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A preliminary study on measurements of black carbon in the atmosphere of northwest Qilian Shan 被引量:13
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作者 Shuyu Zhao Jing Ming +2 位作者 Cunde Xiao Weijun Sun Xiang Qin 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2012年第1期152-159,共8页
Black carbon (BC) concentration and meteorological data are measured discontinuously from May 2009 to March 2011,at the Qilian Shan Station of Glaciology and Ecologic Environment (hereafter "QSSGEE"),located nea... Black carbon (BC) concentration and meteorological data are measured discontinuously from May 2009 to March 2011,at the Qilian Shan Station of Glaciology and Ecologic Environment (hereafter "QSSGEE"),located near the terminal of the Laohugou No.12 Glacier in northwestern Qilian Shan,China.We measured the daily,monthly and seasonal variations of BC concentration in the atmosphere and discussed the possible emission sources.Black carbon background concentration in this region varied in the range of 18–72 ng/m 3 with the highest in summer and the lowest in autumn.The relations between BC concentration and surface wind direction indicated that BC concentration was higher when northwest wind prevails while lower when southeast wind prevails.Air masses backward trajectories showed the potential emission sources in the northwest.Significant positive correlations between daily mean BC concentration and relative humidity indicated that BC might be one of important cloud condensation nuclei.This hypothesis needs to be confirmed further through cloud microphysical features in this region. 展开更多
关键词 black carbon Qilian Shan cloud condensation nuclei
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Spatial Distribution of the Debris Layer on Glaciers of the Tuomuer Peak, Western Tian Shan 被引量:6
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作者 王林 李忠勤 王飞腾 《Journal of Earth Science》 SCIE CAS CSCD 2011年第4期528-538,共11页
This article, based on the field work took place on the zone of Tuomuer (托木尔) Peak, western Tian Shan (天山 ) during the period May 2008 to September 2009, obtained the spatial distribution of debris layer on t... This article, based on the field work took place on the zone of Tuomuer (托木尔) Peak, western Tian Shan (天山 ) during the period May 2008 to September 2009, obtained the spatial distribution of debris layer on the reference glaciers (Glacier No. 72, Glacier No. 74, Tuomuer Glacier) by detailed measurements of debris thickness and ablation rates on glacier and further by Spot-5 (5 m, 2005) high-resolution satellitic image applying remote sensing and geographic information systems approach to research the spatial distribution of debris layer on the zone of Tuomuer Peak. Specifically, the results indicate a sharp in ablation with debris cover thickness increasing from 0-4 cm followed by a decrease in ablation with debris thickness increasing beyond 4 cm for the glaciers No. 72 and No. 74. Spatial distributions of debris layer on the three reference glaciers have the same characteristics, the overall distribution from the vertical, the maximum thickness of debris in the glacier terminal, and the thickness of debris is constantly thinning since the end of the glacier increases with altitude. For the overall distribution from the horizontal, the regular pattern of debris thickness from both sides to the middle is diminishing. The debris on the zone of Tuomuer Peak mostly covered the glacier tongue and is mainly distributed below the altitude of 4 000 m; the area of debris covered approximate accounted for 14.9% on the entire glacier area in this region. Spatial distribution of debris layer on the zone of Tuomuer Peak is mainly affected by the elevation of the glacier terminal, followed by the slopes orientation, the sizes, and so on. 展开更多
关键词 Glacier No. 72 Glacier No. 74 Tuomuer Glacier debris covered distribution characteristics.
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Deposition Process of Dust Microparticles from Aerosol to Snow-Firn Pack on Glacier No. 1 in Eastern Tianshan Mountains, China 被引量:3
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作者 尤晓妮 董志文 《Journal of Earth Science》 SCIE CAS CSCD 2011年第4期460-469,共10页
ABSTRACT: Samples were continuously collected from aerosol, fresh snow, and snow pits on Glacier No. 1 at Urumqi River source in eastern Tianshan (天山) Mountains. The deposition processes and the characteristics o... ABSTRACT: Samples were continuously collected from aerosol, fresh snow, and snow pits on Glacier No. 1 at Urumqi River source in eastern Tianshan (天山) Mountains. The deposition processes and the characteristics of mineral dust microparticles from aerosol to fresh snow, and then evolution to the snow pit were determined. Total dust microparticle concentration in the surface snow and aerosol showed a similar temporal variation trend, which was strongly associated with regional and local at- mospheric circulation in the Tianshan Mountains region of Central Asia. Especially from November to February, the correlation coefficient of microparticles concentration in surface snow and aerosol is very high (R2=0.7). Vertical profiles of microparticles in the snow pits showed that observed dust layers were in high correlation with concentration peaks of large microparticles (d〉10 μm), but low correlation with that of fine microparticles (d〈1μm). Moreover, explicit post-depositional process of dust particles was studied by tracking some typical dust concentration peaks in the snow pit. We find that late sum- mer is a key period for post-deposition of dust particles in the snow, as particle concentration peaks in the snow pit evolve intensely during this period. Such evolutional pattern of large particles makes it possible to preserve information of atmospheric dust in the snow, which offers an available proof to reconstruct historical climate using ice cores on Glacier No. 1 and other gla- ciers in the Tianshan Mountains. 展开更多
关键词 Glacier No. 1 dust microparticle post-deposition.
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High-precision measurements of the inter-annual evolution for Urumqi Glacier No.1 in eastern Tien Shan,China 被引量:1
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作者 ChunHai Xu ZhongQin Li +2 位作者 JianXin Mu PuYu Wang FeiTeng Wang 《Research in Cold and Arid Regions》 CSCD 2021年第6期474-487,共14页
High-precision measuring of glacier evolution remains a challenge as the available global and regional remote sensing techniques cannot satisfactorily capture the local-scale processes of most small-and medium-sized m... High-precision measuring of glacier evolution remains a challenge as the available global and regional remote sensing techniques cannot satisfactorily capture the local-scale processes of most small-and medium-sized mountain glaciers.In this study,we use a high-precision local remote sensing technique,long-range terrestrial laser scanning(TLS),to measure the evolution of Urumqi Glacier No.1 at an annual scale.We found that the dense point clouds derived from the TLS survey can be used to reconstruct glacier surface terrain,with certain details,such as depressions,debris-covered areas,and supra-glacial drainages can be distinguished.The glacier experienced pronounced thickness thinning and continuous retreat over the last four mass-balance years(2015−2019).The mean surface slope of Urumqi Glacier No.1 gradually steepened,which may increase the removal of glacier mass.The glacier was deeply incised by two very prominent primary supra-glacial rivers,and those rivers presented a widening trend.Extensive networks of supra-glacial channels had a significant impact on accelerated glacier mass loss.High-precision measuring is of vital importance to understanding the annual evolution of this type of glacier. 展开更多
关键词 glacier thickness change front variation supra-glacial drainage pathway long-range terrestrial laser scanning(TLS) climate change
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Post-Disaster Reconstruction of Alishan Tsou Tribe in Different Place and Sustainable Development
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作者 Hsiao-Ming Chang Chiu-Hui Hung Han-Ming Lin 《Open Journal of Applied Sciences》 2021年第4期458-468,共11页
After the Morakot disaster in 2009, the affected indigenous tribes suffered from the government’s use of permanent housing as a single reconstruction option, which forced the victims to leave their original land for ... After the Morakot disaster in 2009, the affected indigenous tribes suffered from the government’s use of permanent housing as a single reconstruction option, which forced the victims to leave their original land for a new life in a different reconstruction mode. The purpose of this study is to explore the ways adopted by tribal residents to maintain their own culture and tribal life in the process of disaster, post disaster reconstruction and post disaster adjustment. Veoveoana Village in Taiwan is an indigenous tribe that relocated after a disaster and was reconstructed and developed through tourism development. This study performed the research by participant observation and in-depth interviews on Veoveoana Village. The analytical results showed that: 1) development of the tourism industry can result in cultural reconstruction of the post-disaster tribe and maintain the people’s incomes;2) although the government constantly assists with the rehabilitation of tribal industry by various policies, the implementation cannot effectively continue and the outcome is insignificant;3) due to the gap between permanent prefabricated housing and original tribal cultural features, the residential rate is not high. According to the research findings, it is suggested that, in the process of post-disaster reconstruction, the government and private non-profit organizations should respect the intention of the majority of the indigenous people. In addition, it should cultivate professional manpower for the subsidized projects. 展开更多
关键词 Post-Disaster Reconstruction Typhoon Morakot Indigenous Tourism Veoveoana Village Tsou Culture
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钛合金栅格薄壁结构电弧熔丝增材制造路径规划与应力控制
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作者 郑元翾 彭司弋 +3 位作者 王协彬 郭跃岭 吕忠利 刘长猛 《航空材料学报》 北大核心 2026年第1期41-50,共10页
电弧熔丝增材制造(wire-arc additive manufacturing,WAAM)以金属丝材为填充材料、电弧为热源,在大型复杂构件制造中具有显著优势,但存在制备周期长,路径规划复杂及残余应力显著等问题。针对电弧熔丝增材制造制备复杂结构件时,不合理制... 电弧熔丝增材制造(wire-arc additive manufacturing,WAAM)以金属丝材为填充材料、电弧为热源,在大型复杂构件制造中具有显著优势,但存在制备周期长,路径规划复杂及残余应力显著等问题。针对电弧熔丝增材制造制备复杂结构件时,不合理制备路径导致的残余应力集中与应变缺陷,使用有限元仿真软件优化沉积路径,并基于优化路径制备成形质量良好的栅格构件单元体。结果表明:未优化路径冷却后,薄壁处等效残余应力为361 MPa,节点处高达666 MPa;而优化路径冷却后薄壁处等效残余应力将至206 MPa,两节点处分别为260、427 MPa。相较于未优化路径,优化路径节点残余应力最大降幅61%,薄壁应力降幅43%,且节点与薄壁的应力差异显著降小,残余应力诱发的形变与缺陷明显降低。采用优化路径制备的栅格构件单元体熔道结合紧密、成形质量良好,无明显残余应力变形,验证了此优化路径在电弧熔丝增材制造栅格构件残余应力控制中的可行性。 展开更多
关键词 电弧熔丝增材制造 钛合金构件 有限元分析 路径规划
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基于改进野狗优化算法的无人机-骑手联合外卖配送路径优化
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作者 卢福强 汪夏 +1 位作者 毕华玲 王喆 《管理工程学报》 北大核心 2026年第1期262-273,共12页
外卖已成为一种普遍的消费模式。在外卖消费过程中,顾客不仅在乎餐品是否美味,还对餐品的送达时间有要求。影响外卖配送质量的因素不仅有送达时间,还有配送成本。基于上述问题,本文考虑以顾客满意度最大化和送餐成本最小化为目标函数,... 外卖已成为一种普遍的消费模式。在外卖消费过程中,顾客不仅在乎餐品是否美味,还对餐品的送达时间有要求。影响外卖配送质量的因素不仅有送达时间,还有配送成本。基于上述问题,本文考虑以顾客满意度最大化和送餐成本最小化为目标函数,引入无人机来辅助骑手进行外卖配送,建立了无人机-骑手联合外卖配送模型。本文借鉴遗传算法的交叉变异操作思路对配送方案进行优化改进,在此基础上,为进一步提升求解效果,最后采用精英策略并结合相关优化理念,提出一种改进野狗优化算法(improved dingo optimization algorithm,IDOA),对该模型进行求解。为确定骑手外卖配送餐品的最优数量,本文进行了灵敏度分析,得到每名骑手配送餐品的最优数量。通过对两种配送方式在不同规模算例下进行对比分析,结果表明,改进野狗优化算法能够有效解决当前外卖配送中送达时间长的问题,从而降低了外卖配送成本,提升了顾客满意度,对外卖企业的发展具有重要意义。 展开更多
关键词 外卖配送 无人机 联合配送 路径优化 野狗优化算法
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Early GLP-1 Agonist Use and Cancer Risk in Type 2 Diabetes:A Real-World Data Cohort Study
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作者 Cheng-Hsun Chuang Ping-Kun Tsai +2 位作者 Shih-Wen Kao Yu-Hsun Wang Chao-Bin Yeh 《Oncology Research》 2026年第1期237-253,共17页
Background:To determine whether initiating a glucagon-like peptide-1 receptor agonist(GLP-1 RA)within 3 months of type 2 diabetes(T2DM)diagnosis alters the subsequent risk of overall and site-specific cancer and wheth... Background:To determine whether initiating a glucagon-like peptide-1 receptor agonist(GLP-1 RA)within 3 months of type 2 diabetes(T2DM)diagnosis alters the subsequent risk of overall and site-specific cancer and whether this association differs by baseline body-mass index(BMI).Methods:This retrospective cohort study used electronic health records from the TriNetX U.S.research network.Adults aged 20 years or older diagnosed with T2DM between 2016 and 2024 were included if they received any hypoglycemic agents within 3 months before and after diagnosis.Following 1:1 propensity score matching,both the GLP-1 RA user and non-user groups included 183,264 patients.The study outcome was defined as a diagnosis of malignant neoplasms.Hazard ratios(HRs)for overall and site-specific cancer risk were estimated using Cox proportional hazards models.Kaplan–Meier analysis and stratified analysis by BMI were performed.Results:Early GLP-1 RA use demonstrated a modest but significant association with reduced overall cancer risk(HR 0.93;95%CI:0.90–0.96).Reduced risks were noted for cancers of the digestive(HR 0.81),respiratory(HR 0.66),and female genital(HR 0.87)systems.In stratified analysis,benefits were more pronounced in patients with BMI≥30,particularly for pancreatic and colorectal cancers.Conclusion:Early initiation of GLP-1 receptor agonists in patients with diagnosed T2DM was associated with a modest reduction in overall cancer risk,particularly among individuals with obesity.These findings highlight the dual metabolic and oncologic value of prompt GLP-1 RA therapy. 展开更多
关键词 Glucagon-like peptide-1(GLP-1)receptor agonists type 2 diabetes mellitus cancer risk OBESITY cohort study
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慢性病患者基层用药体验量表的研制及其信效度检验
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作者 邵佳娴 曹海虹 +7 位作者 孙志红 李晓娜 高敏 李子源 时永利 董平 尹文强 陈钟鸣 《中国全科医学》 北大核心 2026年第4期509-517,共9页
背景改善患者用药体验是提高患者用药依从性的关键因素,也是改善患者预后和医疗安全的必要条件。目前我国慢性病患者基层用药体验测量工具欠缺,严重掣肘了基层医疗卫生机构药事服务和管理的研究和实践工作。目的本研究旨在研制适用于我... 背景改善患者用药体验是提高患者用药依从性的关键因素,也是改善患者预后和医疗安全的必要条件。目前我国慢性病患者基层用药体验测量工具欠缺,严重掣肘了基层医疗卫生机构药事服务和管理的研究和实践工作。目的本研究旨在研制适用于我国慢性病管理实践的慢性病患者基层用药体验量表,并进行信效度检验,以期为慢性病患者健康管理研究和实践提供工具支持。方法本研究采用定性与定量相结合的方式进行量表研制。通过文献分析法初步构建量表条目池,通过半结构化访谈法并在感知价值理论指导下形成初步的慢性病患者基层用药体验量表。通过德尔菲专家咨询法对初步编制的慢性病患者基层用药体验量表进行咨询论证,并修改完善。于2023年10月,在山东省基层医疗卫生机构采用随机抽样方法,选取基层就诊的慢性病患者进行现场调研,对量表进行语言文化调试及量表的信度和效度检验,对量表做出进一步的优化和调整,最终形成慢性病患者基层用药体验量表。结果通过文献分析法提取了14个用药体验相关维度,通过半结构化访谈法初步构建了包含8个维度、40个条目的量表条目池。通过德尔菲专家咨询法对量表进行了修改完善,两轮专家积极性分别为95%和100%,专家权威系数平均值分别为0.86和0.88,专家对量表提出了较为科学权威的修改意见和建议,形成了包含7个维度、29个条目的量表。通过现场调研,量表的信效度检验结果较好,量表条目临界比值法分析结果显示,P值均<0.05,总表及各维度Cronbach'sα系数均>0.800,折半信度均>0.700,组内相关系数(ICC)均>0.800。旋转后各条目因子载荷量均>0.500;验证性因子分析模型拟合指标结果为卡方自由度比(CMIN/DF)=1.485,适配度指数(GFI)=0.902,渐进残差均方和平方根(RMSEA)=0.039,均方根残差(RMR)=0.03,比较适配指数(CFI)=0.981,规准适配指数(NFI)=0.945,增值适配指数(IFI)=0.981,量表建构信度(CR)值均>0.7,平均方差提取值(AVE)均>0.500。最终形成了包括功能价值、情感价值、社会价值3个一级维度、7个二级维度、28个测量条目的慢性病患者基层用药体验量表。结论本研究研制的慢性病患者基层用药体验量表具有较好的信度和效度,具有较好的本土适宜性,可以用于慢性病患者基层用药体验调查研究。 展开更多
关键词 慢性病 用药体验 患者体验 量表研制
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长效微球载药体系在精神障碍类疾病治疗中的研究进展
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作者 曹嵩嵩 杜丽平 +2 位作者 张丽 郝贵周 张贵民 《临床研究》 2026年第1期190-198,共9页
微球作为治疗精神障碍类疾病的新型载药体系,成为医学界广泛关注的热点。本研究综述了国内外文献对长效微球载药体系治疗及监测精神障碍类疾病(精神分裂症、抑郁症、阿尔茨海默病、双相情感障碍、癫痫等)的研究,提出微球在精神障碍疾病... 微球作为治疗精神障碍类疾病的新型载药体系,成为医学界广泛关注的热点。本研究综述了国内外文献对长效微球载药体系治疗及监测精神障碍类疾病(精神分裂症、抑郁症、阿尔茨海默病、双相情感障碍、癫痫等)的研究,提出微球在精神障碍疾病应用中的优势与不足等方面的思考,以期为治疗精神障碍类疾病长效微球载药体系的研发和临床转化提供参考。 展开更多
关键词 精神障碍类疾病 微球 长效载药体系
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Investigation and control of a Plasmodium falciparum malaria outbreak in Shan Special Region II of Myanmar along the China-Myanmar Border from June to December 2014 被引量:5
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作者 Hui Liu Jian-Wei Xu +9 位作者 Heng-Lin Yang Mei Li Cheng-De Sun Yi-Jie Yin Zhi-Liang Zheng Guang-Yun Zhang Ai-Shui Yu Yong-Hui Yang Chun-Hui Li Shui Ai 《Infectious Diseases of Poverty》 SCIE 2016年第1期277-287,共11页
Background:From 2007 to 2013,intensive control measures reduced malaria burden by 90%along the China-Myanmar border.However,despite these measures a P.falciparum malaria outbreak was reported in the Shan Special Regio... Background:From 2007 to 2013,intensive control measures reduced malaria burden by 90%along the China-Myanmar border.However,despite these measures a P.falciparum malaria outbreak was reported in the Shan Special Region II of Myanmar in June of 2014.Methods:Epidemiological,parasitological and entomological investigations were performed.Dihydroartemisinin piperaquine(DAPQ)was immediately administered to treat parasite positive individuals.Long lasting insecticidal nets(LLIN),indoor residual spraying(IRS)with insecticides and behavior change communication(BCC)were also provided for outbreak control.An embedded efficacy study was conducted evaluating DP.Molecular genotyping via polymerase chain reaction(PCR)was performed on the Kelch gene on chromosome 13.Results:All infections were identified as Plasmodium falciparum by RDT and microscopy.Two fatalities resulted from the outbreak.The attack rate was 72.8%(67/92)and the incidence density rate was 14.2 per 100 person-weeks.The positive rate of rapid diagnostic test(RDT)was 72.2%(65/90)and microscopically-determine parasite rate 42.2%(38/90).Adjusted odds ratio(OR)of multivariate logistic regression analysis for aged<15 years,15–45 years,inappropriate treatment from a private healer and lack of bed nets were 13.51(95%confidence interval,2.21–105.89),7.75(1.48–44.97),3.78(1.30–46.18)and 3.21(1.21–15.19)respectively.In the six surrounding communities of the outbreak site,positive RDT rate was 1.2%(4/328)and microscopically-determine parasite rate 0.6%(2/328).Two light traps collected a total of 110 anopheline mosquitoes including local vectors,An.minimus,An.sinensis and An.maculates.After intensive control,the detection of malaria attacks,parasites and antigen were reduced to zero between July 1 and December 1,2014.The cure rate of P.falciparum patients at day 42 was 94.3%(95%CI,80.8–99.3%).The PCR did not detect K13-propeller mutations.Conclusion:Imported P.falciparum caused the outbreak.Age,seeking inappropriate treatment and lack of bed nets were risk factors for infection during the outbreak.P.falciparum was sensitive to treatment with DAPQ.The integrated measures controlled the outbreak and prevented the spread of P.falciparum effectively.The results of this study indicate that malaria control on the China-Myanmar border,especially among special populations,needs further collaboration between China,Myanmar and international societies. 展开更多
关键词 Malaria outbreak Plasmodium falciparum INVESTIGATION Control Chinese-Myanmar borde
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Providing financial incentives to rural-to-urban tuberculosis migrants in Shanghai: an intervention study 被引量:1
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作者 Xiaolin Wei Guanyang Zou +4 位作者 Jia Yin John Walley Huaixia Yang Merav Kliner Jian Mei 《Infectious Diseases of Poverty》 SCIE 2012年第1期84-91,共8页
Background:Financial issues are major barriers for rural-to-urban migrants accessing tuberculosis(TB)care in China.This paper discusses the effectiveness of providing financial incentives to migrant TB patients(with a... Background:Financial issues are major barriers for rural-to-urban migrants accessing tuberculosis(TB)care in China.This paper discusses the effectiveness of providing financial incentives to migrant TB patients(with a focus on poor migrants in one district of Shanghai using treatment completion and default rates),the effect of financial incentives in terms of reducing the TB patient cost,and the incremental cost-effectiveness ratio of the intervention.Results:Ninety and ninety-three migrant TB patients were registered in the intervention and control districts respectively.TB treatment completion rates significantly improved by 11%(from 78%to 89%)in the intervention district,compared with only a 3%increase(from 73%to 76%)in the control district(P=0.03).Default rates significantly decreased by 11%(from 22%to 11%)in the intervention district,compared with 1%(from 24%to 23%)in the control district(P=0.03).In the intervention district,the financial subsidy(RMB 1,080/US$170)accounted for 13%of the average patient direct cost(RMB 8,416/US$1,332).Each percent increase in treatment completion costs required an additional RMB 6,550(US$1,301)and each percent reduction in defaults costs required an additional RMB 5,240(US$825)in the intervention district.Conclusions:Overall,financial incentives proved to be effective in improving treatment completion and reducing default rates among migrant TB patients in Shanghai.The results suggest that financial incentives can be effectively utilized as a strategy to enhance case management among migrant TB patients in large cities in China,and this strategy may be applicable to similar international settings. 展开更多
关键词 Public health TUBERCULOSIS Domestic migrants POVERTY Financial incentive Treatment completion Effectiveness
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红花多糖对结直肠癌小鼠肿瘤生长及磷脂酰肌醇3-激酶/蛋白激酶B/雷帕霉素靶蛋白信号通路的影响 被引量:1
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作者 王伟 王敏 +1 位作者 成敏敏 张婷婷 《实用医学杂志》 北大核心 2025年第5期670-675,共6页
目的探讨红花多糖对结直肠癌小鼠肿瘤生长的作用及对磷脂酰肌醇3-激酶(phosphoinositide 3-kinase,PI3K)/蛋白激酶B(protein kinase B,Akt)/雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)信号通路的影响。方法接种结直肠癌SW480... 目的探讨红花多糖对结直肠癌小鼠肿瘤生长的作用及对磷脂酰肌醇3-激酶(phosphoinositide 3-kinase,PI3K)/蛋白激酶B(protein kinase B,Akt)/雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)信号通路的影响。方法接种结直肠癌SW480细胞建立结直肠癌肿瘤小鼠模型,将建模成功小鼠分为模型组、红花多糖低剂量组[15 mg/(kg·d)]、红花多糖中剂量组[45 mg/(kg·d)]、红花多糖高剂量组[135 mg/(kg·d)],给药结束后,测定小鼠肿瘤体积、质量和抑瘤率;免疫组化染色法检测增殖细胞核抗原(PCNA)蛋白表达;脱氧核糖核苷酸末端转移酶介导的缺口末端标记法(TUNEL)检测细胞凋亡情况;苏木精伊红(HE)染色观察小鼠肿瘤组织形态;实时荧光定量聚合酶链反应(RT-PCR)法检测各组小鼠肿瘤组织PI3K、Akt、mTOR表达水平;免疫印迹法检测各肿瘤组织c-Myc、Bcl-2关联X蛋白(Bcl-2-associated X protein,Bax)、PI3K/Akt/mTOR通路蛋白表达水平。结果与模型组相比,红花多糖(低、中、高)剂量组小鼠肿瘤质量和肿瘤体积、PI3K、Akt、mTOR mRNA及p-PI3K/PI3K、p-Akt/Akt、p-mTOR/mTOR表达水平、c-Myc蛋白降低,Bax蛋白表达升高(P<0.05),随红花多糖浓度升高,抑瘤率也呈升高趋势(P<0.05)。模型组小鼠肿瘤组织中有较多的PCNA阳性细胞;TUNEL染色阳性细胞(绿色)表达很少,细胞凋亡率较低;肿瘤组织细胞排列紧密,体积较大,分化程度较低;红花多糖各剂量组小鼠肿瘤组织中PCNA表达显著减少,TUNEL染色阳性细胞(绿色)显著增加,细胞凋亡率升高(P<0.05),肿瘤组织细胞排列松散,细胞核皱缩,有较多坏死细胞。结论红花多糖可能通过抑制PI3K/Akt/mTOR信号通路来抑制结直肠癌小鼠肿瘤生长。 展开更多
关键词 红花多糖 结直肠癌 PI3K/Akt/mTOR信号通路 肿瘤生长 增殖细胞核抗原 细胞凋亡 C-MYC Bcl-2关联X蛋白
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Associations among Distress Rumination,Somatic Anxiety,and Suicidal Ideation in Chinese College Students—Shandong Province,China,2019–2020
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作者 Guoxiao Sun Zhiyao Ma +4 位作者 Zongyu Liu Jenny Huen Bob Lew Augustine Osman Cunxian Jia 《China CDC weekly》 SCIE CSCD 2023年第25期554-558,共5页
Summary What is already known about this topic?The literature has consistently demonstrated that distress rumination following a traumatic event has significant implications for mental health.However,the potential ass... Summary What is already known about this topic?The literature has consistently demonstrated that distress rumination following a traumatic event has significant implications for mental health.However,the potential association between distress rumination and suicidality,as well as the underlying mechanisms driving this relationship,remains to be elucidated.What is added by this report?The current study demonstrated a significant,positive correlation between distress rumination and suicidal ideation in college students who have encountered traumatic events.The findings indicate that somatic anxiety serves as a mediator between distress rumination and suicidal ideation.What are the implications for public health practice?Interventions aimed at reducing somatic anxiety may contribute to a decrease in suicidal ideation.Assessing and addressing somatic anxiety symptoms in college students experiencing distressful rumination following traumatic events could potentially lower the risk of suicide. 展开更多
关键词 DISTRESS driving college
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连续梁桥局部桥跨爆破拆除技术研究 被引量:2
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作者 郑选荣 任凯 +2 位作者 刘蕊 李帅良 岳雪茹 《爆破》 北大核心 2025年第2期129-139,共11页
连续梁桥部分桥跨爆破拆除时极易对邻近桥跨产生较大的损害,为同时保证桥梁倒塌破碎效果和相邻桥跨的安全,以安康市某连续梁桥病害部分桥跨拆除爆破工程为例,利用ANSYS/LS-DYNA软件分别对上部箱梁水压爆破和下部桥墩逐排倾斜倒塌、逐跨... 连续梁桥部分桥跨爆破拆除时极易对邻近桥跨产生较大的损害,为同时保证桥梁倒塌破碎效果和相邻桥跨的安全,以安康市某连续梁桥病害部分桥跨拆除爆破工程为例,利用ANSYS/LS-DYNA软件分别对上部箱梁水压爆破和下部桥墩逐排倾斜倒塌、逐跨倾斜倒塌、从中间向两边倾斜倒塌进行了模拟分析,根据桥体破碎效果、桥梁倒塌姿态以及塌落振动速度确定了最佳爆破方案,依据模拟结果进行了爆破设计并对振动速度进行了安全校核。结果表明:上部箱梁水压爆破梁体较为破碎,且爆破飞石较少防止其对邻近桥跨产生较大的冲击;在爆破前变连续梁为简支梁,并在爆破时先起爆邻近桥跨主梁处药包,随后下部桥墩采用逐排倾斜的倒塌方案可以在保证桥梁倒塌破碎效果的同时减小振动速度确保邻近桥跨的安全;现场实际桥梁爆破效果较好,且倒塌过程与数值模拟结果大体一致,邻近桥墩处无明显损伤,数值模拟监测点处最大振速峰值为3.58 cm/s,现场监测为3.96 cm/s,数值模拟结果较为准确。 展开更多
关键词 拆除爆破 水压爆破 连续梁桥 局部桥跨 振动速度
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齐元富基于“解毒”治疗观辨治肺癌经验 被引量:2
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作者 夏蕾 谭兆峰 +1 位作者 秘亚鑫 齐元富(指导) 《山东中医杂志》 2025年第1期105-107,111,共4页
齐元富教授重视毒邪在肺癌发生、发展中的重要作用,“解毒”是其治疗肺癌的经验特色之一。齐教授将导致肺癌的毒邪分为热毒、郁毒、痰毒、瘀毒四种类型,热毒者主以清热解毒治之,郁毒者主以理气消癥治之,痰毒者主以化痰除湿治之,瘀毒者... 齐元富教授重视毒邪在肺癌发生、发展中的重要作用,“解毒”是其治疗肺癌的经验特色之一。齐教授将导致肺癌的毒邪分为热毒、郁毒、痰毒、瘀毒四种类型,热毒者主以清热解毒治之,郁毒者主以理气消癥治之,痰毒者主以化痰除湿治之,瘀毒者主以活血散结治之,临床常获佳效。附验案1则。 展开更多
关键词 肺癌 解毒 热毒 郁毒 痰毒 瘀毒 齐元富
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微创皮质截骨联合髓内钉固定治疗陈旧性胫腓骨骨折
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作者 张伟强 罗文明 +4 位作者 史兴振 高加智 李飞 赵刚 吴倩 《中国矫形外科杂志》 北大核心 2025年第21期2001-2005,共5页
[目的]观察微创皮质截骨联合髓内钉固定治疗陈旧性胫腓骨骨折的临床效果。[方法]2021年10月—2023年2月,本科对13例骨折端存在不同程度畸形的3周以上陈旧性胫腓骨骨折患者行手术治疗。术中行骨折端小切口皮质截骨,松解周围软组织,牵引... [目的]观察微创皮质截骨联合髓内钉固定治疗陈旧性胫腓骨骨折的临床效果。[方法]2021年10月—2023年2月,本科对13例骨折端存在不同程度畸形的3周以上陈旧性胫腓骨骨折患者行手术治疗。术中行骨折端小切口皮质截骨,松解周围软组织,牵引恢复胫骨力线和长度,随后常规进行髌上入路髓内钉固定。评价临床和影像资料。[结果]13例患者均顺利完成手术,术中均无重要血管神经损伤。随访12个月以上,临床骨折愈合时间(7.8±1.5)个月,随术前、术后3个月和末次随访的时间推移,VAS评分[(5.7±1.7)分,(1.6±0.7)分,(1.2±0.4)分,P<0.001]、HSS评分[(54.1±7.0)分,(87.7±2.7)分,(91.5±2.7)分,P<0.001]、膝伸屈ROM[(92.3±9.3)°,(121.3±25.8)°,(130.6±17.6)°,P<0.001]、踝AOFAS评分[(69.5±4.6),(88.0±2.9),(99.5±0.8),P<0.001]均显著改善。随访过程中,所有患者均无再骨折,无翻修手术。影像方面,随时间推移,患者胫骨对线显著改善[例,优/良/差,(0/0/13),(4/9/0),(10/3/0),P<0.001],双侧胫骨长度差显著缩小[(7.3±5.3)mm,(1.3±1.0)mm,(0.4±0.3)mm,P<0.001]。术后骨痂形成时间为(7.0±1.5)周,至末次随访时,13例患者均达到完全骨折愈合塑形,均无内固定物松动或断裂。[结论]骨折处小切口截骨可有效辅助陈旧性胫骨骨折复位和髓内钉固定,微创操作,对骨折端血运影响小,取得满意临床结果。 展开更多
关键词 陈旧性胫腓骨骨折 成角畸形 微创皮质截骨术 髓内钉
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基于生成式AIGC的非遗香云纱与马面裙融合创新设计研究 被引量:1
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作者 付丽娜 《江苏丝绸》 2025年第3期42-49,共8页
随着生成式AI(Artificial Intelligence Generated Content,简称AIGC)技术的飞速发展,其在创意设计领域的应用日益广泛。本文以非遗香云纱与马面裙的融合创新设计为研究对象,探讨生成式AI技术在传统服饰文化现代转化中的应用。通过文献... 随着生成式AI(Artificial Intelligence Generated Content,简称AIGC)技术的飞速发展,其在创意设计领域的应用日益广泛。本文以非遗香云纱与马面裙的融合创新设计为研究对象,探讨生成式AI技术在传统服饰文化现代转化中的应用。通过文献综述、案例分析和实践应用,本文总结生成式AI在非遗服饰设计中的优势与局限性,提出基于生成式AI的非遗香云纱与马面裙融合创新设计的方法,并通过设计实践验证该方法的可行性与有效性。 展开更多
关键词 生成式AI 非遗香云纱 马面裙 融合创新设计
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我国能源企业生物多样性保护主流化管理路径
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作者 宋阳 柳军 +4 位作者 何少林 徐薇 程琛 刘博 余绩庆 《生物多样性》 北大核心 2025年第1期133-145,共13页
生物多样性是人类赖以生存和社会经济可持续发展的重要基础,多数能源开发空间与生态空间重叠,能源开发利用对生物多样性的影响一直备受关注,特别是可再生能源建设和运营过程兼顾生物多样性保护已经成为能源行业绿色转型的必然要求。对... 生物多样性是人类赖以生存和社会经济可持续发展的重要基础,多数能源开发空间与生态空间重叠,能源开发利用对生物多样性的影响一直备受关注,特别是可再生能源建设和运营过程兼顾生物多样性保护已经成为能源行业绿色转型的必然要求。对我国能源企业而言,参与生物多样性保护既是在应对挑战,也是在寻求机遇,作为生态文明建设的主角之一,能源企业需要探索和落实生物多样性保护主流化的各项举措。本文介绍了能源企业应遵循的国际和国内生物多样性保护政策及监管要求,总结了国内外典型能源企业参与生物多样性保护工作的经验和做法,分析了当前我国能源企业在生物多样性保护方面面临的挑战与不足,提出了我国能源企业实施生物多样性保护的原则和路径。我国现已初步建立了一套由法律法规、综合性政策和专项制度构成的具有中国特色的生物多样性保护管理体系,能源企业主要通过环境影响评价、矿山地质环境保护与土地复垦、水土保持、水资源论证和绿色矿山建设评选等途径,落实生物多样性保护。但是目前我国能源企业仍然存在生物多样性保护理念、资金和人员的三项挑战,生物多样性保护能力和披露水平有待提高。我国能源企业应将生物多样性保护融入企业管理和项目开发运营的各个环节,持续加强生物多样性保护主流化工作;构建生物多样性价值核算与实现体系,将生物多样性价值纳入企业决策;因地制宜落实多层次的保护途径,开展生物多样性监测与成效评估;充分利用国际高层次平台扩大影响力,完善生物多样性披露信息及科学性。通过以上路径积极参与全球生物多样性治理,全面提升生物多样性保护水平,有效应对我国生物多样性保护面临的挑战,促进能源开发与自然生态的和谐共生。 展开更多
关键词 能源行业 生物多样性保护 中国企业 策略
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S-烯丙基巯基半胱氨酸通过调节Th17/Treg免疫平衡抑制胃癌进展
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作者 翟健 李军 石福民 《中国免疫学杂志》 北大核心 2025年第10期2422-2426,2434,共6页
目的:探究S-烯丙基巯基半胱氨酸(SAMC)通过调节Th17/Treg免疫平衡对胃癌(GC)进展的影响。方法:100只裸鼠随机分为对照组(NC)、低剂量SAMC组(SAMC-L)、中剂量SAMC组(SAMC-M)、高剂量SAMC组(SAMC-H),每组25只。裸鼠右肩皮下注射SGC-7901... 目的:探究S-烯丙基巯基半胱氨酸(SAMC)通过调节Th17/Treg免疫平衡对胃癌(GC)进展的影响。方法:100只裸鼠随机分为对照组(NC)、低剂量SAMC组(SAMC-L)、中剂量SAMC组(SAMC-M)、高剂量SAMC组(SAMC-H),每组25只。裸鼠右肩皮下注射SGC-7901细胞悬液(0.2 ml,2×10~7个/ml)制作移植瘤模型。各组裸鼠分别注射对应剂量的0.9%氯化钠溶液和SAMC溶液(100 mg/kg、200 mg/kg、400 mg/kg);每隔2 d注射1次,连续给药3周。治疗结束后,测量移植瘤体积和质量。流式细胞术检测裸鼠外周血和移植瘤中Th17、Treg细胞比例;ELISA检测裸鼠外周血中IL-6、IL-10、IL-17、TGF-β1水平;RT-qPCR检测裸鼠外周血和移植瘤中Th17、Treg细胞相关标志物mRNA水平;Western blot检测移植瘤中Th17、Treg细胞相关标志物蛋白水平。结果:与NC组相比,SAMC-L组、SAMC-M组、SAMC-H组移植瘤体积和质量减少,外周血和移植瘤中Th17细胞、Treg、Th17/Treg比例降低,外周血中IL-6、IL-10、IL-17、TGF-β1水平降低,外周血和移植瘤中Foxp3、CTLA-4、GITR、RORγt、IL-17A mRNA和蛋白水平降低,且不同剂量SAMC组间上述效应差异有统计意义(P<0.05)。结论:SAMC可能通过调节Th17/Treg免疫平衡抑制GC进展。 展开更多
关键词 S-烯丙基巯基半胱氨酸 TH17/TREG 胃癌
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