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基于Deeplabv3+和LK光流的动态视觉SLAM算法 被引量:1
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作者 周若轩 张瑞乾 +2 位作者 陈勇 袁旭浩 秦慧军 《电子测量技术》 北大核心 2025年第9期149-155,共7页
传统ORB-SLAM3系统在静态环境中表现优秀,但存在动态特征时会引入不必要的噪声,造成特征匹配出现错误,而现有动态SLAM算法难以完整判断潜在动态特征,出现漏检或误检导致定位精度下降。针对这些问题,将语义分割网络Deeplabv3+与LK光流法... 传统ORB-SLAM3系统在静态环境中表现优秀,但存在动态特征时会引入不必要的噪声,造成特征匹配出现错误,而现有动态SLAM算法难以完整判断潜在动态特征,出现漏检或误检导致定位精度下降。针对这些问题,将语义分割网络Deeplabv3+与LK光流法融合进ORB-SLAM3的跟踪线程,首先将Deeplabv3+的主干网络替换为Mobilenetv3,提高语义分割的精度,然后使用语义分割获取潜在动态目标掩码,初步滤除动态特征点,对剩余特征点进行LK光流计算,将光流平均误差作为阈值防止剩余静态特征点过少导致位姿估计失败。相比于原ORB-SLAM3,本文改进的算法在TUM高动态序列的定位精度平均提升了47.92%,与现有优秀动态SLAM算法相比,本文算法在TUM数据集的Walking_static序列取得了最高的定位精度。 展开更多
关键词 同时定位与地图构建 动态环境 语义分割 光流法
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An Overview of EMI Research in Flyback Converters
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作者 YAO Juntao WANG Shuo 《电源学报》 北大核心 2025年第7期1-16,共16页
Flyback converters in consumer and commercial products must adhere to strict regulatory standards for conducted and radiated electromagnetic interference(EMI).Managing EMI has become increasingly complex in mod-ern po... Flyback converters in consumer and commercial products must adhere to strict regulatory standards for conducted and radiated electromagnetic interference(EMI).Managing EMI has become increasingly complex in mod-ern power electronics,particularly with the integration of high-speed wide bandgap(WBG)devices into compact sys-tem layouts.A review of established modeling techniques and mitigation strategies for conducted EMI is presented,fo-cusing on differential mode(DM)and common mode(CM)noise,alongside radiated EMI in flyback converters.The discussion encompasses solutions at both component-level design and converter system optimization. 展开更多
关键词 FLYBACK EMI conducted EMI radiated EMI differential mode(DM) common mode(CM)
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Exploring a novel approach to assessing surgical team collaboration:Evidence of brain activity synchronization
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作者 Shuyi(Kiana)Wang Ghazal Hashemi +1 位作者 Yao Zhang Bin Zheng 《Laparoscopic, Endoscopic and Robotic Surgery》 2025年第1期6-12,共7页
Objective:Interpersonal brain synchronization(IBS)has emerged as a significant concept in understanding collaborative team dynamics,with functional near-infrared spectroscopy(fNIRS)proving to be a vital tool in its as... Objective:Interpersonal brain synchronization(IBS)has emerged as a significant concept in understanding collaborative team dynamics,with functional near-infrared spectroscopy(fNIRS)proving to be a vital tool in its assessment.This review aims to collate and analyze the literature on the application of fNIRS in various team settings,emphasizing its potential utility in surgical environments.Methods:A thorough search and screening process across multiple databases resulted in 17 studies being reviewed,with a focus on the utilization of fNIRS to measure IBS in different collaborative tasks.This review examined the tasks employed,participant demographics,organizational structures of teams,methodologies for IBS measurement,and correlations between brain synchronization and behavioral measurements.Results:fNIRS emerged as a non-invasive,cost-effective,and portable tool,predominantly used to assess IBS in pair-based tasks with a variety of participant demographics.Wavelet transform coherence was the primary method used for measuring synchronization,particularly in the prefrontal brain region.A consistent correlation was found between increased brain synchronization and enhanced team performance,underscoring the potential of fNIRS in understanding and optimizing team dynamics.Conclusion:This review establishes fNIRS as a promising tool for investigating the neural mechanisms underlying team cooperation,providing invaluable insights for potential applications in surgical settings.While acknowledging the limitations in the current literature,the review highlights the need for further research with larger sample sizes and varied task complexities to solidify the understanding of IBS and its impact on team performance.The ultimate goal is to leverage fNIRS in assessing and improving surgical team dynamics,contributing to improved patient outcomes and safety. 展开更多
关键词 Functional near-infrared spectroscopy Interpersonal brain synchronization Team cognition Team performance Surgical team training
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污泥气化渣包覆骨料混凝土单轴抗压性能与破坏模拟
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作者 马军涛 薛佳熔 +2 位作者 谭云飞 宋泽瑢 赵顺波 《建筑材料学报》 北大核心 2026年第1期77-86,共10页
采用水泥-粉煤灰复合体系对污泥气化渣进行包覆处理,将其用作轻骨料混凝土的粗骨料,系统研究了粗骨料类型及体积分数对混凝土性能的影响。建立了混凝土二维有限元模型,模拟单轴受压条件下混凝土破坏时的损伤分布及应力-应变曲线。结果表... 采用水泥-粉煤灰复合体系对污泥气化渣进行包覆处理,将其用作轻骨料混凝土的粗骨料,系统研究了粗骨料类型及体积分数对混凝土性能的影响。建立了混凝土二维有限元模型,模拟单轴受压条件下混凝土破坏时的损伤分布及应力-应变曲线。结果表明:经水泥-粉煤灰复合体系包覆后,污泥气化渣在保留轻质特性的同时筒压强度由2.5 MPa显著提升至6.1 MPa;当粗骨料体积分数为40%时,污泥气化渣包覆骨料混凝土的损伤区域最小,抗压性能最优。 展开更多
关键词 污泥气化渣包覆骨料 骨料强化 轻骨料混凝土 单轴受压 破坏模拟
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耐心资本与体育企业韧性——基于一个倒U型模型的实证检验
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作者 谭宏 刘青 《武汉体育学院学报》 北大核心 2026年第3期42-53,共12页
耐心资本在体育企业韧性塑造中具有延迟收益、维持稳态与支撑创新的独特功能。基于2015-2023年中国A股体育上市企业数据,运用面板回归与非线性模型,系统探讨耐心资本对体育企业韧性的影响特征及其管理层长期认知的作用机制,并考察国家... 耐心资本在体育企业韧性塑造中具有延迟收益、维持稳态与支撑创新的独特功能。基于2015-2023年中国A股体育上市企业数据,运用面板回归与非线性模型,系统探讨耐心资本对体育企业韧性的影响特征及其管理层长期认知的作用机制,并考察国家体育产业示范基地、大型体育赛事、全球公共卫生事件、国家体育消费试点城市与战略导向的情境调节效应。研究发现:(1)耐心资本与体育企业韧性呈显著倒U型关系,适度耐心资本可增强企业抗风险与创新能力,过量则导致资源沉淀与僵化;(2)机制分析表明,适度耐心资本通过强化管理层长期认知,提升企业战略稳健性与组织学习力,进而促进韧性提升;(3)调节效应检验表明,不同情境下耐心资本效应存在曲线位移:体育产业示范基地样本及大型体育赛事、全球公共卫生事件、国家体育消费试点城市样本中曲线右移;战略导向差异导致利润导向型与增长导向型企业拓宽了耐心资本的有效区间,增强了韧性。研究结论揭示了耐心资本在体育产业中影响企业韧性的非线性规律,为优化资本结构、强化管理认知与增强抗风险能力提供了实证支撑与政策启示。 展开更多
关键词 体育企业韧性 耐心资本 管理层认知 倒U型模型
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Practical recommendations on stretching exercise:A Delphi consensus statement of international research experts
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作者 Konstantin Warneke Ewan Thomas +17 位作者 Anthony J.Blazevich José Afonso David G.Behm Paulo H.Marchetti Gabriel S.Trajano Masatoshi Nakamura Francisco Ayala Stefano Longo Nicolas Babault Sandro R.Freitas Pablo B.Costa Andreas Konrad Antoine Nordez Arnold Nelson Astrid Zech Anthony D.Kay Olyvia Dontit Jan Wilke 《Journal of Sport and Health Science》 2025年第5期110-123,共14页
Background:Stretching has wide appeal,but there seems to exist some mismatch between its purported applications and what the evidence shows.There is compelling evidence for some stretching applications,but for others,... Background:Stretching has wide appeal,but there seems to exist some mismatch between its purported applications and what the evidence shows.There is compelling evidence for some stretching applications,but for others,the evidence seems heterogeneous or unsupportive.The discrepancies even affect some systematic reviews,possibly due to heterogeneous eligibility criteria and search strategies.This consensus paper seeks to unify the divergent findings on stretching and its implications for both athletic performance and clinical practices by delivering evidence-based recommendations.Methods:A panel of 20 experts with a blend of practical experience and scholarly knowledge was assembled.The panel meticulously reviewed existing systematic reviews,defined key terminologies(e.g.,consensus definitions for different stretching modes),and crafted guidelines using a Delphi consensus approach(minimum required agreement:80%).The analysis focused on 8 topics,including stretching's acute and chronic(long-term)effects on range of motion,strength performance,muscle hypertrophy,stiffness,injury prevention,muscle recovery,posture correction,and cardiovascular health.Results:There was consensus that chronic and acute stretching(a)improves range of motion(although alternatives exist)and(b)reduces muscle stiffness(which may not always be desirable);the panel also agreed that chronic stretching(c)may promote vascular health,but more research is warranted.In contrast,consensus was found that stretch training does not(a)contribute substantively to muscle growth,(b)serve as an allencompassing injury prevention strategy,(c)improve posture,or(d)acutely enhance post-exercise recovery.Conclusion:These recommendations provide guidance for athletes and practitioners,highlighting research gaps that should be addressed to more comprehensively understand the full scope of stretching effects. 展开更多
关键词 Range of motion Strength Movement preparation Recovery Evidence-based practice STRETCH
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面向新财经人才培养目标的营销专业产教融合模式实践探索
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作者 耿立沙 王胜洲 梁晓东 《河北经贸大学学报(综合版)》 2026年第1期90-95,共6页
在新文科教育改革的背景下,“新财经”是高等财经教育改革的重要实践形态,新财经人才培养是应对技术迭代与产业升级的必然选择。新财经人才培养应以“为党育人、为国育才”为根本导向,以产教融合为纽带,聚焦数字经济、人工智能等技术革... 在新文科教育改革的背景下,“新财经”是高等财经教育改革的重要实践形态,新财经人才培养是应对技术迭代与产业升级的必然选择。新财经人才培养应以“为党育人、为国育才”为根本导向,以产教融合为纽带,聚焦数字经济、人工智能等技术革命,实现教育链、人才链、产业链与创新链的深度融合。营销专业作为一个实践性、应用性极强的专业,产教融合在其人才培养中具备了必要性和可能性,但其在产教融合中也存在培养目标与实际需求脱节、产教融而不合、课程资源缺乏实用性及师资队伍结构不合理等问题。需求导向、协同创新的设计路径应包括:立足产业需求,结合学科特色、地域优势等对培养目标进行差异化定位;完善双元协同三融合的教学平台;重构模块化课程体系;完善双师协同育人体系,以期实现营销专业人才培养的高质量发展。 展开更多
关键词 新财经人才培养 人工智能 营销专业 产教融合
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大流动性钢纤维橡胶混凝土力学及抗冲击性能研究
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作者 徐诺军 陈永升 +2 位作者 李煜晓 丁新新 曲福来 《华北水利水电大学学报(自然科学版)》 北大核心 2026年第2期96-102,160,共8页
【目的】分析钢纤维和橡胶颗粒对大流动性混凝土力学性能、抗冲击能耗、延性比和韧性系数的影响,并对大流动性混凝土力学和抗冲击性能进行改善。【方法】设计不同钢纤维掺量(0.8%、1.2%和1.6%)和橡胶颗粒体积替代率(10%、15%和20%)的钢... 【目的】分析钢纤维和橡胶颗粒对大流动性混凝土力学性能、抗冲击能耗、延性比和韧性系数的影响,并对大流动性混凝土力学和抗冲击性能进行改善。【方法】设计不同钢纤维掺量(0.8%、1.2%和1.6%)和橡胶颗粒体积替代率(10%、15%和20%)的钢纤维橡胶混凝土试件,对其进行冲击落锤试验以及基本力学性能试验,采用两参数Weibull函数模型对大流动性钢纤维橡胶混凝土抗冲击寿命进行预测。【结果】(1)钢纤维可以提高大流动性混凝土的立方体抗压强度和劈裂抗拉强度,橡胶颗粒的掺入降低了混凝土的强度;(2)钢纤维可以显著提高大流动性混凝土的抗冲击性能,橡胶颗粒体积替代率为20%、钢纤维掺量为1.6%的混凝土终裂冲击次数最多,表现出最佳的抗冲击性能;(3)在钢纤维掺量不变的条件下,大流动性橡胶混凝土抗冲击延性比和韧性系数随橡胶颗粒替代率的提高而增加。【结论】钢纤维和橡胶颗粒对大流动性混凝土力学性能影响不同,但均可以显著提高大流动性混凝土的抗冲击性能,大流动性钢纤维橡胶混凝土的抗冲击寿命符合Weibull分布模型。该研究成果可为大流动性钢纤维橡胶混凝土抗冲击性能的评价提供参考。 展开更多
关键词 大流动性 钢纤维 橡胶颗粒 混凝土 抗冲击性能 WEIBULL分布
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The Promoting Angiogenesis and Its Clinical Significance of CD33^(+)Myeloid Derived Suppressor Cells Derived From Small Cell Lung Cancer
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作者 Heran Cui Jingjing Liu +4 位作者 Peiyan Zhao Yan Liu Shaowei Lan Xueli Jiang Hui Li 《Chronic Diseases and Translational Medicine》 2026年第1期49-62,共14页
Background:Myeloid-derived suppressor cells(MDSCs)are important tumor microenvironment components in small cell lung cancer(SCLC).We successfully identified MDSCs expressing the surface marker CD33 in SCLC;nonetheless... Background:Myeloid-derived suppressor cells(MDSCs)are important tumor microenvironment components in small cell lung cancer(SCLC).We successfully identified MDSCs expressing the surface marker CD33 in SCLC;nonetheless,whether CD33^(+)MDSCs promote SCLC angiogenesis remains unclear.This study aims to explore the angiogenic effect and clinical significance of CD33^(+)MDSCs derived from SCLC.Method:Nineteen patients diagnosed with extensive-stage SCLC at Jilin Cancer Hospital were selected as the research subjects.CD33^(+)MDSCs were isolated from the peripheral blood of patients with SCLC using magnetic bead separation and CD33 expression was detected by flow cytometry.The angiogenic potential of CD33^(+)MDSCs derived from the peripheral blood of patients with SCLC and healthy individuals was assessed using human umbilical vein endothelial cell(HUVEC)angiogenesis assays,and the clinical significance of CD33^(+)MDSCs in promoting angiogenesis in patients with SCLC was analyzed using clinical data.Results:Compared to healthy individuals,the CD33^(+)MDSCs(CD14^(+)CD33^(+))isolated from the peripheral blood of SCLC patients exhibited a greater ability to promote HUVEC tubular growth(average vessel length:57.60 mm[47.78 mm]vs.39.07 mm[15.84 mm],p=0.000;vessel area:371,890 mm^(3)[699,927 mm^(3)]vs.334,652 mm^(3)[219,520 mm^(3)],p<0.000;total number of junctions:141[301]vs.120[94],p<0.005),and their angiogenic ability was associated with older age,female sex,high performance status scores,no systematic treatment,and treatment unresponsiveness(p<0.050).Furthermore,the enhanced angiogenic ability of CD33^(+)MDSCs may represent a risk factor for treatment unresponsiveness(average vessel length:Odds ratio=3.904,95%CI=1.812-8.409,p=0.001;vessel area:Odds ratio=2.501,95%CI=1.187-5.267,p=0.016;total number of junctions:Odds ratio=3.630,95%CI=1.686-7.815,p=0.001)and is associated with a poor SCLC prognosis(average vessel length:Hazard ratio=2.210,95%CI=1.299-3.758,p=0.003;vessel area:Hazard ratio=2.170,95%CI=1.274-3.693,p=0.004;total number of junctions:Hazard ratio=2.267,95%CI=1.333-3.853,p=0.003).Conclusion:CD33^(+)MDSCs derived from the peripheral blood of patients with SCLC promote angiogenesis,which is a risk factor for treatment unresponsiveness and is associated with poor prognosis. 展开更多
关键词 ANGIOGENESIS myeloid derived suppressor cells PROGNOSIS small cell lung cancer therapeutic effect
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Nanotechnology in plant tissue culture:a review
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作者 Sabreena Jan Nayeema Jan +2 位作者 Seema Singh Muhammad Ashraf Shah Irshad Ahmad Bhat 《Horticultural Plant Journal》 2026年第2期237-256,共20页
Plant tissue culture represents an advanced biotechnological technique for propagating and conserving threatened plant species efficiently.This method enables the rapid production of genetically identical plants under... Plant tissue culture represents an advanced biotechnological technique for propagating and conserving threatened plant species efficiently.This method enables the rapid production of genetically identical plants under controlled sterile laboratory conditions(in vitro).Its applications span forestry,horticulture,and,crucially,plant breeding.Nanoparticles have emerged as innovative tools to address limitations in conventional plant tissue culture,offering diverse functionalities based on their unique physicochemical properties.This review focuses on the utilization of nanotechnology in enhancing various aspects of plant tissue culture.Nanoparticles,such as silver and zinc oxide,have demonstrated significant roles as antimicrobial agents and anti-browning agents.They also serve as elicitors,stimulating callus proliferation,root elongation,rapid shoot formation,and the enhanced production of bioactive compounds on a large scale.Furthermore,nanoparticles contribute to mitigating oxidative stress within cells,thereby promoting increased callus formation,elongated roots,and elevated production of secondary metabolites.Their influence extends to somaclonal variation and genetic transformation processes within plant tissue culture.These contributions collectively underscore the potential of nanoparticles to foster more efficient,sustainable,and scalable biotechnological solutions in in vitro culture.The implications extend to reducing resource dependency and mitigating environmental impacts,positioning nanotechnology as a transformative approach in sustainable plant biotechnology. 展开更多
关键词 CALLUS ELICITORS Invitro MICROPROPAGATION NANOPARTICLES Secondary metabolites
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OSCJC:An open-set compound jamming cognition method for radar systems in high-intensity electromagnetic warfare
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作者 Kaixiang Zhang Jiaxiang Zhang +3 位作者 Xinrui Han Yilin Wang Bo Wang Quanhua Liu 《Defence Technology(防务技术)》 2026年第1期436-455,共20页
In high-intensity electromagnetic warfare,radar systems are persistently subjected to multi-jammer attacks,including potentially novel unknown jamming types that may emerge exclusively under wartime conditions.These j... In high-intensity electromagnetic warfare,radar systems are persistently subjected to multi-jammer attacks,including potentially novel unknown jamming types that may emerge exclusively under wartime conditions.These jamming signals severely degrade radar detection performance.Precise recognition of these unknown and compound jamming signals is critical to enhancing the anti-jamming capabilities and overall reliability of radar systems.To address this challenge,this article proposes a novel open-set compound jamming cognition(OSCJC)method.The proposed method employs a detection-classification dual-network architecture,which not only overcomes the false alarm and misdetection issues of traditional closed-set recognition methods when dealing with unknown jamming but also effectively addresses the performance bottleneck of existing open-set recognition techniques focusing on single jamming scenarios in compound jamming environments.To achieve unknown jamming detection,we first employ a consistency labeling strategy to train the detection network using diverse known jamming samples.This strategy enables the network to acquire highly generalizable jamming features,thereby accurately localizing candidate regions for individual jamming components within compound jamming.Subsequently,we introduce contrastive learning to optimize the classification network,significantly enhancing both intra-class clustering and inter-class separability in the jamming feature space.This method not only improves the recognition accuracy of the classification network for known jamming types but also enhances its sensitivity to unknown jamming types.Simulations and experimental data are used to verify the effectiveness of the proposed OSCJC method.Compared with the state-of-the-art open-set recognition methods,the proposed method demonstrates superior recognition accuracy and enhanced environmental adaptability. 展开更多
关键词 Radar compound jamming cognition Open-set recognition Detection-classification dual-network Time-frequency analysis Contrastive learning
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The architecture of petal-shaped CoS/CuS nanosphere materials for high-performance magnesium-ion battery cathode materials
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作者 Runjing Xu Yuan Fang +10 位作者 Xin Gao Han Xiao Zhiyuan Zhang Jiayun Zhang Huinan Yu Jiafeng Ruan Fengmei Wang Xinjie Li Ya Chen Xiaodong Chen Lifeng Cui 《Green Energy & Environment》 2026年第1期169-180,共12页
Rechargeable magnesium batteries(RMBs)possess the merits of greater theoretical capacity,cheaper magnesium metal and not easily producing branched crystals,and greater safety.Therefore,the current researches mainly co... Rechargeable magnesium batteries(RMBs)possess the merits of greater theoretical capacity,cheaper magnesium metal and not easily producing branched crystals,and greater safety.Therefore,the current researches mainly concentrate on the exploration of high-performance RMBs in the initial stage,but still face many gigantic challenges.Herein,petal-shaped nanorods CoS/CuS materials are successfully synthesized as RMBs cathode materials through a two-step metal sulfide template-free solvent-thermal synthesis method,which can effectively improve the reaction kinetics due to the petal-like nano-structure and provide rich electrochemically active sites to decrease the transport barrier of Mg^(2+),thus contributing to the enhancement of the reaction kinetics of magnesium storage in RMBs.The electrochemical performance test illustrates that CoS/CuS composite nanomaterials can considerably improve the charging and discharging specific capacity of the batteries as well as the voltage of the batteries due to the existing synergistic effect between them.The specific capacity of CoS/CuS cathode still can still be maintained as high as 62.8 mAh g^(−1)after 300 cycles at 200 mA g^(−1).And the specific capacity of this electrode material changes from 180.6 mAh g^(−1)to 30 mAh g^(−1)at the current densities from 100 mA g^(−1)to 1000 mA g^(−1),and when the current density is restored to 100 mA g^(−1),the specific capacity gradually recovered to 178.6 mAh g^(−1),which showed better rate performance and ultra-high cycling stability.This work highlights how the introduction of CuS into CoS nanostructures can benefit the reversibility and cyclicity of the magnesium storage reaction and offers an original and practical route for the modification of RMBs electrode materials with good electrochemical properties. 展开更多
关键词 Rechargeable magnesium batteries Electrochemical performance CoS/CuS cathode Petal-shaped nanostructure
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超高性能钢壳混凝土连续刚构桥优化设计
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作者 刘世明 张威 +3 位作者 陈平祥 朱昌奎 吕亚辉 孙宝珊 《华北水利水电大学学报(自然科学版)》 北大核心 2026年第1期105-113,122,共10页
【目的】针对大跨径预应力混凝土连续刚构桥存在的跨中下挠、腹板开裂及跨径突破等技术难题,以主跨120 m的后峪沟大桥为研究对象,提出一种新型超高性能钢壳混凝土结构,并对此结构进行优化设计研究。【方法】采用Midas Civil桥梁专用有... 【目的】针对大跨径预应力混凝土连续刚构桥存在的跨中下挠、腹板开裂及跨径突破等技术难题,以主跨120 m的后峪沟大桥为研究对象,提出一种新型超高性能钢壳混凝土结构,并对此结构进行优化设计研究。【方法】采用Midas Civil桥梁专用有限元分析软件,基于超高性能钢壳混凝土材料的力学特性,分析超高性能钢壳混凝土连续刚构桥的边中跨比、箱梁及桥墩截面构造,并进行技术经济性评估。研究重点包括合理的边中跨比范围、桥墩梁高和底板厚度优化设计,并包括结构静力响应和整桥稳定性分析。【结果】①超高性能钢壳混凝土箱梁的合理边中跨比为0.475~0.550,主桥中墩支点处梁高与跨中梁高的比值为1.22~2.22。②超高性能钢壳混凝土桥梁在结构自重和碳排放方面表现出显著优势,箱梁和桥墩的自重分别减少了59.5%和63.6%,碳排放量分别减少了54.9%和29.1%。③桥墩造价增加了8.3%,箱梁造价减少了27.9%。【结论】超高性能钢壳混凝土连续刚构桥在自重、造价和碳排放方面具有显著优势,经优化设计后满足强度和刚度要求。与传统预应力混凝土桥梁相比,超高性能钢壳混凝土桥梁具有更好的经济性和环境效益,适用于大跨径连续刚构桥的设计和应用,具备较高的工程实践价值。 展开更多
关键词 箱梁 连续刚构桥 超高性能钢壳混凝土 优化设计 静力验算 稳定性分析
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基于网络药理学与实验探讨芪参益气滴丸干预低氧性肺动脉高压的作用机制
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作者 黄凯 张璞 +2 位作者 华玉美多 顾存林 李占强 《中国高原医学与生物学杂志》 2026年第1期1-11,共11页
目的探讨芪参益气滴丸(QSYQ)干预低氧性肺动脉高压(HPH)的作用机制。方法基于网络药理学与实验探讨QSYQ干预HPH的作用机制。结果网络药理学研究显示,获得经QSYQ干预HPH的靶点共131个,进一步筛选得到TP53、PTGS2、BCL-2等41个核心靶点。... 目的探讨芪参益气滴丸(QSYQ)干预低氧性肺动脉高压(HPH)的作用机制。方法基于网络药理学与实验探讨QSYQ干预HPH的作用机制。结果网络药理学研究显示,获得经QSYQ干预HPH的靶点共131个,进一步筛选得到TP53、PTGS2、BCL-2等41个核心靶点。细胞实验研究显示,IC_(50)为1475μg/mL。EdU染色结果显示,与常氧对照组相比,低氧模型组的PASMCs增殖增强;与低氧模型组相比,QSYQ抑制了低氧诱导的增殖且呈剂量依赖性;与QSYQ高剂量组相比,高剂量QSYQ与TP53抑制剂PFTα联合给药时,EdU阳性细胞数较QSYQ高剂量组回升。TUNEL染色结果显示,低氧模型组的PASMCs凋亡水平减弱,QSYQ促进了细胞凋亡水平;与QSYQ高剂量组相比,高剂量QSYQ与TP53抑制剂PFTα联合给药时,凋亡细胞数量较QSYQ高剂量组减少。Western Blot结果显示,低氧降低肺动脉平滑肌细胞中促凋亡蛋白TP53、Bax的表达水平,同时提升抗凋亡蛋白Bcl-2及细胞增殖关键调控蛋白CyclinD1、CDK4的表达。经QSYQ干预后,上述异常表达均得到有效逆转:TP53与Bax表达回升,Bcl-2、CyclinD1和CDK4表达下降。当联合使用TP53抑制剂PFTα时,QSYQ对TP53、Bax的上调作用及Bcl-2的下调作用被部分阻断,但对CyclinD1和CDK4的抑制作用未受任何影响。结论QSYQ通过双重机制协同改善HPH:一方面,通过激活TP53信号通路,上调Bax/Bcl-2,启动线粒体凋亡途径,从而促进PASMCs凋亡;另一方面,独立于TP53通路,下调CyclinD1/CDK4蛋白复合物水平,阻滞细胞周期(G1/S期)的转换,从而抑制PASMCs异常增殖。 展开更多
关键词 芪参益气滴丸 低氧 肺动脉平滑肌细胞 TP53 细胞 增殖 凋亡
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Shaping the future of biofabrication and biomanufacturing in Singapore
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作者 Wei Long Ng Marin Zhen Lin Yee +16 位作者 Kee Woei Ng Yanjiao Teng Seeram Ramakrishna Yanting Liu Swee Leong Sing Sharon Mui Ling Nai Kun Liang Hong Liang Tey Adrian Kee Keong Teo Andri K.Riau Jodhbir S.Mehta Jia Min Lee Xi Huang Wai Yee Yeong Boyang Huang Cian Vyas Paulo Bartolo 《Bio-Design and Manufacturing》 2026年第2期206-239,I0002,I0003,共36页
Biofabrication and biomanufacturing are rapidly transforming how materials,therapeutics,and functional biological constructs are produced.These fields integrate developments in sustainable biomaterials,precision fabri... Biofabrication and biomanufacturing are rapidly transforming how materials,therapeutics,and functional biological constructs are produced.These fields integrate developments in sustainable biomaterials,precision fabrication,biological systems,and data-driven engineering to produce scalable,efficient,and environmentally aligned production pathways.This review highlights recent scientific advances led by researchers in Singapore,focusing on three interconnected pillars:sustainable bio derived materials,enabling fabrication and manufacturing technologies,and emerging applications.We first examine the expanding use of biomass-derived feedstocks,including human hair keratin,aquaculture side-streams,and plant-derived polysaccharides,which support circular and resource-conscious material development.We then present advances in biofabrication technologies,including electrospinning,three-dimensional bioprinting,and metal additive manufacturing,that enable improved control over the structure,function,and manufacturability of biomedical and functional constructs.Emerging applications,such as machine learning-assisted additive manufacturing,food biomanufacturing,regenerative cell therapy,microneedles,and bioelectronics,exemplify how biofabrication and biomanufacturing are increasingly interrelated across the health,materials,and technological domains.These research contributions from Singapore exemplify how sustainable feedstocks,digital and automated fabrication platforms,and biologically driven applications are shaping the evolving landscape of biofabrication and biomanufacturing.The convergence of materials science,biological engineering,and advanced manufacturing continues to enable new opportunities for innovation in biomedical,industrial,and societal contexts. 展开更多
关键词 3D bioprinting BIOFABRICATION Sustainable biomaterials Food biomanufacturing Cell therapy MICRONEEDLES BIOELECTRONICS
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Designing and Evaluating a Collaborative Knowledge Management Framework for Leaf Disease Detection
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作者 Komal Bashir Mariam Rehman +1 位作者 Afnan Bashir Faria Kanwal 《Computer Systems Science & Engineering》 SCIE EI 2022年第8期751-777,共27页
Knowledge Management(KM)has become a dynamic concept for inquiry in research.The management of knowledge from multiple sources requires a systematic approach that can facilitate capturing all important aspects related... Knowledge Management(KM)has become a dynamic concept for inquiry in research.The management of knowledge from multiple sources requires a systematic approach that can facilitate capturing all important aspects related to a particular discipline,several KM frameworks have been designed to serve this purpose.This research aims to propose a Collaborative Knowledge Management(CKM)Framework that bridges gaps and overcomes weaknesses in existing frameworks.The paper also validates the framework by evaluating its effectiveness for the agriculture sector of Pakistan.A software LCWU aKMS was developed which serves as a practical implementation of the concepts behind the proposed CKMF framework.LCWU aKMS served as an effective system for rice leaf disease detection and identification.It aimed to enhance CKM through knowledge sharing,lessons learned,feedback on problem resolutions,help from co-workers,collaboration,and helping communities.Data were collected from 300 rice crop farmers by questionnaires based on hypotheses.Jennex Olfman model was used to estimate the effectiveness of CKMF.Various tests were performed including frequency measures of variables,Cronbach’s alpha reliability,and Pearson’s correlation.The research provided a KMS depicting KM and collaborative features.The disease detection module was evaluated using the precision and recall method and found to be 94.16%accurate.The system could replace the work of extension agents,making it a cost and time-effective initiative for farmer betterment. 展开更多
关键词 Collaborative knowledge management FRAMEWORK jennex olfman km success model knowledge management rice disease detection
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Biosynthesis of Bioadaptive Materials:A Review on Developing Materials Available for Tissue Adaptation
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作者 Junxuan Ma Zhiyu Zhou +4 位作者 Manman Gao Binsheng Yu Deming Xiao Xuenong Zou Cody Bvnger 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2016年第9期810-814,共5页
Biomaterials are increasingly being evolved to actively adapt to the desired microenvironments so as to introduce tissue integration, reconstruct stability, promote regeneration, and avoid immune rejection. The comple... Biomaterials are increasingly being evolved to actively adapt to the desired microenvironments so as to introduce tissue integration, reconstruct stability, promote regeneration, and avoid immune rejection. The complexity of its mechanisms poses great challenge to current biomimetic synthetic materials. Although still at initial stage, harnessing cells, tissues, or even entire body to synthesize bioadaptive materials is introducing a promising future. 展开更多
关键词 Biomaterials Bioadaptation Tissue integration Biosynthesis
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茯苓多糖的结构、活性及其构效关系研究进展 被引量:23
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作者 厉晓 龚婕 +5 位作者 丁婵 彭思源 浦子牛 熊文惠 李顺祥 崔培梧 《中草药》 北大核心 2025年第1期305-317,共13页
茯苓多糖是茯苓菌核、菌丝体及发酵液的主要活性物质之一,具有免疫调节、抗肿瘤、抗炎、抗氧化、抗抑郁、保肝健胃、提高记忆力及镇静催眠等活性,但其构效关系一直未得到充分解析,且茯苓菌核不同部位和通过不同培养工艺合成的茯苓多糖... 茯苓多糖是茯苓菌核、菌丝体及发酵液的主要活性物质之一,具有免疫调节、抗肿瘤、抗炎、抗氧化、抗抑郁、保肝健胃、提高记忆力及镇静催眠等活性,但其构效关系一直未得到充分解析,且茯苓菌核不同部位和通过不同培养工艺合成的茯苓多糖结构也普遍存在差异,因此仅依赖经典的总多糖含量分析方法无法实现对茯苓多糖结构和活性的客观评价,有必要开展有关茯苓多糖的构效关系探索,并建立可实现对茯苓多糖进行定性、定量分析的系统评价方法,助力茯苓多糖的科学应用与开发。基于此,对茯苓多糖的结构、生物活性进行系统综述,在此基础上探讨其构效关系,为茯苓多糖的科学分析、结构修饰、生物合成及综合开发提供参考。 展开更多
关键词 茯苓多糖 结构表征 结构修饰 生物活性 构效关系 免疫调节 抗肿瘤 抗抑郁 镇静催眠
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基于HPLC指纹图谱和多成分定量结合化学模式识别的白薇质量评价 被引量:2
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作者 龚婕 姚芙 +5 位作者 厉晓 丁婵 彭思源 熊文惠 浦子牛 崔培梧 《中草药》 北大核心 2025年第15期5578-5585,共8页
目的建立白薇Cynanchi Atrati Radix高效液相色谱(high performance liquid chromatography,HPLC)指纹图谱和多成分含量测定方法,结合化学模式识别评价其质量。方法采用Waters-Symmetry-C_(18)(250 mm(4.6 mm,5μm))色谱柱,以乙腈-0.1%... 目的建立白薇Cynanchi Atrati Radix高效液相色谱(high performance liquid chromatography,HPLC)指纹图谱和多成分含量测定方法,结合化学模式识别评价其质量。方法采用Waters-Symmetry-C_(18)(250 mm(4.6 mm,5μm))色谱柱,以乙腈-0.1%磷酸水为流动相梯度洗脱,体积流量为1.0 mL/min,柱温为25℃,进样量为20μL,采集波长为270、310 nm。通过中药指纹图谱相似度分析软件及化学模式识别对26批白薇饮片进行分析,并同时采用外标法测定其中尿苷、对羟基苯乙酮和2,4-二羟基苯乙酮含量。结果26批白薇饮片指纹图谱标定了14个共有峰,确认了其中3个共有峰,分别为尿苷(5号峰)、对羟基苯乙酮(9号峰)、2,4-二羟基苯乙酮(12号峰),相似度为0.626~1.000;依据聚类分析(cluster analysis,CA)、主成分分析(principal component analysis,PCA)和偏最小二乘法-判别分析(partial least squares-discriminant analysis,OPLS-DA)结果可将26批白薇饮片分为2大类,筛选出4个主成分,累积贡献率80.652%。白薇饮片中尿苷、对羟基苯乙酮和2,4-二羟基苯乙酮质量分数分别为0.14~0.29、1.74~2.74、0.25~0.49 mg/g。结论建立的白薇HPLC指纹图谱分析操作简单、结果可靠,为白薇资源及其相关产品的品质评价提供了依据。 展开更多
关键词 白薇 指纹图谱 含量测定 尿苷 对羟基苯乙酮 2 4-二羟基苯乙酮 质量评价
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纯铜靶材的微观结构调控与成膜特性 被引量:1
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作者 彭海 陈天天 +4 位作者 闻明 沈月 巢云秀 施晨琦 王传军 《机械工程材料》 北大核心 2025年第6期43-51,共9页
采用真空感应熔炼、均匀化退火、锻造、温轧和退火工艺制备纯铜靶材,研究了温轧态和不同温度(400,500,600,700℃)退火态纯铜靶材的微观结构;利用微观结构最优的退火态纯铜靶材和温轧态纯铜靶材,采用磁控溅射工艺制备纯铜薄膜,并对薄膜... 采用真空感应熔炼、均匀化退火、锻造、温轧和退火工艺制备纯铜靶材,研究了温轧态和不同温度(400,500,600,700℃)退火态纯铜靶材的微观结构;利用微观结构最优的退火态纯铜靶材和温轧态纯铜靶材,采用磁控溅射工艺制备纯铜薄膜,并对薄膜进行不同温度(300,400,500℃)的退火处理,研究了沉积态和退火态薄膜的微观结构和电学性能。结果表明:温轧态纯铜靶材的晶粒尺寸分布不均匀,退火后纯铜靶材发生回复与再结晶,随着退火温度的升高,回复与再结晶程度增加,晶粒尺寸分布逐渐均匀;当回火温度为600℃时,晶粒接近等轴晶,平均晶粒尺寸约为39.30μm,但当退火温度升高到700℃时,晶粒明显长大,平均晶粒尺寸增加到53.64μm;温轧态和退火态纯铜靶材表面均出现较高程度的(111)晶面择优取向,中心则出现较高程度的(220)晶面择优取向;600℃退火态纯铜靶材的微观结构最优。与采用温轧态纯铜靶材制备的退火态薄膜相比,采用退火态纯铜靶材制备的退火态薄膜的氧化程度、颗粒尺寸、表面粗糙度、电阻率均更小,(111)晶面择优取向程度更大。随着退火温度的升高,薄膜表面粗糙度先减小后增大,电阻率降低;当退火温度高于300℃时,薄膜出现颗粒团聚氧化现象。600℃退火态纯铜靶材制备的纯铜薄膜在300℃退火后具有最优异的微观结构和性能。 展开更多
关键词 磁控溅射 纯铜靶材 铜薄膜 温轧 退火 微观结构
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