This paper analyzes the short-term and long-term effects that the global economic crisis and the investment priorities of the Chinese Government＇s stimulus package had on Chinese migrant flows between 2008 and 2014. ...This paper analyzes the short-term and long-term effects that the global economic crisis and the investment priorities of the Chinese Government＇s stimulus package had on Chinese migrant flows between 2008 and 2014. Combining micro-level household survey data and macro-level statistics, the authors have found that in the short run, the regional and sectoral impact of the crisis, combined with the government＇s investment priorities, caused a reorientation of migration routes from the export-oriented coastal provinces towards the central and western regions, from inter-provincial migration towards intra-provincial migration, and from manufacturing industry towards the construction sector. However, in the longer run, the decreasing attractiveness of the eastern region and the increasing attractiveness of the western region proved to be transitory, although the pre-crisis relative advantage of the eastern region was not fuUy restored. What proved to be persistent were the attractiveness of the central region and the intra-provincial migration in all three regions, and, in particular, the steady growth of migrants in the construction sector.展开更多
A new generation of novel,effective targeted drugs and cellular therapies include monoclonal antibodies directed at the cell surface,such as the anti-CD-19 tafasitamab which,combined with lenalidomide,is the first the...A new generation of novel,effective targeted drugs and cellular therapies include monoclonal antibodies directed at the cell surface,such as the anti-CD-19 tafasitamab which,combined with lenalidomide,is the first therapy approved by the Food and Drug Administration for second-line treatment of diffuse large B-cell lymphoma.Other agents interfere with pro-survival intracellular signaling pathways including drugs that inhibit Bruton tyrosine kinase,phosphatidylinositol-3 kinase(PI3-kinase),and bcl-2.An increasing number of therapies impact the microenvironment,notably checkpoint inhibitors and bispecific antibodies.Chimeric antigen receptor-T cell therapy has improved the outcome of patients with a variety of histologies of lymphoma.Whereas in the past,such therapies would be used inrelapsed and refractory settings,they are now being evaluated as initial treatment in selected patients.With an improved ability to individualize treatment approaches,chemo-free will be a reality for lymphoma patients.展开更多
文摘This paper analyzes the short-term and long-term effects that the global economic crisis and the investment priorities of the Chinese Government＇s stimulus package had on Chinese migrant flows between 2008 and 2014. Combining micro-level household survey data and macro-level statistics, the authors have found that in the short run, the regional and sectoral impact of the crisis, combined with the government＇s investment priorities, caused a reorientation of migration routes from the export-oriented coastal provinces towards the central and western regions, from inter-provincial migration towards intra-provincial migration, and from manufacturing industry towards the construction sector. However, in the longer run, the decreasing attractiveness of the eastern region and the increasing attractiveness of the western region proved to be transitory, although the pre-crisis relative advantage of the eastern region was not fuUy restored. What proved to be persistent were the attractiveness of the central region and the intra-provincial migration in all three regions, and, in particular, the steady growth of migrants in the construction sector.
文摘A new generation of novel,effective targeted drugs and cellular therapies include monoclonal antibodies directed at the cell surface,such as the anti-CD-19 tafasitamab which,combined with lenalidomide,is the first therapy approved by the Food and Drug Administration for second-line treatment of diffuse large B-cell lymphoma.Other agents interfere with pro-survival intracellular signaling pathways including drugs that inhibit Bruton tyrosine kinase,phosphatidylinositol-3 kinase(PI3-kinase),and bcl-2.An increasing number of therapies impact the microenvironment,notably checkpoint inhibitors and bispecific antibodies.Chimeric antigen receptor-T cell therapy has improved the outcome of patients with a variety of histologies of lymphoma.Whereas in the past,such therapies would be used inrelapsed and refractory settings,they are now being evaluated as initial treatment in selected patients.With an improved ability to individualize treatment approaches,chemo-free will be a reality for lymphoma patients.
