With the rapid development of science and technology,the minimally invasive surgery(MIS)has become a reality.MIS is associated with less pain,a shorter hospital stay and fewer complications.The higher-quality minimall...With the rapid development of science and technology,the minimally invasive surgery(MIS)has become a reality.MIS is associated with less pain,a shorter hospital stay and fewer complications.The higher-quality minimally invasive instruments allow the surgeons to perform the surgical interventions efficiently without sacrificing patient safety.Therefore,the academic research,technology development,achievement transformation as well as clinical application of minimally invasive devices is extremely important。展开更多
The article aims to underline the impact of nicotine and pesticides on neuronal <i>α</i>7-nicotinic acetylcholine receptors expression in brainstem regions receiving cholinergic projections, given their f...The article aims to underline the impact of nicotine and pesticides on neuronal <i>α</i>7-nicotinic acetylcholine receptors expression in brainstem regions receiving cholinergic projections, given their fundamental role during the neuronal development. The in-depth histopathological/immunohistochemical examination of the autonomic nervous system performed at the “Lino Rossi” Research Center of the Milan University on a wide group of sudden unexpected fetal and infant deaths, highlighted the frequent hypodevelopment of brainstem structures checking the vital functions associated to altered expression of <i>α</i>7-nicotinic acetylcholine receptors and smoke absorption in pregnancy. A dysregulation of the catecholamine system was also observed in the cerebellar cortex of the same cases. However, in a not negligible percentage of sudden deaths with altered expression of <i>α</i>7-nicotinic receptors, the mothers never smoked but lived in rural areas. Specific analytical procedures showed the presence of agricultural pesticides in cerebral cortex samples of these victims. Therefore, it is possible to believe that the exposition to pesticides during pregnancy can produce the same harmful effects as nicotine on the nicotinic acetylcholine receptors. Moreover, alterations of <i>α</i>7-nicotinic acetylcholine receptors receptor expression were also detected in the lungs of many sudden perinatal death victims, allowing to consider even these findings as possible consequence of maternal exposure to toxic factors.展开更多
This issue of Cancer Biology & Medicine, a premium Chinese international scientific journal in this field, focuses on cooperation between Chinese and German cancer research, particularly between the Tianjin Medica...This issue of Cancer Biology & Medicine, a premium Chinese international scientific journal in this field, focuses on cooperation between Chinese and German cancer research, particularly between the Tianjin Medical University Cancer Institute & Hospital and the German Cancer Research Center(DKFZ) with its networking partners. This editorial provides a brief overview on DKFZ’s research strategy with a focus on how a national integrated cancer research and care ecosystem is evolving that benefits patients and society.展开更多
On December 15,2008,the International Research Center on Karst under the Auspices of UNESCO (hereinafter referred as IRCK)was formally established in Guilin,China.It is also the first category Ⅱ center concerning geo...On December 15,2008,the International Research Center on Karst under the Auspices of UNESCO (hereinafter referred as IRCK)was formally established in Guilin,China.It is also the first category Ⅱ center concerning geosciences.Since its foundation,it has organized 11 international symposia, attracted over 200 foreign scientists from more than 40 countries for academic exchange,and signed 16 international cooperation agreements with 14 countries.It has played an active role for international exchange,set firm foundation for cooperative projects.展开更多
The Belt and Road Initiative has brought rich and diverse possibilities to global cooperation,recommending that countries strengthen multilateral cooperation,help each other,and jointly face and resolve various risks.
Under the backdrop of“Carbon Peak and Carbon Neutrality”(dual carbon)goal in China,the methane-carbon dioxide reforming reaction has attracted considerable attention due to its environmental benefits of converting t...Under the backdrop of“Carbon Peak and Carbon Neutrality”(dual carbon)goal in China,the methane-carbon dioxide reforming reaction has attracted considerable attention due to its environmental benefits of converting two greenhouse gases(methane and carbon dioxide)into syngas and its promising industrial applications.Nickel(Ni)-based catalysts,with high catalytic activity,low cost,and abundant resources,are considered ideal candidates for industrial applications.In this article,three reaction kinetic models were briefly introduced,namely the Power-Law(PL)model,the Eley-Rideal(ER)model,and the Langmuir-Hinshelwood-Hougen-Watson(LHHW)model.Based on the LHHW model,the reaction kinetics and mechanisms of different catalytic systems were systematically discussed,including the properties of supports,the doping of noble metals and transition metals,the role of promoters,and the influence of the geometric and electronic structures of Ni on the reaction mechanism.Furthermore,the kinetics of carbon deposition and elimination on various catalysts were analyzed.Based on the reaction rate expressions for carbon elimination,the reasons for the high activity of transition metal iron(Fe)-doped catalysts and core-shell structured catalysts in carbon elimination were explained.Based on the detailed collation and comparative analysis of the reaction mechanisms and kinetic characteristics across diverse Ni-based catalytic systems,a theoretical guidance for the designing of high-performance catalysts was provided in this work.展开更多
AIM:To present an overview of the research on global glaucoma treatment in the last decade in terms of publication year,journals,countries/regions,organizations,references,and keywords,to investigate the current resea...AIM:To present an overview of the research on global glaucoma treatment in the last decade in terms of publication year,journals,countries/regions,organizations,references,and keywords,to investigate the current research international trends and hot topics in this area.METHODS:Bibliometric analysis was conducted on 9128 articles in the Web of Science Core Collection(WoSCC;Clarivate)database.Quantitative and qualitative analysis was employed using VOSviewer(v1.6.18),Pajek(v1.0.0.0),and CiteSpace(v6.1.R2)software.RESULTS:The 9128 papers relating to glaucoma treatment were published from April 2013 to April 2023,of which 7482 articles(82%)were original research articles and 1464(18%)were review articles.The United States(2867)and Johns Hopkins University(166)were the most productive country and institution,respectively,but the University College London had the highest h-index(54).The Journal of Glaucoma was the most productive and Ophthalmology had the highest h-index compared with other journals.The Keywords of interest included treatment surgery,cyclophotocoagulation,minimally invasive glaucoma surgery(MIGS),trabeculectomy,baerveldt,epidemiology,medication adherence,nanoparticle,optical coherence tomography(OCT),gene therapy,and artificial intelligence(AI).Glaucoma surgery appeared as a current research hotspot through the analysis of keywords.CONCLUSION:This study provides insights into the research trends and potential research hotspots in the treatment of glaucoma.This will help researchers to evaluate research policies and to promote international cooperation.展开更多
The existence of the"stomach-knee axis"and the potential independent association between"Helicobacter pylori(Hp)infection and knee osteoarthritis(KOA)"have been substantiated through multiple lines...The existence of the"stomach-knee axis"and the potential independent association between"Helicobacter pylori(Hp)infection and knee osteoarthritis(KOA)"have been substantiated through multiple lines of evidence,including epidemiological studies of the"stomach-knee axis",investigations into the pathological mechanisms linking"Hp infection and arthritis",as well as research on co-treatment drugs and the anti-inflammatory mechanisms relevant to"gastritis and arthritis".The investigation into"stomach and knee joint treatment"is grounded in the concept that the"stomach-knee axis"aligns with the"combined bi of body constituents and zang organs"theory.Clinical cases have demonstrated that therapeutic strategies of"stomach and knee joint treatment"can mitigate KOA damage by modulating the"stomach-knee axis"and eradicating Hp infection in the stomach.This study aims to contribute novel insights into the cross-system treatment of KOA.Further investigation into the"stomach-knee axis"may yield innovative strategies for the prevention and management of KOA,potentially through the eradication of Hp.展开更多
In recent years,the rapid advancement of artificial intelligence(AI)technology has enabled AI-assisted negative screening to significantly enhance physicians'efficiency through image feature analysis and multimoda...In recent years,the rapid advancement of artificial intelligence(AI)technology has enabled AI-assisted negative screening to significantly enhance physicians'efficiency through image feature analysis and multimodal data modeling,allowing them to focus more on diagnosing positive cases.Meanwhile,multispectral imaging(MSI)integrates spectral and spatial resolution to capture subtle tissue features invisible to the human eye,providing high-resolution data support for pathological analysis.Combining AI technology with MSI and employing quantitative methods to analyze multiband biomarkers(such as absorbance differences in keratin pearls)can effectively improve diagnostic specificity and reduce subjective errors in manual slide interpretation.To address the challenge of identifying negative tissue sections,we developed a discrimination algorithm powered by MSI.We demonstrated its efficacy using cutaneous squamous cell carcinoma(cSCC)as a representative case study.The algorithm achieved 100%accuracy in excluding negative cases and effectively mitigated the false-positive problem caused by cSCC heterogeneity.We constructed a multispectral image(MSI)dataset acquired at 520 nm,600 nm,and 630 nm wavelengths.Subsequently,we employed an optimized MobileViT model for tissue classification and performed comparative analyses against other models.The experimental results showed that our optimized MobileViT model achieved superior performance in identifying negative tissue sections,with a perfect accuracy rate of 100%.Thus,our results confirm the feasibility of integrating MSI with AI to exclude negative cases with perfect accuracy,offering a novel solution to alleviate the workload of pathologists.展开更多
Background:Laparoscopic anatomic hepatectomy of segment 7(LAH-S7)is a challenging surgery.In this study we aimed to investigate surgical and oncological outcomes of various approaches of LAH-S7 in patients with hepato...Background:Laparoscopic anatomic hepatectomy of segment 7(LAH-S7)is a challenging surgery.In this study we aimed to investigate surgical and oncological outcomes of various approaches of LAH-S7 in patients with hepatocellular carcinoma(HCC).A particular focus was placed on identifying the Glissonean pedicle of segment 7(G7)and the intersegmental plane.Given the scarcity of comprehensive reviews or comparative studies on clinical outcomes,we also sought to analyze the experiences and advantages associated with different approaches in relation to the anatomic variations of G7.Methods:The clinical data of 124 patients who underwent LAH-S7 for HCC across seven tertiary referral medical centers in China were retrospectively analyzed.Three surgical approaches were categorized based on the procedures used for G7 identification:the indocyanine green(ICG)fluorescence positive staining approach(IFPA),the Glissonean approach(GA),and the hepatic vein-guided approach(HVGA).Subsequently,the postoperative short-term results and oncological outcomes of the three different approaches were compared.Results:The distribution of surgical approaches among the patients was as follows:IFPA in 16(12.9%),GA in 62(50.0%),and HVGA in 46(37.1%)patients.Complications were observed in 27(21.8%)patients.The 1-,3-,and 5-year overall survival(OS)rates were 99.1%,89.2%,and 84.7%,respectively.The 1-,3-,and 5-year recurrence-free survival(RFS)rates were 99.0%,84.7%,and 69.3%,respectively.The OS and RFS rates were comparable across the three approaches.Conclusions:Following a standardized surgical procedure,LAH-S7 is demonstrated to be safe and yields favorable oncological outcomes.Surgeons performing LAH-S7 should select the appropriate surgical approach based on the anatomical characteristics and variations of G7.展开更多
In the last century the impacts of human activity on natural processes that sustain the Earth’s biosphere,atmosphere,hydrosphere and lithosphere and that provide the bed-rock of human life support systems,have grown ...In the last century the impacts of human activity on natural processes that sustain the Earth’s biosphere,atmosphere,hydrosphere and lithosphere and that provide the bed-rock of human life support systems,have grown to the extent that they pose a credible existential threat to humanity.Today,the biggest challenge for science,technology and innovation(STI)is to contribute to the pursuit of global sustainability as exemplified in the Sustainable Development Goals(SDGs)that were adopted by the United Nations(UN)in 2015.展开更多
The rapid development of analytics and concepts in big data enables us to diversify our efforts and enhance opportunities to implement the Sustainable Development Goals(SDGs).Big data improves the extent to which scie...The rapid development of analytics and concepts in big data enables us to diversify our efforts and enhance opportunities to implement the Sustainable Development Goals(SDGs).Big data improves the extent to which scientific evidence and innova-tive technological solutions can be adopted to meet these goals.However,the tools and methods of big data are still somewhat of a novelty in this respect.展开更多
In July 2013, the National Development and Reform Com- mission formally approved the ＂National Research Center for Translational Medicine-Shanghai＂ （hereinafter ＂the Center＂）, a piece of the national key scienti...In July 2013, the National Development and Reform Com- mission formally approved the ＂National Research Center for Translational Medicine-Shanghai＂ （hereinafter ＂the Center＂）, a piece of the national key scientific infrastruc- ture. As a national-level institution, the Center will be co-administered by the Ministry of Education and the Shanghai Municipal Government.展开更多
Although there are certain differences in the center of gravity between rural revitalization and human-centered urbanization,their connotations and goals require that both must be promoted in concert.Therefore,based o...Although there are certain differences in the center of gravity between rural revitalization and human-centered urbanization,their connotations and goals require that both must be promoted in concert.Therefore,based on a deep understanding of the connotation of rural revitalization and human-centered urbanization,it is necessary to clarify the goals of the two through the two-way flow of elements between urban and rural areas,the urban-rural linkage of industries,to achieve coordinated promotion of rural revitalization and human-centered urbanization in China.展开更多
As the basic conditions for laser inertial confinement fusion(ICF) research, the targets are required to be well specified and elaborately fabricated. Because of the characteristics of the targets, the research and fa...As the basic conditions for laser inertial confinement fusion(ICF) research, the targets are required to be well specified and elaborately fabricated. Because of the characteristics of the targets, the research and fabrication process is a systematically tough task, which needs fundamental and deep insights into film deposition, mechanical machining,precise measurement and assembly, etc. As a result, knowledge of material science, physics, mechanical as well as electronics is a necessity for target researchers. In this paper, we give introductions to the state of art on target fabrication for ICF research at Research Center of Laser Fusion(RCLF) in China.展开更多
Objective： Among the injury types, sports ones constitute a considerable proportion of patients who refer to the medical centers. This research was conducted to examine the frequency of sports- related injuries refer...Objective： Among the injury types, sports ones constitute a considerable proportion of patients who refer to the medical centers. This research was conducted to examine the frequency of sports- related injuries referring to Kashan University of Medical Sciences Trauma Research Center from 2005 to 2011. Methods： This was a retrospective research in which existing data from the data bank of Kashan University of Medical Sciences Trauma Research Center were employed. The data were extracted from the main source by SPSS version 16.0. Variables such as age, education, occupation and gender were analyzed. Results： The highest proportion of injuries was observed in students （59.4%） followed by workers （11.8%）. Upper and lower extremities were most commonly injured. The most frequent injury was strain （35.4%）, followed by sprain （27.7%）. Conclusion： The results of this research showed that the majority of the sports trauma occurrs in students; therefore, they need more attention in regard to sports injuries. Preventive measures such as informing the coaches and teachers as well as increasing the students＇ awareness about the injury risk can decrease the incidences of sports injuries.展开更多
Distributed testing system has strong applicability in the field of dynamic testing,which can centrally manage the testing equipment in different locations through the local area network,and meet the new requirements ...Distributed testing system has strong applicability in the field of dynamic testing,which can centrally manage the testing equipment in different locations through the local area network,and meet the new requirements of the test.Based on the theory of seismic location,the location of underground explosion center was studied.The applicability of seismic location theory to the location of underground explosion center was verified by simulating the underground explosion with LS-DYNA simulation platform.Combined with distributed testing system theory and weighting method,the optimal distribution method of test points was summarized through data analysis.展开更多
This paper summarizes the development experience of the subcenters in leading provinces, including their establishment mode, strategic positioning, development mode and economic development. It also analyzes the econo...This paper summarizes the development experience of the subcenters in leading provinces, including their establishment mode, strategic positioning, development mode and economic development. It also analyzes the economic development characteristics, regional patterns, and location distributions of Mianyang, Deyang, Leshan, Yibin, Luzhou, Nanchong and Dazhou, the seven alternative subcenters in Sichuan province. It focuses on the analysis of their basic situations regarding scientific and technological(S&T) innovation development including investment in S&T innovation, talent team construction, S&T achievements, industrial structure and S&T platforms compared with the innovative subcenters in leading provinces. Results show that the scale of S&T innovation activities in the seven alternative subcenters in Sichuan province needs to be improved. Finally, based on the ChengduChongqing economic circle strategy, this paper puts forward the thoughts and suggestions on how to cultivate the innovative subcenters in Sichuan province.展开更多
文摘With the rapid development of science and technology,the minimally invasive surgery(MIS)has become a reality.MIS is associated with less pain,a shorter hospital stay and fewer complications.The higher-quality minimally invasive instruments allow the surgeons to perform the surgical interventions efficiently without sacrificing patient safety.Therefore,the academic research,technology development,achievement transformation as well as clinical application of minimally invasive devices is extremely important。
文摘The article aims to underline the impact of nicotine and pesticides on neuronal <i>α</i>7-nicotinic acetylcholine receptors expression in brainstem regions receiving cholinergic projections, given their fundamental role during the neuronal development. The in-depth histopathological/immunohistochemical examination of the autonomic nervous system performed at the “Lino Rossi” Research Center of the Milan University on a wide group of sudden unexpected fetal and infant deaths, highlighted the frequent hypodevelopment of brainstem structures checking the vital functions associated to altered expression of <i>α</i>7-nicotinic acetylcholine receptors and smoke absorption in pregnancy. A dysregulation of the catecholamine system was also observed in the cerebellar cortex of the same cases. However, in a not negligible percentage of sudden deaths with altered expression of <i>α</i>7-nicotinic receptors, the mothers never smoked but lived in rural areas. Specific analytical procedures showed the presence of agricultural pesticides in cerebral cortex samples of these victims. Therefore, it is possible to believe that the exposition to pesticides during pregnancy can produce the same harmful effects as nicotine on the nicotinic acetylcholine receptors. Moreover, alterations of <i>α</i>7-nicotinic acetylcholine receptors receptor expression were also detected in the lungs of many sudden perinatal death victims, allowing to consider even these findings as possible consequence of maternal exposure to toxic factors.
文摘This issue of Cancer Biology & Medicine, a premium Chinese international scientific journal in this field, focuses on cooperation between Chinese and German cancer research, particularly between the Tianjin Medical University Cancer Institute & Hospital and the German Cancer Research Center(DKFZ) with its networking partners. This editorial provides a brief overview on DKFZ’s research strategy with a focus on how a national integrated cancer research and care ecosystem is evolving that benefits patients and society.
文摘On December 15,2008,the International Research Center on Karst under the Auspices of UNESCO (hereinafter referred as IRCK)was formally established in Guilin,China.It is also the first category Ⅱ center concerning geosciences.Since its foundation,it has organized 11 international symposia, attracted over 200 foreign scientists from more than 40 countries for academic exchange,and signed 16 international cooperation agreements with 14 countries.It has played an active role for international exchange,set firm foundation for cooperative projects.
文摘The Belt and Road Initiative has brought rich and diverse possibilities to global cooperation,recommending that countries strengthen multilateral cooperation,help each other,and jointly face and resolve various risks.
基金Supported by Innovation Capability Support Program of Shaanxi(2024RS-CXTD-53,2024ZC-KJXX-096)the Key R&D Program of Shaanxi Province(2022QCY-LL-69)Xi’an Science and Technology Project(24GXFW0089)。
文摘Under the backdrop of“Carbon Peak and Carbon Neutrality”(dual carbon)goal in China,the methane-carbon dioxide reforming reaction has attracted considerable attention due to its environmental benefits of converting two greenhouse gases(methane and carbon dioxide)into syngas and its promising industrial applications.Nickel(Ni)-based catalysts,with high catalytic activity,low cost,and abundant resources,are considered ideal candidates for industrial applications.In this article,three reaction kinetic models were briefly introduced,namely the Power-Law(PL)model,the Eley-Rideal(ER)model,and the Langmuir-Hinshelwood-Hougen-Watson(LHHW)model.Based on the LHHW model,the reaction kinetics and mechanisms of different catalytic systems were systematically discussed,including the properties of supports,the doping of noble metals and transition metals,the role of promoters,and the influence of the geometric and electronic structures of Ni on the reaction mechanism.Furthermore,the kinetics of carbon deposition and elimination on various catalysts were analyzed.Based on the reaction rate expressions for carbon elimination,the reasons for the high activity of transition metal iron(Fe)-doped catalysts and core-shell structured catalysts in carbon elimination were explained.Based on the detailed collation and comparative analysis of the reaction mechanisms and kinetic characteristics across diverse Ni-based catalytic systems,a theoretical guidance for the designing of high-performance catalysts was provided in this work.
基金Suppotred by Tianjin Key Medical Discipline Construction Project(No.TJYXZDXK-3-004A-2).
文摘AIM:To present an overview of the research on global glaucoma treatment in the last decade in terms of publication year,journals,countries/regions,organizations,references,and keywords,to investigate the current research international trends and hot topics in this area.METHODS:Bibliometric analysis was conducted on 9128 articles in the Web of Science Core Collection(WoSCC;Clarivate)database.Quantitative and qualitative analysis was employed using VOSviewer(v1.6.18),Pajek(v1.0.0.0),and CiteSpace(v6.1.R2)software.RESULTS:The 9128 papers relating to glaucoma treatment were published from April 2013 to April 2023,of which 7482 articles(82%)were original research articles and 1464(18%)were review articles.The United States(2867)and Johns Hopkins University(166)were the most productive country and institution,respectively,but the University College London had the highest h-index(54).The Journal of Glaucoma was the most productive and Ophthalmology had the highest h-index compared with other journals.The Keywords of interest included treatment surgery,cyclophotocoagulation,minimally invasive glaucoma surgery(MIGS),trabeculectomy,baerveldt,epidemiology,medication adherence,nanoparticle,optical coherence tomography(OCT),gene therapy,and artificial intelligence(AI).Glaucoma surgery appeared as a current research hotspot through the analysis of keywords.CONCLUSION:This study provides insights into the research trends and potential research hotspots in the treatment of glaucoma.This will help researchers to evaluate research policies and to promote international cooperation.
基金Supported by Discipline Construction Project of Shanxi University of Chinese Medicine—Internal Medicine of Traditional Chinese Medicine(2025XK02).
文摘The existence of the"stomach-knee axis"and the potential independent association between"Helicobacter pylori(Hp)infection and knee osteoarthritis(KOA)"have been substantiated through multiple lines of evidence,including epidemiological studies of the"stomach-knee axis",investigations into the pathological mechanisms linking"Hp infection and arthritis",as well as research on co-treatment drugs and the anti-inflammatory mechanisms relevant to"gastritis and arthritis".The investigation into"stomach and knee joint treatment"is grounded in the concept that the"stomach-knee axis"aligns with the"combined bi of body constituents and zang organs"theory.Clinical cases have demonstrated that therapeutic strategies of"stomach and knee joint treatment"can mitigate KOA damage by modulating the"stomach-knee axis"and eradicating Hp infection in the stomach.This study aims to contribute novel insights into the cross-system treatment of KOA.Further investigation into the"stomach-knee axis"may yield innovative strategies for the prevention and management of KOA,potentially through the eradication of Hp.
基金funded by the Natural Science Foundation of Shanghai Municipality(No.21ZR1440500)the Shanghai Science and Technology Commission(Grant No.21S31902700).
文摘In recent years,the rapid advancement of artificial intelligence(AI)technology has enabled AI-assisted negative screening to significantly enhance physicians'efficiency through image feature analysis and multimodal data modeling,allowing them to focus more on diagnosing positive cases.Meanwhile,multispectral imaging(MSI)integrates spectral and spatial resolution to capture subtle tissue features invisible to the human eye,providing high-resolution data support for pathological analysis.Combining AI technology with MSI and employing quantitative methods to analyze multiband biomarkers(such as absorbance differences in keratin pearls)can effectively improve diagnostic specificity and reduce subjective errors in manual slide interpretation.To address the challenge of identifying negative tissue sections,we developed a discrimination algorithm powered by MSI.We demonstrated its efficacy using cutaneous squamous cell carcinoma(cSCC)as a representative case study.The algorithm achieved 100%accuracy in excluding negative cases and effectively mitigated the false-positive problem caused by cSCC heterogeneity.We constructed a multispectral image(MSI)dataset acquired at 520 nm,600 nm,and 630 nm wavelengths.Subsequently,we employed an optimized MobileViT model for tissue classification and performed comparative analyses against other models.The experimental results showed that our optimized MobileViT model achieved superior performance in identifying negative tissue sections,with a perfect accuracy rate of 100%.Thus,our results confirm the feasibility of integrating MSI with AI to exclude negative cases with perfect accuracy,offering a novel solution to alleviate the workload of pathologists.
基金supported by grants from the Scientific Research Fund of Education Department of Yunnan Province(2023J767)the National Natural Science Foundation of China(82272963 and 82472718)+6 种基金Health Research Project of Hunan Provincial Health Commission(W20242019)Hunan Provincial Health High-Level Talent Scientific Research Project(R2023096)Hunan Provincial Department of Science and Technology Health Industry Joint Fund(2024JJ9479)Guangdong Province Basic and Applied Basic Research Foundation Project-Guangdong Province Natural Science Foundation(2024A1515220154)"Leading Goose"Project of the Science and Technology Department of Zhejiang Province(2024C03049)Major Project of Health Science and Technology Program of Zhejiang Province(WKJ-ZJ-2407)the National Key Research and Development Program(2024YFB331170204).
文摘Background:Laparoscopic anatomic hepatectomy of segment 7(LAH-S7)is a challenging surgery.In this study we aimed to investigate surgical and oncological outcomes of various approaches of LAH-S7 in patients with hepatocellular carcinoma(HCC).A particular focus was placed on identifying the Glissonean pedicle of segment 7(G7)and the intersegmental plane.Given the scarcity of comprehensive reviews or comparative studies on clinical outcomes,we also sought to analyze the experiences and advantages associated with different approaches in relation to the anatomic variations of G7.Methods:The clinical data of 124 patients who underwent LAH-S7 for HCC across seven tertiary referral medical centers in China were retrospectively analyzed.Three surgical approaches were categorized based on the procedures used for G7 identification:the indocyanine green(ICG)fluorescence positive staining approach(IFPA),the Glissonean approach(GA),and the hepatic vein-guided approach(HVGA).Subsequently,the postoperative short-term results and oncological outcomes of the three different approaches were compared.Results:The distribution of surgical approaches among the patients was as follows:IFPA in 16(12.9%),GA in 62(50.0%),and HVGA in 46(37.1%)patients.Complications were observed in 27(21.8%)patients.The 1-,3-,and 5-year overall survival(OS)rates were 99.1%,89.2%,and 84.7%,respectively.The 1-,3-,and 5-year recurrence-free survival(RFS)rates were 99.0%,84.7%,and 69.3%,respectively.The OS and RFS rates were comparable across the three approaches.Conclusions:Following a standardized surgical procedure,LAH-S7 is demonstrated to be safe and yields favorable oncological outcomes.Surgeons performing LAH-S7 should select the appropriate surgical approach based on the anatomical characteristics and variations of G7.
文摘In the last century the impacts of human activity on natural processes that sustain the Earth’s biosphere,atmosphere,hydrosphere and lithosphere and that provide the bed-rock of human life support systems,have grown to the extent that they pose a credible existential threat to humanity.Today,the biggest challenge for science,technology and innovation(STI)is to contribute to the pursuit of global sustainability as exemplified in the Sustainable Development Goals(SDGs)that were adopted by the United Nations(UN)in 2015.
文摘The rapid development of analytics and concepts in big data enables us to diversify our efforts and enhance opportunities to implement the Sustainable Development Goals(SDGs).Big data improves the extent to which scientific evidence and innova-tive technological solutions can be adopted to meet these goals.However,the tools and methods of big data are still somewhat of a novelty in this respect.
文摘In July 2013, the National Development and Reform Com- mission formally approved the ＂National Research Center for Translational Medicine-Shanghai＂ （hereinafter ＂the Center＂）, a piece of the national key scientific infrastruc- ture. As a national-level institution, the Center will be co-administered by the Ministry of Education and the Shanghai Municipal Government.
基金Supported by Key Project of Humanities and Social Sciences of Hubei Provincial Education Department——"Research on the Agricultural Supply-side Structural Reform Based on the Integration of Three Rural Industries"(18D031).
文摘Although there are certain differences in the center of gravity between rural revitalization and human-centered urbanization,their connotations and goals require that both must be promoted in concert.Therefore,based on a deep understanding of the connotation of rural revitalization and human-centered urbanization,it is necessary to clarify the goals of the two through the two-way flow of elements between urban and rural areas,the urban-rural linkage of industries,to achieve coordinated promotion of rural revitalization and human-centered urbanization in China.
基金supported by Laboratory of Precision Manufacturing Technology,CAEP(Grant No.ZD16002)
文摘As the basic conditions for laser inertial confinement fusion(ICF) research, the targets are required to be well specified and elaborately fabricated. Because of the characteristics of the targets, the research and fabrication process is a systematically tough task, which needs fundamental and deep insights into film deposition, mechanical machining,precise measurement and assembly, etc. As a result, knowledge of material science, physics, mechanical as well as electronics is a necessity for target researchers. In this paper, we give introductions to the state of art on target fabrication for ICF research at Research Center of Laser Fusion(RCLF) in China.
文摘Objective： Among the injury types, sports ones constitute a considerable proportion of patients who refer to the medical centers. This research was conducted to examine the frequency of sports- related injuries referring to Kashan University of Medical Sciences Trauma Research Center from 2005 to 2011. Methods： This was a retrospective research in which existing data from the data bank of Kashan University of Medical Sciences Trauma Research Center were employed. The data were extracted from the main source by SPSS version 16.0. Variables such as age, education, occupation and gender were analyzed. Results： The highest proportion of injuries was observed in students （59.4%） followed by workers （11.8%）. Upper and lower extremities were most commonly injured. The most frequent injury was strain （35.4%）, followed by sprain （27.7%）. Conclusion： The results of this research showed that the majority of the sports trauma occurrs in students; therefore, they need more attention in regard to sports injuries. Preventive measures such as informing the coaches and teachers as well as increasing the students＇ awareness about the injury risk can decrease the incidences of sports injuries.
基金Open Research Fund for Key Laboratory of Damage Technology(No.DXMBJJ2017-12)。
文摘Distributed testing system has strong applicability in the field of dynamic testing,which can centrally manage the testing equipment in different locations through the local area network,and meet the new requirements of the test.Based on the theory of seismic location,the location of underground explosion center was studied.The applicability of seismic location theory to the location of underground explosion center was verified by simulating the underground explosion with LS-DYNA simulation platform.Combined with distributed testing system theory and weighting method,the optimal distribution method of test points was summarized through data analysis.
文摘This paper summarizes the development experience of the subcenters in leading provinces, including their establishment mode, strategic positioning, development mode and economic development. It also analyzes the economic development characteristics, regional patterns, and location distributions of Mianyang, Deyang, Leshan, Yibin, Luzhou, Nanchong and Dazhou, the seven alternative subcenters in Sichuan province. It focuses on the analysis of their basic situations regarding scientific and technological(S&T) innovation development including investment in S&T innovation, talent team construction, S&T achievements, industrial structure and S&T platforms compared with the innovative subcenters in leading provinces. Results show that the scale of S&T innovation activities in the seven alternative subcenters in Sichuan province needs to be improved. Finally, based on the ChengduChongqing economic circle strategy, this paper puts forward the thoughts and suggestions on how to cultivate the innovative subcenters in Sichuan province.
