The growth of industry and services occurred on a world scale in recent decades, is correlated to large events that propel whole nations to think of local development strategies, integrated and sustainable, based on s...The growth of industry and services occurred on a world scale in recent decades, is correlated to large events that propel whole nations to think of local development strategies, integrated and sustainable, based on structural and conjunctural changes, and brought on by human factors or natural causes in dependent of the human will, and lies in the context of innovative models of supply chain arrangements, as is the case of participatory governance network of production of oil and gas. The present study aim is identify and analyze the impacts, local and regional, due to the introduction of the production of oil and gas （originating layer known aspre-salt） in the city of Santos, Sao Paulo, Brazil. The current state of development of a software monitoring indicator is aimed at assessing the present stage and monitor the process of participatory governance in the network of production of oil and gas in Santo is presented here.展开更多
One of the clear signals of the ongoing climate change is sea level rise (SLR). Normal oceanic tides superimposed on a rising sea level and coastal flooding will affect many coastal communities. An international colla...One of the clear signals of the ongoing climate change is sea level rise (SLR). Normal oceanic tides superimposed on a rising sea level and coastal flooding will affect many coastal communities. An international collaboration among Brazil, the United Kingdom, and the United States was designed to evaluate local decision making processes and to open space for local urban managers to reflect on possible actions toward adaption to sea level rise given the historical constraints imposed by administrative and institutional structures. This project focused on the processes that shape adaptation of three coastal communities in three countries. It worked jointly with these communities in defining the problem, examining risks, and understanding the benefits and obstacles that may hinder implementation of adaptation options. The framework was co-designed by an interdisciplinary team that incorporated social and natural scientists from the three countries, including local government officials. The study addressed 1) evaluation of adaptive capacity through participant surveys and 2) physical and cost impact simulations using geospatial models of the built infrastructure and implementation of adaptation options under different hazard scenarios, including 50 and 100-year sea level rise projections and severe storms. Based on the surveys’ results, there is a clear sense of the awareness of each community of the risk of floods due to intense storms, and of the usefulness of engaging early in a process that promotes the understanding of risks, impacts, and costs. A majority of workshop participants prioritized pursuing physical and green infrastructure actions now or within coming years or decades. A positive common aspect of the three sites was the commitment shown by the stakeholders in taking part in the process and evaluating which adaptation measures could be more effective in their cities. While in the US and UK structural solutions and voluntary buyouts were prioritized for the future, Brazil prioritized structural solutions and ecosystems restoration and not voluntary buyouts. All of these are choices to increase resiliency against sea level rise that have a high benefit-cost ratio. The Adaptive Capacity Index (ACI) results illustrate barriers to adaptation action, including technical, economic and political issues that reveal inequalities in adaptive capacity among case studies.展开更多
Objective: To evaluate the incidence of acute atopic conjunctivitis in the port environment. Methods: This is a descriptive, retrospective study involving 365 worker patients from the Port of Santos and 365 patients n...Objective: To evaluate the incidence of acute atopic conjunctivitis in the port environment. Methods: This is a descriptive, retrospective study involving 365 worker patients from the Port of Santos and 365 patients not related with port activities (control group). All patients were seen at the same private hospital in the city of Santos. Data were obtained by reviewing the electronic medical records of each patient related to the admission exam (initial) and to any assistance due to ocular allergic symptoms (red eyes) between 2019 and 2021. The analyzed data included age, sex, port section (port workers), refraction, time of symptom onset, disease history, treatment, and clinical outcome. Data were statistically assessed by the Chi-square test. Results: All patents were male. The mean age (34 ± 12 vs 35 ± 11 years) and the prevalence of refractive errors were similar between groups. In contrast, ocular allergic symptoms were significantly higher in group of port workers (34%) compared with non-port workers (17%), p < 0.0001. Likewise, episodes related to ocular allergy were more frequent in port workers, p < 0.05. Workers with activities related to bulk handling were the most affected. Conclusions: The incidence of acute allergic conjunctivitis in port workers requires attention from health authorities. This may lead to prevention and a better understanding of the epidemiology of the disease.展开更多
Sewage introduction into rivers has altered the physical and chemical properties of waters and also the microbial metabolism. This study aimed to evaluate the Escherichia coli and nutrient concentrations in the Maratu...Sewage introduction into rivers has altered the physical and chemical properties of waters and also the microbial metabolism. This study aimed to evaluate the Escherichia coli and nutrient concentrations in the Maratuãand Crumaú rivers (Santos Estuary, Brazil) during two periods with distinct magnitudes of freshwater runoff, verifying possible relation of abiotic changes with the microbial metabolism. Water sampling was performed in October/2012 (dry season) and January/2013 (rainy season) at two points in the Crumaú river (upstream and downstream zone) and one in the Maratuãriver (downstream zone). The water subsamples were obtained for E. coli and nutrient analyses while the velocity of water flow, water level, temperature, salinity, and dissolved oxygen were measured in situ. The E. coli concentrations were under the detection limit in the Maratuãdownstream during the dry season reaching a maximum value (1.47 × 10<sup>4</sup> CFU/100mL) in the Crumaú upstream during the rainy season. E. coli presented strong positive correlation with nutrients (ammoniacal-N and phosphate), evidencing the sewage source in the Crumaú upstream shown by this association. In both periods, the low oxygen saturation (100 μmol·L<sup>-1</sup>) indicated considerable predominance of heterotrophic metabolism in the Crumaú upstream. The low dissolved oxygen values in Crumaú River are corroborated to show a low self-depuration capacity in the rainy period due to maintenance of high nutrient and E. coli at two points in the Crumaú river (upstream and downstream zone) and one in the Maratuãriver (downstream zone). Besides, these results evidenced that the tendency of the metabolism changed from autotrophic to heterotrophic under high river flow events at this studied estuarine sector located at Santos estuarine complex.展开更多
We investigated the impact of convexity and isoperimetric deficits on the accuracy of sectional area estimates of tree stems using traditional methods(caliper,tape,formulas based on stem diameter and circumference).In...We investigated the impact of convexity and isoperimetric deficits on the accuracy of sectional area estimates of tree stems using traditional methods(caliper,tape,formulas based on stem diameter and circumference).In two complementary experiments,the use of photographs to estimate cross-sectional areas was first validated,then the use of a caliper and diameter tape was computer-simulated.The results indicated that the photographic method offers high precision,with mean relative errors below 0.1%,minimal deviation,and no significant bias,and the traditional methods led to substantial and systematic errors,with deviations from circularity and convexity significantly increasing the errors in area estimation.展开更多
Mortality prediction in respiratory health is challenging,especially when using large-scale clinical datasets composed primarily of categorical variables.Traditional digital twin(DT)frameworks often rely on longi-tudi...Mortality prediction in respiratory health is challenging,especially when using large-scale clinical datasets composed primarily of categorical variables.Traditional digital twin(DT)frameworks often rely on longi-tudinal or sensor-based data,which are not always available in public health contexts.In this article,we propose a novel proto-DT framework for mortality prediction in respiratory health using a large-scale categorical biomedical dataset.This dataset contains 415,711 severe acute respiratory infection cases from the Brazilian Unified Health System,including both COVID-19 and non-COVID-19 patients.Four classification models—extreme gradient boosting(XGBoost),logistic regression,random forest,and a deep neural network(DNN)—are trained using cost-sensitive learning to address class imbalance.The models are evaluated using accuracy,precision,recall,F1-score,and area under the curve(AUC)related to the receiver operating characteristic(ROC).The framework supports simulated interventions by modifying selected inputs and recalculating predicted mortality.Additionally,we incorporate multiple correspondence analysis and K-means clustering to explore model sensitivity.A Python library has been developed to ensure reproducibility.All models achieve AUC-ROC values near or above 0.85.XGBoost yields the highest accuracy(0.84),while the DNN achieves the highest recall(0.81).Scenario-based simulations reveal how key clinical factors,such as intensive care unit admission and oxygen support,affect predicted outcomes.The proposed proto-DT framework demonstrates the feasibility of mortality prediction and intervention simulation using categorical data alone.This framework provides a foundation for data-driven explainable DTs in public health,even in the absence of time-series data.展开更多
The intricate landscape of neurodegenerative diseases complicates the search for effective therapeutic approaches.Photoreceptor degeneration,the common endpoint in various retinal diseases,including retinitis pigmento...The intricate landscape of neurodegenerative diseases complicates the search for effective therapeutic approaches.Photoreceptor degeneration,the common endpoint in various retinal diseases,including retinitis pigmentosa and age-related macular degeneration,leads to vision loss or blindness.While primary cell death is driven by genetic mutations,oxidative stress,and neuroinflammation,additional mechanisms contribute to disease progression.In retinitis pigmentosa,a multitude of genetic alterations can trigger the degeneration of photoreceptors,while other retinopathies,such as agerelated macular degeneration,are initiated by combinations of environmental factors,such as diet,smoking,and hypertension,with genetic predispositions.Nutraceutical therapies,which blend the principles of nutrition and pharmaceuticals,aim to harness the health benefits of bioactive compounds for therapeutic applications.These compounds generally possess multi-target effects.Polyphenols and flavonoids,secondary plant metabolites abundant in plant-based foods,are known for their antioxidant,neuroprotective,and anti-inflammatory properties.This review focuses on the potential of polyphenols and flavonoids as nutraceuticals to treat neurodegenerative diseases such as retinitis pigmentosa.Furthermore,the importance of developing reliable delivery methods to enhance the bioavailability and therapeutic efficacy of these compounds will be discussed.By combining nutraceuticals with other emerging therapies,such as genetic and cell-based treatments,it is possible to offer a more comprehensive approach to treating retinal degenerative diseases.These advancements could lead to a viable and accessible option,improving the quality of life for patients with retinal diseases.展开更多
The use of fresh versus frozen spermatozoa in men with nonobstructive azoospermia (NOA) undergoingin vitro fertilization (IVF)has been a debated hot topic among reproductive specialists. Each approach presents distinc...The use of fresh versus frozen spermatozoa in men with nonobstructive azoospermia (NOA) undergoingin vitro fertilization (IVF)has been a debated hot topic among reproductive specialists. Each approach presents distinct advantages and disadvantages,with fresh sperm typically showing superior sperm quality, while frozen sperm offers logistical flexibility and a reliable backup forrepeated cycles. This review summarizes the latest advancements in sperm retrieval and cryopreservation techniques, providingpractitioners with a comprehensive analysis of each option’s strengths and limitations. Comparative studies indicate that, althoughfresh sperm often has better quality metrics, cryopreservation methods such as vitrification have significantly improved postthawoutcomes, making frozen sperm a viable choice in assisted reproductive technologies (ART). The findings show comparablerates for fertilization, implantation, clinical pregnancy, and live birth between fresh and frozen microdissection testicular spermextraction (micro-TESE) sperm in many cases, although patient-specific factors such as timing, cost-effectiveness, and proceduralconvenience should guide the final decision. Ultimately, the choice of using fresh or frozen sperm should align with the individualneeds and conditions of patients. This tailored approach, supported by the latest advancements, can optimize ART outcomes andprovide personalized reproductive care.展开更多
Objective:Prostate cancer is a common malignancy in men over 50 years old,and radical prostatectomy,particularly via laparoscopic and robotic-assisted techniques,significantly impacts quality of life,especially in ter...Objective:Prostate cancer is a common malignancy in men over 50 years old,and radical prostatectomy,particularly via laparoscopic and robotic-assisted techniques,significantly impacts quality of life,especially in terms of erectile dysfunction.This systematic review and meta-analysis aimed to evaluate the preservation of erectile function following robotic-assisted and laparoscopic radical prostatectomy,with a separate analysis of randomized clinical trials and non-randomized studies.Methods:This review was carried out using randomized and non-randomized studies involving adult patients diagnosed with localized prostate cancer undergoing radical prostatectomy,according to Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines and registered in PROSPERO.Applicable literature from PubMed,Cochrane,Embase,and the Latin American and Caribbean Health Sciences Literature database was analysed.The bias in randomized clinical trials was assessed using the Cochrane Risk of Bias 2.0 tool,and observational studies were evaluated via the Newcastle-Ottawa Scale.The statistical analysis was performed using Review Manager version 5.4.Results:Our analysis included 13 studies involving 6281 patients.Comparative meta-analysis of non-randomized studies demonstrated that robotic techniques were significantly more effective in preserving erectile function at 3 months(risk difference[RD]0.05,95%confidence interval[CI]0.00-0.11;p=0.040),6 months(RD 0.10,95%CI 0.03-0.17;p=0.006),and 12 months postoperatively(RD 0.06,95%CI 0.02-0.10;p=0.002).Conclusion:Robotic-assisted surgery showed greater preservation of erectile function 3 months,6 months,and 12 months after radical prostatectomy.However,additional studies with meticulous methodological criteria are necessary for future analysis.展开更多
The international scientific literature presents still incipient results regarding the management of cancer symptom clusters by oncology nursing,especially in pediatric oncology.This is a promising field of investigat...The international scientific literature presents still incipient results regarding the management of cancer symptom clusters by oncology nursing,especially in pediatric oncology.This is a promising field of investigation for clinical nurses and researchers,and when it is subsidized by medium-range theories,they co-rroborate the diagnoses and interventions of nursing in oncology,enhancing the science of nursing care.This minireview article aims to discuss the utilizing the hospital clowns as a complementary therapy,to enhance quality of life and reduce stress and fatigue in pediatric cancer patients.Overall,the evidence presented so far pointed out that complementary therapy might help improve the quality of life of pediatric cancer patients,and that complementary therapy usage should be part of a health comprehensive care model,delivering therapeutic approaches that might enhance the mind-body during a pediatric cancer patients’life span.The results of scientific investigations by nurses,particularly those linked to the basic sciences,play a critical role in advancing personalized care in pediatric integrative oncology.展开更多
This work quantifies the thermal performance of natural composite blocks made from Yapatera diatomaceous earth reinforced with sugarcane bagasse fibres.Prismatic specimens(185×185 mm)with three thicknesses(≈76 m...This work quantifies the thermal performance of natural composite blocks made from Yapatera diatomaceous earth reinforced with sugarcane bagasse fibres.Prismatic specimens(185×185 mm)with three thicknesses(≈76 mm,100 mm,and 150 mm)and bagasse contents of 5–15%(wt.)were tested at hot-face temperatures of 100,250,and 450℃in a full-factorial 3×3×3 plan(54 tests).Thermal conductivity(k)was measured using a guarded hot-plate device aligned with ASTM D5470/E1530/C177.The measured k averaged 0.125 W/m·K(range~0.088–0.220 W/m·K)and remained stable in function up to 500℃.ANOVA showed that temperature and thickness significantly increased k(p<0.05),while fibre content had a weaker,non-monotonic effect beyond~10%.A response-surface model(RSM)provided accurate predictions(R^(2)≈0.95).For design purposes,thermal resistance was computed as R=Δx/k.A 150 mm block yielded R≈1.20 m^(2)K/W,comparable to~0.40 m of hollow ceramic brick and>1.0 m of concrete to reach a similar R.The composite therefore occupies a distinct niche:medium-performance insulation with high-temperature stability(≤500℃),low embodied energy(air-dried manufacturing,agro-waste feedstock),and competitive cost potential.These results support its use in industrial and building applications where conventional insulators are unsustainable or operate below the required temperature window.展开更多
Metal-Supported Solid Oxide Fuel Cells(MS-SOFCs)hold significant potential for driving the energy transition.These electrochemical devices represent the most advanced generation of Solid Oxide Fuel Cell(SOFCs)and can ...Metal-Supported Solid Oxide Fuel Cells(MS-SOFCs)hold significant potential for driving the energy transition.These electrochemical devices represent the most advanced generation of Solid Oxide Fuel Cell(SOFCs)and can pave the way for mass production and wider adoption than Proton Exchange Membrane Fuel Cells(PEMFCs)due to their fuel flexibility,higher power density and the absence of noble metals in the fabrication processes.This review examines the state-of-the-art of SOFCs and MS-SOFCs,presenting perspectives and research directions for these key technological devices,highlighting novel materials,techniques,architectures,devices,and degradation mechanisms to address current challenges and future opportunities.Techniques such as infiltration/impregnation,ex-solution catalyst synthesis,and the use of a pre-catalytic reformer layer are discussed as their impact on efficiency and prolonged activity.These concepts are also described and connected with well-dispersed nano particles,hindrance of coarsening,and an increased number of Triple Phase Boundaries(TPBs).This review also describes the synergistic use of reformers with MS-SOFCs to compose solutions in energy generation from readily available fuels.Lastly,the End-of-Life(EoL),recycling,and life-cycle assessments(LCAs)of the Fuel Cell Hybrid Electric Vehicles(FCHEVs)were discussed.LCAs comparing Fuel Cell Electric Vehicles(FCEVs)equipped with(PEMFCs)and FCHEVs equipped with MS-SOFCs,both powered with hydrogen(H_(2))generated by different routes were compared.This review aims to provide valuable insights into these key technological devices,emphasizing the importance of robust research and development to enhance performance and lifespan while reducing costs and environmental impact.展开更多
The plant species Gallesia integrifolia,known in Brazil as Pau D’alho or Guararema,has great relevance in ethnopharmacology and is popularly used in the treatment of various health conditions,such as flu,cough,worms,...The plant species Gallesia integrifolia,known in Brazil as Pau D’alho or Guararema,has great relevance in ethnopharmacology and is popularly used in the treatment of various health conditions,such as flu,cough,worms,ulcers and bacterial infections.Furthermore,several studies confirm its effectiveness in combating microorganisms of great clinical and economic importance,such as Aspergillus sp.,Penicillium sp.,Trichoderma viride and Candida albicans.However,there is still a lack of comprehensive phytochemical studies on this plant,which limits the understanding of its mechanisms of action and pharmacological potential.Therefore,this review was conducted through a narrative synthesis of the literature,gathering and analyzing available studies on the chemical composition and biological effects of G.integrifolia.The main findings indicate that the plant has antimicrobial activity and significant therapeutic potential,being effective against several pathogens of medical and economic relevance.Furthermore,the reviewed literature suggests that its bioactive compounds may have promising applications in the pharmaceutical and medical fields.The relevance of this study lies in expanding knowledge about the properties of G.integrifolia,highlighting its possible therapeutic applications and the need for further research to elucidate its mechanisms of action.The results reinforce the importance of more detailed phytochemical investigations to validate and expand the medicinal use of this species.展开更多
Understanding the nature of dark matter remains one of the most enigmatic and unresolved issues in astrophysics.Certain theoretical models address this by introducing a novel component to account for dark matter.In th...Understanding the nature of dark matter remains one of the most enigmatic and unresolved issues in astrophysics.Certain theoretical models address this by introducing a novel component to account for dark matter.In this study,we propose a new scalar field derived from string T-duality,where its associated density represents the density of the surrounding matter field,in the spherically symmetric and static medium.Our exploration reveals that this scalar field behaves as the baryonic fluid,characterized by a positive effective state equation,ωe>0.Furthermore,a detailed investigation demonstrates that this model satisfies all energy conditions beyond the event horizon of a central black hole.Considering the light deflection and radar echo delay suggests that in this scalar field,the dark matter grows up in the halo and surrounding regions of galaxy systems.This indicates that dark matter accumulates as an effective field outside the observable regions of galaxies.展开更多
The Hugo^(TM)robot-assisted surgery(RAS)system(Medtronic)is being successfully adopted in surgical procedures across Asia-Pacific,Latin America,and Europe.1e6 The Santo Antonio University Hospital in Porto,Portugal is...The Hugo^(TM)robot-assisted surgery(RAS)system(Medtronic)is being successfully adopted in surgical procedures across Asia-Pacific,Latin America,and Europe.1e6 The Santo Antonio University Hospital in Porto,Portugal is the first Portuguese hospital to implement the Hugo^(TM)RAS system.To date,this hospital has been very successful in adopting RAS,with 271 RAS procedures performed in the first year of robot implementation and 366 RAS procedures performed in approximately 15 months.The strategies that supported this successful implementation of the Hugo^(TM)RAS system in this hospital can serve as an example for improving and optimizing the adoption of RAS at other locations.This manuscript explores the measures taken to enable the successful adoption of the Hugo^(TM)RAS system in the Santo Antonio University Hospital,with a particular focus on the organizational,managerial,and economic aspects of the process.展开更多
Materials used in building envelopes and urban areas contribute significantly to the urban heat island(UHI).In this context,this paper presents a study utilizing infrared thermography(IRT)to assess urban streets and b...Materials used in building envelopes and urban areas contribute significantly to the urban heat island(UHI).In this context,this paper presents a study utilizing infrared thermography(IRT)to assess urban streets and building surface materials in the coastal city of Bayahibe,Dominican Republic.Measurements were conducted in situ in six urban street canyons(Sections A–F)during the warmest and coldest weather conditions.A FLIR T420 thermal camera,FLIR Tools+software,and the emissivity values of common building materials in Bayahibe were used to determine surface temperatures under sunlit and shaded conditions.The findings show that sunlit surfaces of urban elements generally exhibited higher surface temperatures compared to their shaded counterparts in both warm and cold periods.Metal surfaces displayed the most significant surface temperature differences between sunlit and shaded areas.Additionally,light-colored block walls presented lower surface temperatures than medium and dark-colored ones.This research provides insights into the urban microclimate of Bayahibe under different meteorological conditions.It supports the development of strategies to mitigate the UHI effect and enhance pedestrian thermal comfort in tropical and coastal cities by emphasizing the importance of shading elements and light-colored surfaces.The findings can inform specific interventions and policies for creating more sustainable and climate-resilient urban environments in the Caribbean region.展开更多
We provide an editorial of recent findings on early recurrence(ER)in rectal cancer(RC),focusing on the study on ER of resectable RC by Tsai et al.The study established an 8-month recurrence-free survival cut-off for d...We provide an editorial of recent findings on early recurrence(ER)in rectal cancer(RC),focusing on the study on ER of resectable RC by Tsai et al.The study established an 8-month recurrence-free survival cut-off for differentiating ER from late recurrence,with implications for postrecurrence survival and overall survival.This offers not only a valuable timeframe for enhancing surveillance strategies in patients at higher risk,especially those who have undergone neoadjuvant chemoradiotherapy(CRT),but also raises questions about its applicability across different populations.Furthermore,the article suggests that while CRT is very effective in reducing locoregional recurrence,this treatment alone may not fully address the overall risk of ER.The authors advocate for personalized risk assessment and intensive surveillance during the postoperative period to improve outcomes,particularly in the first year.Future research should focus on larger,multicenter studies and incorporate advanced diagnostic techniques with genetic and molecular biomarkers to enhance prediction and management of ER.The ultimate goal is to refine treatment and surveillance strategies to improve survival and quality of life for patients with RC.展开更多
BACKGROUND The optimal management of gallstones and common bile duct stones remains a subject of ongoing debate.The conventional two-stage treatment involves initial endoscopic retrograde cholangiopancreatography(ERCP...BACKGROUND The optimal management of gallstones and common bile duct stones remains a subject of ongoing debate.The conventional two-stage treatment involves initial endoscopic retrograde cholangiopancreatography(ERCP)to clear the bile duct,followed by laparoscopic cholecystectomy.Alternatively,the single-stage laparoendoscopic rendezvous(LERV)procedure combines ERCP and laparoscopic cholecystectomy in the same surgical session.AIM To evaluate the efficacy,safety,and logistical considerations of these two approaches,emphasizing their implications for different healthcare settings.METHODS A literature search was conducted through a PubMed search(2010-2024)using the terms“laparoendoscopic rendezvous”,“endoscopic retrograde cholangiopancreatography”,and“cholecystocholedocholithiasis”.Only English-language studies were included.RESULTS In our analysis,LERV significantly reduced the incidence of post-ERCP pancreatitis by 67%(2.4%vs 8.8%)and shortened hospital stay by a mean of up to 6 days.Stone clearance rates were comparable between LERV(97%)and the two-stage approach(96%).Although LERV was associated with a longer operative time(139.8 minutes vs 107.7 minutes),it demonstrated lower overall costs,largely due to reduced hospitalization.Rates of postoperative bleeding,cholangitis,and bile leak were low and did not differ significantly between groups.CONCLUSION The single-stage LERV approach is safe,effective,and associated with lower pancreatitis rates,shorter hospital stays,and reduced costs compared to the two-stage strategy.Its implementation,however,requires coordinated surgical-endoscopic expertise,making it most suitable for well-equipped centers and carefully selected patients.展开更多
Additive manufacturing(AM)of magnesium alloys is under intense research activity.Practical engineering applications demand the development of parts with adequate corrosion resistance for their safe use.It is imperativ...Additive manufacturing(AM)of magnesium alloys is under intense research activity.Practical engineering applications demand the development of parts with adequate corrosion resistance for their safe use.It is imperative to understand the corrosion mechanisms of AM-processed Mg alloys,their correlation with processing parameters,and microstructural aspects.The present review explores this topic.A thorough assessment of the current literature on the AM methods of Mg alloys was undertaken,focusing on the main corrosion mechanisms,and their correlation with the microstructure,process defects,post-processing operations,and alloy composition.The opportunities to enhance the knowledge in this field are discussed.展开更多
Azoospermia is the complete absence of spermatozoa in the ejaculate in two or more semen analyses after centrifugation.Nonobstructive azoospermia(NOA)represents the most severe form of male factor infertility accounti...Azoospermia is the complete absence of spermatozoa in the ejaculate in two or more semen analyses after centrifugation.Nonobstructive azoospermia(NOA)represents the most severe form of male factor infertility accounting for 10%–15%of cases and stems from an impairment to spermatogenesis.Understanding of the hypothalamic–pituitary–testicular axis has allowed NOA to be subcategorized by anatomic and/or pathophysiologic level.The etiologies of NOA,and therefore,the differential diagnoses when considering NOA as a cause of male factor infertility,can be subcategorized and condensed into several distinct classifications.Etiologies of NOA include primary hypogonadism,secondary hypogonadism,defects in androgen synthesis and/or response,defective spermatogenesis and sperm maturation,or a mixed picture thereof.This review includes up-to-date clinical,diagnostic,cellular,and histologic features pertaining to the multitude of NOA etiologies.This in turn will provide a framework by which physicians practicing infertility can augment their clinical decision-making,patient counseling,thereby improving upon the management of men with NOA.展开更多
文摘The growth of industry and services occurred on a world scale in recent decades, is correlated to large events that propel whole nations to think of local development strategies, integrated and sustainable, based on structural and conjunctural changes, and brought on by human factors or natural causes in dependent of the human will, and lies in the context of innovative models of supply chain arrangements, as is the case of participatory governance network of production of oil and gas. The present study aim is identify and analyze the impacts, local and regional, due to the introduction of the production of oil and gas （originating layer known aspre-salt） in the city of Santos, Sao Paulo, Brazil. The current state of development of a software monitoring indicator is aimed at assessing the present stage and monitor the process of participatory governance in the network of production of oil and gas in Santo is presented here.
文摘One of the clear signals of the ongoing climate change is sea level rise (SLR). Normal oceanic tides superimposed on a rising sea level and coastal flooding will affect many coastal communities. An international collaboration among Brazil, the United Kingdom, and the United States was designed to evaluate local decision making processes and to open space for local urban managers to reflect on possible actions toward adaption to sea level rise given the historical constraints imposed by administrative and institutional structures. This project focused on the processes that shape adaptation of three coastal communities in three countries. It worked jointly with these communities in defining the problem, examining risks, and understanding the benefits and obstacles that may hinder implementation of adaptation options. The framework was co-designed by an interdisciplinary team that incorporated social and natural scientists from the three countries, including local government officials. The study addressed 1) evaluation of adaptive capacity through participant surveys and 2) physical and cost impact simulations using geospatial models of the built infrastructure and implementation of adaptation options under different hazard scenarios, including 50 and 100-year sea level rise projections and severe storms. Based on the surveys’ results, there is a clear sense of the awareness of each community of the risk of floods due to intense storms, and of the usefulness of engaging early in a process that promotes the understanding of risks, impacts, and costs. A majority of workshop participants prioritized pursuing physical and green infrastructure actions now or within coming years or decades. A positive common aspect of the three sites was the commitment shown by the stakeholders in taking part in the process and evaluating which adaptation measures could be more effective in their cities. While in the US and UK structural solutions and voluntary buyouts were prioritized for the future, Brazil prioritized structural solutions and ecosystems restoration and not voluntary buyouts. All of these are choices to increase resiliency against sea level rise that have a high benefit-cost ratio. The Adaptive Capacity Index (ACI) results illustrate barriers to adaptation action, including technical, economic and political issues that reveal inequalities in adaptive capacity among case studies.
文摘Objective: To evaluate the incidence of acute atopic conjunctivitis in the port environment. Methods: This is a descriptive, retrospective study involving 365 worker patients from the Port of Santos and 365 patients not related with port activities (control group). All patients were seen at the same private hospital in the city of Santos. Data were obtained by reviewing the electronic medical records of each patient related to the admission exam (initial) and to any assistance due to ocular allergic symptoms (red eyes) between 2019 and 2021. The analyzed data included age, sex, port section (port workers), refraction, time of symptom onset, disease history, treatment, and clinical outcome. Data were statistically assessed by the Chi-square test. Results: All patents were male. The mean age (34 ± 12 vs 35 ± 11 years) and the prevalence of refractive errors were similar between groups. In contrast, ocular allergic symptoms were significantly higher in group of port workers (34%) compared with non-port workers (17%), p < 0.0001. Likewise, episodes related to ocular allergy were more frequent in port workers, p < 0.05. Workers with activities related to bulk handling were the most affected. Conclusions: The incidence of acute allergic conjunctivitis in port workers requires attention from health authorities. This may lead to prevention and a better understanding of the epidemiology of the disease.
文摘Sewage introduction into rivers has altered the physical and chemical properties of waters and also the microbial metabolism. This study aimed to evaluate the Escherichia coli and nutrient concentrations in the Maratuãand Crumaú rivers (Santos Estuary, Brazil) during two periods with distinct magnitudes of freshwater runoff, verifying possible relation of abiotic changes with the microbial metabolism. Water sampling was performed in October/2012 (dry season) and January/2013 (rainy season) at two points in the Crumaú river (upstream and downstream zone) and one in the Maratuãriver (downstream zone). The water subsamples were obtained for E. coli and nutrient analyses while the velocity of water flow, water level, temperature, salinity, and dissolved oxygen were measured in situ. The E. coli concentrations were under the detection limit in the Maratuãdownstream during the dry season reaching a maximum value (1.47 × 10<sup>4</sup> CFU/100mL) in the Crumaú upstream during the rainy season. E. coli presented strong positive correlation with nutrients (ammoniacal-N and phosphate), evidencing the sewage source in the Crumaú upstream shown by this association. In both periods, the low oxygen saturation (100 μmol·L<sup>-1</sup>) indicated considerable predominance of heterotrophic metabolism in the Crumaú upstream. The low dissolved oxygen values in Crumaú River are corroborated to show a low self-depuration capacity in the rainy period due to maintenance of high nutrient and E. coli at two points in the Crumaú river (upstream and downstream zone) and one in the Maratuãriver (downstream zone). Besides, these results evidenced that the tendency of the metabolism changed from autotrophic to heterotrophic under high river flow events at this studied estuarine sector located at Santos estuarine complex.
文摘We investigated the impact of convexity and isoperimetric deficits on the accuracy of sectional area estimates of tree stems using traditional methods(caliper,tape,formulas based on stem diameter and circumference).In two complementary experiments,the use of photographs to estimate cross-sectional areas was first validated,then the use of a caliper and diameter tape was computer-simulated.The results indicated that the photographic method offers high precision,with mean relative errors below 0.1%,minimal deviation,and no significant bias,and the traditional methods led to substantial and systematic errors,with deviations from circularity and convexity significantly increasing the errors in area estimation.
文摘Mortality prediction in respiratory health is challenging,especially when using large-scale clinical datasets composed primarily of categorical variables.Traditional digital twin(DT)frameworks often rely on longi-tudinal or sensor-based data,which are not always available in public health contexts.In this article,we propose a novel proto-DT framework for mortality prediction in respiratory health using a large-scale categorical biomedical dataset.This dataset contains 415,711 severe acute respiratory infection cases from the Brazilian Unified Health System,including both COVID-19 and non-COVID-19 patients.Four classification models—extreme gradient boosting(XGBoost),logistic regression,random forest,and a deep neural network(DNN)—are trained using cost-sensitive learning to address class imbalance.The models are evaluated using accuracy,precision,recall,F1-score,and area under the curve(AUC)related to the receiver operating characteristic(ROC).The framework supports simulated interventions by modifying selected inputs and recalculating predicted mortality.Additionally,we incorporate multiple correspondence analysis and K-means clustering to explore model sensitivity.A Python library has been developed to ensure reproducibility.All models achieve AUC-ROC values near or above 0.85.XGBoost yields the highest accuracy(0.84),while the DNN achieves the highest recall(0.81).Scenario-based simulations reveal how key clinical factors,such as intensive care unit admission and oxygen support,affect predicted outcomes.The proposed proto-DT framework demonstrates the feasibility of mortality prediction and intervention simulation using categorical data alone.This framework provides a foundation for data-driven explainable DTs in public health,even in the absence of time-series data.
基金Fundação de AmparoàPesquisa do Estado de São Paulo(FAPESP,Brazil,#2020/11667-0)and Universidade Federal do ABC(UFABC,Brazil)were recipients of fellowships from FAPESP:THLV(#2021/11969-9 and#2024/00828-3),GBS(#2021/14227-3),and GMB(#2024/10858-7)+1 种基金recipients of fellowships from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior(CAPES,Brazil):MIM(Finance Code 001,#88887.597402/2021-00)recipients of fellowships from Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq,Brazil.):GKD(#145164/2024-1),and DRA(#308819/2022-5).
文摘The intricate landscape of neurodegenerative diseases complicates the search for effective therapeutic approaches.Photoreceptor degeneration,the common endpoint in various retinal diseases,including retinitis pigmentosa and age-related macular degeneration,leads to vision loss or blindness.While primary cell death is driven by genetic mutations,oxidative stress,and neuroinflammation,additional mechanisms contribute to disease progression.In retinitis pigmentosa,a multitude of genetic alterations can trigger the degeneration of photoreceptors,while other retinopathies,such as agerelated macular degeneration,are initiated by combinations of environmental factors,such as diet,smoking,and hypertension,with genetic predispositions.Nutraceutical therapies,which blend the principles of nutrition and pharmaceuticals,aim to harness the health benefits of bioactive compounds for therapeutic applications.These compounds generally possess multi-target effects.Polyphenols and flavonoids,secondary plant metabolites abundant in plant-based foods,are known for their antioxidant,neuroprotective,and anti-inflammatory properties.This review focuses on the potential of polyphenols and flavonoids as nutraceuticals to treat neurodegenerative diseases such as retinitis pigmentosa.Furthermore,the importance of developing reliable delivery methods to enhance the bioavailability and therapeutic efficacy of these compounds will be discussed.By combining nutraceuticals with other emerging therapies,such as genetic and cell-based treatments,it is possible to offer a more comprehensive approach to treating retinal degenerative diseases.These advancements could lead to a viable and accessible option,improving the quality of life for patients with retinal diseases.
文摘The use of fresh versus frozen spermatozoa in men with nonobstructive azoospermia (NOA) undergoingin vitro fertilization (IVF)has been a debated hot topic among reproductive specialists. Each approach presents distinct advantages and disadvantages,with fresh sperm typically showing superior sperm quality, while frozen sperm offers logistical flexibility and a reliable backup forrepeated cycles. This review summarizes the latest advancements in sperm retrieval and cryopreservation techniques, providingpractitioners with a comprehensive analysis of each option’s strengths and limitations. Comparative studies indicate that, althoughfresh sperm often has better quality metrics, cryopreservation methods such as vitrification have significantly improved postthawoutcomes, making frozen sperm a viable choice in assisted reproductive technologies (ART). The findings show comparablerates for fertilization, implantation, clinical pregnancy, and live birth between fresh and frozen microdissection testicular spermextraction (micro-TESE) sperm in many cases, although patient-specific factors such as timing, cost-effectiveness, and proceduralconvenience should guide the final decision. Ultimately, the choice of using fresh or frozen sperm should align with the individualneeds and conditions of patients. This tailored approach, supported by the latest advancements, can optimize ART outcomes andprovide personalized reproductive care.
文摘Objective:Prostate cancer is a common malignancy in men over 50 years old,and radical prostatectomy,particularly via laparoscopic and robotic-assisted techniques,significantly impacts quality of life,especially in terms of erectile dysfunction.This systematic review and meta-analysis aimed to evaluate the preservation of erectile function following robotic-assisted and laparoscopic radical prostatectomy,with a separate analysis of randomized clinical trials and non-randomized studies.Methods:This review was carried out using randomized and non-randomized studies involving adult patients diagnosed with localized prostate cancer undergoing radical prostatectomy,according to Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines and registered in PROSPERO.Applicable literature from PubMed,Cochrane,Embase,and the Latin American and Caribbean Health Sciences Literature database was analysed.The bias in randomized clinical trials was assessed using the Cochrane Risk of Bias 2.0 tool,and observational studies were evaluated via the Newcastle-Ottawa Scale.The statistical analysis was performed using Review Manager version 5.4.Results:Our analysis included 13 studies involving 6281 patients.Comparative meta-analysis of non-randomized studies demonstrated that robotic techniques were significantly more effective in preserving erectile function at 3 months(risk difference[RD]0.05,95%confidence interval[CI]0.00-0.11;p=0.040),6 months(RD 0.10,95%CI 0.03-0.17;p=0.006),and 12 months postoperatively(RD 0.06,95%CI 0.02-0.10;p=0.002).Conclusion:Robotic-assisted surgery showed greater preservation of erectile function 3 months,6 months,and 12 months after radical prostatectomy.However,additional studies with meticulous methodological criteria are necessary for future analysis.
基金Supported by the Coordination of Improvement of Higher Education Personnel(CAPES)and National Council for Scientific and Technological Development(CNPq),No.311427/2023-5.
文摘The international scientific literature presents still incipient results regarding the management of cancer symptom clusters by oncology nursing,especially in pediatric oncology.This is a promising field of investigation for clinical nurses and researchers,and when it is subsidized by medium-range theories,they co-rroborate the diagnoses and interventions of nursing in oncology,enhancing the science of nursing care.This minireview article aims to discuss the utilizing the hospital clowns as a complementary therapy,to enhance quality of life and reduce stress and fatigue in pediatric cancer patients.Overall,the evidence presented so far pointed out that complementary therapy might help improve the quality of life of pediatric cancer patients,and that complementary therapy usage should be part of a health comprehensive care model,delivering therapeutic approaches that might enhance the mind-body during a pediatric cancer patients’life span.The results of scientific investigations by nurses,particularly those linked to the basic sciences,play a critical role in advancing personalized care in pediatric integrative oncology.
基金supported by the 2022 Teaching Research Projects Competition of Santo Toribio de Mogrovejo Catholic University(USAT),under grant number 1 under the title:“Adding Value to Sugar Cane Bagasse and Yapatera Diatomaceous Earth as a Composite Material for Thermal Insulation”.
文摘This work quantifies the thermal performance of natural composite blocks made from Yapatera diatomaceous earth reinforced with sugarcane bagasse fibres.Prismatic specimens(185×185 mm)with three thicknesses(≈76 mm,100 mm,and 150 mm)and bagasse contents of 5–15%(wt.)were tested at hot-face temperatures of 100,250,and 450℃in a full-factorial 3×3×3 plan(54 tests).Thermal conductivity(k)was measured using a guarded hot-plate device aligned with ASTM D5470/E1530/C177.The measured k averaged 0.125 W/m·K(range~0.088–0.220 W/m·K)and remained stable in function up to 500℃.ANOVA showed that temperature and thickness significantly increased k(p<0.05),while fibre content had a weaker,non-monotonic effect beyond~10%.A response-surface model(RSM)provided accurate predictions(R^(2)≈0.95).For design purposes,thermal resistance was computed as R=Δx/k.A 150 mm block yielded R≈1.20 m^(2)K/W,comparable to~0.40 m of hollow ceramic brick and>1.0 m of concrete to reach a similar R.The composite therefore occupies a distinct niche:medium-performance insulation with high-temperature stability(≤500℃),low embodied energy(air-dried manufacturing,agro-waste feedstock),and competitive cost potential.These results support its use in industrial and building applications where conventional insulators are unsustainable or operate below the required temperature window.
基金the Fundacao de Amparo à Pesquisa do Estado de Sao Paulo(FAPESP,2022/02235-4,2017/11958-1,2017/11986-5,2014/02163-7)Fundacao de Apoio da UFMG(FUNDEP,27192-36,01-P-38465/2023)Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq,405675/2022-4,56405643/2022-5,302180/2022-2,306870/2021-5)。
文摘Metal-Supported Solid Oxide Fuel Cells(MS-SOFCs)hold significant potential for driving the energy transition.These electrochemical devices represent the most advanced generation of Solid Oxide Fuel Cell(SOFCs)and can pave the way for mass production and wider adoption than Proton Exchange Membrane Fuel Cells(PEMFCs)due to their fuel flexibility,higher power density and the absence of noble metals in the fabrication processes.This review examines the state-of-the-art of SOFCs and MS-SOFCs,presenting perspectives and research directions for these key technological devices,highlighting novel materials,techniques,architectures,devices,and degradation mechanisms to address current challenges and future opportunities.Techniques such as infiltration/impregnation,ex-solution catalyst synthesis,and the use of a pre-catalytic reformer layer are discussed as their impact on efficiency and prolonged activity.These concepts are also described and connected with well-dispersed nano particles,hindrance of coarsening,and an increased number of Triple Phase Boundaries(TPBs).This review also describes the synergistic use of reformers with MS-SOFCs to compose solutions in energy generation from readily available fuels.Lastly,the End-of-Life(EoL),recycling,and life-cycle assessments(LCAs)of the Fuel Cell Hybrid Electric Vehicles(FCHEVs)were discussed.LCAs comparing Fuel Cell Electric Vehicles(FCEVs)equipped with(PEMFCs)and FCHEVs equipped with MS-SOFCs,both powered with hydrogen(H_(2))generated by different routes were compared.This review aims to provide valuable insights into these key technological devices,emphasizing the importance of robust research and development to enhance performance and lifespan while reducing costs and environmental impact.
文摘The plant species Gallesia integrifolia,known in Brazil as Pau D’alho or Guararema,has great relevance in ethnopharmacology and is popularly used in the treatment of various health conditions,such as flu,cough,worms,ulcers and bacterial infections.Furthermore,several studies confirm its effectiveness in combating microorganisms of great clinical and economic importance,such as Aspergillus sp.,Penicillium sp.,Trichoderma viride and Candida albicans.However,there is still a lack of comprehensive phytochemical studies on this plant,which limits the understanding of its mechanisms of action and pharmacological potential.Therefore,this review was conducted through a narrative synthesis of the literature,gathering and analyzing available studies on the chemical composition and biological effects of G.integrifolia.The main findings indicate that the plant has antimicrobial activity and significant therapeutic potential,being effective against several pathogens of medical and economic relevance.Furthermore,the reviewed literature suggests that its bioactive compounds may have promising applications in the pharmaceutical and medical fields.The relevance of this study lies in expanding knowledge about the properties of G.integrifolia,highlighting its possible therapeutic applications and the need for further research to elucidate its mechanisms of action.The results reinforce the importance of more detailed phytochemical investigations to validate and expand the medicinal use of this species.
文摘Understanding the nature of dark matter remains one of the most enigmatic and unresolved issues in astrophysics.Certain theoretical models address this by introducing a novel component to account for dark matter.In this study,we propose a new scalar field derived from string T-duality,where its associated density represents the density of the surrounding matter field,in the spherically symmetric and static medium.Our exploration reveals that this scalar field behaves as the baryonic fluid,characterized by a positive effective state equation,ωe>0.Furthermore,a detailed investigation demonstrates that this model satisfies all energy conditions beyond the event horizon of a central black hole.Considering the light deflection and radar echo delay suggests that in this scalar field,the dark matter grows up in the halo and surrounding regions of galaxy systems.This indicates that dark matter accumulates as an effective field outside the observable regions of galaxies.
文摘The Hugo^(TM)robot-assisted surgery(RAS)system(Medtronic)is being successfully adopted in surgical procedures across Asia-Pacific,Latin America,and Europe.1e6 The Santo Antonio University Hospital in Porto,Portugal is the first Portuguese hospital to implement the Hugo^(TM)RAS system.To date,this hospital has been very successful in adopting RAS,with 271 RAS procedures performed in the first year of robot implementation and 366 RAS procedures performed in approximately 15 months.The strategies that supported this successful implementation of the Hugo^(TM)RAS system in this hospital can serve as an example for improving and optimizing the adoption of RAS at other locations.This manuscript explores the measures taken to enable the successful adoption of the Hugo^(TM)RAS system in the Santo Antonio University Hospital,with a particular focus on the organizational,managerial,and economic aspects of the process.
基金funding by project“Use of Digital Information Technologies for Adaptation of the Effects of Climate Change in Touristic Coastal Zones of the Dominican Republic”(ADAPT_CCDR),grant number FED/2020/420-874funded by Harnessing Innovative Technologies to support Resilient Settlements on the Coastal Zones of the Caribbean(HIT RESET CARIBBEAN CARIBBEAN)implement by The University of the West Indies(The UWI),Anton de Kom University of Suriname(AdeKUS)and Caribbean Disaster and Emergency Management Agency(CDEMA),sponsored by the ACP-EU Innovation Fund,implemented by the Organization of African,Caribbean and Pacific States(OACPS)Research and Innovation Program,with the financial assistance of the European Union.
文摘Materials used in building envelopes and urban areas contribute significantly to the urban heat island(UHI).In this context,this paper presents a study utilizing infrared thermography(IRT)to assess urban streets and building surface materials in the coastal city of Bayahibe,Dominican Republic.Measurements were conducted in situ in six urban street canyons(Sections A–F)during the warmest and coldest weather conditions.A FLIR T420 thermal camera,FLIR Tools+software,and the emissivity values of common building materials in Bayahibe were used to determine surface temperatures under sunlit and shaded conditions.The findings show that sunlit surfaces of urban elements generally exhibited higher surface temperatures compared to their shaded counterparts in both warm and cold periods.Metal surfaces displayed the most significant surface temperature differences between sunlit and shaded areas.Additionally,light-colored block walls presented lower surface temperatures than medium and dark-colored ones.This research provides insights into the urban microclimate of Bayahibe under different meteorological conditions.It supports the development of strategies to mitigate the UHI effect and enhance pedestrian thermal comfort in tropical and coastal cities by emphasizing the importance of shading elements and light-colored surfaces.The findings can inform specific interventions and policies for creating more sustainable and climate-resilient urban environments in the Caribbean region.
文摘We provide an editorial of recent findings on early recurrence(ER)in rectal cancer(RC),focusing on the study on ER of resectable RC by Tsai et al.The study established an 8-month recurrence-free survival cut-off for differentiating ER from late recurrence,with implications for postrecurrence survival and overall survival.This offers not only a valuable timeframe for enhancing surveillance strategies in patients at higher risk,especially those who have undergone neoadjuvant chemoradiotherapy(CRT),but also raises questions about its applicability across different populations.Furthermore,the article suggests that while CRT is very effective in reducing locoregional recurrence,this treatment alone may not fully address the overall risk of ER.The authors advocate for personalized risk assessment and intensive surveillance during the postoperative period to improve outcomes,particularly in the first year.Future research should focus on larger,multicenter studies and incorporate advanced diagnostic techniques with genetic and molecular biomarkers to enhance prediction and management of ER.The ultimate goal is to refine treatment and surveillance strategies to improve survival and quality of life for patients with RC.
文摘BACKGROUND The optimal management of gallstones and common bile duct stones remains a subject of ongoing debate.The conventional two-stage treatment involves initial endoscopic retrograde cholangiopancreatography(ERCP)to clear the bile duct,followed by laparoscopic cholecystectomy.Alternatively,the single-stage laparoendoscopic rendezvous(LERV)procedure combines ERCP and laparoscopic cholecystectomy in the same surgical session.AIM To evaluate the efficacy,safety,and logistical considerations of these two approaches,emphasizing their implications for different healthcare settings.METHODS A literature search was conducted through a PubMed search(2010-2024)using the terms“laparoendoscopic rendezvous”,“endoscopic retrograde cholangiopancreatography”,and“cholecystocholedocholithiasis”.Only English-language studies were included.RESULTS In our analysis,LERV significantly reduced the incidence of post-ERCP pancreatitis by 67%(2.4%vs 8.8%)and shortened hospital stay by a mean of up to 6 days.Stone clearance rates were comparable between LERV(97%)and the two-stage approach(96%).Although LERV was associated with a longer operative time(139.8 minutes vs 107.7 minutes),it demonstrated lower overall costs,largely due to reduced hospitalization.Rates of postoperative bleeding,cholangitis,and bile leak were low and did not differ significantly between groups.CONCLUSION The single-stage LERV approach is safe,effective,and associated with lower pancreatitis rates,shorter hospital stays,and reduced costs compared to the two-stage strategy.Its implementation,however,requires coordinated surgical-endoscopic expertise,making it most suitable for well-equipped centers and carefully selected patients.
基金the Brazilian agency CNPq for the financial support (grant number 303604/2020-4)
文摘Additive manufacturing(AM)of magnesium alloys is under intense research activity.Practical engineering applications demand the development of parts with adequate corrosion resistance for their safe use.It is imperative to understand the corrosion mechanisms of AM-processed Mg alloys,their correlation with processing parameters,and microstructural aspects.The present review explores this topic.A thorough assessment of the current literature on the AM methods of Mg alloys was undertaken,focusing on the main corrosion mechanisms,and their correlation with the microstructure,process defects,post-processing operations,and alloy composition.The opportunities to enhance the knowledge in this field are discussed.
文摘Azoospermia is the complete absence of spermatozoa in the ejaculate in two or more semen analyses after centrifugation.Nonobstructive azoospermia(NOA)represents the most severe form of male factor infertility accounting for 10%–15%of cases and stems from an impairment to spermatogenesis.Understanding of the hypothalamic–pituitary–testicular axis has allowed NOA to be subcategorized by anatomic and/or pathophysiologic level.The etiologies of NOA,and therefore,the differential diagnoses when considering NOA as a cause of male factor infertility,can be subcategorized and condensed into several distinct classifications.Etiologies of NOA include primary hypogonadism,secondary hypogonadism,defects in androgen synthesis and/or response,defective spermatogenesis and sperm maturation,or a mixed picture thereof.This review includes up-to-date clinical,diagnostic,cellular,and histologic features pertaining to the multitude of NOA etiologies.This in turn will provide a framework by which physicians practicing infertility can augment their clinical decision-making,patient counseling,thereby improving upon the management of men with NOA.
