On September 16,2022,the first imported monkeypox case was reported in the Chinese Mainland.Laboratory tests including nucleic acid detection were carried out in Chongqing Nan’an Centre for Disease Control and Preven...On September 16,2022,the first imported monkeypox case was reported in the Chinese Mainland.Laboratory tests including nucleic acid detection were carried out in Chongqing Nan’an Centre for Disease Control and Prevention and Chongqing Center for Disease Control and Prevention.After that,monkeypox virus was isolated by the Institute for Viral Disease Control and Prevention and preserved at the National Pathogen Resource Center on September 18,2022.The National Pathogen Resource Center shared the basic information of monkeypox virus strain,samples,biosafety,strain imaging,RT-PCR primers,and probes sequence timely to support the prevention and control of monkeypox epidemic and facilitate the scientific research on vaccine development,drug screening and evaluation of monkeypox virus in the future.展开更多
Zebrafish （Danio rerio）, a small tropical freshwater fish native to east India, has rapidly emerged as a popular vertebrate model organism in the last two decades. There are multiple advantages of using zebrafish in...Zebrafish （Danio rerio）, a small tropical freshwater fish native to east India, has rapidly emerged as a popular vertebrate model organism in the last two decades. There are multiple advantages of using zebrafish in biological research, including its small size, short generation time of 2-3 months, external fertilization and development, high fecundity without seasonal variation, transparent embryos, and inexpensive maintenance. The well-annotated zebrafish genome contains more than 26,000 protein-coding genes, sharing over 80% similarity with human genome, and approximately 70% of human genes have its zebrafish orthologues. Drug administration in zebrafish can be as simple as adding chemicals into fish water, and therefore it is doable to design projects with a small budget compared to mice and rats. Zebrafish is also famous for its amazing regenerative abilities, for instance, it can regenerate fins, hair cells, retina, even heart and brain. All these features make zebrafish a valuable animal model to dissect the mechanisms of biological processes and human diseases [1,2].展开更多
The recent outbreak of novel coronavirus-infected pneumonia(NCIP)in China(1)has attracted much attention domestically and internationally.As the outbreak occurred,China carried out emergency responses quickly,notified...The recent outbreak of novel coronavirus-infected pneumonia(NCIP)in China(1)has attracted much attention domestically and internationally.As the outbreak occurred,China carried out emergency responses quickly,notified the World Health Organization(WHO)in a timely manner,and shared the viral gene sequence with international communities immediately after pathogenic identification.展开更多
The Chinese tree shrew has gained prominence as a model organism due to its phylogenetic proximity to primates,offering distinct advantages over traditional rodent models in biomedical research.However,the neuroanatom...The Chinese tree shrew has gained prominence as a model organism due to its phylogenetic proximity to primates,offering distinct advantages over traditional rodent models in biomedical research.However,the neuroanatomy of this species remains insufficiently defined,limiting its utility in neurophysiological and neuropathological studies.In this study,immunofluorescence microscopy was employed to comprehensively map the distribution of three calciumbinding proteins,parvalbumin,calbindin D-28k,and calretinin,across the tree shrew cerebrum.Serial brain sections in sagittal,coronal,and horizontal planes from 12 individuals generated a dataset of 3638 cellular-resolution images.This dataset,accessible via Science Data Bank(https://doi.org/10.57760/sciencedb.23471),provides detailed region-and laminar-selective distributions of calcium-binding proteins valuable for the cyto-and chemoarchitectural characterization of the tree shrew cerebrum.This resource will not only advance our understanding of brain organization and facilitate basic and translational neuroscience research in tree shrews but also enhance comparative and evolutionary analyses across species.展开更多
Water scarcity and environment deterioration have become main constraints to sustainable economic and social development.Scientifically assessing Water Resources Carrying Capacity(WRCC)is essential for the optimal all...Water scarcity and environment deterioration have become main constraints to sustainable economic and social development.Scientifically assessing Water Resources Carrying Capacity(WRCC)is essential for the optimal allocation of regional water resources.The hilly area at the northern foot of Yanshan Mountains is a key water conservation zone and an important water source for Beijing,Tianjin and Hebei.Grasping the current status and temporal trends of water quality and WRCC in representative small watersheds within this region is crucial for supporting rational water resources allocation and environment protection efforts.This study focuses on Pingquan City,a typical watershed in northern Hebei Province.Firstly,evaluation index systems for surface water quality,groundwater quality and WRCC were estab-lished based on the Pressure-State-Response(PSR)framework.Then,comprehensive evaluations of water quality and WRCC at the sub-watershed scale were conducted using the Varying Fuzzy Pattern Recogni-tion(VFPR)model.Finally,the rationality of the evaluation results was verified,and future scenarios were projected.Results showed that:(1)The average comprehensive evaluation scores for surface water and groundwater quality in the sub-watersheds were 1.44 and 1.46,respectively,indicating that both met the national Class II water quality standard and reflected a high-quality water environment.(2)From 2010 to 2020,the region's WRCC steadily improved,with scores rising from 2.99 to 2.83 and an average of 2.90,suggesting effective water resources management in Pingquan City.(3)According to scenario-based predic-tion,WRCC may slightly decline between 2025 and 2030,reaching 2.92 and 2.94,respectively,relative to 2020 levels.Therefore,future efforts should focus on strengthening scientific management and promoting the efficient use of water resources.Proactive measures are necessary to mitigate emerging contradiction and ensure the long-term stability and sustainability of the water resources system in the region.The evalua-tion system and spatiotemporal evolution patterns proposed in this study can provide a scientific basis for refined water resource management and ecological conservation in similar hilly areas.展开更多
Safflower is an important oilseed crop that has been used in traditional Chinese medicine for thousands of years because of the clinically valuable flavonoid glycosides in its flower petals.However,the biosynthesis an...Safflower is an important oilseed crop that has been used in traditional Chinese medicine for thousands of years because of the clinically valuable flavonoid glycosides in its flower petals.However,the biosynthesis and molecular regulation of these compounds are still elusive due to the lack of a high-quality reference genome and scarce identification of key biosynthetic pathway genes in a medicinal safflower variety.Here we leveraged an integrative multi-omics strategy by combining genomic,comparative genomics,and tissue-specific transcriptome profiling with biochemical analysis to identify uridine diphosphate glycosyltransferases(UGTs)for flavonoid glycoside biosynthesis in safflower.We assembled and annotated a high-quality reference genome of a medicinal safflower variety,‘Yunhong3’.A comprehensive comparative genomic analysis indicated that an evolutionary whole-genome triplication event occurring in safflower contributed to gene amplification of the flavonoid biosynthetic pathway.By combining comparative transcriptome profiling with enzymatic reactions,we identified 11 novel UGTs that could catalyze the conversion of naringenin chalcone and phloretin to the corresponding O-glycosides.Moreover,we outlined the molecular pathway of hydroxysafflor yellow A(HSYA)biosynthesis featured by 17 newly identified UGTs with promising catalytic activity,laying the foundation for the synthetic production of HSYA.Our study reports systemic genome and gene expression information for flavonoid glycoside biosynthesis in medicinal safflower and provides insights into mechanisms regulating HSYA biosynthesis,which would facilitate the genetic improvement and synthetic bioengineering design for producing clinically valuable flavonoid glycosides in safflower.展开更多
Rapid regional population shifts and spatial polarization have heightened pressure on cultivated land—a critical resource demanding urgent attention amid ongoing urban-rural transition.This study selects Jiangsu prov...Rapid regional population shifts and spatial polarization have heightened pressure on cultivated land—a critical resource demanding urgent attention amid ongoing urban-rural transition.This study selects Jiangsu province,a national leader in both economic and agricultural development,as a case area to construct a multidimensional framework for assessing the recessive morphological characteristics of multifunctional cultivated land use.We examine temporal dynamics,spatial heterogeneity,and propose an integrated zoning strategy based on empirical analysis.The results reveal that:(1)The recessive morphology index shows a consistent upward trend,with structural breaks in 2007 and 2013,and a spatial shift from“higher in the east and lower in the west”to“higher in the south and lower in the north.”(2)Coordination among sub-dimensions of the index has steadily improved.(3)The index is expected to continue rising in the next decade,though at a slower pace.(4)To promote coordinated multidimensional land-use development,we recommend a policy framework that reinforces existing strengths,addresses weaknesses,and adapts zoning schemes to current spatial conditions.This research offers new insights into multifunctional cultivated land systems and underscores their role in enhancing human well-being,securing food supply,and supporting sustainable urban-rural integration.展开更多
Based on the regional water resources carrying capacity(WRCC)evaluation principles and evaluation index system in the National Technical Outline of Water Resources Carrying Capacity Monitoring and Early Warning(hereaf...Based on the regional water resources carrying capacity(WRCC)evaluation principles and evaluation index system in the National Technical Outline of Water Resources Carrying Capacity Monitoring and Early Warning(hereafter referred to as the Technical Outline),this paper elaborates on the collection and sorting of the basic data of water resources conditions,water resources development and utilization status,social and economic development in basins,analysis and examination of integrity,consistency,normativeness,and rationality of the basic data,and the necessity of WRCC evaluation.This paper also describes the technique of evaluating the WRCC in prefecture-level cities and city-level administrative divisions in the District of the Taihu Lake Basin,which is composed of the Taihu Lake Basin and the Southeastern River Basin.The evaluation process combines the binary index evaluation method and reduction index evaluation method.The former,recommended by the Technical Outline,uses the total water use and the amount of exploited groundwater as evaluation indices,showing stronger operability,while the latter is developed by simplifying and optimizing the comprehensive index system with greater systematicness and completeness.The mutual validation and adjustment of the results of the above-mentioned two evaluation methods indicate that the WRCC of the District of the Taihu Lake Basin is overloaded in general because some prefecture-level cities and city-level administrative divisions in the Taihu Lake Basin and the Southeastern River Basin are in a severely overloaded state.In order to explain this conclusion,this paper analyzes the causes of WRCC overloading from the aspects of basin water environment,water resources development and utilization,water resources regulation and control ability,water resources utilization efficiency,and water resources management.展开更多
Water demand increases continuously with an increasing population and economic development. As a result, the difference between water supply and demand becomes a sig- nificant issue, especially in arid regions. To fig...Water demand increases continuously with an increasing population and economic development. As a result, the difference between water supply and demand becomes a sig- nificant issue, especially in arid regions. To figure out the utilization of water resources in the arid region of northwestern China （ARNWC）, and also to provide methodologies to predict the water use in future, three models were established in this study to calculate agricultural irri- gation, industrial and domestic water use in the ARNWC from the late 1980s to 2010. Based on river discharges in the region, the supply and demand of water resources at the river basin level were analyzed. The results indicated that agricultural irrigation demand occupies more than 90% of the total water use in the ARNWC. Total water demand increased from 31.97 km3 in the late 1980s to 48.19 km3 in 2010. Most river basins in this arid region were under me- dium and high water stress. Severe-risk river basins, such as the Shiyang river basin and the eastern part of the northern piedmont of the Tianshan Mountains, were found in this region. It was revealed that the water supply became critical from April to May, which was the season of the lowest water supply as determined by comparing monthly water consumption.展开更多
This paper, based on the analysis and calculation of the groundwater resources in an arid region from 1980 to 2001, put forward the concept of ecological groundwater level threshold for either salinity control or the ...This paper, based on the analysis and calculation of the groundwater resources in an arid region from 1980 to 2001, put forward the concept of ecological groundwater level threshold for either salinity control or the determination of ecological warning. The surveys suggest that soil moisture and soil salinity are the most important environmental factors in determining the distribution and changes in vegetation. The groundwater level threshold of ecological warning can be determined by using a network of groundwater depth observation sites that monitor the environmental moisture gradient as reflected by plant physiological characteristics. According to long-term field observations within the Ejin oases, the groundwater level threshold for salinity control varied between 0.5 m and 1.5 m, and the ecological warning threshold varied between 3.5 m and 4.0 m. The quantity of groundwater re- sources （renewable water resources, ecological water resources, and exploitable water resources） in arid areas can be calculated from regional groundwater level information, without localized hydrogeological data. The concept of groundwater level threshold of ecological warning was established according to water development and water re- sources supply, and available groundwater resources were calculated. The concept not only enriches and broadens the content of groundwater studies, but also helps in predicting the prospects for water resources development.展开更多
This paper addresses the impact of climate change on the water cycle and resource changes in the Eastern Monsoon Region of China （EMRC）. It also represents a summary of the achievements made by the National Key Basi...This paper addresses the impact of climate change on the water cycle and resource changes in the Eastern Monsoon Region of China （EMRC）. It also represents a summary of the achievements made by the National Key Basic Research and Development Program （2010CB428400）, where the major research focuses are detection and attribution, extreme floods and droughts, and adaptation of water resources management. Preliminary conclusions can be summarized into four points： 1） Water cycling and water resource changes in the EMRC are rather complicated as the region is impacted by natural changes relating to the strong monsoon influence and also by climate change impacts caused by CO2 emissions due to anthropogenic forcing; 2） the rate of natural variability contributing to the influence on precipitation accounts for about 70%, and the rate from anthropogenic forcing accounts for 30% on average in the EMRC. However, with future scenarios of increasing CO2 emissions, the contribution rate from anthropogenic forcing will increase and water resources management will experience greater issues related to the climate change impact; 3） Extreme floods and droughts in the EMRC will be an increasing trend, based on IPCC-AR5 scenarios; 4） Along with rising temperatures of 1 ~C in North China, the agricultural water consumption will increase to about 4% of total water consumption. Therefore, climate change is making a significant impact and will be a risk to the EMRC, which covers almost all of the eight major river basins, such as the Yangtze River, Yellow River, Huaihe River, Haihe River, and Pearl River, and to the South-to-North Water Diversion Project （middle line）. To ensure water security, it is urgently necessary to take adaptive countermeasures and reduce the vulnerability of water resources and associated risks.展开更多
A large number of nodule minerals exist in the deep sea.Based on the factors of difficulty in shooting,high economic cost and high accuracy of resource assessment,large-scale planned commercial mining has not yet been...A large number of nodule minerals exist in the deep sea.Based on the factors of difficulty in shooting,high economic cost and high accuracy of resource assessment,large-scale planned commercial mining has not yet been conducted.Only experimental mining has been carried out in areas with high mineral density and obvious benefits after mineral resource assessment.As an efficient method for deep-sea mineral resource assessment,the deep towing system is equipped with a visual system for mineral resource analysis using collected images and videos,which has become a key component of resource assessment.Therefore,high accuracy in deep-sea mineral image segmentation is the primary goal of the segmentation algorithm.In this paper,the existing deep-sea nodule mineral image segmentation algorithms are studied in depth and divided into traditional and deep learning-based segmentation methods,and the advantages and disadvantages of each are compared and summarized.The deep learning methods show great advantages in deep-sea mineral image segmentation,and there is a great improvement in segmentation accuracy and efficiency compared with the traditional methods.Then,the mineral image dataset and segmentation evaluation metrics are listed.Finally,possible future research topics and improvement measures are discussed for the reference of other researchers.展开更多
Western China includes 12 provincial divisions (the 7 provinces of Sichuan, Guizhou, Yunnan, Shaanxi, Gansu, Qinghai and; 5 autonomous regions of Tibet, Ningxia, Xinjiang, Inner Mongolia and Guangxi; and one city of C...Western China includes 12 provincial divisions (the 7 provinces of Sichuan, Guizhou, Yunnan, Shaanxi, Gansu, Qinghai and; 5 autonomous regions of Tibet, Ningxia, Xinjiang, Inner Mongolia and Guangxi; and one city of Chongqing), which comprise 71.4% of the national land area, 28.5% of the national population and produce 17.5% of the national GDP in China. There are 17 countries that have riparian relationships with western China, most of which are water-short countries. All are listed by UN ESCAP as countries with potential water crisis. The co-operative development and coordinated management of international rivers in western China is an important step toward the implementation of the national Great Western Development program. Taking into account of the national strategy and object hierarchy, as well as the development demand of the western region, it is necessary to pursue the multi-disciplinary study of the equitable allocation, utilisation, and eco-environment protection of transboundary water resources in the region. Such efforts will undoubtedly provide scientific evidence and support for the decision-making of the environmental protection and ecological construction and management in the western regions, the enforcement of the sub-regional economic co-operation, mitigation of trans-boundary conflicts, and enhancing bio-diversity conservation.展开更多
Shannan Prefecture of Tibet is the central producing region of Tibetan chicken, and Tibetan chicken feeding has become one of the characteristic industries of animal husbandry in local agricultural and pastoral area, ...Shannan Prefecture of Tibet is the central producing region of Tibetan chicken, and Tibetan chicken feeding has become one of the characteristic industries of animal husbandry in local agricultural and pastoral area, and it is an important source of food and income for the locals. However, because of extensive feed- ing managemem, low level of intensification, blind hybrid of exotic varieties and despising selective breeding, the number of pedigree Tibetan chickens have reduced year by year and the performance of Tibetan chicken herd varied greatly, premium specificity could not be effectively utihzed. By investigating the present situation of Tibetan chicken feeding, analyzing the specificity of Tibetan chicken germplasm resources, the scientific conservation breeding was started to make full use of the advantage of keeping Tibetan chickens on the plateau.展开更多
Readability is a fundamental problem in textbooks assessment.For low resources languages(LRL),however,little investigation has been done on the readability of textbook.In this paper,we proposed a readability assessmen...Readability is a fundamental problem in textbooks assessment.For low resources languages(LRL),however,little investigation has been done on the readability of textbook.In this paper,we proposed a readability assessment method for Tibetan textbook(a low resource language).We extract features based on the information that are gotten by Tibetan segmentation and named entity recognition.Then,we calculate the correlation of different features using Pearson Correlation Coefficient and select some feature sets to design the readability formula.Fit detection,F test and T test are applied on these selected features to generate a new readability assessment formula.Experiment shows that this new formula is capable of assessing the readability of Tibetan textbooks.展开更多
This study focused on the investigation of crop germplasm resources in coastal areas of Shandong Province, including 132 villages in 82 towns of 34 counties. The survey collected local varieties and wild resources of ...This study focused on the investigation of crop germplasm resources in coastal areas of Shandong Province, including 132 villages in 82 towns of 34 counties. The survey collected local varieties and wild resources of grain crops, economic crops, vegetables and fruit trees, and a total of 848 samples were collected, belonging to 54 species of 39 genera in 15 families. In this study, the current situation and growth and decline conditions of crop germplasm resources were investigated, and their botanical classification and utilization importance were analyzed. Furthermore, the conservation, development and utilization of crop germplasrp resources in coastal areas of Shandong Province were also discussed in this paper.展开更多
Dear Editor,Te Veterans Health Administration(VHA)provides healthcare for over 9 million enrolled veterans with approximately 2.7 million of those residing in rural areas[1].Te MISSION Act of 2018 emphasizes VHA colla...Dear Editor,Te Veterans Health Administration(VHA)provides healthcare for over 9 million enrolled veterans with approximately 2.7 million of those residing in rural areas[1].Te MISSION Act of 2018 emphasizes VHA collaboration with Federally Qualifed Healthcare Centers(FQHC)to serve rural residing veterans and nearly all existing collaborations involve arrangement of payment for community-based care by VHA to FQHCs.Unfortunately,there is a paucity of descriptive clinical data on existing cross-system collaborations which may help characterize these veterans and aid understanding of conditions for which they may receive treatment across systems.Such data has implications for workforce training,development,and resource allocation[2].Te objective of this report is to describe diferent clinical profles between two mutually exclusive samples:veterans engaged in FQHC only use,and VHA-enrolled veterans engaged in dual VHA and FQHC use.展开更多
Polygonatum is a traditional and precious Chinese medicine in China,as well as a traditional medicinal and food homologous material.It has a long history of cultivation and medicinal use.It not only has the effects of...Polygonatum is a traditional and precious Chinese medicine in China,as well as a traditional medicinal and food homologous material.It has a long history of cultivation and medicinal use.It not only has the effects of boosting qi and nourishing yin,nourishing the spleen and lungs,and tonifying the kidney,but also application value in food,health products,ornamental,cosmetics,etc.There are many varieties of Polygonatum resources all over China,which are easy to be mixed.There are three species of medicinal Polygonatum recorded in the 2015 edition of Pharmacopeia of the People s Republic of China.In order to sustainably use and fully develop Polygonatum medicinal resources,we conducted textual research on relevant data and research on the distribution of Polygonatum resources,germplasm identification,genetic diversity and breeding research,so as to provide a reference for the selection and breeding of polygonatum,artificial cultivation and the development and utilization of potential Polygonatum resources and for the solution of the contradiction between supply and demand in the Polygonatum market.展开更多
This paper discusses the Project's organization system, technical system, creation of digital resources and service mode. It also summarizes achievements gained since the commencement of the Project, and also anal...This paper discusses the Project's organization system, technical system, creation of digital resources and service mode. It also summarizes achievements gained since the commencement of the Project, and also analyzes some of the more important issues during implementation stage and gives a few suggestions of the future development during the next stage of the 11thFive-Year Plan.展开更多
Talent is the inexhaustible driving force for the development of enterprises. In the development of enterprises, the importance of talent gradually highlighted. Pay great attention to human resources compensation mana...Talent is the inexhaustible driving force for the development of enterprises. In the development of enterprises, the importance of talent gradually highlighted. Pay great attention to human resources compensation management and human resources compensation management quality has become an important factor affecting the development and progress of enterprises. Enterprises need talents to promote their development. Human resource management can provide high-quality talents for enterprise and improve their competitive advantages and guide enterprises to develop efficiently and maximize economic benefits. Human resource compensation management can reasonably design salary treatment based on employees' performance, motivate employees' enthusiasm, guide employees to efficiently complete their own work under reasonable salary management and greatly improve work efficiency and quality. Although enterprises attach more importance to human resource compensation management, in the actual implementation process, there are still problems such as unreasonable compensation design, backward management system and concept, and imperfect compensation incentive mechanism, leading to the low quality of human resource compensation management. In view of the problems existing in the salary management, enterprises should take countermeasures according to the actual situation, scientifically and reasonably design the salary, improve the salary incentive mechanism, realize the common development of employees and enterprises, improve the core competitiveness of enterprises and occupy a favorable position in the fierce market competition.展开更多
基金supported by the National Science and Technology Major Project on Important Infectious Diseases Prevention and Control(2018ZX10734404)National Key R&D Program of China(2022YFC2602200)the National Science and Technology Infrastructure of China(Project No.National Pathogen Resource Center NPRC-32).
文摘On September 16,2022,the first imported monkeypox case was reported in the Chinese Mainland.Laboratory tests including nucleic acid detection were carried out in Chongqing Nan’an Centre for Disease Control and Prevention and Chongqing Center for Disease Control and Prevention.After that,monkeypox virus was isolated by the Institute for Viral Disease Control and Prevention and preserved at the National Pathogen Resource Center on September 18,2022.The National Pathogen Resource Center shared the basic information of monkeypox virus strain,samples,biosafety,strain imaging,RT-PCR primers,and probes sequence timely to support the prevention and control of monkeypox epidemic and facilitate the scientific research on vaccine development,drug screening and evaluation of monkeypox virus in the future.
文摘Zebrafish （Danio rerio）, a small tropical freshwater fish native to east India, has rapidly emerged as a popular vertebrate model organism in the last two decades. There are multiple advantages of using zebrafish in biological research, including its small size, short generation time of 2-3 months, external fertilization and development, high fecundity without seasonal variation, transparent embryos, and inexpensive maintenance. The well-annotated zebrafish genome contains more than 26,000 protein-coding genes, sharing over 80% similarity with human genome, and approximately 70% of human genes have its zebrafish orthologues. Drug administration in zebrafish can be as simple as adding chemicals into fish water, and therefore it is doable to design projects with a small budget compared to mice and rats. Zebrafish is also famous for its amazing regenerative abilities, for instance, it can regenerate fins, hair cells, retina, even heart and brain. All these features make zebrafish a valuable animal model to dissect the mechanisms of biological processes and human diseases [1,2].
基金supported by National Science and Technology Major Project on Important Infectious Diseases Prevention and Control(2018ZX10734404)National Key Research and Development Project(2020YFC0840800,2020YFC0840900).
文摘The recent outbreak of novel coronavirus-infected pneumonia(NCIP)in China(1)has attracted much attention domestically and internationally.As the outbreak occurred,China carried out emergency responses quickly,notified the World Health Organization(WHO)in a timely manner,and shared the viral gene sequence with international communities immediately after pathogenic identification.
基金supported by the Science and Technology Innovation(STI)2030-Major Projects(2022ZD0205000 to L.L.)CAS“Light of West China”Program(xbzg-zdsys-202404 to L.L.)+1 种基金Yunnan Revitalization Talent Support Program Yunling Scholar Project(to L.L.)Yunnan Fundamental Research Projects(202305AH340006,202301AS070060 to L.L.,202401AT070206 to X.C.)。
文摘The Chinese tree shrew has gained prominence as a model organism due to its phylogenetic proximity to primates,offering distinct advantages over traditional rodent models in biomedical research.However,the neuroanatomy of this species remains insufficiently defined,limiting its utility in neurophysiological and neuropathological studies.In this study,immunofluorescence microscopy was employed to comprehensively map the distribution of three calciumbinding proteins,parvalbumin,calbindin D-28k,and calretinin,across the tree shrew cerebrum.Serial brain sections in sagittal,coronal,and horizontal planes from 12 individuals generated a dataset of 3638 cellular-resolution images.This dataset,accessible via Science Data Bank(https://doi.org/10.57760/sciencedb.23471),provides detailed region-and laminar-selective distributions of calcium-binding proteins valuable for the cyto-and chemoarchitectural characterization of the tree shrew cerebrum.This resource will not only advance our understanding of brain organization and facilitate basic and translational neuroscience research in tree shrews but also enhance comparative and evolutionary analyses across species.
基金financially supported by China Geological Survey Project(No.DD20220954)Open Funding Project of the Key Laboratory of Groundwater Sciences and Engineering,Ministry of Natural Resources(No.SK202301-4)+2 种基金Science and Technology Innovation Foundation of Comprehensive Survey&Command Center for Natural Resources(No.KC20240003)Yanzhao Shanshui Science and Innovation Fund of Langfang Integrated Natural Resources Survey Center,China Geological Survey(No.YZSSJJ202401-001)Open Foundation of the Key Laboratory of Coupling Process and Effect of Natural Resources Elements(No.2022KFKTC009).
文摘Water scarcity and environment deterioration have become main constraints to sustainable economic and social development.Scientifically assessing Water Resources Carrying Capacity(WRCC)is essential for the optimal allocation of regional water resources.The hilly area at the northern foot of Yanshan Mountains is a key water conservation zone and an important water source for Beijing,Tianjin and Hebei.Grasping the current status and temporal trends of water quality and WRCC in representative small watersheds within this region is crucial for supporting rational water resources allocation and environment protection efforts.This study focuses on Pingquan City,a typical watershed in northern Hebei Province.Firstly,evaluation index systems for surface water quality,groundwater quality and WRCC were estab-lished based on the Pressure-State-Response(PSR)framework.Then,comprehensive evaluations of water quality and WRCC at the sub-watershed scale were conducted using the Varying Fuzzy Pattern Recogni-tion(VFPR)model.Finally,the rationality of the evaluation results was verified,and future scenarios were projected.Results showed that:(1)The average comprehensive evaluation scores for surface water and groundwater quality in the sub-watersheds were 1.44 and 1.46,respectively,indicating that both met the national Class II water quality standard and reflected a high-quality water environment.(2)From 2010 to 2020,the region's WRCC steadily improved,with scores rising from 2.99 to 2.83 and an average of 2.90,suggesting effective water resources management in Pingquan City.(3)According to scenario-based predic-tion,WRCC may slightly decline between 2025 and 2030,reaching 2.92 and 2.94,respectively,relative to 2020 levels.Therefore,future efforts should focus on strengthening scientific management and promoting the efficient use of water resources.Proactive measures are necessary to mitigate emerging contradiction and ensure the long-term stability and sustainability of the water resources system in the region.The evalua-tion system and spatiotemporal evolution patterns proposed in this study can provide a scientific basis for refined water resource management and ecological conservation in similar hilly areas.
基金supported by the ability establishment of sustainable use for valuable Chinese medicine resources(Grant No.2060302)the National Key R&D Program of China(Grant No.2018YFA0900603)+1 种基金the National Key R&D Program of China(Grant No.2020YFA0908000)the crosswise task based on DEYUANTANG pharmacy Co.,Ltd.Shanxi,China(Grant No.DYTKY180725).
文摘Safflower is an important oilseed crop that has been used in traditional Chinese medicine for thousands of years because of the clinically valuable flavonoid glycosides in its flower petals.However,the biosynthesis and molecular regulation of these compounds are still elusive due to the lack of a high-quality reference genome and scarce identification of key biosynthetic pathway genes in a medicinal safflower variety.Here we leveraged an integrative multi-omics strategy by combining genomic,comparative genomics,and tissue-specific transcriptome profiling with biochemical analysis to identify uridine diphosphate glycosyltransferases(UGTs)for flavonoid glycoside biosynthesis in safflower.We assembled and annotated a high-quality reference genome of a medicinal safflower variety,‘Yunhong3’.A comprehensive comparative genomic analysis indicated that an evolutionary whole-genome triplication event occurring in safflower contributed to gene amplification of the flavonoid biosynthetic pathway.By combining comparative transcriptome profiling with enzymatic reactions,we identified 11 novel UGTs that could catalyze the conversion of naringenin chalcone and phloretin to the corresponding O-glycosides.Moreover,we outlined the molecular pathway of hydroxysafflor yellow A(HSYA)biosynthesis featured by 17 newly identified UGTs with promising catalytic activity,laying the foundation for the synthetic production of HSYA.Our study reports systemic genome and gene expression information for flavonoid glycoside biosynthesis in medicinal safflower and provides insights into mechanisms regulating HSYA biosynthesis,which would facilitate the genetic improvement and synthetic bioengineering design for producing clinically valuable flavonoid glycosides in safflower.
基金National Natural Science Foundation of China,No.42101252。
文摘Rapid regional population shifts and spatial polarization have heightened pressure on cultivated land—a critical resource demanding urgent attention amid ongoing urban-rural transition.This study selects Jiangsu province,a national leader in both economic and agricultural development,as a case area to construct a multidimensional framework for assessing the recessive morphological characteristics of multifunctional cultivated land use.We examine temporal dynamics,spatial heterogeneity,and propose an integrated zoning strategy based on empirical analysis.The results reveal that:(1)The recessive morphology index shows a consistent upward trend,with structural breaks in 2007 and 2013,and a spatial shift from“higher in the east and lower in the west”to“higher in the south and lower in the north.”(2)Coordination among sub-dimensions of the index has steadily improved.(3)The index is expected to continue rising in the next decade,though at a slower pace.(4)To promote coordinated multidimensional land-use development,we recommend a policy framework that reinforces existing strengths,addresses weaknesses,and adapts zoning schemes to current spatial conditions.This research offers new insights into multifunctional cultivated land systems and underscores their role in enhancing human well-being,securing food supply,and supporting sustainable urban-rural integration.
基金supported by the National Natural Science Foundation of China(Grant No.51379181)Phase Ⅲ Project(2018-2021)of the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘Based on the regional water resources carrying capacity(WRCC)evaluation principles and evaluation index system in the National Technical Outline of Water Resources Carrying Capacity Monitoring and Early Warning(hereafter referred to as the Technical Outline),this paper elaborates on the collection and sorting of the basic data of water resources conditions,water resources development and utilization status,social and economic development in basins,analysis and examination of integrity,consistency,normativeness,and rationality of the basic data,and the necessity of WRCC evaluation.This paper also describes the technique of evaluating the WRCC in prefecture-level cities and city-level administrative divisions in the District of the Taihu Lake Basin,which is composed of the Taihu Lake Basin and the Southeastern River Basin.The evaluation process combines the binary index evaluation method and reduction index evaluation method.The former,recommended by the Technical Outline,uses the total water use and the amount of exploited groundwater as evaluation indices,showing stronger operability,while the latter is developed by simplifying and optimizing the comprehensive index system with greater systematicness and completeness.The mutual validation and adjustment of the results of the above-mentioned two evaluation methods indicate that the WRCC of the District of the Taihu Lake Basin is overloaded in general because some prefecture-level cities and city-level administrative divisions in the Taihu Lake Basin and the Southeastern River Basin are in a severely overloaded state.In order to explain this conclusion,this paper analyzes the causes of WRCC overloading from the aspects of basin water environment,water resources development and utilization,water resources regulation and control ability,water resources utilization efficiency,and water resources management.
基金National Key Project on Basic Research(973),No.2010CB951003The National Science and Technology Project,No.2014BAD10B06
文摘Water demand increases continuously with an increasing population and economic development. As a result, the difference between water supply and demand becomes a sig- nificant issue, especially in arid regions. To figure out the utilization of water resources in the arid region of northwestern China （ARNWC）, and also to provide methodologies to predict the water use in future, three models were established in this study to calculate agricultural irri- gation, industrial and domestic water use in the ARNWC from the late 1980s to 2010. Based on river discharges in the region, the supply and demand of water resources at the river basin level were analyzed. The results indicated that agricultural irrigation demand occupies more than 90% of the total water use in the ARNWC. Total water demand increased from 31.97 km3 in the late 1980s to 48.19 km3 in 2010. Most river basins in this arid region were under me- dium and high water stress. Severe-risk river basins, such as the Shiyang river basin and the eastern part of the northern piedmont of the Tianshan Mountains, were found in this region. It was revealed that the water supply became critical from April to May, which was the season of the lowest water supply as determined by comparing monthly water consumption.
基金funded by the National Natural Science Foundation of China(9102500230970492)+2 种基金the Fundamental Research Funds for the Central Universities(GK201101002)the Key Project of the Chinese Academy of Sciences(KZZDEW-04-05)the National Key Technology R & D Program(2012BAC08B05)
文摘This paper, based on the analysis and calculation of the groundwater resources in an arid region from 1980 to 2001, put forward the concept of ecological groundwater level threshold for either salinity control or the determination of ecological warning. The surveys suggest that soil moisture and soil salinity are the most important environmental factors in determining the distribution and changes in vegetation. The groundwater level threshold of ecological warning can be determined by using a network of groundwater depth observation sites that monitor the environmental moisture gradient as reflected by plant physiological characteristics. According to long-term field observations within the Ejin oases, the groundwater level threshold for salinity control varied between 0.5 m and 1.5 m, and the ecological warning threshold varied between 3.5 m and 4.0 m. The quantity of groundwater re- sources （renewable water resources, ecological water resources, and exploitable water resources） in arid areas can be calculated from regional groundwater level information, without localized hydrogeological data. The concept of groundwater level threshold of ecological warning was established according to water development and water re- sources supply, and available groundwater resources were calculated. The concept not only enriches and broadens the content of groundwater studies, but also helps in predicting the prospects for water resources development.
基金Acknowledgment This study was supported by the National Key Basic Research Development Program Project （2010CB428400） and the Natural Science Foundation of China （51279140）.
文摘This paper addresses the impact of climate change on the water cycle and resource changes in the Eastern Monsoon Region of China （EMRC）. It also represents a summary of the achievements made by the National Key Basic Research and Development Program （2010CB428400）, where the major research focuses are detection and attribution, extreme floods and droughts, and adaptation of water resources management. Preliminary conclusions can be summarized into four points： 1） Water cycling and water resource changes in the EMRC are rather complicated as the region is impacted by natural changes relating to the strong monsoon influence and also by climate change impacts caused by CO2 emissions due to anthropogenic forcing; 2） the rate of natural variability contributing to the influence on precipitation accounts for about 70%, and the rate from anthropogenic forcing accounts for 30% on average in the EMRC. However, with future scenarios of increasing CO2 emissions, the contribution rate from anthropogenic forcing will increase and water resources management will experience greater issues related to the climate change impact; 3） Extreme floods and droughts in the EMRC will be an increasing trend, based on IPCC-AR5 scenarios; 4） Along with rising temperatures of 1 ~C in North China, the agricultural water consumption will increase to about 4% of total water consumption. Therefore, climate change is making a significant impact and will be a risk to the EMRC, which covers almost all of the eight major river basins, such as the Yangtze River, Yellow River, Huaihe River, Haihe River, and Pearl River, and to the South-to-North Water Diversion Project （middle line）. To ensure water security, it is urgently necessary to take adaptive countermeasures and reduce the vulnerability of water resources and associated risks.
基金This work was supported in part by the National Science Foundation Project of P.R.China under Grant No.52071349,No.U1906234partially supported by the Open Project Program of Key Laboratory ofMarine Environmental Survey Technology and Application,Ministry of Natural Resource MESTA-2020-B001+1 种基金Young and Middle-aged Talents Project of the State Ethnic Affairs Commission,the Crossdisciplinary Research Project of Minzu University of China(2020MDJC08)the Graduate Research and Practice Projects of Minzu University of China(SZKY2021039).
文摘A large number of nodule minerals exist in the deep sea.Based on the factors of difficulty in shooting,high economic cost and high accuracy of resource assessment,large-scale planned commercial mining has not yet been conducted.Only experimental mining has been carried out in areas with high mineral density and obvious benefits after mineral resource assessment.As an efficient method for deep-sea mineral resource assessment,the deep towing system is equipped with a visual system for mineral resource analysis using collected images and videos,which has become a key component of resource assessment.Therefore,high accuracy in deep-sea mineral image segmentation is the primary goal of the segmentation algorithm.In this paper,the existing deep-sea nodule mineral image segmentation algorithms are studied in depth and divided into traditional and deep learning-based segmentation methods,and the advantages and disadvantages of each are compared and summarized.The deep learning methods show great advantages in deep-sea mineral image segmentation,and there is a great improvement in segmentation accuracy and efficiency compared with the traditional methods.Then,the mineral image dataset and segmentation evaluation metrics are listed.Finally,possible future research topics and improvement measures are discussed for the reference of other researchers.
基金National Natural Science Foundation of ChinaNo.49631020+1 种基金The Key Project of "inth Five-Year Plan" of the National Program for Science and TechnologyNo.2000-K01-02-01
文摘Western China includes 12 provincial divisions (the 7 provinces of Sichuan, Guizhou, Yunnan, Shaanxi, Gansu, Qinghai and; 5 autonomous regions of Tibet, Ningxia, Xinjiang, Inner Mongolia and Guangxi; and one city of Chongqing), which comprise 71.4% of the national land area, 28.5% of the national population and produce 17.5% of the national GDP in China. There are 17 countries that have riparian relationships with western China, most of which are water-short countries. All are listed by UN ESCAP as countries with potential water crisis. The co-operative development and coordinated management of international rivers in western China is an important step toward the implementation of the national Great Western Development program. Taking into account of the national strategy and object hierarchy, as well as the development demand of the western region, it is necessary to pursue the multi-disciplinary study of the equitable allocation, utilisation, and eco-environment protection of transboundary water resources in the region. Such efforts will undoubtedly provide scientific evidence and support for the decision-making of the environmental protection and ecological construction and management in the western regions, the enforcement of the sub-regional economic co-operation, mitigation of trans-boundary conflicts, and enhancing bio-diversity conservation.
文摘Shannan Prefecture of Tibet is the central producing region of Tibetan chicken, and Tibetan chicken feeding has become one of the characteristic industries of animal husbandry in local agricultural and pastoral area, and it is an important source of food and income for the locals. However, because of extensive feed- ing managemem, low level of intensification, blind hybrid of exotic varieties and despising selective breeding, the number of pedigree Tibetan chickens have reduced year by year and the performance of Tibetan chicken herd varied greatly, premium specificity could not be effectively utihzed. By investigating the present situation of Tibetan chicken feeding, analyzing the specificity of Tibetan chicken germplasm resources, the scientific conservation breeding was started to make full use of the advantage of keeping Tibetan chickens on the plateau.
基金This work was supported by the China National Natural Science Foundation No.(61331013)the Young faculty scientific research ability promotion program of Minzu University of China.
文摘Readability is a fundamental problem in textbooks assessment.For low resources languages(LRL),however,little investigation has been done on the readability of textbook.In this paper,we proposed a readability assessment method for Tibetan textbook(a low resource language).We extract features based on the information that are gotten by Tibetan segmentation and named entity recognition.Then,we calculate the correlation of different features using Pearson Correlation Coefficient and select some feature sets to design the readability formula.Fit detection,F test and T test are applied on these selected features to generate a new readability assessment formula.Experiment shows that this new formula is capable of assessing the readability of Tibetan textbooks.
文摘This study focused on the investigation of crop germplasm resources in coastal areas of Shandong Province, including 132 villages in 82 towns of 34 counties. The survey collected local varieties and wild resources of grain crops, economic crops, vegetables and fruit trees, and a total of 848 samples were collected, belonging to 54 species of 39 genera in 15 families. In this study, the current situation and growth and decline conditions of crop germplasm resources were investigated, and their botanical classification and utilization importance were analyzed. Furthermore, the conservation, development and utilization of crop germplasrp resources in coastal areas of Shandong Province were also discussed in this paper.
基金supported in part by an award from the VHA Office of Rural Health,Veterans Rural Health Resource CenterDIowa City(VRHRC-IC),Iowa City VA Health Care System,Iowa City,IA(Award#7345)。
文摘Dear Editor,Te Veterans Health Administration(VHA)provides healthcare for over 9 million enrolled veterans with approximately 2.7 million of those residing in rural areas[1].Te MISSION Act of 2018 emphasizes VHA collaboration with Federally Qualifed Healthcare Centers(FQHC)to serve rural residing veterans and nearly all existing collaborations involve arrangement of payment for community-based care by VHA to FQHCs.Unfortunately,there is a paucity of descriptive clinical data on existing cross-system collaborations which may help characterize these veterans and aid understanding of conditions for which they may receive treatment across systems.Such data has implications for workforce training,development,and resource allocation[2].Te objective of this report is to describe diferent clinical profles between two mutually exclusive samples:veterans engaged in FQHC only use,and VHA-enrolled veterans engaged in dual VHA and FQHC use.
基金Central Major Expenditure Increase or Decrease Program(2060302)Special Fund for Guiding Local Science and Technology Development by the Central Government(2018SZYD0003)+1 种基金Sichuan Provincial Science and Technology Department Talent Project(2016RZ0061)Sichuan Traditional Chinese Medicine Resources Sustainable Development Strategy Research Project(2016ZR0069).
文摘Polygonatum is a traditional and precious Chinese medicine in China,as well as a traditional medicinal and food homologous material.It has a long history of cultivation and medicinal use.It not only has the effects of boosting qi and nourishing yin,nourishing the spleen and lungs,and tonifying the kidney,but also application value in food,health products,ornamental,cosmetics,etc.There are many varieties of Polygonatum resources all over China,which are easy to be mixed.There are three species of medicinal Polygonatum recorded in the 2015 edition of Pharmacopeia of the People s Republic of China.In order to sustainably use and fully develop Polygonatum medicinal resources,we conducted textual research on relevant data and research on the distribution of Polygonatum resources,germplasm identification,genetic diversity and breeding research,so as to provide a reference for the selection and breeding of polygonatum,artificial cultivation and the development and utilization of potential Polygonatum resources and for the solution of the contradiction between supply and demand in the Polygonatum market.
文摘This paper discusses the Project's organization system, technical system, creation of digital resources and service mode. It also summarizes achievements gained since the commencement of the Project, and also analyzes some of the more important issues during implementation stage and gives a few suggestions of the future development during the next stage of the 11thFive-Year Plan.
文摘Talent is the inexhaustible driving force for the development of enterprises. In the development of enterprises, the importance of talent gradually highlighted. Pay great attention to human resources compensation management and human resources compensation management quality has become an important factor affecting the development and progress of enterprises. Enterprises need talents to promote their development. Human resource management can provide high-quality talents for enterprise and improve their competitive advantages and guide enterprises to develop efficiently and maximize economic benefits. Human resource compensation management can reasonably design salary treatment based on employees' performance, motivate employees' enthusiasm, guide employees to efficiently complete their own work under reasonable salary management and greatly improve work efficiency and quality. Although enterprises attach more importance to human resource compensation management, in the actual implementation process, there are still problems such as unreasonable compensation design, backward management system and concept, and imperfect compensation incentive mechanism, leading to the low quality of human resource compensation management. In view of the problems existing in the salary management, enterprises should take countermeasures according to the actual situation, scientifically and reasonably design the salary, improve the salary incentive mechanism, realize the common development of employees and enterprises, improve the core competitiveness of enterprises and occupy a favorable position in the fierce market competition.
