Tolnidamine (50 mg / kg body wt. / alternate day for 90 days; oral) was investigated for its contraceptive efficacy, causes of irreversibility, and side-effects by assessment of seminal characteristics and biochemistr...Tolnidamine (50 mg / kg body wt. / alternate day for 90 days; oral) was investigated for its contraceptive efficacy, causes of irreversibility, and side-effects by assessment of seminal characteristics and biochemistry, morphometry, libido and clinical investigations in adult male langur monkeys ( Presbytis entellus entellus Dufresne) . Semen weight, volume, colour, pH and libido remained unaltered. Sperm motility, vitality and morphology were impaired with the advancement of the treatment. Increased number of immature germ cells was also noted. Sperm density reduced to severe oligospermia following 45 days of treatment and remained low during recovery period. A marked reversible reduction in seminal GPC and magnesium levels was notieed, while other biachemical parameters remained unchanged. Irreversible changes in various morphometric data of Sertoli cells and spermatogonia were observed. Circulatory levels of testosterone fluctuated within pretreatment range. A significant but reversible elevation in serum creatinine was evident. The possible causes for irreversibility are the ever lasting alterations in the morphometry of Sertoli ceils and spermatogonia.展开更多
文摘Tolnidamine (50 mg / kg body wt. / alternate day for 90 days; oral) was investigated for its contraceptive efficacy, causes of irreversibility, and side-effects by assessment of seminal characteristics and biochemistry, morphometry, libido and clinical investigations in adult male langur monkeys ( Presbytis entellus entellus Dufresne) . Semen weight, volume, colour, pH and libido remained unaltered. Sperm motility, vitality and morphology were impaired with the advancement of the treatment. Increased number of immature germ cells was also noted. Sperm density reduced to severe oligospermia following 45 days of treatment and remained low during recovery period. A marked reversible reduction in seminal GPC and magnesium levels was notieed, while other biachemical parameters remained unchanged. Irreversible changes in various morphometric data of Sertoli cells and spermatogonia were observed. Circulatory levels of testosterone fluctuated within pretreatment range. A significant but reversible elevation in serum creatinine was evident. The possible causes for irreversibility are the ever lasting alterations in the morphometry of Sertoli ceils and spermatogonia.
