Objectives:Non-suicidal self-injury(NSSI)represents a prominent and escalating concern within mental health,associated with considerable psychological and physical dangers.Peer victimization is identified as a signifi...Objectives:Non-suicidal self-injury(NSSI)represents a prominent and escalating concern within mental health,associated with considerable psychological and physical dangers.Peer victimization is identified as a significant predictor of NSSI behavior.Although prior research has explored the association between peer victimization and NSSI,the mechanisms underlying this relationship remain insufficiently understood.Utilizing social information processing theory frameworks,the present study seeks to examine the sequential mediating roles of a cognitive factor,future orientation,and a behavioral factor,social withdrawal,in middle school students.Methods:A cross-sectional survey was administered in China,involving 528 participants(261 females and 267 males;Meanage=13.71,standard deviation[SD]=0.93).Participants completed self-report measures assessing peer victimization via the Delaware Bullying Victimization Scale-Student Version,NSSI via the Adolescents Self-Harm Scale,future orientation via the Adolescent Future Orientation Questionnaire,and social withdrawal via the Social Withdrawal Questionnaire.Results:Findings indicated a significant positive correlation between peer victimization and NSSI(r=0.30,p<0.01).Additionally,future orientation and social withdrawal functioned as serial mediators,with an indirect effect of 0.01(95%CI:[0.01,0.02]),representing 2.70%of the total effect(𝛽=0.37,95%CI:[0.25,0.47]).Conclusions:The findings endorse a theoretical framework in which negative future outlook and social withdrawal are sequentially linked within the relationship between peer victimization and NSSI.Although the serial indirect effect observed is modest,it delineates a distinct associative pattern that characterizes adolescents subjected to victimization.These results carry practical significance for school-based intervention programs,indicating that targeting future perspectives and social connections may enhance strategies for preventing NSSI.展开更多
Promoting the integration of industry and education and deepening school-enterprise cooperation in talent cultivation and collaborative innovation are long-term goals of higher education.This paper systematically anal...Promoting the integration of industry and education and deepening school-enterprise cooperation in talent cultivation and collaborative innovation are long-term goals of higher education.This paper systematically analyzes the multiple perspectives,practical challenges,and implementation paths of in-depth school-enterprise cooperation.Based on the typical case of school-enterprise cooperation at the School of Information and Software Engineering,University of Electronic Science and Technology of China(UESTC),this paper explores the innovative practices of in-depth school-enterprise cooperation in talent cultivation,scientific research,and faculty construction.It also explores a multi-party collaborative mechanism from the perspectives of universities,enterprises,students,and the government.By policy guidance,resource integration,and benefit sharing,this mechanism achieves in-depth integration of industry and education,providing references and examples for further development of school-enterprise cooperation in the new era.展开更多
Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understandi...Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understanding how best to preserve,build on its remarkable achievements,and develop its intellectual legacy.Critics such as Schumpeter and Taylor have long argued that the economic reasoning found in ancient China cannot compare with that of classical Greece or medieval Europe.Yet this view often reflects the narrow assumptions of mainstream economics,defining analysis almost entirely in terms of market exchange.As a result,it tends to overlook traditions built around statecraft,governance,and the management of economic order.A careful re-examination and Sino-Western comparative analysis of key thinkers-including Mencius,Guanzi,and Sima Qian-tells a different story.Rooted in China’s distinctive cultural and philosophical heritage,traditional Chinese economic thought not only contains the analytical dimensions(as defined by Schumpeter)but also displays a broader and more diverse set of economic reasoning.Notably,its systematic depth and intellectual precision were,in many respects,remarkably advanced.Therefore,advancing the construction of a Chinese school of economics in the new era under the framework of the“Second Integration”,i.e.,integrating the basic tenets of Marxism with China’s fine traditional culture,should,and indeed can draw essential insights from this analytical tradition.展开更多
The purpose of this study is to gain perspectives on introducing IBCTL(International Baccalaureate Certificate in Teaching and Learning)into graduate school of teacher education in Japan,which are currently providing ...The purpose of this study is to gain perspectives on introducing IBCTL(International Baccalaureate Certificate in Teaching and Learning)into graduate school of teacher education in Japan,which are currently providing advanced teacher training programs aimed at cultivating student agency,a comprehensive set of skills necessary for children living in the future,as advocated by the Organisation for Economic Co-operation and Development(OECD)Education 2030 Project.To achieve this goal,I examined the curriculum and structure that are important for IB teacher training and the introduction of IBCTL.I attempted to achieve this goal by examining the curriculum being developed at a graduate school of teacher education attempting to implement IBCTL and the creation of a syllabus based on that curriculum through lesson planning.As a result,I examined the curriculum and structure as a perspective for introducing IBCTL into graduate school of teacher education in Japan,where advanced teacher training is required.I found that a core curriculum and structure that incorporates the core of the IBCTL into the core of graduate school of teacher education programs is important for implementing an IB education that is aligned with the advancement of teacher training and the development of student agency.展开更多
Objectives:Psychological resilience is a critical resource for vocational high school students navigating social biases and fostering mental well-being.This six-month longitudinal study investigated the developmental ...Objectives:Psychological resilience is a critical resource for vocational high school students navigating social biases and fostering mental well-being.This six-month longitudinal study investigated the developmental trajectories of discrimination perception,vocational identity,and psychological resilience in this population.It further examined the longitudinal mediating role of vocational identity in the relationship between discrimination perception and psychological resilience.Methods:A total of 526 students from five vocational high schools in Guangdong,China,were assessed via convenience sampling at two time points:baseline(T1,September 2023)and six-month follow-up(T2,March 2024).Measures of discrimination perception,psychological resilience,and vocational identity were administered.Data were analyzed using a cross-lagged panel model to test for bidirectional relationships.Results:Over the six-month period,students showed significant decreases in discrimination perception and vocational identity,but a significant increase in psychological resilience.The cross-lagged model revealed significant bidirectional relationships:discrimination perception and psychological resilience negatively predicted each other over time(β=−0.124,p<0.01;β=−0.200,p<0.001),while psychological resilience and vocational identity positively predicted each other(β=0.084,p<0.05;β=0.076,p<0.05).The mediation analysis revealed a dual-pathway mechanism.T1 discrimination perception exerted both a significant direct negative effect on T2 psychological resilience(β=−0.332,p<0.001)and a significant indirect positive effect via T1 vocational identity(indirect effect=0.020,95%CI[0.001,0.046]).This confirms a partial mediating role,indicating that vocational identity functions as a compensatory mechanism,transforming the experience of discrimination perception into a potential source of psychological resilience.Conclusions:For vocational high school students,perception of discrimination directly undermines psychological resilience,but also indirectly fosters it through the positive development of vocational identity.These findings highlight vocational identity as a pivotal mechanism in the complex relationship between social adversity and mental resilience.展开更多
The rapid advancements in computer vision(CV)technology have transformed the traditional approaches to material microstructure analysis.This review outlines the history of CV and explores the applications of deep-lear...The rapid advancements in computer vision(CV)technology have transformed the traditional approaches to material microstructure analysis.This review outlines the history of CV and explores the applications of deep-learning(DL)-driven CV in four key areas of materials science:microstructure-based performance prediction,microstructure information generation,microstructure defect detection,and crystal structure-based property prediction.The CV has significantly reduced the cost of traditional experimental methods used in material performance prediction.Moreover,recent progress made in generating microstructure images and detecting microstructural defects using CV has led to increased efficiency and reliability in material performance assessments.The DL-driven CV models can accelerate the design of new materials with optimized performance by integrating predictions based on both crystal and microstructural data,thereby allowing for the discovery and innovation of next-generation materials.Finally,the review provides insights into the rapid interdisciplinary developments in the field of materials science and future prospects.展开更多
This study evaluated the physical development levels of preschool children across different districts of Chongqing,considering variations in age and gender,with the aim of proposing a differentiated physical education...This study evaluated the physical development levels of preschool children across different districts of Chongqing,considering variations in age and gender,with the aim of proposing a differentiated physical education curriculum implementation plan tailored to the differences in age,gender,and physical fitness levels among this population.A total of 1209 preschool children(46.89%girls)aged 3-6 years were tested on eight items:height,weight,standing long jump,10 m toss,seated forward bend,tennis ball toss,continuous jump on both feet and walking the balance beam.One-way variance,multiple comparisons and t-tests were used to calculate and express differences in their results.Overall,preschoolers(City)performed better than preschoolers(Country)in height and standing long jump,and preschoolers(Country)performed better than preschoolers(City)in continuous jumping on both feet.With the exception of the seated forward bend test,there were significant differences in the fitness levels of preschoolers by grade,with preschoolers of different genders(Boys)performing better than preschoolers(Girls)in height,weight,standing long jump and tennis throw.Preschoolers(Girls)performed better than preschoolers(Boys)in the 10 m toss and bend in a sitting position,and the gender differences were more pronounced with increasing age.展开更多
From the perspective of historical geography,this study conducts an in-depth investigation into the heritage timeline,regional characteristics,and formative factors of Longsha medical school(龙砂医派Longsha medicine)....From the perspective of historical geography,this study conducts an in-depth investigation into the heritage timeline,regional characteristics,and formative factors of Longsha medical school(龙砂医派Longsha medicine).Tracing its origin to the Song Dynasty,Longsha medicine has been handed down through successive generations,with numerous renowned physicians such as Xu Shuwei(许叔微)and Lu Wengui(陆文圭)making remarkable contributions to its development.A combination of favorable geographical location,superior ecological environment,an open cultural atmosphere,abundant local medicinal resources,and the unique physical constitutions of the local population comprehensively shaped the school’s distinct features and fueled its evolution.The core characteristics of Longsha medicine can be summarized as:emphasizing on inheritance and academic exploration,focusing on traditional Chinese medicine(TCM)classical theories and clinical practice,and embodying profound cultural connotations.As a regional and comprehensive TCM academic school,it originated in the Huashi area(historically known as Longsha)in Jiangyin County,Wuxi City,Jiangsu Province,gradually expanded to the areas surrounding Taihu Lake(太湖),and exerted far-reaching influence nationwide.Serving as a core representative of the TCM academic field in the Yangtze River Delta,Longsha medicine boasts a long history,solid cultural foundation,a galaxy of eminent physicians,classic works,distinct academic traits,unique diagnostic and therapeutic techniques,and vigorous dynamic inheritance.Contemporary in-depth research on Longsha medicine not only facilitates the dynamic inheritance of the core TCM theories such as Wu Yun Liu Qi(五运六气the five movements and six qi theory)in Huang Di Nei Jing(《黄帝内经》The Yellow Emperor’s Inner Classic)but also verifies the effectiveness and scientific validity of TCM classical theories in guiding the prevention and treatment of modern diseases.Thus,the study helps to protect regional medical-historical sources,enrich the doctrinal landscape of TCM,sustain distinctive academic techniques,catalyzes contemporary innovation,cultivates characteristic TCM talent,and enhances clinical service effectiveness.展开更多
With the in-depth advancement of vocational education reform,the concept of“Mass Entrepreneurship and Innovation”has emerged at the historic moment.Integrating“Mass Entrepreneurship and Innovation”education into t...With the in-depth advancement of vocational education reform,the concept of“Mass Entrepreneurship and Innovation”has emerged at the historic moment.Integrating“Mass Entrepreneurship and Innovation”education into the teaching of computer-related professional courses in vocational schools is conducive to cultivating high-quality applied talents.Based on this,this paper deeply analyzes the connotation and characteristics of“Mass Entrepreneurship and Innovation”education,and examines the current status and existing problems of integrating such education into computer-related professional courses.Furthermore,it proposes optimization strategies from aspects including the formulation of course objectives,the reconstruction of teaching content,the innovation of teaching methods,the development of teaching staff,and the construction of practical platforms.The purpose is to enhance students’innovative thinking,entrepreneurial capabilities,and professional skills,and to provide professional talents with“Mass Entrepreneurship and Innovation”literacy for the development of the computer industry.展开更多
Recent years have witnessed the ever-increasing performance of Deep Neural Networks(DNNs)in computer vision tasks.However,researchers have identified a potential vulnerability:carefully crafted adversarial examples ca...Recent years have witnessed the ever-increasing performance of Deep Neural Networks(DNNs)in computer vision tasks.However,researchers have identified a potential vulnerability:carefully crafted adversarial examples can easily mislead DNNs into incorrect behavior via the injection of imperceptible modification to the input data.In this survey,we focus on(1)adversarial attack algorithms to generate adversarial examples,(2)adversarial defense techniques to secure DNNs against adversarial examples,and(3)important problems in the realm of adversarial examples beyond attack and defense,including the theoretical explanations,trade-off issues and benign attacks in adversarial examples.Additionally,we draw a brief comparison between recently published surveys on adversarial examples,and identify the future directions for the research of adversarial examples,such as the generalization of methods and the understanding of transferability,that might be solutions to the open problems in this field.展开更多
This paper introduces an intelligent garbage-handling trolley model based on an STM32 single chip microcomputer as the control core.The device is driven by four independent motors to achieve automatic tracking,automat...This paper introduces an intelligent garbage-handling trolley model based on an STM32 single chip microcomputer as the control core.The device is driven by four independent motors to achieve automatic tracking,automatic obstacle avoidance,and fixed-point docking.Using external execution structure to realize the car without the use of a mechanical arm,complete garbage collection,storage,and uninstall function.On this basis,the type of garbage is marked by color,and the color recognition sensor is applied to realize the type recognition after garbage collection and put into the corresponding unloading point,to realize its intelligent classification function.It can automatically complete the established task autonomously.展开更多
Building a collaborative education mechanism,improving students’engineering practice and innovation abilities,and cultivating software engineering innovation talents that meet industry needs are of great significance...Building a collaborative education mechanism,improving students’engineering practice and innovation abilities,and cultivating software engineering innovation talents that meet industry needs are of great significance for fully implementing the“Excellent Engineer Education and Training Program”of the Ministry of Education and achieving the goal of building a strong engineering education country.The School of Information and Software Engineering of the University of Electronic Science and Technology of China(UESTC)has been thoroughly studying and implementing Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era and the spirit of the 20th CPC National Congress.The school has steadfastly promoted the Project of Nurturing the Soul of the New Era.The school has taken moral education as its core,deeply explored the resources of“all staff,throughout the process,in all aspects”,and constructed and implemented the collaborative education mechanism.These efforts have laid a solid foundation for cultivating excellent talents in software engineering in the new era.展开更多
Brain-computer interfaces(BCIs)represent an emerging technology that facilitates direct communication between the brain and external devices.In recent years,numerous review articles have explored various aspects of BC...Brain-computer interfaces(BCIs)represent an emerging technology that facilitates direct communication between the brain and external devices.In recent years,numerous review articles have explored various aspects of BCIs,including their fundamental principles,technical advancements,and applications in specific domains.However,these reviews often focus on signal processing,hardware development,or limited applications such as motor rehabilitation or communication.This paper aims to offer a comprehensive review of recent electroencephalogram(EEG)-based BCI applications in the medical field across 8 critical areas,encompassing rehabilitation,daily communication,epilepsy,cerebral resuscitation,sleep,neurodegenerative diseases,anesthesiology,and emotion recognition.Moreover,the current challenges and future trends of BCIs were also discussed,including personal privacy and ethical concerns,network security vulnerabilities,safety issues,and biocompatibility.展开更多
The advancement of Internet of Things(IoT)technology is driving industries toward intelligent digital transformation,highlighting the crucial role of software engineering.Despite this,the integration of software engin...The advancement of Internet of Things(IoT)technology is driving industries toward intelligent digital transformation,highlighting the crucial role of software engineering.Despite this,the integration of software engineering into IoT engineering education remains underexplored.To address this gap,the School of Software at North University of China,in collaboration with QST Innovation Technology Group Co.,Ltd.(QST),has developed an innovative educational mechanism.This initiative focuses on the software engineering IoT track and optimizes the teaching process through the outcome-based education(OBE)concept.It incorporates military-industrial characteristics,introduces advanced information and technology curricula,and enhances laboratory infrastructure.The goal is to cultivate innovative talents with unique capabilities,thereby fostering the comprehensive development and application of IoT technology.展开更多
Background:Parenting exerts a profound influence on children’s mental health and behavioral development.Despite the high prevalence of children’s emotional and behavioral problems(CEBP)in China,evidence-based parent...Background:Parenting exerts a profound influence on children’s mental health and behavioral development.Despite the high prevalence of children’s emotional and behavioral problems(CEBP)in China,evidence-based parenting interventions remain scarcely investigated as preventive public health strategies.This pilot study evaluated a school-based intervention for preventing CEBP.Methods:We employed a quasi-experimental design with propensity score matching(PSM)to select 28 families(intervention:n=13;control:n=15)from two matched urban primary schools.Quantitative data from seven validated scales were analyzed using t-tests and ANCOVA.Qualitative insights were derived from 10 semi-structured interviews via thematic analysis.Results:Compared to the control group,the intervention group demonstrated significantly greater improvements in CEBP(p=0.020,Cohen’s d=0.92),parental adjustment(p=0.031,Cohen’s d=0.80),parenting confidence(p=0.003,Cohen’s d=1.04),and parentchild relationships(p=0.001,Cohen’s d=1.46).Non-significant effects were observed for parenting style,parental relationship,and parenting conflict(p>0.05).Qualitative analysis corroborated these findings and further identified contributing factors for non-significant outcomes,including challengeswithmeasurement adaptability and inconsistent co-parenting practices.Conclusions:This pilot study suggests that an authoritative parenting style may be effective and culturally adaptable in China.Positive parenting interventions appear to mitigate CEBP by reducing risk factors and enhancing protective factors.However,improving parental relationships and parenting conflict may require targeted strategies.Given the pilot nature of this PSM-matched study(n=28),the findings should be interpreted as exploratory and used primarily for intervention refinement.展开更多
Background Clinical brain-computer interface(BCI)for mental disorders is an emerging interdisciplinary research field,posing new ethical concerns and challenges,yet lacking practical ethical governance guidelines for ...Background Clinical brain-computer interface(BCI)for mental disorders is an emerging interdisciplinary research field,posing new ethical concerns and challenges,yet lacking practical ethical governance guidelines for stakeholders and the entire community.Aims This study aims to establish a multidisciplinary consensus of principles for ethical governance of clinical BCI research for mental disorders and offer practical ethical guidance to stakeholders involved.Methods A systematic literature review,symposium and roundtable discussions,and a pre-Delphi(round 0)survey were conducted to form the questionnaire for the three-round modified Delphi study.Two rounds of surveys,followed by a third round of independent interviews of 25 experts from BCI-related research domains,were involved.We conducted quantitative analysis of responses and agreements among experts to reveal the consensus and differences regarding the ethical governance of mental BCI research from a multidisciplinary perspective.Results The Delphi panel emphasised important concerns of ethical review practices and ethical principles within the BCI context,identified qualified and highly influential institutions and personnel in conducting and advancing clinical BCI research,and recognised prioritised aspects in the risk-benefit evaluation.Experts expressed diverse opinions on specific ethical concerns,including concerns about invasive technology,its impact on humanity and potential social consequences.Agreement was reached that the practices of ethical governance of clinical BCI for mental disorders should focus on patient voluntariness,autonomy,long-term effects and related assessments of BCI interventions,as well as privacy protection,transparent reporting and ensuring that the research is conducted in qualified institutions with strong data security.Conclusions Ethical governance of clinical research on BCI for mental disorders should include interdisciplinary experts to balance various needs and incorporate the expertise of different stakeholders to avoid serious ethical issues.It requires scientifically grounded approaches,continuous monitoring and interdisciplinary collaboration to ensure evidence-based policies,comprehensive risk assessments and transparency,thereby promoting responsible innovations and protecting patient rights and well-being.展开更多
Stroke,particularly ischemic stroke,is the leading cause of long-term disability and mortality worldwide.It occurs due to the occlusion of the cerebral arteries,which significantly reduces the delivery of blood,oxygen...Stroke,particularly ischemic stroke,is the leading cause of long-term disability and mortality worldwide.It occurs due to the occlusion of the cerebral arteries,which significantly reduces the delivery of blood,oxygen,and essential nutrients to brain tissues.This deprivation triggers a cascade of cellular events that ultimately leads to neuronal death.Recent studies have clarified the multifactorial pathogenesis of ischemic stroke,highlighting the roles of energy failure,excitotoxicity,oxidative stress,neuroinflammation,and apoptosis.This review aimed to provide a comprehensive insight into the fundamental mechanisms driving neuronal death triggered by ischemia and to examine the progress of neuroprotective therapeutic approaches designed to mitigate neuronal loss and promote neurological recovery after a stroke.Additionally,we explored widely accepted findings regarding the potential pathways implicated in neuronal death during ischemic stroke,including the interplay of apoptosis,autophagy,pyroptosis,ferroptosis,and necrosis,which collectively influence neuronal fate.We also discussed advancements in neuroprotective therapeutics,encompassing a range of interventions from pharmacological modulation to stem cell-based therapies,aimed at reducing neuronal injury and enhancing functional recovery following ischemic stroke.Despite these advancements,challenges remain in translating mechanistic insights into effective clinical therapies.Although neuroprotective strategies have shown promise in preclinical models,their efficacy in human trials has been inconsistent,often due to the complex pathology of ischemic stroke and the timing of interventions.In conclusion,this review synthesizes mechanistic insights into the intricate interplay of molecular and cellular pathways driving neuronal death post-ischemia.It sheds light on cutting-edge advancements in potential neuroprotective therapeutics,underscores the promise of regenerative medicine,and offers a forward-looking perspective on potential clinical breakthroughs.The ongoing evolution of precision-targeted interventions is expected to significantly enhance preventative strategies and improve clinical outcomes.展开更多
Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesi...Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesics,including opioids and nonsteroidal anti-inflammatory drugs,are often limited by their insufficient efficacy,tolerance,and risk of dependence.Traditional Chinese Medicine(TCM),characterized by its multi-component,multi-target,and systemic regulatory properties,has shown promising potential in cancer pain management.This review provides a comprehensive overview of the clinical classification and underlying mechanisms of cancer pain(including nerve infiltration,dysregulation of inflammatory mediators and ion channels,central sensitization,neuro-immune crosstalk,metabolic reprogramming,and gut-brain axis impairment),as well as the analgesic effects of representative TCM agents in cancer pain management.For example,bioactive components such as tetrahydroberberine,levo-tetrahydropalmatine,and piperine exert analgesic effects,thereby improving the quality of life of patients by inhibiting inflammatory cascades,regulating neurotransmitter systems,and preserving neural integrity.Commonly used preclinical models,including bone cancer pain,pancreatic cancer pain,and chemotherapy-induced peripheral neuropathy models,are summarized for their utility in mechanistic studies and efficacy evaluations.This review also discusses the current limitations of clinical evidence,such as small sample sizes,short follow-up periods,and limited translation from animal models,alongside major challenges in standardization,mechanistic elucidation,and clinical trial design.Future directions should focus on precise pain phenotyping,integrated multi-target interventions,rigorous efficacy safety validation,and innovations in drug delivery to facilitate the standardization and global adoption of TCM in cancer pain management.展开更多
Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathologica...Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies.展开更多
基金supported by 2024 The Basic Ability Improvement Project for Young and Middle-aged Teachers of Colleges and Universities in Guangxi(No.2024KY0165)2024 Guangxi Minzu University General Research Project(Humanities and Social Sciences Category,No.2024MDSKYB20)2022 Annual Teaching and Research Project of Shiyuan College of Nanning Normal University(No.2022JY13).
文摘Objectives:Non-suicidal self-injury(NSSI)represents a prominent and escalating concern within mental health,associated with considerable psychological and physical dangers.Peer victimization is identified as a significant predictor of NSSI behavior.Although prior research has explored the association between peer victimization and NSSI,the mechanisms underlying this relationship remain insufficiently understood.Utilizing social information processing theory frameworks,the present study seeks to examine the sequential mediating roles of a cognitive factor,future orientation,and a behavioral factor,social withdrawal,in middle school students.Methods:A cross-sectional survey was administered in China,involving 528 participants(261 females and 267 males;Meanage=13.71,standard deviation[SD]=0.93).Participants completed self-report measures assessing peer victimization via the Delaware Bullying Victimization Scale-Student Version,NSSI via the Adolescents Self-Harm Scale,future orientation via the Adolescent Future Orientation Questionnaire,and social withdrawal via the Social Withdrawal Questionnaire.Results:Findings indicated a significant positive correlation between peer victimization and NSSI(r=0.30,p<0.01).Additionally,future orientation and social withdrawal functioned as serial mediators,with an indirect effect of 0.01(95%CI:[0.01,0.02]),representing 2.70%of the total effect(𝛽=0.37,95%CI:[0.25,0.47]).Conclusions:The findings endorse a theoretical framework in which negative future outlook and social withdrawal are sequentially linked within the relationship between peer victimization and NSSI.Although the serial indirect effect observed is modest,it delineates a distinct associative pattern that characterizes adolescents subjected to victimization.These results carry practical significance for school-based intervention programs,indicating that targeting future perspectives and social connections may enhance strategies for preventing NSSI.
文摘Promoting the integration of industry and education and deepening school-enterprise cooperation in talent cultivation and collaborative innovation are long-term goals of higher education.This paper systematically analyzes the multiple perspectives,practical challenges,and implementation paths of in-depth school-enterprise cooperation.Based on the typical case of school-enterprise cooperation at the School of Information and Software Engineering,University of Electronic Science and Technology of China(UESTC),this paper explores the innovative practices of in-depth school-enterprise cooperation in talent cultivation,scientific research,and faculty construction.It also explores a multi-party collaborative mechanism from the perspectives of universities,enterprises,students,and the government.By policy guidance,resource integration,and benefit sharing,this mechanism achieves in-depth integration of industry and education,providing references and examples for further development of school-enterprise cooperation in the new era.
基金supported by the National Social Science Fund of China(NSSFC):NSSFC Major Project“Exploration and Practice in the Development of Chinese Economics Since the Modern Era”(Grant No.17ZDA034)NSSFC Key Project“The Status and Value of Traditional Chinese Economic Thought”(Grant No.17AJL006)NSSFC General Project“The Transformation and Evolution of Chinese Economic Thought During the Republican Era”(Grant No.22BJL130).
文摘Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understanding how best to preserve,build on its remarkable achievements,and develop its intellectual legacy.Critics such as Schumpeter and Taylor have long argued that the economic reasoning found in ancient China cannot compare with that of classical Greece or medieval Europe.Yet this view often reflects the narrow assumptions of mainstream economics,defining analysis almost entirely in terms of market exchange.As a result,it tends to overlook traditions built around statecraft,governance,and the management of economic order.A careful re-examination and Sino-Western comparative analysis of key thinkers-including Mencius,Guanzi,and Sima Qian-tells a different story.Rooted in China’s distinctive cultural and philosophical heritage,traditional Chinese economic thought not only contains the analytical dimensions(as defined by Schumpeter)but also displays a broader and more diverse set of economic reasoning.Notably,its systematic depth and intellectual precision were,in many respects,remarkably advanced.Therefore,advancing the construction of a Chinese school of economics in the new era under the framework of the“Second Integration”,i.e.,integrating the basic tenets of Marxism with China’s fine traditional culture,should,and indeed can draw essential insights from this analytical tradition.
文摘The purpose of this study is to gain perspectives on introducing IBCTL(International Baccalaureate Certificate in Teaching and Learning)into graduate school of teacher education in Japan,which are currently providing advanced teacher training programs aimed at cultivating student agency,a comprehensive set of skills necessary for children living in the future,as advocated by the Organisation for Economic Co-operation and Development(OECD)Education 2030 Project.To achieve this goal,I examined the curriculum and structure that are important for IB teacher training and the introduction of IBCTL.I attempted to achieve this goal by examining the curriculum being developed at a graduate school of teacher education attempting to implement IBCTL and the creation of a syllabus based on that curriculum through lesson planning.As a result,I examined the curriculum and structure as a perspective for introducing IBCTL into graduate school of teacher education in Japan,where advanced teacher training is required.I found that a core curriculum and structure that incorporates the core of the IBCTL into the core of graduate school of teacher education programs is important for implementing an IB education that is aligned with the advancement of teacher training and the development of student agency.
基金supported by the Guangdong Provincial Philosophy and Social Science“14th Five-Year Plan”Discipline Co-Construction Project(Grant No.GD22XJY14)the 2022 Guangdong Provincial Higher Education Teaching Reform Project(Grant No.Yue Jiao Gao[2023]4)Guangdong Polytechnic Normal University’s Project for Enhancing the Research Capacity of Doctoral Application Institution(Grant No.22GPNUZDJS48).
文摘Objectives:Psychological resilience is a critical resource for vocational high school students navigating social biases and fostering mental well-being.This six-month longitudinal study investigated the developmental trajectories of discrimination perception,vocational identity,and psychological resilience in this population.It further examined the longitudinal mediating role of vocational identity in the relationship between discrimination perception and psychological resilience.Methods:A total of 526 students from five vocational high schools in Guangdong,China,were assessed via convenience sampling at two time points:baseline(T1,September 2023)and six-month follow-up(T2,March 2024).Measures of discrimination perception,psychological resilience,and vocational identity were administered.Data were analyzed using a cross-lagged panel model to test for bidirectional relationships.Results:Over the six-month period,students showed significant decreases in discrimination perception and vocational identity,but a significant increase in psychological resilience.The cross-lagged model revealed significant bidirectional relationships:discrimination perception and psychological resilience negatively predicted each other over time(β=−0.124,p<0.01;β=−0.200,p<0.001),while psychological resilience and vocational identity positively predicted each other(β=0.084,p<0.05;β=0.076,p<0.05).The mediation analysis revealed a dual-pathway mechanism.T1 discrimination perception exerted both a significant direct negative effect on T2 psychological resilience(β=−0.332,p<0.001)and a significant indirect positive effect via T1 vocational identity(indirect effect=0.020,95%CI[0.001,0.046]).This confirms a partial mediating role,indicating that vocational identity functions as a compensatory mechanism,transforming the experience of discrimination perception into a potential source of psychological resilience.Conclusions:For vocational high school students,perception of discrimination directly undermines psychological resilience,but also indirectly fosters it through the positive development of vocational identity.These findings highlight vocational identity as a pivotal mechanism in the complex relationship between social adversity and mental resilience.
基金financially supported by the National Science Fund for Distinguished Young Scholars,China(No.52025041)the National Natural Science Foundation of China(Nos.52450003,U2341267,and 52174294)+1 种基金the National Postdoctoral Program for Innovative Talents,China(No.BX20240437)the Fundamental Research Funds for the Central Universities,China(Nos.FRF-IDRY-23-037 and FRF-TP-20-02C2)。
文摘The rapid advancements in computer vision(CV)technology have transformed the traditional approaches to material microstructure analysis.This review outlines the history of CV and explores the applications of deep-learning(DL)-driven CV in four key areas of materials science:microstructure-based performance prediction,microstructure information generation,microstructure defect detection,and crystal structure-based property prediction.The CV has significantly reduced the cost of traditional experimental methods used in material performance prediction.Moreover,recent progress made in generating microstructure images and detecting microstructural defects using CV has led to increased efficiency and reliability in material performance assessments.The DL-driven CV models can accelerate the design of new materials with optimized performance by integrating predictions based on both crystal and microstructural data,thereby allowing for the discovery and innovation of next-generation materials.Finally,the review provides insights into the rapid interdisciplinary developments in the field of materials science and future prospects.
基金2024 Chongqing Vocational Education Teaching Reform Research Project(Project No.:Z2241594)2025 Project of The Science and Technology Research Program of the Chongqing Education Commission in China(Project No.:KJZD-K202502902)。
文摘This study evaluated the physical development levels of preschool children across different districts of Chongqing,considering variations in age and gender,with the aim of proposing a differentiated physical education curriculum implementation plan tailored to the differences in age,gender,and physical fitness levels among this population.A total of 1209 preschool children(46.89%girls)aged 3-6 years were tested on eight items:height,weight,standing long jump,10 m toss,seated forward bend,tennis ball toss,continuous jump on both feet and walking the balance beam.One-way variance,multiple comparisons and t-tests were used to calculate and express differences in their results.Overall,preschoolers(City)performed better than preschoolers(Country)in height and standing long jump,and preschoolers(Country)performed better than preschoolers(City)in continuous jumping on both feet.With the exception of the seated forward bend test,there were significant differences in the fitness levels of preschoolers by grade,with preschoolers of different genders(Boys)performing better than preschoolers(Girls)in height,weight,standing long jump and tennis throw.Preschoolers(Girls)performed better than preschoolers(Boys)in the 10 m toss and bend in a sitting position,and the gender differences were more pronounced with increasing age.
基金the grants from the second round of Construction Project of National Traditional Chinese Medicine Academic Schools Inheritance Studio of the State Administration of Traditional Chinese Medicine(No.62,2019)the Seventh Batch of National Projects for Inheriting Academic Experience of Veteran Traditional Chinese Medicine Experts(No.[2022]76)Construction Project of Lu Shu’s National Veteran Traditional Chinese Medicine Expert Inheritance Studio under the National Administration of Traditional Chinese Medicine(No.[2022]75).
文摘From the perspective of historical geography,this study conducts an in-depth investigation into the heritage timeline,regional characteristics,and formative factors of Longsha medical school(龙砂医派Longsha medicine).Tracing its origin to the Song Dynasty,Longsha medicine has been handed down through successive generations,with numerous renowned physicians such as Xu Shuwei(许叔微)and Lu Wengui(陆文圭)making remarkable contributions to its development.A combination of favorable geographical location,superior ecological environment,an open cultural atmosphere,abundant local medicinal resources,and the unique physical constitutions of the local population comprehensively shaped the school’s distinct features and fueled its evolution.The core characteristics of Longsha medicine can be summarized as:emphasizing on inheritance and academic exploration,focusing on traditional Chinese medicine(TCM)classical theories and clinical practice,and embodying profound cultural connotations.As a regional and comprehensive TCM academic school,it originated in the Huashi area(historically known as Longsha)in Jiangyin County,Wuxi City,Jiangsu Province,gradually expanded to the areas surrounding Taihu Lake(太湖),and exerted far-reaching influence nationwide.Serving as a core representative of the TCM academic field in the Yangtze River Delta,Longsha medicine boasts a long history,solid cultural foundation,a galaxy of eminent physicians,classic works,distinct academic traits,unique diagnostic and therapeutic techniques,and vigorous dynamic inheritance.Contemporary in-depth research on Longsha medicine not only facilitates the dynamic inheritance of the core TCM theories such as Wu Yun Liu Qi(五运六气the five movements and six qi theory)in Huang Di Nei Jing(《黄帝内经》The Yellow Emperor’s Inner Classic)but also verifies the effectiveness and scientific validity of TCM classical theories in guiding the prevention and treatment of modern diseases.Thus,the study helps to protect regional medical-historical sources,enrich the doctrinal landscape of TCM,sustain distinctive academic techniques,catalyzes contemporary innovation,cultivates characteristic TCM talent,and enhances clinical service effectiveness.
文摘With the in-depth advancement of vocational education reform,the concept of“Mass Entrepreneurship and Innovation”has emerged at the historic moment.Integrating“Mass Entrepreneurship and Innovation”education into the teaching of computer-related professional courses in vocational schools is conducive to cultivating high-quality applied talents.Based on this,this paper deeply analyzes the connotation and characteristics of“Mass Entrepreneurship and Innovation”education,and examines the current status and existing problems of integrating such education into computer-related professional courses.Furthermore,it proposes optimization strategies from aspects including the formulation of course objectives,the reconstruction of teaching content,the innovation of teaching methods,the development of teaching staff,and the construction of practical platforms.The purpose is to enhance students’innovative thinking,entrepreneurial capabilities,and professional skills,and to provide professional talents with“Mass Entrepreneurship and Innovation”literacy for the development of the computer industry.
基金Supported by the National Natural Science Foundation of China(U1903214,62372339,62371350,61876135)the Ministry of Education Industry University Cooperative Education Project(202102246004,220800006041043,202002142012)the Fundamental Research Funds for the Central Universities(2042023kf1033)。
文摘Recent years have witnessed the ever-increasing performance of Deep Neural Networks(DNNs)in computer vision tasks.However,researchers have identified a potential vulnerability:carefully crafted adversarial examples can easily mislead DNNs into incorrect behavior via the injection of imperceptible modification to the input data.In this survey,we focus on(1)adversarial attack algorithms to generate adversarial examples,(2)adversarial defense techniques to secure DNNs against adversarial examples,and(3)important problems in the realm of adversarial examples beyond attack and defense,including the theoretical explanations,trade-off issues and benign attacks in adversarial examples.Additionally,we draw a brief comparison between recently published surveys on adversarial examples,and identify the future directions for the research of adversarial examples,such as the generalization of methods and the understanding of transferability,that might be solutions to the open problems in this field.
文摘This paper introduces an intelligent garbage-handling trolley model based on an STM32 single chip microcomputer as the control core.The device is driven by four independent motors to achieve automatic tracking,automatic obstacle avoidance,and fixed-point docking.Using external execution structure to realize the car without the use of a mechanical arm,complete garbage collection,storage,and uninstall function.On this basis,the type of garbage is marked by color,and the color recognition sensor is applied to realize the type recognition after garbage collection and put into the corresponding unloading point,to realize its intelligent classification function.It can automatically complete the established task autonomously.
文摘Building a collaborative education mechanism,improving students’engineering practice and innovation abilities,and cultivating software engineering innovation talents that meet industry needs are of great significance for fully implementing the“Excellent Engineer Education and Training Program”of the Ministry of Education and achieving the goal of building a strong engineering education country.The School of Information and Software Engineering of the University of Electronic Science and Technology of China(UESTC)has been thoroughly studying and implementing Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era and the spirit of the 20th CPC National Congress.The school has steadfastly promoted the Project of Nurturing the Soul of the New Era.The school has taken moral education as its core,deeply explored the resources of“all staff,throughout the process,in all aspects”,and constructed and implemented the collaborative education mechanism.These efforts have laid a solid foundation for cultivating excellent talents in software engineering in the new era.
基金supported by the National Key R&D Program of China(2021YFF1200602)the National Science Fund for Excellent Overseas Scholars(0401260011)+3 种基金the National Defense Science and Technology Innovation Fund of Chinese Academy of Sciences(c02022088)the Tianjin Science and Technology Program(20JCZDJC00810)the National Natural Science Foundation of China(82202798)the Shanghai Sailing Program(22YF1404200).
文摘Brain-computer interfaces(BCIs)represent an emerging technology that facilitates direct communication between the brain and external devices.In recent years,numerous review articles have explored various aspects of BCIs,including their fundamental principles,technical advancements,and applications in specific domains.However,these reviews often focus on signal processing,hardware development,or limited applications such as motor rehabilitation or communication.This paper aims to offer a comprehensive review of recent electroencephalogram(EEG)-based BCI applications in the medical field across 8 critical areas,encompassing rehabilitation,daily communication,epilepsy,cerebral resuscitation,sleep,neurodegenerative diseases,anesthesiology,and emotion recognition.Moreover,the current challenges and future trends of BCIs were also discussed,including personal privacy and ethical concerns,network security vulnerabilities,safety issues,and biocompatibility.
基金supported in part by the Universityindustry Collaborative Education Program of the Ministry of Education under Grant No.202102383004。
文摘The advancement of Internet of Things(IoT)technology is driving industries toward intelligent digital transformation,highlighting the crucial role of software engineering.Despite this,the integration of software engineering into IoT engineering education remains underexplored.To address this gap,the School of Software at North University of China,in collaboration with QST Innovation Technology Group Co.,Ltd.(QST),has developed an innovative educational mechanism.This initiative focuses on the software engineering IoT track and optimizes the teaching process through the outcome-based education(OBE)concept.It incorporates military-industrial characteristics,introduces advanced information and technology curricula,and enhances laboratory infrastructure.The goal is to cultivate innovative talents with unique capabilities,thereby fostering the comprehensive development and application of IoT technology.
基金supported by the National Social Science Fund of China[18BSH146].
文摘Background:Parenting exerts a profound influence on children’s mental health and behavioral development.Despite the high prevalence of children’s emotional and behavioral problems(CEBP)in China,evidence-based parenting interventions remain scarcely investigated as preventive public health strategies.This pilot study evaluated a school-based intervention for preventing CEBP.Methods:We employed a quasi-experimental design with propensity score matching(PSM)to select 28 families(intervention:n=13;control:n=15)from two matched urban primary schools.Quantitative data from seven validated scales were analyzed using t-tests and ANCOVA.Qualitative insights were derived from 10 semi-structured interviews via thematic analysis.Results:Compared to the control group,the intervention group demonstrated significantly greater improvements in CEBP(p=0.020,Cohen’s d=0.92),parental adjustment(p=0.031,Cohen’s d=0.80),parenting confidence(p=0.003,Cohen’s d=1.04),and parentchild relationships(p=0.001,Cohen’s d=1.46).Non-significant effects were observed for parenting style,parental relationship,and parenting conflict(p>0.05).Qualitative analysis corroborated these findings and further identified contributing factors for non-significant outcomes,including challengeswithmeasurement adaptability and inconsistent co-parenting practices.Conclusions:This pilot study suggests that an authoritative parenting style may be effective and culturally adaptable in China.Positive parenting interventions appear to mitigate CEBP by reducing risk factors and enhancing protective factors.However,improving parental relationships and parenting conflict may require targeted strategies.Given the pilot nature of this PSM-matched study(n=28),the findings should be interpreted as exploratory and used primarily for intervention refinement.
基金funded by the Shanghai Philosophy and Social Science Planning Project (2021BZX008)the National Social Science Foundation of China (23BZX110)the National Office for Philosophy and Social Science (20&ZD045).
文摘Background Clinical brain-computer interface(BCI)for mental disorders is an emerging interdisciplinary research field,posing new ethical concerns and challenges,yet lacking practical ethical governance guidelines for stakeholders and the entire community.Aims This study aims to establish a multidisciplinary consensus of principles for ethical governance of clinical BCI research for mental disorders and offer practical ethical guidance to stakeholders involved.Methods A systematic literature review,symposium and roundtable discussions,and a pre-Delphi(round 0)survey were conducted to form the questionnaire for the three-round modified Delphi study.Two rounds of surveys,followed by a third round of independent interviews of 25 experts from BCI-related research domains,were involved.We conducted quantitative analysis of responses and agreements among experts to reveal the consensus and differences regarding the ethical governance of mental BCI research from a multidisciplinary perspective.Results The Delphi panel emphasised important concerns of ethical review practices and ethical principles within the BCI context,identified qualified and highly influential institutions and personnel in conducting and advancing clinical BCI research,and recognised prioritised aspects in the risk-benefit evaluation.Experts expressed diverse opinions on specific ethical concerns,including concerns about invasive technology,its impact on humanity and potential social consequences.Agreement was reached that the practices of ethical governance of clinical BCI for mental disorders should focus on patient voluntariness,autonomy,long-term effects and related assessments of BCI interventions,as well as privacy protection,transparent reporting and ensuring that the research is conducted in qualified institutions with strong data security.Conclusions Ethical governance of clinical research on BCI for mental disorders should include interdisciplinary experts to balance various needs and incorporate the expertise of different stakeholders to avoid serious ethical issues.It requires scientifically grounded approaches,continuous monitoring and interdisciplinary collaboration to ensure evidence-based policies,comprehensive risk assessments and transparency,thereby promoting responsible innovations and protecting patient rights and well-being.
基金supported by the National Natural Science Foundation of China,Nos.82171387 and 31830111(both to SL).
文摘Stroke,particularly ischemic stroke,is the leading cause of long-term disability and mortality worldwide.It occurs due to the occlusion of the cerebral arteries,which significantly reduces the delivery of blood,oxygen,and essential nutrients to brain tissues.This deprivation triggers a cascade of cellular events that ultimately leads to neuronal death.Recent studies have clarified the multifactorial pathogenesis of ischemic stroke,highlighting the roles of energy failure,excitotoxicity,oxidative stress,neuroinflammation,and apoptosis.This review aimed to provide a comprehensive insight into the fundamental mechanisms driving neuronal death triggered by ischemia and to examine the progress of neuroprotective therapeutic approaches designed to mitigate neuronal loss and promote neurological recovery after a stroke.Additionally,we explored widely accepted findings regarding the potential pathways implicated in neuronal death during ischemic stroke,including the interplay of apoptosis,autophagy,pyroptosis,ferroptosis,and necrosis,which collectively influence neuronal fate.We also discussed advancements in neuroprotective therapeutics,encompassing a range of interventions from pharmacological modulation to stem cell-based therapies,aimed at reducing neuronal injury and enhancing functional recovery following ischemic stroke.Despite these advancements,challenges remain in translating mechanistic insights into effective clinical therapies.Although neuroprotective strategies have shown promise in preclinical models,their efficacy in human trials has been inconsistent,often due to the complex pathology of ischemic stroke and the timing of interventions.In conclusion,this review synthesizes mechanistic insights into the intricate interplay of molecular and cellular pathways driving neuronal death post-ischemia.It sheds light on cutting-edge advancements in potential neuroprotective therapeutics,underscores the promise of regenerative medicine,and offers a forward-looking perspective on potential clinical breakthroughs.The ongoing evolution of precision-targeted interventions is expected to significantly enhance preventative strategies and improve clinical outcomes.
基金supported by the National Natural Science Foundation of China(No.82360238,82071245)。
文摘Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesics,including opioids and nonsteroidal anti-inflammatory drugs,are often limited by their insufficient efficacy,tolerance,and risk of dependence.Traditional Chinese Medicine(TCM),characterized by its multi-component,multi-target,and systemic regulatory properties,has shown promising potential in cancer pain management.This review provides a comprehensive overview of the clinical classification and underlying mechanisms of cancer pain(including nerve infiltration,dysregulation of inflammatory mediators and ion channels,central sensitization,neuro-immune crosstalk,metabolic reprogramming,and gut-brain axis impairment),as well as the analgesic effects of representative TCM agents in cancer pain management.For example,bioactive components such as tetrahydroberberine,levo-tetrahydropalmatine,and piperine exert analgesic effects,thereby improving the quality of life of patients by inhibiting inflammatory cascades,regulating neurotransmitter systems,and preserving neural integrity.Commonly used preclinical models,including bone cancer pain,pancreatic cancer pain,and chemotherapy-induced peripheral neuropathy models,are summarized for their utility in mechanistic studies and efficacy evaluations.This review also discusses the current limitations of clinical evidence,such as small sample sizes,short follow-up periods,and limited translation from animal models,alongside major challenges in standardization,mechanistic elucidation,and clinical trial design.Future directions should focus on precise pain phenotyping,integrated multi-target interventions,rigorous efficacy safety validation,and innovations in drug delivery to facilitate the standardization and global adoption of TCM in cancer pain management.
文摘Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies.
