Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).T...Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).The United States Preventive Services Task Force(USPSTF) October 2015 draft recommendation for CRC screening included mt-s DNA as an "alternative" screening test that "may be useful in select clinical circumstances",despite its very high sensitivity for early stage CRC.The evidence supporting mt-s DNA for routine screening use is robust.The clinical efficacy of mt-s DNA as measured by sensitivity,specificity,life-years gained(LYG),and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document,especially those requiring annual testing adherence.In a population with primarily irregular screening participation,tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual adherence.This paper reviews the evidence supporting mt-s DNA for routine screening and demonstrates,using USPSTF's modeling data,that mt-s DNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing,high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening.展开更多
Electrical conductivity(EC)is considered as the most important indicator for assessment of groundwater quality.Determination of suitable interpolation method for derivation of groundwater quality variables map such as...Electrical conductivity(EC)is considered as the most important indicator for assessment of groundwater quality.Determination of suitable interpolation method for derivation of groundwater quality variables map such as EC is dependent on region conditions and existence of enough data.For determining groundwater EC,341 groundwater samples were randomly collected from the central regions of Guilan province,paddy soils,in northern Iran.Interpolation methods including inverse distance weighting(IDW),global polynomial interpolation(GPI),local polynomial interpolation(LPI),radial basis function(RBF),ordinary kriging(OK)and empirical Bayesian Kriging(EBK)were used to generate spatial distribution of groundwater EC.The results indicate that EBK is a superior method with the least RMSE,MAE and the highest R 2.The generated maps can be used to identify the regions in the studied area where groundwater could be allowed to be extracted and utilized by farmers to reduce adverse effect of the scarcity of surface water.展开更多
Ancestors of human species have been living on the planet earth for about six million years while the modern form of humans only evolved about 200,000 years ago. Civilization is only about 6000 years old, and industri...Ancestors of human species have been living on the planet earth for about six million years while the modern form of humans only evolved about 200,000 years ago. Civilization is only about 6000 years old, and industrialization started in the 1800s. World population interconnectedness is enhanced with love and mercy but disrupted with dishonest, lies and wars. Human species has been feeding on animal fat as the finest and prime source of energy for all human history. In 1953 Ancel Keys and collaborates illusionized human kind that their historical source of energy is toxic. Massive health, behavioral as well as economic consequences followed. Human hearts known historically to be the seat of spirit, soul and emotions is proven by our group to orchestrate with global energetic fields. Global consciousness as represented by the planetary electromagnetic fields is in critical need to be feed with awakening merciful information. Documents refuting Ancek Keys dogma and reverting humanity to the truth in their energy source is presented in this review. The harmony we expect is not only physiological but will affect our global planetary environment for the wellbeing of human species in earth.展开更多
2016 is the International Year of Global Understanding(IYGU).The IYGU declared by the three leading global sciences organizations of the natural,social,and human sciences recognizes that global social,cultural and cli...2016 is the International Year of Global Understanding(IYGU).The IYGU declared by the three leading global sciences organizations of the natural,social,and human sciences recognizes that global social,cultural and climate changes require a global level of understanding.In this paper the basic IYGU guidelines are discussed,as well as the goals and action areas of this ambitious initiative.展开更多
Objective： To develop a health-evaluating scale from a Chinese medicine（CM） perspective and reflecting CM conception of health. Methods： The Traditional Chinese Medicine Health Self-Evaluation Scale（TCM-50） was ...Objective： To develop a health-evaluating scale from a Chinese medicine（CM） perspective and reflecting CM conception of health. Methods： The Traditional Chinese Medicine Health Self-Evaluation Scale（TCM-50） was developed by verification of dimensions, formation of item pool, verification of scoring methodology, and pilot test of scale and item analysis. Results： TCM-50 composed of 50 items that could be classified into 4 dimensions including physiology and health, psychology and health, nature and health, and society and health. An examination of reliability and validity of TCM-50 yielded Cronbach＇s α coefficient of 0.927, and half coefficient of r was 0.876. The intraclass correlation coefficient of total score was 0.912. After using SF-36 questionnaire to evaluate the criterion validity, the Pearson r of the score of the two scales from the same participant was 0.740. Conclusions： TCM-50 has good reliability and validity, and can yield similar levels of efficacy as SF-36 in terms of evaluating people＇s overall health level. As a scale based on CM theory, TCM-50 is suitable for self-measuring the general health of Chinese patients.展开更多
Objective:To test the effect of supplementation of Thymus vulgaris L.(T.vulgaris)or Glycyrrhizaglabra(G.glabra)in corn-soybean meal diets as well as the inclusion of an exogenous enzyme i.e.Combo^(®)in barley-soy...Objective:To test the effect of supplementation of Thymus vulgaris L.(T.vulgaris)or Glycyrrhizaglabra(G.glabra)in corn-soybean meal diets as well as the inclusion of an exogenous enzyme i.e.Combo^(®)in barley-soybean meal diets together with mentioned medicinal plants in broiler diets.Methods:A total of 270 unsexed 1-day-old broiler chickens(Ross 308)was randomly assigned to 6 treatments with 3 replications of 15 birds in each.Diets were comprised of the control(T1),the inclusion of T.vulgaris,G.glabra,their mixture(equal amount),Combo^(®)supplementation(T2,T3,T4 and T5,respectively)in diets based on corn-soybean meal diets and enzyme supplementation plus equal amount of tested medicinal plants(T6)based on barley-soybean meal diets.Medicinal plants and enzyme were included in diets at level 0.5%and 0.2%of diets,respectively.Results:The highest feed intake was obtained by T1 at 1-21 d of age(P<0.05).All diets caused significant increases in weight gain and significant decreases in feed conversion ratio compared to control at this age(P<0.05).Significant reductions were acquired in feed intake by T3 and T6 at 22-42 d of age(P<0.05).All diets significantly decreased total number of aerobic bacteria,coliforms,Gram-negative bacteria and increased lactic acid bacteria compared to control(P<0.05).Conclusions:The results showed that basal diet has vital character to effectiveness of medicinal plants in broiler diets.Beneficial effects on intestinal microflora were brought by use of T.vulgaris L.and G.glabra in corn-based diets or in barley-based diets together with enzyme.Thus,this capability can support growth performance of broiler chickens at lower age.展开更多
文摘Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).The United States Preventive Services Task Force(USPSTF) October 2015 draft recommendation for CRC screening included mt-s DNA as an "alternative" screening test that "may be useful in select clinical circumstances",despite its very high sensitivity for early stage CRC.The evidence supporting mt-s DNA for routine screening use is robust.The clinical efficacy of mt-s DNA as measured by sensitivity,specificity,life-years gained(LYG),and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document,especially those requiring annual testing adherence.In a population with primarily irregular screening participation,tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual adherence.This paper reviews the evidence supporting mt-s DNA for routine screening and demonstrates,using USPSTF's modeling data,that mt-s DNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing,high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening.
文摘Electrical conductivity(EC)is considered as the most important indicator for assessment of groundwater quality.Determination of suitable interpolation method for derivation of groundwater quality variables map such as EC is dependent on region conditions and existence of enough data.For determining groundwater EC,341 groundwater samples were randomly collected from the central regions of Guilan province,paddy soils,in northern Iran.Interpolation methods including inverse distance weighting(IDW),global polynomial interpolation(GPI),local polynomial interpolation(LPI),radial basis function(RBF),ordinary kriging(OK)and empirical Bayesian Kriging(EBK)were used to generate spatial distribution of groundwater EC.The results indicate that EBK is a superior method with the least RMSE,MAE and the highest R 2.The generated maps can be used to identify the regions in the studied area where groundwater could be allowed to be extracted and utilized by farmers to reduce adverse effect of the scarcity of surface water.
文摘Ancestors of human species have been living on the planet earth for about six million years while the modern form of humans only evolved about 200,000 years ago. Civilization is only about 6000 years old, and industrialization started in the 1800s. World population interconnectedness is enhanced with love and mercy but disrupted with dishonest, lies and wars. Human species has been feeding on animal fat as the finest and prime source of energy for all human history. In 1953 Ancel Keys and collaborates illusionized human kind that their historical source of energy is toxic. Massive health, behavioral as well as economic consequences followed. Human hearts known historically to be the seat of spirit, soul and emotions is proven by our group to orchestrate with global energetic fields. Global consciousness as represented by the planetary electromagnetic fields is in critical need to be feed with awakening merciful information. Documents refuting Ancek Keys dogma and reverting humanity to the truth in their energy source is presented in this review. The harmony we expect is not only physiological but will affect our global planetary environment for the wellbeing of human species in earth.
文摘2016 is the International Year of Global Understanding(IYGU).The IYGU declared by the three leading global sciences organizations of the natural,social,and human sciences recognizes that global social,cultural and climate changes require a global level of understanding.In this paper the basic IYGU guidelines are discussed,as well as the goals and action areas of this ambitious initiative.
基金Supported by Beijing Youth Talent Plan(No.YETP0787)Youth Teacher Fund of Beijing University of Chinese Medicine
文摘Objective： To develop a health-evaluating scale from a Chinese medicine（CM） perspective and reflecting CM conception of health. Methods： The Traditional Chinese Medicine Health Self-Evaluation Scale（TCM-50） was developed by verification of dimensions, formation of item pool, verification of scoring methodology, and pilot test of scale and item analysis. Results： TCM-50 composed of 50 items that could be classified into 4 dimensions including physiology and health, psychology and health, nature and health, and society and health. An examination of reliability and validity of TCM-50 yielded Cronbach＇s α coefficient of 0.927, and half coefficient of r was 0.876. The intraclass correlation coefficient of total score was 0.912. After using SF-36 questionnaire to evaluate the criterion validity, the Pearson r of the score of the two scales from the same participant was 0.740. Conclusions： TCM-50 has good reliability and validity, and can yield similar levels of efficacy as SF-36 in terms of evaluating people＇s overall health level. As a scale based on CM theory, TCM-50 is suitable for self-measuring the general health of Chinese patients.
基金Supported by Agricultural Research Center of Qom Fund,2013,Iran(Grant No:01-2-13-93018).
文摘Objective:To test the effect of supplementation of Thymus vulgaris L.(T.vulgaris)or Glycyrrhizaglabra(G.glabra)in corn-soybean meal diets as well as the inclusion of an exogenous enzyme i.e.Combo^(®)in barley-soybean meal diets together with mentioned medicinal plants in broiler diets.Methods:A total of 270 unsexed 1-day-old broiler chickens(Ross 308)was randomly assigned to 6 treatments with 3 replications of 15 birds in each.Diets were comprised of the control(T1),the inclusion of T.vulgaris,G.glabra,their mixture(equal amount),Combo^(®)supplementation(T2,T3,T4 and T5,respectively)in diets based on corn-soybean meal diets and enzyme supplementation plus equal amount of tested medicinal plants(T6)based on barley-soybean meal diets.Medicinal plants and enzyme were included in diets at level 0.5%and 0.2%of diets,respectively.Results:The highest feed intake was obtained by T1 at 1-21 d of age(P<0.05).All diets caused significant increases in weight gain and significant decreases in feed conversion ratio compared to control at this age(P<0.05).Significant reductions were acquired in feed intake by T3 and T6 at 22-42 d of age(P<0.05).All diets significantly decreased total number of aerobic bacteria,coliforms,Gram-negative bacteria and increased lactic acid bacteria compared to control(P<0.05).Conclusions:The results showed that basal diet has vital character to effectiveness of medicinal plants in broiler diets.Beneficial effects on intestinal microflora were brought by use of T.vulgaris L.and G.glabra in corn-based diets or in barley-based diets together with enzyme.Thus,this capability can support growth performance of broiler chickens at lower age.
