Centering on the critical bottlenecks in the development of shale oil in the Jiyang Depression of Shengli Oilfield,key scientific and engineering issues are proposed in aspects such as the storage space and occurrence...Centering on the critical bottlenecks in the development of shale oil in the Jiyang Depression of Shengli Oilfield,key scientific and engineering issues are proposed in aspects such as the storage space and occurrence state of shale oil,the formation mechanisms of multi-scale flow spaces,the mobilization mechanisms of crude oil in pores and fractures,and the enhanced oil recovery(EOR)mechanisms during the late stage of elastic development.The research progress and mechanistic insights in recent years are reviewed with respect to experimental techniques,characteristics of pore-fracture structure and fluid occurrence,fracture evolution mechanisms,shale oil flow mechanisms and EOR techniques.Through improving the experimental methods,optimizing the testing conditions,and developing new technologies,we deeply understand the occurrence state,storage space and flow pattern of shale oil,and reveal the distribution pattern of“oil-bearing in all pore sizes and oil-rich in large pores”and the differences in fluid phase states under the confinement effect of nano-scale pores in the shales of the Jiyang Depression;depict the characteristics of“restricted vertical expansion and complex fracture networks”of induced fractures and the dynamic evolution of fracture networks during the fracturing-soaking-production process;establish a“easy flow-slow flow-stagnant flow”three-zone model and the elastic drive+imbibition drive synergistic energy replenishment mechanism;and carry out high-pressure injection to further enhance the mass transfer and diffusion capacity of CO_(2)within the shale pore-fracture system,and compete for the desorption of alkanes to improve the mobilization degree of shale oil.The research achievements provide crucial support for the formation of the theory of continental shale oil development and the construction of the technical system.The future research efforts will focus on mine-scale multi-field coupling physical simulation equipment,microscopic to macroscopic multi-scale experimental methods,pore/fracture fine characterization and post-fracturing core fracture description technologies,multi-media fluid-structure coupling numerical simulation algorithms,and low-cost EOR and low-quality shale oil in-situ upgrading technologies,in order to promote the large-scale and profitable development of shale oil in the Jiyang Depression.展开更多
In 2025,I had the honor of delivering keynote speeches at the conferences of the International Society for Diet and Activity Methods in Toronto,Canada,and the International Society of Behavioural Nutrition and Physica...In 2025,I had the honor of delivering keynote speeches at the conferences of the International Society for Diet and Activity Methods in Toronto,Canada,and the International Society of Behavioural Nutrition and Physical Activity in Auckland,Aotearoa,New Zealand.These opportunities prompted deep reflection on scientific research in general,and on physical activity and health research specifically.展开更多
A soft X-ray energy materials research beamline(BL20U2),a branch of energy materials beamline(E-line),has been constructed in the Shanghai Synchrotron Radiation Facility(SSRF)Phase-Ⅱ project.It is now operational for...A soft X-ray energy materials research beamline(BL20U2),a branch of energy materials beamline(E-line),has been constructed in the Shanghai Synchrotron Radiation Facility(SSRF)Phase-Ⅱ project.It is now operational for soft X-ray resonant emission spectroscopy(RXES)and soft X-ray resonant elastic scattering(REXS)investigations.Optical optimization was implemented for high performance,e.g.,photon flux,energy-resolving power,and focus spot size.RXES experiments show that the energy range extends from 150 to 1500 eV.The elastic peak measured near titanium absorption edge(@445 eV)indicates an energy resolution of the RXES spectrometer of 65 meV.The measured photon flux is 3×10^(12)photons/s at 244 eV at the RXES sample position for an SSRF electron energy of 3.5 GeV and a projected ring current as 300 mA.The spot size at the RXES sample position is 23μm in the horizontal direction and 7.9μm in the vertical direction,respectively.Moreover,the angular resolution of elastic REXS scatterometer reaches 0.005°through measurement of X-ray reflection from the single-crystal silicon wafers.A sample of the REXS scatterometer is vibrationally decoupled from its chamber and cooled using copper braids connected from an open cycle liquid helium cryo reservoir,whereas the minimum sample temperature is below 15 K.展开更多
Educational cooperation,as the cornerstone and vanguard of people-to-people exchanges and practical cooperation between China and Africa,holds irreplaceable strategic significance for enhancing the quality of Africa&#...Educational cooperation,as the cornerstone and vanguard of people-to-people exchanges and practical cooperation between China and Africa,holds irreplaceable strategic significance for enhancing the quality of Africa's human capital and accelerating its structural transformation and modernization process.This paper employs“demand–supply–adaptation”as its core analytical framework and aims to systematically explore how the educational cooperation between China and Africa can serve Africa's goal of modernization more precisely and effectively.First,through reviewing and analyzing the domestic and international research literature,this paper clarifies the focus,paradigms,and shortcomings of existing research,identifying the knowledge contribution of this study.Second,utilizing detailed macro-level data,case studies,and comparative research methods,it comprehensively presents the multidimensional status,structural characteristics,and development trends of China–Africa educational cooperation in areas such as student exchanges,cooperative education,vocational and technical training,language and cultural exchange,and emerging digital education.This paper also deeply analyzes the pressing and specific demands placed on the education system by Africa's modernization development across key dimensions like economic diversification,industrialization,agricultural modernization,social governance upgrading,and digital transformation.Third,based on the cooperative principle of“Africa's needs and China's strengths,”this paper innovatively proposes systematic countermeasures and suggestions for constructing new,multi-level,high-quality,sustainable,and future-oriented pathways for China–Africa educational cooperation:(a)promoting the strategic focus of cooperation to extend from“hard infrastructure”support to empowering“soft infrastructure”;(b)deepening the integration of industry and education and school–enterprise collaboration to precisely align with Africa's industrial development needs;vigorously developing digital education and jointly building a smart education ecosystem to help Africa bridge the digital divide;(c)improving an evidence-based,third-party evaluation system for cooperative effectiveness and a full-process quality assurance system;and(d)promoting the collaborative participation of multiple actors including governments,schools,enterprises,think tanks,and social organizations to build a new cooperative pattern of coconstruction,co-governance,and shared benefits.展开更多
Both large-scale prospective randomized controlled trials(RCTs)and smaller investigator-initiated trials are essential for evaluating the efficacy and safety of medical interventions.Robust protocols and statistical d...Both large-scale prospective randomized controlled trials(RCTs)and smaller investigator-initiated trials are essential for evaluating the efficacy and safety of medical interventions.Robust protocols and statistical designs ensure the reliability of trial outcomes and improve the credibility of research findings.By reviewing the statistical approaches used in the TORCHLIGHT,NCC2167,and NeoTENNIS trials,this article illustrates the principles underlying large-sample confirmatory RCTs,small-sample exploratory adaptive designs,and single-arm two-stage designs.This discussion is aimed at helping researchers apply these design methods more effectively,to increase the likelihood of success in clinical studies.展开更多
By 2025,research on Traditional Chinese Medicine(TCM)meridians has generated 12-15 macro-level theories and over 20 specific hypotheses,manifesting a highly fragmented research landscape.Objective:This paper proposes ...By 2025,research on Traditional Chinese Medicine(TCM)meridians has generated 12-15 macro-level theories and over 20 specific hypotheses,manifesting a highly fragmented research landscape.Objective:This paper proposes the“Holistic Hierarchical Predictive-Integration Hypothesis”(HHPIT)to construct a unified theoretical framework that integrates the rational components of existing meridian hypotheses.Methods:The HHPIT hypothesis systematically reviews current meridian theories,employs interdisciplinary methodologies,integrates artificial intelligence technology,and establishes a three-tier architecture encompassing structural,functional,and systemic layers.Results:HHPIT successfully integrates diverse meridian theories,proposes a computable algorithmic pipeline,and provides specific application protocols for chronic disease treatment,anti-aging,and enhancement of Zang-fu organ functions.Conclusion:HHPIT offers a novel,computable,and verifiable research paradigm for meridian studies,promoting the modernization and internationalization of TCM theory.展开更多
While conventional FISH and IHC methods struggle to decode complex tissue heterogeneity and comprehensive molecular diagnosis due to low-throughput spatial information,spatial omics technologies enable high-throughput...While conventional FISH and IHC methods struggle to decode complex tissue heterogeneity and comprehensive molecular diagnosis due to low-throughput spatial information,spatial omics technologies enable high-throughput molecular mapping across tissue microenvironments.These technologies are emerging as transformative tools in molecular diagnostics and medical research.By integrating histopathological morphology with spatial multi-omics profiling(genome,transcriptome,epigenome,and proteome),spatial omics technologies open an avenue for understanding disease progression,therapeutic resistance mechanisms,and precise diagnosis.It particularly enhances tumor microenvironment analysis by mapping immune cell distributions and functional states,which may greatly facilitate tumor molecular subtyping,prognostic assessment,and prediction of the radiotherapy and chemotherapy efficacy.Despite the substantial advancements in spatial omics,the translation of spatial omics into clinical applications remains challenging due to robustness,efficacy,clinical validation,and cost constraints.In this review,we summarize the current progress and prospects of spatial omics technologies,particularly in medical research and diagnostic applications.展开更多
IR64 is an elite Xian/indica variety developed by International Rice Research Institute(IRRl)in 1985,which has been the most widely grown variety and core breeding parent in South/Southeast Asia(Mackill and Khush,2018...IR64 is an elite Xian/indica variety developed by International Rice Research Institute(IRRl)in 1985,which has been the most widely grown variety and core breeding parent in South/Southeast Asia(Mackill and Khush,2018).IR64 has been utilized to develop stress-tolerant(such as drought-adapted and submergenceresistant)near-isogenic lines,underscoring its great potential in agricultural genomics(Tanaka et al.,2020).展开更多
The convergence of artificial intelligence(AI)and big data is reshaping contemporary oncology by enabling the integration of multimodal information across imaging,pathology,genomics,and clinical records.From a physici...The convergence of artificial intelligence(AI)and big data is reshaping contemporary oncology by enabling the integration of multimodal information across imaging,pathology,genomics,and clinical records.From a physician-centered perspective,these technologies can potentially be used to improve diagnostic precision,support individualized treatment planning,enhance longitudinal patient management,and accelerate both clinical and translational research.In this review,we synthesize the core AI methodologies most relevant to oncology-machine learning,deep learning,and large language models-and examine how they interact with established and emerging oncology data platforms.We further highlight practical use cases in clinical workflows and research pipelines,emphasizing opportunities for advancing precision cancer care while also addressing challenges associated with data heterogeneity,model generalizability,privacy protection,and real-world implementation.By underscoring the synergistic value of AI and big data,this review aims to inform the development of clinically meaningful,context-adapted strategies that promote translational innovation in both global and locally resourced healthcare environments.展开更多
High-entropy alloys,a novel class of materials characterized by the statistical distribution of multiple principal elements on simple crystalline lattices,have emerged as a research hotspot in materials science and co...High-entropy alloys,a novel class of materials characterized by the statistical distribution of multiple principal elements on simple crystalline lattices,have emerged as a research hotspot in materials science and condensed matter physics due to their exceptional mechanical properties and unique high-entropy characteristic.Since the discovery of the first high-entropy superconductor in 2014,exploring their superconducting performance and advantages has progressively become a frontier in scientific research.The Ta-Nb-Hf-Zr-Ti system,in particular,exhibits remarkable mechanical robustness,outstanding radiation tolerance,and superconducting performance comparable to the binary NbTi alloy,positioning it as a promising candidate for advanced applications,such as high-field superconducting magnets,superconducting electric motors,and next-generation nuclear fusion reactors.This review systematically summarized global research progress on Ta-Nb-Hf-Zr-Ti-based superconductors,aiming to provide a comprehensive reference for advancing this burgeoning field.展开更多
Under the backdrop of“Carbon Peak and Carbon Neutrality”(dual carbon)goal in China,the methane-carbon dioxide reforming reaction has attracted considerable attention due to its environmental benefits of converting t...Under the backdrop of“Carbon Peak and Carbon Neutrality”(dual carbon)goal in China,the methane-carbon dioxide reforming reaction has attracted considerable attention due to its environmental benefits of converting two greenhouse gases(methane and carbon dioxide)into syngas and its promising industrial applications.Nickel(Ni)-based catalysts,with high catalytic activity,low cost,and abundant resources,are considered ideal candidates for industrial applications.In this article,three reaction kinetic models were briefly introduced,namely the Power-Law(PL)model,the Eley-Rideal(ER)model,and the Langmuir-Hinshelwood-Hougen-Watson(LHHW)model.Based on the LHHW model,the reaction kinetics and mechanisms of different catalytic systems were systematically discussed,including the properties of supports,the doping of noble metals and transition metals,the role of promoters,and the influence of the geometric and electronic structures of Ni on the reaction mechanism.Furthermore,the kinetics of carbon deposition and elimination on various catalysts were analyzed.Based on the reaction rate expressions for carbon elimination,the reasons for the high activity of transition metal iron(Fe)-doped catalysts and core-shell structured catalysts in carbon elimination were explained.Based on the detailed collation and comparative analysis of the reaction mechanisms and kinetic characteristics across diverse Ni-based catalytic systems,a theoretical guidance for the designing of high-performance catalysts was provided in this work.展开更多
[Objectives]To investigate the efficacy and potential mechanism of the topical preparation Jineijin-Shanzha Patch(composed of Galli Gigerii Endothelium Corneum and Crataegi Fructus)in improving functional dyspepsia(FD...[Objectives]To investigate the efficacy and potential mechanism of the topical preparation Jineijin-Shanzha Patch(composed of Galli Gigerii Endothelium Corneum and Crataegi Fructus)in improving functional dyspepsia(FD)based on network pharmacology.[Methods]Firstly,we reviewed the existing research progress on each constituent drug of the Jineijin Shanzha Patch for FD improvement.Following this,identified overlapping genes were utilized to construct both a"Drug-Active Component-FD Target"network and a Protein-Protein Interaction(PPI)network specific to the patch.In addition,Gene Ontology(GO)analysis was carried out.[Results]We identified that the 13 herbs in the Jineijin Shanzha Patch are mainly used for food stagnation,qi stagnation,and spleen deficiency.Screening revealed 43 active patch components,1414 FD-related targets,and 284 shared targets between them.The PPI network analysis further identified the top 10 core targets from these shared targets.From the"Drug-Active Component-FD Target"network,we identified the core elements.These included the herbal components Vignae Semen(from Liushenqu),Crataegi Fructus,and Pseudostellariae Radix;the active components quercetin,genistein,and apigenin;and the key targets CASP3,BCL2,and CASP9.GO analysis of the 284 overlapping targets indicated that the Jineijin Shanzha Patch may exert its therapeutic effects via regulation of biological processes such as the response to lipopolysaccharide,response to bacterium-derived molecules,and regulation of the apoptotic signaling pathway.[Conclusions]The main active components of the Jineijin Shanzha Patch(quercetin,genistein,and apigenin)may improve FD by modulating signaling pathways such as the response to lipopolysaccharide,response to bacterium-derived molecules,and regulation of the apoptotic signaling pathway,thereby acting on key targets including CASP3,BCL2,and CASP9.展开更多
This paper develops an innovative computational model for assessing the Carbon Emission Factor(CEF)of provincial power systems that incorporates inter-provincial electricity transfers and hybrid generation portfolios ...This paper develops an innovative computational model for assessing the Carbon Emission Factor(CEF)of provincial power systems that incorporates inter-provincial electricity transfers and hybrid generation portfolios combining conventional and renewable sources.A key contribution lies in evaluating how deep regulation of thermal power plants influence the carbon intensity of coal-fired generation and coal-fired generation together with high penetration renewables.Furthermore,the study quantitatively analyzes the role of renewable energy consumption and the prospective application of Carbon Capture and Storage(CCS)in reducing system-wide CEF.Based on this framework,the paper proposes phased carbon emission targets for Guangdong’s power system for key milestone years(2030,2045,2060),along with targeted implementation strategies.Results demonstrate that in renewable-dominant systems,deep regulation of thermal units,load peak-shaving,and deployment of flexible resources such as energy storage are effective in cutting carbon intensity.To achieve the defined targets—0.367 kg/kWh by 2030,0.231 kg/kWh by 2045,and 0.032 kg/kWh by 2060—the following innovation-focused policy is recommended:in early stage,mainly on expansion of renewable capacity and inter-provincial transmission infrastructure along with energy storage deployment;in mid-term,mainly on enhancement of electricity market mechanisms to promote green power trading and demand-side flexibility;and in late-stage,mainly on systematic retirement of conventional coal assets coupled with large-scale CCS adoption and carbon sink mechanisms.展开更多
The most common aspect of water conveyance tunnel construction is the use of horizontal and sub-horizontal exploration drilling of headings of a tunnel to predict geology and groundwater conditions.The instability of ...The most common aspect of water conveyance tunnel construction is the use of horizontal and sub-horizontal exploration drilling of headings of a tunnel to predict geology and groundwater conditions.The instability of boreholes,extreme loss of circulation,and high-head inflow are also common in fractured strata,which often inhibit completion of probe holes and the reliability of coring,packer testing,and grouting tests.Casing,consequently,is a significant enabling technology to stabilize fractured intervals and has a hydraulic isolation under coupled mechanical and hydrogeological disturbances.The review is a synthesis of research and engineering experience on methods of casing to be used in horizontal drilling of fractured rock masses used in the exploration of water conveyance tunnels.The geological and working environment is initially outlined with a focus on fracture-adaptable instability processes and the special goings on of underground drilling,such as the restricted workspace,cuttings difficult to move,and fast movement of the competent and crushed regions.Types of casing systems are then listed,including both standard threaded steel strings and telescopic programs,and more specialized casing system types,including expandable casing,swellable sealing elements,and external casing packers.Special focus is made on the sealing of annulus in horizontal holes,wherein slurry loss,gravity segregation,and non-uniform borehole geometry usually worsen isolation.Lastly,the article suggests adaptive choice of strategy according to real-time drilling reaction,and research priorities,such as tunnel-specific performance measurements,coupled hydro-mechanical modelling,and field trials of sophisticated sealing material and data-driven choice making.展开更多
The development of pattern-based traditional Chinese medicine(TCM)compound preparations constitutes a core domain that represents the principle of pattern differentiation-based treatment,a hallmark of TCM.However,the ...The development of pattern-based traditional Chinese medicine(TCM)compound preparations constitutes a core domain that represents the principle of pattern differentiation-based treatment,a hallmark of TCM.However,the field has long been constrained by scientific and regulatory challenges in animal modeling,efficacy evaluation,and clinical positioning.This article proposes a new research and development(R&D)paradigm strategically based on human use experience(HUE)and centered on the patient as the key to overcoming these bottlenecks and achieving high-quality progress.We systematically dissect the traditional problems in this field and demonstrate the pivotal role of high-quality HUE in enabling precise clinical positioning and optimizing R&D pathways(e.g.,applying for exemptions from non-clinical studies).HUE guides the implementation of the“pattern-symptom integration”model.Furthermore,we detail the implementation of the patient-centered concept throughout the process of clinical trial design,collection of patients’experience data,clinical outcome assessment,and benefit-risk assessment.The integrative application of artificial intelligence in the R&D of pattern-based TCM drugs is also specifically explored.By synthesizing the“TCM theory,HUE,and clinical trials”evidence system,this article aims to provide a systematic strategic framework for establishing an R&D pathway that adheres to the intrinsic principles of TCM while simultaneously meeting modern scientific standards.展开更多
With the growth of global protein demand and the development of plant-based foods,pea protein,as a low-allergenic,nutritionally balanced and environmentally friendly plant protein,has shown great potential in replacin...With the growth of global protein demand and the development of plant-based foods,pea protein,as a low-allergenic,nutritionally balanced and environmentally friendly plant protein,has shown great potential in replacing animal protein.Pea protein is mainly composed of globulin and albumin,with a protein content of 20%to 30%,and has a balanced amino acid composition,as well as being rich in minerals and dietary fiber.It also possesses good foaming,gelling,emulsifying and antioxidant functional properties.However,pea protein also has inherent defects that limit its application in the food industry.This article systematically reviews the extraction techniques,functional properties,modification methods and application fields of pea protein,and focuses on evaluating the effects of different extraction and modification strategies on protein yield and functional properties.Research shows that ultrasonic-assisted alkaline extraction can reduce solvent usage by 55%,shorten extraction time by 50%,and increase extraction rate by 12.51%;under optimized conditions,ultrafiltration membrane technology can achieve a protein purity of 91%.In terms of modification,ultrasonic treatment increases foaming capacity by 37.4%,and phenolic cross-linking increases gel strength from 3.0 kPa to 48 kPa.This article provides data support and theoretical reference for the efficient extraction and functional optimization of pea protein,and has promoting significance for its wide application in plant-based foods.展开更多
Background:Glioblastoma(GBM)prognosis has seen little improvement over the past two decades.While immunotherapy has revolutionized cancer treatment,its impact on GBM remains limited.To characterize the evolving resear...Background:Glioblastoma(GBM)prognosis has seen little improvement over the past two decades.While immunotherapy has revolutionized cancer treatment,its impact on GBM remains limited.To characterize the evolving research landscape and identify future directions in GBM immunotherapy,we conducted a comprehensive bibliometric review.Methods:All literature related to immunotherapy in GBM from 1999 to 2024 was collected from the Web of Science Core Collection.CtieSpace and VOSviewer were used to conduct bibliometric analysis and visualize the data.Results:Bibliometric analysis identified 5038 publications authored by 23,335 researchers from 4699 institutions across 96 countries/regions,published in 945 journals.The United States produced the highest number of publications,while Switzerland achieved the highest average citation rate.Duke University led in institutional output and citations.John H Sampson was the most productive author,and Roger Stupp was the most cited.Frontiers in Immunology published the most papers,while Clinical Cancer Research was the most cited journal.Research focus centered on adoptive T cell therapy,particularly chimeric antigen receptor(CAR)-T cells with 572 dedicated publications.Within CAR-T research for GBM,the University of Pennsylvania was the leading institution,Frontiers in Immunology the predominant journal,and Christine E Brown(City of Hope National Medical Center)was the most prolific and cited author.Conclusions:There has been a growing interest in GBM immunotherapy over past decades.The United States is the dominant contributor.CAR-T therapy represents the primary research focus.Emerging strategies like chimeric antigen receptor-modified natural killer(CAR-NK)cells,chimeric antigen receptor-engineered macrophages(CAR-M),and cytomegalovirus-specific T cell receptor(CMV-TCR)T cells are gaining prominence,aiming to address limitations in antigen recognition inherent to CAR-T therapy for GBM.展开更多
Purpose-With the deepening integration of rail transit systems-encompassing urban rail,regional railways,trunk lines and medium-low capacity transportation-the four-network integration imposes higher demands on operat...Purpose-With the deepening integration of rail transit systems-encompassing urban rail,regional railways,trunk lines and medium-low capacity transportation-the four-network integration imposes higher demands on operation and maintenance systems regarding cross-modal coordination,full-element interconnectivity and dynamic responsiveness.Design/methodology/approach-This paper,based on policy directives and engineering practices,analyzes the operational maintenance characteristics of urban rail traction systems from perspectives including device interconnectivity and fault data mining.A non-intrusive high-frequency diagnostic device independent of vehicle control is proposed,informed by practical onboard operation experience.This innovation significantly enhances diagnostic accuracy for components requiring high sampling frequency,while integrating“Flash”storage with far greater capacity than conventional control chips.Findings-This article will systematically introduces the key points and diagnostic methods for typical faults in urban rail traction systems.Through rational diagnostic algorithms combined with high-precision,highstorage diagnostic instrumentation,the overall safety and reliability of urban rail traction systems have been improved.The proposed non-intrusive high-frequency diagnostic solution has been validated across multiple rail lines.Originality/value-This paper introduces an innovative non-intrusive diagnostic device with a dual-channel design for multi-system compatibility and a high-speed acquisition architecture enabling 400 kHz sampling.Its originality stems from the independent,high-fidelity capture of microsecond-level transient faults like IGBT shoot-through and pantograph arcing;Validated in operational environments,this approach provides a significant leap in diagnostic precision,directly enhancing traction system availability and operational safety by enabling precise fault localization and intelligent,adaptive protection strategies.展开更多
Enzootic bovine leukosis(EBL)is a chronic lymphoproliferative disease caused by bovine leukemia virus(BLV),a retrovirus that establishes lifelong infection in cattle.While sustained surveillance and control programs h...Enzootic bovine leukosis(EBL)is a chronic lymphoproliferative disease caused by bovine leukemia virus(BLV),a retrovirus that establishes lifelong infection in cattle.While sustained surveillance and control programs have led to successful eradication in several European countries,BLV remains endemic across much of Asia,the Americas,and Africa.Infection is typically asymptomatic;however,a small proportion of infected animals develop malignant lymphoma,resulting in significant economic losses and animal welfare concerns.In Indonesia,understanding of BLV epidemiology remains notably limited.Existing data are derived primarily from small-scale or localized studies,providing an incomplete and fragmented picture of national prevalence and viral genetic diversity.Assessing BLV transmission dynamics is further complicated by the heterogeneous structure of Indonesia’s cattle industry,which is largely dominated by smallholder beef systems utilizing diverse indigenous breeds,alongside a more centralized and intensive dairy production sector.This paper synthesizes current knowledge on BLV biology and global epidemiological patterns,while critically evaluating the sparse evidence available from Indonesia.Key gaps are identified in risk factor characterization,molecular surveillance,and national-level monitoring frameworks.In the absence of effective vaccines,strengthening integrated and systematic surveillance systems is essential for informing evidence-based control strategies and developing a coherent national policy for BLV mitigation in Indonesia.展开更多
Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecul...Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecular mechanisms involved in these types of scars and developing effective treatments requires the use of controlled ex-perimental models,especially animals,to overcome the limitations of clinical studies.The aim of this sistematic review is to critically analyze the animal models used in the last five years(2020-2025)for the study of pathological scars,highlighting their advantages,limitations and applicability in the development of new therapeutic strat-egies.Murine,rabbit and porcine models,as well as alternative models,offer varied perspectives on the formation and treatment of HTS and KS,with an emphasis on histological and molecular correlations with human pathology.By synthesizing recent data,the paper highlights the essential role of preclinical research in optimizing an-tifibrotic treatments and in advancing the translation of data into the clinical sphere.Overall,animal models remain essential for bridging mechanistic insights with clinical translation,supporting the development of more effective and personalized anti-scar therapies.展开更多
基金Supported by the China National Science and Technology Major Project(2024ZD1405103)SINOPEC Science and Technology Major Project(P25184)。
文摘Centering on the critical bottlenecks in the development of shale oil in the Jiyang Depression of Shengli Oilfield,key scientific and engineering issues are proposed in aspects such as the storage space and occurrence state of shale oil,the formation mechanisms of multi-scale flow spaces,the mobilization mechanisms of crude oil in pores and fractures,and the enhanced oil recovery(EOR)mechanisms during the late stage of elastic development.The research progress and mechanistic insights in recent years are reviewed with respect to experimental techniques,characteristics of pore-fracture structure and fluid occurrence,fracture evolution mechanisms,shale oil flow mechanisms and EOR techniques.Through improving the experimental methods,optimizing the testing conditions,and developing new technologies,we deeply understand the occurrence state,storage space and flow pattern of shale oil,and reveal the distribution pattern of“oil-bearing in all pore sizes and oil-rich in large pores”and the differences in fluid phase states under the confinement effect of nano-scale pores in the shales of the Jiyang Depression;depict the characteristics of“restricted vertical expansion and complex fracture networks”of induced fractures and the dynamic evolution of fracture networks during the fracturing-soaking-production process;establish a“easy flow-slow flow-stagnant flow”three-zone model and the elastic drive+imbibition drive synergistic energy replenishment mechanism;and carry out high-pressure injection to further enhance the mass transfer and diffusion capacity of CO_(2)within the shale pore-fracture system,and compete for the desorption of alkanes to improve the mobilization degree of shale oil.The research achievements provide crucial support for the formation of the theory of continental shale oil development and the construction of the technical system.The future research efforts will focus on mine-scale multi-field coupling physical simulation equipment,microscopic to macroscopic multi-scale experimental methods,pore/fracture fine characterization and post-fracturing core fracture description technologies,multi-media fluid-structure coupling numerical simulation algorithms,and low-cost EOR and low-quality shale oil in-situ upgrading technologies,in order to promote the large-scale and profitable development of shale oil in the Jiyang Depression.
文摘In 2025,I had the honor of delivering keynote speeches at the conferences of the International Society for Diet and Activity Methods in Toronto,Canada,and the International Society of Behavioural Nutrition and Physical Activity in Auckland,Aotearoa,New Zealand.These opportunities prompted deep reflection on scientific research in general,and on physical activity and health research specifically.
文摘A soft X-ray energy materials research beamline(BL20U2),a branch of energy materials beamline(E-line),has been constructed in the Shanghai Synchrotron Radiation Facility(SSRF)Phase-Ⅱ project.It is now operational for soft X-ray resonant emission spectroscopy(RXES)and soft X-ray resonant elastic scattering(REXS)investigations.Optical optimization was implemented for high performance,e.g.,photon flux,energy-resolving power,and focus spot size.RXES experiments show that the energy range extends from 150 to 1500 eV.The elastic peak measured near titanium absorption edge(@445 eV)indicates an energy resolution of the RXES spectrometer of 65 meV.The measured photon flux is 3×10^(12)photons/s at 244 eV at the RXES sample position for an SSRF electron energy of 3.5 GeV and a projected ring current as 300 mA.The spot size at the RXES sample position is 23μm in the horizontal direction and 7.9μm in the vertical direction,respectively.Moreover,the angular resolution of elastic REXS scatterometer reaches 0.005°through measurement of X-ray reflection from the single-crystal silicon wafers.A sample of the REXS scatterometer is vibrationally decoupled from its chamber and cooled using copper braids connected from an open cycle liquid helium cryo reservoir,whereas the minimum sample temperature is below 15 K.
文摘Educational cooperation,as the cornerstone and vanguard of people-to-people exchanges and practical cooperation between China and Africa,holds irreplaceable strategic significance for enhancing the quality of Africa's human capital and accelerating its structural transformation and modernization process.This paper employs“demand–supply–adaptation”as its core analytical framework and aims to systematically explore how the educational cooperation between China and Africa can serve Africa's goal of modernization more precisely and effectively.First,through reviewing and analyzing the domestic and international research literature,this paper clarifies the focus,paradigms,and shortcomings of existing research,identifying the knowledge contribution of this study.Second,utilizing detailed macro-level data,case studies,and comparative research methods,it comprehensively presents the multidimensional status,structural characteristics,and development trends of China–Africa educational cooperation in areas such as student exchanges,cooperative education,vocational and technical training,language and cultural exchange,and emerging digital education.This paper also deeply analyzes the pressing and specific demands placed on the education system by Africa's modernization development across key dimensions like economic diversification,industrialization,agricultural modernization,social governance upgrading,and digital transformation.Third,based on the cooperative principle of“Africa's needs and China's strengths,”this paper innovatively proposes systematic countermeasures and suggestions for constructing new,multi-level,high-quality,sustainable,and future-oriented pathways for China–Africa educational cooperation:(a)promoting the strategic focus of cooperation to extend from“hard infrastructure”support to empowering“soft infrastructure”;(b)deepening the integration of industry and education and school–enterprise collaboration to precisely align with Africa's industrial development needs;vigorously developing digital education and jointly building a smart education ecosystem to help Africa bridge the digital divide;(c)improving an evidence-based,third-party evaluation system for cooperative effectiveness and a full-process quality assurance system;and(d)promoting the collaborative participation of multiple actors including governments,schools,enterprises,think tanks,and social organizations to build a new cooperative pattern of coconstruction,co-governance,and shared benefits.
基金supported by a grant from the National Science and Technology Major Project(Grant No.2024ZD0519800).
文摘Both large-scale prospective randomized controlled trials(RCTs)and smaller investigator-initiated trials are essential for evaluating the efficacy and safety of medical interventions.Robust protocols and statistical designs ensure the reliability of trial outcomes and improve the credibility of research findings.By reviewing the statistical approaches used in the TORCHLIGHT,NCC2167,and NeoTENNIS trials,this article illustrates the principles underlying large-sample confirmatory RCTs,small-sample exploratory adaptive designs,and single-arm two-stage designs.This discussion is aimed at helping researchers apply these design methods more effectively,to increase the likelihood of success in clinical studies.
文摘By 2025,research on Traditional Chinese Medicine(TCM)meridians has generated 12-15 macro-level theories and over 20 specific hypotheses,manifesting a highly fragmented research landscape.Objective:This paper proposes the“Holistic Hierarchical Predictive-Integration Hypothesis”(HHPIT)to construct a unified theoretical framework that integrates the rational components of existing meridian hypotheses.Methods:The HHPIT hypothesis systematically reviews current meridian theories,employs interdisciplinary methodologies,integrates artificial intelligence technology,and establishes a three-tier architecture encompassing structural,functional,and systemic layers.Results:HHPIT successfully integrates diverse meridian theories,proposes a computable algorithmic pipeline,and provides specific application protocols for chronic disease treatment,anti-aging,and enhancement of Zang-fu organ functions.Conclusion:HHPIT offers a novel,computable,and verifiable research paradigm for meridian studies,promoting the modernization and internationalization of TCM theory.
基金supported by the National Natural Science Foundation of China(32171022,32221005,and 32401246).
文摘While conventional FISH and IHC methods struggle to decode complex tissue heterogeneity and comprehensive molecular diagnosis due to low-throughput spatial information,spatial omics technologies enable high-throughput molecular mapping across tissue microenvironments.These technologies are emerging as transformative tools in molecular diagnostics and medical research.By integrating histopathological morphology with spatial multi-omics profiling(genome,transcriptome,epigenome,and proteome),spatial omics technologies open an avenue for understanding disease progression,therapeutic resistance mechanisms,and precise diagnosis.It particularly enhances tumor microenvironment analysis by mapping immune cell distributions and functional states,which may greatly facilitate tumor molecular subtyping,prognostic assessment,and prediction of the radiotherapy and chemotherapy efficacy.Despite the substantial advancements in spatial omics,the translation of spatial omics into clinical applications remains challenging due to robustness,efficacy,clinical validation,and cost constraints.In this review,we summarize the current progress and prospects of spatial omics technologies,particularly in medical research and diagnostic applications.
基金supported by the Natural Science Foundation of Anhui Province(2408085MC058 and 2308085QC91)National Natural Science Foundation of China(32301783and U21A20214)+5 种基金Innovation Program of the Chinese Academy of Agricultural Sciences(CAAS CSIAF-202303)Nanfan special project,CAAS(YYLH2309,YBXM2322,YYLH2401)Scientific Innovation 2030 Project(2022ZD0401703)CAAS Innovative Team Award,Science and Technology of Innovative research program of Anhui Province(202423m1005002)National Key Research and Development Program of China(2023YFD1200900)the Natural Science Foundation General Program of Hebei Province(C2024204242).
文摘IR64 is an elite Xian/indica variety developed by International Rice Research Institute(IRRl)in 1985,which has been the most widely grown variety and core breeding parent in South/Southeast Asia(Mackill and Khush,2018).IR64 has been utilized to develop stress-tolerant(such as drought-adapted and submergenceresistant)near-isogenic lines,underscoring its great potential in agricultural genomics(Tanaka et al.,2020).
基金Hunan Provincial Natural Science Foundation of China,Grant/Award Numbers:2024JJ6289,2023JJ60464,2023JJ60334Changsha City Technology Program,Grant/Award Number:kq2403120+1 种基金Climb Plan of Hunan Cancer Hospital,Grant/Award Numbers:ZX2021005,QH2023006High-Level Talent Support Program of Hunan Cancer Hospital,Grant/Award Number:20250731-1050。
文摘The convergence of artificial intelligence(AI)and big data is reshaping contemporary oncology by enabling the integration of multimodal information across imaging,pathology,genomics,and clinical records.From a physician-centered perspective,these technologies can potentially be used to improve diagnostic precision,support individualized treatment planning,enhance longitudinal patient management,and accelerate both clinical and translational research.In this review,we synthesize the core AI methodologies most relevant to oncology-machine learning,deep learning,and large language models-and examine how they interact with established and emerging oncology data platforms.We further highlight practical use cases in clinical workflows and research pipelines,emphasizing opportunities for advancing precision cancer care while also addressing challenges associated with data heterogeneity,model generalizability,privacy protection,and real-world implementation.By underscoring the synergistic value of AI and big data,this review aims to inform the development of clinically meaningful,context-adapted strategies that promote translational innovation in both global and locally resourced healthcare environments.
基金Northwest Institute of Nonferrous Metal Research Funding(YK2324)Key Research and Development Program of Shaanxi(2024GX-YBXM-403)National Natural Science Foundation of China(52277029)。
文摘High-entropy alloys,a novel class of materials characterized by the statistical distribution of multiple principal elements on simple crystalline lattices,have emerged as a research hotspot in materials science and condensed matter physics due to their exceptional mechanical properties and unique high-entropy characteristic.Since the discovery of the first high-entropy superconductor in 2014,exploring their superconducting performance and advantages has progressively become a frontier in scientific research.The Ta-Nb-Hf-Zr-Ti system,in particular,exhibits remarkable mechanical robustness,outstanding radiation tolerance,and superconducting performance comparable to the binary NbTi alloy,positioning it as a promising candidate for advanced applications,such as high-field superconducting magnets,superconducting electric motors,and next-generation nuclear fusion reactors.This review systematically summarized global research progress on Ta-Nb-Hf-Zr-Ti-based superconductors,aiming to provide a comprehensive reference for advancing this burgeoning field.
基金Supported by Innovation Capability Support Program of Shaanxi(2024RS-CXTD-53,2024ZC-KJXX-096)the Key R&D Program of Shaanxi Province(2022QCY-LL-69)Xi’an Science and Technology Project(24GXFW0089)。
文摘Under the backdrop of“Carbon Peak and Carbon Neutrality”(dual carbon)goal in China,the methane-carbon dioxide reforming reaction has attracted considerable attention due to its environmental benefits of converting two greenhouse gases(methane and carbon dioxide)into syngas and its promising industrial applications.Nickel(Ni)-based catalysts,with high catalytic activity,low cost,and abundant resources,are considered ideal candidates for industrial applications.In this article,three reaction kinetic models were briefly introduced,namely the Power-Law(PL)model,the Eley-Rideal(ER)model,and the Langmuir-Hinshelwood-Hougen-Watson(LHHW)model.Based on the LHHW model,the reaction kinetics and mechanisms of different catalytic systems were systematically discussed,including the properties of supports,the doping of noble metals and transition metals,the role of promoters,and the influence of the geometric and electronic structures of Ni on the reaction mechanism.Furthermore,the kinetics of carbon deposition and elimination on various catalysts were analyzed.Based on the reaction rate expressions for carbon elimination,the reasons for the high activity of transition metal iron(Fe)-doped catalysts and core-shell structured catalysts in carbon elimination were explained.Based on the detailed collation and comparative analysis of the reaction mechanisms and kinetic characteristics across diverse Ni-based catalytic systems,a theoretical guidance for the designing of high-performance catalysts was provided in this work.
基金Supported by Putuo District Science and Technology R&D Platform Project,Shanghai(2024QX04).
文摘[Objectives]To investigate the efficacy and potential mechanism of the topical preparation Jineijin-Shanzha Patch(composed of Galli Gigerii Endothelium Corneum and Crataegi Fructus)in improving functional dyspepsia(FD)based on network pharmacology.[Methods]Firstly,we reviewed the existing research progress on each constituent drug of the Jineijin Shanzha Patch for FD improvement.Following this,identified overlapping genes were utilized to construct both a"Drug-Active Component-FD Target"network and a Protein-Protein Interaction(PPI)network specific to the patch.In addition,Gene Ontology(GO)analysis was carried out.[Results]We identified that the 13 herbs in the Jineijin Shanzha Patch are mainly used for food stagnation,qi stagnation,and spleen deficiency.Screening revealed 43 active patch components,1414 FD-related targets,and 284 shared targets between them.The PPI network analysis further identified the top 10 core targets from these shared targets.From the"Drug-Active Component-FD Target"network,we identified the core elements.These included the herbal components Vignae Semen(from Liushenqu),Crataegi Fructus,and Pseudostellariae Radix;the active components quercetin,genistein,and apigenin;and the key targets CASP3,BCL2,and CASP9.GO analysis of the 284 overlapping targets indicated that the Jineijin Shanzha Patch may exert its therapeutic effects via regulation of biological processes such as the response to lipopolysaccharide,response to bacterium-derived molecules,and regulation of the apoptotic signaling pathway.[Conclusions]The main active components of the Jineijin Shanzha Patch(quercetin,genistein,and apigenin)may improve FD by modulating signaling pathways such as the response to lipopolysaccharide,response to bacterium-derived molecules,and regulation of the apoptotic signaling pathway,thereby acting on key targets including CASP3,BCL2,and CASP9.
基金supported by Science and Technology Project of China Southern Power Grid Co.,Ltd.(GDKJXM20231259).
文摘This paper develops an innovative computational model for assessing the Carbon Emission Factor(CEF)of provincial power systems that incorporates inter-provincial electricity transfers and hybrid generation portfolios combining conventional and renewable sources.A key contribution lies in evaluating how deep regulation of thermal power plants influence the carbon intensity of coal-fired generation and coal-fired generation together with high penetration renewables.Furthermore,the study quantitatively analyzes the role of renewable energy consumption and the prospective application of Carbon Capture and Storage(CCS)in reducing system-wide CEF.Based on this framework,the paper proposes phased carbon emission targets for Guangdong’s power system for key milestone years(2030,2045,2060),along with targeted implementation strategies.Results demonstrate that in renewable-dominant systems,deep regulation of thermal units,load peak-shaving,and deployment of flexible resources such as energy storage are effective in cutting carbon intensity.To achieve the defined targets—0.367 kg/kWh by 2030,0.231 kg/kWh by 2045,and 0.032 kg/kWh by 2060—the following innovation-focused policy is recommended:in early stage,mainly on expansion of renewable capacity and inter-provincial transmission infrastructure along with energy storage deployment;in mid-term,mainly on enhancement of electricity market mechanisms to promote green power trading and demand-side flexibility;and in late-stage,mainly on systematic retirement of conventional coal assets coupled with large-scale CCS adoption and carbon sink mechanisms.
文摘The most common aspect of water conveyance tunnel construction is the use of horizontal and sub-horizontal exploration drilling of headings of a tunnel to predict geology and groundwater conditions.The instability of boreholes,extreme loss of circulation,and high-head inflow are also common in fractured strata,which often inhibit completion of probe holes and the reliability of coring,packer testing,and grouting tests.Casing,consequently,is a significant enabling technology to stabilize fractured intervals and has a hydraulic isolation under coupled mechanical and hydrogeological disturbances.The review is a synthesis of research and engineering experience on methods of casing to be used in horizontal drilling of fractured rock masses used in the exploration of water conveyance tunnels.The geological and working environment is initially outlined with a focus on fracture-adaptable instability processes and the special goings on of underground drilling,such as the restricted workspace,cuttings difficult to move,and fast movement of the competent and crushed regions.Types of casing systems are then listed,including both standard threaded steel strings and telescopic programs,and more specialized casing system types,including expandable casing,swellable sealing elements,and external casing packers.Special focus is made on the sealing of annulus in horizontal holes,wherein slurry loss,gravity segregation,and non-uniform borehole geometry usually worsen isolation.Lastly,the article suggests adaptive choice of strategy according to real-time drilling reaction,and research priorities,such as tunnel-specific performance measurements,coupled hydro-mechanical modelling,and field trials of sophisticated sealing material and data-driven choice making.
基金supported by the Key Laboratory of Clinical Evaluation Technology for Human Experience with Chinese Medicine,Science and Technology Innovation Project of Guangdong Provincial Medical Products Administration(2022ZDB06)the Jointly Funded Project by Guangzhou Science and Technology Bureau,Research Institutes and Enterprises(2024A03j0355)+1 种基金the State Key Laboratory of Traditional Chinese Medicine Syndrome"Unveiling the List and Taking on Leadership"Project(SKLKY2025C0013)the National Key Research and Development Program of China(2025YFC3507902).
文摘The development of pattern-based traditional Chinese medicine(TCM)compound preparations constitutes a core domain that represents the principle of pattern differentiation-based treatment,a hallmark of TCM.However,the field has long been constrained by scientific and regulatory challenges in animal modeling,efficacy evaluation,and clinical positioning.This article proposes a new research and development(R&D)paradigm strategically based on human use experience(HUE)and centered on the patient as the key to overcoming these bottlenecks and achieving high-quality progress.We systematically dissect the traditional problems in this field and demonstrate the pivotal role of high-quality HUE in enabling precise clinical positioning and optimizing R&D pathways(e.g.,applying for exemptions from non-clinical studies).HUE guides the implementation of the“pattern-symptom integration”model.Furthermore,we detail the implementation of the patient-centered concept throughout the process of clinical trial design,collection of patients’experience data,clinical outcome assessment,and benefit-risk assessment.The integrative application of artificial intelligence in the R&D of pattern-based TCM drugs is also specifically explored.By synthesizing the“TCM theory,HUE,and clinical trials”evidence system,this article aims to provide a systematic strategic framework for establishing an R&D pathway that adheres to the intrinsic principles of TCM while simultaneously meeting modern scientific standards.
文摘With the growth of global protein demand and the development of plant-based foods,pea protein,as a low-allergenic,nutritionally balanced and environmentally friendly plant protein,has shown great potential in replacing animal protein.Pea protein is mainly composed of globulin and albumin,with a protein content of 20%to 30%,and has a balanced amino acid composition,as well as being rich in minerals and dietary fiber.It also possesses good foaming,gelling,emulsifying and antioxidant functional properties.However,pea protein also has inherent defects that limit its application in the food industry.This article systematically reviews the extraction techniques,functional properties,modification methods and application fields of pea protein,and focuses on evaluating the effects of different extraction and modification strategies on protein yield and functional properties.Research shows that ultrasonic-assisted alkaline extraction can reduce solvent usage by 55%,shorten extraction time by 50%,and increase extraction rate by 12.51%;under optimized conditions,ultrafiltration membrane technology can achieve a protein purity of 91%.In terms of modification,ultrasonic treatment increases foaming capacity by 37.4%,and phenolic cross-linking increases gel strength from 3.0 kPa to 48 kPa.This article provides data support and theoretical reference for the efficient extraction and functional optimization of pea protein,and has promoting significance for its wide application in plant-based foods.
基金supported by Key Research and Development Plan of Hunan Province(2024DK2006)the Fundamental Research Funds for the Central Universities of Central South University(1053320221769)+2 种基金Hunan Provincial Respiratory Disease Rehabilitation and Nursing Engineering Research Center Innovation Capacity Building Project(No.202012)the Zhangjiajie Science and Technology Development Key Special Project(No.202304)the National Key Clinical Specialty Major Scientific Research Project(No.20230382).
文摘Background:Glioblastoma(GBM)prognosis has seen little improvement over the past two decades.While immunotherapy has revolutionized cancer treatment,its impact on GBM remains limited.To characterize the evolving research landscape and identify future directions in GBM immunotherapy,we conducted a comprehensive bibliometric review.Methods:All literature related to immunotherapy in GBM from 1999 to 2024 was collected from the Web of Science Core Collection.CtieSpace and VOSviewer were used to conduct bibliometric analysis and visualize the data.Results:Bibliometric analysis identified 5038 publications authored by 23,335 researchers from 4699 institutions across 96 countries/regions,published in 945 journals.The United States produced the highest number of publications,while Switzerland achieved the highest average citation rate.Duke University led in institutional output and citations.John H Sampson was the most productive author,and Roger Stupp was the most cited.Frontiers in Immunology published the most papers,while Clinical Cancer Research was the most cited journal.Research focus centered on adoptive T cell therapy,particularly chimeric antigen receptor(CAR)-T cells with 572 dedicated publications.Within CAR-T research for GBM,the University of Pennsylvania was the leading institution,Frontiers in Immunology the predominant journal,and Christine E Brown(City of Hope National Medical Center)was the most prolific and cited author.Conclusions:There has been a growing interest in GBM immunotherapy over past decades.The United States is the dominant contributor.CAR-T therapy represents the primary research focus.Emerging strategies like chimeric antigen receptor-modified natural killer(CAR-NK)cells,chimeric antigen receptor-engineered macrophages(CAR-M),and cytomegalovirus-specific T cell receptor(CMV-TCR)T cells are gaining prominence,aiming to address limitations in antigen recognition inherent to CAR-T therapy for GBM.
基金supported by the Fund of China Academy of Railway Sciences Corporation Limited(2023YJ342).
文摘Purpose-With the deepening integration of rail transit systems-encompassing urban rail,regional railways,trunk lines and medium-low capacity transportation-the four-network integration imposes higher demands on operation and maintenance systems regarding cross-modal coordination,full-element interconnectivity and dynamic responsiveness.Design/methodology/approach-This paper,based on policy directives and engineering practices,analyzes the operational maintenance characteristics of urban rail traction systems from perspectives including device interconnectivity and fault data mining.A non-intrusive high-frequency diagnostic device independent of vehicle control is proposed,informed by practical onboard operation experience.This innovation significantly enhances diagnostic accuracy for components requiring high sampling frequency,while integrating“Flash”storage with far greater capacity than conventional control chips.Findings-This article will systematically introduces the key points and diagnostic methods for typical faults in urban rail traction systems.Through rational diagnostic algorithms combined with high-precision,highstorage diagnostic instrumentation,the overall safety and reliability of urban rail traction systems have been improved.The proposed non-intrusive high-frequency diagnostic solution has been validated across multiple rail lines.Originality/value-This paper introduces an innovative non-intrusive diagnostic device with a dual-channel design for multi-system compatibility and a high-speed acquisition architecture enabling 400 kHz sampling.Its originality stems from the independent,high-fidelity capture of microsecond-level transient faults like IGBT shoot-through and pantograph arcing;Validated in operational environments,this approach provides a significant leap in diagnostic precision,directly enhancing traction system availability and operational safety by enabling precise fault localization and intelligent,adaptive protection strategies.
基金funded by the Virtual Research Center for Bioinformatics and Biotechnology(VRCBB),Indonesia(Grant Number:RG/26/01).
文摘Enzootic bovine leukosis(EBL)is a chronic lymphoproliferative disease caused by bovine leukemia virus(BLV),a retrovirus that establishes lifelong infection in cattle.While sustained surveillance and control programs have led to successful eradication in several European countries,BLV remains endemic across much of Asia,the Americas,and Africa.Infection is typically asymptomatic;however,a small proportion of infected animals develop malignant lymphoma,resulting in significant economic losses and animal welfare concerns.In Indonesia,understanding of BLV epidemiology remains notably limited.Existing data are derived primarily from small-scale or localized studies,providing an incomplete and fragmented picture of national prevalence and viral genetic diversity.Assessing BLV transmission dynamics is further complicated by the heterogeneous structure of Indonesia’s cattle industry,which is largely dominated by smallholder beef systems utilizing diverse indigenous breeds,alongside a more centralized and intensive dairy production sector.This paper synthesizes current knowledge on BLV biology and global epidemiological patterns,while critically evaluating the sparse evidence available from Indonesia.Key gaps are identified in risk factor characterization,molecular surveillance,and national-level monitoring frameworks.In the absence of effective vaccines,strengthening integrated and systematic surveillance systems is essential for informing evidence-based control strategies and developing a coherent national policy for BLV mitigation in Indonesia.
基金Ministry of Research,Innovation and Digitization,CCCDI-UEFISCDI,Grant/Award Number:PN-IV-P7-7.1-PED-2024-1578,within PNCDI Ⅳ.
文摘Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecular mechanisms involved in these types of scars and developing effective treatments requires the use of controlled ex-perimental models,especially animals,to overcome the limitations of clinical studies.The aim of this sistematic review is to critically analyze the animal models used in the last five years(2020-2025)for the study of pathological scars,highlighting their advantages,limitations and applicability in the development of new therapeutic strat-egies.Murine,rabbit and porcine models,as well as alternative models,offer varied perspectives on the formation and treatment of HTS and KS,with an emphasis on histological and molecular correlations with human pathology.By synthesizing recent data,the paper highlights the essential role of preclinical research in optimizing an-tifibrotic treatments and in advancing the translation of data into the clinical sphere.Overall,animal models remain essential for bridging mechanistic insights with clinical translation,supporting the development of more effective and personalized anti-scar therapies.
