Precodings using square-root decomposition,including Cholesky and G-To-Minus-Half(GTMH)precodings,are promising for eliminating the Faster-Than-Nyquist(FTN)-induced Intersymbol-Interference(ISI).However,the existing p...Precodings using square-root decomposition,including Cholesky and G-To-Minus-Half(GTMH)precodings,are promising for eliminating the Faster-Than-Nyquist(FTN)-induced Intersymbol-Interference(ISI).However,the existing precodings using square-root decomposition either ignore Interblock-Interference(IBI)or increase the signal power,deteriorating the Bit Error Rate(BER)performance for high-order modulations and severe ISI.To overcome these drawbacks,we adopt two approaches for constructing the circular ISI matrix.The first approach inserts a Cyclic Prefix/Suffix(CPS)after each precoded symbol block,while the second approach replaces the linear convolution of the FTN shaping and the matched filter by the circular convolution,resulting in the Circular FTN(CFTN).Using these two approaches,we propose three IBI-free precodings,i.e.,CPS-Cholesky,CFTN-Cholesky and CFTN-GTMH precodings.Furthermore,employing QR decomposition shows that the GTMH and Cholesky precodings can be converted interchangeably.Thus,we demonstrate that the GTMH precoding is essentially equivalent to the Cholesky precoding.Simulation results indicate that the BER performance of three IBI-free precodings approaches Nyquist performance for moderate ISI.However,as ISI intensifies,the CPS-Cholesky scheme increases the transmit power,causing BER performance degradation.In contrast,the CFTN-Cholesky and CFTN-GTMH precodings maintain optimal BER performance even for severe ISI.Considering 128-amplitude phase shift keying with a code rate of 1/2,the BER loss of CFTN-Cholesky and CFTN-GTMH precodings for the ideal BER of 10-5 is approximately 0.002 dB and 0.005 dB when packing factor is 0.7 and roll-offfactor is 0.3.To the best knowledge of the authors,this is the optimal performance achievable through precoding.展开更多
This paper presents an approach of singular value de- composition plus digital phase lock loop to solve the difficult problem of blind pseudo-noise （PN） sequence estimation in low signal to noise ratios （SNR） dire...This paper presents an approach of singular value de- composition plus digital phase lock loop to solve the difficult problem of blind pseudo-noise （PN） sequence estimation in low signal to noise ratios （SNR） direct sequence spread spectrum （DS-SS） signals with residual carrier. This approach needs some given parameters, such as the period and code rate of PN sequence. The received signal is firstly sampled and divided into non-overlapping signal vectors according to a temporal window, whose duration is two periods of PN sequence. An autocorrelation matrix is then computed and accumulated by those signal vectors one by one. The PN sequence with residual carrier can be estimated by the principal eigenvector of the autocorrelation matrix. Further more, a digital phase lock loop is used to process the estimated PN sequence, it estimates and tracks the residual carrier and removes the residual carrier in the end. Theory analysis and computer simulation results show that this approach can effectively realize the PN sequence blind estimation from the input DS-SS signals with residual carrier in lower SNR.展开更多
This letter delnonstrates the structure of the passive radar using TV signals. Because the TV signal is a kind of pseudoperiodic signal, the matched filtering of color TV signals would yield high sidelobes which cause...This letter delnonstrates the structure of the passive radar using TV signals. Because the TV signal is a kind of pseudoperiodic signal, the matched filtering of color TV signals would yield high sidelobes which cause the range ambiguity. To overcome this problem, the mismatched filter is proposed to suppress the correlation sidelobcs of matched filtering of TV signals. By utilizing the iteration process, this method could achieve the required peak sidclobc level. The impacts of the noise and target movement on mismatched filtering are also analysed, Simulation results are included to demonstrate the effectiveness of the proposed technique.展开更多
The Wnt/β-catenin signaling pathway regulates many aspects of tumor biology,and many studies have focused on the role of this signaling pathway in tumor cells.However,it is now clear that tumor development and metast...The Wnt/β-catenin signaling pathway regulates many aspects of tumor biology,and many studies have focused on the role of this signaling pathway in tumor cells.However,it is now clear that tumor development and metastasis depend on the two-way interaction between cancer cells and their environment,thereby forming a tumor microenvironment(TME).In this review,we discuss how Wnt/β-catenin signaling regulates cross-interactions among different components of the TME,including immune cells,stem cells,tumor vasculature,and noncellular components of the TME in hepatocellular carcinoma.We also investigate their preclinical and clinical insights for primary liver cancer intervention,and explore the significance of using Wnt/β-catenin mutations as a biomarker to predict resistance in immunotherapy.展开更多
Vehicle delay is an important measure to evaluate the signal timings of signalized intersections.When optimization the signal control parameters, delays of vehicles from all approach directions of an intersection shou...Vehicle delay is an important measure to evaluate the signal timings of signalized intersections.When optimization the signal control parameters, delays of vehicles from all approach directions of an intersection should be considered. Based on the analysis of the vehicle delay on an approach of intersection, directed against the typical condition of a congested intersection-over-saturated condition, the paper has analyzed and inferred the intersection delay dynamic formulation, and has established the relation between intersection delay,the signal timings, vehicle arrival rate and the queue lengths, and that provides useful information for understanding vehicle delay of signalized intersection and for establishing performance index function of signal timing optimization.展开更多
A method for estimating current harmonics of an induction motor is introduced which is used for sensorless monitoring of a mechanical system driven by the motor. The method is based on an adaptive signal representatio...A method for estimating current harmonics of an induction motor is introduced which is used for sensorless monitoring of a mechanical system driven by the motor. The method is based on an adaptive signal representation and is proposed to extract weak harmonics from a noisy current signal, especially in the presence of additive interference caused by transient modulation waves. As an application, a rotor unbalance experiment of rotating machinery driven by an induction motor is carried out, The result shows that the eccentricity harmonic magnitude of a current signal obtained by the method represents the rotor unbalance conditions sensitively. Vibration analysis is used to validate the proposed method.展开更多
Smads are critical intracellular signal transducers for transforming growth factor-β(TGF-β) in mammalian cells. In this study, we have identified WD repeat-containing protein 74(WDR74) as a novel transcriptional coa...Smads are critical intracellular signal transducers for transforming growth factor-β(TGF-β) in mammalian cells. In this study, we have identified WD repeat-containing protein 74(WDR74) as a novel transcriptional coactivator for Smads in the canonical TGF-β signaling pathway. Through direct interactions with Smad proteins, WDR74 enhances TGF-β-mediated phosphorylation and nuclear accumulation of Smad2 and Smad3. Consequently, WDR74 enables stronger transcriptional responses and more robust TGF-β-induced physiological responses. Our findings have elucidated a critical role of WDR74 in regulating TGF-β signaling.展开更多
With the support of Vehicle-to-Everything(V2X)technology and computing power networks,the existing intersection traffic order is expected to benefit from efficiency improvements and energy savings by new schemes such ...With the support of Vehicle-to-Everything(V2X)technology and computing power networks,the existing intersection traffic order is expected to benefit from efficiency improvements and energy savings by new schemes such as de-signalization.How to effectively manage autonomous vehicles for traffic control with high throughput at unsignalized intersections while ensuring safety has been a research hotspot.This paper proposes a collision-free autonomous vehicle scheduling framework based on edge-cloud computing power networks for unsignalized intersections where the lanes entering the intersections are undirectional,and designs an efficient communication system and protocol.First,by analyzing the collision point occupation time,this paper formulates an absolute value programming problem.Second,this problem is solved with low complexity by the Edge Intelligence Optimal Entry Time(EI-OET)algorithm based on edge-cloud computing power support.Then,the communication system and protocol are designed for the proposed scheduling scheme to realize efficient and low-latency vehicular communications.Finally,simulation experiments compare the proposed scheduling framework with directional and traditional traffic light scheduling mechanisms,and the experimental results demonstrate its high efficiency,low latency,and low complexity.展开更多
In order to reduce the magnetically electromotive force of railway signal cables, combined with the basic engineering conditions for setting the interval grounding round steel, it is recommended to ground the signal c...In order to reduce the magnetically electromotive force of railway signal cables, combined with the basic engineering conditions for setting the interval grounding round steel, it is recommended to ground the signal cables at both ends. It is necessary to further increase the grounding measures to reduce the value of the magnetically induced electromotive force when the distance is km. At the same time, the signal cable should be installed as far away from the catenary as possible in the engineering design stage. For this reason, when the train is running in the shield tunnel, the protection of the signal cable also puts forward an objective requirement that is different from the DC power supply project. This paper investigates this.展开更多
A key issue to be addressed in stem cell biology is the molecular signaling mechanism controlling embryonic stem （ES） cell pluripotency. Stem cell properties are dictated by specific transcription factors and epigen...A key issue to be addressed in stem cell biology is the molecular signaling mechanism controlling embryonic stem （ES） cell pluripotency. Stem cell properties are dictated by specific transcription factors and epigenetic processes such as DNA methylation and chromatin remodeling. Several cytokines/growth factors have been identified as critical ES cell regulators. However, there is a gap in our knowledge of the intracellular signaling pathways linking extracellular signals to transcriptional regulation in ES cells. This short review discusses the physiological role of Shp2, a cytoplasmic tyro- sine phosphatase, in the molecular switch governing ES cell self-renewal versus differentiation. Shp2 promotes ES cell differentiation, mainly through bi-directional modulation of Erk and Stat3 pathways. Deletion of Shp2 in mouse ES cells results in more efficient self-renewal. This observation provides the impetus to develop Shp2 inhibitors for maintenance and amplification of ES cells in culture.展开更多
Stochastic resonance system is an effective method to extract weak signal.However,system output is directly influenced by system parameters.Aiming at this,the Levy noise is combined with a tri-stable stochastic resona...Stochastic resonance system is an effective method to extract weak signal.However,system output is directly influenced by system parameters.Aiming at this,the Levy noise is combined with a tri-stable stochastic resonance system.The average signal-to-noise ratio gain is regarded as an index to measure the stochastic resonance phenomenon.The characteristics of tri-stable stochastic resonance under Levy noise is analyzed in depth.First,the method of generating Levy noise,the effect of tri-stable system parameters on the potential function and corresponding potential force are presented in detail.Then,the effects of tri-stable system parameters w,a,b,and Levy noise intensity amplification factor D on the resonant output can be explored with different Levy noises.Finally,the tri-stable stochastic resonance system is applied to the bearing fault detection.Simulation results show that the stochastic resonance phenomenon can be induced by tuning the system parameters w,a,and b under different distributions of Levy noise,then the weak signal can be detected.The parameter intervals which can induce stochastic resonances are approximately equal.Moreover,by adjusting the intensity amplification factor D of Levy noise,the stochastic resonances can happen similarly.In bearing fault detection,the detection effect of the tri-stable stochastic resonance system is superior to the bistable stochastic resonance system.展开更多
The prevalence of cardiovascular diseases(CVDs)is increasing at a rapid pace in developed countries,and CVDs are the leading cause of morbidity and mortality.Natural products and ethnomedicine have been shown to reduc...The prevalence of cardiovascular diseases(CVDs)is increasing at a rapid pace in developed countries,and CVDs are the leading cause of morbidity and mortality.Natural products and ethnomedicine have been shown to reduce the risk of CVDs.Schizonepeta(S.)tenuifolia is a medicinal plant widely used in China,Korea,and Japan and is known to exhibit anti-inflammatory,antioxidant,and immunomodulatory activities.We hypothesized that given herbal plant exhibit pharmacological activities against CVDs,we specifically explored its effects on platelet function.Platelet aggregation was evaluated using standard light transmission aggregometry.Intracellular calcium mobilization was assessed using Fura-2/AM,and granule secretion(ATP release)was measured in a luminometer.Fibrinogen binding to integrin a_(Ⅱb)β_3,was assessed using flow cytometry.Phosphorylation of mitogen-activated protein kinase(MAPK)signaling molecules and activation of the protein kinase B(Akt)was assessed using Western blot assays.S.tenuifolia,extract potently and significantly inhibited platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin a_(Ⅱb)β_3.Moreover,all extracts significantly inhibited MAPK and Akt phosphorylation.S.tenuifolia extract inhibited platelet aggregation and granule secretion,and attenuated collagen mediated GPVI downstream signaling,indicating the potential therapeutic effects of these plant extracts on the cardiovascular system and platelet function.We suggest that S.tenuifolia extract may be a potent candidate to treat platelet-related CVDs and to be used as an antiplatelet and antithrombotic agent.展开更多
Frequency diverse array(FDA)radar has been studied for more than 15 years and has attracted a lot of attention due to its potential advantages over the well-known phased array radar.The representative feature of FDA i...Frequency diverse array(FDA)radar has been studied for more than 15 years and has attracted a lot of attention due to its potential advantages over the well-known phased array radar.The representative feature of FDA is range-angle-time-dependent transmit beampattern and its underlying properties are continuously revealed in the research.The formulation and exploitation of the transmit diversity with a frequency increment is the fundamental principle,which brings extra degrees-of-freedom(DOFs)in the transmit dimension.As the FDA radar carries additional information in range,it provides more flexibility in signal processing and also brings in new technical issues.This article overviews the state-of-the-art in FDA radar area and its applications,mainly based on the progress in our group.There are two main catalogs in FDA radar area,namely coherent FDA and FDA-MIMO(multiple-input multiple-output)radars.Potential applications including target parameter estimation,ambiguous clutter suppression,and deceptive jammer suppression are discussed.展开更多
In order to solve the problem of coherent signal subspace method(CSSM) depending on the estimated accuracy of signal subspace, a new direction of arrival(DOA) estimation method of wideband source, which is based on it...In order to solve the problem of coherent signal subspace method(CSSM) depending on the estimated accuracy of signal subspace, a new direction of arrival(DOA) estimation method of wideband source, which is based on iterative adaptive spectral reconstruction, is proposed. Firstly, the wideband signals are divided into several narrowband signals of different frequency bins by discrete Fourier transformation(DFT). Then, the signal matched power spectrum in referenced frequency bins is computed, which can form the initial covariance matrix. Finally, the linear restrained minimum variance spectral(Capon spectral) of signals in other frequency bins are reconstructed using sequential iterative means, so the DOA can be estimated by the locations of spectral peaks. Theoretical analysis and simulation results show the proposed method based on the iterative spectral reconstruction for the covariance matrices of all sub-bands can avoid the problem of determining the signal subspace accurately with the coherent signal subspace method under the conditions of small samples and low signal to noise ratio(SNR), and it can also realize full dimensional focusing of different sub-band data, which can be applied to coherent sources and can significantly improve the accuracy of DOA estimation.展开更多
Background: Hepatocellular carcinoma(HCC) is one of the most highly malignant tumors. Liver tumor-initiating cells(LTICs) have been considered to contribute to HCC progression and metastasis. ATP-citrate lyase(ACLY), ...Background: Hepatocellular carcinoma(HCC) is one of the most highly malignant tumors. Liver tumor-initiating cells(LTICs) have been considered to contribute to HCC progression and metastasis. ATP-citrate lyase(ACLY), as a key enzyme for de novo lipogenesis, has been reported to be upregulated in various tumors. However, its expression and role in HCC and LTICs remain unknown. Methods: The expressions of ACLY in HCC tissues were detected by quantitative real-time PCR(q RT-PCR), Western blotting and immunohistochemistry. Kaplan-Meier curves and Chi-square test were used to determine the clinical significance of ACLY expression in HCC patients. A series of assays were performed to determine the function of ACLY on stemness, migration and invasion of HCC cells. Luciferase reporter assay, Western blotting and immunoprecipitation were used to study the regulation of the Wnt/β-catenin signaling by ACLY. Rescue experiments were performed to investigate whether β-catenin was the mediator of ACLY-regulated stemness and migration in HCC cells. Results: ACLY was highly expressed in HCC tissues and LTICs. Overexpression of ACLY was significantly correlated with poor prognosis, progression and metastasis of HCC patients. Knockdown of ACLY remarkably suppressed stemness properties, migration and invasion in HCC cells. Mechanistically, ACLY could regulate the canonical Wnt pathway by affecting the stability of β-catenin, and Lys49 acetylation of β-catenin might mediate ACLY-regulated β-catenin level in HCC cells. Conclusions: ACLY is a potent regulator of Wnt/β-catenin signaling in modulating LTICs stemness and metastasis in HCC. ACLY may serve as a new target for the diagnosis and treatment of HCC.展开更多
Link16 data link is the communication standard of the joint tactical information distribution system(JTIDS)used by the U.S.military and North Atlantic Treaty Organization,which is applied as the opportunistic illumina...Link16 data link is the communication standard of the joint tactical information distribution system(JTIDS)used by the U.S.military and North Atlantic Treaty Organization,which is applied as the opportunistic illuminator for passive radar in this paper.The time-domain expression of the Link16 signal is established,and its ambiguity function expression is derived.The timedelay dimension and Doppler dimension side peaks of which lead to the appearance of the false target during target detection.To solve the problem,the time-delay dimension and Doppler dimension side peaks suppression methods are proposed.For the problem that the conventional mismatched filter(MMF)cannot suppress the time-delay dimension side peaks,a neighborhood MMF(NMMF)is proposed.Experimental results demonstrate the effectiveness of the proposed methods.展开更多
Many animals can detect the multi-frequency signals from their external surroundings.The understanding for underlying mechanism of signal detection can apply the theory of vibrational resonance,in which the moderate h...Many animals can detect the multi-frequency signals from their external surroundings.The understanding for underlying mechanism of signal detection can apply the theory of vibrational resonance,in which the moderate high frequency driving can maximize the nonlinear system's response to the low frequency subthreshold signal.In this work,we study the roles of chemical autapse on the vibrational resonance in a single neuron for signal detection.We reveal that the vibrational resonance is strengthened significantly by the inhibitory autapse in the neuron,while it is weakened typically by the excitatory autapse.It is generally believed that the inhibitory synapse has a suppressive effect in neuronal dynamics.However,we find that the detection of the neuron to the low frequency subthreshold signal can be improved greatly by the inhibitory autapse.Our finding indicates that the inhibitory synapse may act constructively on the detection of weak signal in the brain and neuronal system.展开更多
The hybrid waveform of linear frequency modulation and binary phase shift keying(LFM-BPSK)can take advantages of the LFM and BPSK signals,and reduce the defects of them.However,with the development of interception tec...The hybrid waveform of linear frequency modulation and binary phase shift keying(LFM-BPSK)can take advantages of the LFM and BPSK signals,and reduce the defects of them.However,with the development of interception technology for the LFM-BPSK signal,the application of the signal is limited.In this paper,to improve the anti-interception performance of the hybrid waveform,a new waveform of LFM-BPSK with the varying chirp rate(denoted as VCR-LFM-BPSK)is designed.In this design,based on the working principle of the interception frame for the LFM-BPSK signal,different chirp rates are introduced in different sub-pulses to prevent the signal from being intercepted by the frame.Then,to further improve the anti-interception performance of the VCR-LFM-BPSK signal,the chirp rates are optimized by minimizing the interception capability of the interceptor.Moreover,based on the VCR-LFM-BPSK signal with the optimized chirp rates,the binary phases are designed via a multiobjective Pareto optimization to improve the capabilities of autocorrelation and spectrum.Simulation results demonstrate that the designed VCR-LFM-BPSK signal outperforms the traditional LFM-BPSK signal in countering the advanced interception technologies.展开更多
The location of a moving target based on signal fitting and sub-aperture tracking from an airborne multi-channel radar is dealt with.The proposed approach is applied in two steps：first,the ambiguous slant-range veloc...The location of a moving target based on signal fitting and sub-aperture tracking from an airborne multi-channel radar is dealt with.The proposed approach is applied in two steps：first,the ambiguous slant-range velocity is derived with a modified single-snapshot multiple direction of arrival estimation method,and second,the unambiguous slant-range velocity is found using a track-based criterion.The prominent advantage of the proposed approach is that the unambiguous slant-range velocity can be very large.Besides,the first stage is carried out at the determinate range-Doppler test cell by azimuth searching for fitting best to the moving target signal,therefore,the location performance would not be sacrificed in order to suppress clutter and/or interference.The effectiveness and efficiency of the proposed method are validated with a set of airborne experimental data.展开更多
基金supported in part by National Natural Science Foundation of China under Grants 62071002 and 62471004in part by"Double First-Class"Discipline Creation Project of Surveying Science and Technology under Grants CHXKYXBS03 and GCCRC202306+1 种基金in part by Anhui Provincial Natural Science Foundation under Grant 2408085QF207in part by Anhui Provincial University Distinguished Research and Innovation Team Foundation under Grant 2024AH010003.
文摘Precodings using square-root decomposition,including Cholesky and G-To-Minus-Half(GTMH)precodings,are promising for eliminating the Faster-Than-Nyquist(FTN)-induced Intersymbol-Interference(ISI).However,the existing precodings using square-root decomposition either ignore Interblock-Interference(IBI)or increase the signal power,deteriorating the Bit Error Rate(BER)performance for high-order modulations and severe ISI.To overcome these drawbacks,we adopt two approaches for constructing the circular ISI matrix.The first approach inserts a Cyclic Prefix/Suffix(CPS)after each precoded symbol block,while the second approach replaces the linear convolution of the FTN shaping and the matched filter by the circular convolution,resulting in the Circular FTN(CFTN).Using these two approaches,we propose three IBI-free precodings,i.e.,CPS-Cholesky,CFTN-Cholesky and CFTN-GTMH precodings.Furthermore,employing QR decomposition shows that the GTMH and Cholesky precodings can be converted interchangeably.Thus,we demonstrate that the GTMH precoding is essentially equivalent to the Cholesky precoding.Simulation results indicate that the BER performance of three IBI-free precodings approaches Nyquist performance for moderate ISI.However,as ISI intensifies,the CPS-Cholesky scheme increases the transmit power,causing BER performance degradation.In contrast,the CFTN-Cholesky and CFTN-GTMH precodings maintain optimal BER performance even for severe ISI.Considering 128-amplitude phase shift keying with a code rate of 1/2,the BER loss of CFTN-Cholesky and CFTN-GTMH precodings for the ideal BER of 10-5 is approximately 0.002 dB and 0.005 dB when packing factor is 0.7 and roll-offfactor is 0.3.To the best knowledge of the authors,this is the optimal performance achievable through precoding.
基金supported by the National Natural Science Foundation of China (10776040 60602057)+4 种基金Program for New Century Excellent Talents in University (NCET)the Project of Key Laboratory of Signal and Information Processing of Chongqing (CSTC2009CA2003)the Natural Science Foundation of Chongqing Science and Technology Commission (CSTC2009BB2287)the Natural Science Foundation of Chongqing Municipal Education Commission (KJ060509 KJ080517)
文摘This paper presents an approach of singular value de- composition plus digital phase lock loop to solve the difficult problem of blind pseudo-noise （PN） sequence estimation in low signal to noise ratios （SNR） direct sequence spread spectrum （DS-SS） signals with residual carrier. This approach needs some given parameters, such as the period and code rate of PN sequence. The received signal is firstly sampled and divided into non-overlapping signal vectors according to a temporal window, whose duration is two periods of PN sequence. An autocorrelation matrix is then computed and accumulated by those signal vectors one by one. The PN sequence with residual carrier can be estimated by the principal eigenvector of the autocorrelation matrix. Further more, a digital phase lock loop is used to process the estimated PN sequence, it estimates and tracks the residual carrier and removes the residual carrier in the end. Theory analysis and computer simulation results show that this approach can effectively realize the PN sequence blind estimation from the input DS-SS signals with residual carrier in lower SNR.
文摘This letter delnonstrates the structure of the passive radar using TV signals. Because the TV signal is a kind of pseudoperiodic signal, the matched filtering of color TV signals would yield high sidelobes which cause the range ambiguity. To overcome this problem, the mismatched filter is proposed to suppress the correlation sidelobcs of matched filtering of TV signals. By utilizing the iteration process, this method could achieve the required peak sidclobc level. The impacts of the noise and target movement on mismatched filtering are also analysed, Simulation results are included to demonstrate the effectiveness of the proposed technique.
基金supported by the National Research Program of China(Grant Nos.2017YFA0505803 and 2017YFC0908100)the State Key Project for Infectious Diseases(Grant Nos.2018ZX10732202-001 and 2018ZX10302207-004)the National Natural Science Foundation of China(Grant Nos.81790633,61922047,and 81902412).
文摘The Wnt/β-catenin signaling pathway regulates many aspects of tumor biology,and many studies have focused on the role of this signaling pathway in tumor cells.However,it is now clear that tumor development and metastasis depend on the two-way interaction between cancer cells and their environment,thereby forming a tumor microenvironment(TME).In this review,we discuss how Wnt/β-catenin signaling regulates cross-interactions among different components of the TME,including immune cells,stem cells,tumor vasculature,and noncellular components of the TME in hepatocellular carcinoma.We also investigate their preclinical and clinical insights for primary liver cancer intervention,and explore the significance of using Wnt/β-catenin mutations as a biomarker to predict resistance in immunotherapy.
基金Sponsored by the Mulfidiscipline Scientific Research Foundation of Harbin Institute of Technology( Grant No. HIT. MD. 2002.28)
文摘Vehicle delay is an important measure to evaluate the signal timings of signalized intersections.When optimization the signal control parameters, delays of vehicles from all approach directions of an intersection should be considered. Based on the analysis of the vehicle delay on an approach of intersection, directed against the typical condition of a congested intersection-over-saturated condition, the paper has analyzed and inferred the intersection delay dynamic formulation, and has established the relation between intersection delay,the signal timings, vehicle arrival rate and the queue lengths, and that provides useful information for understanding vehicle delay of signalized intersection and for establishing performance index function of signal timing optimization.
基金This paper is sponsored by National Natural Science Foundation of China under Grant No.50475087
文摘A method for estimating current harmonics of an induction motor is introduced which is used for sensorless monitoring of a mechanical system driven by the motor. The method is based on an adaptive signal representation and is proposed to extract weak harmonics from a noisy current signal, especially in the presence of additive interference caused by transient modulation waves. As an application, a rotor unbalance experiment of rotating machinery driven by an induction motor is carried out, The result shows that the eccentricity harmonic magnitude of a current signal obtained by the method represents the rotor unbalance conditions sensitively. Vibration analysis is used to validate the proposed method.
基金partly supported by the grants from National Natural Science Foundation of China (Nos. 31730057, 91540205, and 31571447)National Basic Research Program of China (973 Program) (2015CB553803)the Fundamental Research Funds for the Central Universities
文摘Smads are critical intracellular signal transducers for transforming growth factor-β(TGF-β) in mammalian cells. In this study, we have identified WD repeat-containing protein 74(WDR74) as a novel transcriptional coactivator for Smads in the canonical TGF-β signaling pathway. Through direct interactions with Smad proteins, WDR74 enhances TGF-β-mediated phosphorylation and nuclear accumulation of Smad2 and Smad3. Consequently, WDR74 enables stronger transcriptional responses and more robust TGF-β-induced physiological responses. Our findings have elucidated a critical role of WDR74 in regulating TGF-β signaling.
基金supported by the Natural Science Fund for Distinguished Young Scholars of Jiangsu Province under Grant BK20220067。
文摘With the support of Vehicle-to-Everything(V2X)technology and computing power networks,the existing intersection traffic order is expected to benefit from efficiency improvements and energy savings by new schemes such as de-signalization.How to effectively manage autonomous vehicles for traffic control with high throughput at unsignalized intersections while ensuring safety has been a research hotspot.This paper proposes a collision-free autonomous vehicle scheduling framework based on edge-cloud computing power networks for unsignalized intersections where the lanes entering the intersections are undirectional,and designs an efficient communication system and protocol.First,by analyzing the collision point occupation time,this paper formulates an absolute value programming problem.Second,this problem is solved with low complexity by the Edge Intelligence Optimal Entry Time(EI-OET)algorithm based on edge-cloud computing power support.Then,the communication system and protocol are designed for the proposed scheduling scheme to realize efficient and low-latency vehicular communications.Finally,simulation experiments compare the proposed scheduling framework with directional and traditional traffic light scheduling mechanisms,and the experimental results demonstrate its high efficiency,low latency,and low complexity.
文摘In order to reduce the magnetically electromotive force of railway signal cables, combined with the basic engineering conditions for setting the interval grounding round steel, it is recommended to ground the signal cables at both ends. It is necessary to further increase the grounding measures to reduce the value of the magnetically induced electromotive force when the distance is km. At the same time, the signal cable should be installed as far away from the catenary as possible in the engineering design stage. For this reason, when the train is running in the shield tunnel, the protection of the signal cable also puts forward an objective requirement that is different from the DC power supply project. This paper investigates this.
基金supported by the National Natural Science Foundation of China(6127509961371164)+2 种基金the Natural Science Foundation of Chongqing(CSTC2012JJA40008)the Research Project of Chongqing Educational Commission(KJ120525KJ130524)
文摘A key issue to be addressed in stem cell biology is the molecular signaling mechanism controlling embryonic stem （ES） cell pluripotency. Stem cell properties are dictated by specific transcription factors and epigenetic processes such as DNA methylation and chromatin remodeling. Several cytokines/growth factors have been identified as critical ES cell regulators. However, there is a gap in our knowledge of the intracellular signaling pathways linking extracellular signals to transcriptional regulation in ES cells. This short review discusses the physiological role of Shp2, a cytoplasmic tyro- sine phosphatase, in the molecular switch governing ES cell self-renewal versus differentiation. Shp2 promotes ES cell differentiation, mainly through bi-directional modulation of Erk and Stat3 pathways. Deletion of Shp2 in mouse ES cells results in more efficient self-renewal. This observation provides the impetus to develop Shp2 inhibitors for maintenance and amplification of ES cells in culture.
基金Project supported by the National Natural Science Foundation of China(Grant No.61371164)the Chongqing Municipal Distinguished Youth Foundation,China(Grant No.CSTC2011jjjq40002)the Research Project of Chongqing Municipal Educational Commission,China(Grant No.KJ130524)
文摘Stochastic resonance system is an effective method to extract weak signal.However,system output is directly influenced by system parameters.Aiming at this,the Levy noise is combined with a tri-stable stochastic resonance system.The average signal-to-noise ratio gain is regarded as an index to measure the stochastic resonance phenomenon.The characteristics of tri-stable stochastic resonance under Levy noise is analyzed in depth.First,the method of generating Levy noise,the effect of tri-stable system parameters on the potential function and corresponding potential force are presented in detail.Then,the effects of tri-stable system parameters w,a,b,and Levy noise intensity amplification factor D on the resonant output can be explored with different Levy noises.Finally,the tri-stable stochastic resonance system is applied to the bearing fault detection.Simulation results show that the stochastic resonance phenomenon can be induced by tuning the system parameters w,a,and b under different distributions of Levy noise,then the weak signal can be detected.The parameter intervals which can induce stochastic resonances are approximately equal.Moreover,by adjusting the intensity amplification factor D of Levy noise,the stochastic resonances can happen similarly.In bearing fault detection,the detection effect of the tri-stable stochastic resonance system is superior to the bistable stochastic resonance system.
基金supported by the National Research Foundation of Koreagrant funded by the Korean Government(MSIP,No.2015R1D1-AIA09057204)
文摘The prevalence of cardiovascular diseases(CVDs)is increasing at a rapid pace in developed countries,and CVDs are the leading cause of morbidity and mortality.Natural products and ethnomedicine have been shown to reduce the risk of CVDs.Schizonepeta(S.)tenuifolia is a medicinal plant widely used in China,Korea,and Japan and is known to exhibit anti-inflammatory,antioxidant,and immunomodulatory activities.We hypothesized that given herbal plant exhibit pharmacological activities against CVDs,we specifically explored its effects on platelet function.Platelet aggregation was evaluated using standard light transmission aggregometry.Intracellular calcium mobilization was assessed using Fura-2/AM,and granule secretion(ATP release)was measured in a luminometer.Fibrinogen binding to integrin a_(Ⅱb)β_3,was assessed using flow cytometry.Phosphorylation of mitogen-activated protein kinase(MAPK)signaling molecules and activation of the protein kinase B(Akt)was assessed using Western blot assays.S.tenuifolia,extract potently and significantly inhibited platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin a_(Ⅱb)β_3.Moreover,all extracts significantly inhibited MAPK and Akt phosphorylation.S.tenuifolia extract inhibited platelet aggregation and granule secretion,and attenuated collagen mediated GPVI downstream signaling,indicating the potential therapeutic effects of these plant extracts on the cardiovascular system and platelet function.We suggest that S.tenuifolia extract may be a potent candidate to treat platelet-related CVDs and to be used as an antiplatelet and antithrombotic agent.
基金This work was supported in part by the National Natural Science Foundation of China(NSFC)(Nos.61931016,62071344 and 61911530246)the Key Laboratory Equipment Advanced Research Fund(No.6142206200210).
文摘Frequency diverse array(FDA)radar has been studied for more than 15 years and has attracted a lot of attention due to its potential advantages over the well-known phased array radar.The representative feature of FDA is range-angle-time-dependent transmit beampattern and its underlying properties are continuously revealed in the research.The formulation and exploitation of the transmit diversity with a frequency increment is the fundamental principle,which brings extra degrees-of-freedom(DOFs)in the transmit dimension.As the FDA radar carries additional information in range,it provides more flexibility in signal processing and also brings in new technical issues.This article overviews the state-of-the-art in FDA radar area and its applications,mainly based on the progress in our group.There are two main catalogs in FDA radar area,namely coherent FDA and FDA-MIMO(multiple-input multiple-output)radars.Potential applications including target parameter estimation,ambiguous clutter suppression,and deceptive jammer suppression are discussed.
基金supported by the National Natural Science Foundation of China(61671352)the open foundation of Key Laboratory of Cognitive Radio and Information Processing,Ministry of Education(Guilin University of Electronic Technology)(CRKL160206)Xi’an University of Science and Technology Doctor(after)Start Gold Project(2017QDJ018)
文摘In order to solve the problem of coherent signal subspace method(CSSM) depending on the estimated accuracy of signal subspace, a new direction of arrival(DOA) estimation method of wideband source, which is based on iterative adaptive spectral reconstruction, is proposed. Firstly, the wideband signals are divided into several narrowband signals of different frequency bins by discrete Fourier transformation(DFT). Then, the signal matched power spectrum in referenced frequency bins is computed, which can form the initial covariance matrix. Finally, the linear restrained minimum variance spectral(Capon spectral) of signals in other frequency bins are reconstructed using sequential iterative means, so the DOA can be estimated by the locations of spectral peaks. Theoretical analysis and simulation results show the proposed method based on the iterative spectral reconstruction for the covariance matrices of all sub-bands can avoid the problem of determining the signal subspace accurately with the coherent signal subspace method under the conditions of small samples and low signal to noise ratio(SNR), and it can also realize full dimensional focusing of different sub-band data, which can be applied to coherent sources and can significantly improve the accuracy of DOA estimation.
基金supported by grants from the National Natu-ral Science Foundation of China (81972779)Ministry of Education (MOE) Key Laboratory on signaling Regulation and Targeting Therapy of Liver Cancer,and Shanghai Key Laboratory of Hepato-biliary Tumor Biology,Chinese National Key Project (2018ZX10723204-006-003)。
文摘Background: Hepatocellular carcinoma(HCC) is one of the most highly malignant tumors. Liver tumor-initiating cells(LTICs) have been considered to contribute to HCC progression and metastasis. ATP-citrate lyase(ACLY), as a key enzyme for de novo lipogenesis, has been reported to be upregulated in various tumors. However, its expression and role in HCC and LTICs remain unknown. Methods: The expressions of ACLY in HCC tissues were detected by quantitative real-time PCR(q RT-PCR), Western blotting and immunohistochemistry. Kaplan-Meier curves and Chi-square test were used to determine the clinical significance of ACLY expression in HCC patients. A series of assays were performed to determine the function of ACLY on stemness, migration and invasion of HCC cells. Luciferase reporter assay, Western blotting and immunoprecipitation were used to study the regulation of the Wnt/β-catenin signaling by ACLY. Rescue experiments were performed to investigate whether β-catenin was the mediator of ACLY-regulated stemness and migration in HCC cells. Results: ACLY was highly expressed in HCC tissues and LTICs. Overexpression of ACLY was significantly correlated with poor prognosis, progression and metastasis of HCC patients. Knockdown of ACLY remarkably suppressed stemness properties, migration and invasion in HCC cells. Mechanistically, ACLY could regulate the canonical Wnt pathway by affecting the stability of β-catenin, and Lys49 acetylation of β-catenin might mediate ACLY-regulated β-catenin level in HCC cells. Conclusions: ACLY is a potent regulator of Wnt/β-catenin signaling in modulating LTICs stemness and metastasis in HCC. ACLY may serve as a new target for the diagnosis and treatment of HCC.
基金the National Natural Science Foundation of China(61401526).
文摘Link16 data link is the communication standard of the joint tactical information distribution system(JTIDS)used by the U.S.military and North Atlantic Treaty Organization,which is applied as the opportunistic illuminator for passive radar in this paper.The time-domain expression of the Link16 signal is established,and its ambiguity function expression is derived.The timedelay dimension and Doppler dimension side peaks of which lead to the appearance of the false target during target detection.To solve the problem,the time-delay dimension and Doppler dimension side peaks suppression methods are proposed.For the problem that the conventional mismatched filter(MMF)cannot suppress the time-delay dimension side peaks,a neighborhood MMF(NMMF)is proposed.Experimental results demonstrate the effectiveness of the proposed methods.
基金Project supported partially by the National Natural Science Foundation of China(Grant Nos.11675112,11705116,11675134,and 11874310)the National Natural Science Foundation of China for the 111 Project(Grant No.B16029).
文摘Many animals can detect the multi-frequency signals from their external surroundings.The understanding for underlying mechanism of signal detection can apply the theory of vibrational resonance,in which the moderate high frequency driving can maximize the nonlinear system's response to the low frequency subthreshold signal.In this work,we study the roles of chemical autapse on the vibrational resonance in a single neuron for signal detection.We reveal that the vibrational resonance is strengthened significantly by the inhibitory autapse in the neuron,while it is weakened typically by the excitatory autapse.It is generally believed that the inhibitory synapse has a suppressive effect in neuronal dynamics.However,we find that the detection of the neuron to the low frequency subthreshold signal can be improved greatly by the inhibitory autapse.Our finding indicates that the inhibitory synapse may act constructively on the detection of weak signal in the brain and neuronal system.
基金supported by the Equipment Pre-research Field Foundation of China(61404150102)the National Postdoctoral Program for Innovative Talents(BX20180240).
文摘The hybrid waveform of linear frequency modulation and binary phase shift keying(LFM-BPSK)can take advantages of the LFM and BPSK signals,and reduce the defects of them.However,with the development of interception technology for the LFM-BPSK signal,the application of the signal is limited.In this paper,to improve the anti-interception performance of the hybrid waveform,a new waveform of LFM-BPSK with the varying chirp rate(denoted as VCR-LFM-BPSK)is designed.In this design,based on the working principle of the interception frame for the LFM-BPSK signal,different chirp rates are introduced in different sub-pulses to prevent the signal from being intercepted by the frame.Then,to further improve the anti-interception performance of the VCR-LFM-BPSK signal,the chirp rates are optimized by minimizing the interception capability of the interceptor.Moreover,based on the VCR-LFM-BPSK signal with the optimized chirp rates,the binary phases are designed via a multiobjective Pareto optimization to improve the capabilities of autocorrelation and spectrum.Simulation results demonstrate that the designed VCR-LFM-BPSK signal outperforms the traditional LFM-BPSK signal in countering the advanced interception technologies.
基金supported by the National Natural Science Foundation of China (60901066)the New Teacher Foundation of Ministry of Education (20090203120006)the Fundamental Research Funds for the Central University (10000902013)
文摘The location of a moving target based on signal fitting and sub-aperture tracking from an airborne multi-channel radar is dealt with.The proposed approach is applied in two steps：first,the ambiguous slant-range velocity is derived with a modified single-snapshot multiple direction of arrival estimation method,and second,the unambiguous slant-range velocity is found using a track-based criterion.The prominent advantage of the proposed approach is that the unambiguous slant-range velocity can be very large.Besides,the first stage is carried out at the determinate range-Doppler test cell by azimuth searching for fitting best to the moving target signal,therefore,the location performance would not be sacrificed in order to suppress clutter and/or interference.The effectiveness and efficiency of the proposed method are validated with a set of airborne experimental data.
