Primary osteoporosis （POP） is one of the most common diseases in the elderly people resulting in high risk of fracture and poor quality of life. In addition to the pathological changes in bone mass, most of the POP ...Primary osteoporosis （POP） is one of the most common diseases in the elderly people resulting in high risk of fracture and poor quality of life. In addition to the pathological changes in bone mass, most of the POP patients also suffer from Chinese medicine （CM） syndromes of Shen （Kidney） essence deficiency. Shen essences are highly related to bone. Shen essence deficiency plays an important part in the development of POP and a better diagnosis of POP could be made by combining CM syndromes with Western medicine risk factors. Treatments of POP should aim at both increasing the bone mass and relieving the syndromes of Shen essence deficiency. Clinical study confirmed that treating POP patients with Shen-tonifying herbs could increase the bone mass and relieve the CM syndromes of POP patients. Basic researches clarified the mechanism by which Shen-tonifying herbs increased bone mass in animal models. The mechanisms by which Shentonifying herbs relieve the CM syndromes are still in investigation.展开更多
Objective： TO observe the effects of electroacupuncture on force-displacement value （FDV） of muscle state and electrophysiology of the muscle in rabbits with lumbar nerve root compression. Methods： Thirty New Zeal...Objective： TO observe the effects of electroacupuncture on force-displacement value （FDV） of muscle state and electrophysiology of the muscle in rabbits with lumbar nerve root compression. Methods： Thirty New Zealand white rabbits were randomly divided into a control, a model, an electro-acupuncture acupoints （EAA）, a medication, and an electro-acupuncture un-acupoints （EAU） group. All rabbits except those in the control group were subject to modeling （surgical lumbar nerve root compression）. The control group was sham-operated without nerve root compression. The F_AA group received electro-acupuncture at bilateral Shenshu （BL23） and Dachangshu （BL25） that were located 1.5 cun lateral to the posterior midline on the lower border of the spinous process of the 2nd and 4th lumbar vertebra, respectively. The EA was 15 mm deep and the frequency was 2 Hz. Each session lasted for 20 min per day for a total of 14 times. The medication group was treated with Loxoprofen sodium by gastrogavage at 4 mg/kg per day for 14 days. The EAU group received electro-acupuncture identical to the EAA group with regard to the treatment frequency and duration except a different acupoint at the tip of rabbit tail. Muscle states were determined by measuring FDVs of the bilateral biceps femoris using the Myotonometer fast muscle state detector. Meanwhile, the prolonged and non-prolonged insertion potentials were measured by electromyography before and after modeling and after treatment. Latency, amplitude （Amp） of evoked potential, motor nerve conduction velocity （MNCV） were also determined after treatment. Results： （1） After modeling, FDVs of right side activation （RSA, P=0.003） and right side relaxation （RSR） in the model group （P=0.000） were significantly decreased in comparison to the control group. The number of rabbits with non-prolonged insertion potentials in the model group was also significantly decreased （P=0.015） in comparison to the control group. （2） After treatment, FDVs of RSR were significantly increased in the EAA （P=0.000） and medication groups （P=0.018） in comparison to the model group. The increase in FDVs of RSR in the EAA group was significantly higher than that in EAU （P=0.000） and medication groups （P=0.002）. MNCV in the model group was reduced compared with the control group （P-=O.000）. The reduction in MNCV after modeling was reversed in the EAA group （P=0.000） and medication group （P=0.008） after treatment and the increases were significant in both treatment groups in comparison to the model group. The EAA group had a greater MNCV recovery than the medication group （P=0.022）. Conclusion： Electro-acupuncture could improve the rehabilitation and regeneration of FDVs and the electrophysiology index of the muscle with nerve control impairment.展开更多
Objective： To evaluate the renal protective effect of Tangshenkang Granule（糖肾康颗粒） in a rat model of diabetic nephropathy（DN）.Methods： Forty male Sprague-Dawley rats were randomly divided into control,DN,Tan...Objective： To evaluate the renal protective effect of Tangshenkang Granule（糖肾康颗粒） in a rat model of diabetic nephropathy（DN）.Methods： Forty male Sprague-Dawley rats were randomly divided into control,DN,Tangshenkang and benazepril groups.DN model was established in the rats of DN,Tangshenkang and benazepril groups.Tangshenkang Granule solution and benazepril hydrochloride solution were intragastrically administered daily to the rats in the Tangshenkang and benazepril groups for 8 weeks,respectively.Urinary albumin and creatinine were detected.The albumin/creatinine（ACR） was calculated in addition to 24 h urinary protein（24-h UPr）,serum creatinine（Scr）,blood urea nitrogen（BUN）,total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein（LDL）,high-density lipoprotein（HDL）,and creatinine clearance rate（Ccr）.Right kidneys were harvested for pathological observation using periodic acid-silver methenamine-Masson staining.The average glomerular diameter（DG）,average glomerular（AG） and mesangial areas（AM） were measured.The thickness of glomerular basement membrane（TGBM） was detected using transmission electron microscope.Results： Compared with rats in the control group,rats in the DN group showed significantly decreased body weight,increased hypertrophy index,24-h urinary volume,24-h UPr,ACR,Scr,BUN,Ccr,blood lipids as well as renal pathological indices including DG,AG,AM,AM/AG and TGBM（P〈0.05）.Compared with the DN group,the weights of rats in the Tangshenkang and benazepril groups were significantly increased,and the renal hypertrophy indices were significantly decreased（P 〈0.05）.The 24-h urinary volumes,ACR,24-h UPr,Scr,BUN,Ccr,LDL,DG,AG,AM and TGBM were obviously decreased（P 〈0.05）.Compared with the benazepril group,the Tangshenkang group showed significantly decreased levels of ACR,24-h UPr,AG and AM（P 〈0.05）.Conclusion： Tangshenkang Granule decreased the urinary protein,attenuated the high glomerular filtration rate and improved lipid metabolism in DN rats,and prevented further injury induced by diabetic nephropathy.展开更多
Objective:To evaluate the safety and effectiveness of Qishe Pill(芪麝丸)on neck pain in realworld clinical practice.Methods:A multi-center,prospective,observational surveillance in 8 hospitals across Shanghai was cond...Objective:To evaluate the safety and effectiveness of Qishe Pill(芪麝丸)on neck pain in realworld clinical practice.Methods:A multi-center,prospective,observational surveillance in 8 hospitals across Shanghai was conducted.During patients receiving 4-week Qishe Pill medication,Visual Analogue Scale(VAS)and Neck Disability Index(NDI)assessments have been used to assess their pain and function,while safety monitoring have been observed after 2 and 4 weeks.Results:Results from 2,023 patients(mean age 54.5 years)suggest that the drug exposure per unit of body mass was estimated at 3.41±0.62 g/kg.About 8.5%(172/2,023)of all participants experienced adverse events(AEs),while 3.8%(78/2,023)of all participants experienced adverse reaction.The most common AEs were gastrointestinal events and respiratory events.The VAS score(pain)and NDI score(function)significantly decreased after 4-week treatment.An effect-quantitative analysis was also conducted to show that the normal clinical dosage may be consider as 3–4 g/kg,at which dosage the satisfactory pain-relief effect may achieve by 40-mm reduction in VAS.Conclusion:These findings showed that patients with cervical radiculopathy who received Qishe Pill experienced significant improvement on pain and function.(Registration No.NCT01875562).展开更多
基金Supported by the National Basic Research Program of China(973 Program,No.2010CB530400)Program for Innovative Research Team in University(No,IRT1270),National Natural Science Foundation of China(No.81403239)+1 种基金Shanghai Natural Science Foundation(No.12ZR1450400)085 Project of Shanghai University of Traditional Chinese Medicine(No.085ZY1204)
文摘Primary osteoporosis （POP） is one of the most common diseases in the elderly people resulting in high risk of fracture and poor quality of life. In addition to the pathological changes in bone mass, most of the POP patients also suffer from Chinese medicine （CM） syndromes of Shen （Kidney） essence deficiency. Shen essences are highly related to bone. Shen essence deficiency plays an important part in the development of POP and a better diagnosis of POP could be made by combining CM syndromes with Western medicine risk factors. Treatments of POP should aim at both increasing the bone mass and relieving the syndromes of Shen essence deficiency. Clinical study confirmed that treating POP patients with Shen-tonifying herbs could increase the bone mass and relieve the CM syndromes of POP patients. Basic researches clarified the mechanism by which Shen-tonifying herbs increased bone mass in animal models. The mechanisms by which Shentonifying herbs relieve the CM syndromes are still in investigation.
文摘Objective： TO observe the effects of electroacupuncture on force-displacement value （FDV） of muscle state and electrophysiology of the muscle in rabbits with lumbar nerve root compression. Methods： Thirty New Zealand white rabbits were randomly divided into a control, a model, an electro-acupuncture acupoints （EAA）, a medication, and an electro-acupuncture un-acupoints （EAU） group. All rabbits except those in the control group were subject to modeling （surgical lumbar nerve root compression）. The control group was sham-operated without nerve root compression. The F_AA group received electro-acupuncture at bilateral Shenshu （BL23） and Dachangshu （BL25） that were located 1.5 cun lateral to the posterior midline on the lower border of the spinous process of the 2nd and 4th lumbar vertebra, respectively. The EA was 15 mm deep and the frequency was 2 Hz. Each session lasted for 20 min per day for a total of 14 times. The medication group was treated with Loxoprofen sodium by gastrogavage at 4 mg/kg per day for 14 days. The EAU group received electro-acupuncture identical to the EAA group with regard to the treatment frequency and duration except a different acupoint at the tip of rabbit tail. Muscle states were determined by measuring FDVs of the bilateral biceps femoris using the Myotonometer fast muscle state detector. Meanwhile, the prolonged and non-prolonged insertion potentials were measured by electromyography before and after modeling and after treatment. Latency, amplitude （Amp） of evoked potential, motor nerve conduction velocity （MNCV） were also determined after treatment. Results： （1） After modeling, FDVs of right side activation （RSA, P=0.003） and right side relaxation （RSR） in the model group （P=0.000） were significantly decreased in comparison to the control group. The number of rabbits with non-prolonged insertion potentials in the model group was also significantly decreased （P=0.015） in comparison to the control group. （2） After treatment, FDVs of RSR were significantly increased in the EAA （P=0.000） and medication groups （P=0.018） in comparison to the model group. The increase in FDVs of RSR in the EAA group was significantly higher than that in EAU （P=0.000） and medication groups （P=0.002）. MNCV in the model group was reduced compared with the control group （P-=O.000）. The reduction in MNCV after modeling was reversed in the EAA group （P=0.000） and medication group （P=0.008） after treatment and the increases were significant in both treatment groups in comparison to the model group. The EAA group had a greater MNCV recovery than the medication group （P=0.022）. Conclusion： Electro-acupuncture could improve the rehabilitation and regeneration of FDVs and the electrophysiology index of the muscle with nerve control impairment.
基金Supported by the Scientific Research Project of Colleges and Universities in Anhui Province,China(No.2013z172)the National Natural Science Foundation of China(No.81503590)
文摘Objective： To evaluate the renal protective effect of Tangshenkang Granule（糖肾康颗粒） in a rat model of diabetic nephropathy（DN）.Methods： Forty male Sprague-Dawley rats were randomly divided into control,DN,Tangshenkang and benazepril groups.DN model was established in the rats of DN,Tangshenkang and benazepril groups.Tangshenkang Granule solution and benazepril hydrochloride solution were intragastrically administered daily to the rats in the Tangshenkang and benazepril groups for 8 weeks,respectively.Urinary albumin and creatinine were detected.The albumin/creatinine（ACR） was calculated in addition to 24 h urinary protein（24-h UPr）,serum creatinine（Scr）,blood urea nitrogen（BUN）,total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein（LDL）,high-density lipoprotein（HDL）,and creatinine clearance rate（Ccr）.Right kidneys were harvested for pathological observation using periodic acid-silver methenamine-Masson staining.The average glomerular diameter（DG）,average glomerular（AG） and mesangial areas（AM） were measured.The thickness of glomerular basement membrane（TGBM） was detected using transmission electron microscope.Results： Compared with rats in the control group,rats in the DN group showed significantly decreased body weight,increased hypertrophy index,24-h urinary volume,24-h UPr,ACR,Scr,BUN,Ccr,blood lipids as well as renal pathological indices including DG,AG,AM,AM/AG and TGBM（P〈0.05）.Compared with the DN group,the weights of rats in the Tangshenkang and benazepril groups were significantly increased,and the renal hypertrophy indices were significantly decreased（P 〈0.05）.The 24-h urinary volumes,ACR,24-h UPr,Scr,BUN,Ccr,LDL,DG,AG,AM and TGBM were obviously decreased（P 〈0.05）.Compared with the benazepril group,the Tangshenkang group showed significantly decreased levels of ACR,24-h UPr,AG and AM（P 〈0.05）.Conclusion： Tangshenkang Granule decreased the urinary protein,attenuated the high glomerular filtration rate and improved lipid metabolism in DN rats,and prevented further injury induced by diabetic nephropathy.
基金Supported by the National Science Fundation for Young Scholars of China(No.81804115,No.81873317,No.81930116 and No.82074454)the State Key Program of National Natural Science of China(No.81330085 and No.81930116)+3 种基金Shanghai Sailing Program(No.18YF1423800)Shanghai TCM Medical Center of Chronic Disease(No.2017ZZ01010)Municipal Science and Technology Commission of Shanghai-TCM Key Project(No.16401970100)National Thirteenth Five-Year Science and Technology Major Special Project for New Drug Innovation and Development(No.2017ZX09304001)。
文摘Objective:To evaluate the safety and effectiveness of Qishe Pill(芪麝丸)on neck pain in realworld clinical practice.Methods:A multi-center,prospective,observational surveillance in 8 hospitals across Shanghai was conducted.During patients receiving 4-week Qishe Pill medication,Visual Analogue Scale(VAS)and Neck Disability Index(NDI)assessments have been used to assess their pain and function,while safety monitoring have been observed after 2 and 4 weeks.Results:Results from 2,023 patients(mean age 54.5 years)suggest that the drug exposure per unit of body mass was estimated at 3.41±0.62 g/kg.About 8.5%(172/2,023)of all participants experienced adverse events(AEs),while 3.8%(78/2,023)of all participants experienced adverse reaction.The most common AEs were gastrointestinal events and respiratory events.The VAS score(pain)and NDI score(function)significantly decreased after 4-week treatment.An effect-quantitative analysis was also conducted to show that the normal clinical dosage may be consider as 3–4 g/kg,at which dosage the satisfactory pain-relief effect may achieve by 40-mm reduction in VAS.Conclusion:These findings showed that patients with cervical radiculopathy who received Qishe Pill experienced significant improvement on pain and function.(Registration No.NCT01875562).
