Background and Objectives:If the proportion of calcium intake over a whole day is related to the risk of cognitive impairment in adults is still largely unknown.This research aimed to examine the relation of dietary c...Background and Objectives:If the proportion of calcium intake over a whole day is related to the risk of cognitive impairment in adults is still largely unknown.This research aimed to examine the relation of dietary calcium intake at dinner versus breakfast with the risk of cognitive impairment by using data from the China Health and Nutrition Survey(CHNS).Methods and Study Design:A total of 2,099 participants(including 668 cognitive impairment)in the CHNS(1997–2006)were included.The participants were categorized into 5 groups in accordance with the ratio of dietary calcium intake at dinner and breakfast(Δ=dinner/breakfast).After adjustment was conducted for a series of confounding factors,Cox hazard regression modelling was performed to discuss the relation ofΔwith cognitive impairment.Dietary substitution models were used to explore the changes in cognitive impairment risk when a 5%dietary calcium intake at dinner was replaced with dietary calcium intake at breakfast.Results:Participants in the highest distribution ofΔshowed a greater susceptibility to cognitive impairment than those in the lowest quintile,with an adjusted hazard ratio of cognitive impairment of 1.38(95%CI:1.08–1.76).When maintaining total calcium intake,substituting 5%of dietary calcium intake at dinner with calcium intake at breakfast was related to an 8%decrease in the risk of cognitive impairment.Conclusions:Higher dietary calcium intake at dinner was associated with an increased risk of cognitive impairment,emphasizing the importance of appropriately distributing dietary calcium intake between breakfast and dinner.展开更多
基金National Institute for Nutrition and Health,China Center for Disease Control and Prevention,Carolina Population Center(P2C-HD-050924,T32-HD-007168)the University of North Carolina,Chapel Hill+2 种基金the National Institutes of Health(R01-HD-30880,DK-056350,R24-HD-050924,R01-HD-38700)the National Institutes of Health Fogarty International Center(D43-TW-009077,D43-TW-007709)for financial support for the CHNS data collectionfunded by the Department of Education,Heilongjiang Province[Grant number:2022-KYYWF-0810].
文摘Background and Objectives:If the proportion of calcium intake over a whole day is related to the risk of cognitive impairment in adults is still largely unknown.This research aimed to examine the relation of dietary calcium intake at dinner versus breakfast with the risk of cognitive impairment by using data from the China Health and Nutrition Survey(CHNS).Methods and Study Design:A total of 2,099 participants(including 668 cognitive impairment)in the CHNS(1997–2006)were included.The participants were categorized into 5 groups in accordance with the ratio of dietary calcium intake at dinner and breakfast(Δ=dinner/breakfast).After adjustment was conducted for a series of confounding factors,Cox hazard regression modelling was performed to discuss the relation ofΔwith cognitive impairment.Dietary substitution models were used to explore the changes in cognitive impairment risk when a 5%dietary calcium intake at dinner was replaced with dietary calcium intake at breakfast.Results:Participants in the highest distribution ofΔshowed a greater susceptibility to cognitive impairment than those in the lowest quintile,with an adjusted hazard ratio of cognitive impairment of 1.38(95%CI:1.08–1.76).When maintaining total calcium intake,substituting 5%of dietary calcium intake at dinner with calcium intake at breakfast was related to an 8%decrease in the risk of cognitive impairment.Conclusions:Higher dietary calcium intake at dinner was associated with an increased risk of cognitive impairment,emphasizing the importance of appropriately distributing dietary calcium intake between breakfast and dinner.
