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High-temporal-resolution ERT characterization for vegetation effects on soil hydrological response under wet-dry cycles
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作者 Wei Yan Weiming Xu +2 位作者 Taosheng Huang Ping Shen Wan-Huan Zhou 《Biogeotechnics》 2025年第2期13-20,共8页
Characterization of vegetation effect on soil response is essential for comprehending site-specific hydrological processes.Traditional research often relies on sensors or remote sensing data to examine the hydrologica... Characterization of vegetation effect on soil response is essential for comprehending site-specific hydrological processes.Traditional research often relies on sensors or remote sensing data to examine the hydrological properties of vegetation zones,yet these methods are limited by either measurement sparsity or spatial inaccuracy.Therefore,this paper is the first to propose a data-driven approach that incorporates high-temporal-resolution electrical resistivity tomography(ERT)to quantify soil hydrological response.Time-lapse ERT is deployed on a vegetated slope site in Foshan,China,during a discontinuous rainfall induced by Typhoon Haikui.A total of 97 ERT measurements were collected with an average time interval of 2.7 hours.The Gaussian Mixture Model(GMM)is applied to quantify the level of response and objectively classify impact zones based on features extracted directly from the ERT data.The resistivity-moisture content correlation is established based on on-site sensor data to characterize infiltration and evapotranspiration across wet-dry conditions.The findings are compared with the Normalized Difference Vegetation Index(NDVI),a common indicator for vegetation quantification,to reveal potential spatial errors in remote sensing data.In addition,this study provides discussions on the potential applications and future directions.This paper showcases significant spatio-temporal advantages over existing studies,providing a more detailed and accurate characterization of superficial soil hydrological response. 展开更多
关键词 VEGETATION High temporal resolution Electrical resistivity tomography Soil hydrological response Gaussian mixture model
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Geophysics-informed stratigraphic modeling using spatial sequential Bayesian updating algorithm
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作者 Wei Yan Shouyong Yi +3 位作者 Taosheng Huang Jie Zou Wan-Huan Zhou Ping Shen 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第7期4400-4412,共13页
Challenges in stratigraphic modeling arise from underground uncertainty.While borehole exploration is reliable,it remains sparse due to economic and site constraints.Electrical resistivity tomography(ERT)as a cost-eff... Challenges in stratigraphic modeling arise from underground uncertainty.While borehole exploration is reliable,it remains sparse due to economic and site constraints.Electrical resistivity tomography(ERT)as a cost-effective geophysical technique can acquire high-density data;however,uncertainty and nonuniqueness inherent in ERT impede its usage for stratigraphy identification.This paper integrates ERT and onsite observations for the first time to propose a novel method for characterizing stratigraphic profiles.The method consists of two steps:(1)ERT for prior knowledge:ERT data are processed by soft clustering using the Gaussian mixture model,followed by probability smoothing to quantify its depthdependent uncertainty;and(2)Observations for calibration:a spatial sequential Bayesian updating(SSBU)algorithm is developed to update the prior knowledge based on likelihoods derived from onsite observations,namely topsoil and boreholes.The effectiveness of the proposed method is validated through its application to a real slope site in Foshan,China.Comparative analysis with advanced borehole-driven methods highlights the superiority of incorporating ERT data in stratigraphic modeling,in terms of prediction accuracy at borehole locations and sensitivity to borehole data.Informed by ERT,reduced sensitivity to boreholes provides a fundamental solution to the longstanding challenge of sparse measurements.The paper further discusses the impact of ERT uncertainty on the proposed model using time-lapse measurements,the impact of model resolution,and applicability in engineering projects.This study,as a breakthrough in stratigraphic modeling,bridges gaps in combining geophysical and geotechnical data to address measurement sparsity and paves the way for more economical geotechnical exploration. 展开更多
关键词 Stratigraphic modeling Electrical resistivity tomography(ERT) Site characterization Spatial sequential Bayesian updating(SSBU)algorithm Sparse measurements
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Mechanism Explanation of Influence of Dry Density and Water Content on Bentonite Swelling Process
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作者 LI Xiaoyue ZHENG Xinjiang 《Journal of Shanghai Jiaotong university(Science)》 EI 2024年第5期930-939,共10页
The swelling process of bentonite is vital for judging the time required for completing the swelling,estimating the engineering safety,and organizing the construction plan.Many factors affect the swelling process,and ... The swelling process of bentonite is vital for judging the time required for completing the swelling,estimating the engineering safety,and organizing the construction plan.Many factors affect the swelling process,and the underlying mechanisms still require to be clearly explained.In this paper,the swelling process of commercial bentonite in different molar concentrations of salt solution was studied by the one-dimensional free swelling test and constant volume swelling pressure test.The curves of swelling over time were fitted using a hyperbolic model,and two parameters were extracted to reflect the swelling rate and the final swelling strain or swelling pressure quantitatively,respectively.The test results show that the final swelling strain or swelling pressure is determined by the swelling ability of the bentonite,while the swelling rate is influenced by the coupled effect of the swelling ability and permeability of soil.The mechanisms of different factors affecting the swelling process of bentonite are summarized as the effects on the permeability and swelling ability of the soil by considering the change process of pore structure during swelling.The proposed mechanism explanation can also reasonably explain the effect of initial water content in the existing literature.The influencing mechanism of the swelling process revealed in this paper from the perspective of pore structure provides a reasonable theoretical basis for analyzing the swelling process of bentonite. 展开更多
关键词 swelling process free swelling constant volume swelling swelling strain swelling pressure
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Natural hydrogel dressings in wound care: Design, advances, and perspectives
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作者 Xiaoliu Liang Chunliu Huang +4 位作者 Hui Liu Hu Chen Jiabao Shou Hongwei Cheng Gang Liu 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第10期28-38,共11页
Natural hydrogels have emerged as a pivotal innovation in wound care,offering a unique combination of high absorbency,biocompatibility,and versatility.However,due to the complexity of wound healing,the physiological s... Natural hydrogels have emerged as a pivotal innovation in wound care,offering a unique combination of high absorbency,biocompatibility,and versatility.However,due to the complexity of wound healing,the physiological state of the wound varies dynamically,and the mechanism of natural hydrogels that boost wound healing is still unclear.In this review,we firstly provide a comprehensive introduction to the bio-logical process of wound healing,emphasizing the critical stages and factors affecting healing.This work concludes the composition and properties of natural hydrogels,including collagen,gelatin,hyaluronic acid,chitosan,alginates,cellulose,and fibroin,highlighting their biocompatibility and biodegradability.The focus shifts to the various crosslinking strategies employed to enhance the structural integrity and functionality of natural hydrogels.This review further investigates the biological effects of natural hydro-gels in wound healing,detailing their antibacterial,antioxidant,anti-inflammatory,adhesive,and hemo-static functions.Furthermore,we propose the challenges and future perspectives of natural hydrogels in practical applications.This review offers a comprehensive overview of the current state and poten-tial future advancements in natural hydrogel dressings for wound care,highlighting their critical role in addressing complex and hard-to-heal wounds. 展开更多
关键词 Natural hydrogel Wound dressing Crosslinking strategy ANTIBACTERIAL ANTI-INFLAMMATION
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Remaining useful life prediction based on the Wiener process for an aviation axial piston pump 被引量:32
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作者 WangXingjian LinSiru +2 位作者 Wang Shaoping HeZhaomin ZhangChao 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2016年第3期779-788,共10页
An aviation hydraulic axial piston pump's degradation fiom comprehensive wear is a typical gradual failure model. Accurate wear prediction is difficult as random and uncertain char- acteristics must be factored into ... An aviation hydraulic axial piston pump's degradation fiom comprehensive wear is a typical gradual failure model. Accurate wear prediction is difficult as random and uncertain char- acteristics must be factored into the estimation. The internal wear status of the axial piston pump is characterized by the return oil flow based on fault mechanism analysis of the main frictional pairs in the pump. The performance degradation model is described by the Wiener process to predict the remaining useful life (RUL) of the pump. Maximum likelihood estimation (MLE) is performed by utilizing the expectation maximization (EM) algorithm to estimate the initial parameters of the Wiener process while recursive estimation is conducted utilizing the Kalman filter method to estimate the drift coefficient of the Wiener process. The RUL of the pump is then calculated accord- ing to the performance degradation model based on the Wiener process. Experimental results indi- cate that the return oil flow is a suitable characteristic for reflecting the internal wear status of the axial piston pump, and thus the Wiener process-based method may effectively predicate the RUL of the pump. 展开更多
关键词 Axial piston pump Hydraulic system Remaining useful lifeReturn oil flow WEAR Wiener process
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Exploration and implementation of commonality valuation method in commercial aircraft family design 被引量:3
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作者 Yongjie ZHANG Zheng YANG +4 位作者 Xianchao MA Wenjun DONG Dayong DONG Zhaoguang TAN Shuai ZHANG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2019年第8期1828-1846,共19页
Commercial aircraft family design can reduce development costs, shorten development cycles, and expand the market coverage of aircraft. Commercial aircraft family development has become one of the most important featu... Commercial aircraft family design can reduce development costs, shorten development cycles, and expand the market coverage of aircraft. Commercial aircraft family development has become one of the most important features of modern aircraft design. This paper explores the effects of commonality on different aircraft models in a commercial aircraft family. The existing product commonality indexes are summarized and their limitations in the application to aircraft design are discussed. Then a new component commonality index is proposed based on the component decomposition structure. A model for calculating the aircraft program value is established,which considers development costs, manufacturing costs, sale price, operation costs and residual costs. The effects of aircraft commonality on time and economic costs of both development and manufacturing, and on sale price, are analyzed and quantified. The commonality evaluation strategy is obtained, which features comprehensive consideration of the aircraft program value and time costs. The break-even analysis of aircraft is proceeded on the basis of costs and price data. By using a real option method, the strategy considers the uncertainty of the aircraft program and the flexibility of the manufacturer. This strategy proves to be rational and applicable to aircraft design based on the calculation of three examples and the analysis of parameter sensitivity. 展开更多
关键词 AIRCRAFT COST AIRCRAFT FAMILY AIRCRAFT program value COMMONALITY index REAL OPTION method
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2-Amino-4-(4-aminophenyl)thiazole application as an ionophore in the construction of a Lu(Ⅲ) selective membrane sensor 被引量:1
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作者 Mohammad Reza Pourjavid Taherehsadat Razavi 《Chinese Chemical Letters》 SCIE CAS CSCD 2012年第3期343-346,共4页
A derivative of thiazole(AAT) has been explored as a sensing material for preparation a selective Lu(III) PVC-based membrane sensor.The proposed sensor exhibits a Nernstian response over a wide concentration range... A derivative of thiazole(AAT) has been explored as a sensing material for preparation a selective Lu(III) PVC-based membrane sensor.The proposed sensor exhibits a Nernstian response over a wide concentration range from 1.0×10^(-6) to 1.0×10^(-1) mol/L of Lu(Ⅲ) and the detection limit is 5.7×10^(-7) mol/L.The sensor response is independent of pH of the solution in the range 3.2-8.8 and possesses the advantages of fast response time(~6) and in particular,good selectivity to the lutetium ions with regard to most common metal ions,and especially all lanthanide ions. 展开更多
关键词 Membrane sensor Lu(Ⅲ) selective Thiazole derivative PVC POTENTIOMETRY
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Mathematical approach for understanding deagglomeration behaviour of drug powder in formulations with coarse carrier
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作者 Irene Parisini James L.Collett Darragh Murnane 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2015年第6期501-512,共12页
Deagglomeration of cohesive particles in combination with coarse carrier is a key requirement for inhaled formulations.The aim of the project was to propose a mathematical approach to understand aerosolization behavio... Deagglomeration of cohesive particles in combination with coarse carrier is a key requirement for inhaled formulations.The aim of the project was to propose a mathematical approach to understand aerosolization behaviour of micronized particles alone and in formulation with carriers.Salbutamol sulphate and salmeterol xinafoate were blended separately with fine lactose(ratio 1:4)and fine and coarse lactose(1:4:63.5).Laser diffraction was employed to characterize the powder median particle size.The deagglomeration of micronized materials followed an asymptotic monoexponential relationship.When the coarse lactose was added,the relationship fitted a bi-exponential equation showing an easily and a poorly dispersed fraction.Using model hydrophobic and hydrophilic APIs,this study has demonstrated the utility of an analytical approach that can parameterize deagglomeration behaviour of carrier-free and carrier-based inhalation formulations.The analytical approach provides the ability to systematically study the effect of material,formulation and processing factors on deagglomeration behaviour. 展开更多
关键词 Ternary agents DEAGGLOMERATION Cohesive powders Non-linear regression modelling
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Tailoring WB morphology enables d-band centers to be highly active for high-performance lithium-sulfur battery
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作者 Yuwei Zhao Chang Liu +7 位作者 Chenyang Zha Jing Li Chongguang Lyu Kaixi Wang Junfeng Li Kwan San Hui Linghai Zhang Kwun Nam Hui 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第11期302-306,共5页
The d-band centers of catalysts have exhibited excellent performance in various reactions.Among them,the enhanced catalytic reaction is considered a crucial way to power dynamics and reduce the“shuttle”effect in pol... The d-band centers of catalysts have exhibited excellent performance in various reactions.Among them,the enhanced catalytic reaction is considered a crucial way to power dynamics and reduce the“shuttle”effect in polysulfide conversions of lithium-sulfur batteries.Here,we report two-dimensional-shaped tungsten borides(WB)nanosheets with d-band centers,where the d orbits of W atoms on the(001)facets show greatly promoting the electrocatalytic sulfur reduction reaction.As-prepared WB-based Li-S cells exhibit excellent electrochemical performance for Li-ion storage.Especially,it delivers superior capacities of 7.7 mAh/cm^(2) under the 8.0 mg/cm^(2) sulfur loading,which is far superior to most other electrode catalysts.This study provides insights into the d-band centers as a promising catalyst of twodimensional boride materials. 展开更多
关键词 d-band centers Tungsten borides ELECTROCATALYSIS NANOSHEET Lithium-sulfur battery
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The Relationship Between Job Burnout and Psychological Contract of Employee from the Perspective of Organizational Psychology
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作者 Wenya Ma 《Journal of Psychological Research》 2021年第1期16-21,共6页
In a fast-paced career,employees are facing more and more pressure,and job burnout caused by long-term work pressure has become the main reason for many employees to leave.If the job burnout can’t be effectively reso... In a fast-paced career,employees are facing more and more pressure,and job burnout caused by long-term work pressure has become the main reason for many employees to leave.If the job burnout can’t be effectively resolved,it will have a great impact on personal future development and the good running of the enterprise.Starting from the perspective of organizational psychology,this study investigates 200 employees on their psychological contracts and job burnouts to discover the relationship between them that people are most concerned about at the moment,so as to propose some reasonable suggestions to improve the employee job burnout and enhance the mutual identification between employee and the company.The research results show that job burnout and psychological contract show a critically negative correlation;the stronger the psychological contract,the lower the probability of employee job burnout.In addition,the establishment of a strong psychological contract between the company and the employee can effectively reduce the employee’s job burnout,thereby ensuring the mutual benefit of the employee and the company. 展开更多
关键词 Organizational psychology Job burnout Psychological contract
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Traffic flow prediction for highways based on a multi-task spatiotemporal graph network
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作者 Jinyong Gao Sheng Luo +2 位作者 Junshan Tian Cheng Zhou Lianhua An 《Transportation Safety and Environment》 2025年第1期114-121,共8页
Efficient and precise traffic flow prediction is highly important in effective traffic management.This research presents a novel prediction model that integrates highway spatial changes and flow-related information(sp... Efficient and precise traffic flow prediction is highly important in effective traffic management.This research presents a novel prediction model that integrates highway spatial changes and flow-related information(speed and vehicle composition).The highway is divided into segments,using key reference points like tunnels,toll stations and ramps.An adaptive graph convolutional network is employed to capture relationships between these segments.The network automatically adjusts adjacency matrix weights,facilitating the extraction of spatial flow features.Incorporating flow-related information,a multi-task module attention fusion network is introduced.The main task is traffic flow prediction,with average travel speed and vehicle composition as auxiliary tasks.This approach enhances feature acquisition and improves prediction accuracy.In experiments using Fuzhou–Jingtan Expressway data,the model significantly enhances prediction accuracy by at least 55%.Ablation experiments validate the effectiveness of the designed modules,improving the model’s accuracy from 20%to 45%. 展开更多
关键词 traffic flow prediction convolutional neural networks(CNNs) spatiotemporal graph attention mechanism
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Active-learning-driven error control for data-driven state of charge estimation across the lithium battery lifecycle
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作者 Jinwei Xue Xuzhi Du +7 位作者 Lei Zhao Zhigang Yang Chao Xia Yuan Ma Muhammad Jahidul Hoque Wuchen Fu Xiao Yan Nenad Miljkovic 《Energy and AI》 2025年第3期386-400,共15页
Accurate estimation of lithium-ion battery state of charge(SOC)is crucial for the safe and efficient operation of electric vehicles(EVs).However,both data-driven and model-driven SOC estimation methods face significan... Accurate estimation of lithium-ion battery state of charge(SOC)is crucial for the safe and efficient operation of electric vehicles(EVs).However,both data-driven and model-driven SOC estimation methods face significant challenges under battery aging,which alters internal resistance and electrochemical properties,especially across complex aging trajectories.Most existing deep learning and model-based approaches operate in an open-loop manner,lacking mechanisms for uncertainty quantification,accuracy prediction,or adaptive correction—leading to uncontrolled estimation errors during aging.To address this,we propose an innovative closed-loop SOC estimation framework that integrates active learning with uncertainty-aware correction into deep learning networks,enabling real-time feedback on SOC prediction confidence levels without the need for additional sensors or reference data.Specifically,we quantify the performance degradation of mainstream data-driven methods,including long short-term memory(LSTM)networks and Gaussian process regression(GPR),under complex aging paths.We demonstrate that our model-disagreement-based active learning correction strategy maintains robustness throughout the battery lifecycle.Experimental results show that with only four active retraining sessions over the full aging process,our method reduces average SOC estimation error to below 1.5%,and maximum cycle-based average error to below 2%.This work establishes a path toward uncertaintyinformed,lifecycle-resilient,and data-efficient SOC estimation,marking a significant advancement in battery management systems for real-world EV applications. 展开更多
关键词 Lithium-ion battery State of charge(SOC) Battery aging data-driven SOC estimation Deep learning Active learning Closed-loop correction
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A preclinical and first-in-human study of superstable homogeneous radiolipiodol for revolutionizing interventional diagnosis and treatment of hepatocellular carcinoma
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作者 Hu Chen Yongfu Xiong +15 位作者 Minglei Teng Yesen Li Deliang Zhang Yongjun Ren Zheng Li Hui Liu Xiaofei Wen Zhenjie Li Yang Zhang Syed Faheem Askari Rizvi Rongqiang Zhuang Jinxiong Huang Suping Li Jingsong Mao Hongwei Cheng Gang Liu 《Acta Pharmaceutica Sinica B》 2025年第10期5022-5035,共14页
Transarterial radioembolization(TARE)is a widely utilized therapeutic approach for hepatocellular carcinoma(HCC),however,the clinical implementation is constrained by the stringent preparation conditions of radioembol... Transarterial radioembolization(TARE)is a widely utilized therapeutic approach for hepatocellular carcinoma(HCC),however,the clinical implementation is constrained by the stringent preparation conditions of radioembolization agents.Herein,we incorporated the superstable homogeneous iodinated formulation technology(SHIFT),simultaneously utilizing an enhanced solvent form in a carbon dioxide supercritical fluid environment,to encapsulate radionuclides(such as^(131)I,^(177)Lu,or^(18)F)with lipiodol for the preparation of radiolipiodol.The resulting radiolipiodol exhibited exceptional stability and ultra-high labeling efficiency(≥99%)and displayed notable intratumoral radionuclide retention and in vivo stability more than 2 weeks following locoregional injection in subcutaneous tumors in mice and orthotopic liver tumors in rats and rabbits.Given these encouraging findings,^(18)F was authorized as a radiotracer in radiolipiodol for clinical trials in HCC patients,and showed a favorable tumor accumulation,with a tumor-to-liver uptake ratio of≥50 and minimal radionuclide leakage,confirming the feasibility of SHIFT for TARE applications.In the context of transforming from preclinical to clinical screening,the preparation of radiolipiodol by SHIFT represents an innovative physical strategy for radionuclide encapsulation.Hence,this work offers a reliable and efficient approach for TARE in HCC,showing considerable promise for clinical application(ChiCTR2400087731). 展开更多
关键词 Hepatocellular carcinoma Intravascular intervention Radionuclide LIPIODOL Superstable homogeneous iodinated formulation technology Nuclear medicine imaging Transarterial radioembolization THERANOSTICS
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Model and experiment-based evaluation of seawater-based urine phosphorus recovery(SUPR)process
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作者 Wen-Tao Tang Yihang Xiao +3 位作者 Yang-Fan Deng Yunkai TAN Guang-Hao Chen Tianwei HAO 《Frontiers of Environmental Science & Engineering》 SCIE EI CSCD 2024年第11期133-144,共12页
Leveraging seawater toilet flushing system in Hong Kong,China,a Seawater-based Urine Phosphorus Recovery(SUPR)process that integrates ureolysis and phosphorus(P)recovery was proposed in our earlier work.In this study,... Leveraging seawater toilet flushing system in Hong Kong,China,a Seawater-based Urine Phosphorus Recovery(SUPR)process that integrates ureolysis and phosphorus(P)recovery was proposed in our earlier work.In this study,a thermodynamic model was applied to evaluate the effects of ureolysis and the seawater-to-urine mixing ratio(S/U ratio)on P precipitation in the SUPR system.The results suggested that effective P recovery was thermodynamically feasible across a wide range of S/U ratios,with elevated pH levels resulting from ureolysis being critical for P precipitation.Furthermore,a SUPR reactor was developed to validate this process.When the hydraulic retention time(HRT)exceeded 3 h and the S/U ratio was lower than 3:1,more than 98%of P could be recovered without urine storage,chemical dosage,or external mixing.Further decrease in the HRT and increase in S/U ratio caused flushing out of fine precipitates,resulting in a relatively low P recovery efficiency.However,this could be advantageous when downstream urine nitrification is implemented,as dilution of urine can alleviate the inhibitory effects of free ammonia and free nitrous acid,as well as overcome the P limitation problem,thus facilitating urine nitrification.Consequently,there is a trade-off between optimizing P recovery and nitrification efficiencies. 展开更多
关键词 Phosphorus recovery STRUVITE Urine nitrification Source separation Seawater toilet flushing
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Revealing the secret behind Epstein-Barr virus-specific tumor immune contexture
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作者 Chu-Xia Deng 《Cancer Communications》 SCIE 2024年第4期491-494,共4页
Immune checkpoint inhibitor(ICI)therapy has sig-nificantly revolutionized cancer treatment across vari-ous malignancies,offering distinct and enduring clin-ical advantages[1].Gastric cancer(GC)represents a widespread ... Immune checkpoint inhibitor(ICI)therapy has sig-nificantly revolutionized cancer treatment across vari-ous malignancies,offering distinct and enduring clin-ical advantages[1].Gastric cancer(GC)represents a widespread and life-threatening malignancy with substan-tial global health implications[2].However,ICI therapy has not produced satisfactory therapeutic responses in GC patients. 展开更多
关键词 GASTRIC cancer IMMUNE
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Rhein-based Pickering emulsion for hepatocellular carcinoma:Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization
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作者 Xiaoliu Liang Hui Liu +10 位作者 Hu Chen Xuqi Peng Zhenjie Li Minglei Teng Yisheng Peng Jiwei Li Linyu Ding Jingsong Mao Chengchao Chu Hongwei Cheng Gang Liu 《Aggregate》 EI CAS 2024年第4期319-338,共20页
The efficacy of transarterial chemoembolization(TACE)has been limited by insufficient embolization and a high incidence of tumor recurrence.Herein,we iden-tified that aberrant metabolic reprogramming and immunosuppres... The efficacy of transarterial chemoembolization(TACE)has been limited by insufficient embolization and a high incidence of tumor recurrence.Herein,we iden-tified that aberrant metabolic reprogramming and immunosuppression contribute to TACE refractoriness and Rhein,as a potential glycolytic metabolism inhibitor and immunoactivation inducer,was optimized to sensitize tumors to TACE therapy.To achieve efficient embolization,we developed an oil-in-water lipiodol embolic emulsion by stabilizing the self-assembled Rhein nanogel.The assembled Rhein exhibited a nanofiber network,and its integration enhanced the mechanical stability and viscoelasticity of the lipiodol embolic agent.With the synergistic advantages of solid and liquid embolic agents,this carrier-free Pickering emulsion exhibits effi-cient embolization and sustained drug release in models of unilateral renal artery embolization,rabbit ear tumor embolization,rabbit orthotopic liver cancer,and rat orthotopic liver cancer.Compared to conventional three-way catheter mixing meth-ods,multimodal imaging corroborates a marked enhancement in local drug retention and tumor suppression.Importantly,the incorporation of Rhein-mediated syner-gistic immunoembolization in this strategy achieved efficient embolization while robustly activating anti-tumor immune responses,including inducing immunogenic cell death,dendritic cell activation,and major histocompatibility complex class I pre-sentation to CD8^(+)T cells for tumor killing.Together,thesefindings reveal a novel strategy for the application of self-assembled Rhein nanofiber-stabilized lipiodol emulsion to control metabolic signaling and immunoactivation in TACE. 展开更多
关键词 GLYCOLYSIS hepatocellular carcinoma immunoembolization Pickering emulsion transarterial chemoem-bolization
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Tunnel bottleneck management with high-occupancy vehicle priority on intelligent freeways
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作者 Jinyong Gao Juncheng Zeng +3 位作者 Xinyuan Wang Cheng Zhou Hailin Zhang Jintao Lai 《Transportation Safety and Environment》 EI 2024年第2期87-95,共9页
Tunnels on freeways,as one of the critical bottlenecks,frequently cause severe congestion and passenger delay.To solve the tunnel bottleneck problem,most of the existing research can be divided into two types.One is t... Tunnels on freeways,as one of the critical bottlenecks,frequently cause severe congestion and passenger delay.To solve the tunnel bottleneck problem,most of the existing research can be divided into two types.One is to adopt variable speed limits(VSLs)to regulate a predetermined speed for vehicles to get through a bottleneck smoothly.The other is to adopt high-occupancy vehicle(HOV)lane management.In HOV lane management strategies,all traffic is divided into HOVs and low-occupancy vehicles(LOVs).HOVs are vehicles with a driver and one or more passengers.LOVs are vehicles with only a driver.This kind of research can grant priority to HOVs by providing a dedicated HOV lane.However,the existing research cannot both mitigate congestion and maximize passenger-oriented benefits.To address the research gap,this paper leverages connected and automated vehicle(CAV)technologies on intelligent freeways and develops a tunnel bottleneck management strategy with a dynamic HOV lane(DHL).The strategy bears the following features:1)enables tunnel bottleneck management at a microscopic level;2)maximizes passenger-oriented benefits;3)grants priority to HOVs even when the HOV lane is open to LOVs;4)allocates right-of-way segments for HOVs and LOVs in real time;and 5)performs well in a mixed-traffic environment.The proposed strategy is evaluated through comparison against the non-control baseline and a VSL strategy.Sensitivity analysis is conducted under different congestion levels and penetration rates.The results demonstrate that the proposed strategy outperforms in terms of passenger-oriented delay reduction and HOVs’priority level improvement. 展开更多
关键词 tunnel bottleneck high-occupancy vehicle(HOV) intelligent freeways right-of-way segment
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An SAV Method for Imaginary Time Gradient Flow Model in Density Functional Theory 被引量:1
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作者 Ting Wang Jie Zhou Guanghui Hu 《Advances in Applied Mathematics and Mechanics》 SCIE 2023年第3期719-736,共18页
In this paper,based on the imaginary time gradient flow model in the density functional theory,a scalar auxiliary variable(SAV)method is developed for the ground state calculation of a given electronic structure syste... In this paper,based on the imaginary time gradient flow model in the density functional theory,a scalar auxiliary variable(SAV)method is developed for the ground state calculation of a given electronic structure system.To handle the orthonormality constraint on those wave functions,two kinds of penalty terms are introduced in designing the modified energy functional in SAV,i.e.,one for the norm preserving of each wave function,another for the orthogonality between each pair of different wave functions.A numerical method consisting of a designed scheme and a linear finite element method is used for the discretization.Theoretically,the desired unconditional decay of modified energy can be obtained from our method,while computationally,both the original energy and modified energy decay behaviors can be observed successfully from a number of numerical experiments.More importantly,numerical results show that the orthonormality among those wave functions can be automatically preserved,without explicitly preserving orthogonalization operations.This implies the potential of our method in large-scale simulations in density functional theory. 展开更多
关键词 Density functional theory gradient flow scalar auxiliary variable unconditional energy stability orthonormalization free
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An h-Adaptive Finite Element Solution of the Relaxation Non-Equilibrium Model for Gravity-Driven Fingers 被引量:1
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作者 Huanying Bian Yedan Shen Guanghui Hu 《Advances in Applied Mathematics and Mechanics》 SCIE 2021年第6期1418-1440,共23页
The study on the fingering phenomenon has been playing an important role in understanding the mechanism of the fluid flow through the porous media.In this paper,a numerical method consisting of the Crank-Nicolson sche... The study on the fingering phenomenon has been playing an important role in understanding the mechanism of the fluid flow through the porous media.In this paper,a numerical method consisting of the Crank-Nicolson scheme for the temporal discretization and the finite element method for the spatial discretization is proposed for the relaxation non-equilibrium Richards equation in simulating the fingering phenomenon.Towards the efficiency and accuracy of the numerical simulations,a predictor-corrector process is used for resolving the nonlinearity of the equation,and an h-adaptive mesh method is introduced for accurately resolving the solution around the wetting front region,in which a heuristic a posteriori error indicator is designed for the purpose.In numerical simulations,a traveling wave solution of the governing equation is derived for checking the numerical convergence of the proposed method.The effectiveness of the h-adaptive method is also successfully demonstrated by numerical experiments.Finally the mechanism on generating fingers is discussed by numerically studying several examples. 展开更多
关键词 Non-equilibrium Richard equation h-adaptive mesh method a posteriori error estimation fingering phenomenon porous media flow
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Unadjusted Langevin algorithms for SDEs with Hölder drift
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作者 Xiang Li Fengyu Wang Lihu Xu 《Science China Mathematics》 2025年第12期3017-3042,共26页
In this paper,we consider the following stochastic differential equation for(X_(t))_(t)≥0 on R^(d)and its Euler-Maruyama(EM)approximation(Y_(tn)_(n)∈Z^(+)):dX_(t)=b(X_(t))dt+σ(X_(t))dB_(t),Y_(t)_(n+1)=Y_)(t)_(n_(+1... In this paper,we consider the following stochastic differential equation for(X_(t))_(t)≥0 on R^(d)and its Euler-Maruyama(EM)approximation(Y_(tn)_(n)∈Z^(+)):dX_(t)=b(X_(t))dt+σ(X_(t))dB_(t),Y_(t)_(n+1)=Y_)(t)_(n_(+1ηn+1b(Y_(t)_(n)+σ(Y_(t)_(n)(B_(t)_(n)+1-B_(t)_(n),where b:R^(d)↦R^(d),σ:R^(d)→R^(d)×d are measurable,Bt is the d-dimensional Brownian motion,t_(0):=0,and t_(n):=∑_(k=1)^(n)η_(k)for constantsη_(k)>0 satisfying lim_(k)→∞η_(k)=0 and∑_(k=1)^(∞)ηk=∞.We investigate the convergence rates of Y_(t_(n))under both additive and multiplicative noise settings for different smoothness levels of b.When the noise is additive and partial dissipation conditions hold,we obtain explicit convergence rates of W_(p)(L(Y_(t_(n))),L(X_(t_(n))))+W_(p)(L(Y_(t_(n)))),μ)→0 as n→∞,where W_(p) is the Lp-Wasserstein distance for p∈[0,1],L(ξ)denotes the distribution ofξ,andμis the unique invariant probability measure of(X_(t))_(t)≥0.When the noise is multiplicative and global dissipation conditions hold,the convergence rate of Wp(L(Y_(t_(n))),L(X_(t_(n))))for p≥2 is studied.Compared with the existing results where b is usually C^(1) or C^(2) smooth,our estimates apply to Hölder continuous drift and clearly demonstrate the dependence of the convergence rate on the smoothness of b. 展开更多
关键词 unadjusted Langevin algorithm singular drift SDEs Euler-Maruyama scheme with decreasing step Wasserstein distance total variation distance convergence rate
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