By 2025,research on Traditional Chinese Medicine(TCM)meridians has generated 12-15 macro-level theories and over 20 specific hypotheses,manifesting a highly fragmented research landscape.Objective:This paper proposes ...By 2025,research on Traditional Chinese Medicine(TCM)meridians has generated 12-15 macro-level theories and over 20 specific hypotheses,manifesting a highly fragmented research landscape.Objective:This paper proposes the“Holistic Hierarchical Predictive-Integration Hypothesis”(HHPIT)to construct a unified theoretical framework that integrates the rational components of existing meridian hypotheses.Methods:The HHPIT hypothesis systematically reviews current meridian theories,employs interdisciplinary methodologies,integrates artificial intelligence technology,and establishes a three-tier architecture encompassing structural,functional,and systemic layers.Results:HHPIT successfully integrates diverse meridian theories,proposes a computable algorithmic pipeline,and provides specific application protocols for chronic disease treatment,anti-aging,and enhancement of Zang-fu organ functions.Conclusion:HHPIT offers a novel,computable,and verifiable research paradigm for meridian studies,promoting the modernization and internationalization of TCM theory.展开更多
Background: Plant-based diets are eating patterns focusing on high intake of plant-basedfoods while limiting the intake of animal-based foods. In recent decades, plant-based dietshave received increasing attention for...Background: Plant-based diets are eating patterns focusing on high intake of plant-basedfoods while limiting the intake of animal-based foods. In recent decades, plant-based dietshave received increasing attention for their potential benefits for humans and theenvironment. However, a comprehensive overview of the development trends and researchhotspots of plant-based diets is still lacking. Therefore, this scientometric study aimed to fillthis critical research gap. Methods: English literature related to plant-based diets publishedfrom 2012 to 2023 in Science Citation Index Expanded (SCIE) of Web of Science CoreCollection was collected on August 16, 2023, using relevant key terms. R-bibliometrix,CiteSpace, and VOSviewer were used to analyze data and construct knowledge graphs.Results: Overall, 4135 publications (3127 articles and 1008 reviews) were included in thisstudy, showing an obvious upward trend in this field annually from 2012 to 2023, rangingfrom 70 to 921. The USA published the highest number of studies (n =1158) and was theleading research center in this field worldwide. Universities were the main researchinstitutions;particularly, Harvard T.H. Chan School of Public Health contributed to thelargest number of publications (n = 88) and had an active cooperation with otherinstitutions. Mcclements DJ contributed the most publications (n = 49) and ranked firstamong the scholars in plant-based diets. The most productive academic journal (n = 353)on plant-based diets was Nutrients, with an IF2022 of 5.9, while Foods and Frontiers in Nutritionwere the relatively active journals in this field in recent years. “Quality,” “milk,” “culturedmeat,” “plant protein,” “environmental impacts,” “functional properties,” “plant-based meatalternative,” “dietary change,” “vegan diet,” “plant-based beverage,” “gut microbiota,”“middle-income countries,” and “chronic kidney disease” were the main research hotspotsand frontiers in the field of plant-based diets. Conclusion: This study provides acomprehensive overview of global research on plant-based diets. Although research in thisfield has gained increasing attention in recent decades, cooperation among differentinstitutions and researchers should be significantly strengthened. Moreover, more studiesare needed to further assess the health and environmental impacts of plant-based diets.展开更多
Interplay between topology and magnetism can give rise to exotic properties in topological materials.Two-dimensional bismuth has been extensively studied owing to its topological states with a strong spin-orbit coupli...Interplay between topology and magnetism can give rise to exotic properties in topological materials.Two-dimensional bismuth has been extensively studied owing to its topological states with a strong spin-orbit coupling,and 1T-VTe_(2)monolayer theoretically predicted to host an intrinsic magnetism as experimentally suggested.In this work,we successfully constructed a vertical heterostructure composed of the two-dimensional Bi(110)monolayer and 1T-VTe_(2)monolayer by using molecular beam epitaxy(MBE).Scanning tunneling microscopy(STM)measurements revealed that the growth of Bi preferably occurs along the step edges of the VTe_(2)monolayer,forming a Bi(110)monolayer on top of the VTe_(2)monolayer next to a peripheral Bi bilayer.The Bi(100)/VTe_(2)heterostructure exhibits a specific lattice registry with a well-defined moiréperiodicity.Scanning tunneling spectroscopy(STS)measurements further unveiled an universal suppression in the local density-of-states at the boundary of the Bi(110)/VTe_(2)bilayer.By examining the atomic structures of Bi(110)boundaries,we found this effect does not originate from the previously proposed atomic reconstruction at the step edge of Bi(110),but is likely related to the magnetic properties of the VTe_(2)monolayer.展开更多
Coulomb drag refers to the phenomenon in which a current driven through one conducting layer induces a voltage nearby,electrically isolated layer sorely through interlayer Coulomb interactions between charge carriers....Coulomb drag refers to the phenomenon in which a current driven through one conducting layer induces a voltage nearby,electrically isolated layer sorely through interlayer Coulomb interactions between charge carriers.It has been extensively studied in various systems,including parallel nanowires,double quantum wells,and double-layer graphene.Here,we report the observation of Coulomb drag in a novel system consisting of two graphene layers separated laterally by a 30 nm gap within the material plane,exhibiting behavior distinct from that in vertical graphene heterostructures.Our experiments reveal pronounced negative drag resistances under an out-of-plane magnetic field at the quantum Hall edges,reaching a maximum when the carrier densities in both graphene layers are tuned to the charge neutrality point via gate voltages.Our work establish two separate and spatially closed quantum Hall edge modes as a new platform to explore electronic interaction physics between one dimensional systems.展开更多
The functional properties of glasses are governed by their formation history and the complex relaxation processes they undergo.However,under extreme conditions,glass behaviors are still elusive.In this study,we employ...The functional properties of glasses are governed by their formation history and the complex relaxation processes they undergo.However,under extreme conditions,glass behaviors are still elusive.In this study,we employ simulations with varied protocols to evaluate the effectiveness of different descriptors in predicting mechanical properties across both low-and high-pressure regimes.Our findings demonstrate that conventional structural and configurational descriptors fail to correlate with the mechanical response following pressure release,whereas the activation energy descriptor exhibits robust linearity with shear modulus after correcting for pressure effects.Notably,the soft mode parameter emerges as an ideal and computationally efficient alternative for capturing this mechanical behavior.These findings provide critical insights into the influence of pressure on glassy properties,integrating the distinct features of compressed glasses into a unified theoretical framework.展开更多
Objective:To investigate the potential of oral probiotics to improve sperm motility and decrease DNA fragmentation in men diagnosed with asthenozoospermia.Methods:Men diagnosed with asthenozoospermia,aged between 18 a...Objective:To investigate the potential of oral probiotics to improve sperm motility and decrease DNA fragmentation in men diagnosed with asthenozoospermia.Methods:Men diagnosed with asthenozoospermia,aged between 18 and 40 years,were randomly assigned to receive probiotic or placebo for 10 weeks.Sperm parameters(count,motility,and morphology)and seminal fluid biochemical markers were assessed using light microscopy and Diff-Quik staining.Intracellular reactive oxygen species levels were measured using the malondialdehyde(MDA)technique,while DNA fragmentation index(DFI)was evaluated through acidic aniline blue staining.Data from both groups were compared to determine the effects of probiotic supplementation.Results:Sixteen men were included.The probiotic group(n=8)showed a significant increase in total sperm motility(P<0.001)and progressive motility(P=0.003)compared to the placebo group(n=8).Additionally,sperm count in the probiotic group was significantly higher than in the placebo group,although other sperm parameters did not show significant changes.Notably,levels of MDA(P=0.027)and DFI(P=0.004)were significantly reduced in the probiotic group,indicating a decrease in oxidative stress and DNA damage.Conclusions:Probiotic supplementation effectively enhances sperm quality by mitigating oxidative stress and reducing DNA damage,thereby improving sperm motility in men with asthenozoospermia.Study registration:The trial was registered with the Iranian Registry of Clinical Trials(IRCT20220119053769N1).展开更多
Neuromorphic circuits based on superconducting tunnel junctions have attracted much attention due to their highspeed computing capabilities and low energy consumption.Josephson junction circuits can effectively mimic ...Neuromorphic circuits based on superconducting tunnel junctions have attracted much attention due to their highspeed computing capabilities and low energy consumption.Josephson junction circuits can effectively mimic biological neural dynamics.Leveraging these advantages,we construct a Josephson junction neuron-like model with a phasedependent dissipative current,referred to as a memristive current.The proposed memristive Josephson junction model exhibits complex dynamical behaviors.Furthermore,considering the effect of a fast-modulated synapse,we explore synchronization phenomena in coupled networks under varying coupling conductances and excitatory/inhibitory interactions.Finally,we extend the neuromorphic Josephson junction model—exhibiting complex dynamics—to the field of image encryption.These results not only enrich the understanding of the dynamical characteristics of memristive Josephson junctions but also provide a theoretical basis and technical support for the development of new neural networks and their applications in information security technology.展开更多
In this paper,we derive the sub-Riemannian version of the Kastler-Kalau-Walze type theorem and the Dabrowski-Sitarz-Zalecki type theorem for the twisted BCV spaces.We also compute the Connes conformal invariants for t...In this paper,we derive the sub-Riemannian version of the Kastler-Kalau-Walze type theorem and the Dabrowski-Sitarz-Zalecki type theorem for the twisted BCV spaces.We also compute the Connes conformal invariants for the twisted product,as well as the sub-Riemannian limits of the Connes conformal invariants for the twisted BCV spaces.展开更多
There is a need for accurate prediction of heat and mass transfer in aerodynamically designed,non-Newtonian nanofluids across aerodynamically designed,high-flux biomedical micro-devices for thermal management and reac...There is a need for accurate prediction of heat and mass transfer in aerodynamically designed,non-Newtonian nanofluids across aerodynamically designed,high-flux biomedical micro-devices for thermal management and reactive coating processes,but existing work is not uncharacteristically remiss regarding viscoelasticity,radiative heating,viscous dissipation,and homogeneous–heterogeneous reactions within a single scheme that is calibrated.This research investigates the flow of Williamson nanofluid across a dynamically wedged surface under conditions that include viscous dissipation,thermal radiation,and homogeneous-heterogeneous reactions.The paper develops a detailed mathematical approach that utilizes boundary layers to transform partial differential equations into ordinary differential equations using similarity transformations.RK4 is the technique for gaining numerical solutions,but with the addition of ANNs,there is an improvement in prediction accuracy and computational efficiency.The study investigates the influence of wedge angle parameter,along with Weissenberg number,thermal radiation parameter and Brownian motion parameter,and Schmidt number,on velocity distribution,temperature distribution,and concentra-tion distribution.Enhanced Weissenberg numbers enhance viscoelastic responses that modify velocity patterns,but radiation parameters and thermophoresis have key impacts on thermal transfer phenomena.This research develops findings that are of enormous application in aerospace,biomedical(artificial hearts and drug delivery),and industrial cooling technology applications.New findings on non-Newtonian nanofluids under full flow systems are included in this work to enhance heat transfer methods in novel fluid-based systems.展开更多
Advances in skeletal muscle omics has expanded our understanding of exercise-induced adaptations at the molecular level.Over the past 2 decades,transcriptome studies in muscle have detailed acute and chronic responses...Advances in skeletal muscle omics has expanded our understanding of exercise-induced adaptations at the molecular level.Over the past 2 decades,transcriptome studies in muscle have detailed acute and chronic responses to resistance,endurance,and concurrent exercise,focusing on variables such as training status,nutrition,age,sex,and metabolic health profile.Multi-omics approaches,such as the integration of transcriptomic and epigenetic data,along with emerging ribosomal RNA sequencing advancements,have further provided insights into how skeletal muscle adapts to exercise across the lifespan.Downstream of the transcriptome,proteomic and phosphoproteomic studies have identified novel regulators of exercise adaptations,while single-cell/nucleus and spatial sequencing technologies promise to evolve our understanding of cellular specialization and communication in and around skeletal muscle cells.This narrative review highlights(a)the historical foundations of exercise omics in skeletal muscle,(b)current research at 3 layers of the omics cascade(DNA,RNA,and protein),and(c)applications of single-cell omics and spatial sequencing technologies to study skeletal muscle adaptation to exercise.Further elaboration of muscle's global molecular footprint using multi-omics methods will help researchers and practitioners develop more effective and targeted approaches to improve skeletal muscle health as well as athletic performance.展开更多
The arginine-phenylalanine-amide neuropeptide receptor family comprises a subclass within the G protein-coupled receptor superfamily with crucial roles in physiological regulation.These receptors recognize and bind ne...The arginine-phenylalanine-amide neuropeptide receptor family comprises a subclass within the G protein-coupled receptor superfamily with crucial roles in physiological regulation.These receptors recognize and bind neuropeptides with an arginine-phenylalanine-amide motif,thereby participating in a variety of biological processes such as energy metabolism,pain perception,and reproductive functions.In this review,we explore the physiological and pathological processes involving these receptors and delve into the structure-activity relationships of their ligand peptides,clarifying the key structural motifs within these neuropeptides that determine their biological activity,pharmacological potency,and receptor selectivity.Particular emphasis is placed on their roles in modulating nociception,regulating appetite,and maintaining reproductive health.Additionally,we discuss the therapeutic potential of structure-based drug design targeting these receptors based on existing cryo-electron microscopy structures.The available structural insights into ligand-binding pockets and G protein-receptor interaction interfaces provide a clear perspective and valuable complement to ligand optimization.展开更多
Motivated by the recent discovery of superconductivity in the kagome metal CsCr_(3)Sb_(5) under pressure,we theoretically investigate the superconducting pairing symmetry and the impact of spin–orbit coupling(SOC)in ...Motivated by the recent discovery of superconductivity in the kagome metal CsCr_(3)Sb_(5) under pressure,we theoretically investigate the superconducting pairing symmetry and the impact of spin–orbit coupling(SOC)in this system.By employing an effective four-orbital tight-binding model and solving the linearized gap equation within the random phase approximation,we find that the large inter-orbital spin fluctuations enhanced by Hund’s coupling promote a superconducting gap function with E_(2g)symmetry.The inclusion of SOC further stabilizes this gap symmetry.Our analysis also reveals that the d_(x^(2)-y^(2))orbital plays the dominant role in forming the superconducting pairs.展开更多
Rice fields are one of the largest sources of methane(CH4),a potent greenhouse gas contributing significantly to global warming.Elucidating the underlying mechanisms and mitigating CH4 emissions from paddy fields is c...Rice fields are one of the largest sources of methane(CH4),a potent greenhouse gas contributing significantly to global warming.Elucidating the underlying mechanisms and mitigating CH4 emissions from paddy fields is crucial for combating climate change while ensuring sustainable food production.This review investigates the biological processes governing CH4 generation in rice fields,focusing on how soil microorganisms generate CH4 under waterlogged,anaerobic conditions.It also explores the mechanisms by which CH4 escapes into the atmosphere through plant-mediated transport,diffusion,and ebullition.Several factors influencing CH4 emissions are discussed,including soil composition,water management,exogenous organic matter application,rice variety selection,and local climate conditions.Strategies that can be implemented to reduce CH4 emissions are assessed,such as alternate wetting and drying,urea deep placement,biochar application,optimized fertilizer application,and breeding of rice varieties with low CH4 emissions.Novel solutions,such as the enhancement of methane-consuming bacteria in soils using microbial-based approaches,are also explored.The importance of integrating innovative technologies,improved farming practices,and interdisciplinary research is emphasized to develop practical and scalable strategies for reducing CH4 emissions.By addressing these challenges,we can advance towards the attainment of sustainable agriculture and global climate goals.This review aims to serve as a comprehensive resource for researchers,policymakers,and practitioners seeking to understand and mitigate CH4 emissions from rice cultivation.展开更多
We report a theoretical investigation into superconductivity within the MAXH_(6) quaternary hydride system using first-principles calculations,where M and A denote alkali and alkaline earth elements,respectively,and X...We report a theoretical investigation into superconductivity within the MAXH_(6) quaternary hydride system using first-principles calculations,where M and A denote alkali and alkaline earth elements,respectively,and X represents transition metal elements.Systematic analysis of electronic band structures,phonon dispersions,and electron-phonon coupling reveals that substitution of MA binary metal combinations and X metal atoms can create favorable conditions for superconductivity.Mapping of superconducting critical temperatures,combined with dynamical stability analysis through phonon calculations,identifies ten superconducting candidates at ambient pressure.Among these,LiNaAgH_(6) exhibits nearly-free-electron behavior reminiscent of monovalent electron superconductors.It demonstrates exceptional superconducting properties with electron–phonon coupling λ=2.707,which yields a superconducting transition temperature T_(c) of 206.4 K using the Allen–Dynes formula.Its structural analogs MgNaPdH_(6),LiMgPdH_(6),LiMgAgH_(6),LiMgAuH_(6) all exhibit superconducting transition temperatures above 110 K.These findings advance our fundamental understanding of superconductivity in quaternary hydrides and provide guidance for rational design of new high-temperature superconducting materials.展开更多
Annual haze in Northern Thailand has become increasingly severe,impacting health and the environment.How-ever,the sources of the haze remain poorly quantified due to limited observational data on aerosol molecular tra...Annual haze in Northern Thailand has become increasingly severe,impacting health and the environment.How-ever,the sources of the haze remain poorly quantified due to limited observational data on aerosol molecular tracers.This study comprehensively investigates chemical composition of PM_(2.5),including both inorganic and organic compounds throughout haze and post-haze periods in 2019 at a rural site of Northern Thailand.Average PM_(2.5) concentrations during haze and post-haze period were 87±36 and 21±11μg/m^(3),respectively.Organic matter was the dominant contributor in PM_(2.5) mass,followed by water soluble inorganic ions and mineral dust.Molecular markers,including levoglucosan,dehydroabietic acid,and 4-nitrocatechol,and ions(Cl^(-),and K^(+)),were used to characterize low haze(PM_(2.5)<100μg/m^(3))and episodic haze(PM_(2.5)>100μg/m^(3)).Low haze is associated with local aerosols from agricultural waste burning,while episodic haze is linked to aged aerosols from mixed agricultural waste,softwood,and hardwood burning.Source apportionment incorporating these molecular markers in receptor modelling(Positive matrix factorization),identified three distinct biomass burning sources:mixed,local,and aged biomass burnings,contributing 31,19 and 13%of PM_(2.5) during haze period.During post-haze period,contributions shifted,with local biomass burning(32%)comparable to secondary sulfate(34%)and mixed dust and traffic sources(26%).These findings demonstrate that both regional and local sources con-tribute to severe haze,highlighting the need for integrated policies for cross-border cooperation as well as stricter regulations to reduce biomass burning in Northern Thailand and Southeast Asia.展开更多
We report the development of the[Pt_(0.75)Ti_(0.25)/Co-Ni multilayer/Ta]_n superlattice with strong spin-orbit torque,large perpendicular magnetic anisotropy,and remarkably low switching current density.We demonstrate...We report the development of the[Pt_(0.75)Ti_(0.25)/Co-Ni multilayer/Ta]_n superlattice with strong spin-orbit torque,large perpendicular magnetic anisotropy,and remarkably low switching current density.We demonstrate that the efficiency of the spin-orbit torque increases nearly linearly with the repetition number n,which is in excellent agreement with the spin Hall effect of the Pt_(0.75)Ti_(0.25)being essentially the only source of the observed spin-orbit torque.The perpendicular magnetic anisotropy field is also substantially enhanced by more than a factor of 2 as n increases from 1 to6.The[Pt_(0.75)Ti_(0.25)/Co-Ni multilayers/Ta]_n superlattice additionally exhibits deterministic,low-current-density magnetization switching despite the very large total layer thicknesses.The unique combination of strong spin-orbit torque,robust perpendicular magnetic anisotropy,low-current-density switching,and excellent high thermal stability makes the[Pt_(0.75)Ti_(0.25)/Co-Ni multilayer/Ta]_n superlattice a highly compelling material candidate for ultrafast,energy-efficient,and long-data-retention spintronic technologies.展开更多
A novel vibration isolation system designed for superior performance in low-frequency environments is proposed in this work.The isolator is based on a unique hexagonal arrangement of linear springs,allowing for an adj...A novel vibration isolation system designed for superior performance in low-frequency environments is proposed in this work.The isolator is based on a unique hexagonal arrangement of linear springs,allowing for an adjustable geometric configuration via the initial inclination angle.Based on the principle of Lagrangian mechanics,the equation of motion governing the structural dynamics is rigorously derived.The system is modeled as a strongly nonlinear single-degree-of-freedom dynamical system,loaded with a normalized payload and subject to harmonic base excitation.To analyze the steady-state response,the harmonic balance method is employed,providing accurate predictions of the payload's vibration amplitude and displacement transmissibility as functions of both the base excitation amplitude and frequency.The analysis reveals a direct relationship between the isolator's geometric and stiffness parameters and its load-bearing capacity,leading to the identification of three distinct operational regimes.Depending on the unloaded initial inclination angle,the equivalent stiffness ratio,and the payload design configuration,the system can exhibit one of three vibration isolation modes:(i)the quasizero stiffness(QZS)isolation mode,(ii)the zero linear stiffness with controllable nonlinear stiffness,and(iii)the full-band perfect zero stiffness.The vibration isolation performance of the proposed structure is thoroughly discussed for all three oscillation modes in terms of frequency response curves,displacement transmissibility,and time-domain responses.The key novel finding is that this structure can operate as a full-band,high-performance vibration isolator when the initial inclination angle is designed to be a right angle,enabling full isolation of the maximum possible payload.Moreover,the analytical results and numerical simulations demonstrate that the isolator's displacement transmissibility T with the unit dB tends to-∞as the air-damping coefficient approaches zero,enabling ideal vibration isolation across the entire excitation frequency range.These analytical insights are validated through comprehensive numerical simulations,which show excellent agreement with the theoretical predictions.展开更多
Recurrence of solid tumors after surgical resection is a major barrier to tissue regeneration.As an emerging treatment strategy,photo-thermo-electric therapy ablates tumor cells via photothermal effects and generates ...Recurrence of solid tumors after surgical resection is a major barrier to tissue regeneration.As an emerging treatment strategy,photo-thermo-electric therapy ablates tumor cells via photothermal effects and generates reactive oxygen species(ROS)via thermoelectric effects to disrupt heat shock proteins,thereby suppressing their protective function in tumor cells.However,conventional materials suffer from low thermoelectric efficiency and weak tissue penetration ability.In this study,we fabricated iodine-doped bismuth sulfide(I-Bi_(2)S_(3))nanorods with bonding heterostructures to improve thermoelectric performance.The approach employed iodine doping to introduce additional electrons,thereby regulating the band structure of Bi_(2)S_(3)and exploiting the dual low-energy vibration effect of the heterostructures to reduce thermal conductivity.More importantly,controlling the type of heterostructure modulated the bandgap width,thereby expanding the light absorption range to the higher-penetration near-infrared(NIR)-Ⅱregion for deep tissue treatment.The I-Bi_(2)S_(3)nanorods were incorporated into poly-L-lactic acid(PLLA)scaffolds to confer antitumor functionality.According to the results,the bonding heterostructures enhanced the conductivity of Bi_(2)S_(3)and reduced its thermal conductivity,significantly enhancing thermoelectric efficacy.The heterostructures reduced the bandgap of Bi_(2)S_(3)from 1.23 to 0.88 eV,enabling optical absorption in the NIR-Ⅱregion.The ROS tests showed that the PLLA/I-Bi_(2)S_(3)scaffold exhibited good photothermal effects and ROS generation under 1064-nm laser irradiation.The antitumor efficacy of the PLLA/I-Bi_(2)S_(3)scaffold reached 84.6%against MG-63 cells,demonstrating its exceptional potential in cancer treatment.展开更多
The practical use of lithium metal anodes(LMAs)is impeded by uncontrolled dendrite growth,primarily caused by uneven Li-ion flux and significant volume changes during cycling.To overcome these challenges,we present bi...The practical use of lithium metal anodes(LMAs)is impeded by uncontrolled dendrite growth,primarily caused by uneven Li-ion flux and significant volume changes during cycling.To overcome these challenges,we present binder-free holey wrinkled-multilayered graphene(HWMG)scaffolds for highperformance LMAs with long cycle life.Holey graphene oxide(HGO)sheets were restacked into particle-like holey wrinkled-multilayered graphene oxide(HWMGO)in a high-concentration GO suspension,in which few-layer HGOs were quickly stabilized and wrinkled during the drying process,and upon reduction,they transformed into HWMG.HWMG exhibited excellent adhesion due to chemical interactions via edge-located functional groups.Its particle-like morphology,with numerous nanopores and high porosity,conferred outstanding mechanical flexibility and low tortuosity,enabling uniform Li-ion flux,buffering volume expansion,and suppressing dendrite growth.As a result,excellent long-term stability over 800 cycles and a voltage hysteresis of ca.7 mV over 6000 h were realized for the HWMG scaffolds,and a high areal capacity of 3.34 mAh cm^(-2) at 0.3 C after 350 cycles was demonstrated in a full-cell configuration.This work promotes the practical application of LMAs by offering a scalable scaffold design that suppresses dendrites and enhances cycle life.展开更多
Self-trapped excitons(STEs),known for their unique radiative properties,have been harnessed in diverse photonic devices;however,their comprehensive understanding and manipulation remain elusive.In this study,we presen...Self-trapped excitons(STEs),known for their unique radiative properties,have been harnessed in diverse photonic devices;however,their comprehensive understanding and manipulation remain elusive.In this study,we present novel experimental and theoretical evidence revealing the hybrid nature and optical tunability of STE state in Cs_(2)Ag_(0.4)Na_(0.6)InCl_(6).The detection of the Fano resonance in laser energy-dependent Raman and photoluminescence spectra indicates the emergence of an exciton-phonon hybrid state,arising from robust quantum interference between the discrete phonon and continuum exciton states.Moreover,we demonstrate continuous tuning of this hybrid state with the energy and intensity of the laser field.These findings lay the foundation for a comprehensive understanding of the nature of STE and their potential for state control.展开更多
文摘By 2025,research on Traditional Chinese Medicine(TCM)meridians has generated 12-15 macro-level theories and over 20 specific hypotheses,manifesting a highly fragmented research landscape.Objective:This paper proposes the“Holistic Hierarchical Predictive-Integration Hypothesis”(HHPIT)to construct a unified theoretical framework that integrates the rational components of existing meridian hypotheses.Methods:The HHPIT hypothesis systematically reviews current meridian theories,employs interdisciplinary methodologies,integrates artificial intelligence technology,and establishes a three-tier architecture encompassing structural,functional,and systemic layers.Results:HHPIT successfully integrates diverse meridian theories,proposes a computable algorithmic pipeline,and provides specific application protocols for chronic disease treatment,anti-aging,and enhancement of Zang-fu organ functions.Conclusion:HHPIT offers a novel,computable,and verifiable research paradigm for meridian studies,promoting the modernization and internationalization of TCM theory.
文摘Background: Plant-based diets are eating patterns focusing on high intake of plant-basedfoods while limiting the intake of animal-based foods. In recent decades, plant-based dietshave received increasing attention for their potential benefits for humans and theenvironment. However, a comprehensive overview of the development trends and researchhotspots of plant-based diets is still lacking. Therefore, this scientometric study aimed to fillthis critical research gap. Methods: English literature related to plant-based diets publishedfrom 2012 to 2023 in Science Citation Index Expanded (SCIE) of Web of Science CoreCollection was collected on August 16, 2023, using relevant key terms. R-bibliometrix,CiteSpace, and VOSviewer were used to analyze data and construct knowledge graphs.Results: Overall, 4135 publications (3127 articles and 1008 reviews) were included in thisstudy, showing an obvious upward trend in this field annually from 2012 to 2023, rangingfrom 70 to 921. The USA published the highest number of studies (n =1158) and was theleading research center in this field worldwide. Universities were the main researchinstitutions;particularly, Harvard T.H. Chan School of Public Health contributed to thelargest number of publications (n = 88) and had an active cooperation with otherinstitutions. Mcclements DJ contributed the most publications (n = 49) and ranked firstamong the scholars in plant-based diets. The most productive academic journal (n = 353)on plant-based diets was Nutrients, with an IF2022 of 5.9, while Foods and Frontiers in Nutritionwere the relatively active journals in this field in recent years. “Quality,” “milk,” “culturedmeat,” “plant protein,” “environmental impacts,” “functional properties,” “plant-based meatalternative,” “dietary change,” “vegan diet,” “plant-based beverage,” “gut microbiota,”“middle-income countries,” and “chronic kidney disease” were the main research hotspotsand frontiers in the field of plant-based diets. Conclusion: This study provides acomprehensive overview of global research on plant-based diets. Although research in thisfield has gained increasing attention in recent decades, cooperation among differentinstitutions and researchers should be significantly strengthened. Moreover, more studiesare needed to further assess the health and environmental impacts of plant-based diets.
基金financially supported by the National Key Research and Development Program of China(Grant No.2021YFA1400403)the National Natural Science Foundation of China(Grant Nos.12374183,92165205)+2 种基金the Natural Science Foundation of Jiangsu Province(Grant No.BK20233001)the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0302800)the Fundamental Research Funds for the Central Universities(Grant No.020414380207).
文摘Interplay between topology and magnetism can give rise to exotic properties in topological materials.Two-dimensional bismuth has been extensively studied owing to its topological states with a strong spin-orbit coupling,and 1T-VTe_(2)monolayer theoretically predicted to host an intrinsic magnetism as experimentally suggested.In this work,we successfully constructed a vertical heterostructure composed of the two-dimensional Bi(110)monolayer and 1T-VTe_(2)monolayer by using molecular beam epitaxy(MBE).Scanning tunneling microscopy(STM)measurements revealed that the growth of Bi preferably occurs along the step edges of the VTe_(2)monolayer,forming a Bi(110)monolayer on top of the VTe_(2)monolayer next to a peripheral Bi bilayer.The Bi(100)/VTe_(2)heterostructure exhibits a specific lattice registry with a well-defined moiréperiodicity.Scanning tunneling spectroscopy(STS)measurements further unveiled an universal suppression in the local density-of-states at the boundary of the Bi(110)/VTe_(2)bilayer.By examining the atomic structures of Bi(110)boundaries,we found this effect does not originate from the previously proposed atomic reconstruction at the step edge of Bi(110),but is likely related to the magnetic properties of the VTe_(2)monolayer.
基金support from the National Key Projects for Research and Development of China(Grant Nos.2022YFA1204700,2021YFA1400400)National Natural Science Foundation of China(Grant No.12525403)+3 种基金Natural Science Foundation of Jiangsu Province(Grant Nos.BK20220066,BK20233001)Program for Innovative Talents and Entrepreneur in Jiangsu(Grant No.JSSCTD202101)support from the JSPS KAKENHI(Grant Numbers 21H05233 and 23H02052)World Premier International Research Center Initiative(WPI),MEXT,Japan.
文摘Coulomb drag refers to the phenomenon in which a current driven through one conducting layer induces a voltage nearby,electrically isolated layer sorely through interlayer Coulomb interactions between charge carriers.It has been extensively studied in various systems,including parallel nanowires,double quantum wells,and double-layer graphene.Here,we report the observation of Coulomb drag in a novel system consisting of two graphene layers separated laterally by a 30 nm gap within the material plane,exhibiting behavior distinct from that in vertical graphene heterostructures.Our experiments reveal pronounced negative drag resistances under an out-of-plane magnetic field at the quantum Hall edges,reaching a maximum when the carrier densities in both graphene layers are tuned to the charge neutrality point via gate voltages.Our work establish two separate and spatially closed quantum Hall edge modes as a new platform to explore electronic interaction physics between one dimensional systems.
基金supported by the National Natural Science Foundation of China (Grant Nos.T2325004 and 52161160330)the National Natural Science Foundation of China (Grants No.12504233)+2 种基金Advanced MaterialsNational Science and Technology Major Project (Grant No.2024ZD0606900)the Talent Hub for “AI+New Materials” Basic Researchthe Key Research and Development Program of Ningbo (Grant No.2025Z088)。
文摘The functional properties of glasses are governed by their formation history and the complex relaxation processes they undergo.However,under extreme conditions,glass behaviors are still elusive.In this study,we employ simulations with varied protocols to evaluate the effectiveness of different descriptors in predicting mechanical properties across both low-and high-pressure regimes.Our findings demonstrate that conventional structural and configurational descriptors fail to correlate with the mechanical response following pressure release,whereas the activation energy descriptor exhibits robust linearity with shear modulus after correcting for pressure effects.Notably,the soft mode parameter emerges as an ideal and computationally efficient alternative for capturing this mechanical behavior.These findings provide critical insights into the influence of pressure on glassy properties,integrating the distinct features of compressed glasses into a unified theoretical framework.
基金supported by Kashan University of Medical Science,Kashan,Iran(Grant No.40001).
文摘Objective:To investigate the potential of oral probiotics to improve sperm motility and decrease DNA fragmentation in men diagnosed with asthenozoospermia.Methods:Men diagnosed with asthenozoospermia,aged between 18 and 40 years,were randomly assigned to receive probiotic or placebo for 10 weeks.Sperm parameters(count,motility,and morphology)and seminal fluid biochemical markers were assessed using light microscopy and Diff-Quik staining.Intracellular reactive oxygen species levels were measured using the malondialdehyde(MDA)technique,while DNA fragmentation index(DFI)was evaluated through acidic aniline blue staining.Data from both groups were compared to determine the effects of probiotic supplementation.Results:Sixteen men were included.The probiotic group(n=8)showed a significant increase in total sperm motility(P<0.001)and progressive motility(P=0.003)compared to the placebo group(n=8).Additionally,sperm count in the probiotic group was significantly higher than in the placebo group,although other sperm parameters did not show significant changes.Notably,levels of MDA(P=0.027)and DFI(P=0.004)were significantly reduced in the probiotic group,indicating a decrease in oxidative stress and DNA damage.Conclusions:Probiotic supplementation effectively enhances sperm quality by mitigating oxidative stress and reducing DNA damage,thereby improving sperm motility in men with asthenozoospermia.Study registration:The trial was registered with the Iranian Registry of Clinical Trials(IRCT20220119053769N1).
基金supported by the National Natural Science Foundation of China(Grant No.12302070)the Natural Science Foundation of Ningxia(Grant No.2024AAC05002)+1 种基金the Youth Science and Technology Talent Cultivation Project of Ningxiathe Ningxia Science and Technology Leading Talent Training Program(Grant No.2022GKLRLX04)。
文摘Neuromorphic circuits based on superconducting tunnel junctions have attracted much attention due to their highspeed computing capabilities and low energy consumption.Josephson junction circuits can effectively mimic biological neural dynamics.Leveraging these advantages,we construct a Josephson junction neuron-like model with a phasedependent dissipative current,referred to as a memristive current.The proposed memristive Josephson junction model exhibits complex dynamical behaviors.Furthermore,considering the effect of a fast-modulated synapse,we explore synchronization phenomena in coupled networks under varying coupling conductances and excitatory/inhibitory interactions.Finally,we extend the neuromorphic Josephson junction model—exhibiting complex dynamics—to the field of image encryption.These results not only enrich the understanding of the dynamical characteristics of memristive Josephson junctions but also provide a theoretical basis and technical support for the development of new neural networks and their applications in information security technology.
基金Supported by Science and Technology Development Plan Project of Jilin Province China(Grant No.20260102245JC)Supported by National Natural Science Foundation of China(Grant No.11771070).
文摘In this paper,we derive the sub-Riemannian version of the Kastler-Kalau-Walze type theorem and the Dabrowski-Sitarz-Zalecki type theorem for the twisted BCV spaces.We also compute the Connes conformal invariants for the twisted product,as well as the sub-Riemannian limits of the Connes conformal invariants for the twisted BCV spaces.
基金supported by the Korea Institute of Energy Technology Evaluation and Planning(KETEP)and the Ministry of Trade,Industry&Energy(MOTIE)of the Republic of Korea(No.RS-2025-02315209).
文摘There is a need for accurate prediction of heat and mass transfer in aerodynamically designed,non-Newtonian nanofluids across aerodynamically designed,high-flux biomedical micro-devices for thermal management and reactive coating processes,but existing work is not uncharacteristically remiss regarding viscoelasticity,radiative heating,viscous dissipation,and homogeneous–heterogeneous reactions within a single scheme that is calibrated.This research investigates the flow of Williamson nanofluid across a dynamically wedged surface under conditions that include viscous dissipation,thermal radiation,and homogeneous-heterogeneous reactions.The paper develops a detailed mathematical approach that utilizes boundary layers to transform partial differential equations into ordinary differential equations using similarity transformations.RK4 is the technique for gaining numerical solutions,but with the addition of ANNs,there is an improvement in prediction accuracy and computational efficiency.The study investigates the influence of wedge angle parameter,along with Weissenberg number,thermal radiation parameter and Brownian motion parameter,and Schmidt number,on velocity distribution,temperature distribution,and concentra-tion distribution.Enhanced Weissenberg numbers enhance viscoelastic responses that modify velocity patterns,but radiation parameters and thermophoresis have key impacts on thermal transfer phenomena.This research develops findings that are of enormous application in aerospace,biomedical(artificial hearts and drug delivery),and industrial cooling technology applications.New findings on non-Newtonian nanofluids under full flow systems are included in this work to enhance heat transfer methods in novel fluid-based systems.
基金supported by National Institutes of Health(NIH)Grants AG063944 and AG080047 to KAM.
文摘Advances in skeletal muscle omics has expanded our understanding of exercise-induced adaptations at the molecular level.Over the past 2 decades,transcriptome studies in muscle have detailed acute and chronic responses to resistance,endurance,and concurrent exercise,focusing on variables such as training status,nutrition,age,sex,and metabolic health profile.Multi-omics approaches,such as the integration of transcriptomic and epigenetic data,along with emerging ribosomal RNA sequencing advancements,have further provided insights into how skeletal muscle adapts to exercise across the lifespan.Downstream of the transcriptome,proteomic and phosphoproteomic studies have identified novel regulators of exercise adaptations,while single-cell/nucleus and spatial sequencing technologies promise to evolve our understanding of cellular specialization and communication in and around skeletal muscle cells.This narrative review highlights(a)the historical foundations of exercise omics in skeletal muscle,(b)current research at 3 layers of the omics cascade(DNA,RNA,and protein),and(c)applications of single-cell omics and spatial sequencing technologies to study skeletal muscle adaptation to exercise.Further elaboration of muscle's global molecular footprint using multi-omics methods will help researchers and practitioners develop more effective and targeted approaches to improve skeletal muscle health as well as athletic performance.
基金supported by the Shenzhen Science and Technology Innovation Commission,No.JCYJ20220818103009018(to YD).
文摘The arginine-phenylalanine-amide neuropeptide receptor family comprises a subclass within the G protein-coupled receptor superfamily with crucial roles in physiological regulation.These receptors recognize and bind neuropeptides with an arginine-phenylalanine-amide motif,thereby participating in a variety of biological processes such as energy metabolism,pain perception,and reproductive functions.In this review,we explore the physiological and pathological processes involving these receptors and delve into the structure-activity relationships of their ligand peptides,clarifying the key structural motifs within these neuropeptides that determine their biological activity,pharmacological potency,and receptor selectivity.Particular emphasis is placed on their roles in modulating nociception,regulating appetite,and maintaining reproductive health.Additionally,we discuss the therapeutic potential of structure-based drug design targeting these receptors based on existing cryo-electron microscopy structures.The available structural insights into ligand-binding pockets and G protein-receptor interaction interfaces provide a clear perspective and valuable complement to ligand optimization.
基金supported by the National Key Research and Development of China(Grant Nos.2024YFA1408104 and 2021YFA1400400)the National Natural Science Foundation of China(Grant Nos.12374137,12434005,12074175,92165205,12004191,and 12550405)the Natural Science Foundation of Jiangsu Province(Grant No.BK20233001)。
文摘Motivated by the recent discovery of superconductivity in the kagome metal CsCr_(3)Sb_(5) under pressure,we theoretically investigate the superconducting pairing symmetry and the impact of spin–orbit coupling(SOC)in this system.By employing an effective four-orbital tight-binding model and solving the linearized gap equation within the random phase approximation,we find that the large inter-orbital spin fluctuations enhanced by Hund’s coupling promote a superconducting gap function with E_(2g)symmetry.The inclusion of SOC further stabilizes this gap symmetry.Our analysis also reveals that the d_(x^(2)-y^(2))orbital plays the dominant role in forming the superconducting pairs.
基金supported by the Cooperative Research Program for Agriculture Science and Technology Development,Republic of Korea(Grant No.RS-2022-RD010034)the 2023 Yellow Sea Wetland International Cooperation Key Project,China(Grant No.HHSDKT202303).
文摘Rice fields are one of the largest sources of methane(CH4),a potent greenhouse gas contributing significantly to global warming.Elucidating the underlying mechanisms and mitigating CH4 emissions from paddy fields is crucial for combating climate change while ensuring sustainable food production.This review investigates the biological processes governing CH4 generation in rice fields,focusing on how soil microorganisms generate CH4 under waterlogged,anaerobic conditions.It also explores the mechanisms by which CH4 escapes into the atmosphere through plant-mediated transport,diffusion,and ebullition.Several factors influencing CH4 emissions are discussed,including soil composition,water management,exogenous organic matter application,rice variety selection,and local climate conditions.Strategies that can be implemented to reduce CH4 emissions are assessed,such as alternate wetting and drying,urea deep placement,biochar application,optimized fertilizer application,and breeding of rice varieties with low CH4 emissions.Novel solutions,such as the enhancement of methane-consuming bacteria in soils using microbial-based approaches,are also explored.The importance of integrating innovative technologies,improved farming practices,and interdisciplinary research is emphasized to develop practical and scalable strategies for reducing CH4 emissions.By addressing these challenges,we can advance towards the attainment of sustainable agriculture and global climate goals.This review aims to serve as a comprehensive resource for researchers,policymakers,and practitioners seeking to understand and mitigate CH4 emissions from rice cultivation.
基金supported by the National Key R&D Program of China (Grant No.2022YFA1403201)the National Natural Science Foundation of China (Grant Nos.12125404,T2495231,123B2049,and 12204138)+9 种基金the Advanced MaterialsNational Science and Technology Major Project (Grant No.2024ZD0607000)the Natural Science Foundation of Jiangsu Province (Grant Nos.BK20233001 and BK20253009)the Jiangsu Funding Program for Excellent Postdoctoral Talent (Grant No.2024ZB002)the China Postdoctoral Science Foundation (Grant No.2025M773331)the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of Chinathe AI&AI for Science program of Nanjing UniversityArtificial Intelligence and Quantum physics (AIQ) program of Nanjing Universitythe Fundamental Research Funds for the Central Universitiesthe Natural Science Foundation of Nanjing University of Posts and Telecommunications(Grant Nos.NY224165,NY220038,and NY219087)the Hua Li Talents Program of Nanjing University of Posts and Telecommunications。
文摘We report a theoretical investigation into superconductivity within the MAXH_(6) quaternary hydride system using first-principles calculations,where M and A denote alkali and alkaline earth elements,respectively,and X represents transition metal elements.Systematic analysis of electronic band structures,phonon dispersions,and electron-phonon coupling reveals that substitution of MA binary metal combinations and X metal atoms can create favorable conditions for superconductivity.Mapping of superconducting critical temperatures,combined with dynamical stability analysis through phonon calculations,identifies ten superconducting candidates at ambient pressure.Among these,LiNaAgH_(6) exhibits nearly-free-electron behavior reminiscent of monovalent electron superconductors.It demonstrates exceptional superconducting properties with electron–phonon coupling λ=2.707,which yields a superconducting transition temperature T_(c) of 206.4 K using the Allen–Dynes formula.Its structural analogs MgNaPdH_(6),LiMgPdH_(6),LiMgAgH_(6),LiMgAuH_(6) all exhibit superconducting transition temperatures above 110 K.These findings advance our fundamental understanding of superconductivity in quaternary hydrides and provide guidance for rational design of new high-temperature superconducting materials.
文摘Annual haze in Northern Thailand has become increasingly severe,impacting health and the environment.How-ever,the sources of the haze remain poorly quantified due to limited observational data on aerosol molecular tracers.This study comprehensively investigates chemical composition of PM_(2.5),including both inorganic and organic compounds throughout haze and post-haze periods in 2019 at a rural site of Northern Thailand.Average PM_(2.5) concentrations during haze and post-haze period were 87±36 and 21±11μg/m^(3),respectively.Organic matter was the dominant contributor in PM_(2.5) mass,followed by water soluble inorganic ions and mineral dust.Molecular markers,including levoglucosan,dehydroabietic acid,and 4-nitrocatechol,and ions(Cl^(-),and K^(+)),were used to characterize low haze(PM_(2.5)<100μg/m^(3))and episodic haze(PM_(2.5)>100μg/m^(3)).Low haze is associated with local aerosols from agricultural waste burning,while episodic haze is linked to aged aerosols from mixed agricultural waste,softwood,and hardwood burning.Source apportionment incorporating these molecular markers in receptor modelling(Positive matrix factorization),identified three distinct biomass burning sources:mixed,local,and aged biomass burnings,contributing 31,19 and 13%of PM_(2.5) during haze period.During post-haze period,contributions shifted,with local biomass burning(32%)comparable to secondary sulfate(34%)and mixed dust and traffic sources(26%).These findings demonstrate that both regional and local sources con-tribute to severe haze,highlighting the need for integrated policies for cross-border cooperation as well as stricter regulations to reduce biomass burning in Northern Thailand and Southeast Asia.
基金supported by the Beijing Natural Science Foundation(Grant No.Z230006)the National Key Research and Development Program of China(Grant No.2022YFA1204000)the National Natural Science Foundation of China(Grant Nos.12274405 and 12393831)。
文摘We report the development of the[Pt_(0.75)Ti_(0.25)/Co-Ni multilayer/Ta]_n superlattice with strong spin-orbit torque,large perpendicular magnetic anisotropy,and remarkably low switching current density.We demonstrate that the efficiency of the spin-orbit torque increases nearly linearly with the repetition number n,which is in excellent agreement with the spin Hall effect of the Pt_(0.75)Ti_(0.25)being essentially the only source of the observed spin-orbit torque.The perpendicular magnetic anisotropy field is also substantially enhanced by more than a factor of 2 as n increases from 1 to6.The[Pt_(0.75)Ti_(0.25)/Co-Ni multilayers/Ta]_n superlattice additionally exhibits deterministic,low-current-density magnetization switching despite the very large total layer thicknesses.The unique combination of strong spin-orbit torque,robust perpendicular magnetic anisotropy,low-current-density switching,and excellent high thermal stability makes the[Pt_(0.75)Ti_(0.25)/Co-Ni multilayer/Ta]_n superlattice a highly compelling material candidate for ultrafast,energy-efficient,and long-data-retention spintronic technologies.
基金Project supported by the National Key R&D Program of China(No.2023YFE0125900)。
文摘A novel vibration isolation system designed for superior performance in low-frequency environments is proposed in this work.The isolator is based on a unique hexagonal arrangement of linear springs,allowing for an adjustable geometric configuration via the initial inclination angle.Based on the principle of Lagrangian mechanics,the equation of motion governing the structural dynamics is rigorously derived.The system is modeled as a strongly nonlinear single-degree-of-freedom dynamical system,loaded with a normalized payload and subject to harmonic base excitation.To analyze the steady-state response,the harmonic balance method is employed,providing accurate predictions of the payload's vibration amplitude and displacement transmissibility as functions of both the base excitation amplitude and frequency.The analysis reveals a direct relationship between the isolator's geometric and stiffness parameters and its load-bearing capacity,leading to the identification of three distinct operational regimes.Depending on the unloaded initial inclination angle,the equivalent stiffness ratio,and the payload design configuration,the system can exhibit one of three vibration isolation modes:(i)the quasizero stiffness(QZS)isolation mode,(ii)the zero linear stiffness with controllable nonlinear stiffness,and(iii)the full-band perfect zero stiffness.The vibration isolation performance of the proposed structure is thoroughly discussed for all three oscillation modes in terms of frequency response curves,displacement transmissibility,and time-domain responses.The key novel finding is that this structure can operate as a full-band,high-performance vibration isolator when the initial inclination angle is designed to be a right angle,enabling full isolation of the maximum possible payload.Moreover,the analytical results and numerical simulations demonstrate that the isolator's displacement transmissibility T with the unit dB tends to-∞as the air-damping coefficient approaches zero,enabling ideal vibration isolation across the entire excitation frequency range.These analytical insights are validated through comprehensive numerical simulations,which show excellent agreement with the theoretical predictions.
基金National Key Research and Development Program of China(No.2023YFB4605800)The National Natural Science Foundation of China(Nos.52475362,52365046,and 52465041)+3 种基金Jiangxi Provincial Natural Science Foundation of China(No.20224ACB204013)Jiangxi Provincial Key Laboratory of Additive Manufacturing of Implantable Medical Device(No.2024SSY11161)Jiangxi Provincial Department of Education Science and Technology Project(No.GJJ2400708)Jiangxi Province Science and Technology Program(Nos.20252BAC200317 and 20252BEJ730195)。
文摘Recurrence of solid tumors after surgical resection is a major barrier to tissue regeneration.As an emerging treatment strategy,photo-thermo-electric therapy ablates tumor cells via photothermal effects and generates reactive oxygen species(ROS)via thermoelectric effects to disrupt heat shock proteins,thereby suppressing their protective function in tumor cells.However,conventional materials suffer from low thermoelectric efficiency and weak tissue penetration ability.In this study,we fabricated iodine-doped bismuth sulfide(I-Bi_(2)S_(3))nanorods with bonding heterostructures to improve thermoelectric performance.The approach employed iodine doping to introduce additional electrons,thereby regulating the band structure of Bi_(2)S_(3)and exploiting the dual low-energy vibration effect of the heterostructures to reduce thermal conductivity.More importantly,controlling the type of heterostructure modulated the bandgap width,thereby expanding the light absorption range to the higher-penetration near-infrared(NIR)-Ⅱregion for deep tissue treatment.The I-Bi_(2)S_(3)nanorods were incorporated into poly-L-lactic acid(PLLA)scaffolds to confer antitumor functionality.According to the results,the bonding heterostructures enhanced the conductivity of Bi_(2)S_(3)and reduced its thermal conductivity,significantly enhancing thermoelectric efficacy.The heterostructures reduced the bandgap of Bi_(2)S_(3)from 1.23 to 0.88 eV,enabling optical absorption in the NIR-Ⅱregion.The ROS tests showed that the PLLA/I-Bi_(2)S_(3)scaffold exhibited good photothermal effects and ROS generation under 1064-nm laser irradiation.The antitumor efficacy of the PLLA/I-Bi_(2)S_(3)scaffold reached 84.6%against MG-63 cells,demonstrating its exceptional potential in cancer treatment.
基金supported by the National Research Foundation of Korea(NRF)grants funded by the Korean government(MSIT)(RS-2024-00409952,RS-2024-00347936,and RS-202400407282)supported by the GRRC Program of Gyeonggi Province(GRRCHanyang2020-B01)supported by the Commercialization Promotion Agency for R&D Outcomes(COMPA)grant funded by the Korean Government(MSIT)(RS-2023-00304763)。
文摘The practical use of lithium metal anodes(LMAs)is impeded by uncontrolled dendrite growth,primarily caused by uneven Li-ion flux and significant volume changes during cycling.To overcome these challenges,we present binder-free holey wrinkled-multilayered graphene(HWMG)scaffolds for highperformance LMAs with long cycle life.Holey graphene oxide(HGO)sheets were restacked into particle-like holey wrinkled-multilayered graphene oxide(HWMGO)in a high-concentration GO suspension,in which few-layer HGOs were quickly stabilized and wrinkled during the drying process,and upon reduction,they transformed into HWMG.HWMG exhibited excellent adhesion due to chemical interactions via edge-located functional groups.Its particle-like morphology,with numerous nanopores and high porosity,conferred outstanding mechanical flexibility and low tortuosity,enabling uniform Li-ion flux,buffering volume expansion,and suppressing dendrite growth.As a result,excellent long-term stability over 800 cycles and a voltage hysteresis of ca.7 mV over 6000 h were realized for the HWMG scaffolds,and a high areal capacity of 3.34 mAh cm^(-2) at 0.3 C after 350 cycles was demonstrated in a full-cell configuration.This work promotes the practical application of LMAs by offering a scalable scaffold design that suppresses dendrites and enhances cycle life.
基金funding support from the National Natural Science Foundation of China(Grant No.12525405)funding support from the National Natural Science Foundation of China(Grant No.12393831)the CAS Project for Young Scientists in Basic Research(Grant No.YSBR-120)。
文摘Self-trapped excitons(STEs),known for their unique radiative properties,have been harnessed in diverse photonic devices;however,their comprehensive understanding and manipulation remain elusive.In this study,we present novel experimental and theoretical evidence revealing the hybrid nature and optical tunability of STE state in Cs_(2)Ag_(0.4)Na_(0.6)InCl_(6).The detection of the Fano resonance in laser energy-dependent Raman and photoluminescence spectra indicates the emergence of an exciton-phonon hybrid state,arising from robust quantum interference between the discrete phonon and continuum exciton states.Moreover,we demonstrate continuous tuning of this hybrid state with the energy and intensity of the laser field.These findings lay the foundation for a comprehensive understanding of the nature of STE and their potential for state control.
