Fertilisation in mammals involves many synchronized steps including spermegg adhesion. Prior to sperm-oolemma fusion, spermatozoa need to undergo the acrosome reaction （AR） or exocytosis. The universal belief, for ...Fertilisation in mammals involves many synchronized steps including spermegg adhesion. Prior to sperm-oolemma fusion, spermatozoa need to undergo the acrosome reaction （AR） or exocytosis. The universal belief, for many years, has been that the AR was initiated upon binding to the zona pellucida （ZP）. As such acrosomal proteins were not thought to be involved in the primary contact with the ZP. These proteins were only suggested to be biologically relevant once the sperm were attached to the ZP and during subsequent events. However,展开更多
Zearalenone(ZEA)is produced by Fusarium species and a common contaminant in food.ZEA and its metabolites,α-andβ-zearalenol,α-andβ-zearalanol,and zearalanone,are mycoestrogens that can interfere with estrogen signa...Zearalenone(ZEA)is produced by Fusarium species and a common contaminant in food.ZEA and its metabolites,α-andβ-zearalenol,α-andβ-zearalanol,and zearalanone,are mycoestrogens that can interfere with estrogen signaling.High levels of mycoestrogens reduced female fertility in farm animals and rodents,in which adverse effects of mycoestrogens on major events in female reproduction,including ovarian folliculogenesis,ovulation,ovarian steroidogenesis,fertilization,preimplantation embryo development and transport,embryo implantation,placentation,parturition,and lactation,have been reported in different experimental settings.Here,we review the in vivo effects of mycoestrogens on the main events in female reproduction.展开更多
文摘Fertilisation in mammals involves many synchronized steps including spermegg adhesion. Prior to sperm-oolemma fusion, spermatozoa need to undergo the acrosome reaction （AR） or exocytosis. The universal belief, for many years, has been that the AR was initiated upon binding to the zona pellucida （ZP）. As such acrosomal proteins were not thought to be involved in the primary contact with the ZP. These proteins were only suggested to be biologically relevant once the sperm were attached to the ZP and during subsequent events. However,
基金the National Institutes of Health(NIH R01HD065939[co-funded by ORWH and NICHD]to XY)for financial support in the form of assistantship and grant support.
文摘Zearalenone(ZEA)is produced by Fusarium species and a common contaminant in food.ZEA and its metabolites,α-andβ-zearalenol,α-andβ-zearalanol,and zearalanone,are mycoestrogens that can interfere with estrogen signaling.High levels of mycoestrogens reduced female fertility in farm animals and rodents,in which adverse effects of mycoestrogens on major events in female reproduction,including ovarian folliculogenesis,ovulation,ovarian steroidogenesis,fertilization,preimplantation embryo development and transport,embryo implantation,placentation,parturition,and lactation,have been reported in different experimental settings.Here,we review the in vivo effects of mycoestrogens on the main events in female reproduction.
