The authors employed inappropriate search keywords and strategies in their published bibliometric papers within volume 29 of the World Journal of Gastroenterology.The comment highlights the identified issues,provides ...The authors employed inappropriate search keywords and strategies in their published bibliometric papers within volume 29 of the World Journal of Gastroenterology.The comment highlights the identified issues,provides evidence,and suggests improved study methodologies.Subsequent results with more appro-priate search strategies were presented to address the shortcomings.展开更多
The excessive buildup of neurotoxicα-synuclein plays a pivotal role in the pathogenesis of Parkinson's disease,highlighting the urgent need for innovative therapeutic strategies to promoteα-synuclein clearance,p...The excessive buildup of neurotoxicα-synuclein plays a pivotal role in the pathogenesis of Parkinson's disease,highlighting the urgent need for innovative therapeutic strategies to promoteα-synuclein clearance,particularly given the current lack of disease-modifying treatments.The glymphatic system,a recently identified perivascular fluid transport network,is crucial for clearing neurotoxic proteins.This review aims to synthesize current knowledge on the role of the glymphatic system inα-synuclein clearance and its implications for the pathology of Parkinson's disease while emphasizing potential therapeutic strategies and areas for future research.The review begins with an overview of the glymphatic system and details its anatomical structure and physiological functions that facilitate cerebrospinal fluid circulation and waste clearance.It summarizes emerging evidence from neuroimaging and experimental studies that highlight the close correlation between the glymphatic system and clinical symptom severity in patients with Parkinson's disease,as well as the effect of glymphatic dysfunction onα-synuclein accumulation in Parkinson's disease models.Subsequently,the review summarizes the mechanisms of glymphatic system impairment in Parkinson's disease,including sleep disturbances,aquaporin-4 impairment,and mitochondrial dysfunction,all of which diminish glymphatic system efficiency.This creates a vicious cycle that exacerbatesα-synuclein accumulation and worsens Parkinson's disease.The therapeutic perspectives section outlines strategies for enhancing glymphatic activity,such as improving sleep quality and pharmacologically targeting aquaporin-4 or its subcellular localization.Promising interventions include deep brain stimulation,melatonin supplementation,γ-aminobutyric acid modulation,and non-invasive methods(such as exercise and bright-light therapy),multisensoryγstimulation,and ultrasound therapy.Moreover,identifying neuroimaging biomarkers to assess glymphatic flow as an indicator ofα-synuclein burden could refine Parkinson's disease diagnosis and track disease progression.In conclusion,the review highlights the critical role of the glymphatic system inα-synuclein clearance and its potential as a therapeutic target in Parkinson's disease.It advocates for further research to elucidate the specific mechanisms by which the glymphatic system clears misfoldedα-synuclein and the development of imaging biomarkers to monitor glymphatic activity in patients with Parkinson's disease.Findings from this review suggest that enhancing glymphatic clearance is a promising strategy for reducingα-synuclein deposits and mitigating the progression of Parkinson's disease.展开更多
Myalgic encephalomyelitis/chronic fatigue syndrome-an insidious disease:The recent COVID-19 pandemic has brought substantial attention to the overlapping symptoms between long COVID and myalgic encephalomyelitis/chron...Myalgic encephalomyelitis/chronic fatigue syndrome-an insidious disease:The recent COVID-19 pandemic has brought substantial attention to the overlapping symptoms between long COVID and myalgic encephalomyelitis/chronic fatigue syndrome(ME/CFS),a chronic and poorly understood neurological disorder(Shankar et al.,2024).展开更多
Using multi-source reanalysis data,this study examines the relationship between the tropical Pacific-Atlantic SST Dipole Mode(TPA-DM)and summer precipitation in North China(NCSP)on the interannual timescale during the...Using multi-source reanalysis data,this study examines the relationship between the tropical Pacific-Atlantic SST Dipole Mode(TPA-DM)and summer precipitation in North China(NCSP)on the interannual timescale during the period of 1979-2022.The results show that the TPA-DM,the dominant pattern of interannual variability in the tropical Pacific and Atlantic regions,exhibits a significant negative correlation with NCSP.The positive phase of TPA-DM induces subsidence over the Maritime Continent through a zonal circulation pattern,which initiates a Pacific-Japan-like wave train along the East Asian coast.The circulation anomalies lead to moisture deficits and convergence subsidence over North China,leading to below-normal rainfall.Further analysis reveals that cooler SST in the Southern Tropical Atlantic facilitates the persistence of the TPA-DM by stimulating the anomalous Walker circulation associated with wind-evaporation-SST-convection feedback.展开更多
Natural product(NPT)derived from traditional Chinese medicine has a rich history as an integral part of Chinese healthcare for thousands of years.Recently,the application of NPT in sonodynamic antibacterial therapy(SD...Natural product(NPT)derived from traditional Chinese medicine has a rich history as an integral part of Chinese healthcare for thousands of years.Recently,the application of NPT in sonodynamic antibacterial therapy(SDAT)has emerged as a promising area of research.This perspective summarizes the recent NPT-based sonosensitizers in SDAT.Currently,common NPT-based sonosensitizers include curcumin,chlorophyll derivatives,hypericin,and berberine.Compared with other sonosensitizers,natural sources of NPT-based sonosensitizers with reactive oxide species production performance under ultrasound conditions,low biotoxicity,and other additional biological activity make them have application prospects in bacterial removal.Finally,the potential benefits and challenges of NPT-based nanosonosensitizers were also discussed.展开更多
Undesired ice accumulation on infrastructure and transportation systems leads to catastrophic events and significant economic losses.Although various anti-icing surfaces with photothermal effects can initially prevent...Undesired ice accumulation on infrastructure and transportation systems leads to catastrophic events and significant economic losses.Although various anti-icing surfaces with photothermal effects can initially prevent icing,any thawy droplets remaining on the horizontal surface can quickly re-freezing once the light diminishes.To address these challenges,we have developed a self-draining slippery surface(SDSS)that enables the thawy droplets to self-remove on the horizontal surface,thereby facilitating real-time anti-icing with the aid of sunlight(100 m W cm^(-2)).This is achieved by sandwiching a thin pyroelectric layer between slippery surface and photothermal film.Due to the synergy between the photothermal and pyroelectric layers,the SDSS not only maintains a high surface temperature of 19.8±2.2℃at the low temperature(-20.0±1.0℃),but also generates amount of charge through thermoelectric coupling.Thus,as cold droplets dropped on the SDSS,electrostatic force pushes the droplets off the charged surface because of the charge transfer mechanism.Even if the surface freezes overnight,the ice can melt and drain off the SDSS within 10 min of exposure to sunlight at-20.0±1.0℃,leaving a clean surface.This work provides a new perspective on the anti-icing system in the real-world environments.展开更多
Objective To evaluate a four-hour life-skills-based HIV/AIDS prevention curriculum among 5th grade students in rural primary schools of Hainan province.Methods The study included two stages.Stage one （September 2006-...Objective To evaluate a four-hour life-skills-based HIV/AIDS prevention curriculum among 5th grade students in rural primary schools of Hainan province.Methods The study included two stages.Stage one （September 2006-May 2007） was a pre-post-quasi experimental design;a total of 2 413 students aged 9 to 14 years from fifth grade classes of nine primary schools completed a baseline survey （1 720 students were in the intervention group,693 in the control group）,and over 98% of them took part in a short survey.The experimental curriculum was provided to the intervention group.At stage two （September 2008）,a cross-sectional questionnaire was administered to 6 923 students in 7th grade classes of eight middle schools in the same study sites.There were 1 437 students in the intervention group when the curriculum was conducted.Results Students tended to score higher in areas of HIV/AIDS related knowledge and attitudes,if they were younger than average,lived in the county seat,had access to the internet,and their parents had completed higher levels of education.Path analysis showed that,after controlling for characteristics such as family and community factors,the total effects of curriculum on knowledge in the short-term model increased remarkably compared with the baseline,and maintained major contributions to knowledge in the mid-term model.The positive effect of knowledge on attitudes was significantly improved in the short-term model as well.Conclusion A life-skills based curriculum can improve HIV/AIDS related knowledge and self-perceived level of life-skills among primary school students in rural areas in a short time,and these positive effects can still be observed at least 2 years post participation in the curriculum.展开更多
Introduction: The transition from primary to secondary school is a period when physical activity (PA) declines. Interventions delivered during curriculum time have had limited impact on PA. The after-school period may...Introduction: The transition from primary to secondary school is a period when physical activity (PA) declines. Interventions delivered during curriculum time have had limited impact on PA. The after-school period may offer a valuable opportunity to increase children’s PA. In order to identify how best to implement after-school PA interventions for older primary school children, more information regarding the provision of after-school clubs is required. This paper examined the current after-school club provision of English primary schools. Methods: All state-funded primary schools in England (n = 15,307) were sent an online questionnaire in two phases during 2013. Schools were asked about the active and non-active after-school clubs on offer to year 5 and year 6 pupils and the days on which they run, the number of children attending each after-school club, who funds the club and who leads the club. Results: Responding schools (501) were reasonably representative of the national profile. Of the 2413 clubs reported, more non-active than active clubs (5.3 vs. 4.8 per school) were described. Football was the most frequently reported activity (offered by 79.5% of schools), with netball and dance being offered by 45.3% and 44.1% of schools, respectively. A high proportion of clubs was funded by schools or parents (88.6%) and more than 40% were led by external parties. Conclusions: A number of PA programmes are provided after-school but current provision is dominated by team sports and thus, there is a need for non-sport specific PA clubs. Furthermore, there is a need to find cost-effective methods of delivering after-school PA programmes.展开更多
Objective:This cross-sectional study examined environmental correlates of sedentary behavior(SB) and physical activity(PA) in preschool children in the urban area of Tianjin,China.Methods:Data were collected from the ...Objective:This cross-sectional study examined environmental correlates of sedentary behavior(SB) and physical activity(PA) in preschool children in the urban area of Tianjin,China.Methods:Data were collected from the Physical Activity and Health in Tianjin Chinese Children study,involving healthy children 3-6 years old and their families.In all children(n=980),leisure-time SB(LTSB) and leisure-time PA(LTPA) were reported in min/day by parents.In a subgroup(n=134),overall sedentary time,light PA,and moderate-to-vigorous PA(MVP A) were objectively measured using ActiGraph accelerometry(>3 days,>10 h/day).Environmental correlates were collected using a questionnaire that included home and neighborhood characteristics(e.g.,traffic safety,presence of physical activity facilities) and children’s behaviors.Potential correlates were identified using linear regression analysis.Results:Multiple linear regression analysis showed that "having grandparents as primary caregivers"(βs and 95% confidence intervals(95%CIs)for overall sedentary time:29.7(2.1-57.2);LTSB(In):0.19(0.11-0.28)) and "having a television(for LTSB(In):0.13(0.00-0.25)) or computer(for LTSB(ln):0.13(0.03-0.23) in the child’ s bedroom" were both associated with higher SB.Furthermore, "having grandparents as primary caregivers" was associated with less MVPA(β(95%CI):-7.6(-14.1 to-1.2)),and "active commuting to school by walking" correlated with more MVPA(β(95%CI):9.8(2.2-17.4)).The path model showed that "more neighborhood PA facilities close to home" was indirectly related to higher LTPA(In),which was partly mediated by "outdoor play"(path coefficients(95%CI):0.005(0.002-0.008)) and "going to these facilities more often"(path coefficients(95%CI):0.013(0.008-0.01 8)).Traffic safety was not a correlate.Conclusion:Family structure and media exposure in the home maybe important factors in shaping preschoolers’ PA patterns.Built environmental correlates could indirectly influence preschoolers’ LTPA through parental help with engaging in active behaviors.展开更多
This year,the journal Chinese Journal of Natural Medicines(CJNM)celebrates its consecutive,successful 12 years of excellent publication.The journal was founded in May2003,as a product of China Pharmaceutical Universit...This year,the journal Chinese Journal of Natural Medicines(CJNM)celebrates its consecutive,successful 12 years of excellent publication.The journal was founded in May2003,as a product of China Pharmaceutical University,an internationally recognized top high education institution in China,and Chinese Pharmaceutical Association,an leading professional society in biomedical and pharmaceutical research and development.Since its inception,CJNM has devoted to outstanding and effective communications among pharmaceutical and medicinal plant scientists to promote botanical,chemical,and biological sciences re-展开更多
Background: Assessment is the systematic collection, review, and use of information about educational programs undertaken to improve teaching and learning. It ensures quality in training programmes, motivates, and dir...Background: Assessment is the systematic collection, review, and use of information about educational programs undertaken to improve teaching and learning. It ensures quality in training programmes, motivates, and directs students’ learning. Assessment is also used for verification of achievement of objectives of training, feedback to students, licencing, certification, and screening of students for advanced training. It is guided by several principles, including the aims of the assessment (why assess), who to assess, timing (when to assess), what to assess, methods (how to assess), and the criteria for determining the usefulness of the assessment. Objective: To describe the assessment methods used during clinical years of the undergraduate programme at Moi University School of Medicine (MUSOM) and determine the student’s perspectives concerning the comprehensiveness, relevance, objectivity of various assessment methods and challenges faced. Methodology: The study was carried out at MUSOM and a cross-sectional study design was employed. Ten study participants were studied using convenience sampling. Data were collected using an interview guide and was analyzed using content analysis. An informed consent was obtained from the study participants. Results: The methods used during clinical years at MUSOM for assessing knowledge and its applications include multiple-choice questions (MCQ), short answer questions (SAQ), modified essay questions (MEQ), long essay questions (LEQ), and oral exam. Whereas the methods for assessing clinical competence include long case, short cases, objective structured clinical examinations (OSCE), and logbook. Students felt that MCQs were comprehensive, objective, and relevant to the curriculum content. They reported that feedback was not provided after assessments. Conclusion: The assessment methods used at MUSOM during clinical years include MCQ, SAQ, MEQ, LEQ, Short cases, long cases, and OSCE. Students reported varied perceptions of the different assessment methods but favored MCQ and OSCE over other formats for assessing knowledge and clinical skills respectively.展开更多
From the perspective of professional accreditation,starting with the mode of education based on outcomes based education(OBE),this paper puts forward the idea of insisting on the principal role of university collabora...From the perspective of professional accreditation,starting with the mode of education based on outcomes based education(OBE),this paper puts forward the idea of insisting on the principal role of university collaboration,and taking the road of building new specialties of electronic information science and technology through collaborative innovation such as school administration,school-enterprise,production and teaching.This paper combines"new subject construction-result orientation-professional certification"into a whole,and probes into the orientation of talent training objectives,the construction of curriculum system,the construction of teaching staff,and the cooperation of educational models.A basic path for upgrading of new electronic engineering majors is explored.展开更多
The GeoChip is a glass slide containing oligonucleotide probes targeting genes that confer specific function to micro-organism. The GeoChip has been used to dissect the microbial community functional structure of envi...The GeoChip is a glass slide containing oligonucleotide probes targeting genes that confer specific function to micro-organism. The GeoChip has been used to dissect the microbial community functional structure of environmental samples. The PhyloChip is a glass slide containing oligonucleotide probes of the 16S rRNA genes and it offers tremendous potential to monitor microbial population. Below ground microbial community can be linked to the above ground plant community by the use of these Chips in a high throughput manner. This review seeks to determine the various roles of the GeoChip and the PhyloChip in soil microbial ecology studies. During biostimulation of uranium in groundwater, microbial community dynamics was linked to functional processes and in global warming studies, microbial response to functional gene structure has been possible by the use of the GeoChip. The PhyloChip, on the other hand, provides more comprehensive survey of the microbial diversity, composition and structure and are less susceptible to the influence of dominance in microbial community. Some of the concerns regarding the use of compost in agricultural soils i.e. the spread of human, animal and plant pathogens were reduced when the PhyloChip was used to monitor composting.展开更多
Global warming is unequivocal, as is manifested in three internationally known global temperature records with the global average temperature rising at a rate of 0.70-0.75℃ per 100 years during 1910-2009 [Wen et al.,...Global warming is unequivocal, as is manifested in three internationally known global temperature records with the global average temperature rising at a rate of 0.70-0.75℃ per 100 years during 1910-2009 [Wen et al., 2011]. In other words, the earth has warmed more than 0.8℃ since the Industrial Revolution. If it is true that 2℃ above pre-industrial level is a threshold of climate ＂safety＂, we will have to confront a serious situation where less than 1.2℃ warmins is oermissible in the future [Liu et al.. 2011].展开更多
Background Marijuana use among adolescents,including high school students,has been consistently reported to be associated with a high incidence of suicidal behaviours.Little empirical research has been conducted on th...Background Marijuana use among adolescents,including high school students,has been consistently reported to be associated with a high incidence of suicidal behaviours.Little empirical research has been conducted on the propensity impact of marijuana use on suicidal behaviours in Africa.Aims To assess factors associated with marijuana use and further quantify marijuana use as an associated factor of suicidal behaviours,including repeated attempted suicide,suicidal ideation and suicide planning,among high school students in Africa.Methods A cross-sectional study was conducted among 32802 school-going adolescents using the Global School-Based Student Health Survey data from 10 African countries grouped into West Africa,North Africa,South-East Africa,South Africa and East Africa subregions.Marijuana use and repeated attempted suicide were the main outcome variables.We employed double selection least absolute shrinkage and selection operator poisson regression model to assess risk factors associated with marijuana use and dominance analysis to establish ranked important and common risk factors.Inverse probability weighting poisson regression adjustment was applied to assess impact.Results The prevalence of marijuana use and repeated attempted suicide were 3.7%(95%CI:3.1 to 4.3)and 6.6%(95%CI:5.9 to 7.4),respectively.The most important risk factor for marijuana use generally across the countries and specifically in three subregions was alcohol consumption,which constituted approximately 40%of the impact.The average treatment effect on the treated(ATT)indicated that marijuana use significantly increased the risk of suicidal ideation,suicide planning and repeated attempted suicide by 12%(ATT=0.12(95%CI:0.02 to 0.22)),18%(ATT=0.18(95%CI:0.13 to 0.22))and 31%(ATT=0.31(95%CI:0.20 to 0.41)),respectively.Conclusions Marijuana use was significantly associated with suicidal behaviours(suicidal ideation,planning and repeated attempted suicide)among the students.To achieve Sustainable Development Goal 3.5(to strengthen prevention and treatment of substance abuse),school-based-based psychosocial interventions should be streamlined to adequately assess and manage marijuana use.Targeting the most dominant risk factors in this population could translate into the reduction of suicidal behaviours in countries within Africa.展开更多
In recent years,the"mania for school district houses"has disrupted the housing market and undermined education equity and class mobility,thus becoming a common concern.Most existing research focus on market ...In recent years,the"mania for school district houses"has disrupted the housing market and undermined education equity and class mobility,thus becoming a common concern.Most existing research focus on market motivations for purchasing school district houses while neglecting the connections between school district houses and cultural and social elements in the process of class reproduction.To make up for this deficiency this article introduces the neighborhood-based cultural capital theory to explore the diversified motivations,the processes of motivation formation,and the determining factors in purchasing school district houses.Reviews and analysis of interview materials revealed that while theories based on western experience can explain the basic purchasing motivations and their formation processes,there are distinct and varied purchasing motivations in China,more comprehensive and complex forms of capital exchange,and more dynamic factors that impact purchases of school district houses.Suggestions on solving the"mania for school district houses"are also presented.展开更多
AIM:To determine and evaluate the features of highly cited articles(HCAs)in the ophthalmology category in the Science Citation Index Expanded(SCI-EXPANDED)from 1991 to 2020.METHODS:The Web of Science Core Collection d...AIM:To determine and evaluate the features of highly cited articles(HCAs)in the ophthalmology category in the Science Citation Index Expanded(SCI-EXPANDED)from 1991 to 2020.METHODS:The Web of Science Core Collection documents with at least 100 citations from their publication year until December 31,2020,were evaluated as highly cited.The examined features were the distribution of yearly output and its average number of per publication,HCAs,authors,institutions,journals,and nations.The publication performance of nations and organizations was assessed using six publication indicators.The Y-index was employed to compare the research outputs of various authors.RESULTS:Publications that had cited the most references were highly published in high-impact factor journals.The United States of America came out on top across all six publication indicators,and it was home to eight of the top 10 most productive institutions.The articles written by Breivik et al(2006)and Farrar et al(2001)were highly cited and had a significant impact in 2020.The authors had a higher number of highly cited articles published as corresponding authors than as first authors.CONCLUSION:The findings of the present study highlight the current scope of global research in ophthalmology.The findings can help policy-makers and advisory groups of research centers to develop future policies.In addition,the findings can guide researchers in this field.展开更多
Main Objective: To determine the prevalence of thumb sucking habits amongst children at the KNUST Basic School. Methodology: This study was quantitative and descriptive with the design being a cross-sectional type. Th...Main Objective: To determine the prevalence of thumb sucking habits amongst children at the KNUST Basic School. Methodology: This study was quantitative and descriptive with the design being a cross-sectional type. The data was obtained from KNUST Basic School with a sample size of 200. Data was obtained through questionnaires and clinical examination. Results: Out of the 200 children studied, 19 (9.5%) were identified as thumb suckers, with a majority being females (13, 68.42%) and the rest being males (6, 31.58%). Most of the thumb suckers (47.37%) engaged in the habit due to hunger. The clinical manifestations observed among the thumb suckers included Class I malocclusion (94.7%), high arched palate (89.5%), anterior open bite (4), increased overjet (3, 15.8%), proclined maxillary incisors (4, 22.2%), linguoversion of mandibular incisors (1, 5.6%), unilateral posterior crossbite (2, 10.5%), speech changes (7, 41.2%), thinner thumb (7, 36.8%), elongated thumb (9, 47.4%), and callus formation on the thumb (2, 10.5%). Conclusion: Thumb sucking is a common oral habit which stimulates the growth of the orofacial complex from ages 0 to 3 years. The habit of thumb sucking is usually outgrown by age 3 but beyond this age, it turns out as a deleterious habit which has to be seen as such and measures put in place to stop thumb sucking.展开更多
The purpose of this study is to investigate the effect of Panoramic Virtual Reality(PVR)applied to online earth science classes on students’learning flow.To this end,a PVR learning material was made with a geology le...The purpose of this study is to investigate the effect of Panoramic Virtual Reality(PVR)applied to online earth science classes on students’learning flow.To this end,a PVR learning material was made with a geology learning site,which contains a core geologic concept contained in a high school curriculum in Korea.To this end,a PVR learning material was made at a geologic field site to provide an interactive and engaging way for students to grasp core geologic concepts according to the high school curriculum in Korea.The PVR was applied to online earth science classes with 45 high school students.In order to examine the effect of the PVR on students'learning flow,pre-post learning flow test papers were used,then matchedsample t-test analysis and students'responses were analyzed.The result shows online classes with PVR have positive effects on learning flow(p<0.05).And it was possible for the students to observe three-dimensional geologic structures effectively in online classes as in offline field trips.And the students'responded with positive feedbacks.These suggest that PVR in online classes can be used as an effective teaching method,which can improve students'flow and eventually understanding subjects.展开更多
文摘The authors employed inappropriate search keywords and strategies in their published bibliometric papers within volume 29 of the World Journal of Gastroenterology.The comment highlights the identified issues,provides evidence,and suggests improved study methodologies.Subsequent results with more appro-priate search strategies were presented to address the shortcomings.
基金supported by the National Natural Science Foundation of China,No.81971031(to ZL)the National Key Research and Development Program of China,No.2022YFE0210100(to JFC)+7 种基金the National Natural Science Foundation of China(Original Exploration Project),No.82151308(to JFC)the National Natural Science Foundation of China(Research Fund for International Senior Scientists),No.82150710558(to JFC)Science&Technology Initiative STI2030-Major Projects,No.2021ZD0203400(to JFC)Key Research and Development Program of Zhejiang Province,No.2023C03079(to JFC)Scientific Research Starting Foundation of Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine,Vision and Brain Health),No.OJQDSP2022007(to JFC)Project of State Key Laboratory of Ophthalmology,Optometry and Visual Science,Wenzhou Medical University,No.J01-20190101(to JFC)Scientific Research Starting Foundation of Wenzhou Medical University,No.QTJ12003(to JFC)Department of Science and Technology of Zhejiang Province,No.2023ZY1011(to JFC)。
文摘The excessive buildup of neurotoxicα-synuclein plays a pivotal role in the pathogenesis of Parkinson's disease,highlighting the urgent need for innovative therapeutic strategies to promoteα-synuclein clearance,particularly given the current lack of disease-modifying treatments.The glymphatic system,a recently identified perivascular fluid transport network,is crucial for clearing neurotoxic proteins.This review aims to synthesize current knowledge on the role of the glymphatic system inα-synuclein clearance and its implications for the pathology of Parkinson's disease while emphasizing potential therapeutic strategies and areas for future research.The review begins with an overview of the glymphatic system and details its anatomical structure and physiological functions that facilitate cerebrospinal fluid circulation and waste clearance.It summarizes emerging evidence from neuroimaging and experimental studies that highlight the close correlation between the glymphatic system and clinical symptom severity in patients with Parkinson's disease,as well as the effect of glymphatic dysfunction onα-synuclein accumulation in Parkinson's disease models.Subsequently,the review summarizes the mechanisms of glymphatic system impairment in Parkinson's disease,including sleep disturbances,aquaporin-4 impairment,and mitochondrial dysfunction,all of which diminish glymphatic system efficiency.This creates a vicious cycle that exacerbatesα-synuclein accumulation and worsens Parkinson's disease.The therapeutic perspectives section outlines strategies for enhancing glymphatic activity,such as improving sleep quality and pharmacologically targeting aquaporin-4 or its subcellular localization.Promising interventions include deep brain stimulation,melatonin supplementation,γ-aminobutyric acid modulation,and non-invasive methods(such as exercise and bright-light therapy),multisensoryγstimulation,and ultrasound therapy.Moreover,identifying neuroimaging biomarkers to assess glymphatic flow as an indicator ofα-synuclein burden could refine Parkinson's disease diagnosis and track disease progression.In conclusion,the review highlights the critical role of the glymphatic system inα-synuclein clearance and its potential as a therapeutic target in Parkinson's disease.It advocates for further research to elucidate the specific mechanisms by which the glymphatic system clears misfoldedα-synuclein and the development of imaging biomarkers to monitor glymphatic activity in patients with Parkinson's disease.Findings from this review suggest that enhancing glymphatic clearance is a promising strategy for reducingα-synuclein deposits and mitigating the progression of Parkinson's disease.
基金supported by the Judith Jane Mason and Harold Stannett Williams Memorial Foundation National Medical Program(#Mason2210)to JX。
文摘Myalgic encephalomyelitis/chronic fatigue syndrome-an insidious disease:The recent COVID-19 pandemic has brought substantial attention to the overlapping symptoms between long COVID and myalgic encephalomyelitis/chronic fatigue syndrome(ME/CFS),a chronic and poorly understood neurological disorder(Shankar et al.,2024).
基金jointly supported by the Second Tibetan Plateau Scientific Expedition and Research Program[grant number-ber 2019QZKK0103]the National Natural Science Foundation of China[grant number 42293294]the China Meteorological Admin-istration Climate Change Special Program[grant number QBZ202303]。
文摘Using multi-source reanalysis data,this study examines the relationship between the tropical Pacific-Atlantic SST Dipole Mode(TPA-DM)and summer precipitation in North China(NCSP)on the interannual timescale during the period of 1979-2022.The results show that the TPA-DM,the dominant pattern of interannual variability in the tropical Pacific and Atlantic regions,exhibits a significant negative correlation with NCSP.The positive phase of TPA-DM induces subsidence over the Maritime Continent through a zonal circulation pattern,which initiates a Pacific-Japan-like wave train along the East Asian coast.The circulation anomalies lead to moisture deficits and convergence subsidence over North China,leading to below-normal rainfall.Further analysis reveals that cooler SST in the Southern Tropical Atlantic facilitates the persistence of the TPA-DM by stimulating the anomalous Walker circulation associated with wind-evaporation-SST-convection feedback.
基金supported by the Innovation and Entrepreneurship Training Program for College Students(X2025102911746,X2025102910483).
文摘Natural product(NPT)derived from traditional Chinese medicine has a rich history as an integral part of Chinese healthcare for thousands of years.Recently,the application of NPT in sonodynamic antibacterial therapy(SDAT)has emerged as a promising area of research.This perspective summarizes the recent NPT-based sonosensitizers in SDAT.Currently,common NPT-based sonosensitizers include curcumin,chlorophyll derivatives,hypericin,and berberine.Compared with other sonosensitizers,natural sources of NPT-based sonosensitizers with reactive oxide species production performance under ultrasound conditions,low biotoxicity,and other additional biological activity make them have application prospects in bacterial removal.Finally,the potential benefits and challenges of NPT-based nanosonosensitizers were also discussed.
基金supported by the National Natural Science Foundation of China(52273101,51922018,and 21875011)the Fundamental Research Funds for the Central Universities(KG21015201 and KG21020801)China Postdoctoral Science Foundation(2025M77422)。
文摘Undesired ice accumulation on infrastructure and transportation systems leads to catastrophic events and significant economic losses.Although various anti-icing surfaces with photothermal effects can initially prevent icing,any thawy droplets remaining on the horizontal surface can quickly re-freezing once the light diminishes.To address these challenges,we have developed a self-draining slippery surface(SDSS)that enables the thawy droplets to self-remove on the horizontal surface,thereby facilitating real-time anti-icing with the aid of sunlight(100 m W cm^(-2)).This is achieved by sandwiching a thin pyroelectric layer between slippery surface and photothermal film.Due to the synergy between the photothermal and pyroelectric layers,the SDSS not only maintains a high surface temperature of 19.8±2.2℃at the low temperature(-20.0±1.0℃),but also generates amount of charge through thermoelectric coupling.Thus,as cold droplets dropped on the SDSS,electrostatic force pushes the droplets off the charged surface because of the charge transfer mechanism.Even if the surface freezes overnight,the ice can melt and drain off the SDSS within 10 min of exposure to sunlight at-20.0±1.0℃,leaving a clean surface.This work provides a new perspective on the anti-icing system in the real-world environments.
基金supported by Ministry of Health of China "AIDS prevention and cure application project,WA2005-11"
文摘Objective To evaluate a four-hour life-skills-based HIV/AIDS prevention curriculum among 5th grade students in rural primary schools of Hainan province.Methods The study included two stages.Stage one （September 2006-May 2007） was a pre-post-quasi experimental design;a total of 2 413 students aged 9 to 14 years from fifth grade classes of nine primary schools completed a baseline survey （1 720 students were in the intervention group,693 in the control group）,and over 98% of them took part in a short survey.The experimental curriculum was provided to the intervention group.At stage two （September 2008）,a cross-sectional questionnaire was administered to 6 923 students in 7th grade classes of eight middle schools in the same study sites.There were 1 437 students in the intervention group when the curriculum was conducted.Results Students tended to score higher in areas of HIV/AIDS related knowledge and attitudes,if they were younger than average,lived in the county seat,had access to the internet,and their parents had completed higher levels of education.Path analysis showed that,after controlling for characteristics such as family and community factors,the total effects of curriculum on knowledge in the short-term model increased remarkably compared with the baseline,and maintained major contributions to knowledge in the mid-term model.The positive effect of knowledge on attitudes was significantly improved in the short-term model as well.Conclusion A life-skills based curriculum can improve HIV/AIDS related knowledge and self-perceived level of life-skills among primary school students in rural areas in a short time,and these positive effects can still be observed at least 2 years post participation in the curriculum.
文摘Introduction: The transition from primary to secondary school is a period when physical activity (PA) declines. Interventions delivered during curriculum time have had limited impact on PA. The after-school period may offer a valuable opportunity to increase children’s PA. In order to identify how best to implement after-school PA interventions for older primary school children, more information regarding the provision of after-school clubs is required. This paper examined the current after-school club provision of English primary schools. Methods: All state-funded primary schools in England (n = 15,307) were sent an online questionnaire in two phases during 2013. Schools were asked about the active and non-active after-school clubs on offer to year 5 and year 6 pupils and the days on which they run, the number of children attending each after-school club, who funds the club and who leads the club. Results: Responding schools (501) were reasonably representative of the national profile. Of the 2413 clubs reported, more non-active than active clubs (5.3 vs. 4.8 per school) were described. Football was the most frequently reported activity (offered by 79.5% of schools), with netball and dance being offered by 45.3% and 44.1% of schools, respectively. A high proportion of clubs was funded by schools or parents (88.6%) and more than 40% were led by external parties. Conclusions: A number of PA programmes are provided after-school but current provision is dominated by team sports and thus, there is a need for non-sport specific PA clubs. Furthermore, there is a need to find cost-effective methods of delivering after-school PA programmes.
基金supported by Tianjin Medical University and the University Medical Center Groningen。
文摘Objective:This cross-sectional study examined environmental correlates of sedentary behavior(SB) and physical activity(PA) in preschool children in the urban area of Tianjin,China.Methods:Data were collected from the Physical Activity and Health in Tianjin Chinese Children study,involving healthy children 3-6 years old and their families.In all children(n=980),leisure-time SB(LTSB) and leisure-time PA(LTPA) were reported in min/day by parents.In a subgroup(n=134),overall sedentary time,light PA,and moderate-to-vigorous PA(MVP A) were objectively measured using ActiGraph accelerometry(>3 days,>10 h/day).Environmental correlates were collected using a questionnaire that included home and neighborhood characteristics(e.g.,traffic safety,presence of physical activity facilities) and children’s behaviors.Potential correlates were identified using linear regression analysis.Results:Multiple linear regression analysis showed that "having grandparents as primary caregivers"(βs and 95% confidence intervals(95%CIs)for overall sedentary time:29.7(2.1-57.2);LTSB(In):0.19(0.11-0.28)) and "having a television(for LTSB(In):0.13(0.00-0.25)) or computer(for LTSB(ln):0.13(0.03-0.23) in the child’ s bedroom" were both associated with higher SB.Furthermore, "having grandparents as primary caregivers" was associated with less MVPA(β(95%CI):-7.6(-14.1 to-1.2)),and "active commuting to school by walking" correlated with more MVPA(β(95%CI):9.8(2.2-17.4)).The path model showed that "more neighborhood PA facilities close to home" was indirectly related to higher LTPA(In),which was partly mediated by "outdoor play"(path coefficients(95%CI):0.005(0.002-0.008)) and "going to these facilities more often"(path coefficients(95%CI):0.013(0.008-0.01 8)).Traffic safety was not a correlate.Conclusion:Family structure and media exposure in the home maybe important factors in shaping preschoolers’ PA patterns.Built environmental correlates could indirectly influence preschoolers’ LTPA through parental help with engaging in active behaviors.
文摘This year,the journal Chinese Journal of Natural Medicines(CJNM)celebrates its consecutive,successful 12 years of excellent publication.The journal was founded in May2003,as a product of China Pharmaceutical University,an internationally recognized top high education institution in China,and Chinese Pharmaceutical Association,an leading professional society in biomedical and pharmaceutical research and development.Since its inception,CJNM has devoted to outstanding and effective communications among pharmaceutical and medicinal plant scientists to promote botanical,chemical,and biological sciences re-
文摘Background: Assessment is the systematic collection, review, and use of information about educational programs undertaken to improve teaching and learning. It ensures quality in training programmes, motivates, and directs students’ learning. Assessment is also used for verification of achievement of objectives of training, feedback to students, licencing, certification, and screening of students for advanced training. It is guided by several principles, including the aims of the assessment (why assess), who to assess, timing (when to assess), what to assess, methods (how to assess), and the criteria for determining the usefulness of the assessment. Objective: To describe the assessment methods used during clinical years of the undergraduate programme at Moi University School of Medicine (MUSOM) and determine the student’s perspectives concerning the comprehensiveness, relevance, objectivity of various assessment methods and challenges faced. Methodology: The study was carried out at MUSOM and a cross-sectional study design was employed. Ten study participants were studied using convenience sampling. Data were collected using an interview guide and was analyzed using content analysis. An informed consent was obtained from the study participants. Results: The methods used during clinical years at MUSOM for assessing knowledge and its applications include multiple-choice questions (MCQ), short answer questions (SAQ), modified essay questions (MEQ), long essay questions (LEQ), and oral exam. Whereas the methods for assessing clinical competence include long case, short cases, objective structured clinical examinations (OSCE), and logbook. Students felt that MCQs were comprehensive, objective, and relevant to the curriculum content. They reported that feedback was not provided after assessments. Conclusion: The assessment methods used at MUSOM during clinical years include MCQ, SAQ, MEQ, LEQ, Short cases, long cases, and OSCE. Students reported varied perceptions of the different assessment methods but favored MCQ and OSCE over other formats for assessing knowledge and clinical skills respectively.
文摘From the perspective of professional accreditation,starting with the mode of education based on outcomes based education(OBE),this paper puts forward the idea of insisting on the principal role of university collaboration,and taking the road of building new specialties of electronic information science and technology through collaborative innovation such as school administration,school-enterprise,production and teaching.This paper combines"new subject construction-result orientation-professional certification"into a whole,and probes into the orientation of talent training objectives,the construction of curriculum system,the construction of teaching staff,and the cooperation of educational models.A basic path for upgrading of new electronic engineering majors is explored.
文摘The GeoChip is a glass slide containing oligonucleotide probes targeting genes that confer specific function to micro-organism. The GeoChip has been used to dissect the microbial community functional structure of environmental samples. The PhyloChip is a glass slide containing oligonucleotide probes of the 16S rRNA genes and it offers tremendous potential to monitor microbial population. Below ground microbial community can be linked to the above ground plant community by the use of these Chips in a high throughput manner. This review seeks to determine the various roles of the GeoChip and the PhyloChip in soil microbial ecology studies. During biostimulation of uranium in groundwater, microbial community dynamics was linked to functional processes and in global warming studies, microbial response to functional gene structure has been possible by the use of the GeoChip. The PhyloChip, on the other hand, provides more comprehensive survey of the microbial diversity, composition and structure and are less susceptible to the influence of dominance in microbial community. Some of the concerns regarding the use of compost in agricultural soils i.e. the spread of human, animal and plant pathogens were reduced when the PhyloChip was used to monitor composting.
基金funded by the National Basic Research Program of China(No.2010CB950104)the Strategic Priority Research Program of the Chinese Academy of Sciences(No. 9-XDA05090104)
文摘Global warming is unequivocal, as is manifested in three internationally known global temperature records with the global average temperature rising at a rate of 0.70-0.75℃ per 100 years during 1910-2009 [Wen et al., 2011]. In other words, the earth has warmed more than 0.8℃ since the Industrial Revolution. If it is true that 2℃ above pre-industrial level is a threshold of climate ＂safety＂, we will have to confront a serious situation where less than 1.2℃ warmins is oermissible in the future [Liu et al.. 2011].
文摘Background Marijuana use among adolescents,including high school students,has been consistently reported to be associated with a high incidence of suicidal behaviours.Little empirical research has been conducted on the propensity impact of marijuana use on suicidal behaviours in Africa.Aims To assess factors associated with marijuana use and further quantify marijuana use as an associated factor of suicidal behaviours,including repeated attempted suicide,suicidal ideation and suicide planning,among high school students in Africa.Methods A cross-sectional study was conducted among 32802 school-going adolescents using the Global School-Based Student Health Survey data from 10 African countries grouped into West Africa,North Africa,South-East Africa,South Africa and East Africa subregions.Marijuana use and repeated attempted suicide were the main outcome variables.We employed double selection least absolute shrinkage and selection operator poisson regression model to assess risk factors associated with marijuana use and dominance analysis to establish ranked important and common risk factors.Inverse probability weighting poisson regression adjustment was applied to assess impact.Results The prevalence of marijuana use and repeated attempted suicide were 3.7%(95%CI:3.1 to 4.3)and 6.6%(95%CI:5.9 to 7.4),respectively.The most important risk factor for marijuana use generally across the countries and specifically in three subregions was alcohol consumption,which constituted approximately 40%of the impact.The average treatment effect on the treated(ATT)indicated that marijuana use significantly increased the risk of suicidal ideation,suicide planning and repeated attempted suicide by 12%(ATT=0.12(95%CI:0.02 to 0.22)),18%(ATT=0.18(95%CI:0.13 to 0.22))and 31%(ATT=0.31(95%CI:0.20 to 0.41)),respectively.Conclusions Marijuana use was significantly associated with suicidal behaviours(suicidal ideation,planning and repeated attempted suicide)among the students.To achieve Sustainable Development Goal 3.5(to strengthen prevention and treatment of substance abuse),school-based-based psychosocial interventions should be streamlined to adequately assess and manage marijuana use.Targeting the most dominant risk factors in this population could translate into the reduction of suicidal behaviours in countries within Africa.
基金a phased result of “The formation of youth housing ownership preference” of the Project Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministrythe “International comparison research in solving the housing issue of ‘sandwich class’ in Beijing”(No.17GLC038)of Beijing Social Science Fund for Youth Projects in 2017
文摘In recent years,the"mania for school district houses"has disrupted the housing market and undermined education equity and class mobility,thus becoming a common concern.Most existing research focus on market motivations for purchasing school district houses while neglecting the connections between school district houses and cultural and social elements in the process of class reproduction.To make up for this deficiency this article introduces the neighborhood-based cultural capital theory to explore the diversified motivations,the processes of motivation formation,and the determining factors in purchasing school district houses.Reviews and analysis of interview materials revealed that while theories based on western experience can explain the basic purchasing motivations and their formation processes,there are distinct and varied purchasing motivations in China,more comprehensive and complex forms of capital exchange,and more dynamic factors that impact purchases of school district houses.Suggestions on solving the"mania for school district houses"are also presented.
文摘AIM:To determine and evaluate the features of highly cited articles(HCAs)in the ophthalmology category in the Science Citation Index Expanded(SCI-EXPANDED)from 1991 to 2020.METHODS:The Web of Science Core Collection documents with at least 100 citations from their publication year until December 31,2020,were evaluated as highly cited.The examined features were the distribution of yearly output and its average number of per publication,HCAs,authors,institutions,journals,and nations.The publication performance of nations and organizations was assessed using six publication indicators.The Y-index was employed to compare the research outputs of various authors.RESULTS:Publications that had cited the most references were highly published in high-impact factor journals.The United States of America came out on top across all six publication indicators,and it was home to eight of the top 10 most productive institutions.The articles written by Breivik et al(2006)and Farrar et al(2001)were highly cited and had a significant impact in 2020.The authors had a higher number of highly cited articles published as corresponding authors than as first authors.CONCLUSION:The findings of the present study highlight the current scope of global research in ophthalmology.The findings can help policy-makers and advisory groups of research centers to develop future policies.In addition,the findings can guide researchers in this field.
文摘Main Objective: To determine the prevalence of thumb sucking habits amongst children at the KNUST Basic School. Methodology: This study was quantitative and descriptive with the design being a cross-sectional type. The data was obtained from KNUST Basic School with a sample size of 200. Data was obtained through questionnaires and clinical examination. Results: Out of the 200 children studied, 19 (9.5%) were identified as thumb suckers, with a majority being females (13, 68.42%) and the rest being males (6, 31.58%). Most of the thumb suckers (47.37%) engaged in the habit due to hunger. The clinical manifestations observed among the thumb suckers included Class I malocclusion (94.7%), high arched palate (89.5%), anterior open bite (4), increased overjet (3, 15.8%), proclined maxillary incisors (4, 22.2%), linguoversion of mandibular incisors (1, 5.6%), unilateral posterior crossbite (2, 10.5%), speech changes (7, 41.2%), thinner thumb (7, 36.8%), elongated thumb (9, 47.4%), and callus formation on the thumb (2, 10.5%). Conclusion: Thumb sucking is a common oral habit which stimulates the growth of the orofacial complex from ages 0 to 3 years. The habit of thumb sucking is usually outgrown by age 3 but beyond this age, it turns out as a deleterious habit which has to be seen as such and measures put in place to stop thumb sucking.
基金supported by the research grant of the Kongju National University in 2023.
文摘The purpose of this study is to investigate the effect of Panoramic Virtual Reality(PVR)applied to online earth science classes on students’learning flow.To this end,a PVR learning material was made with a geology learning site,which contains a core geologic concept contained in a high school curriculum in Korea.To this end,a PVR learning material was made at a geologic field site to provide an interactive and engaging way for students to grasp core geologic concepts according to the high school curriculum in Korea.The PVR was applied to online earth science classes with 45 high school students.In order to examine the effect of the PVR on students'learning flow,pre-post learning flow test papers were used,then matchedsample t-test analysis and students'responses were analyzed.The result shows online classes with PVR have positive effects on learning flow(p<0.05).And it was possible for the students to observe three-dimensional geologic structures effectively in online classes as in offline field trips.And the students'responded with positive feedbacks.These suggest that PVR in online classes can be used as an effective teaching method,which can improve students'flow and eventually understanding subjects.
