 孙国通 冯伟 石嘉琦 潘璇 智健飞 秦文利 李建明 张洪发 李亚楠 刘振宇 刘忠宽 《草地学报》 北大核心 2025年第2期575-585,共11页
河北省滨海盐碱地土地利用率和产出效益较低,紫花苜蓿(Medicago sativa L.)因其耐盐碱、耐瘠薄的特点,在该地区被广泛种植,种植面积近7万hm^(2)。为研究该地区紫花苜蓿的蒸散特征及环境因子影响,并为其水分管理提供科学依据,本研究利用S... 河北省滨海盐碱地土地利用率和产出效益较低,紫花苜蓿(Medicago sativa L.)因其耐盐碱、耐瘠薄的特点,在该地区被广泛种植,种植面积近7万hm^(2)。为研究该地区紫花苜蓿的蒸散特征及环境因子影响,并为其水分管理提供科学依据,本研究利用Shuttleworth-Wallace模型对国家牧草产业技术体系沧州综合试验站内的紫花苜蓿人工草地蒸散年际变化进行了定量研究。结果显示,2021至2023年间,紫花苜蓿年蒸散量分别为609.9,644.3和678.5 mm,在第二茬和第三茬生长期日均蒸散量最高,而第三茬总蒸散量最大,蒸腾量分别占蒸散量的79.8%,80.6%与80.6%。蒸散与土壤蒸发的变化主要受净辐射、空气温度和叶面积指数的影响,蒸腾则对净辐射、饱和水汽压差和叶面积指数的变化反应敏感。研究表明,该地区降水量基本满足苜蓿生长需求,但在前两茬生长期仍存在水分缺口,因此需加强这一时期的水分管理。 展开更多
关键词 滨海盐碱地 雨养旱作 紫花苜蓿 蒸发 蒸腾 Shuttleworth-Wallace模型
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全球反税基侵蚀规则对我国企业所得税带来的挑战及影响 被引量:2
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作者 岳颂 《税务与经济》 北大核心 2025年第1期15-23,共9页
为应对全球税基侵蚀和利润转移(BEPS)问题,OECD发布的“双支柱”国际税制改革方案应运而生。方案中,支柱二的全球反税基侵蚀规则(GloBE,也称全球最低税规则)由收入纳入规则(IIR)和低税支付规则(UTPR)组成,通过共同方法 (Common Approach... 为应对全球税基侵蚀和利润转移(BEPS)问题,OECD发布的“双支柱”国际税制改革方案应运而生。方案中,支柱二的全球反税基侵蚀规则(GloBE,也称全球最低税规则)由收入纳入规则(IIR)和低税支付规则(UTPR)组成,通过共同方法 (Common Approaches)实施,应税规则要引入税收协定中适用,现在已经正式进入到国内立法的实施阶段。由于GloBE规则的提出可能会弱化我国企业所得税优惠政策效果而使税收饶让条款失效,因此,我国应借鉴部分西方国家实行支柱二全球最低税规则的措施,采取一系列应对方案:选择适用“IIR”并保持阈值门槛;引入“境内最低补足税(QDMTT)”;完善受控外国企业(CFC)的规则;优化我国税收优惠策略;提高税收征管的能力。 展开更多
关键词 全球反税基侵蚀规则 企业所得税 税收竞争 税收饶让
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极大子群的迹和Sylow子群的性质对可解群的影响 被引量:2
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作者 黄潇 张佳 朱丽羽 《吉林大学学报(理学版)》 北大核心 2025年第2期425-427,共3页
结合Sylow子群的可补及交换条件,利用极大子群的迹的超可解性质研究若G的每个极大子群都有超可解的迹,则G是否为可解群的问题,得到了关于可解群的充分必要条件.
关键词 极大子群 SYLOW子群 可解群
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基于转录组测序分析呋虫胺胁迫对家蚕组织解毒酶系与转运蛋白基因表达的影响
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作者 马焕艳 许诗亮 +1 位作者 徐豫松 董久鸣 《蚕业科学》 北大核心 2025年第3期203-214,共12页
为揭示家蚕对呋虫胺(4 mg/L)胁迫的解毒酶系代谢响应及转运蛋白基因表达变化,分析中肠、脂肪体、中部丝腺和后部丝腺的转录组数据,并通过qRT-PCR验证差异表达的解毒酶基因。结果显示,细胞色素P450酶系(cytochrome P450,P450)、羧酸酯酶(... 为揭示家蚕对呋虫胺(4 mg/L)胁迫的解毒酶系代谢响应及转运蛋白基因表达变化,分析中肠、脂肪体、中部丝腺和后部丝腺的转录组数据,并通过qRT-PCR验证差异表达的解毒酶基因。结果显示,细胞色素P450酶系(cytochrome P450,P450)、羧酸酯酶(carboxylesterase,CarE)、谷胱甘肽S-转移酶(glutathione S-transferase,GST)、UDP葡萄糖醛酸转移酶(UDP-glucuronosyltransferase,UGT)等解毒酶相关差异表达基因,以及与解毒代谢相关的转运蛋白ATP结合盒转运蛋白(ATP-binding cassette,ABC)和溶质载体药物转运体(solute carrier,SLC)基因家族的表达在不同组织中有显著差异。P450酶系中,CYP6AN2、CYP4G23、CYP340a1和CYP15C1基因在中肠、脂肪体、中部丝腺和后部丝腺的表达上调,CYP18a1、CYP6AN2和CYP340C1在中肠、中部丝腺和后部丝腺表达下调,脂肪体未见下调基因。CarE基因中,ae19、NOTUM、ie2等在中肠、脂肪体、丝腺的表达上调,Care11、cce3、cce6等基因表达下调。GST基因在中肠、脂肪体和丝腺的主要上调基因为GSTt1、GSTe2和GSTd1,GSTd2、GST1-like、GSTe1等下调。UGT基因在中肠、脂肪体、丝腺的上调基因包括UGT47A1、LOC100862822等,而UGT10288在中肠、中部丝腺和后部丝腺表达下调。ABC基因中,ABCF2、ABCG、ABCD2、ABCF4等基因表达上调,ABCF4、AB-CF1、ABCGBm3、ABCG1等基因表达下调。SLC基因在各组织中的上调基因为SLC2A6、SLCO4A1、SLC12A4等,而下调基因为SLC-17.2、SLC35B1、SLC23A2等。酶活性分析显示,呋虫胺处理后中肠和脂肪体中的P450、CarE、GST和UGT酶活性显著变化(P<0.01),而丝腺中未见显著变化。Western blot结果表明,呋虫胺显著诱导了CYP6AN2和ie2蛋白的上调。总之,家蚕对杀虫剂胁迫的代谢响应在不同组织中具有差异性,解毒酶基因的表达和酶活性受到显著调控。 展开更多
关键词 家蚕 解毒酶 细胞色素P450 羧酸酯酶 UDP葡萄糖醛酸转移酶 ATP结合盒转运蛋白
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单宁酸抗大口黑鲈弹状病毒的作用机制
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作者 玉洁莹 顾屹 +7 位作者 黄琳 王浩 余庆 刘明珠 韩书煜 秦启伟 凌飞 李鹏飞 《南方农业学报》 北大核心 2025年第6期1823-1833,共11页
【目的】从大口黑鲈弹状病毒(MSRV)感染细胞的生命周期探究单宁酸在MSRV感染过程中的潜在作用机制,为研发高效安全的抗MSRV渔用药物提供理论依据。【方法】以胖头鱥肌肉细胞系(FHM)为模型,通过光学显微镜观察、CCK-8检测及免疫荧光染色... 【目的】从大口黑鲈弹状病毒(MSRV)感染细胞的生命周期探究单宁酸在MSRV感染过程中的潜在作用机制,为研发高效安全的抗MSRV渔用药物提供理论依据。【方法】以胖头鱥肌肉细胞系(FHM)为模型,通过光学显微镜观察、CCK-8检测及免疫荧光染色分析单宁酸毒性,确定其安全工作浓度;然后使用结晶紫染色评估单宁酸对MSRV的抑制作用,利用实时荧光定量PCR检测单宁酸体外抗MSRV效果及探析其作用机制,包括单宁酸对MSRV粒子及MSRV吸附宿主细胞表面、侵入细胞与细胞内复制各阶段的影响。【结果】综合光学显微镜观察与CCK-8检测结果,确定单宁酸对FHM细胞的安全工作浓度为0.0125 mg/mL;以0.0125 mg/mL单宁酸孵育36 h后,FHM细胞的骨架结构仍然保持完整,未观察到核膜皱缩或染色质凝聚等异常现象。将0.0125、0.00625和0.003125 mg/mL的单宁酸分别与MSRV共孵育处理,能有效降低MSRV感染FHM细胞产生的病变效应,且FHM细胞中MSRV的N基因相对表达量极显著低于未经单宁酸处理的MSRV感染细胞(P<0.01,下同)。在经单宁酸处理的MSRV感染FHM细胞中,MSRV的N基因相对表达量和病毒滴度均极显著低于未经单宁酸处理的MSRV感染FHM细胞,即单宁酸可直接作用于MSRV粒子,致使其感染能力降低。此外,在MSRV感染的吸附、侵入和复制各阶段以单宁酸进行处理,FHM细胞中MSRV的N基因相对表达量均极显著低于未经单宁酸处理的MSRV感染细胞,即单宁酸通过干扰MSRV感染过程的吸附、侵入与复制而发挥抗病毒作用。【结论】单宁酸对MSRV具有良好的抗病毒作用,可直接作用于MSRV粒子,且对MSRV的吸附、侵入与复制各阶段均有抑制作用,具有开发成高效安全抗MSRV渔用药物的潜力。 展开更多
关键词 大口黑鲈弹状病毒(MSRV) 单宁酸 抗病毒机制 细胞病变效应
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