Coal dust explosions are severe safety accidents in coal mine production,posing significant threats to life and property.Predicting the maximum explosion pressure(Pm)of coal dust using deep learning models can effecti...Coal dust explosions are severe safety accidents in coal mine production,posing significant threats to life and property.Predicting the maximum explosion pressure(Pm)of coal dust using deep learning models can effectively assess potential risks and provide a scientific basis for preventing coal dust explosions.In this study,a 20-L explosion sphere apparatus was used to test the maximum explosion pressure of coal dust under seven different particle sizes and ten mass concentrations(Cdust),resulting in a dataset of 70 experimental groups.Through Spearman correlation analysis and random forest feature selection methods,particle size(D_(10),D_(20),D_(50))and mass concentration(Cdust)were identified as critical feature parameters from the ten initial parameters of the coal dust samples.Based on this,a hybrid Long Short-Term Memory(LSTM)network model incorporating a Multi-Head Attention Mechanism and the Sparrow Search Algorithm(SSA)was proposed to predict the maximum explosion pressure of coal dust.The results demonstrate that the SSA-LSTM-Multi-Head Attention model excels in predicting the maximum explosion pressure of coal dust.The four evaluation metrics indicate that the model achieved a coefficient of determination(R^(2)),root mean square error(RMSE),mean absolute percentage error(MAPE),and mean absolute error(MAE)of 0.9841,0.0030,0.0074,and 0.0049,respectively,in the training set.In the testing set,these values were 0.9743,0.0087,0.0108,and 0.0069,respectively.Compared to artificial neural networks(ANN),random forest(RF),support vector machines(SVM),particle swarm optimized-SVM(PSO-SVM)neural networks,and the traditional single-model LSTM,the SSA-LSTM-Multi-Head Attention model demonstrated superior generalization capability and prediction accuracy.The findings of this study not only advance the application of deep learning in coal dust explosion prediction but also provide robust technical support for the prevention and risk assessment of coal dust explosions.展开更多
Background:Bordetella pertussis,the causative agent of whooping cough,is a significant contributor to recurrent persistent cough across all age groups,including vaccinated individuals.This seroepidemiological study ai...Background:Bordetella pertussis,the causative agent of whooping cough,is a significant contributor to recurrent persistent cough across all age groups,including vaccinated individuals.This seroepidemiological study aims to address the gap in understanding pertussis incidence by investigating its occurrence in individuals with persistent cough and describing the characteristics of affected patients admitted to clinical centers in Jahrom,Southwest Iran.Methods:This cross-sectional study enrolled 110 patients with a cough persisting for at least 2 weeks,admitted to clinical centers in Jahrom,Iran.Blood samples were collected at baseline and on day 21 of follow-up.Serum samples were analyzed for anti-pertussis toxin immunoglobulin G(anti-PT-IgG)levels using an enzyme-linked immunosorbent assay.Demographic factors,including age,gender,occupation,area of residence,and family size,were also evaluated.Results:Among the 110 participants,77(70%)were female,and seven patients(6.4%)tested seropositive for anti-PT-IgG.No significant associations were observed between pertussis incidence and the analyzed variables,including age,gender,occupation,area of residence(urban vs.rural),and family size(p>0.05).These findings underscore the importance of enhancing vaccination coverage to reduce the prevalence of B.pertussis in the community.Conclusion:This study highlights the occurrence of pertussis in individuals presenting solely with a persistent cough,absent of classic symptoms.The findings emphasize the need for healthcare providers to conduct detailed assessments and utilize rapid diagnostic methods for timely detection.This is particularly crucial in regions with high vaccination rates but limited awareness of pertussis recurrence.展开更多
Suzhou City,located in the Yangtze River Delta in China,is prone to flooding due to a complex combination of natural factors,including its monsoon climate,low elevation,and tidally influenced position,as well as inten...Suzhou City,located in the Yangtze River Delta in China,is prone to flooding due to a complex combination of natural factors,including its monsoon climate,low elevation,and tidally influenced position,as well as intensive human activities.The Large Encirclement Flood Control Project(LEFCP)was launched to cope with serious floods in the urban area.This project changed the spatiotemporal pattern of flood processes and caused spatial diversion of floods from the urban area to the outskirts of the city.Therefore,this study developed a distributed flood simulation model in order to understand this transition of flood processes.The results revealed that the LEFCP effectively protected the urban areas from floods,but the present scheduling schemes resulted in the spatial diversion of floods to the outskirts of the city.With rainstorm frequencies of 10.0%to 0.5%,the water level differences between two representative water level stations(Miduqiao(MDQ)and Fengqiao(FQ))located inside and outside the LEFCP area,ranged from 0.75 m to 0.24 m and from 1.80 m to 1.58 m,respectively.In addition,the flood safety margin at MDQ and the duration with the water level exceeding the warning water level at FQ ranged from 0.95 m to 0.43 m and from 4 h to 22 h,respectively.Rational scheduling schemes for the hydraulic facilities of the LEFCP in extreme precipitation cases were developed ac-cording to food simulations under seven scheduling scenarios.This helps to regulate the spatial flood diversion caused by the LEFCP during extreme precipitation.展开更多
While the development of particular video segmentation algorithms has attracted considerable research interest, relatively little effort has been devoted to provide a methodology for evaluating their performance. In t...While the development of particular video segmentation algorithms has attracted considerable research interest, relatively little effort has been devoted to provide a methodology for evaluating their performance. In this paper, we propose a methodology to objectively evaluate video segmentation algorithm with ground-truth, which is based on computing the deviation of segmentation results from the reference segmentation. Four different metrics based on classification pixels, edges, relative foreground area and relative position respectively are combined to address the spatial accuracy. Temporal coherency is evaluated by utilizing the difference of spatial accuracy between successive frames. The experimental results show the feasibility of our approach. Moreover, it is computationally more efficient than previous methods. It can be applied to provide an offline ranking among different segmentation algorithms and to optimally set the parameters for a given algorithm.展开更多
At present, unified and effective treatment for hypertension with insomnia is still lacking, traditional Chinese medicine (TCM) nursing technology can improve insomnia symptoms, reduce blood pressure, alleviate fatigu...At present, unified and effective treatment for hypertension with insomnia is still lacking, traditional Chinese medicine (TCM) nursing technology can improve insomnia symptoms, reduce blood pressure, alleviate fatigue, improve anxiety, depression, improve the quality of life for patients with hypertension and insomnia. There is not only the application of the single TCM nursing technology, such as acupoint massage, acupoint application, ear acupoint pressure beans and so on, but also the application of two or a variety of TCM nursing techniques in hypertension with insomnia. In this article, the results of TCM nursing technology on hypertension with insomnia in recent years are reviewed in order to provide reference for the treatment of hypertensive with insomnia.展开更多
Applying the air impact molding method to mold the complicated pattern with wider opening surface and deeper concave, there always exist vaulted phenomenon and lower compactibility of sand mold over the entrance and t...Applying the air impact molding method to mold the complicated pattern with wider opening surface and deeper concave, there always exist vaulted phenomenon and lower compactibility of sand mold over the entrance and the concave regions. Using the air-stream and synchro-formed clamp plate impact molding, however, this problem will be preferably solved. In this paper, the compact mechanism of the new molding method and the effect of some configuration factors, such as the area flowed by compressed air and the highness of the protruding block displacement around the diffluent clamp plate, on the compactibility of sand mold were discussed.展开更多
The key to carry out ICAD technology is to establish the knowledge-based and wide rang of domains-covered product model.This paper put out a knowledge-based methodology of adaptive modeling.It is under the Ontology mi...The key to carry out ICAD technology is to establish the knowledge-based and wide rang of domains-covered product model.This paper put out a knowledge-based methodology of adaptive modeling.It is under the Ontology mind,using the Object-Oriented technology and being a knowledge-based model framework.It involves the diverse domains in product design and realizes the multi-domain modeling,embedding the relative information including standards,regulars and expert experience.To test the feasibility of the methodology,the research bonds of the automotive diaphragm spring clutch design and an adaptive clutch design model is established,using the knowledge-based modeling language-AML.展开更多
This paper discusses the single-machine rescheduling problem with efficiency and stability as criteria, where more than one disruption arises in large-scale dynamic circumstances. Partial rescheduling (PR) strategy is...This paper discusses the single-machine rescheduling problem with efficiency and stability as criteria, where more than one disruption arises in large-scale dynamic circumstances. Partial rescheduling (PR) strategy is adopted after each disruption and a rolling mechanism is driven by events in response to disruptions. Two kinds of objective functions are designed respectively for PR sub-problem involving in the interim and the terminal of unfinished jobs. The analytical result demonstrates that each local objective is consistent with the global one. Extensive computational experiment was performed and the computational results show that the rolling PR strategy with dual objectives can greatly improve schedule stability with little sacrifice in efficiency and provide a reasonable trade-off between solution quality and computational efforts.展开更多
Background Educational inequalities in suicide have become increasingly prominent over the past decade.Elucidating modifiable risk factors that serve as intermediaries in the impact of low educational attainment on su...Background Educational inequalities in suicide have become increasingly prominent over the past decade.Elucidating modifiable risk factors that serve as intermediaries in the impact of low educational attainment on suicide has the potential to reduce health disparities.Aims To examine the risk factors that mediate the relationship between educational attainment and suicide attempts and quantify their contributions to the mediation effect.Methods We conducted a two-sample Mendelian randomisation(MR)analysis to estimate the causal effect of educational attainment on suicide attempts,utilising genome-wide association study summary statistics from the Integrative Psychiatric Research(iPSYCH;6024 cases and 44240 controls)and FinnGen(8978 cases and 368299 controls).We systematically evaluated 42 putative mediators within the causal pathway connecting reduced educational attainment to suicide attempts and employed two-step and multivariable MR to quantify the proportion of the mediated effect.Results In the combined analysis of iPSYCH and FinnGen,each standard deviation(SD)decrease in genetically predicted educational attainment(equating to 3.4 years of education)was associated with a 105%higher risk of suicide attempts(odds ratio(OR):2.05;95%confidence interval(Cl):1.81 to 2.31).0f the 42 risk factors analysed,the two-step MR identified five factors that mediated the association between educational attainment and suicide attempts.The respective proportions of mediation were 47%(95%Cl:29%to 66%)for smoking behaviour,36%(95%Cl:0%to 84%)for chronic pain,49%(95%Cl:36%to 61%)for depression,35%(95%Cl:12%to 59%)for anxiety and 26%(95%Cl:18%to 34%)for insomnia.Multivariable MR implicated these five mediators collectively,accounting for 68%(95%Cl:40%to 96%)of the total effect.Conclusions This study identified smoking,chronic pain and mental disorders as primary intervention targets for attenuating suicide risk attributable to lower educational levels in the European population.展开更多
Genomic sources from China are underrepresented in the population-specific reference database.We performed whole-genome sequencing or genome-wide genotyping on 1,207 individuals from four linguistically diverse groups...Genomic sources from China are underrepresented in the population-specific reference database.We performed whole-genome sequencing or genome-wide genotyping on 1,207 individuals from four linguistically diverse groups(1,081 Sinitic,56 Mongolic,40 Turkic,and 30Tibeto-Burman people)living in North China included in the 10K Chinese People Genomic Diversity Project(10K_CPGDP)to characterize the genetic architecture and adaptative history of ethnic groups in the Silk Road Region of China.We observed a population split between Northwest Chinese minorities(NWCMs)and Han Chinese since the Upper Paleolithic and later Neolithic genetic differentiation within NWCMs.The observed population substructures among ethnically/linguistically diverse NWCMs suggested that differentiated admixture events contributed to the differences in their genomic and phenotypic diversity.We estimated that the Dongxiang,Tibetan,and Yugur people inherited more than 10%of the Western Eurasian ancestry,which is much greater than that of the Salar and Tu people(<7%),while Han neighbors showed less West Eurasian ancestry(~1%-3%).Male-biased admixture introduced Western Eurasian ancestry in the Dongxiang,Tibetan,and Yugur populations.We found that the eastern-western admixture in NWCMs occurred~800-1,100 years ago,coinciding with intensive economic and cultural exchanges during the Tang and Song dynasties.Additionally,we identified the signatures of natural selection associated with cardiovascular system diseases or lipid metabolism and developmental/neurogenetic disorders.Moreover,the EPAS1 gene showed relatively high population branch statistic values in NWCMs.The well-fitted demographical models presented the vast landscape of complex admixture processes of the Silk Road people,and the newly reported functionally important variations suggested the importance of including ethnolinguistically diverse populations in Chinese genetic studies for uncovering the genetic basis of complex traits/diseases.展开更多
Due to the lack of gas-solid radial mixing in conventional spouted bed(CSB),particles are prone to accumulation and the formation of flow dead zones.To address the limitations of CSBs,this study,for the first time,the...Due to the lack of gas-solid radial mixing in conventional spouted bed(CSB),particles are prone to accumulation and the formation of flow dead zones.To address the limitations of CSBs,this study,for the first time,the combination optimization of the two strengthening internal components of multi-jets and draft tube was carried out,and two new types of internal strengthening structural spouted beds were proposed:the Integral Multi-jets Draft-tube Spout-fluidized Bed(IMDSFB),and the Integral Multi-jets Open-hole Draft-tube Spout-fluidized Bed(IMODSFB).At the same time,the hydrodynamic character-istics of IMDSFB and IMODSFB are studied by numerical simulation for the first time and compared with the draft tube spouted bed(DTSB)and CSB.Results indicate that compared to CSB,the spouting heights of the DTSB,IMDSFB,and IMODSFB were enhanced by 2.92%,14.75%,and 7.94%,respectively,and the dead zone of the DTSB,IMDSFB,and IMODSFB decreased by 14%,1%,and 5%,respectively.Compared to the CSB and DTSB,the addition of novel internal components notably improved the radial velocities of both gas and particles,as well as the gas-solid slip velocity,while reducing flow dead zones within the bed.Furthermore,the gas turbulence kinetic energy in the novel spout-fluidized beds was higher,with increased fluctuations of gas velocity in the spouting region.The granular temperature in the IMDSFB and IMODSFB was higher than in the CSB and DTSB,indicating enhanced particle fluctuations within the bed.These improvements contribute to more efficient gas-solid phase interactions,thereby enhancing the overall performance of the spouted bed.展开更多
In this paper,we show by Hilbert Uniqueness Method that the boundary value problem of fifth-order KdV equation{y_(t)-y_(5x)=0,(x,t)∈(0,2π)×(0,T),y(t,2π)-y(t,0)=h_(0)(t),y_(x)(t,2π)-y_(x)(t,0)=h_(1)(t),y_(2x)(...In this paper,we show by Hilbert Uniqueness Method that the boundary value problem of fifth-order KdV equation{y_(t)-y_(5x)=0,(x,t)∈(0,2π)×(0,T),y(t,2π)-y(t,0)=h_(0)(t),y_(x)(t,2π)-y_(x)(t,0)=h_(1)(t),y_(2x)(t,2π)-y_(2x)(t,0)=h_(2)(t),y_(3x)(t,2π)-y_(3x)(t,0)=h_(3)(t),y_(4x)(t,2π)-y_(4x)(t,0)=h_(4)(t),(with boundary data as control inputs)is exact controllability.展开更多
In this study,the physical properties of F ion-implanted GaN were thoroughly studied,and the related electric-field modulation mechanisms in ion-implanted edge termination were revealed.Transmission electron microscop...In this study,the physical properties of F ion-implanted GaN were thoroughly studied,and the related electric-field modulation mechanisms in ion-implanted edge termination were revealed.Transmission electron microscopy re.sults indicate that the ion-implanted region maintains a single-crystal structure even with the implantation of high-energy F ions,indicating that the high resistivity of the edge termination region is not induced by amorphization.Alternately,ion implantation-induced deep levels could compensate the electrons and lead to a highly resistive layer In addition to the bulk ffect,the direct bombardment of high-energy F ions resulted in a rough and nitrogen-deficient surface,which was confirmed via atomic force microscopy(AFM)and X-ray photoelectron spectroscopy,The implanted surface with a large density of nitrogen vacancies can accommodate electrons,and it is more conductive than the bulk in the implanted region,which is validated via spreading resistance profiling and conductive AFM measurements.Under reverse bias,the implanted surface can spread the potential in the lateral direction,whereas the acceptor traps capture electrons acting as space charges,shifting the peak electric field into the bulk region in the vertical direction.As a result,the Schottky barrier diode terminated with high-energy F ion-implanted regions exhibits a breakdown voltage of over 1.2 kv.展开更多
Parpose:The study aims to compare the efficacy and safety of a new minimally invasive osteosynthesis technique with those of conventional open surgery for transverse patellar fractures.Methods:It was a retrospective s...Parpose:The study aims to compare the efficacy and safety of a new minimally invasive osteosynthesis technique with those of conventional open surgery for transverse patellar fractures.Methods:It was a retrospective study.Adult patients with closed transverse patellar fracture were included,and with open comminuted patellar fracture were excluded.These patients were divided into minimally invasive osteosynthesis technique(MIOT)group and open reduction and internal fixation(ORIF)group.Surgical time,frequency of intraoperative fluoroscopy,visual analogue scale score,flexion,extension,Lysholm knee score,infection,malreduction,implant migration and implant irritation in two groups were recorded and compared.Statistical analysis was performed by the SPsS software package(version 19).A p<0.05 indicated statistical significance.Results:A total of 55 patients with transverse patellar fractures enrolled in this study,the minimally invasive technique was performed in 27 cases,and open reduction was performed in 28 cases.The surgical time in the ORIF group was shorter than that in the MIOT group(p=0.033).The visual analogue scale scores in the MIOT group were significantly lower than those in the ORIF group only in the first month after surgery(p=0.015).Flexion was restored faster in the MIOT group than that in the ORIF group at one month(p=0.001)and three months(p=0.015).Extension was recovered faster in the MIOT group than that in the ORIF group at one month(p=0.031)and three months(p=0.023).The recorded Lysholm knee scores in the MIOT group were always greater than those in the ORIF group.Complications,such as infection,malreduction,implant migration,and implant irritation,occurred more frequently in the ORIF group.Conclusion:Compared with the ORIF group,the MIOT group reduced postoperative pain and had less complications and better exercise rehabilitation.Although it requires a long operation time,MIOT may be a wise choice for transverse patellar fractures.展开更多
Background:Programmed cell death 1(PD-1)and programmed cell death ligand 1(PD-L1)inhibitors have become integral elements within the current landscape of breast cancer treatment modalities;however,they are associ-ated...Background:Programmed cell death 1(PD-1)and programmed cell death ligand 1(PD-L1)inhibitors have become integral elements within the current landscape of breast cancer treatment modalities;however,they are associ-ated with interstitial lung disease(ILD),which is rare but potentially fatal.Notably,only a few studies have compared the difference in ILD incidence between PD-1 and PD-L1 inhibitors.Therefore,this study aimed to assess the discrepancies regarding ILD risk between the two immune checkpoint inhibitors.We also reported three cases of ILD after PD-1 inhibitor treatment.Methods:We comprehensively searched PubMed,EMBASE,and the Cochrane Library to identify clinical trials that investigated PD-1/PD-L1 inhibitor treatment for patients with breast cancer.Pooled overall estimates of incidence and risk ratio(RR)were calculated with a 95%confidence interval(CI),and a mirror group analysis was per-formed using eligible studies.Results:This meta-analysis included 29 studies with 4639 patients who received PD-1/PD-L1 inhibitor treatment.A higher ILD incidence was observed among 2508 patients treated with PD-1 inhibitors than among 2131 patients treated with PD-L1 inhibitors(0.05 vs.0.02).The mirror group analysis further revealed a higher ILD event risk in patients treated with PD-1 inhibitors than in those treated with PD-L1 inhibitors(RR=2.34,95%CI,1.13-4.82,P=0.02).Conclusion:Our findings suggest a greater risk of ILD with PD-1 inhibitors than with PD-L1 inhibitors.These findings are instrumental for clinicians in treatment deliberations,and the adoption of more structured diagnostic approaches and management protocols is necessary to mitigate the risk of ILD.展开更多
Disordered flexible linkers(DFLs)are the functional disordered regions in proteins,which are the sub-regions of intrinsically disordered regions(IDRs)and play important roles in connecting domains and maintaining inte...Disordered flexible linkers(DFLs)are the functional disordered regions in proteins,which are the sub-regions of intrinsically disordered regions(IDRs)and play important roles in connecting domains and maintaining inter-domain interactions.Trained with the limited available DFLs,the existing DFL predictors based on the machine learning techniques tend to predict the ordered residues as DFLs,leading to a high false positive rate(FPR)and low prediction accuracy.Previous studies have shown that DFLs are extremely flexible disordered regions,which are usually predicted as disordered residues with high confidence[P(D)>0.9]by an IDR predictor.Therefore,transferring an IDR predictor to an accurate DFL predictor is of great significance for understanding the functions of IDRs.In this study,we proposed a new predictor called TransDFL for identifying DFLs by transferring the RFPR-IDP predictor for IDR identification to the DFL prediction.The RFPR-IDP was pre-trained with IDR sequences to learn the general features between IDRs and DFLs,which is helpful to reduce the false positives in the ordered regions.RFPR-IDP was fine-tuned with the DFL sequences to capture the specific features of DFLs so as to be transferred into the TransDFL.Experimental results of two application scenarios(prediction of DFLs only in IDRs or prediction of DFLs in entire proteins)showed that TransDFL consistently outperformed other existing DFL predictors with higher accuracy.展开更多
In examining the historical changes in cognitive psychology from 1895 to 1949, it is necessary to transform cognitive psychology into cognitive practice. In the late Qing and early Republic era(1895-1919), cognitive p...In examining the historical changes in cognitive psychology from 1895 to 1949, it is necessary to transform cognitive psychology into cognitive practice. In the late Qing and early Republic era(1895-1919), cognitive practice mainly appeared as the cognition of the sick at heart. Against the background of the late Qing importation of Western learning aimed at securing national salvation, the intellectual class, represented by Tan Sitong,hastily dressed the wound to the traditional Chinese learning of Heaven and man inflicted by late nineteenth century scientific knowledge from Europe and America. They regarded cognition as the understanding gained in the practice of self-cultivation, as affording man a spiritual resting place between Heaven and Earth. By the time of the Republic of China(1920-1949), the main form of cognitive practice had become ghostly cognition.Under the banner of saving the country by means of science, higher education researchers,represented by Lu Zhiwei, explored cognition with the help of such intermediaries as physiological mechanisms and language structure. Men could easily become ghosts trapped in intermediaries when they plunged into the conceptual world in search of truth,as their cognitive practice evolved into the conceptual grasp of ghosts. This ghostly cognition continued into later information processing psychology and was disseminated among the mass of the public. A deeper level of the cognition of the sick at heart remains for future study, on the lengthy road home.展开更多
A sufficient condition is obtained for the minimality of the complex exponential system E（A, M） = {z^le^λnz： l = 0, 1,,.., mn - 1; n = 1, 2,...} in the Banaeh space La^p consisting of all functions f such that f^...A sufficient condition is obtained for the minimality of the complex exponential system E（A, M） = {z^le^λnz： l = 0, 1,,.., mn - 1; n = 1, 2,...} in the Banaeh space La^p consisting of all functions f such that f^-a ∈ LP（N）. Moreover, if the incompleteness holds, each function in the closure of the linear span of exponential system E（A, M） can be extended to an analytic function represented by a Taylor-Dirichlet series.展开更多
To the Editor:Gastric cancer(GC)poses a great threat to human health worldwide.N6-methyladenosine(m6A)RNA methylation,the most abundant post-transcriptional RNA modification,plays a crucial role in RNA splicing,export...To the Editor:Gastric cancer(GC)poses a great threat to human health worldwide.N6-methyladenosine(m6A)RNA methylation,the most abundant post-transcriptional RNA modification,plays a crucial role in RNA splicing,export,processing,translation,and decay.ii The tumor microenvironment(TME),an aggregation of tumor cells and surrounding tumor-related non-tumor cells,innately modulates tumor progression,21However,the prognostic value of m6A regulator-related genes and their relationship with the TME have not been largely explored in GC.The aim of our study was to screen prognostic genes related to m6A modification in GC patients in The Cancer Genome Atlas(TCGA)database,establish an m6A regulatorassociated signature for predicting clinical outcome,and validate the performance in TCGA and Gene Expression Omnibus(GEO)cohorts.The relationship between m6A and immune infiltration was also assessed in GC.With the underlyingmechanismuncovered,m6A-relatedgenescould become predictive biomarkers for GC and provide deeper insights into the TME and immunotherapy.展开更多
基金funded by the Research on Intelligent Mining Geological Model and Ventilation Model for Extremely Thin Coal Seam in Heilongjiang Province,China(2021ZXJ02A03)the Demonstration of Intelligent Mining for Comprehensive Mining Face in Extremely Thin Coal Seam in Heilongjiang Province,China(2021ZXJ02A04)the Natural Science Foundation of Heilongjiang Province,China(LH2024E112).
文摘Coal dust explosions are severe safety accidents in coal mine production,posing significant threats to life and property.Predicting the maximum explosion pressure(Pm)of coal dust using deep learning models can effectively assess potential risks and provide a scientific basis for preventing coal dust explosions.In this study,a 20-L explosion sphere apparatus was used to test the maximum explosion pressure of coal dust under seven different particle sizes and ten mass concentrations(Cdust),resulting in a dataset of 70 experimental groups.Through Spearman correlation analysis and random forest feature selection methods,particle size(D_(10),D_(20),D_(50))and mass concentration(Cdust)were identified as critical feature parameters from the ten initial parameters of the coal dust samples.Based on this,a hybrid Long Short-Term Memory(LSTM)network model incorporating a Multi-Head Attention Mechanism and the Sparrow Search Algorithm(SSA)was proposed to predict the maximum explosion pressure of coal dust.The results demonstrate that the SSA-LSTM-Multi-Head Attention model excels in predicting the maximum explosion pressure of coal dust.The four evaluation metrics indicate that the model achieved a coefficient of determination(R^(2)),root mean square error(RMSE),mean absolute percentage error(MAPE),and mean absolute error(MAE)of 0.9841,0.0030,0.0074,and 0.0049,respectively,in the training set.In the testing set,these values were 0.9743,0.0087,0.0108,and 0.0069,respectively.Compared to artificial neural networks(ANN),random forest(RF),support vector machines(SVM),particle swarm optimized-SVM(PSO-SVM)neural networks,and the traditional single-model LSTM,the SSA-LSTM-Multi-Head Attention model demonstrated superior generalization capability and prediction accuracy.The findings of this study not only advance the application of deep learning in coal dust explosion prediction but also provide robust technical support for the prevention and risk assessment of coal dust explosions.
文摘Background:Bordetella pertussis,the causative agent of whooping cough,is a significant contributor to recurrent persistent cough across all age groups,including vaccinated individuals.This seroepidemiological study aims to address the gap in understanding pertussis incidence by investigating its occurrence in individuals with persistent cough and describing the characteristics of affected patients admitted to clinical centers in Jahrom,Southwest Iran.Methods:This cross-sectional study enrolled 110 patients with a cough persisting for at least 2 weeks,admitted to clinical centers in Jahrom,Iran.Blood samples were collected at baseline and on day 21 of follow-up.Serum samples were analyzed for anti-pertussis toxin immunoglobulin G(anti-PT-IgG)levels using an enzyme-linked immunosorbent assay.Demographic factors,including age,gender,occupation,area of residence,and family size,were also evaluated.Results:Among the 110 participants,77(70%)were female,and seven patients(6.4%)tested seropositive for anti-PT-IgG.No significant associations were observed between pertussis incidence and the analyzed variables,including age,gender,occupation,area of residence(urban vs.rural),and family size(p>0.05).These findings underscore the importance of enhancing vaccination coverage to reduce the prevalence of B.pertussis in the community.Conclusion:This study highlights the occurrence of pertussis in individuals presenting solely with a persistent cough,absent of classic symptoms.The findings emphasize the need for healthcare providers to conduct detailed assessments and utilize rapid diagnostic methods for timely detection.This is particularly crucial in regions with high vaccination rates but limited awareness of pertussis recurrence.
基金supported by the National Natural Science Foundation of China(Grants No.42001025 and 42001014)the Belt and Road Special Foundation of the State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering(Grant No.2021491211)the Natural Science Foundation of Ningbo Municipality(Grant No.2023J133).
文摘Suzhou City,located in the Yangtze River Delta in China,is prone to flooding due to a complex combination of natural factors,including its monsoon climate,low elevation,and tidally influenced position,as well as intensive human activities.The Large Encirclement Flood Control Project(LEFCP)was launched to cope with serious floods in the urban area.This project changed the spatiotemporal pattern of flood processes and caused spatial diversion of floods from the urban area to the outskirts of the city.Therefore,this study developed a distributed flood simulation model in order to understand this transition of flood processes.The results revealed that the LEFCP effectively protected the urban areas from floods,but the present scheduling schemes resulted in the spatial diversion of floods to the outskirts of the city.With rainstorm frequencies of 10.0%to 0.5%,the water level differences between two representative water level stations(Miduqiao(MDQ)and Fengqiao(FQ))located inside and outside the LEFCP area,ranged from 0.75 m to 0.24 m and from 1.80 m to 1.58 m,respectively.In addition,the flood safety margin at MDQ and the duration with the water level exceeding the warning water level at FQ ranged from 0.95 m to 0.43 m and from 4 h to 22 h,respectively.Rational scheduling schemes for the hydraulic facilities of the LEFCP in extreme precipitation cases were developed ac-cording to food simulations under seven scheduling scenarios.This helps to regulate the spatial flood diversion caused by the LEFCP during extreme precipitation.
文摘While the development of particular video segmentation algorithms has attracted considerable research interest, relatively little effort has been devoted to provide a methodology for evaluating their performance. In this paper, we propose a methodology to objectively evaluate video segmentation algorithm with ground-truth, which is based on computing the deviation of segmentation results from the reference segmentation. Four different metrics based on classification pixels, edges, relative foreground area and relative position respectively are combined to address the spatial accuracy. Temporal coherency is evaluated by utilizing the difference of spatial accuracy between successive frames. The experimental results show the feasibility of our approach. Moreover, it is computationally more efficient than previous methods. It can be applied to provide an offline ranking among different segmentation algorithms and to optimally set the parameters for a given algorithm.
文摘At present, unified and effective treatment for hypertension with insomnia is still lacking, traditional Chinese medicine (TCM) nursing technology can improve insomnia symptoms, reduce blood pressure, alleviate fatigue, improve anxiety, depression, improve the quality of life for patients with hypertension and insomnia. There is not only the application of the single TCM nursing technology, such as acupoint massage, acupoint application, ear acupoint pressure beans and so on, but also the application of two or a variety of TCM nursing techniques in hypertension with insomnia. In this article, the results of TCM nursing technology on hypertension with insomnia in recent years are reviewed in order to provide reference for the treatment of hypertensive with insomnia.
文摘Applying the air impact molding method to mold the complicated pattern with wider opening surface and deeper concave, there always exist vaulted phenomenon and lower compactibility of sand mold over the entrance and the concave regions. Using the air-stream and synchro-formed clamp plate impact molding, however, this problem will be preferably solved. In this paper, the compact mechanism of the new molding method and the effect of some configuration factors, such as the area flowed by compressed air and the highness of the protruding block displacement around the diffluent clamp plate, on the compactibility of sand mold were discussed.
文摘The key to carry out ICAD technology is to establish the knowledge-based and wide rang of domains-covered product model.This paper put out a knowledge-based methodology of adaptive modeling.It is under the Ontology mind,using the Object-Oriented technology and being a knowledge-based model framework.It involves the diverse domains in product design and realizes the multi-domain modeling,embedding the relative information including standards,regulars and expert experience.To test the feasibility of the methodology,the research bonds of the automotive diaphragm spring clutch design and an adaptive clutch design model is established,using the knowledge-based modeling language-AML.
基金Supported by National Natural Science Foundation of China (60274013, 60474002)Science Research Foundation of Shandong University at Weihai (XZ2005001)
文摘This paper discusses the single-machine rescheduling problem with efficiency and stability as criteria, where more than one disruption arises in large-scale dynamic circumstances. Partial rescheduling (PR) strategy is adopted after each disruption and a rolling mechanism is driven by events in response to disruptions. Two kinds of objective functions are designed respectively for PR sub-problem involving in the interim and the terminal of unfinished jobs. The analytical result demonstrates that each local objective is consistent with the global one. Extensive computational experiment was performed and the computational results show that the rolling PR strategy with dual objectives can greatly improve schedule stability with little sacrifice in efficiency and provide a reasonable trade-off between solution quality and computational efforts.
基金the Key Discipline of Zhejang Province in Public Health and Preventative Medicine(First Class,Category A)at the Hangzhou Medical College,China.
文摘Background Educational inequalities in suicide have become increasingly prominent over the past decade.Elucidating modifiable risk factors that serve as intermediaries in the impact of low educational attainment on suicide has the potential to reduce health disparities.Aims To examine the risk factors that mediate the relationship between educational attainment and suicide attempts and quantify their contributions to the mediation effect.Methods We conducted a two-sample Mendelian randomisation(MR)analysis to estimate the causal effect of educational attainment on suicide attempts,utilising genome-wide association study summary statistics from the Integrative Psychiatric Research(iPSYCH;6024 cases and 44240 controls)and FinnGen(8978 cases and 368299 controls).We systematically evaluated 42 putative mediators within the causal pathway connecting reduced educational attainment to suicide attempts and employed two-step and multivariable MR to quantify the proportion of the mediated effect.Results In the combined analysis of iPSYCH and FinnGen,each standard deviation(SD)decrease in genetically predicted educational attainment(equating to 3.4 years of education)was associated with a 105%higher risk of suicide attempts(odds ratio(OR):2.05;95%confidence interval(Cl):1.81 to 2.31).0f the 42 risk factors analysed,the two-step MR identified five factors that mediated the association between educational attainment and suicide attempts.The respective proportions of mediation were 47%(95%Cl:29%to 66%)for smoking behaviour,36%(95%Cl:0%to 84%)for chronic pain,49%(95%Cl:36%to 61%)for depression,35%(95%Cl:12%to 59%)for anxiety and 26%(95%Cl:18%to 34%)for insomnia.Multivariable MR implicated these five mediators collectively,accounting for 68%(95%Cl:40%to 96%)of the total effect.Conclusions This study identified smoking,chronic pain and mental disorders as primary intervention targets for attenuating suicide risk attributable to lower educational levels in the European population.
基金supported by the National Natural Science Foundation of China(82402203,82202078)the Major Project of the National Social Science Foundation of China(23&ZD203)+3 种基金the Open Project of the Key Laboratory of Forensic Genetics of the Ministry of Public Security(2022FGKFKT05,2024FGKFKT02)the Center for Archaeological Science of Sichuan University(23SASA01)the 1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC20002)the Sichuan Science and Technology Program(2024NSFSC1518)。
文摘Genomic sources from China are underrepresented in the population-specific reference database.We performed whole-genome sequencing or genome-wide genotyping on 1,207 individuals from four linguistically diverse groups(1,081 Sinitic,56 Mongolic,40 Turkic,and 30Tibeto-Burman people)living in North China included in the 10K Chinese People Genomic Diversity Project(10K_CPGDP)to characterize the genetic architecture and adaptative history of ethnic groups in the Silk Road Region of China.We observed a population split between Northwest Chinese minorities(NWCMs)and Han Chinese since the Upper Paleolithic and later Neolithic genetic differentiation within NWCMs.The observed population substructures among ethnically/linguistically diverse NWCMs suggested that differentiated admixture events contributed to the differences in their genomic and phenotypic diversity.We estimated that the Dongxiang,Tibetan,and Yugur people inherited more than 10%of the Western Eurasian ancestry,which is much greater than that of the Salar and Tu people(<7%),while Han neighbors showed less West Eurasian ancestry(~1%-3%).Male-biased admixture introduced Western Eurasian ancestry in the Dongxiang,Tibetan,and Yugur populations.We found that the eastern-western admixture in NWCMs occurred~800-1,100 years ago,coinciding with intensive economic and cultural exchanges during the Tang and Song dynasties.Additionally,we identified the signatures of natural selection associated with cardiovascular system diseases or lipid metabolism and developmental/neurogenetic disorders.Moreover,the EPAS1 gene showed relatively high population branch statistic values in NWCMs.The well-fitted demographical models presented the vast landscape of complex admixture processes of the Silk Road people,and the newly reported functionally important variations suggested the importance of including ethnolinguistically diverse populations in Chinese genetic studies for uncovering the genetic basis of complex traits/diseases.
基金supported by National Natural Science Foundation of China(grant No.22478317).
文摘Due to the lack of gas-solid radial mixing in conventional spouted bed(CSB),particles are prone to accumulation and the formation of flow dead zones.To address the limitations of CSBs,this study,for the first time,the combination optimization of the two strengthening internal components of multi-jets and draft tube was carried out,and two new types of internal strengthening structural spouted beds were proposed:the Integral Multi-jets Draft-tube Spout-fluidized Bed(IMDSFB),and the Integral Multi-jets Open-hole Draft-tube Spout-fluidized Bed(IMODSFB).At the same time,the hydrodynamic character-istics of IMDSFB and IMODSFB are studied by numerical simulation for the first time and compared with the draft tube spouted bed(DTSB)and CSB.Results indicate that compared to CSB,the spouting heights of the DTSB,IMDSFB,and IMODSFB were enhanced by 2.92%,14.75%,and 7.94%,respectively,and the dead zone of the DTSB,IMDSFB,and IMODSFB decreased by 14%,1%,and 5%,respectively.Compared to the CSB and DTSB,the addition of novel internal components notably improved the radial velocities of both gas and particles,as well as the gas-solid slip velocity,while reducing flow dead zones within the bed.Furthermore,the gas turbulence kinetic energy in the novel spout-fluidized beds was higher,with increased fluctuations of gas velocity in the spouting region.The granular temperature in the IMDSFB and IMODSFB was higher than in the CSB and DTSB,indicating enhanced particle fluctuations within the bed.These improvements contribute to more efficient gas-solid phase interactions,thereby enhancing the overall performance of the spouted bed.
基金supported by the Zhejiang Provincial Natural Science Foundation of China(No.LY18A010024)National Natural Science Foundation of China(No.12075208).
文摘In this paper,we show by Hilbert Uniqueness Method that the boundary value problem of fifth-order KdV equation{y_(t)-y_(5x)=0,(x,t)∈(0,2π)×(0,T),y(t,2π)-y(t,0)=h_(0)(t),y_(x)(t,2π)-y_(x)(t,0)=h_(1)(t),y_(2x)(t,2π)-y_(2x)(t,0)=h_(2)(t),y_(3x)(t,2π)-y_(3x)(t,0)=h_(3)(t),y_(4x)(t,2π)-y_(4x)(t,0)=h_(4)(t),(with boundary data as control inputs)is exact controllability.
基金supported by the National Key Research and Devel.opment Program of China(Grant No.2017YFB0403000)the National Natural Science Foundation of China(Grants No.61774002 and 11634002).
文摘In this study,the physical properties of F ion-implanted GaN were thoroughly studied,and the related electric-field modulation mechanisms in ion-implanted edge termination were revealed.Transmission electron microscopy re.sults indicate that the ion-implanted region maintains a single-crystal structure even with the implantation of high-energy F ions,indicating that the high resistivity of the edge termination region is not induced by amorphization.Alternately,ion implantation-induced deep levels could compensate the electrons and lead to a highly resistive layer In addition to the bulk ffect,the direct bombardment of high-energy F ions resulted in a rough and nitrogen-deficient surface,which was confirmed via atomic force microscopy(AFM)and X-ray photoelectron spectroscopy,The implanted surface with a large density of nitrogen vacancies can accommodate electrons,and it is more conductive than the bulk in the implanted region,which is validated via spreading resistance profiling and conductive AFM measurements.Under reverse bias,the implanted surface can spread the potential in the lateral direction,whereas the acceptor traps capture electrons acting as space charges,shifting the peak electric field into the bulk region in the vertical direction.As a result,the Schottky barrier diode terminated with high-energy F ion-implanted regions exhibits a breakdown voltage of over 1.2 kv.
基金funded by Basic Public Welfare Plan of Zhejiang Province(LGF20H060008)Ningbo Science and technology Service Project(2020F029).
文摘Parpose:The study aims to compare the efficacy and safety of a new minimally invasive osteosynthesis technique with those of conventional open surgery for transverse patellar fractures.Methods:It was a retrospective study.Adult patients with closed transverse patellar fracture were included,and with open comminuted patellar fracture were excluded.These patients were divided into minimally invasive osteosynthesis technique(MIOT)group and open reduction and internal fixation(ORIF)group.Surgical time,frequency of intraoperative fluoroscopy,visual analogue scale score,flexion,extension,Lysholm knee score,infection,malreduction,implant migration and implant irritation in two groups were recorded and compared.Statistical analysis was performed by the SPsS software package(version 19).A p<0.05 indicated statistical significance.Results:A total of 55 patients with transverse patellar fractures enrolled in this study,the minimally invasive technique was performed in 27 cases,and open reduction was performed in 28 cases.The surgical time in the ORIF group was shorter than that in the MIOT group(p=0.033).The visual analogue scale scores in the MIOT group were significantly lower than those in the ORIF group only in the first month after surgery(p=0.015).Flexion was restored faster in the MIOT group than that in the ORIF group at one month(p=0.001)and three months(p=0.015).Extension was recovered faster in the MIOT group than that in the ORIF group at one month(p=0.031)and three months(p=0.023).The recorded Lysholm knee scores in the MIOT group were always greater than those in the ORIF group.Complications,such as infection,malreduction,implant migration,and implant irritation,occurred more frequently in the ORIF group.Conclusion:Compared with the ORIF group,the MIOT group reduced postoperative pain and had less complications and better exercise rehabilitation.Although it requires a long operation time,MIOT may be a wise choice for transverse patellar fractures.
文摘Background:Programmed cell death 1(PD-1)and programmed cell death ligand 1(PD-L1)inhibitors have become integral elements within the current landscape of breast cancer treatment modalities;however,they are associ-ated with interstitial lung disease(ILD),which is rare but potentially fatal.Notably,only a few studies have compared the difference in ILD incidence between PD-1 and PD-L1 inhibitors.Therefore,this study aimed to assess the discrepancies regarding ILD risk between the two immune checkpoint inhibitors.We also reported three cases of ILD after PD-1 inhibitor treatment.Methods:We comprehensively searched PubMed,EMBASE,and the Cochrane Library to identify clinical trials that investigated PD-1/PD-L1 inhibitor treatment for patients with breast cancer.Pooled overall estimates of incidence and risk ratio(RR)were calculated with a 95%confidence interval(CI),and a mirror group analysis was per-formed using eligible studies.Results:This meta-analysis included 29 studies with 4639 patients who received PD-1/PD-L1 inhibitor treatment.A higher ILD incidence was observed among 2508 patients treated with PD-1 inhibitors than among 2131 patients treated with PD-L1 inhibitors(0.05 vs.0.02).The mirror group analysis further revealed a higher ILD event risk in patients treated with PD-1 inhibitors than in those treated with PD-L1 inhibitors(RR=2.34,95%CI,1.13-4.82,P=0.02).Conclusion:Our findings suggest a greater risk of ILD with PD-1 inhibitors than with PD-L1 inhibitors.These findings are instrumental for clinicians in treatment deliberations,and the adoption of more structured diagnostic approaches and management protocols is necessary to mitigate the risk of ILD.
基金supported by the National Key R&D Program of China(Grant No.2018AAA0100100)the Beijing Natural Science Foundation,China(Grant No.JQ19019).
文摘Disordered flexible linkers(DFLs)are the functional disordered regions in proteins,which are the sub-regions of intrinsically disordered regions(IDRs)and play important roles in connecting domains and maintaining inter-domain interactions.Trained with the limited available DFLs,the existing DFL predictors based on the machine learning techniques tend to predict the ordered residues as DFLs,leading to a high false positive rate(FPR)and low prediction accuracy.Previous studies have shown that DFLs are extremely flexible disordered regions,which are usually predicted as disordered residues with high confidence[P(D)>0.9]by an IDR predictor.Therefore,transferring an IDR predictor to an accurate DFL predictor is of great significance for understanding the functions of IDRs.In this study,we proposed a new predictor called TransDFL for identifying DFLs by transferring the RFPR-IDP predictor for IDR identification to the DFL prediction.The RFPR-IDP was pre-trained with IDR sequences to learn the general features between IDRs and DFLs,which is helpful to reduce the false positives in the ordered regions.RFPR-IDP was fine-tuned with the DFL sequences to capture the specific features of DFLs so as to be transferred into the TransDFL.Experimental results of two application scenarios(prediction of DFLs only in IDRs or prediction of DFLs in entire proteins)showed that TransDFL consistently outperformed other existing DFL predictors with higher accuracy.
文摘In examining the historical changes in cognitive psychology from 1895 to 1949, it is necessary to transform cognitive psychology into cognitive practice. In the late Qing and early Republic era(1895-1919), cognitive practice mainly appeared as the cognition of the sick at heart. Against the background of the late Qing importation of Western learning aimed at securing national salvation, the intellectual class, represented by Tan Sitong,hastily dressed the wound to the traditional Chinese learning of Heaven and man inflicted by late nineteenth century scientific knowledge from Europe and America. They regarded cognition as the understanding gained in the practice of self-cultivation, as affording man a spiritual resting place between Heaven and Earth. By the time of the Republic of China(1920-1949), the main form of cognitive practice had become ghostly cognition.Under the banner of saving the country by means of science, higher education researchers,represented by Lu Zhiwei, explored cognition with the help of such intermediaries as physiological mechanisms and language structure. Men could easily become ghosts trapped in intermediaries when they plunged into the conceptual world in search of truth,as their cognitive practice evolved into the conceptual grasp of ghosts. This ghostly cognition continued into later information processing psychology and was disseminated among the mass of the public. A deeper level of the cognition of the sick at heart remains for future study, on the lengthy road home.
基金Supported by the National Natural Science Foundation of China (Grant No.10671022)the Research Foundation for Doctor Programme (Grant No.20060027023)
文摘A sufficient condition is obtained for the minimality of the complex exponential system E（A, M） = {z^le^λnz： l = 0, 1,,.., mn - 1; n = 1, 2,...} in the Banaeh space La^p consisting of all functions f such that f^-a ∈ LP（N）. Moreover, if the incompleteness holds, each function in the closure of the linear span of exponential system E（A, M） can be extended to an analytic function represented by a Taylor-Dirichlet series.
基金National Key Development Plan for Precision Medicine Research(No.2017YFC 0910002)。
文摘To the Editor:Gastric cancer(GC)poses a great threat to human health worldwide.N6-methyladenosine(m6A)RNA methylation,the most abundant post-transcriptional RNA modification,plays a crucial role in RNA splicing,export,processing,translation,and decay.ii The tumor microenvironment(TME),an aggregation of tumor cells and surrounding tumor-related non-tumor cells,innately modulates tumor progression,21However,the prognostic value of m6A regulator-related genes and their relationship with the TME have not been largely explored in GC.The aim of our study was to screen prognostic genes related to m6A modification in GC patients in The Cancer Genome Atlas(TCGA)database,establish an m6A regulatorassociated signature for predicting clinical outcome,and validate the performance in TCGA and Gene Expression Omnibus(GEO)cohorts.The relationship between m6A and immune infiltration was also assessed in GC.With the underlyingmechanismuncovered,m6A-relatedgenescould become predictive biomarkers for GC and provide deeper insights into the TME and immunotherapy.
基金sponsored by the National Key R&D Program of China(Grant No.2023YFA1508800)National Natural Science Foundation of China(Grant No.22301178)+4 种基金Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University(Grant No.21TQ1400210)Fundamental Research Funds for the Central Universities(Grant No.22x010201631)the Open Grant from the Pingyuan Laboratory(2023PY-OP-0102)Excellent Young Scientists Fund Program(Overseas)Natural Science Foundation of Shanghai(Grant No.21ZR1435600).
文摘A highly stereoselective nickel-catalyzed cross-electrophile coupling of readily accessible,novel,stable oxygen-based glycosyl radical precursors,specifically 1,2-glycosyl orthoesters,is developed.This approach offers an effective pathway to synthesize diverse C-vinyl glycosides,characterized by good yields,excellent stereoselectivity,mild reaction conditions,a broad substrate scope,and versatile transformations of the resulting products.
