The paper is an introduction to the front-end pulse acquisition and the back-end pulse biomimetic reproduction system.This system is capable of faithfully replicating the complete pulse waveform collected at the front...The paper is an introduction to the front-end pulse acquisition and the back-end pulse biomimetic reproduction system.This system is capable of faithfully replicating the complete pulse waveform collected at the front end.Traditional Chinese Medicine(TCM)practitioners analyze and diagnose the pulse patterns at the replication end.Meanwhile,the obtained pulse waveforms are analyzed and learnt by a neural network based on key diagnostic points in TCM pulse taking,which enables the determination of the corresponding relationships between different pulse waveforms and various pulse patterns in TCM pulse taking.With the support of clinical samples,an auxiliary diagnostic system for TCM pulse patterns ensures the accuracy of pulse pattern replication.展开更多
Cordyceps is treasured entomopathogenic fungi that have been used as antitumor,immunomodulating,antioxidant,and pro-sexual agent.Cordyceps,also called DongChongXiaCao in Chinese,Yartsa Gunbu(Tibetan),means winter worm...Cordyceps is treasured entomopathogenic fungi that have been used as antitumor,immunomodulating,antioxidant,and pro-sexual agent.Cordyceps,also called DongChongXiaCao in Chinese,Yartsa Gunbu(Tibetan),means winter worm-summer grass.Natural Cordyceps sinensis with parasitic hosts is difficult to be collected and the recent findings on its potential pharmacological functions,resulted in skyrocketing prices.Therefore,finding a mass-production method or an alternative for C.sinensis products is a top-priority task.In this review,we describe current status of Cordyceps research and its recent developments in Taiwan.The content and pharmacological activities of four major industrial species of Cordyceps(C.sinensis,Cordyceps militaris,Cordyceps cicadae and Cordyceps sobolifera)used in Taiwan,were reviewed.Moreover,we highlighted the effect of using different methods of fermentation and production on the morphology and chemical content of Cordyceps sp.Finally,we summarized the bottle-necks and challenges facing Cordyceps research as well as we proposed future road map for Cordyceps industry in Taiwan.展开更多
Dear Researchers,Journal of Architectural Research and Development is an international peer-reviewed and high quality open access journal which is devoted to establish a bridge between theory and practice in the field...Dear Researchers,Journal of Architectural Research and Development is an international peer-reviewed and high quality open access journal which is devoted to establish a bridge between theory and practice in the fields of architectural and design research,urban planning and built environment research.展开更多
Dear Researchers,Journal of Architectural Research and Development is an international peer-reviewed and high quality open access journal which is devoted to establish a bridge between theory and practice in the field...Dear Researchers,Journal of Architectural Research and Development is an international peer-reviewed and high quality open access journal which is devoted to establish a bridge between theory and practice in the fields of architectural and design research,urban planning and built environment research.展开更多
Dear Researchers,Journal of Architectural Research and Development is an international peer-reviewed and high quality open access journal which is devoted to establish a bridge between theory and practice in the field...Dear Researchers,Journal of Architectural Research and Development is an international peer-reviewed and high quality open access journal which is devoted to establish a bridge between theory and practice in the fields of architectural and design research,urban planning and built environment research.展开更多
Dear Researchers,Journal of Architectural Research and Development is an international peer-reviewed and high quality open access journal which is devoted to establish a bridge between theory and practice in the field...Dear Researchers,Journal of Architectural Research and Development is an international peer-reviewed and high quality open access journal which is devoted to establish a bridge between theory and practice in the fields of architectural and design research,urban planning and built environment research.展开更多
The application of traditional Chinese medicine in skincare formula development was expounded from the views of“symptom,theory,method,prescription,medicine and effect”.Traditional Chinese medicine prescriptions were...The application of traditional Chinese medicine in skincare formula development was expounded from the views of“symptom,theory,method,prescription,medicine and effect”.Traditional Chinese medicine prescriptions were improved according to the laws and regulations for China’s cosmetic industry and by the modern scientific and technological means,which had important guiding significance for the research and development of plant-based functional skincare products.The problems in concept claim and quality control standard,and the problems of market confusion,which were ascribed to the lack of basic research in the application of Chinese herbal cosmetics,were pointed out.The future development direction of plant-based functional cosmetics guided by TCM theory was prospected.展开更多
Continued population growth and limited land availability will facilitate the utilization of plant growth regulators(PGRs)in sustainable agriculture to enhance crop yields.The PGRs industry has progressed significantl...Continued population growth and limited land availability will facilitate the utilization of plant growth regulators(PGRs)in sustainable agriculture to enhance crop yields.The PGRs industry has progressed significantly from 2003 to 2022,resulting in a surge of research activities in the field of PGRs.However,the existing studies lack the exploration of the industry trends,as well as the challenges and opportunities for innovation in PGR development.Here,we analyze the dynamic trends within the PGR industry by examining key factors such as the PGR market,patent applications,scientific papers,and PGRs registrations from 2003 to 2022.Additionally,we investigate the specific effects of major agrochemicals on plants.These data will provide essential insights into the ongoing evolution and future trends of PGRs.Importantly,it is crucial to actively pursue research and development(R&D)of a broader range of PGRs to respond to the current needs of the PGR market and drive further growth therein.展开更多
1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many ...1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging.展开更多
With the growth of global protein demand and the development of plant-based foods,pea protein,as a low-allergenic,nutritionally balanced and environmentally friendly plant protein,has shown great potential in replacin...With the growth of global protein demand and the development of plant-based foods,pea protein,as a low-allergenic,nutritionally balanced and environmentally friendly plant protein,has shown great potential in replacing animal protein.Pea protein is mainly composed of globulin and albumin,with a protein content of 20%to 30%,and has a balanced amino acid composition,as well as being rich in minerals and dietary fiber.It also possesses good foaming,gelling,emulsifying and antioxidant functional properties.However,pea protein also has inherent defects that limit its application in the food industry.This article systematically reviews the extraction techniques,functional properties,modification methods and application fields of pea protein,and focuses on evaluating the effects of different extraction and modification strategies on protein yield and functional properties.Research shows that ultrasonic-assisted alkaline extraction can reduce solvent usage by 55%,shorten extraction time by 50%,and increase extraction rate by 12.51%;under optimized conditions,ultrafiltration membrane technology can achieve a protein purity of 91%.In terms of modification,ultrasonic treatment increases foaming capacity by 37.4%,and phenolic cross-linking increases gel strength from 3.0 kPa to 48 kPa.This article provides data support and theoretical reference for the efficient extraction and functional optimization of pea protein,and has promoting significance for its wide application in plant-based foods.展开更多
Significant exploration progress has been made in ultra-deep clastic rocks in the Kuqa Depression,Tarim Basin,over recent years.A new round of comprehensive geological research has formed four new understandings:(1)Es...Significant exploration progress has been made in ultra-deep clastic rocks in the Kuqa Depression,Tarim Basin,over recent years.A new round of comprehensive geological research has formed four new understandings:(1)Establish structural model consisting of multi-detachment composite,multi-stage structural superposition and multi-layer deformation.Multi-stage structural traps are overlapped vertically,and a series of structural traps are discovered in underlying ultra-deep layers.(2)Five sets of high-quality large-scale source rocks of three types of organic phases are developed in the Triassic and Jurassic systems,and forming a good combination of source-reservoir-cap rocks in ultra-deep layers with three sets of large-scale regional reservoir and cap rocks.(3)The formation of large oil and gas fields is controlled by four factors which are source,reservoir,cap rocks and fault.Based on the spatial configuration relationship of these four factors,a new three-dimensional reservoir formation model for ultra-deep clastic rocks in the Kuqa Depression has been established.(4)The next key exploration fields for ultra-deep clastic rocks in the Kuqa Depression include conventional and unconventional oil and gas.The conventional oil and gas fields include the deep multi-layer oil-gas accumulation zone in Kelasu,tight sandstone gas of Jurassic Ahe Formation in the northern structural zone,multi-target layer lithological oil and gas reservoirs in Zhongqiu–Dina structural zone,lithologic-stratigraphic and buried hill composite reservoirs in south slope and other favorable areas.Unconventional oil and gas fields include deep coal rock gas of Jurassic Kezilenuer and Yangxia formations,Triassic Tariqike Formation and Middle-Lower Jurassic and Upper Triassic continental shale gas.The achievements have important reference significance for enriching the theory of ultra-deep clastic rock oil and gas exploration and guiding the future oil and gas exploration deployment.展开更多
Purpose–The study aims to build a high-precision longitudinal dynamics model for heavy-haul trains and validate it with line test data,present an optimization method for multi-stage cyclic brakes based on the model a...Purpose–The study aims to build a high-precision longitudinal dynamics model for heavy-haul trains and validate it with line test data,present an optimization method for multi-stage cyclic brakes based on the model and conduct a multi-objective detailed evaluation of the driver’s manipulation during cyclic braking.Design/methodology/approach–The high-precision longitudinal train dynamics model was established and verified by the cyclic braking test data of the 20,000 t heavy-haul combination train on the long and steep downgrade.Then the genetic algorithm is employed for optimization subsequent to decoupling multiple cyclic braking procedures,with due consideration of driver operation rules.For evaluation,key manipulation assessments in the scenario are prioritized,supplemented by multi-objective evaluation requirements,and the computational model is employed for detailed evaluation analysis.Findings–Based on the model,experimental data reveal that the probability of longitudinal force error being less than 64.6 kN is approximately 68%,95%for less than 129.2 kN and 99.7%for less than 193.8 kN.Upon optimizing manipulations during the cyclic braking,the maximum reduction in coupler force spans from 21%∼23.9%.Andtheevaluation scoresimply that a proper elevationof the releasingspeed favorssafety.A high electric braking force,although beneficial to some extent for energy-saving,is detrimental to reducing coupler force.Originality/value–The results will provide a theoretical basis and practical guidance for further ensuring the safety and energy-efficient operation of heavy haul trains on long downhill sections and improving the operational quality of heavy-haul trains.展开更多
Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institut...Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institutions,construction sites,professional fields,etc.,to provide a reference for the further improvement and optimization of the national science and technology innovation platform system in the railway industry.Design/methodology/approach–Through literature review,field investigation,expert consultation and other methods,this paper systematically investigates and analyzes the development status of the national science and technology innovation platform in the railway industry.Findings–Taking the national science and technology innovation platform of the railway industry as the research object,this paper investigates and analyzes the construction,development and distribution of the national science and technology innovation platform of railway industry over the years.And the National Engineering Research Center of High-speed Railway and Urban Rail Transit System Technology was taken as an example to introduce its operation effect.Originality/value–China Railway has made great development achievements,with the construction and development of national science and technology innovation platform in the railway industry.In recent years,a large number of national science and technology innovation platforms have been built in the railway industry,which play an important role in railway technological innovation,standard setting and commodification,and Railway Sciences provide strong support for railway technology development.展开更多
Precise and quantitative measurement of soot particle emission plays an essential role in accurately assessing the combustion performance of aero-engine combustors and infrared signature levels in aircraft exhausts.Am...Precise and quantitative measurement of soot particle emission plays an essential role in accurately assessing the combustion performance of aero-engine combustors and infrared signature levels in aircraft exhausts.Among various intrusive or non-intrusive approaches for soot diagnostics,Laser-Induced Incandescence(LⅡ)technique has been increasingly applied for soot concentration measurement in various combustion environments such as laminar flames and internal combustion engines due to its high spatial resolution and sensitivity.As for LⅡmeasurement in aero-engine combustors,however,it normally suffers from very limited optical accesses and often faces mandatory requirements of oblique imaging from a small backward angle.In this work,we demonstrate a Two-Color(2C)LⅡsystem that simultaneously captures LⅡsignal images at two distinct wavelengths using a Scheimpflug imaging configuration.A projective transformation algorithm and image overlapping procedures were employed to spatially correct the raw Scheimpflug LⅡimages.Performance validation of the developed 2C-Scheimpflug LⅡsystem was first conducted under specified conditions in a laminar C_(2)H_(4)/air McKenna flame.The obtained Soot Volume Fraction(SVF)level and its spatial distribution are in consistent with previous studies under identical flame conditions reported by other research groups.Finally,as a demonstration of engineering benchmark application,we applied the developed 2C-Scheimpflug LⅡsystem to measure SVF distribution in the cross-section plane perpendicular to the direction of flame propagation at the exhaust of a single-sector dual-swirl aero-engine model combustor.Transient soot production events were observed and characteristics of the SVF distribution were investigated.These experimental results suggest the feasibility of the 2C-Scheimpflug LⅡtechnique developed in this work for precise and quantitative measurements of soot concentration in practical environments.展开更多
Survivin was firstly separated in hybridization of Effector Cell Protease Receptor-1(EPR-1)cDNA in human genome by Yale University's Ambrosini in 1997,which is member of the inhibitor of apoptosis proteins(IAPS).U...Survivin was firstly separated in hybridization of Effector Cell Protease Receptor-1(EPR-1)cDNA in human genome by Yale University's Ambrosini in 1997,which is member of the inhibitor of apoptosis proteins(IAPS).Unlike other IAP protein,found during embryonic and fetal development,survivin wascompletely down-regulated and undetectable in normal adult tissues,and became prominentlyre expressed in all of the most common cancers.It through includes the cysteine/histidine rod-shaped viral IAP repetition sequence baculoviral IAP repeats(BIRs)the structure territory directly or intervenes Caspases the function to display indirectly its anti-perishes weakly the function,simultaneously it also is in the cell division process the chromosome traveler protein(chromosome passenger protein).There are three approaches by which survivin inhibits the processing of apoptosis:(1)inhibits processing of down stream effector caspase-3,caspase-7and caspase-9 in cell receiving apoptotic stimuls;(2)with the Smac/DIABLO function,sends the XIAP activeness to increase,XIAP through directly affects and restrains its function with caspases,achieved restrains function which perishes weakly;(3)through restrains p53 the function to block perishes weakly the process.Survivin expressed specificity and its function multiplicity.Survivin only expresses in tumor tissues and cannot be found in normal terminally differentiated tissues.This kind of expression is been extremely low the cell cycle strict regulation in the G1 time expression,the S time is G1 time 6 times,the G2/M time advances to 40 times,demonstrated its expression has the G2/M time dependence specificity.It has bi-function of inhibiting apoptosis and involving in cell cycle control.Survivin has found in most of tumor cells in recently researches.Survivin expresses generally in all tumor cell line in the American State-run Cancer Research institute anti-tumor medicine screening procedure 60 different tumor cells,in which expresses in the mammary gland cancer cell and the lung cancer cell highly,expresses in the kidney cancer lowly.Survivin except in tumor cell high expression,at breast cancer,tumor in front of and so on endometrium cancer,cervical cancer cancers in the pathological change has the expression.Survivin is over expressed in early malignant,which brokes the balance of proliferation and apoptotic,causes the occurrence of tumor.Obviously,survivin is closely related to the uncontrolled growth carcinogenesis,development and tumorigenesis.Because Survivin in tumor organization's special expression and perishes weakly in the suppression cell and adjusts in the cell division the vital role,causes it to become one to have the latent application value tumor designated object and the tumor treatment new target spot.The recent research of survivin in the development,treatment and situation of tumor is introduced.展开更多
In recent years, with the rapid development of large-scale distributed wireless sensor systems and micro-power devices, the disadvantages of traditional chemical battery power supply mode are becoming more and more ob...In recent years, with the rapid development of large-scale distributed wireless sensor systems and micro-power devices, the disadvantages of traditional chemical battery power supply mode are becoming more and more obvious. Piezoelectric energy collector has attracted wide attention because of its simple structure, no heating, no electromagnetic interference, environmental protection and easy miniaturization. Wind energy is a reproducible resource. Wind energy harvester based on piezoelectric intelligent material can be named piezoelectric wind energy harvesting which converts wind energy into electric power and will have great application prospect. To promote the development of piezoelectric wind energy harvesting technology, research statuses on piezoelectric wind energy harvesting technology are reviewed. The existing problem and development direction about piezoelectric wind energy harvester in the future are discussed. The study will be helpful for researchers engaged in piezoelectric wind energy harvesting.展开更多
In the past two decades, the oxy-fuel combustion of pulverized coal has been extensively developed, leading to the completion of several large industrial pilot oxy-fuel plants worldwide. Various types of oxy-fuel burn...In the past two decades, the oxy-fuel combustion of pulverized coal has been extensively developed, leading to the completion of several large industrial pilot oxy-fuel plants worldwide. Various types of oxy-fuel burners have been designed and tested in largescale pilot plants as key components of oxy-fuel combustion. These burners face major challenges in terms of their flame stability because of their decreasing stream momentum ratio and increasing carbon dioxide concentration. However, it offers flexibility in adjusting the oxygen concentration in each burner stream. This study aims to provide a comprehensive review of the state-of-the-art knowledge on oxy-coal burner design and operation in power plants. First, the combustion characteristics under oxy-fuel conditions are briefly introduced. Subsequently, the principal requirements and fundamental parameters of the oxy-coal burners are discussed. The development process of oxy-fuel burners is also presented. Moreover, a compatible design strategy and scaling-up techniques are described for oxy-coal burners developed by the authors over the past ten years. The performances of oxy-coal burners in three large pilot oxy-fuel plants worldwide are summarized and compared. Finally, concluding remarks are provided and potential research needs are suggested.展开更多
Objective:This study was performed to investigate the relationship between the human melanogenesis and antioxidant systems and to further confirm the synergistic effect of oxyresveratrol(OXYR)and resveratrol(RES)in hu...Objective:This study was performed to investigate the relationship between the human melanogenesis and antioxidant systems and to further confirm the synergistic effect of oxyresveratrol(OXYR)and resveratrol(RES)in human epidermal melanocyte cell line.Methods:The human epidermal melanocyte line PIG1 cells were divided into the UV groups and control group,treated with different doses of UVB and without UVB,respectively.MTT assay and flow cytometry were used to detect cell viability and apoptosis.The expression of Nrf2/HO-1 and melanogenesis-associated proteins/genes was measured by Western blotting and real-time qPCR(RT-qPCR).pCMV6-XL5-Nrf2 was used to upregulate the expression of Nrf2.Subsequently,the proteins/genes levels of Nrf2/HO-1 and tyrosinase(TYR),melanin/eumelanin content,and reactive oxygen species(ROS)were analyzed.Isobologram analysis and cell experiment were used to analyze whether OXYR and RES inhibit TYR synergistically.Western blotting,RT-qPCR,and NaOH splitting method were used to determine the Nrf2/HO-1 and melanogenesis-associated proteins/genes expression and melanin content to evaluate the efficacy of OXYR and RES.Results:The activated Nrf2 and HO-1 eliminated ROS produced by UVB irradiation.The melanogenesis-associated proteins/genes of melanocyte-inducing transcription factor(MITF,P<0.01 on protein expression),TYR(both P<0.01),TYR-related protein(TRP)-1(both P<0.05),and TRP2(P<0.05 on mRNA expression)were activated in PIG1 cells by UVB irradiation.Simultaneously,the upregulation of Nrf2 significantly reduced melanogenesis formation(P<0.001)and TYR level(P<0.01 on protein expression).Moreover,OXYR and RES synergistically inhibited TYR activity(P<0.001)and reduced melanin content(P<0.001).Conclusions:A microbalance exists between Nrf2/HO-1 signaling and melanogenesis production in the UVBinduced responses of melanocytes.Simultaneously,OXYR enhances the ability of RES to inhibit melanin production.展开更多
Over a century ago,the first clinical and neuropathological insights into major neurodegenerative diseases began to emerge:the description of Alzheimer’s disease(AD)by Alois Alzheimer in 1906,frontotemporal dementia ...Over a century ago,the first clinical and neuropathological insights into major neurodegenerative diseases began to emerge:the description of Alzheimer’s disease(AD)by Alois Alzheimer in 1906,frontotemporal dementia by Arnold Pick in the same years,and Lewy bodies by Friedrich Lewy in 1912.These foundational studies laid the groundwork for the classification of what we now recognize as distinct neurodegenerative entities(Allali,2024).展开更多
The substitution of TiO_(2)for SiO_(2)in Y_(2)O_(3)-Li_(2)O-Al_(2)O_(3)-SiO_(2)(YLAS)glass-ceramics significantly altered their crystallization behavior and properties.Introducing TiO_(2)reduced the glass transition t...The substitution of TiO_(2)for SiO_(2)in Y_(2)O_(3)-Li_(2)O-Al_(2)O_(3)-SiO_(2)(YLAS)glass-ceramics significantly altered their crystallization behavior and properties.Introducing TiO_(2)reduced the glass transition temperature while increasing the crystallization peak temperature and lowering activation energy,which facilitated crystallization.The crystal growth shifted from three-dimensional to two-dimensional,and the primary phases transitioned from Al_(9.83)Zr_(0.17)and Y_(2)Si_(2)O_(7)to Y_(4.67)(SiO_(4))_(3)O,though crystal morphology remained unchanged.Grain size increased with higher crystallization temperatures.Mechanically,Vickers hardness slightly decreased(from 796 to 784 Hv),while bending strength improved(from 141 to 146 MPa),suggesting that TiO_(2)enhanced toughness without compromising structural integrity.The strength of the glass can be further improved through two-step ion exchange,but excessive crystallization can lead to cracks on the glass surface due to excessive surface compressive stress,resulting in a decrease in bending strength.These findings provide critical insights for optimizing YLAS glass-ceramics for advanced applications.展开更多
基金Key R&D Plan of Liaoning Province(No.202000357-JH13/103):Construction of Liaoning Traditional Chinese Medicine Industry Technology Innovation Research InstituteNational Key Research and Development Plan Special Project(No.2019JH2/10300040)。
文摘The paper is an introduction to the front-end pulse acquisition and the back-end pulse biomimetic reproduction system.This system is capable of faithfully replicating the complete pulse waveform collected at the front end.Traditional Chinese Medicine(TCM)practitioners analyze and diagnose the pulse patterns at the replication end.Meanwhile,the obtained pulse waveforms are analyzed and learnt by a neural network based on key diagnostic points in TCM pulse taking,which enables the determination of the corresponding relationships between different pulse waveforms and various pulse patterns in TCM pulse taking.With the support of clinical samples,an auxiliary diagnostic system for TCM pulse patterns ensures the accuracy of pulse pattern replication.
文摘Cordyceps is treasured entomopathogenic fungi that have been used as antitumor,immunomodulating,antioxidant,and pro-sexual agent.Cordyceps,also called DongChongXiaCao in Chinese,Yartsa Gunbu(Tibetan),means winter worm-summer grass.Natural Cordyceps sinensis with parasitic hosts is difficult to be collected and the recent findings on its potential pharmacological functions,resulted in skyrocketing prices.Therefore,finding a mass-production method or an alternative for C.sinensis products is a top-priority task.In this review,we describe current status of Cordyceps research and its recent developments in Taiwan.The content and pharmacological activities of four major industrial species of Cordyceps(C.sinensis,Cordyceps militaris,Cordyceps cicadae and Cordyceps sobolifera)used in Taiwan,were reviewed.Moreover,we highlighted the effect of using different methods of fermentation and production on the morphology and chemical content of Cordyceps sp.Finally,we summarized the bottle-necks and challenges facing Cordyceps research as well as we proposed future road map for Cordyceps industry in Taiwan.
文摘Dear Researchers,Journal of Architectural Research and Development is an international peer-reviewed and high quality open access journal which is devoted to establish a bridge between theory and practice in the fields of architectural and design research,urban planning and built environment research.
文摘Dear Researchers,Journal of Architectural Research and Development is an international peer-reviewed and high quality open access journal which is devoted to establish a bridge between theory and practice in the fields of architectural and design research,urban planning and built environment research.
文摘Dear Researchers,Journal of Architectural Research and Development is an international peer-reviewed and high quality open access journal which is devoted to establish a bridge between theory and practice in the fields of architectural and design research,urban planning and built environment research.
文摘Dear Researchers,Journal of Architectural Research and Development is an international peer-reviewed and high quality open access journal which is devoted to establish a bridge between theory and practice in the fields of architectural and design research,urban planning and built environment research.
文摘The application of traditional Chinese medicine in skincare formula development was expounded from the views of“symptom,theory,method,prescription,medicine and effect”.Traditional Chinese medicine prescriptions were improved according to the laws and regulations for China’s cosmetic industry and by the modern scientific and technological means,which had important guiding significance for the research and development of plant-based functional skincare products.The problems in concept claim and quality control standard,and the problems of market confusion,which were ascribed to the lack of basic research in the application of Chinese herbal cosmetics,were pointed out.The future development direction of plant-based functional cosmetics guided by TCM theory was prospected.
基金supported by the National Natural Science Foundation of China(32125033,32260687 and 32260688)China Postdoctoral Science Foundation(2022M710915).
文摘Continued population growth and limited land availability will facilitate the utilization of plant growth regulators(PGRs)in sustainable agriculture to enhance crop yields.The PGRs industry has progressed significantly from 2003 to 2022,resulting in a surge of research activities in the field of PGRs.However,the existing studies lack the exploration of the industry trends,as well as the challenges and opportunities for innovation in PGR development.Here,we analyze the dynamic trends within the PGR industry by examining key factors such as the PGR market,patent applications,scientific papers,and PGRs registrations from 2003 to 2022.Additionally,we investigate the specific effects of major agrochemicals on plants.These data will provide essential insights into the ongoing evolution and future trends of PGRs.Importantly,it is crucial to actively pursue research and development(R&D)of a broader range of PGRs to respond to the current needs of the PGR market and drive further growth therein.
文摘1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging.
文摘With the growth of global protein demand and the development of plant-based foods,pea protein,as a low-allergenic,nutritionally balanced and environmentally friendly plant protein,has shown great potential in replacing animal protein.Pea protein is mainly composed of globulin and albumin,with a protein content of 20%to 30%,and has a balanced amino acid composition,as well as being rich in minerals and dietary fiber.It also possesses good foaming,gelling,emulsifying and antioxidant functional properties.However,pea protein also has inherent defects that limit its application in the food industry.This article systematically reviews the extraction techniques,functional properties,modification methods and application fields of pea protein,and focuses on evaluating the effects of different extraction and modification strategies on protein yield and functional properties.Research shows that ultrasonic-assisted alkaline extraction can reduce solvent usage by 55%,shorten extraction time by 50%,and increase extraction rate by 12.51%;under optimized conditions,ultrafiltration membrane technology can achieve a protein purity of 91%.In terms of modification,ultrasonic treatment increases foaming capacity by 37.4%,and phenolic cross-linking increases gel strength from 3.0 kPa to 48 kPa.This article provides data support and theoretical reference for the efficient extraction and functional optimization of pea protein,and has promoting significance for its wide application in plant-based foods.
基金Supported by the National Natural Science Foundation of China(U22B6002)PetroChina Science and Technology Project(2023ZZ14).
文摘Significant exploration progress has been made in ultra-deep clastic rocks in the Kuqa Depression,Tarim Basin,over recent years.A new round of comprehensive geological research has formed four new understandings:(1)Establish structural model consisting of multi-detachment composite,multi-stage structural superposition and multi-layer deformation.Multi-stage structural traps are overlapped vertically,and a series of structural traps are discovered in underlying ultra-deep layers.(2)Five sets of high-quality large-scale source rocks of three types of organic phases are developed in the Triassic and Jurassic systems,and forming a good combination of source-reservoir-cap rocks in ultra-deep layers with three sets of large-scale regional reservoir and cap rocks.(3)The formation of large oil and gas fields is controlled by four factors which are source,reservoir,cap rocks and fault.Based on the spatial configuration relationship of these four factors,a new three-dimensional reservoir formation model for ultra-deep clastic rocks in the Kuqa Depression has been established.(4)The next key exploration fields for ultra-deep clastic rocks in the Kuqa Depression include conventional and unconventional oil and gas.The conventional oil and gas fields include the deep multi-layer oil-gas accumulation zone in Kelasu,tight sandstone gas of Jurassic Ahe Formation in the northern structural zone,multi-target layer lithological oil and gas reservoirs in Zhongqiu–Dina structural zone,lithologic-stratigraphic and buried hill composite reservoirs in south slope and other favorable areas.Unconventional oil and gas fields include deep coal rock gas of Jurassic Kezilenuer and Yangxia formations,Triassic Tariqike Formation and Middle-Lower Jurassic and Upper Triassic continental shale gas.The achievements have important reference significance for enriching the theory of ultra-deep clastic rock oil and gas exploration and guiding the future oil and gas exploration deployment.
文摘Purpose–The study aims to build a high-precision longitudinal dynamics model for heavy-haul trains and validate it with line test data,present an optimization method for multi-stage cyclic brakes based on the model and conduct a multi-objective detailed evaluation of the driver’s manipulation during cyclic braking.Design/methodology/approach–The high-precision longitudinal train dynamics model was established and verified by the cyclic braking test data of the 20,000 t heavy-haul combination train on the long and steep downgrade.Then the genetic algorithm is employed for optimization subsequent to decoupling multiple cyclic braking procedures,with due consideration of driver operation rules.For evaluation,key manipulation assessments in the scenario are prioritized,supplemented by multi-objective evaluation requirements,and the computational model is employed for detailed evaluation analysis.Findings–Based on the model,experimental data reveal that the probability of longitudinal force error being less than 64.6 kN is approximately 68%,95%for less than 129.2 kN and 99.7%for less than 193.8 kN.Upon optimizing manipulations during the cyclic braking,the maximum reduction in coupler force spans from 21%∼23.9%.Andtheevaluation scoresimply that a proper elevationof the releasingspeed favorssafety.A high electric braking force,although beneficial to some extent for energy-saving,is detrimental to reducing coupler force.Originality/value–The results will provide a theoretical basis and practical guidance for further ensuring the safety and energy-efficient operation of heavy haul trains on long downhill sections and improving the operational quality of heavy-haul trains.
文摘Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institutions,construction sites,professional fields,etc.,to provide a reference for the further improvement and optimization of the national science and technology innovation platform system in the railway industry.Design/methodology/approach–Through literature review,field investigation,expert consultation and other methods,this paper systematically investigates and analyzes the development status of the national science and technology innovation platform in the railway industry.Findings–Taking the national science and technology innovation platform of the railway industry as the research object,this paper investigates and analyzes the construction,development and distribution of the national science and technology innovation platform of railway industry over the years.And the National Engineering Research Center of High-speed Railway and Urban Rail Transit System Technology was taken as an example to introduce its operation effect.Originality/value–China Railway has made great development achievements,with the construction and development of national science and technology innovation platform in the railway industry.In recent years,a large number of national science and technology innovation platforms have been built in the railway industry,which play an important role in railway technological innovation,standard setting and commodification,and Railway Sciences provide strong support for railway technology development.
基金supported by the Equipment Test and Evaluation Technology Research Project,China(No.2100070017)the Natural Science Foundation of Gansu Province,China(No.24JRRA415)。
文摘Precise and quantitative measurement of soot particle emission plays an essential role in accurately assessing the combustion performance of aero-engine combustors and infrared signature levels in aircraft exhausts.Among various intrusive or non-intrusive approaches for soot diagnostics,Laser-Induced Incandescence(LⅡ)technique has been increasingly applied for soot concentration measurement in various combustion environments such as laminar flames and internal combustion engines due to its high spatial resolution and sensitivity.As for LⅡmeasurement in aero-engine combustors,however,it normally suffers from very limited optical accesses and often faces mandatory requirements of oblique imaging from a small backward angle.In this work,we demonstrate a Two-Color(2C)LⅡsystem that simultaneously captures LⅡsignal images at two distinct wavelengths using a Scheimpflug imaging configuration.A projective transformation algorithm and image overlapping procedures were employed to spatially correct the raw Scheimpflug LⅡimages.Performance validation of the developed 2C-Scheimpflug LⅡsystem was first conducted under specified conditions in a laminar C_(2)H_(4)/air McKenna flame.The obtained Soot Volume Fraction(SVF)level and its spatial distribution are in consistent with previous studies under identical flame conditions reported by other research groups.Finally,as a demonstration of engineering benchmark application,we applied the developed 2C-Scheimpflug LⅡsystem to measure SVF distribution in the cross-section plane perpendicular to the direction of flame propagation at the exhaust of a single-sector dual-swirl aero-engine model combustor.Transient soot production events were observed and characteristics of the SVF distribution were investigated.These experimental results suggest the feasibility of the 2C-Scheimpflug LⅡtechnique developed in this work for precise and quantitative measurements of soot concentration in practical environments.
文摘Survivin was firstly separated in hybridization of Effector Cell Protease Receptor-1(EPR-1)cDNA in human genome by Yale University's Ambrosini in 1997,which is member of the inhibitor of apoptosis proteins(IAPS).Unlike other IAP protein,found during embryonic and fetal development,survivin wascompletely down-regulated and undetectable in normal adult tissues,and became prominentlyre expressed in all of the most common cancers.It through includes the cysteine/histidine rod-shaped viral IAP repetition sequence baculoviral IAP repeats(BIRs)the structure territory directly or intervenes Caspases the function to display indirectly its anti-perishes weakly the function,simultaneously it also is in the cell division process the chromosome traveler protein(chromosome passenger protein).There are three approaches by which survivin inhibits the processing of apoptosis:(1)inhibits processing of down stream effector caspase-3,caspase-7and caspase-9 in cell receiving apoptotic stimuls;(2)with the Smac/DIABLO function,sends the XIAP activeness to increase,XIAP through directly affects and restrains its function with caspases,achieved restrains function which perishes weakly;(3)through restrains p53 the function to block perishes weakly the process.Survivin expressed specificity and its function multiplicity.Survivin only expresses in tumor tissues and cannot be found in normal terminally differentiated tissues.This kind of expression is been extremely low the cell cycle strict regulation in the G1 time expression,the S time is G1 time 6 times,the G2/M time advances to 40 times,demonstrated its expression has the G2/M time dependence specificity.It has bi-function of inhibiting apoptosis and involving in cell cycle control.Survivin has found in most of tumor cells in recently researches.Survivin expresses generally in all tumor cell line in the American State-run Cancer Research institute anti-tumor medicine screening procedure 60 different tumor cells,in which expresses in the mammary gland cancer cell and the lung cancer cell highly,expresses in the kidney cancer lowly.Survivin except in tumor cell high expression,at breast cancer,tumor in front of and so on endometrium cancer,cervical cancer cancers in the pathological change has the expression.Survivin is over expressed in early malignant,which brokes the balance of proliferation and apoptotic,causes the occurrence of tumor.Obviously,survivin is closely related to the uncontrolled growth carcinogenesis,development and tumorigenesis.Because Survivin in tumor organization's special expression and perishes weakly in the suppression cell and adjusts in the cell division the vital role,causes it to become one to have the latent application value tumor designated object and the tumor treatment new target spot.The recent research of survivin in the development,treatment and situation of tumor is introduced.
文摘In recent years, with the rapid development of large-scale distributed wireless sensor systems and micro-power devices, the disadvantages of traditional chemical battery power supply mode are becoming more and more obvious. Piezoelectric energy collector has attracted wide attention because of its simple structure, no heating, no electromagnetic interference, environmental protection and easy miniaturization. Wind energy is a reproducible resource. Wind energy harvester based on piezoelectric intelligent material can be named piezoelectric wind energy harvesting which converts wind energy into electric power and will have great application prospect. To promote the development of piezoelectric wind energy harvesting technology, research statuses on piezoelectric wind energy harvesting technology are reviewed. The existing problem and development direction about piezoelectric wind energy harvester in the future are discussed. The study will be helpful for researchers engaged in piezoelectric wind energy harvesting.
基金supported by the National Natural Science Foundation of China(Grant No. 51906075)Key Research and Development Program of Department of Science and Technology of Jiangxi Province(Grant No. 20223BBG74009)Science and Technology Innovation Project for Carbon Peak and Carbon Neutrality of Jiangxi Carbon Neutralization Research Center(Grant No. 2022JXST01)。
文摘In the past two decades, the oxy-fuel combustion of pulverized coal has been extensively developed, leading to the completion of several large industrial pilot oxy-fuel plants worldwide. Various types of oxy-fuel burners have been designed and tested in largescale pilot plants as key components of oxy-fuel combustion. These burners face major challenges in terms of their flame stability because of their decreasing stream momentum ratio and increasing carbon dioxide concentration. However, it offers flexibility in adjusting the oxygen concentration in each burner stream. This study aims to provide a comprehensive review of the state-of-the-art knowledge on oxy-coal burner design and operation in power plants. First, the combustion characteristics under oxy-fuel conditions are briefly introduced. Subsequently, the principal requirements and fundamental parameters of the oxy-coal burners are discussed. The development process of oxy-fuel burners is also presented. Moreover, a compatible design strategy and scaling-up techniques are described for oxy-coal burners developed by the authors over the past ten years. The performances of oxy-coal burners in three large pilot oxy-fuel plants worldwide are summarized and compared. Finally, concluding remarks are provided and potential research needs are suggested.
基金The study was supported by the National Natural Science Foundation of China(No.81602773).
文摘Objective:This study was performed to investigate the relationship between the human melanogenesis and antioxidant systems and to further confirm the synergistic effect of oxyresveratrol(OXYR)and resveratrol(RES)in human epidermal melanocyte cell line.Methods:The human epidermal melanocyte line PIG1 cells were divided into the UV groups and control group,treated with different doses of UVB and without UVB,respectively.MTT assay and flow cytometry were used to detect cell viability and apoptosis.The expression of Nrf2/HO-1 and melanogenesis-associated proteins/genes was measured by Western blotting and real-time qPCR(RT-qPCR).pCMV6-XL5-Nrf2 was used to upregulate the expression of Nrf2.Subsequently,the proteins/genes levels of Nrf2/HO-1 and tyrosinase(TYR),melanin/eumelanin content,and reactive oxygen species(ROS)were analyzed.Isobologram analysis and cell experiment were used to analyze whether OXYR and RES inhibit TYR synergistically.Western blotting,RT-qPCR,and NaOH splitting method were used to determine the Nrf2/HO-1 and melanogenesis-associated proteins/genes expression and melanin content to evaluate the efficacy of OXYR and RES.Results:The activated Nrf2 and HO-1 eliminated ROS produced by UVB irradiation.The melanogenesis-associated proteins/genes of melanocyte-inducing transcription factor(MITF,P<0.01 on protein expression),TYR(both P<0.01),TYR-related protein(TRP)-1(both P<0.05),and TRP2(P<0.05 on mRNA expression)were activated in PIG1 cells by UVB irradiation.Simultaneously,the upregulation of Nrf2 significantly reduced melanogenesis formation(P<0.001)and TYR level(P<0.01 on protein expression).Moreover,OXYR and RES synergistically inhibited TYR activity(P<0.001)and reduced melanin content(P<0.001).Conclusions:A microbalance exists between Nrf2/HO-1 signaling and melanogenesis production in the UVBinduced responses of melanocytes.Simultaneously,OXYR enhances the ability of RES to inhibit melanin production.
文摘Over a century ago,the first clinical and neuropathological insights into major neurodegenerative diseases began to emerge:the description of Alzheimer’s disease(AD)by Alois Alzheimer in 1906,frontotemporal dementia by Arnold Pick in the same years,and Lewy bodies by Friedrich Lewy in 1912.These foundational studies laid the groundwork for the classification of what we now recognize as distinct neurodegenerative entities(Allali,2024).
基金Funded by the China Building Material Federation Projects(Nos.20221JBGS06-19 and 2023JBGS02-01)。
文摘The substitution of TiO_(2)for SiO_(2)in Y_(2)O_(3)-Li_(2)O-Al_(2)O_(3)-SiO_(2)(YLAS)glass-ceramics significantly altered their crystallization behavior and properties.Introducing TiO_(2)reduced the glass transition temperature while increasing the crystallization peak temperature and lowering activation energy,which facilitated crystallization.The crystal growth shifted from three-dimensional to two-dimensional,and the primary phases transitioned from Al_(9.83)Zr_(0.17)and Y_(2)Si_(2)O_(7)to Y_(4.67)(SiO_(4))_(3)O,though crystal morphology remained unchanged.Grain size increased with higher crystallization temperatures.Mechanically,Vickers hardness slightly decreased(from 796 to 784 Hv),while bending strength improved(from 141 to 146 MPa),suggesting that TiO_(2)enhanced toughness without compromising structural integrity.The strength of the glass can be further improved through two-step ion exchange,but excessive crystallization can lead to cracks on the glass surface due to excessive surface compressive stress,resulting in a decrease in bending strength.These findings provide critical insights for optimizing YLAS glass-ceramics for advanced applications.
