Iced transmission line galloping poses a significant threat to the safety and reliability of power systems,leading directly to line tripping,disconnections,and power outages.Existing early warning methods of iced tran...Iced transmission line galloping poses a significant threat to the safety and reliability of power systems,leading directly to line tripping,disconnections,and power outages.Existing early warning methods of iced transmission line galloping suffer from issues such as reliance on a single data source,neglect of irregular time series,and lack of attention-based closed-loop feedback,resulting in high rates of missed and false alarms.To address these challenges,we propose an Internet of Things(IoT)empowered early warning method of transmission line galloping that integrates time series data from optical fiber sensing and weather forecast.Initially,the method applies a primary adaptive weighted fusion to the IoT empowered optical fiber real-time sensing data and weather forecast data,followed by a secondary fusion based on a Back Propagation(BP)neural network,and uses the K-medoids algorithm for clustering the fused data.Furthermore,an adaptive irregular time series perception adjustment module is introduced into the traditional Gated Recurrent Unit(GRU)network,and closed-loop feedback based on attentionmechanism is employed to update network parameters through gradient feedback of the loss function,enabling closed-loop training and time series data prediction of the GRU network model.Subsequently,considering various types of prediction data and the duration of icing,an iced transmission line galloping risk coefficient is established,and warnings are categorized based on this coefficient.Finally,using an IoT-driven realistic dataset of iced transmission line galloping,the effectiveness of the proposed method is validated through multi-dimensional simulation scenarios.展开更多
To examine the similarities and differences in the evolution of cavity,wetting and dynamics of a highspeed,oblique water-entry projectile with different positive angles of attack,a comparative analysis has been conduc...To examine the similarities and differences in the evolution of cavity,wetting and dynamics of a highspeed,oblique water-entry projectile with different positive angles of attack,a comparative analysis has been conducted based on the numerical results of two mathematical models,the rigid-body model and fluid-structure interaction model.In addition,the applicable scope of the above two methods,and the structural response characteristics of the projectile have also been investigated.Our results demonstrate that:(1) The impact loads and angular motion of the projectile of the rigid-body method are more likely to exhibit periodic variations due to the periodic tail slap,its range of positive angles of attack is about α<2°.(2) When the projectile undergone significant wetting,a strong coupling effect is observed among wetting,structural deformation,and projectile motion.With the applied projectile shape,it is observed that,when the projectile bends,the final wetting position is that of Part B(cylinder of body).With the occu rrence of this phenomenon,the projectile ballistics beco me completely unstable.(3) The force exerted on the lower surface of the projectile induced by wetting is the primary reason of the destabilization of the projectile traj ectory and structu ral deformation failure.Bending deformation is most likely to appear at the junction of Part C(cone of body) and Part D(tail).The safe angles of attack of the projectile stability are found to be about α≤2°.展开更多
Colorectal cancer(CRC)is the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide.The leading risk factors for CRC include male gender,age over 50,family history,obesity,tobacco ...Colorectal cancer(CRC)is the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide.The leading risk factors for CRC include male gender,age over 50,family history,obesity,tobacco smoking,alco-hol consumption,and unhealthy diet.CRC screening methods vary considerably between countries and depend on incidence,economic resources and healthcare structure.Important aspects of screening include adherence,which can vary signi-ficantly across ethnic and socioeconomic groups.Basic concepts of CRC screening include pre-stratification of patients by identifying risk factors and then using fecal immunochemical test or guaiac-based fecal occult blood test and/or colono-scopy or radiologic imaging techniques.Technological capabilities for CRC scree-ning are rapidly evolving and include stool DNA test,liquid biopsy,virtual colo-nography,and the use of artificial intelligence.A CRC prevention strategy should be comprehensive and include active patient education along with targeted imple-mentation of screening.展开更多
All-solid-state Li batteries(ASSLBs)using solid electrolytes(SEs)have gained significant attention in recent years considering the safety issue and their high energy density.Despite these advantages,the commercializat...All-solid-state Li batteries(ASSLBs)using solid electrolytes(SEs)have gained significant attention in recent years considering the safety issue and their high energy density.Despite these advantages,the commercialization of ASSLBs still faces challenges regarding the electrolyte/electrodes interfaces and growth of Li dendrites.Elemental doping is an effective and direct method to enhance the performance of SEs.Here,we report an Al-F co-doping strategy to improve the overall properties including ion conductivity,high voltage stability,and cathode and anode compatibility.Particularly,the Al-F co-doping enables the formation of a thin Li-Al alloy layer and fluoride interphases,thereby constructing a relatively stable interface and promoting uniform Li deposition.The similar merits of Al-F co-doping are also revealed in the Li-argyrodite series.ASSLBs assembled with these optimized electrolytes gain good electrochemical performance,demonstrating the universality of Al-F co-doping towards advanced SEs.展开更多
The operation of deep-sea underwater vehicles relies entirely on onboard batteries.However,the extreme deep-sea conditions,characterized by ultrahigh hydraulic pressure,low temperature,and seawater conductivity,pose s...The operation of deep-sea underwater vehicles relies entirely on onboard batteries.However,the extreme deep-sea conditions,characterized by ultrahigh hydraulic pressure,low temperature,and seawater conductivity,pose significant challenges for battery development.These conditions drive the need for specialized designs in deep-sea batteries,incorporating critical aspects of power generation,protection,distribution,and management.Over time,deep-sea battery technology has evolved through multiple generations,with lithium(Li)batteries emerging in recent decades as the preferred power source due to their high energy and reduced operational risks.Although the rapid progress of Li batteries has notably advanced the capabilities of underwater vehicles,critical technical issues remain unresolved.This review first systematically presents the whole picture of deep-sea battery manufacturing,focusing on Li batteries as the current mainstream solution for underwater power.It examines the key aspects of deep-sea Li battery development,including materials selection informed by electro-chemo-mechanics models,component modification and testing,and battery management systems specialized in software and hardware.Finally,it discusses the main challenges limiting the utilization of deep-sea batteries and outlines promising directions for future development.Based on the systematic reflection on deep-sea batteries and discussion on deep-sea Li batteries,this review aims to provide a research foundation for developing underwater power tailored for extreme environmental exploration.展开更多
Two new species of the Aglaostigma laticinctum subgroup belonging to A.tertium group,are described and illustrated in this study:A.leucogaster Liu,Li&Wei sp.nov.and A.rufitegula Liu,Li&Wei sp.nov.The Aglaostig...Two new species of the Aglaostigma laticinctum subgroup belonging to A.tertium group,are described and illustrated in this study:A.leucogaster Liu,Li&Wei sp.nov.and A.rufitegula Liu,Li&Wei sp.nov.The Aglaostigma laticinctum subgroup is proposed here for the first time,with a brief discussion of its diagnostic features.Additionally,a key to all known species of the A.laticinctum subgroup from China is provided.展开更多
Lightweight,high-strength,and heat-resistant protective structures have consistently been crucial for applications in extreme environments,such as aerospace,semiconductors,and nuclear power industries.Multilayered TC4...Lightweight,high-strength,and heat-resistant protective structures have consistently been crucial for applications in extreme environments,such as aerospace,semiconductors,and nuclear power industries.Multilayered TC4/TB8 titanium(Ti)laminates,inspired by theheterostructures of natural biological shells,were fabricated using a hybrid diffusion bonding-hot rolling process followed by an aging treatment,resulting in an architected micro structure.The laminate achieves an ultra-high yield stress of 1020 MPa and proper uniform elongation of 4.2%at 500℃.The TB8 layers with high-density nano-precipitates and dislocations act as hard zone,contributing to high strength.The TC4 layers,with their bimodal structure consisting of coarse and fine grains characterized by equiaxed and lamellar structures,experience more plastic strain than the TB8 layers.The hetero deformation associated with the detwinning ofαgrains in the TC4 layer induces toughening at high temperatures.展开更多
Ice load on underwater vehicles breaking through ice covers from underneath is a significant concern for researchers in polar exploration,and the research on this problem is still in its early stages.Both mechanical e...Ice load on underwater vehicles breaking through ice covers from underneath is a significant concern for researchers in polar exploration,and the research on this problem is still in its early stages.Both mechanical experimental measurement and numerical simulation pose research challenges.This study focuses on the ice load of a cylinder structure breaking upward through the ice sheet form underneath in the Small Ice Model Basin of China Ship Scientific Research Center(CSSRC SIMB).A high-speed camera system was employed to observe the ice sheet failure during the tests,in which,with the loading position as center,local radial cracks and circumferential cracks were generated.A load sensor was used to measure the overall ice load during this process.Meanwhile,a numerical model was developed using LS-DYNA for validation and comparison.With this model,numerical simulation was conducted under various ice thicknesses and upgoing speeds to analyze the instantaneous curves of ice load.The calculation results were statistically analyzed under different working conditions to determine the influence of the factors on the ice load of the cylinder.The study explores the measurement method about ice load of objects vertically breaking through model ice sheet and is expected to provide some fundamental insights into the safety design of underwater structures operating in ice waters.展开更多
Mooring cable tension is a crucial parameter for evaluating the safety and reliability of a floating platform mooring system.The real-time mooring tension in an actual marine environment has always been essential data...Mooring cable tension is a crucial parameter for evaluating the safety and reliability of a floating platform mooring system.The real-time mooring tension in an actual marine environment has always been essential data that mooring system designers aim to acquire.To address the need for long-term continuous monitoring of mooring tension in deep-sea marine environments,this paper presents a mooring cable tension monitoring method based on the principle of direct mechanical measurement.The developed tension monitoring sensors were installed and applied in the mooring system of the"Yongle"scientific experimental platform.Over the course of one year,a substantial amount of in-situ tension monitoring data was obtained.Under wave heights of up to 1.24 m,the mooring tension on the floating platform reached 16.5 tons.Through frequency domain and time domain analysis,the spectral characteristics of mooring tension,including waveinduced force,slow drift force,and mooring cable elastic restoring force,were determined.The mooring cable elastic restoring force frequency was approximately half of that of the wave signal.Due to the characteristics of the hinge connection structure of the dual module floating platform,under some specific working conditions the wave-induced force was the maximum of the three different frequency forces,and restoring force was the smallest.展开更多
The incidence and mortality rate of lung cancer rank among the highest worldwide,severely endangering human health and life.Metformin,an anti-diabetes drug,has been shown to elicit anticancer activities in various tum...The incidence and mortality rate of lung cancer rank among the highest worldwide,severely endangering human health and life.Metformin,an anti-diabetes drug,has been shown to elicit anticancer activities in various tumors.However,its underlying mechanisms remain elusive.In this work,we explore the role of receptor-interacting protein 1(RIP1)which plays a crucial role in the process of cell death,in metformin-induced anticancer activities in lung cancer.Metformin inhibits lung cancer cell proliferation in a dose-dependent manner and promotes apoptotic cell death,as evidenced by metformin-induced PARP and caspase cleavage.Furthermore,the pan-caspase inhibitor z-VAD-fmk reverses metformin-induced cell death.Western blot and qPCR results suggest that metformin markedly downregulates RIP1 expression without affecting its mRNA and ubiquitination levels(0 vs 80 mmol/L,100%vs 20%,100%vs 15%).Additionally,co-immunoprecipitation and immunofluorescence results reveal that metformin may suppress RIP1 expression in an Hsp70-dependent manner,as metformin promotes Hsp70 degradation,and Hsp70 endogenously interacts with RIP1.Subsequent CCK-8,flow cytometry,and Western blot analyses suggest that metformin decreases Hsp70/RIP1 expression through AMPK/PKA/GSK-3βaxis.Consistently,results from a subcutaneous transplant tumor model indicate that metformin retards tumor growth without affecting mouse body weight.Collectively,these data highlight the part of RIP1 in metformin-induced anticancer activities in lung cancer in vitro and in vivo,providing novel strategy for lung cancer administration.展开更多
As a typical steel,the fatigue of marine high-strength steels has been emphasized by scholars.In this paper,the fatigue performance and crack growth mechanism of a high-strength steel for ships are investigated by exp...As a typical steel,the fatigue of marine high-strength steels has been emphasized by scholars.In this paper,the fatigue performance and crack growth mechanism of a high-strength steel for ships are investigated by experimental methods.First,the fatigue threshold test and fatigue crack growth rate test of this high-strength steel under different stress ratios were carried out.The influence of stress ratio on the fatigue properties of this steel was analyzed.Secondly,scanning electron microscope was used to analyze the crack growth specimen section of this steel.The crack growth and failure mechanism of this steel were revealed.Finally,based on the above research results,the stress ratio effect of high-strength steel was investigated from the perspectives of crack closure and driving force.Considering the fatigue behavior in the near-threshold stage and the destabilization stage,a fatigue crack growth behavior prediction model of highstrength steel was established.The accuracy of the model was verified by test data.Moreover,the applicability of the modified model to various materials and its excellent predictive ability were verified through comparison with literature data and existing models.展开更多
Humans have always engaged with their surroundings and the ecology in which they live.However,during the industrial age,this contact has been more intense and has had a substantial impact on environment and ecosystems...Humans have always engaged with their surroundings and the ecology in which they live.However,during the industrial age,this contact has been more intense and has had a substantial impact on environment and ecosystems.For example,overexploitation of natural resources,mining,pollution,and deforestation are all elements that negatively affect biodiversity and natural resources.Few studies have been conducted to evaluate the damage caused,despite the significant uncontrolled pressure from human activity.However,maintaining its environment is essential to the survival of coastal fishing.Goal:This study’s goal was to evaluate how human activity affected Tabounsou’s coastal ecology in order to suggest remedial actions for sustainable management.The following was the methodological approach used:executive consultation and archival analysis;stakeholder survey(locals,farmers,salt producers,fishers,and loggers);inventory of species;anthropogenic activity inventory;evaluation of how human activity affects aquatic life in the research region;suggestion and action for sustainable management;Outcome:Executive consultation indicated that the main issues are:construction projects that reduce the estuary’s surface area;agricultural practices such as woodcutting and salt farming;the rise in resource exploitation;noncompliance with fisheries laws;and the catching of young fish.Eighty-three percent of fisherman ditch their nets on the coast after using them,but only seventeen percent burn them.With a 75%frequency rate,the same survey indicates that most fisherman fish around the coast.In the Tabounsou area,according to loggers’survey,68%of the wood cut is Rhizophora,24%is Avicennia,and 8%is Laguncularia.Three fish stocks,representing nine families and nine species,were identified by the species inventory.At 18%and 15%,respectively,the actors most frequently capture the species Pseudotolithus elongatus and Arius parkii.According to a poll of 30 farmers,90%of them apply fertilizer to their soil,while only 10%do not.During the dry season,salt is grown.According to two actors,Bougna Toro Toro produces 100 kg of salt per day,followed by Khoumawadé,which produces 80 kg,and Toumbibougni,which produces 70 kg.展开更多
The role of the adhesive layer in the ballistic performance of ceramic multi-layer armour system is complex and multi-faceted,often with trade-offs between single-and multi-hit performance.However,research focused on ...The role of the adhesive layer in the ballistic performance of ceramic multi-layer armour system is complex and multi-faceted,often with trade-offs between single-and multi-hit performance.However,research focused on untangling the underlying impact of varying adhesive cohesive or adhesion properties is limited and sometimes appears to provide conflicting conclusions.Comparison between the available studies is also often difficult due to variations in armour systems or ballistic testing being conducted.This review scrutinises the available research,identifying six critical properties of an adhesive layer in determining ballistic performance:elastic modulus,fracture strain,acoustic impedance,tensile bond strength,shear bond strength,and thickness.The impact of each of these properties on ballistic performance is discussed in detail,with clear description of the underlying processes involved,allowing clear optimisation goals to be established depending on the ceramic armour specification.展开更多
The Yemaomian landslide,the largest near-dam accumulation landslide in the Three Gorges Reservoir area,is situated 17 km upstream of the Three Gorges Dam.Nearly 20 years of monitoring data indicate that the landslide ...The Yemaomian landslide,the largest near-dam accumulation landslide in the Three Gorges Reservoir area,is situated 17 km upstream of the Three Gorges Dam.Nearly 20 years of monitoring data indicate that the landslide has been undergoing slow deformation with a low deformation rate and magnitude.This paper applies a stepwise linear regression method and a mechanical model of hydrodynamics triggering to deeply explore the relationship between geological conditions,external factors,and deformation characteristics.Based on the stage transition characteristics of external triggering factors,the deformation evolution process of the landslide since the reservoir impoundment is divided into three stages:(1)June 2003-September 2006,the landslide was reactivated by the significant rise in reservoir water levels,in a retrogressive mode;(2)October 2006-September 2018,the deformation mode shifted from retrogressive mode to creep deformation as a whole,primarily due to the degradation effect on the landslide mass caused by immersion in reservoir water.(3)October 2018-February 2024,a further significant reduction in the overall deformation rate and the impact of seasonal rainfall on landslide deformation surpassed that of reservoir water level fluctuations.The main component of landslide deformation is convergent creep,and extreme rainfall will be an important triggering factor for the local instability.Identifying the deformation evolution stages and determining the dominant external influencing factors at each stage is crucial for landslide research,and this paper provides an effective research paradigm for this purpose.展开更多
This paper focuses on how technology services can help small and medium-sized enterprises(SMEs)overcome the digital transformation dilemma of“cannot transform(lack of know-how),dare not transform(fear of risk),and ha...This paper focuses on how technology services can help small and medium-sized enterprises(SMEs)overcome the digital transformation dilemma of“cannot transform(lack of know-how),dare not transform(fear of risk),and have no money to transform(lack of funds).”Using literature analysis and multiple case comparisons,the study summarizes five major categories of technology services:technical support,consulting and planning,training and empowerment,resource integration,and financing connectivity.It constructs a“service–capability–performance”catalytic framework.Tracking of 58 enterprises in the Yangtze River Delta reveals that resource integration contributes the most to digital maturity,with absorptive capacity playing a significant mediating role;the configuration of“high technology services+high absorptive capacity+high environmental dynamism”is a sufficient condition for high transformation performance.Based on these findings,countermeasures are proposed,including improving the technology service system,strengthening government-industry-academia collaboration,and optimizing funding and talent supply,providing replicable experience for SMEs,governments,and technology service institutions.展开更多
Weizhou Island,located in Beihai,Guangxi Province,is recognized as the largest paleovolcanic island in China,characterized by its relatively young geological age.The development of island tourism has progressively est...Weizhou Island,located in Beihai,Guangxi Province,is recognized as the largest paleovolcanic island in China,characterized by its relatively young geological age.The development of island tourism has progressively established it as a significant tourist attraction within Beihai,transforming the area into a prominent leisure and tourism resort.As tourism on Weizhou Island continues to develop both in scope and in depth,it has increasingly influenced the sense of gain among the local community residents.Currently,in alignment with the strategic objective of achieving common prosperity,it is crucial to comprehend and enhance the sense of gain experienced by residents in island tourism destinations,as this is vital for the achievement of this overarching goal.Taking the residents of Weizhou Island in Beihai as the subjects,this paper constructs their sense of gain related to tourism,employing grounded theory.It posits that the residents’sense of gain comprises four primary dimensions:sense of economic gain,sense of social gain,sense of cultural gain,and sense of environmental gain.Additionally,the paper examines the factors that influence these dimensions.Based on this foundation,effective strategies are proposed to enhance the sense of gain among community residents in island tourism destinations,thereby promoting the sustainable development of island tourism.展开更多
Gassy soils are distributed in relatively shallow layers the Quaternary deposit in Hangzhou Bay area. The shallow gassy soils significantly affect the construction of underground projects. Proper characterization of s...Gassy soils are distributed in relatively shallow layers the Quaternary deposit in Hangzhou Bay area. The shallow gassy soils significantly affect the construction of underground projects. Proper characterization of spatial distribution of shallow gassy soils is indispensable prior to construction of underground projects in the area. Due to the costly conditions required in the site investigation for gassy soils, only a limited number of gas pressure data can be obtained in engineering practice, which leads to the uncertainty in characterizing spatial distribution of gassy soils. Determining the number of boreholes for investigating gassy soils and their corresponding locations is pivotal to reducing construction risk induced by gassy soils. However, this primarily relies on the engineering experience in the current site investigation practice. This study develops a probabilistic site investigation optimization method for planning investigation schemes (including the number and locations of boreholes) of gassy soils based on the conditional random field and Monte Carlo simulation. The proposed method aims to provide an optimal investigation scheme before the site investigation based on prior knowledge. Finally, the proposed approach is illustrated using a case study.展开更多
During strong unsteady flow processes such as cavitation initiation and collapse,the volume changes generated by the materials transformation of cavitation phase transition seriously lag behind the volume evolution fo...During strong unsteady flow processes such as cavitation initiation and collapse,the volume changes generated by the materials transformation of cavitation phase transition seriously lag behind the volume evolution formed by the flow process.The phase transition and hydrodynamics are in a non-equilibrium state.A cavitation model that can describe such non-equilibrium phenomena is needed in numerical simulations of cavitation flow.The paper starts from the molecular dynamics’principle of phase change of matter,and based on the Maxwell velocity distribution form of molecular thermal motion,elaborates on the formation process of Hertz Knudsen formula for material exchange at the interface between liquid and vapor.On this basis,using the evolution equation of gas nucleus number density in water and the compressible state equation of vapor,a non-equilibrium cavitation model for phase transition and hydrodynamics is established.The simulation results of a vapor bubble collapse process in the non-equilibrium cavitation model show different behavior from the simulation results of the equilibrium cavitation model.The simulation results of the equilibrium cavitation model show that the vapor bubble collapses once and completely disappear,while the simulation results of the non-equilibrium cavitation model show multiple collapses and rebound,which is agreement with the experimental results of the vapor bubble collapse.展开更多
Chronic hepatitis B virus(HBV)infection remains a major health burden worldwide.To establish a persistence infection,HBV needs to evade both adaptive and innate immune surveillance.Multiple mechanisms for adaptive imm...Chronic hepatitis B virus(HBV)infection remains a major health burden worldwide.To establish a persistence infection,HBV needs to evade both adaptive and innate immune surveillance.Multiple mechanisms for adaptive immunity evasion have been established,but how HBV evades the innate surveillance is less clear.There are three types of host cells involving in the innate immune responses against HBV infection:Hepatocytes,hepatic nonparenchymal cells and conventional innate immune cells.Among these,hepatocytes are the only target cells that are susceptible to HBV infection and the only confirmed site where HBV replication takes place.This review focuses on the hepatocyte-intrinsic innate immunity;one of the earliest host defense responses.After entering hepatocytes,the viral components can be sensed by the cellular pattern recognition receptors.This triggers downstream antiviral responses capable of inhibiting viral replication and even degrading the viral DNA genome directly or indirectly.However,HBV has evolved a variety of sophisticated strategies to evade intracellular immune defense,resulting in the establishment of infection.Here,we provide insights into the mechanisms of the intrinsic innate immune response of hepatocytes and how HBV escapes these defense mechanisms.Hopefully,this will lay the foundation for the development of novel anti-HBV therapies.展开更多
The potential application of Huangqi(Astragali Radix)in the treatment of diabetes mellitus(DM)has garnered increasing attention.β-cell dysfunction is one of the core mechanisms in the pathogenesis of DM and effective...The potential application of Huangqi(Astragali Radix)in the treatment of diabetes mellitus(DM)has garnered increasing attention.β-cell dysfunction is one of the core mechanisms in the pathogenesis of DM and effectively protecting and restoring pancreaticβ-cell function remains a key challenge in DM prevention and treatment.Studies have shown that the active components of Huangqi(Astragali Radix)can alleviate glucolipotoxicity-inducedβ-cell damage by promoting glucose uptake mediated by glucose transporter 4(GLUT-4),inhibiting the Wnt1/β-catenin signaling pathway to reduce lipid deposition in liver and pancreatic tissues and upregulating peroxisome proliferator-activated receptorα(PPARα)gene expression.Additionally,Huangqi(Astragali Radix)can reduce cell apoptosis by mitigating endoplasmic reticulum stress,suppress pyroptosis via the NF-κB/NLRP3/TXNIP signaling pathway,and inhibit ferroptosis and autophagy to decreaseβ-cell death.Furthermore,Huangqi(Astragali Radix)can promoteβ-cell proliferation by modulating dedifferentiation and transdifferentiation,improve the islet microenvironment by regulating immune function and reducing M1 macrophage polarization,and may delayβ-cell senescence.This review summarizes the research progress of active ingredients in Huangqi(Astragali Radix)in protecting pancreaticβ-cell,which provides new insights and a scientific basis for its future application in DM prevention and treatment.展开更多
基金research was funded by Science and Technology Project of State Grid Corporation of China under grant number 5200-202319382A-2-3-XG.
文摘Iced transmission line galloping poses a significant threat to the safety and reliability of power systems,leading directly to line tripping,disconnections,and power outages.Existing early warning methods of iced transmission line galloping suffer from issues such as reliance on a single data source,neglect of irregular time series,and lack of attention-based closed-loop feedback,resulting in high rates of missed and false alarms.To address these challenges,we propose an Internet of Things(IoT)empowered early warning method of transmission line galloping that integrates time series data from optical fiber sensing and weather forecast.Initially,the method applies a primary adaptive weighted fusion to the IoT empowered optical fiber real-time sensing data and weather forecast data,followed by a secondary fusion based on a Back Propagation(BP)neural network,and uses the K-medoids algorithm for clustering the fused data.Furthermore,an adaptive irregular time series perception adjustment module is introduced into the traditional Gated Recurrent Unit(GRU)network,and closed-loop feedback based on attentionmechanism is employed to update network parameters through gradient feedback of the loss function,enabling closed-loop training and time series data prediction of the GRU network model.Subsequently,considering various types of prediction data and the duration of icing,an iced transmission line galloping risk coefficient is established,and warnings are categorized based on this coefficient.Finally,using an IoT-driven realistic dataset of iced transmission line galloping,the effectiveness of the proposed method is validated through multi-dimensional simulation scenarios.
基金supported by the Postgraduate Research&Practice Innovation Program of Jiangsu Province(Grant No.KYCX24_0714).
文摘To examine the similarities and differences in the evolution of cavity,wetting and dynamics of a highspeed,oblique water-entry projectile with different positive angles of attack,a comparative analysis has been conducted based on the numerical results of two mathematical models,the rigid-body model and fluid-structure interaction model.In addition,the applicable scope of the above two methods,and the structural response characteristics of the projectile have also been investigated.Our results demonstrate that:(1) The impact loads and angular motion of the projectile of the rigid-body method are more likely to exhibit periodic variations due to the periodic tail slap,its range of positive angles of attack is about α<2°.(2) When the projectile undergone significant wetting,a strong coupling effect is observed among wetting,structural deformation,and projectile motion.With the applied projectile shape,it is observed that,when the projectile bends,the final wetting position is that of Part B(cylinder of body).With the occu rrence of this phenomenon,the projectile ballistics beco me completely unstable.(3) The force exerted on the lower surface of the projectile induced by wetting is the primary reason of the destabilization of the projectile traj ectory and structu ral deformation failure.Bending deformation is most likely to appear at the junction of Part C(cone of body) and Part D(tail).The safe angles of attack of the projectile stability are found to be about α≤2°.
文摘Colorectal cancer(CRC)is the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide.The leading risk factors for CRC include male gender,age over 50,family history,obesity,tobacco smoking,alco-hol consumption,and unhealthy diet.CRC screening methods vary considerably between countries and depend on incidence,economic resources and healthcare structure.Important aspects of screening include adherence,which can vary signi-ficantly across ethnic and socioeconomic groups.Basic concepts of CRC screening include pre-stratification of patients by identifying risk factors and then using fecal immunochemical test or guaiac-based fecal occult blood test and/or colono-scopy or radiologic imaging techniques.Technological capabilities for CRC scree-ning are rapidly evolving and include stool DNA test,liquid biopsy,virtual colo-nography,and the use of artificial intelligence.A CRC prevention strategy should be comprehensive and include active patient education along with targeted imple-mentation of screening.
基金supported by the National Natural Science Foundation of China(Nos.52172243,52371215)。
文摘All-solid-state Li batteries(ASSLBs)using solid electrolytes(SEs)have gained significant attention in recent years considering the safety issue and their high energy density.Despite these advantages,the commercialization of ASSLBs still faces challenges regarding the electrolyte/electrodes interfaces and growth of Li dendrites.Elemental doping is an effective and direct method to enhance the performance of SEs.Here,we report an Al-F co-doping strategy to improve the overall properties including ion conductivity,high voltage stability,and cathode and anode compatibility.Particularly,the Al-F co-doping enables the formation of a thin Li-Al alloy layer and fluoride interphases,thereby constructing a relatively stable interface and promoting uniform Li deposition.The similar merits of Al-F co-doping are also revealed in the Li-argyrodite series.ASSLBs assembled with these optimized electrolytes gain good electrochemical performance,demonstrating the universality of Al-F co-doping towards advanced SEs.
基金support provided by National Key Research and Development Program of China(2023YFE0203000 and 2016YFC0300200)the NSAF(Grant No.U2330205)+3 种基金Full-Sea-Depth Battery Project(2020-XXXX-XX-246-00)Open project of Shaanxi Laboratory of Aerospace Power(2022ZY2-JCYJ-01-09)Fundamental Research Funds for the Central Universities,ND Basic Research Funds(G2022WD)the Innovation Team of Shaanxi Province。
文摘The operation of deep-sea underwater vehicles relies entirely on onboard batteries.However,the extreme deep-sea conditions,characterized by ultrahigh hydraulic pressure,low temperature,and seawater conductivity,pose significant challenges for battery development.These conditions drive the need for specialized designs in deep-sea batteries,incorporating critical aspects of power generation,protection,distribution,and management.Over time,deep-sea battery technology has evolved through multiple generations,with lithium(Li)batteries emerging in recent decades as the preferred power source due to their high energy and reduced operational risks.Although the rapid progress of Li batteries has notably advanced the capabilities of underwater vehicles,critical technical issues remain unresolved.This review first systematically presents the whole picture of deep-sea battery manufacturing,focusing on Li batteries as the current mainstream solution for underwater power.It examines the key aspects of deep-sea Li battery development,including materials selection informed by electro-chemo-mechanics models,component modification and testing,and battery management systems specialized in software and hardware.Finally,it discusses the main challenges limiting the utilization of deep-sea batteries and outlines promising directions for future development.Based on the systematic reflection on deep-sea batteries and discussion on deep-sea Li batteries,this review aims to provide a research foundation for developing underwater power tailored for extreme environmental exploration.
基金supported by the National Natural Science Foundation of China(31970447)starting fund for doctoral research of Lishui University(6004LMM01Z)the Special Funds for Scientific Research of Postdoctoral Work Station Assessment in Zhejiang Province,China(2023).
文摘Two new species of the Aglaostigma laticinctum subgroup belonging to A.tertium group,are described and illustrated in this study:A.leucogaster Liu,Li&Wei sp.nov.and A.rufitegula Liu,Li&Wei sp.nov.The Aglaostigma laticinctum subgroup is proposed here for the first time,with a brief discussion of its diagnostic features.Additionally,a key to all known species of the A.laticinctum subgroup from China is provided.
基金financially supported by the Natural Science Foundation of Changsha,China(No.kq2402015)the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIP)(Nos.NRF-2021R1A2C3006662 and NRF-2022R1A5A1030054)supported by Brain Pool Program through the NRF of Korea,funded by the Ministry of Science and ICT(No.NRF-RS_(2)02300263999)
文摘Lightweight,high-strength,and heat-resistant protective structures have consistently been crucial for applications in extreme environments,such as aerospace,semiconductors,and nuclear power industries.Multilayered TC4/TB8 titanium(Ti)laminates,inspired by theheterostructures of natural biological shells,were fabricated using a hybrid diffusion bonding-hot rolling process followed by an aging treatment,resulting in an architected micro structure.The laminate achieves an ultra-high yield stress of 1020 MPa and proper uniform elongation of 4.2%at 500℃.The TB8 layers with high-density nano-precipitates and dislocations act as hard zone,contributing to high strength.The TC4 layers,with their bimodal structure consisting of coarse and fine grains characterized by equiaxed and lamellar structures,experience more plastic strain than the TB8 layers.The hetero deformation associated with the detwinning ofαgrains in the TC4 layer induces toughening at high temperatures.
文摘Ice load on underwater vehicles breaking through ice covers from underneath is a significant concern for researchers in polar exploration,and the research on this problem is still in its early stages.Both mechanical experimental measurement and numerical simulation pose research challenges.This study focuses on the ice load of a cylinder structure breaking upward through the ice sheet form underneath in the Small Ice Model Basin of China Ship Scientific Research Center(CSSRC SIMB).A high-speed camera system was employed to observe the ice sheet failure during the tests,in which,with the loading position as center,local radial cracks and circumferential cracks were generated.A load sensor was used to measure the overall ice load during this process.Meanwhile,a numerical model was developed using LS-DYNA for validation and comparison.With this model,numerical simulation was conducted under various ice thicknesses and upgoing speeds to analyze the instantaneous curves of ice load.The calculation results were statistically analyzed under different working conditions to determine the influence of the factors on the ice load of the cylinder.The study explores the measurement method about ice load of objects vertically breaking through model ice sheet and is expected to provide some fundamental insights into the safety design of underwater structures operating in ice waters.
文摘Mooring cable tension is a crucial parameter for evaluating the safety and reliability of a floating platform mooring system.The real-time mooring tension in an actual marine environment has always been essential data that mooring system designers aim to acquire.To address the need for long-term continuous monitoring of mooring tension in deep-sea marine environments,this paper presents a mooring cable tension monitoring method based on the principle of direct mechanical measurement.The developed tension monitoring sensors were installed and applied in the mooring system of the"Yongle"scientific experimental platform.Over the course of one year,a substantial amount of in-situ tension monitoring data was obtained.Under wave heights of up to 1.24 m,the mooring tension on the floating platform reached 16.5 tons.Through frequency domain and time domain analysis,the spectral characteristics of mooring tension,including waveinduced force,slow drift force,and mooring cable elastic restoring force,were determined.The mooring cable elastic restoring force frequency was approximately half of that of the wave signal.Due to the characteristics of the hinge connection structure of the dual module floating platform,under some specific working conditions the wave-induced force was the maximum of the three different frequency forces,and restoring force was the smallest.
文摘The incidence and mortality rate of lung cancer rank among the highest worldwide,severely endangering human health and life.Metformin,an anti-diabetes drug,has been shown to elicit anticancer activities in various tumors.However,its underlying mechanisms remain elusive.In this work,we explore the role of receptor-interacting protein 1(RIP1)which plays a crucial role in the process of cell death,in metformin-induced anticancer activities in lung cancer.Metformin inhibits lung cancer cell proliferation in a dose-dependent manner and promotes apoptotic cell death,as evidenced by metformin-induced PARP and caspase cleavage.Furthermore,the pan-caspase inhibitor z-VAD-fmk reverses metformin-induced cell death.Western blot and qPCR results suggest that metformin markedly downregulates RIP1 expression without affecting its mRNA and ubiquitination levels(0 vs 80 mmol/L,100%vs 20%,100%vs 15%).Additionally,co-immunoprecipitation and immunofluorescence results reveal that metformin may suppress RIP1 expression in an Hsp70-dependent manner,as metformin promotes Hsp70 degradation,and Hsp70 endogenously interacts with RIP1.Subsequent CCK-8,flow cytometry,and Western blot analyses suggest that metformin decreases Hsp70/RIP1 expression through AMPK/PKA/GSK-3βaxis.Consistently,results from a subcutaneous transplant tumor model indicate that metformin retards tumor growth without affecting mouse body weight.Collectively,these data highlight the part of RIP1 in metformin-induced anticancer activities in lung cancer in vitro and in vivo,providing novel strategy for lung cancer administration.
文摘As a typical steel,the fatigue of marine high-strength steels has been emphasized by scholars.In this paper,the fatigue performance and crack growth mechanism of a high-strength steel for ships are investigated by experimental methods.First,the fatigue threshold test and fatigue crack growth rate test of this high-strength steel under different stress ratios were carried out.The influence of stress ratio on the fatigue properties of this steel was analyzed.Secondly,scanning electron microscope was used to analyze the crack growth specimen section of this steel.The crack growth and failure mechanism of this steel were revealed.Finally,based on the above research results,the stress ratio effect of high-strength steel was investigated from the perspectives of crack closure and driving force.Considering the fatigue behavior in the near-threshold stage and the destabilization stage,a fatigue crack growth behavior prediction model of highstrength steel was established.The accuracy of the model was verified by test data.Moreover,the applicability of the modified model to various materials and its excellent predictive ability were verified through comparison with literature data and existing models.
文摘Humans have always engaged with their surroundings and the ecology in which they live.However,during the industrial age,this contact has been more intense and has had a substantial impact on environment and ecosystems.For example,overexploitation of natural resources,mining,pollution,and deforestation are all elements that negatively affect biodiversity and natural resources.Few studies have been conducted to evaluate the damage caused,despite the significant uncontrolled pressure from human activity.However,maintaining its environment is essential to the survival of coastal fishing.Goal:This study’s goal was to evaluate how human activity affected Tabounsou’s coastal ecology in order to suggest remedial actions for sustainable management.The following was the methodological approach used:executive consultation and archival analysis;stakeholder survey(locals,farmers,salt producers,fishers,and loggers);inventory of species;anthropogenic activity inventory;evaluation of how human activity affects aquatic life in the research region;suggestion and action for sustainable management;Outcome:Executive consultation indicated that the main issues are:construction projects that reduce the estuary’s surface area;agricultural practices such as woodcutting and salt farming;the rise in resource exploitation;noncompliance with fisheries laws;and the catching of young fish.Eighty-three percent of fisherman ditch their nets on the coast after using them,but only seventeen percent burn them.With a 75%frequency rate,the same survey indicates that most fisherman fish around the coast.In the Tabounsou area,according to loggers’survey,68%of the wood cut is Rhizophora,24%is Avicennia,and 8%is Laguncularia.Three fish stocks,representing nine families and nine species,were identified by the species inventory.At 18%and 15%,respectively,the actors most frequently capture the species Pseudotolithus elongatus and Arius parkii.According to a poll of 30 farmers,90%of them apply fertilizer to their soil,while only 10%do not.During the dry season,salt is grown.According to two actors,Bougna Toro Toro produces 100 kg of salt per day,followed by Khoumawadé,which produces 80 kg,and Toumbibougni,which produces 70 kg.
基金funding for this research was provided by Netherlands Ministry of Defence
文摘The role of the adhesive layer in the ballistic performance of ceramic multi-layer armour system is complex and multi-faceted,often with trade-offs between single-and multi-hit performance.However,research focused on untangling the underlying impact of varying adhesive cohesive or adhesion properties is limited and sometimes appears to provide conflicting conclusions.Comparison between the available studies is also often difficult due to variations in armour systems or ballistic testing being conducted.This review scrutinises the available research,identifying six critical properties of an adhesive layer in determining ballistic performance:elastic modulus,fracture strain,acoustic impedance,tensile bond strength,shear bond strength,and thickness.The impact of each of these properties on ballistic performance is discussed in detail,with clear description of the underlying processes involved,allowing clear optimisation goals to be established depending on the ceramic armour specification.
基金supported by the National Natural Science Foundation of China(Nos.U2340226,12072047,42277186)China Three Gorges Corporation under the contract of No.0799291(SXSN/5115)the Fundamental Research Funds for Central Public Welfare Research Institutes(CKSF20241014/YT,CKSF20241016/YT).
文摘The Yemaomian landslide,the largest near-dam accumulation landslide in the Three Gorges Reservoir area,is situated 17 km upstream of the Three Gorges Dam.Nearly 20 years of monitoring data indicate that the landslide has been undergoing slow deformation with a low deformation rate and magnitude.This paper applies a stepwise linear regression method and a mechanical model of hydrodynamics triggering to deeply explore the relationship between geological conditions,external factors,and deformation characteristics.Based on the stage transition characteristics of external triggering factors,the deformation evolution process of the landslide since the reservoir impoundment is divided into three stages:(1)June 2003-September 2006,the landslide was reactivated by the significant rise in reservoir water levels,in a retrogressive mode;(2)October 2006-September 2018,the deformation mode shifted from retrogressive mode to creep deformation as a whole,primarily due to the degradation effect on the landslide mass caused by immersion in reservoir water.(3)October 2018-February 2024,a further significant reduction in the overall deformation rate and the impact of seasonal rainfall on landslide deformation surpassed that of reservoir water level fluctuations.The main component of landslide deformation is convergent creep,and extreme rainfall will be an important triggering factor for the local instability.Identifying the deformation evolution stages and determining the dominant external influencing factors at each stage is crucial for landslide research,and this paper provides an effective research paradigm for this purpose.
基金supported by Anhui Provincial Philosophy&Social Science Fund(AHSKY2023D12)Anqing Normal University Key Project Grant“Research on the Digital Interactive Development of Trade between China Railway Express and Countries along the Belt and Road Initiative”(SK202211ZD)。
文摘This paper focuses on how technology services can help small and medium-sized enterprises(SMEs)overcome the digital transformation dilemma of“cannot transform(lack of know-how),dare not transform(fear of risk),and have no money to transform(lack of funds).”Using literature analysis and multiple case comparisons,the study summarizes five major categories of technology services:technical support,consulting and planning,training and empowerment,resource integration,and financing connectivity.It constructs a“service–capability–performance”catalytic framework.Tracking of 58 enterprises in the Yangtze River Delta reveals that resource integration contributes the most to digital maturity,with absorptive capacity playing a significant mediating role;the configuration of“high technology services+high absorptive capacity+high environmental dynamism”is a sufficient condition for high transformation performance.Based on these findings,countermeasures are proposed,including improving the technology service system,strengthening government-industry-academia collaboration,and optimizing funding and talent supply,providing replicable experience for SMEs,governments,and technology service institutions.
基金Sponsored by the Guangxi Philosophy and Social Sciences Research Annual Project(2024GLF036)Thousands of Young and Middle-aged Backbone Teachers Cultivation Program for Universities and Colleges in Guangxi(2021QGRW061).
文摘Weizhou Island,located in Beihai,Guangxi Province,is recognized as the largest paleovolcanic island in China,characterized by its relatively young geological age.The development of island tourism has progressively established it as a significant tourist attraction within Beihai,transforming the area into a prominent leisure and tourism resort.As tourism on Weizhou Island continues to develop both in scope and in depth,it has increasingly influenced the sense of gain among the local community residents.Currently,in alignment with the strategic objective of achieving common prosperity,it is crucial to comprehend and enhance the sense of gain experienced by residents in island tourism destinations,as this is vital for the achievement of this overarching goal.Taking the residents of Weizhou Island in Beihai as the subjects,this paper constructs their sense of gain related to tourism,employing grounded theory.It posits that the residents’sense of gain comprises four primary dimensions:sense of economic gain,sense of social gain,sense of cultural gain,and sense of environmental gain.Additionally,the paper examines the factors that influence these dimensions.Based on this foundation,effective strategies are proposed to enhance the sense of gain among community residents in island tourism destinations,thereby promoting the sustainable development of island tourism.
文摘Gassy soils are distributed in relatively shallow layers the Quaternary deposit in Hangzhou Bay area. The shallow gassy soils significantly affect the construction of underground projects. Proper characterization of spatial distribution of shallow gassy soils is indispensable prior to construction of underground projects in the area. Due to the costly conditions required in the site investigation for gassy soils, only a limited number of gas pressure data can be obtained in engineering practice, which leads to the uncertainty in characterizing spatial distribution of gassy soils. Determining the number of boreholes for investigating gassy soils and their corresponding locations is pivotal to reducing construction risk induced by gassy soils. However, this primarily relies on the engineering experience in the current site investigation practice. This study develops a probabilistic site investigation optimization method for planning investigation schemes (including the number and locations of boreholes) of gassy soils based on the conditional random field and Monte Carlo simulation. The proposed method aims to provide an optimal investigation scheme before the site investigation based on prior knowledge. Finally, the proposed approach is illustrated using a case study.
文摘During strong unsteady flow processes such as cavitation initiation and collapse,the volume changes generated by the materials transformation of cavitation phase transition seriously lag behind the volume evolution formed by the flow process.The phase transition and hydrodynamics are in a non-equilibrium state.A cavitation model that can describe such non-equilibrium phenomena is needed in numerical simulations of cavitation flow.The paper starts from the molecular dynamics’principle of phase change of matter,and based on the Maxwell velocity distribution form of molecular thermal motion,elaborates on the formation process of Hertz Knudsen formula for material exchange at the interface between liquid and vapor.On this basis,using the evolution equation of gas nucleus number density in water and the compressible state equation of vapor,a non-equilibrium cavitation model for phase transition and hydrodynamics is established.The simulation results of a vapor bubble collapse process in the non-equilibrium cavitation model show different behavior from the simulation results of the equilibrium cavitation model.The simulation results of the equilibrium cavitation model show that the vapor bubble collapses once and completely disappear,while the simulation results of the non-equilibrium cavitation model show multiple collapses and rebound,which is agreement with the experimental results of the vapor bubble collapse.
基金Supported by Shenzhen Medical Research Fund,No.D2301010Shenzhen Science and Technology Program,No.RCYX20231211090346060。
文摘Chronic hepatitis B virus(HBV)infection remains a major health burden worldwide.To establish a persistence infection,HBV needs to evade both adaptive and innate immune surveillance.Multiple mechanisms for adaptive immunity evasion have been established,but how HBV evades the innate surveillance is less clear.There are three types of host cells involving in the innate immune responses against HBV infection:Hepatocytes,hepatic nonparenchymal cells and conventional innate immune cells.Among these,hepatocytes are the only target cells that are susceptible to HBV infection and the only confirmed site where HBV replication takes place.This review focuses on the hepatocyte-intrinsic innate immunity;one of the earliest host defense responses.After entering hepatocytes,the viral components can be sensed by the cellular pattern recognition receptors.This triggers downstream antiviral responses capable of inhibiting viral replication and even degrading the viral DNA genome directly or indirectly.However,HBV has evolved a variety of sophisticated strategies to evade intracellular immune defense,resulting in the establishment of infection.Here,we provide insights into the mechanisms of the intrinsic innate immune response of hepatocytes and how HBV escapes these defense mechanisms.Hopefully,this will lay the foundation for the development of novel anti-HBV therapies.
基金supported by National Natural Science Foundation of China(81774304)Shaanxi Traditional Chinese Medicine Administration Research Project(SZYKJCYC-2025-JC-016)+1 种基金Qinchuangyuan Traditional Chinese Medicine Industrial Innovation Cluster Project(L2024-QCY-ZYYJJQ-X85)Xianyang Science and Technology Bureau Key R&D Program(L2022ZDYFSF003)。
文摘The potential application of Huangqi(Astragali Radix)in the treatment of diabetes mellitus(DM)has garnered increasing attention.β-cell dysfunction is one of the core mechanisms in the pathogenesis of DM and effectively protecting and restoring pancreaticβ-cell function remains a key challenge in DM prevention and treatment.Studies have shown that the active components of Huangqi(Astragali Radix)can alleviate glucolipotoxicity-inducedβ-cell damage by promoting glucose uptake mediated by glucose transporter 4(GLUT-4),inhibiting the Wnt1/β-catenin signaling pathway to reduce lipid deposition in liver and pancreatic tissues and upregulating peroxisome proliferator-activated receptorα(PPARα)gene expression.Additionally,Huangqi(Astragali Radix)can reduce cell apoptosis by mitigating endoplasmic reticulum stress,suppress pyroptosis via the NF-κB/NLRP3/TXNIP signaling pathway,and inhibit ferroptosis and autophagy to decreaseβ-cell death.Furthermore,Huangqi(Astragali Radix)can promoteβ-cell proliferation by modulating dedifferentiation and transdifferentiation,improve the islet microenvironment by regulating immune function and reducing M1 macrophage polarization,and may delayβ-cell senescence.This review summarizes the research progress of active ingredients in Huangqi(Astragali Radix)in protecting pancreaticβ-cell,which provides new insights and a scientific basis for its future application in DM prevention and treatment.
