Background Fast-growing broilers are poorly adapted to heat.Adjusting feed composition may mitigate heat stress(HS)effects in temperate climates,while maintaining performance and health during cooler days.Methods One ...Background Fast-growing broilers are poorly adapted to heat.Adjusting feed composition may mitigate heat stress(HS)effects in temperate climates,while maintaining performance and health during cooler days.Methods One thousand nine hundred and twenty Ross 308 male broilers were housed in 64 pens in 4 climate-controlled rooms,2 under cyclical HS(d 28–43;32±2℃;60%–70%RH;09:30–15:30)and 2 under thermoneutral(TN)conditions.In the finisher phase,broilers were allocated to 4 dietary treatments,analyzed values are given except for metabolizable energy(ME):low crude protein(CP)and control fat(LowCP-ConF;17.0%CP,5.9%crude fat(CF),2,925 kcal/kg ME),low CP and high fat(LowCP-HighF;17.2%CP,7.9%CF,3,019 kcal/kg ME),control CP and high fat(ConCP-HighF;18.1%CP,8.0%CF,2,992 kcal/kg ME)and a basal control(ConCP-ConF;18.7%CP,6.3%CF,2,913 kcal/kg ME).LowCP diets contained control levels of digestible amino acids.Results During the finisher phase,compared to control CP levels,LowCP increased average daily feed intake(ADFI)(+2.15%;P=0.020)and affected average daily gain(ADG)and feed conversion ratio(FCR)negatively under TN(-3.77%and+6.49%;P=0.003 and P<0.001,respectively),but not during HS.Compared to control CF,HighF decreased ADFI during TN and HS(-3.16%and-3.17%;P<0.001 and P=0.022)and reduced ADG in TN groups(-3.17%;P=0.010),but not during HS.Mortality was higher in broilers receiving HighF during HS(P=0.040).Slaughter weights were unaffected.LowCP decreased plasma uric acid and lactate dehydrogenase levels during TN,but increased plasma glucose during HS.LowCP increased breast meat redness(a*)during TN and HS(P<0.05).HighF decreased fat(-1.68%;P=0.017),but increased protein levels(+1.53%;P<0.001)in breast meat of HS-broilers.Conclusion LowCP and HighF impaired performance under TN but not under HS.HighF increased mortality under HS,yet improved breast meat composition.These findings highlight the challenge of designing an optimal diet for both conditions and underscore the need to better understand amino acid needs and energy-to-protein ratios during HS.展开更多
Objectives This study aimed to analyse the benefits of a gamified clinical supervision strategy during hospital-based training,particularly regarding the development of critical and reflective thinking among undergrad...Objectives This study aimed to analyse the benefits of a gamified clinical supervision strategy during hospital-based training,particularly regarding the development of critical and reflective thinking among undergraduate nursing students.Methods From April to July 2023,second-year nursing students who undertaking a nine-week clinical placement in a cardiology ward in northern Portugal were selected.Following a two-week diagnostic phase,students participated in a six-week gamified supervision programme comprising weekly 60-min sessions:infection-control decision-making;technical-procedural reasoning;guided emotional and ethical reflection;and clinical reasoning quiz on cardiology topics.Students completed weekly Structured Reflection Guide entries;supervisors recorded structured field notes after each session;and,after the intervention,students answered a post-intervention questionnaire and participated in focus groups.Qualitative data(reflections,field notes,open-ended questionnaire items,and focus-group transcripts)were analyzed using Bardin’s content analysis;quantitative questionnaire items were summarized descriptively.Results All seven students completed the six gamified sessions and submitted weekly reflection entries.Five students(71.4%)completed the questionnaire.Across data sources,students reported that gamified activities supported knowledge consolidation,teamwork,and clinical reasoning.Questionnaire data showed that all respondents(n=5,100%)strongly agreed that gamification enhanced their learning and should be maintained in clinical training.Reflections and focus groups revealed recurring themes related to emotional expression,sense of belonging,and difficulties using structured reflection tools,particularly in terms of comprehension and timing.Conclusion The gamified supervision strategy integrated into clinical training provided structured opportunities for practical engagement,collaborative work,and guided reflection.These findings suggest that gamification may support the development of reflective and critical-thinking processes in authentic clinical environments.展开更多
Background: We monitored changes in salivary creatine pre-and post-high-intensity exercise in young adults while also investigating the potential correlation between salivary and serum creatine levels.Method: Saliva a...Background: We monitored changes in salivary creatine pre-and post-high-intensity exercise in young adults while also investigating the potential correlation between salivary and serum creatine levels.Method: Saliva and serum samples were collected before and immediately after an incremental running-toexhaustion treadmill test in fifteen young adults(mean age [23.9 ± 2.9] years, eight females), with samples analyzed for guanidinoacetic acid, creatine, and creatinine using a liquid chromatography–tandem mass spectrometry method.Results: Following exercise, there was a substantial elevation in salivary creatine levels from(17.5 ± 14.2)μmol·L^(-1) to(43.6 ± 30.4) μmol·L^(-1)(p < 0.001), coupled with a significant increase in salivary creatinine from(11.3 ± 5.8) μmol·L^(-1) to(17.0 ± 9.3) μmol·L^(-1)(p = 0.04). In contrast, serum creatine levels were unaffected by exercise(p = 0.80), while creatinine levels exhibited a strong tendency to decrease post-exercise(from [81.8 ±17.5] μmol·L^(-1) to [73.1 ± 11.6] μmol·L^(-1);p = 0.06). A comparison of the slopes of the two regression lines(saliva vs. serum) revealed significant differences for both creatine(p = 0.01) and creatinine(p = 0.03).Conclusions: The above findings suggest a potential difference in the dynamics of creatine metabolites in these two bodily fluids, both pre and post-exercise.展开更多
Artificial intelligence(AI)is increasingly recognized as a transformative force in the field of solid organ transplantation.From enhancing donor-recipient matching to predicting clinical risks and tailoring immunosupp...Artificial intelligence(AI)is increasingly recognized as a transformative force in the field of solid organ transplantation.From enhancing donor-recipient matching to predicting clinical risks and tailoring immunosuppressive therapy,AI has the potential to improve both operational efficiency and patient outcomes.Despite these advancements,the perspectives of transplant professionals-those at the forefront of critical decision-making-remain insufficiently explored.To address this gap,this study utilizes a multi-round electronic Delphi approach to gather and analyses insights from global experts involved in organ transplantation.Participants are invited to complete structured surveys capturing demographic data,professional roles,institutional practices,and prior exposure to AI technologies.The survey also explores perceptions of AI’s potential benefits.Quantitative responses are analyzed using descriptive statistics,while open-ended qualitative responses undergo thematic analysis.Preliminary findings indicate a generally positive outlook on AI’s role in enhancing transplantation processes,particularly in areas such as donor matching and post-operative care.These mixed views reflect both optimism and caution among professionals tasked with integrating new technologies into high-stakes clinical workflows.By capturing a wide range of expert opinions,the findings will inform future policy development,regulatory considerations,and institutional readiness frameworks for the integration of AI into organ transplantation.展开更多
Sand encroachment into urban areas represents a high risk factor for transportation infrastructural and urban development in the United Arab Emirates. The UAE is located in one of the world’s largest arid regions wit...Sand encroachment into urban areas represents a high risk factor for transportation infrastructural and urban development in the United Arab Emirates. The UAE is located in one of the world’s largest arid regions with a strong prevalence of sand movement and encroachment into urban areas, particularly in the last few years. The objective of this research is to develop a land surface process platform that models sand movements and further generates an encroachment risk index map of potential encroachment risk areas season-wise in the UAE. To achieve this objective, this research used elevation and land cover maps generated from Lands at 8 Operational Land Imager (OLI) data which represent the topography of the study area coupled with meteorological information on wind speed, temperature and precipitation. Furthermore, the study considered the vegetation cover as a major contribution factor to reduce sand encroachment. Using developed sand movement model for this research, sand encroachment risk maps were generated to help urban planners in cities making informed decisions of future urban protection structures and transportation networks that mitigate the effects of sand dunes encroachments in the UAE. A major finding of this research results conclude that during the summer season encroachment risk reaches 30% higher compared to the winter season due to the extremely high temperature which leads to reduced vegetation in the country. Urban planning decision maker may consider the finding of this research for future infrastructural adjustments.展开更多
Large volumes of water are generated in gas- and oil-production. This includes the water that is present originally in the reservoirs, but also water that is injected into the wells. While currently much of the produc...Large volumes of water are generated in gas- and oil-production. This includes the water that is present originally in the reservoirs, but also water that is injected into the wells. While currently much of the produced water is either reinjected or disposed of after treatment, treated produced water is increasingly seen as an interesting resource, especially in water-scarce regions. This review looks at different PW treatment methods available, with an emphasis on the management of PW in oil- and gas production on the Arabian Peninsula.展开更多
In order to find out whether any toothpastes commercially available in the United Arab Emirates (UAE) carry microplastic content in form of plastic microbeads, the filterable solid contents of 31 toothpastes from UAE ...In order to find out whether any toothpastes commercially available in the United Arab Emirates (UAE) carry microplastic content in form of plastic microbeads, the filterable solid contents of 31 toothpastes from UAE markets and 2 toothpastes imported from Syria were analyzed. FT-IR studies of the solids revealed that the major solid components were hydrated silica and calcium carbonate, where the individual toothpaste product exhibited either one or the other as the dominant constituent. Titrimetric analysis of the alkalinity of the ash of the toothpastes was carried out. The solids, ashed at 600°C were subjected to FT-IR and EDS (energy dispersive X-ray spectroscopic) analysis. The ash of some of the products was shown to have TiO<sub>2</sub> and Ca<sub>3</sub> (PO<sub>4</sub>)<sub>2</sub> as minor components. Mostly organic dyes were used as colorants;however, iron oxide (Fe<sub>2</sub>O<sub>3</sub>) was also found. Importantly, none of the toothpastes carried any solid microplastic particles. Only 3 toothpastes carried microbeads at all, which were made of either silica or microcrystalline cellulose. This finding indicates that toothpastes, at least in the UAE, are no longer a significant source of microplastic in the environment. The results were compared to a toothpaste bought through the internet with a formulation from 2014, which exhibited polythene microplastic at 1.31 ± 0.39 w% of the filterable solid content.展开更多
Objectives The aim of this study was to analyze the psychometric properties(reliability and validity)of the Social Isolation Scale(SIS)in a sample of Portuguese community-dwelling older adults.Methods A transversal de...Objectives The aim of this study was to analyze the psychometric properties(reliability and validity)of the Social Isolation Scale(SIS)in a sample of Portuguese community-dwelling older adults.Methods A transversal descriptive study was carried out with a convenience sample of 250 community-dwelling older adults(≥65 years).The survey comprised a sociodemographic questionnaire,SIS,Geriatric Depression Scale-4(GDS-4),6-item Lubben Social Network Scale(LSNS-6),a loneliness self-assessment question,and Satisfaction with Life Scale(SWLS).Construct validity(confirmatory factor analysis)and convergent validity were analyzed,and ISI internal reliability(composite reliability),external reliability(test-retest,intraclass correlation coefficient)and inter-rater reliability(Cohen’s kappa coefficient)were evaluated.Results Confirmatory factor analysis showed a two-factor model with an excellent index of fit.The SIS showed significant correlations with LSNS-6(rs=0.47),SWLS(rs=0.26),the loneliness self-assessment question(rs=0.35),and GDS-4(rs=−0.16).SIS composite reliability was good(0.708).The inter-class correlation coefficient varied from 0.84 to 0.98.The Cohen’s kappa coefficient ranged from 0.936 to 1.Conclusions SIS has been shown to be a valid and reliable instrument for assessing social isolation among Portuguese community-dwelling older adults.Healthcare professionals,particularly nurses working in community settings,can use SIS to assess social isolation in older adults to design,implement,and evaluate interventions.展开更多
Calcite and quartz veins in the gabbroic and dunite rocks of the Semial ophiolite (UAE) were selected for fluid inclusion analysis. The inclusions contain both aqueous low-salinity and hydrocarbon-dominated fluids. Mi...Calcite and quartz veins in the gabbroic and dunite rocks of the Semial ophiolite (UAE) were selected for fluid inclusion analysis. The inclusions contain both aqueous low-salinity and hydrocarbon-dominated fluids. Mi-crothermometry data indicate that the aqueous fluids contain 0.22 to 1.45 equivalent wt% NaCl and occasionally contain traces of hydrocarbons. Homogenization to liquid occurred between 91 and 152℃. Modeling based on these fluid inclusion observations indicates that the trapping conditions of the studied rocks were subjected to temperatures of 162 and 172℃, occasional pressures of 610-710 Pa and the sequence percolation of aqueous and hydrocarbon fluids.展开更多
Microplastic content was analyzed in road dust, soils alongside roads and stormwater run-offs in Al Ain City, Abu Dhabi. Apart from tire wear material, fibers and degradation products of meso- and macroplastics such a...Microplastic content was analyzed in road dust, soils alongside roads and stormwater run-offs in Al Ain City, Abu Dhabi. Apart from tire wear material, fibers and degradation products of meso- and macroplastics such as plastic bags and plastic bottle tops were found to be the most dominant plastic microparticles. Speed bumps and artificial turf/lawns were also evaluated as potential sources of microplastics on and alongside roads. It was found that in arid regions Aeolian transport of microplastics may be more important than transport by water.展开更多
The objective of the study was to identify the failure factors of community interventions in terms of HIV activities in the province of Haut-Katanga during the year 2016. Materials and Methods: The study was phenomeno...The objective of the study was to identify the failure factors of community interventions in terms of HIV activities in the province of Haut-Katanga during the year 2016. Materials and Methods: The study was phenomenological of the factors, carried out in Haut Katanga. All health facilities (FOSAs) having integrated the prevention of transmission of HIV infection from mother to child (PMTCT) were included in the study. The collection was carried out through individual semi-structured interviews with PMTCT focal points, mentor mothers and people living with HIV (PLWHA) cared for in some of these health facilities (FOSAs). The number of participants was determined by the saturation of responses. Nvivo v.11 software was used for the analyses. The data of each woman was handled confidentially. The authorization of the ethics committee of the University of Kinshasa ESP/CE091/2015, the free and written consent, was obtained before collecting the information. Results: It was observed the socio-cultural factors of success and failure of the interventions: the social fear generated by contradictory messages in the sensitization of the community;the lack of an obvious strategy for the involvement of the partner;the weak coordination of community care activities between the central office of the health zone;the FOSA and the community worker: low interest in community care evidenced by weak accountability of FOSAs, community and program providers in this regard;that relates to community activities;coordination of care between care units;overload of the staff in charge of activities within the health structure and their low motivation;the low communication time devoted to people living with HIV in the FOSAs. Conclusion: The study shows that interventions that can improve the quality and outcomes of prevention of mother-to-child transmission of HIV (PMTCT) services can be directly linked to the program itself, as well as come from another or the community, which generally remains the weak link in which efforts are even less noticeable, at least as far as PMTCT is concerned. Integrating care data for the mother-child couple improve the continuum of services between the different care units as well as the quality of data management.展开更多
Microplastics (MPs) have been an emerging concern due to their harmful effects on the ecosystem and are ubiquitous in various habitats, from marine to terrestrial environments. However, studies on the presence of MPs ...Microplastics (MPs) have been an emerging concern due to their harmful effects on the ecosystem and are ubiquitous in various habitats, from marine to terrestrial environments. However, studies on the presence of MPs in recreational areas are limited. One of the previous works has reported that urban recreational parks are considered “sinks” for plastic debris, including MPs. In this study, low-density MPs (LD-MPs) in soil samples collected from recreational parks of Al Ain, United Arab Emirates (UAE) were isolated by density flotation method. Results showed that these parks have varying levels of LD-MPs caused by various anthropogenic activities, such as sludge use and application of reclaimed water from wastewater treatment facilities in those areas. These plastic particles were isolated in 87% of the soil samples, with an average concentration of 1550 ± 340 MPs/kg. Predominantly, these comprised large LD-MPs (300 - 5000 μm), with red and blue being the most common colors. Fourier transform infrared (FTIR) spectroscopy identified possible synthetic polymers, including polyethylene and polypropylene. Additionally, a negative correlation was observed between LD-MP concentration and soil pH and moisture content, indicating potential adverse effects on soil health. These findings highlight the need for monitoring and managing microplastic pollution in urban recreational areas to mitigate its ecological impacts.展开更多
This study describes the bio-ecology of local Anopheles vectors, their abundance, type and vectoral competence in three communities around Kumasi Metropolis. The study sites were selected based on bio-ecologic zones ...This study describes the bio-ecology of local Anopheles vectors, their abundance, type and vectoral competence in three communities around Kumasi Metropolis. The study sites were selected based on bio-ecologic zones （urban, peri-urban and rural） which influence habitat and behavior. Pyrethrum spray catch was used in the collection of indoor resting mosquitoes from bedrooms of study communities （June-August 2008）. The identification of mosquitoes was based on morphological keys earlier described. The blood meal taken and the stage of digestion and egg development were also observed. A total of 293 mosquitoes were collected and 50.5% were A. gambiae s.I. Of the three bio-ecologic zones： urban, 53.4% were A. gambiae s.l, 27.2% Culex and 19.4% Mansonia; peri-urban, 58% A. gambiae s. 1 and 42% Culex pipien s. 1 and rural, 40.2% A. gambiae s. 1, and 58.8% Culex sp respectively. About 96.6% of all mosquitoes collected had taken blood meals, with 50% of these being Anopheles gambiae s.I. Our findings indicate that urban rather exhibits rural characteristics and can best be described as ＂urban poor＂. However, more data need to be collected to ascertain this. The anopheline mosquitoes in the study communities are highly endophillic and anthropophagic and thus have high vectoral competence. The authors recommend frequent mosquito surveillance to avert malaria epidemic.展开更多
Globally, one of the most devastating diseases of sorghum is anthracnose incited by Colletotrichum sublineola. During the 2019 and 2020 growing seasons, 94 and 64 accessions from the Ethiopian sorghum germplasm collec...Globally, one of the most devastating diseases of sorghum is anthracnose incited by Colletotrichum sublineola. During the 2019 and 2020 growing seasons, 94 and 64 accessions from the Ethiopian sorghum germplasm collection maintained by the National Genetic Resources Program of the United States Department of Agriculture were evaluated for anthracnose resistance. Seeds were planted in 1.8 m rows with 0.9 m row spacing in a randomized complete block design. The accessions and checks were replicated three times and 30 days after planting, inoculated by placing C. sublineola-colonized grains in the plant whorls. A total of 30 accessions, including PI533918, PI533923, PI534131 and PI534151 were resistant to the disease in both years. These identified resistant sources can be used in breeding programs to develop anthracnose-resistant lines and hybrids.展开更多
Globally,there have been multiple public health emergencies in recent decades.High rates of morbidity,occasionally mortality,and economic instability are usually associated with pandemics.One of the epidemics that has...Globally,there have been multiple public health emergencies in recent decades.High rates of morbidity,occasionally mortality,and economic instability are usually associated with pandemics.One of the epidemics that has significantly increased morbidity and mortality worldwide is the human immunodeficiency virus(HIV)and acquired immune deficiency syndrome(AIDS)pandemic.HIV has a disproportionately negative impact on key populations.Strong leadership,effective communication,and sound science are necessary for public health emergency(PHE)responses to be successful.These three PHE response pllars are also essential for bridging the HIV response gap among key populations in the setting of restrictive laws.In this review,we explored the importance of these three pillars of successful PHEs responses,and how they are essential to closing the gap in the HIV response among key populations.Leaders must make decisions and instil a sense of authority in the populace during PHEs to foster trust and confidence.Leaders should base their choices on scientific evidence.Effective communication during PHEs should be proactive,polite,imaginative,innovative,and constructive.To address gaps in the HIV response among key populations,leaders must create a supportive environment for effective communication and scientific research,communication should be used to raise awareness of HIV and to dispel stigma and discrimination,while science should provide evidence of efficacy and effectiveness of interventions amongkey populations.展开更多
This study explores the mathematical practices embedded in the cultural traditions of the Tharu community, with a focus on their counting systems, measuring techniques, and modeling patterns. Through ethnographic obse...This study explores the mathematical practices embedded in the cultural traditions of the Tharu community, with a focus on their counting systems, measuring techniques, and modeling patterns. Through ethnographic observations and field interviews, the research reveals how the Tharu people employ a base-20 counting system influenced by the Nepali numbering system and use physical objects for arithmetic operations. Their traditional measuring techniques rely on body-referenced units such as the Haat (hand) and Anguli (finger) for length, along with culturally specific units like the Muthi and Lota for volume. Additionally, the study examines the geometric patterns found in Tharu crafts, highlighting the community’s application of symmetry and ratios. The findings illustrate the significance of these ethnomathematical practices in the daily life of the Tharu people, offering insight into how indigenous mathematical knowledge can enrich the broader understanding of mathematics education. This research contributes to the field of ethnomathematics by documenting and analyzing the ways in which cultural groups integrate mathematical concepts to solve practical problems and preserve their heritage.展开更多
Air quality was measured inside 628 United Arab Emirates (UAE) personal residences. Weekly average concentrations of carbon monoxide (CO), formaldehyde (HCHO), hydrogen sulfide (H2S), nitrogen dioxide (NO2), sulfur di...Air quality was measured inside 628 United Arab Emirates (UAE) personal residences. Weekly average concentrations of carbon monoxide (CO), formaldehyde (HCHO), hydrogen sulfide (H2S), nitrogen dioxide (NO2), sulfur dioxide (SO2), and three size fractions of particulate matter (PM2.5, PMc, and PM10) were determined in each home. In a subset of the homes, measurements of outdoor air quality, ultrafine PM concentrations, and elemental PM concentrations were also made. Questionnaires were administered to obtain information on housing demographics and lifestyle habits. Air measurements were performed using simple and cost effective passive samplers. The 90th percentiles of indoor CO, HCHO, H2S, NO2, and SO2 were 1.55 ppm, 0.05 ppm, 0.12 ppm, 0.01 ppm, and 0.05 ppm, respectively. Median indoor PM2.5, PMc, and PM10, concentrations were 5.73 μg/m3, 29.4 μg/m3, and 35.2 μg/m3, respectively. The median indoor concentration of ultrafine PM was 3.62 × 1010 particles/m3. Indoor/outdoor ratios for PM were 0.44, 0.41, and 0.38 for ultrafine PM, PM2.5, and PM10, respectively. These values fall within the range of other indoor air studies findings conducted in developing countries. Air conditioning, smoking, and attached kitchens were significantly correlated with indoor levels of carbon monoxide. In addition, indoor concentrations of PM2.5 and PM10 were significantly correlated with vehicles parked within five meters of the home, central air conditioning, and having attached kitchens. This is the first robust indoor air quality data set developed for the UAE. This study demonstrates that screening level tools are a good initial step for assessing air quality when logistical issues (distance, language, cultural, training) and intrusion into personal lives need to be minimized.展开更多
Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fi-brosis,which appears to be a leading cause of cardiovascular diseases.Cardiac fi-brosis is characterized by the accumulation of extra...Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fi-brosis,which appears to be a leading cause of cardiovascular diseases.Cardiac fi-brosis is characterized by the accumulation of extracellular matrix proteins,mainly collagen in the cardiac interstitium.Many experimental studies have demonstrated that fibrotic injury in the heart is reversible;therefore,it is vital to understand differ-ent molecular mechanisms that are involved in the initiation,progression,and resolu-tion of cardiac fibrosis to enable the development of antifibrotic agents.Of the many experimental models,one of the recent models that has gained renewed interest is isoproterenol(ISP)-induced cardiac fibrosis.ISP is a synthetic catecholamine,sympa-thomimetic,and nonselectiveβ-adrenergic receptor agonist.The overstimulated and sustained activation ofβ-adrenergic receptors has been reported to induce biochemi-cal and physiological alterations and ultimately result in cardiac remodeling.ISP has been used for decades to induce acute myocardial infarction.However,the use of low doses and chronic administration of ISP have been shown to induce cardiac fibrosis;this practice has increased in recent years.Intraperitoneal or subcutaneous ISP has been widely used in preclinical studies to induce cardiac remodeling manifested by fibrosis and hypertrophy.The induced oxidative stress with subsequent perturbations in cellular signaling cascades through triggering the release of free radicals is consid-ered the initiating mechanism of myocardial fibrosis.ISP is consistently used to induce fibrosis in laboratory animals and in cardiomyocytes isolated from animals.In recent years,numerous phytochemicals and synthetic molecules have been evaluated in ISP-induced cardiac fibrosis.The present review exclusively provides a comprehensive summary of the pathological biochemical,histological,and molecular mechanisms of ISP in inducing cardiac fibrosis and hypertrophy.It also summarizes the application of this experimental model in the therapeutic evaluation of natural as well as syn-thetic compounds to demonstrate their potential in mitigating myocardial fibrosis and hypertrophy.展开更多
Background:Diabetes mellitus(DM),a metabolic disorder that leads to chronic hyperglycemia,is one of the topmost global public health concerns according to the International Diabetes Federation.Adropin is a peptide hor...Background:Diabetes mellitus(DM),a metabolic disorder that leads to chronic hyperglycemia,is one of the topmost global public health concerns according to the International Diabetes Federation.Adropin is a peptide hormone that is primarily involved in energy homeostasis,but its involvement in other biological activities such as lowering hyperlipidemia,and diminishing insulin resistance has also been reported.In this study,we aimed to explore additional effects of adropin on oxidative stress,inflammation,and cell proliferation in an animal model of type 1 DM.Methods:To achieve our aim,normal and diabetic Wistar rats were treated with adropin(2.1μg/kg/day)for a period of 10 days.Pancreatic tissue samples were collected for histomorphological analysis and inflammation assay,while blood was collected for oxidative stress assay.Results:Our results showed that diabetes induction stimulated cell proliferation in both exocrine and endocrine pancreas,and adropin dramatically attenuated this effect in pancreatic exocrine tissue,but not in the islet of Langerhans.In addition,adropin significantly increased glutathione reductase expression in pancreatic tissue,and augmented serum total glutathione in the diabetic rats compared to diabetic untreated rats.Conclusion:Our study indicates the potential role of adropin in alleviating oxidative stress in DM.展开更多
基金funded by VLAIO(Flemish Innovation&Entrepreneurship),grant number HBC.2020.3165。
文摘Background Fast-growing broilers are poorly adapted to heat.Adjusting feed composition may mitigate heat stress(HS)effects in temperate climates,while maintaining performance and health during cooler days.Methods One thousand nine hundred and twenty Ross 308 male broilers were housed in 64 pens in 4 climate-controlled rooms,2 under cyclical HS(d 28–43;32±2℃;60%–70%RH;09:30–15:30)and 2 under thermoneutral(TN)conditions.In the finisher phase,broilers were allocated to 4 dietary treatments,analyzed values are given except for metabolizable energy(ME):low crude protein(CP)and control fat(LowCP-ConF;17.0%CP,5.9%crude fat(CF),2,925 kcal/kg ME),low CP and high fat(LowCP-HighF;17.2%CP,7.9%CF,3,019 kcal/kg ME),control CP and high fat(ConCP-HighF;18.1%CP,8.0%CF,2,992 kcal/kg ME)and a basal control(ConCP-ConF;18.7%CP,6.3%CF,2,913 kcal/kg ME).LowCP diets contained control levels of digestible amino acids.Results During the finisher phase,compared to control CP levels,LowCP increased average daily feed intake(ADFI)(+2.15%;P=0.020)and affected average daily gain(ADG)and feed conversion ratio(FCR)negatively under TN(-3.77%and+6.49%;P=0.003 and P<0.001,respectively),but not during HS.Compared to control CF,HighF decreased ADFI during TN and HS(-3.16%and-3.17%;P<0.001 and P=0.022)and reduced ADG in TN groups(-3.17%;P=0.010),but not during HS.Mortality was higher in broilers receiving HighF during HS(P=0.040).Slaughter weights were unaffected.LowCP decreased plasma uric acid and lactate dehydrogenase levels during TN,but increased plasma glucose during HS.LowCP increased breast meat redness(a*)during TN and HS(P<0.05).HighF decreased fat(-1.68%;P=0.017),but increased protein levels(+1.53%;P<0.001)in breast meat of HS-broilers.Conclusion LowCP and HighF impaired performance under TN but not under HS.HighF increased mortality under HS,yet improved breast meat composition.These findings highlight the challenge of designing an optimal diet for both conditions and underscore the need to better understand amino acid needs and energy-to-protein ratios during HS.
文摘Objectives This study aimed to analyse the benefits of a gamified clinical supervision strategy during hospital-based training,particularly regarding the development of critical and reflective thinking among undergraduate nursing students.Methods From April to July 2023,second-year nursing students who undertaking a nine-week clinical placement in a cardiology ward in northern Portugal were selected.Following a two-week diagnostic phase,students participated in a six-week gamified supervision programme comprising weekly 60-min sessions:infection-control decision-making;technical-procedural reasoning;guided emotional and ethical reflection;and clinical reasoning quiz on cardiology topics.Students completed weekly Structured Reflection Guide entries;supervisors recorded structured field notes after each session;and,after the intervention,students answered a post-intervention questionnaire and participated in focus groups.Qualitative data(reflections,field notes,open-ended questionnaire items,and focus-group transcripts)were analyzed using Bardin’s content analysis;quantitative questionnaire items were summarized descriptively.Results All seven students completed the six gamified sessions and submitted weekly reflection entries.Five students(71.4%)completed the questionnaire.Across data sources,students reported that gamified activities supported knowledge consolidation,teamwork,and clinical reasoning.Questionnaire data showed that all respondents(n=5,100%)strongly agreed that gamification enhanced their learning and should be maintained in clinical training.Reflections and focus groups revealed recurring themes related to emotional expression,sense of belonging,and difficulties using structured reflection tools,particularly in terms of comprehension and timing.Conclusion The gamified supervision strategy integrated into clinical training provided structured opportunities for practical engagement,collaborative work,and guided reflection.These findings suggest that gamification may support the development of reflective and critical-thinking processes in authentic clinical environments.
文摘Background: We monitored changes in salivary creatine pre-and post-high-intensity exercise in young adults while also investigating the potential correlation between salivary and serum creatine levels.Method: Saliva and serum samples were collected before and immediately after an incremental running-toexhaustion treadmill test in fifteen young adults(mean age [23.9 ± 2.9] years, eight females), with samples analyzed for guanidinoacetic acid, creatine, and creatinine using a liquid chromatography–tandem mass spectrometry method.Results: Following exercise, there was a substantial elevation in salivary creatine levels from(17.5 ± 14.2)μmol·L^(-1) to(43.6 ± 30.4) μmol·L^(-1)(p < 0.001), coupled with a significant increase in salivary creatinine from(11.3 ± 5.8) μmol·L^(-1) to(17.0 ± 9.3) μmol·L^(-1)(p = 0.04). In contrast, serum creatine levels were unaffected by exercise(p = 0.80), while creatinine levels exhibited a strong tendency to decrease post-exercise(from [81.8 ±17.5] μmol·L^(-1) to [73.1 ± 11.6] μmol·L^(-1);p = 0.06). A comparison of the slopes of the two regression lines(saliva vs. serum) revealed significant differences for both creatine(p = 0.01) and creatinine(p = 0.03).Conclusions: The above findings suggest a potential difference in the dynamics of creatine metabolites in these two bodily fluids, both pre and post-exercise.
文摘Artificial intelligence(AI)is increasingly recognized as a transformative force in the field of solid organ transplantation.From enhancing donor-recipient matching to predicting clinical risks and tailoring immunosuppressive therapy,AI has the potential to improve both operational efficiency and patient outcomes.Despite these advancements,the perspectives of transplant professionals-those at the forefront of critical decision-making-remain insufficiently explored.To address this gap,this study utilizes a multi-round electronic Delphi approach to gather and analyses insights from global experts involved in organ transplantation.Participants are invited to complete structured surveys capturing demographic data,professional roles,institutional practices,and prior exposure to AI technologies.The survey also explores perceptions of AI’s potential benefits.Quantitative responses are analyzed using descriptive statistics,while open-ended qualitative responses undergo thematic analysis.Preliminary findings indicate a generally positive outlook on AI’s role in enhancing transplantation processes,particularly in areas such as donor matching and post-operative care.These mixed views reflect both optimism and caution among professionals tasked with integrating new technologies into high-stakes clinical workflows.By capturing a wide range of expert opinions,the findings will inform future policy development,regulatory considerations,and institutional readiness frameworks for the integration of AI into organ transplantation.
文摘Sand encroachment into urban areas represents a high risk factor for transportation infrastructural and urban development in the United Arab Emirates. The UAE is located in one of the world’s largest arid regions with a strong prevalence of sand movement and encroachment into urban areas, particularly in the last few years. The objective of this research is to develop a land surface process platform that models sand movements and further generates an encroachment risk index map of potential encroachment risk areas season-wise in the UAE. To achieve this objective, this research used elevation and land cover maps generated from Lands at 8 Operational Land Imager (OLI) data which represent the topography of the study area coupled with meteorological information on wind speed, temperature and precipitation. Furthermore, the study considered the vegetation cover as a major contribution factor to reduce sand encroachment. Using developed sand movement model for this research, sand encroachment risk maps were generated to help urban planners in cities making informed decisions of future urban protection structures and transportation networks that mitigate the effects of sand dunes encroachments in the UAE. A major finding of this research results conclude that during the summer season encroachment risk reaches 30% higher compared to the winter season due to the extremely high temperature which leads to reduced vegetation in the country. Urban planning decision maker may consider the finding of this research for future infrastructural adjustments.
文摘Large volumes of water are generated in gas- and oil-production. This includes the water that is present originally in the reservoirs, but also water that is injected into the wells. While currently much of the produced water is either reinjected or disposed of after treatment, treated produced water is increasingly seen as an interesting resource, especially in water-scarce regions. This review looks at different PW treatment methods available, with an emphasis on the management of PW in oil- and gas production on the Arabian Peninsula.
文摘In order to find out whether any toothpastes commercially available in the United Arab Emirates (UAE) carry microplastic content in form of plastic microbeads, the filterable solid contents of 31 toothpastes from UAE markets and 2 toothpastes imported from Syria were analyzed. FT-IR studies of the solids revealed that the major solid components were hydrated silica and calcium carbonate, where the individual toothpaste product exhibited either one or the other as the dominant constituent. Titrimetric analysis of the alkalinity of the ash of the toothpastes was carried out. The solids, ashed at 600°C were subjected to FT-IR and EDS (energy dispersive X-ray spectroscopic) analysis. The ash of some of the products was shown to have TiO<sub>2</sub> and Ca<sub>3</sub> (PO<sub>4</sub>)<sub>2</sub> as minor components. Mostly organic dyes were used as colorants;however, iron oxide (Fe<sub>2</sub>O<sub>3</sub>) was also found. Importantly, none of the toothpastes carried any solid microplastic particles. Only 3 toothpastes carried microbeads at all, which were made of either silica or microcrystalline cellulose. This finding indicates that toothpastes, at least in the UAE, are no longer a significant source of microplastic in the environment. The results were compared to a toothpaste bought through the internet with a formulation from 2014, which exhibited polythene microplastic at 1.31 ± 0.39 w% of the filterable solid content.
基金supported by national funds through FCT-Fundaçao para a Ciencia e a Tecnologia,I.P.,within CINTESIS R&D Unit(UIDB/4255/2020 and UIDP/4255/2020)within the scope of the project RISE(LA/P/0053/2020).
文摘Objectives The aim of this study was to analyze the psychometric properties(reliability and validity)of the Social Isolation Scale(SIS)in a sample of Portuguese community-dwelling older adults.Methods A transversal descriptive study was carried out with a convenience sample of 250 community-dwelling older adults(≥65 years).The survey comprised a sociodemographic questionnaire,SIS,Geriatric Depression Scale-4(GDS-4),6-item Lubben Social Network Scale(LSNS-6),a loneliness self-assessment question,and Satisfaction with Life Scale(SWLS).Construct validity(confirmatory factor analysis)and convergent validity were analyzed,and ISI internal reliability(composite reliability),external reliability(test-retest,intraclass correlation coefficient)and inter-rater reliability(Cohen’s kappa coefficient)were evaluated.Results Confirmatory factor analysis showed a two-factor model with an excellent index of fit.The SIS showed significant correlations with LSNS-6(rs=0.47),SWLS(rs=0.26),the loneliness self-assessment question(rs=0.35),and GDS-4(rs=−0.16).SIS composite reliability was good(0.708).The inter-class correlation coefficient varied from 0.84 to 0.98.The Cohen’s kappa coefficient ranged from 0.936 to 1.Conclusions SIS has been shown to be a valid and reliable instrument for assessing social isolation among Portuguese community-dwelling older adults.Healthcare professionals,particularly nurses working in community settings,can use SIS to assess social isolation in older adults to design,implement,and evaluate interventions.
文摘Calcite and quartz veins in the gabbroic and dunite rocks of the Semial ophiolite (UAE) were selected for fluid inclusion analysis. The inclusions contain both aqueous low-salinity and hydrocarbon-dominated fluids. Mi-crothermometry data indicate that the aqueous fluids contain 0.22 to 1.45 equivalent wt% NaCl and occasionally contain traces of hydrocarbons. Homogenization to liquid occurred between 91 and 152℃. Modeling based on these fluid inclusion observations indicates that the trapping conditions of the studied rocks were subjected to temperatures of 162 and 172℃, occasional pressures of 610-710 Pa and the sequence percolation of aqueous and hydrocarbon fluids.
文摘Microplastic content was analyzed in road dust, soils alongside roads and stormwater run-offs in Al Ain City, Abu Dhabi. Apart from tire wear material, fibers and degradation products of meso- and macroplastics such as plastic bags and plastic bottle tops were found to be the most dominant plastic microparticles. Speed bumps and artificial turf/lawns were also evaluated as potential sources of microplastics on and alongside roads. It was found that in arid regions Aeolian transport of microplastics may be more important than transport by water.
文摘The objective of the study was to identify the failure factors of community interventions in terms of HIV activities in the province of Haut-Katanga during the year 2016. Materials and Methods: The study was phenomenological of the factors, carried out in Haut Katanga. All health facilities (FOSAs) having integrated the prevention of transmission of HIV infection from mother to child (PMTCT) were included in the study. The collection was carried out through individual semi-structured interviews with PMTCT focal points, mentor mothers and people living with HIV (PLWHA) cared for in some of these health facilities (FOSAs). The number of participants was determined by the saturation of responses. Nvivo v.11 software was used for the analyses. The data of each woman was handled confidentially. The authorization of the ethics committee of the University of Kinshasa ESP/CE091/2015, the free and written consent, was obtained before collecting the information. Results: It was observed the socio-cultural factors of success and failure of the interventions: the social fear generated by contradictory messages in the sensitization of the community;the lack of an obvious strategy for the involvement of the partner;the weak coordination of community care activities between the central office of the health zone;the FOSA and the community worker: low interest in community care evidenced by weak accountability of FOSAs, community and program providers in this regard;that relates to community activities;coordination of care between care units;overload of the staff in charge of activities within the health structure and their low motivation;the low communication time devoted to people living with HIV in the FOSAs. Conclusion: The study shows that interventions that can improve the quality and outcomes of prevention of mother-to-child transmission of HIV (PMTCT) services can be directly linked to the program itself, as well as come from another or the community, which generally remains the weak link in which efforts are even less noticeable, at least as far as PMTCT is concerned. Integrating care data for the mother-child couple improve the continuum of services between the different care units as well as the quality of data management.
文摘Microplastics (MPs) have been an emerging concern due to their harmful effects on the ecosystem and are ubiquitous in various habitats, from marine to terrestrial environments. However, studies on the presence of MPs in recreational areas are limited. One of the previous works has reported that urban recreational parks are considered “sinks” for plastic debris, including MPs. In this study, low-density MPs (LD-MPs) in soil samples collected from recreational parks of Al Ain, United Arab Emirates (UAE) were isolated by density flotation method. Results showed that these parks have varying levels of LD-MPs caused by various anthropogenic activities, such as sludge use and application of reclaimed water from wastewater treatment facilities in those areas. These plastic particles were isolated in 87% of the soil samples, with an average concentration of 1550 ± 340 MPs/kg. Predominantly, these comprised large LD-MPs (300 - 5000 μm), with red and blue being the most common colors. Fourier transform infrared (FTIR) spectroscopy identified possible synthetic polymers, including polyethylene and polypropylene. Additionally, a negative correlation was observed between LD-MP concentration and soil pH and moisture content, indicating potential adverse effects on soil health. These findings highlight the need for monitoring and managing microplastic pollution in urban recreational areas to mitigate its ecological impacts.
文摘This study describes the bio-ecology of local Anopheles vectors, their abundance, type and vectoral competence in three communities around Kumasi Metropolis. The study sites were selected based on bio-ecologic zones （urban, peri-urban and rural） which influence habitat and behavior. Pyrethrum spray catch was used in the collection of indoor resting mosquitoes from bedrooms of study communities （June-August 2008）. The identification of mosquitoes was based on morphological keys earlier described. The blood meal taken and the stage of digestion and egg development were also observed. A total of 293 mosquitoes were collected and 50.5% were A. gambiae s.I. Of the three bio-ecologic zones： urban, 53.4% were A. gambiae s.l, 27.2% Culex and 19.4% Mansonia; peri-urban, 58% A. gambiae s. 1 and 42% Culex pipien s. 1 and rural, 40.2% A. gambiae s. 1, and 58.8% Culex sp respectively. About 96.6% of all mosquitoes collected had taken blood meals, with 50% of these being Anopheles gambiae s.I. Our findings indicate that urban rather exhibits rural characteristics and can best be described as ＂urban poor＂. However, more data need to be collected to ascertain this. The anopheline mosquitoes in the study communities are highly endophillic and anthropophagic and thus have high vectoral competence. The authors recommend frequent mosquito surveillance to avert malaria epidemic.
文摘Globally, one of the most devastating diseases of sorghum is anthracnose incited by Colletotrichum sublineola. During the 2019 and 2020 growing seasons, 94 and 64 accessions from the Ethiopian sorghum germplasm collection maintained by the National Genetic Resources Program of the United States Department of Agriculture were evaluated for anthracnose resistance. Seeds were planted in 1.8 m rows with 0.9 m row spacing in a randomized complete block design. The accessions and checks were replicated three times and 30 days after planting, inoculated by placing C. sublineola-colonized grains in the plant whorls. A total of 30 accessions, including PI533918, PI533923, PI534131 and PI534151 were resistant to the disease in both years. These identified resistant sources can be used in breeding programs to develop anthracnose-resistant lines and hybrids.
文摘Globally,there have been multiple public health emergencies in recent decades.High rates of morbidity,occasionally mortality,and economic instability are usually associated with pandemics.One of the epidemics that has significantly increased morbidity and mortality worldwide is the human immunodeficiency virus(HIV)and acquired immune deficiency syndrome(AIDS)pandemic.HIV has a disproportionately negative impact on key populations.Strong leadership,effective communication,and sound science are necessary for public health emergency(PHE)responses to be successful.These three PHE response pllars are also essential for bridging the HIV response gap among key populations in the setting of restrictive laws.In this review,we explored the importance of these three pillars of successful PHEs responses,and how they are essential to closing the gap in the HIV response among key populations.Leaders must make decisions and instil a sense of authority in the populace during PHEs to foster trust and confidence.Leaders should base their choices on scientific evidence.Effective communication during PHEs should be proactive,polite,imaginative,innovative,and constructive.To address gaps in the HIV response among key populations,leaders must create a supportive environment for effective communication and scientific research,communication should be used to raise awareness of HIV and to dispel stigma and discrimination,while science should provide evidence of efficacy and effectiveness of interventions amongkey populations.
文摘This study explores the mathematical practices embedded in the cultural traditions of the Tharu community, with a focus on their counting systems, measuring techniques, and modeling patterns. Through ethnographic observations and field interviews, the research reveals how the Tharu people employ a base-20 counting system influenced by the Nepali numbering system and use physical objects for arithmetic operations. Their traditional measuring techniques rely on body-referenced units such as the Haat (hand) and Anguli (finger) for length, along with culturally specific units like the Muthi and Lota for volume. Additionally, the study examines the geometric patterns found in Tharu crafts, highlighting the community’s application of symmetry and ratios. The findings illustrate the significance of these ethnomathematical practices in the daily life of the Tharu people, offering insight into how indigenous mathematical knowledge can enrich the broader understanding of mathematics education. This research contributes to the field of ethnomathematics by documenting and analyzing the ways in which cultural groups integrate mathematical concepts to solve practical problems and preserve their heritage.
文摘Air quality was measured inside 628 United Arab Emirates (UAE) personal residences. Weekly average concentrations of carbon monoxide (CO), formaldehyde (HCHO), hydrogen sulfide (H2S), nitrogen dioxide (NO2), sulfur dioxide (SO2), and three size fractions of particulate matter (PM2.5, PMc, and PM10) were determined in each home. In a subset of the homes, measurements of outdoor air quality, ultrafine PM concentrations, and elemental PM concentrations were also made. Questionnaires were administered to obtain information on housing demographics and lifestyle habits. Air measurements were performed using simple and cost effective passive samplers. The 90th percentiles of indoor CO, HCHO, H2S, NO2, and SO2 were 1.55 ppm, 0.05 ppm, 0.12 ppm, 0.01 ppm, and 0.05 ppm, respectively. Median indoor PM2.5, PMc, and PM10, concentrations were 5.73 μg/m3, 29.4 μg/m3, and 35.2 μg/m3, respectively. The median indoor concentration of ultrafine PM was 3.62 × 1010 particles/m3. Indoor/outdoor ratios for PM were 0.44, 0.41, and 0.38 for ultrafine PM, PM2.5, and PM10, respectively. These values fall within the range of other indoor air studies findings conducted in developing countries. Air conditioning, smoking, and attached kitchens were significantly correlated with indoor levels of carbon monoxide. In addition, indoor concentrations of PM2.5 and PM10 were significantly correlated with vehicles parked within five meters of the home, central air conditioning, and having attached kitchens. This is the first robust indoor air quality data set developed for the UAE. This study demonstrates that screening level tools are a good initial step for assessing air quality when logistical issues (distance, language, cultural, training) and intrusion into personal lives need to be minimized.
基金United Arab Emirates University,Grant/Award Number:12R104 and 12R121。
文摘Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fi-brosis,which appears to be a leading cause of cardiovascular diseases.Cardiac fi-brosis is characterized by the accumulation of extracellular matrix proteins,mainly collagen in the cardiac interstitium.Many experimental studies have demonstrated that fibrotic injury in the heart is reversible;therefore,it is vital to understand differ-ent molecular mechanisms that are involved in the initiation,progression,and resolu-tion of cardiac fibrosis to enable the development of antifibrotic agents.Of the many experimental models,one of the recent models that has gained renewed interest is isoproterenol(ISP)-induced cardiac fibrosis.ISP is a synthetic catecholamine,sympa-thomimetic,and nonselectiveβ-adrenergic receptor agonist.The overstimulated and sustained activation ofβ-adrenergic receptors has been reported to induce biochemi-cal and physiological alterations and ultimately result in cardiac remodeling.ISP has been used for decades to induce acute myocardial infarction.However,the use of low doses and chronic administration of ISP have been shown to induce cardiac fibrosis;this practice has increased in recent years.Intraperitoneal or subcutaneous ISP has been widely used in preclinical studies to induce cardiac remodeling manifested by fibrosis and hypertrophy.The induced oxidative stress with subsequent perturbations in cellular signaling cascades through triggering the release of free radicals is consid-ered the initiating mechanism of myocardial fibrosis.ISP is consistently used to induce fibrosis in laboratory animals and in cardiomyocytes isolated from animals.In recent years,numerous phytochemicals and synthetic molecules have been evaluated in ISP-induced cardiac fibrosis.The present review exclusively provides a comprehensive summary of the pathological biochemical,histological,and molecular mechanisms of ISP in inducing cardiac fibrosis and hypertrophy.It also summarizes the application of this experimental model in the therapeutic evaluation of natural as well as syn-thetic compounds to demonstrate their potential in mitigating myocardial fibrosis and hypertrophy.
基金supported by research grants from the United Arab Emirates University[Grant#:G00003388,G00002809,G00003627,31M374].
文摘Background:Diabetes mellitus(DM),a metabolic disorder that leads to chronic hyperglycemia,is one of the topmost global public health concerns according to the International Diabetes Federation.Adropin is a peptide hormone that is primarily involved in energy homeostasis,but its involvement in other biological activities such as lowering hyperlipidemia,and diminishing insulin resistance has also been reported.In this study,we aimed to explore additional effects of adropin on oxidative stress,inflammation,and cell proliferation in an animal model of type 1 DM.Methods:To achieve our aim,normal and diabetic Wistar rats were treated with adropin(2.1μg/kg/day)for a period of 10 days.Pancreatic tissue samples were collected for histomorphological analysis and inflammation assay,while blood was collected for oxidative stress assay.Results:Our results showed that diabetes induction stimulated cell proliferation in both exocrine and endocrine pancreas,and adropin dramatically attenuated this effect in pancreatic exocrine tissue,but not in the islet of Langerhans.In addition,adropin significantly increased glutathione reductase expression in pancreatic tissue,and augmented serum total glutathione in the diabetic rats compared to diabetic untreated rats.Conclusion:Our study indicates the potential role of adropin in alleviating oxidative stress in DM.
