BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for r...BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment plans.AIM To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent aggression.METHODS Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were identified.Network pharmacology was used to establish protein-protein interaction networks of the core targets of olanzapine.Gene Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently performed.RESULTS Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis pathways.After treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with schizophrenia.Olanzapine effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis pathways.Ten core targets of olanzapine were involved in several key pathways.CONCLUSION The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.展开更多
Background and Objectives:Mechanism studies have indicated that magnesium(Mg)and calcium(Ca)have important biological functions in glucose regulation,but epidemiological data on their associations with glycosyl ated h...Background and Objectives:Mechanism studies have indicated that magnesium(Mg)and calcium(Ca)have important biological functions in glucose regulation,but epidemiological data on their associations with glycosyl ated hemoglobin(HbA1c)are sparse.We aimed to explore the associations of Mg and Ca with abnormal HbA1c,and examine the mediating effects of inflammation in coronary artery disease(CAD)Chinese adults.Methods and Study Design:A hospital-based cross-sectional study of 11934 patients with CAD was conducted.Serum Mg and Ca concentrations were measured.Results:In multivariable analyses,Mg and Mg/Ca ratio were inverse ly associated with abnormal HbA1c(Q4 vs Q1:ORMg:0.61,95%CIMg:0.53,0.71;ORMg/Ca ratio:0.67,95%CIMg/Ca ratio:0.54,0.84).However,null association of Ca with abnormal HbA1c was shown(Q4 vs Q1:OR:1.15,95%CI:0.92,1.44).Serum Mg and Mg/Ca ratio were inversely associated with abnormal fasting blood glucose(FBG).In contrast,serum Ca was positively associated with abnormal FBG.Path analysis indicated that there were no mediating effects of hypersensitivity C reactive protein(hsCRP)on Mg and Mg/Ca-abnormal HbA1c as sociations.Conclusions:Our study suggested that serum Mg and Mg/Ca ratio were inversely associated with ab normal HbA1c in Chinese adults with CAD.The Mg-abnormal HbA1c relationship might not be mediated by hsCRP.展开更多
基金Supported by Henan Provincial Science and Technology Research Project,No.242102310203.
文摘BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment plans.AIM To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent aggression.METHODS Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were identified.Network pharmacology was used to establish protein-protein interaction networks of the core targets of olanzapine.Gene Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently performed.RESULTS Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis pathways.After treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with schizophrenia.Olanzapine effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis pathways.Ten core targets of olanzapine were involved in several key pathways.CONCLUSION The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.
基金supported by the Talent Project of Nan tong Maternal and Child Health Hospital(No.YYR202005).
文摘Background and Objectives:Mechanism studies have indicated that magnesium(Mg)and calcium(Ca)have important biological functions in glucose regulation,but epidemiological data on their associations with glycosyl ated hemoglobin(HbA1c)are sparse.We aimed to explore the associations of Mg and Ca with abnormal HbA1c,and examine the mediating effects of inflammation in coronary artery disease(CAD)Chinese adults.Methods and Study Design:A hospital-based cross-sectional study of 11934 patients with CAD was conducted.Serum Mg and Ca concentrations were measured.Results:In multivariable analyses,Mg and Mg/Ca ratio were inverse ly associated with abnormal HbA1c(Q4 vs Q1:ORMg:0.61,95%CIMg:0.53,0.71;ORMg/Ca ratio:0.67,95%CIMg/Ca ratio:0.54,0.84).However,null association of Ca with abnormal HbA1c was shown(Q4 vs Q1:OR:1.15,95%CI:0.92,1.44).Serum Mg and Mg/Ca ratio were inversely associated with abnormal fasting blood glucose(FBG).In contrast,serum Ca was positively associated with abnormal FBG.Path analysis indicated that there were no mediating effects of hypersensitivity C reactive protein(hsCRP)on Mg and Mg/Ca-abnormal HbA1c as sociations.Conclusions:Our study suggested that serum Mg and Mg/Ca ratio were inversely associated with ab normal HbA1c in Chinese adults with CAD.The Mg-abnormal HbA1c relationship might not be mediated by hsCRP.
