Due to the impoundment of the Yangtze River, the Three Gorges Dam in China fosters high land-use dynamics. Soil erosion is expected to increase dramatically. One of the key factors in soil erosion control is the veget...Due to the impoundment of the Yangtze River, the Three Gorges Dam in China fosters high land-use dynamics. Soil erosion is expected to increase dramatically. One of the key factors in soil erosion control is the vegetation cover and crop type. However, determining these factors adequately for the use in soil erosion modeling is very time-consuming especially for large mountainous areas, such as the Xiangxi （香溪） catchment in the Three Gorges area. In our study, the crop and management factor C was calculated using the fractional vegetation cover （CFvc） based on Landsat-TM images from 2005, 2006, and 2007 and on literature studies （CLIT）. In 2007, the values of CFvc range between 0.001 and 0.98 in the Xiangxi catchment. The mean CFVC value is 0.05. CLIT values are distinctly higher, ranging from 0.08 to 0.46 with a mean value of 0.32 in the Xiangxi catchment. The mean potential soil loss amounts to 120.62 t/ha/a in the Xiangxi catchment when using CLIT for modeling. Based on CFVC, the predicted mean soil loss in the Xiangxi catchment is 11.50 t/ha/a. Therefore, CLIT appears to bemore reliable than the C factor based on the fractional vegetation cover.展开更多
Several factors may contribute to on-going challenges for spatial planning and policy in megacities such as Rome, including rapid population shifts, poorly organized areas, and lack of data through which monitoring ur...Several factors may contribute to on-going challenges for spatial planning and policy in megacities such as Rome, including rapid population shifts, poorly organized areas, and lack of data through which monitoring urban growth and land use change. This research was conducted to examine past and current effects of the urbanization process, occurred over the large Roman urban system, on the basis of multi-source and multi-temporal optical remote sensing (RS) data, collected between 1990 and 2013. These changes were then validated via Geographic Information System (GIS) techniques, in a particular procedure applied to urban land/agricultural transformations. The proposed approach, based on geo-statistical methods, was used to calculate the index of innovative space (AP Index), useful for the monitoring of the urban sprawl phenomenon. Strong evidence of urban expansion over the north-eastern quarter of the city, accompanied by environmental degradation and loss of biodiversity, is provided. Urban infill developments are expected to emerge in the south-eastern areas too, and these might increase urban pressure as well. In conclusion, RS and GIS technologies together with ancillary data can be used to assist decision makers in preparing future plans to find out appropriate solutions to urbanization encroachment.展开更多
Situations of heavy and congested traffic in urban areas have been analysed by using a statistical approach based on both the identification of specific locations that attract drivers in a multipoint-to-multipoint tra...Situations of heavy and congested traffic in urban areas have been analysed by using a statistical approach based on both the identification of specific locations that attract drivers in a multipoint-to-multipoint traffic structure and their classification (attractor’s value) as a function of the number of people visiting them by car in different time ranges. By using a Kernel Density Estimation (KDE) function, attractors’ distribution density values have been estimated and then integrated with nodal and critical traffic points and traffic density in a “congestion” map. Finally, cross-comparing congestion values with the location of buildings, the road network and the Corine Land Use/Land Cover environmental classification, a “Quality of Life” map has been generated. The authors use this term because the congestion of traffic flows, with all the problems that it entails (such as long travel time, air and acoustic pollution, and so on) is a good indicator of the quality of life, especially in small towns. Results show that this type of “off-line” analysis would allow administrators to identify, quickly and at low cost, areas where citizens’ quality of life is most affected by traffic noise and jumps and, hence, to focus costly ground measurements and interventions primarily there.展开更多
Traffic flows form a complex system, especially in the context of urban sprawl. Direct estimation of traffic flows requires significant efforts and knowing in advance where to focus the study and where to place tools ...Traffic flows form a complex system, especially in the context of urban sprawl. Direct estimation of traffic flows requires significant efforts and knowing in advance where to focus the study and where to place tools to directly measure traffic flows, and consequently traffic congestion could lead to significant savings in time and money. In the case of Rome municipality, we have monitored a situation in which a very high rate of urban fragmentation has occurred in the last 30 years, making the direct estimation of traffic difficult. The work described here can help to solve the problem of estimating traffic flows and in particular the congestion phenomenon through a very cheap approach by using remote sensing and geographical information system technology. This method is based on the identification of attractor points that draw traffic flows such as malls, schools, offices, shops, etc. that is to say, points in a territory that attract a certain number of people with vehicles (estimated with a scale) in specific periods of the day. The identification of those points and the calculation of the urban density through the satellite image processing have allowed the creation of a congestion map for the study area. Then the road network and the buildings have been classified according to the congestion values. The results highlight the most critical and congested areas that affect the traffic flows and impact the quality of life.展开更多
Based on the continuation of our past study, the present analysis is conducted to examine recent effects of the urbanization process occurring over the entire district of Rome. Overlays of ALOS AVNIR-2 and SENTINEL-2A...Based on the continuation of our past study, the present analysis is conducted to examine recent effects of the urbanization process occurring over the entire district of Rome. Overlays of ALOS AVNIR-2 and SENTINEL-2A satellite images, collected over a 6 years period, were validated via Geographic Information System (GIS) techniques, in a particular procedure applied to urban land and agricultural transformations. The use of Copernicus SENTINEL-2A imagery has improved the previous results on urban processes, by reducing the uncertainty of the discrimination of land cover classes and facilitating the photo-interpretation. Statistical analysis was performed via the Urban Area Profile index in order to quantify the sprawl phenomenon, by defining several landscape metrics. This work, to be enriched in the future by means of complementary information available from Copernicus radar sensors, like the one onboard Sentinel-1, completes the series of observations on land use published by the Italian National Institute for Environmental Protection and Research, which stopped back in 2008.展开更多
The recent Nature Water article,“To Solve Climate Change,We Need to Restore Our Sponge Planet,”by Kongjian Yu,Erica Gies,and Warren W.Wood[1],makes a compelling case for recalibrating climate strategies to prioritiz...The recent Nature Water article,“To Solve Climate Change,We Need to Restore Our Sponge Planet,”by Kongjian Yu,Erica Gies,and Warren W.Wood[1],makes a compelling case for recalibrating climate strategies to prioritize the water cycle alongside reducing carbon emissions.The authors highlight how human activities-agriculture,urbanization,and industrialization-have degraded 75%of the earth’s land,severely disrupting natural water systems.This degradation diminishes the planet’s capacity to regulate temperature through water vapor,cloud formation,and the hydrological cycle,further accelerating climate instability.展开更多
Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to ...Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC.展开更多
基金supported by the Federal German Ministry of Education and Research (BMBF) (No. 03 G 0669)coordinated by the German Jülich Research Centre (FZJ)
文摘Due to the impoundment of the Yangtze River, the Three Gorges Dam in China fosters high land-use dynamics. Soil erosion is expected to increase dramatically. One of the key factors in soil erosion control is the vegetation cover and crop type. However, determining these factors adequately for the use in soil erosion modeling is very time-consuming especially for large mountainous areas, such as the Xiangxi （香溪） catchment in the Three Gorges area. In our study, the crop and management factor C was calculated using the fractional vegetation cover （CFvc） based on Landsat-TM images from 2005, 2006, and 2007 and on literature studies （CLIT）. In 2007, the values of CFvc range between 0.001 and 0.98 in the Xiangxi catchment. The mean CFVC value is 0.05. CLIT values are distinctly higher, ranging from 0.08 to 0.46 with a mean value of 0.32 in the Xiangxi catchment. The mean potential soil loss amounts to 120.62 t/ha/a in the Xiangxi catchment when using CLIT for modeling. Based on CFVC, the predicted mean soil loss in the Xiangxi catchment is 11.50 t/ha/a. Therefore, CLIT appears to bemore reliable than the C factor based on the fractional vegetation cover.
文摘Several factors may contribute to on-going challenges for spatial planning and policy in megacities such as Rome, including rapid population shifts, poorly organized areas, and lack of data through which monitoring urban growth and land use change. This research was conducted to examine past and current effects of the urbanization process, occurred over the large Roman urban system, on the basis of multi-source and multi-temporal optical remote sensing (RS) data, collected between 1990 and 2013. These changes were then validated via Geographic Information System (GIS) techniques, in a particular procedure applied to urban land/agricultural transformations. The proposed approach, based on geo-statistical methods, was used to calculate the index of innovative space (AP Index), useful for the monitoring of the urban sprawl phenomenon. Strong evidence of urban expansion over the north-eastern quarter of the city, accompanied by environmental degradation and loss of biodiversity, is provided. Urban infill developments are expected to emerge in the south-eastern areas too, and these might increase urban pressure as well. In conclusion, RS and GIS technologies together with ancillary data can be used to assist decision makers in preparing future plans to find out appropriate solutions to urbanization encroachment.
文摘Situations of heavy and congested traffic in urban areas have been analysed by using a statistical approach based on both the identification of specific locations that attract drivers in a multipoint-to-multipoint traffic structure and their classification (attractor’s value) as a function of the number of people visiting them by car in different time ranges. By using a Kernel Density Estimation (KDE) function, attractors’ distribution density values have been estimated and then integrated with nodal and critical traffic points and traffic density in a “congestion” map. Finally, cross-comparing congestion values with the location of buildings, the road network and the Corine Land Use/Land Cover environmental classification, a “Quality of Life” map has been generated. The authors use this term because the congestion of traffic flows, with all the problems that it entails (such as long travel time, air and acoustic pollution, and so on) is a good indicator of the quality of life, especially in small towns. Results show that this type of “off-line” analysis would allow administrators to identify, quickly and at low cost, areas where citizens’ quality of life is most affected by traffic noise and jumps and, hence, to focus costly ground measurements and interventions primarily there.
文摘Traffic flows form a complex system, especially in the context of urban sprawl. Direct estimation of traffic flows requires significant efforts and knowing in advance where to focus the study and where to place tools to directly measure traffic flows, and consequently traffic congestion could lead to significant savings in time and money. In the case of Rome municipality, we have monitored a situation in which a very high rate of urban fragmentation has occurred in the last 30 years, making the direct estimation of traffic difficult. The work described here can help to solve the problem of estimating traffic flows and in particular the congestion phenomenon through a very cheap approach by using remote sensing and geographical information system technology. This method is based on the identification of attractor points that draw traffic flows such as malls, schools, offices, shops, etc. that is to say, points in a territory that attract a certain number of people with vehicles (estimated with a scale) in specific periods of the day. The identification of those points and the calculation of the urban density through the satellite image processing have allowed the creation of a congestion map for the study area. Then the road network and the buildings have been classified according to the congestion values. The results highlight the most critical and congested areas that affect the traffic flows and impact the quality of life.
文摘Based on the continuation of our past study, the present analysis is conducted to examine recent effects of the urbanization process occurring over the entire district of Rome. Overlays of ALOS AVNIR-2 and SENTINEL-2A satellite images, collected over a 6 years period, were validated via Geographic Information System (GIS) techniques, in a particular procedure applied to urban land and agricultural transformations. The use of Copernicus SENTINEL-2A imagery has improved the previous results on urban processes, by reducing the uncertainty of the discrimination of land cover classes and facilitating the photo-interpretation. Statistical analysis was performed via the Urban Area Profile index in order to quantify the sprawl phenomenon, by defining several landscape metrics. This work, to be enriched in the future by means of complementary information available from Copernicus radar sensors, like the one onboard Sentinel-1, completes the series of observations on land use published by the Italian National Institute for Environmental Protection and Research, which stopped back in 2008.
文摘The recent Nature Water article,“To Solve Climate Change,We Need to Restore Our Sponge Planet,”by Kongjian Yu,Erica Gies,and Warren W.Wood[1],makes a compelling case for recalibrating climate strategies to prioritize the water cycle alongside reducing carbon emissions.The authors highlight how human activities-agriculture,urbanization,and industrialization-have degraded 75%of the earth’s land,severely disrupting natural water systems.This degradation diminishes the planet’s capacity to regulate temperature through water vapor,cloud formation,and the hydrological cycle,further accelerating climate instability.
基金funded by Innovent biologics,Inc.Eli Lilly and Companypartly supported by China National Major Project for New Drug Innovation(2017ZX09304015).
文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC.
