AIM:To validate a visual acuity(VA)test application on touchpad in the screening of pediatric population by comparing VA results obtained with conventional tests.METHODS:A cohort of 101 patients,44 girls and 57 boys w...AIM:To validate a visual acuity(VA)test application on touchpad in the screening of pediatric population by comparing VA results obtained with conventional tests.METHODS:A cohort of 101 patients,44 girls and 57 boys with a median of 6.5 years old(3-10 years of age),presenting for eye examinations in Ophthalmology Department(Strasbourg,France)between November 1st,2018,and February 1st,2019 were enrolled.Monocular and binocular VA testing was performed on the subject using both a standard test and the touchpad application(Monoyer,"E"or,Pigassou depending of children s capacities).Patients were excluded if they were physically or mentally unable to use the touchpad.The duration of each tests,the painfulness,the comprehension,the attention of children during the test and test’s preferences were also evaluated.RESULTS:There was a good linear correlation and intra-class correlation coefficient[ICC=0.50(0.34.0.64)for binocular acuity,0.74(0.64.0.82)for right eyes and 0.525(0.37.0.66)for left eye].The standard errors of measurement were very low(0.08.0.05.0.08 for binocular VA,right eyes VA and left eyes VA,respectively).There was no difference between two tests for right eye(P=0.126);left eye(P=0.098)and binocular acuity(P=0.085).Non inferiority was proved for all binocular[-0.06(-0.09.-0.03)],right eye[-0.04(-0.07.-0.01)]and left eye[-0.06(-0.09,-0.02)]VA.The sensitivity and specificity,which correspond to the ability for our app to detect amblyopia,were 92%and 80%respectively.CONCLUSION:Our touchpad application represents an efficient and valid test of VA in children with a high specificity to detect visual impairment.展开更多
Skin moisturization can be measured in vivo by Corneometer?, giving information about the hydration level of the skin. However, this approach cannot reveal the inner changes of lipid organization involved in the integ...Skin moisturization can be measured in vivo by Corneometer?, giving information about the hydration level of the skin. However, this approach cannot reveal the inner changes of lipid organization involved in the integrity of the skin barrier. Raman microspectroscopy is an in vivo and non-invasive method that assesses the lateral organization of lipids from the stratum corneum by measuring the νasymCH2/νsymCH2 ratio. In the present study, the aim is to evaluate the moisturizing effect of two skin care products (i.e. LOTION 1: GF deep-nourishing & skin-sturdy facial emulsion;LOTION 2: placebo formula) by using the Corneometer? and Raman microspectroscopy. Results demonstrates a significant improvement of lipids organization and thus a reinforcement of the barrier function associated with an increase of the hydration level with LOTION 1 compared to LOTION 2.展开更多
文摘AIM:To validate a visual acuity(VA)test application on touchpad in the screening of pediatric population by comparing VA results obtained with conventional tests.METHODS:A cohort of 101 patients,44 girls and 57 boys with a median of 6.5 years old(3-10 years of age),presenting for eye examinations in Ophthalmology Department(Strasbourg,France)between November 1st,2018,and February 1st,2019 were enrolled.Monocular and binocular VA testing was performed on the subject using both a standard test and the touchpad application(Monoyer,"E"or,Pigassou depending of children s capacities).Patients were excluded if they were physically or mentally unable to use the touchpad.The duration of each tests,the painfulness,the comprehension,the attention of children during the test and test’s preferences were also evaluated.RESULTS:There was a good linear correlation and intra-class correlation coefficient[ICC=0.50(0.34.0.64)for binocular acuity,0.74(0.64.0.82)for right eyes and 0.525(0.37.0.66)for left eye].The standard errors of measurement were very low(0.08.0.05.0.08 for binocular VA,right eyes VA and left eyes VA,respectively).There was no difference between two tests for right eye(P=0.126);left eye(P=0.098)and binocular acuity(P=0.085).Non inferiority was proved for all binocular[-0.06(-0.09.-0.03)],right eye[-0.04(-0.07.-0.01)]and left eye[-0.06(-0.09,-0.02)]VA.The sensitivity and specificity,which correspond to the ability for our app to detect amblyopia,were 92%and 80%respectively.CONCLUSION:Our touchpad application represents an efficient and valid test of VA in children with a high specificity to detect visual impairment.
文摘Skin moisturization can be measured in vivo by Corneometer?, giving information about the hydration level of the skin. However, this approach cannot reveal the inner changes of lipid organization involved in the integrity of the skin barrier. Raman microspectroscopy is an in vivo and non-invasive method that assesses the lateral organization of lipids from the stratum corneum by measuring the νasymCH2/νsymCH2 ratio. In the present study, the aim is to evaluate the moisturizing effect of two skin care products (i.e. LOTION 1: GF deep-nourishing & skin-sturdy facial emulsion;LOTION 2: placebo formula) by using the Corneometer? and Raman microspectroscopy. Results demonstrates a significant improvement of lipids organization and thus a reinforcement of the barrier function associated with an increase of the hydration level with LOTION 1 compared to LOTION 2.
