Host-yeast interactions are fundamental drivers of human microbiome dynamics,spanning a spectrum from mutualistic symbiosis to opportunistic pathogenesis with profound implications for systemic health.This review syst...Host-yeast interactions are fundamental drivers of human microbiome dynamics,spanning a spectrum from mutualistic symbiosis to opportunistic pathogenesis with profound implications for systemic health.This review systematically elucidates the complex molecular mechanisms governing these relationships,with a specific focus on metabolic interdependence and immunomodulation.We analyze how yeast-derived metabolites,particularly short-chain fatty acids(SCFAs),modulate host glucose and lipid homeostasis via signaling pathways such as GPR41/43 and GLP-1 secretion.Furthermore,the review explores the pathophysiological role of fungal dysbiosis in chronic conditions,including obesity,diabetes,and inflammatory bowel disease(IBD),highlighting how a breakdown in host-yeast homeostasis triggers pro-inflammatory cascades.Beyond the fungal-host axis,we introduce the concept of the"mycobiome-virome-bacterial axis,"discussing how commensal yeasts synergize with beneficial bacteria like Bifidobacterium and influence viral infectivity through Interferon-mediated innate immune priming.We critically evaluate how cutting-edge technologies-including transgenic mouse models(specifically Dectin-1^(-/-)and CARD9^(-/-),metabolomics,and single-cell sequencing-have revolutionized our mechanistic understanding of these multi-kingdom dynamics.By integrating current findings,we identify critical knowledge gaps and propose high-resolution research frameworks,such as humanized organ-on-a-chip systems,to simulate intricate host-microbe interactions under physiological flow conditions.This comprehensive synthesis provides a strategic foundation for developing targeted,next-generation microbiome-based interventions to restore host-yeast balance and enhance overall human health.展开更多
This report summarizes the nursing and infection management process for a patient who developed severe late-onset sinusoidal obstruction syndrome while in a state of deep immunosuppression after allogeneic hematopoiet...This report summarizes the nursing and infection management process for a patient who developed severe late-onset sinusoidal obstruction syndrome while in a state of deep immunosuppression after allogeneic hematopoietic stem cell transplantation.Key nursing measures included:strict adherence to infection control protocols in the laminar airflow ward during potent immunosuppressive therapy;rigorous aseptic techniques for invasive procedures such as abdominal paracentesis and drainage to prevent catheter-related infections;and enhanced monitoring and differentiation of symptoms like fever and diarrhea to guard against opportunistic infections.Symptom management for sinusoidal obstruction syndrome,nutritional support,and psychological care were implemented concurrently.Through these comprehensive nursing interventions,the patient recovered without developing any severe infections while immunocompromised.This case offers valuable insights into infection prevention and comprehensive care for similar high-risk patients.展开更多
基金funded by 2023 Chongqing medical scientific research project(Joint project of Chongqing Health Commission and Science and Technology Bureaugrant no.2023GGXM006)+12 种基金oint project of Chongqing Health Commission and Science and Technology Bureau(Joint Key Laboratory Open Project)(No.2026KFXM051)Natural Science Foundation of Chongqing(No.CSTB2025NSCO-GPX1116)2026 Chongqing Municipal Health Commission Traditional Chinese Medicine Research Project(No.2026WSJK158),Technological Innovation Project of Shapingba District,Chongqing(No.2025016)2024 Scientific research project of Chongqing Medical and Pharmaceutical College(No.ygzrc2024101)Chongqing Municipal Education Commission Youth Project(No.KJQN202402821No.KJQN202502819)2024 Chongqing Medical and Pharmaceutical College Innovation Research Group Project(No.ygz2024401)Science and Health Joint Medical Research Project of Shapingba District,Chongqing(No.2024SQKWLHMS051)2025 Scientific research project of Chongqing Medical and Pharmaceutical College(No.YGZZK2025116)2025 Technological Innovation Project of Shapingba District,Chongqing(No.2025031)Chongqing Municipal Education Commission Youth Project(No.KJQN202402821No.KJQN202302811)Joint project of Chongqing Health Commission and Science and Technology Bureau(No.2024MSXM115)respectively.
文摘Host-yeast interactions are fundamental drivers of human microbiome dynamics,spanning a spectrum from mutualistic symbiosis to opportunistic pathogenesis with profound implications for systemic health.This review systematically elucidates the complex molecular mechanisms governing these relationships,with a specific focus on metabolic interdependence and immunomodulation.We analyze how yeast-derived metabolites,particularly short-chain fatty acids(SCFAs),modulate host glucose and lipid homeostasis via signaling pathways such as GPR41/43 and GLP-1 secretion.Furthermore,the review explores the pathophysiological role of fungal dysbiosis in chronic conditions,including obesity,diabetes,and inflammatory bowel disease(IBD),highlighting how a breakdown in host-yeast homeostasis triggers pro-inflammatory cascades.Beyond the fungal-host axis,we introduce the concept of the"mycobiome-virome-bacterial axis,"discussing how commensal yeasts synergize with beneficial bacteria like Bifidobacterium and influence viral infectivity through Interferon-mediated innate immune priming.We critically evaluate how cutting-edge technologies-including transgenic mouse models(specifically Dectin-1^(-/-)and CARD9^(-/-),metabolomics,and single-cell sequencing-have revolutionized our mechanistic understanding of these multi-kingdom dynamics.By integrating current findings,we identify critical knowledge gaps and propose high-resolution research frameworks,such as humanized organ-on-a-chip systems,to simulate intricate host-microbe interactions under physiological flow conditions.This comprehensive synthesis provides a strategic foundation for developing targeted,next-generation microbiome-based interventions to restore host-yeast balance and enhance overall human health.
基金funded by Chongqing medical scientific research project(Joint project of Chongqing Health Commission and Science and Technology Bureau)(No.2023GGXM006)2025 Natural Science Foundation of Chongqing(No.CSTB2025NSCO-GPX1116)+3 种基金2024 Scientific research project of Chongqing Medical and Pharmaceutical College(No.ygzrc2024101)Chongqing Education Commission Natural Science Foundation(No.KJQN202402821 and No.KJQN202502819)2024 Chongqing Medical and Pharmaceutical College Innovation Research Group Project(No.ygz2024401)Chongqing Science and Health Joint Medical Research Project(No.2024SQKWLHMS051)
文摘This report summarizes the nursing and infection management process for a patient who developed severe late-onset sinusoidal obstruction syndrome while in a state of deep immunosuppression after allogeneic hematopoietic stem cell transplantation.Key nursing measures included:strict adherence to infection control protocols in the laminar airflow ward during potent immunosuppressive therapy;rigorous aseptic techniques for invasive procedures such as abdominal paracentesis and drainage to prevent catheter-related infections;and enhanced monitoring and differentiation of symptoms like fever and diarrhea to guard against opportunistic infections.Symptom management for sinusoidal obstruction syndrome,nutritional support,and psychological care were implemented concurrently.Through these comprehensive nursing interventions,the patient recovered without developing any severe infections while immunocompromised.This case offers valuable insights into infection prevention and comprehensive care for similar high-risk patients.
