Traumatic injuries to the central nervous system(CNS) result in disruption of the intricate network of axons which connect functionally related neurons that are widely distributed throughout the brain and spinal cord....Traumatic injuries to the central nervous system(CNS) result in disruption of the intricate network of axons which connect functionally related neurons that are widely distributed throughout the brain and spinal cord.Under normal conditions,maintenance of this complex system is structurally and functionally supported by astrocytes (ACs)and other glial cells,the processes of which form a framework surrounding neuronal cell bodies,dendrites,axons,and synapses.展开更多
Developing sensorless techniques for estimating battery expansion is essential for effective mechanical state monitoring,improving the accuracy of digital twin simulation and abnormality detection.Therefore,this paper...Developing sensorless techniques for estimating battery expansion is essential for effective mechanical state monitoring,improving the accuracy of digital twin simulation and abnormality detection.Therefore,this paper presents a data-driven approach to expansion estimation using electromechanical coupled models with machine learning.The proposed method integrates reduced-order impedance models with data-driven mechanical models,coupling the electrochemical and mechanical states through the state of charge(SOC)and mechanical pressure within a state estimation framework.The coupling relationship was established through experimental insights into pressure-related impedance parameters and the nonlinear mechanical behavior with SOC and pressure.The data-driven model was interpreted by introducing a novel swelling coefficient defined by component stiffnesses to capture the nonlinear mechanical behavior across various mechanical constraints.Sensitivity analysis of the impedance model shows that updating model parameters with pressure can reduce the mean absolute error of simulated voltage by 20 mV and SOC estimation error by 2%.The results demonstrate the model's estimation capabilities,achieving a root mean square error of less than 1 kPa when the maximum expansion force is from 30 kPa to 120 kPa,outperforming calibrated stiffness models and other machine learning techniques.The model's robustness and generalizability are further supported by its effective handling of SOC estimation and pressure measurement errors.This work highlights the importance of the proposed framework in enhancing state estimation and fault diagnosis for lithium-ion batteries.展开更多
Phosphorus(P)poses a global challenge to the environment and human health due to its natural association with heavy metals.Sustainable use of P is crucial to ensure food security for future generations.An analysis of ...Phosphorus(P)poses a global challenge to the environment and human health due to its natural association with heavy metals.Sustainable use of P is crucial to ensure food security for future generations.An analysis of the 150 phosphate fertilizers stored at the Institute for Crop and Soil Science in Germany has been conducted,supplemented by previously published data.The elements Cd,Bi,U,Cr,Zn,Tl,As,B,Sb,Ni,and Se are found in higher concentrations in sedimentary derived phosphates compared to igneous derived phosphates.Mineral fertilizers contain more than ten times the amount of U,Cd,B,and As compared to farmyard manure.Principal component analyses(PCA)indicate that U,Cd,Be,and Cr are primarily present in sedimentary derived phosphates and their concentrations are 2 to 10 times higher than those in igneous derived phosphates.Regarding heavy metal contamination,over 1000 potential combinations were identified;36% of these were significant but weak(>0.1).It is estimated that approximately 707 t of uranium enter farmland annually through the application of mineral phosphate fertilizers in European countries.This contribution addresses environmental issues related to the utilization of rock phosphate as well as alternative production methods for cleaner and safer phosphate fertilizers while presenting a roadmap with measures for mitigation.展开更多
BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related disorders.Recent evidence suggests associations between long-term...BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related disorders.Recent evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes,including greater mortality.AIM To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize bias.METHODS This retrospective cohort study used data from the TriNetX research network,with electronic health records from multiple healthcare organizations.The study employed a new-user,active comparator design,which compared newly treated PPI users with non-users and newly treated histamine2 receptor antagonists(H2RA)users among adult cancer patients.Newly prescribed PPIs(esomeprazole,lansoprazole,omeprazole,pantoprazole,or rabeprazole)users were compared to non-users or newly prescribed H2RAs(cimetidine,famotidine,nizatidine,or ranitidine)users.The primary outcome was all-cause mortality.Each patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding effects.Multivariable Cox regression models were used to estimate hazard ratios(HRs)and 95% confidence interval(CI).RESULTS During the follow-up period(median 5.4±1.8 years for PPI users and 6.5±1.0 years for non-users),PPI users demonstrated a higher all-cause mortality rate than non-users after 1 year,2 years,and at the end of follow up(HRs:2.34-2.72).Compared with H2RA users,PPI users demonstrated a higher rate of all-cause mortality HR:1.51(95%CI:1.41-1.69).Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure,confirming the robustness of these findings.In a sensitivity analysis,we analyzed all-cause mortality outcomes between former PPI users and individuals who have never used PPIs,providing insights into the long-term effects of past PPI use.In addition,at 1-year follow-up,the analysis revealed a significant difference in mortality rates between former PPI users and non-users(HR:1.84;95%CI:1.82-1.96).CONCLUSION PPI use among cancer patients was associated with a higher risk of all-cause mortality compared to non-users or H2RA users.These findings emphasize the need for cautious use of PPIs in cancer patients and suggest that alternative treatments should be considered when clinically feasible.However,further studies are needed to corroborate our findings,given the significant adverse outcomes in cancer patients.展开更多
Retrogressive landslides in sensitive clays pose significant risks to nearby infrastructure,as natural toe erosion or localized disturbances can trigger progressive block failures.While prior studies have largely reli...Retrogressive landslides in sensitive clays pose significant risks to nearby infrastructure,as natural toe erosion or localized disturbances can trigger progressive block failures.While prior studies have largely relied on two-dimensional(2D)large-deformation analyses,such models overlook key three-dimensional(3D)failure mechanisms and variability effects.This study develops a 3D probabilistic framework by integrating the Coupled Eulerian–Lagrangian(CEL)method with random field theory to simulate retrogressive landslides in spatially variable clay.Using Monte Carlo simulations,we compare 2D and 3D random large-deformation models to evaluate failure modes,runout distances,sliding velocities,and influence zones.The 3D analyses captured more complex failure modes—such as lateral retrogression and asynchronous block mobilization across slope width.Additionally,the 3D analyses predict longer mean runout distances(13.76 vs.11.92 m),wider mean influence distance(11.35 vs.8.73 m),and higher mean sliding velocities(4.66 vs.3.94 m/s)than their 2D counterparts.Moreover,3D models exhibit lower coefficients of variation(e.g.,0.10 for runout distance)due to spatial averaging across slope width.Probabilistic hazard assessment shows that 2D models significantly underpredict near-field failure probabilities(e.g.,48.8%vs.89.9%at 12 m from the slope toe).These findings highlight the limitations of 2D analyses and the importance of multi-directional spatial variability for robust geohazard assessments.The proposed 3D framework enables more realistic prediction of landslide mobility and supports the design of safer,risk-informed infrastructure.展开更多
In this study,the wave motion in elastodynamics for unbounded media is modeled using an unsplit-field perfectly matched layer(PML)formulation that is solved by employing an isogeometric analysis(IGA).In the adopted co...In this study,the wave motion in elastodynamics for unbounded media is modeled using an unsplit-field perfectly matched layer(PML)formulation that is solved by employing an isogeometric analysis(IGA).In the adopted combination,the non-uniform rational B-spline(NURBS)functions are employed as basis functions.Moreover,the unbounded and artificial domains,defined in the PML method,are contained in a single patch domain.Based on the proposed scheme,the approximation of the geometry problem is set in a new scheme in which the PML’s absorbing and attenuation properties and the description of traveling waves can be represented.This includes a higher continuity and smoother approximation of the computed domain.As high-order NURBS basis functions are non-interpolatory,a penalty method is present to apply a time-dependent displacement load.The performance of the NURBS-based PML is analyzed through numerical examples for 1D and 2D domains,considering homogeneous and heterogeneous media.Further,we verify the long-time numerical stability of the present method.The developed method can be used to simulate hypothetical stratified domains commonly encountered in soil-structure interaction analyses.展开更多
Scientific reforms proposed in response to moral concerns about corrupted science are reminiscent of the Christian Reformation,which similarly formed a moral reorientation as a reaction to malpractices.In this study,w...Scientific reforms proposed in response to moral concerns about corrupted science are reminiscent of the Christian Reformation,which similarly formed a moral reorientation as a reaction to malpractices.In this study,we compare these moral reorientation processes to contextualize two different moral programmes of the scientific reform movement and their sociopolitical conditions.We argue that such an explication of moral programmes is vital to build legitimacy and reflect on value-prioritization.While epistemic programmes are foregrounded,moral programmes also play a crucial role in shaping science,and different moral programmes offer different promises for the sustained support of credible,reliable,fair and equitable science.We discuss the virtue and equity programmes,and through interrogating both programmes in relation to the Reformation,we display the relevance of sociopolitical contexts to how key values operate in science and generate orders of worth.These insights aim to stimulate debate about the conditions for opting for either of these moral programmes.In our view,not all moral programmes offer equal promise for the sustained support of credible,equitable and fair science.展开更多
Dynamic recrystallization(DRX)in inhomogeneous deformation zones,such as grain boundaries,shear bands,and deformation bands,is critical for texture modification in magnesium alloys during deformation at elevated temper...Dynamic recrystallization(DRX)in inhomogeneous deformation zones,such as grain boundaries,shear bands,and deformation bands,is critical for texture modification in magnesium alloys during deformation at elevated temperatures.This study investigates the DRX mechanisms in AZWX3100 magnesium alloy under plane strain compression at 200℃.Microstructural analysis revealed necklace-type DRX accompanied by evidence of local grain boundary bulging.Additionally,ribbons of recrystallized grains were observed withinfine deformation bands,aligned with theoretical pyramidal I and II slip traces derived from the matrix.The distribution of local misorientation within the deformed microstructure demonstrated a clear association between deformation bands and localized strain.Dislocation analysis of lamellar specimens extracted from two pyramidal slip bands revealed<c+a>dislocations,indicating a connection between<c+a>slip activation and the formation of deformation bands.Crystal plasticity simulations suggest that the orientation of deformation bands is responsible for the unique recrystallization texture of the DRX grains within these bands.The texture characteristics imply a progressive,glide-induced DRX mechanism.A fundamental understanding of the role of deformation bands in texture modification can facilitate future alloy and process design.展开更多
BACKGROUND:As disasters intensify and professional deficits persist,civil protection is reliant on medical volunteers.With limited physician availability,telemedicine is promising.No system currently empowers lower-qu...BACKGROUND:As disasters intensify and professional deficits persist,civil protection is reliant on medical volunteers.With limited physician availability,telemedicine is promising.No system currently empowers lower-qualified paramedics for physician-delegated telemedicine.Existing telemedicine technology unfits for civil protection.This study aimed to evaluate a modified system at a music festival to simulate disaster situations.METHODS:A tablet-based telemedicine system,integrating vital sign monitoring,was deployed at the "Summerjam" music festival characterized by various medical emergencies.A physician could be contacted via telemedicine or requested onsite.Medical feasibility was rated by patient condition changes,with National Advisory Committee of Aeronautics(NACA) score and Primary Ranking for Initial Orientation in the Rescue service(PRIOR) algorithm for triaging.Technical feasibility was assessed by connection stability,communication,and vital sign transmission.RESULTS:Of 404 treatments,34(8.4%) were performed using telemedicine,49(12.1%) were carried out with a physician onsite.Telemedicine treatments accounted for 40.9% of all treatment in which a physician was involved.Patient conditions varied up to NACA III(moderate disturbance).A variety of internal medical(76.5%) and surgical(23.5%) conditions were addressed,some of which required invasive measures or application of medication.No patients experienced a deterioration in their condition.Despite technical difficulties,treatment was not significantly impacted,confirming technical feasibility.CONCLUSION:The study shows that lower-qualified paramedics can effectively use telemedicine for physician-delegated treatment,suggesting potential applicability to civil protection.Nonetheless,further system robustness improvements and research are needed.展开更多
The global demand for in vitro respiratory airway models has surged due to the coronavirus disease 2019(COVID-19)pandemic.Current state-of-the-art models use polymer membranes to separate epithelial cells from other c...The global demand for in vitro respiratory airway models has surged due to the coronavirus disease 2019(COVID-19)pandemic.Current state-of-the-art models use polymer membranes to separate epithelial cells from other cell types,creating a nonphysiological barrier.In this study,we applied three-dimensional(3D)printing and bioprinting to develop an in vitro model where endothelial and epithelial cells were in direct contact,mimicking their natural arrangement.This proof-ofconcept model includes a culture chamber,with an endothelial bioink printed and perfused through an epithelial channel.In silico simulations of the air velocity within the channel revealed shear stress values ranging from 0.13 to 0.39 Pa,aligning with the desired in vivo shear stress observed in the bronchi regions(0.1–0.4 Pa).Biomechanical movements during resting breathing were mimicked by incorporating a textile mesh positioned away from the cell–cell interface.The epithelial channel demonstrated a capacity for compression and expansion of up to−14.7%and+6.4%,respectively.Microscopic images showed that the epithelial cells formed a uniform monolayer within the lumen of the channel close to the bioprinted endothelial cells.Our novel model offers a valuable tool for future research into respiratory diseases and potential treatments under conditions closely mimicking those in the lung.展开更多
The electro-hydrostatic actuator(EHA)pump is required to operate in a wide range of pressures and speeds to meet the variable output power demands.However,the reliable operation range of EHA pumps is restricted,and th...The electro-hydrostatic actuator(EHA)pump is required to operate in a wide range of pressures and speeds to meet the variable output power demands.However,the reliable operation range of EHA pumps is restricted,and the cylinder block tilting is considered a serious factor.This paper presents an analytical approach for evaluating the critical operation range of EHA pumps based on a criterion for cylinder tilting states.It explicitly reveals the fundamental principle of the cylinder block tilting limiting the operation range.The criterion is verified with the measured tilting angle and leakage flow.Results show that the calculated critical conditions accurately identify the inflection point of performance changes.Beyond the critical operation range,the severe cylinder block tilting leads to a sharp increase in leakage and may even result in a sudden failure.Furthermore,the impacts of the center spring force,the piston-slipper assembly mass,and the position of the spline reaction on the critical operation range are investigated.展开更多
文摘Traumatic injuries to the central nervous system(CNS) result in disruption of the intricate network of axons which connect functionally related neurons that are widely distributed throughout the brain and spinal cord.Under normal conditions,maintenance of this complex system is structurally and functionally supported by astrocytes (ACs)and other glial cells,the processes of which form a framework surrounding neuronal cell bodies,dendrites,axons,and synapses.
基金Fund supported this work for Excellent Youth Scholars of China(Grant No.52222708)the National Natural Science Foundation of China(Grant No.51977007)+1 种基金Part of this work is supported by the research project“SPEED”(03XP0585)at RWTH Aachen Universityfunded by the German Federal Ministry of Education and Research(BMBF)。
文摘Developing sensorless techniques for estimating battery expansion is essential for effective mechanical state monitoring,improving the accuracy of digital twin simulation and abnormality detection.Therefore,this paper presents a data-driven approach to expansion estimation using electromechanical coupled models with machine learning.The proposed method integrates reduced-order impedance models with data-driven mechanical models,coupling the electrochemical and mechanical states through the state of charge(SOC)and mechanical pressure within a state estimation framework.The coupling relationship was established through experimental insights into pressure-related impedance parameters and the nonlinear mechanical behavior with SOC and pressure.The data-driven model was interpreted by introducing a novel swelling coefficient defined by component stiffnesses to capture the nonlinear mechanical behavior across various mechanical constraints.Sensitivity analysis of the impedance model shows that updating model parameters with pressure can reduce the mean absolute error of simulated voltage by 20 mV and SOC estimation error by 2%.The results demonstrate the model's estimation capabilities,achieving a root mean square error of less than 1 kPa when the maximum expansion force is from 30 kPa to 120 kPa,outperforming calibrated stiffness models and other machine learning techniques.The model's robustness and generalizability are further supported by its effective handling of SOC estimation and pressure measurement errors.This work highlights the importance of the proposed framework in enhancing state estimation and fault diagnosis for lithium-ion batteries.
基金funded by the Project of Yunnan Province’s Xingdian Talents Support Program(yfgrc202437)the Project of the International Cooperation Science Program of National Natural Science Foundation of China(42361144885).
文摘Phosphorus(P)poses a global challenge to the environment and human health due to its natural association with heavy metals.Sustainable use of P is crucial to ensure food security for future generations.An analysis of the 150 phosphate fertilizers stored at the Institute for Crop and Soil Science in Germany has been conducted,supplemented by previously published data.The elements Cd,Bi,U,Cr,Zn,Tl,As,B,Sb,Ni,and Se are found in higher concentrations in sedimentary derived phosphates compared to igneous derived phosphates.Mineral fertilizers contain more than ten times the amount of U,Cd,B,and As compared to farmyard manure.Principal component analyses(PCA)indicate that U,Cd,Be,and Cr are primarily present in sedimentary derived phosphates and their concentrations are 2 to 10 times higher than those in igneous derived phosphates.Regarding heavy metal contamination,over 1000 potential combinations were identified;36% of these were significant but weak(>0.1).It is estimated that approximately 707 t of uranium enter farmland annually through the application of mineral phosphate fertilizers in European countries.This contribution addresses environmental issues related to the utilization of rock phosphate as well as alternative production methods for cleaner and safer phosphate fertilizers while presenting a roadmap with measures for mitigation.
文摘BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related disorders.Recent evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes,including greater mortality.AIM To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize bias.METHODS This retrospective cohort study used data from the TriNetX research network,with electronic health records from multiple healthcare organizations.The study employed a new-user,active comparator design,which compared newly treated PPI users with non-users and newly treated histamine2 receptor antagonists(H2RA)users among adult cancer patients.Newly prescribed PPIs(esomeprazole,lansoprazole,omeprazole,pantoprazole,or rabeprazole)users were compared to non-users or newly prescribed H2RAs(cimetidine,famotidine,nizatidine,or ranitidine)users.The primary outcome was all-cause mortality.Each patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding effects.Multivariable Cox regression models were used to estimate hazard ratios(HRs)and 95% confidence interval(CI).RESULTS During the follow-up period(median 5.4±1.8 years for PPI users and 6.5±1.0 years for non-users),PPI users demonstrated a higher all-cause mortality rate than non-users after 1 year,2 years,and at the end of follow up(HRs:2.34-2.72).Compared with H2RA users,PPI users demonstrated a higher rate of all-cause mortality HR:1.51(95%CI:1.41-1.69).Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure,confirming the robustness of these findings.In a sensitivity analysis,we analyzed all-cause mortality outcomes between former PPI users and individuals who have never used PPIs,providing insights into the long-term effects of past PPI use.In addition,at 1-year follow-up,the analysis revealed a significant difference in mortality rates between former PPI users and non-users(HR:1.84;95%CI:1.82-1.96).CONCLUSION PPI use among cancer patients was associated with a higher risk of all-cause mortality compared to non-users or H2RA users.These findings emphasize the need for cautious use of PPIs in cancer patients and suggest that alternative treatments should be considered when clinically feasible.However,further studies are needed to corroborate our findings,given the significant adverse outcomes in cancer patients.
基金supported by the National Key Research and Development Program of China(No.2024YFC2815400)the European Commission(Nos.HORIZON MSCA-2024-PF-01 and 101200637)+2 种基金the Opening Fund of the State Key Laboratory of Water Resources Engineering and Management at Wuhan University(No.2024SGG07)the Shandong Provincial Natural Science Foundation(No.ZR2025MS647)the Sand Hazards and Opportunities for Resilience,Energy,and Sustainability(SHORES)Center,funded by Tamkeen under the NYUAD Research Institute Award CG013.
文摘Retrogressive landslides in sensitive clays pose significant risks to nearby infrastructure,as natural toe erosion or localized disturbances can trigger progressive block failures.While prior studies have largely relied on two-dimensional(2D)large-deformation analyses,such models overlook key three-dimensional(3D)failure mechanisms and variability effects.This study develops a 3D probabilistic framework by integrating the Coupled Eulerian–Lagrangian(CEL)method with random field theory to simulate retrogressive landslides in spatially variable clay.Using Monte Carlo simulations,we compare 2D and 3D random large-deformation models to evaluate failure modes,runout distances,sliding velocities,and influence zones.The 3D analyses captured more complex failure modes—such as lateral retrogression and asynchronous block mobilization across slope width.Additionally,the 3D analyses predict longer mean runout distances(13.76 vs.11.92 m),wider mean influence distance(11.35 vs.8.73 m),and higher mean sliding velocities(4.66 vs.3.94 m/s)than their 2D counterparts.Moreover,3D models exhibit lower coefficients of variation(e.g.,0.10 for runout distance)due to spatial averaging across slope width.Probabilistic hazard assessment shows that 2D models significantly underpredict near-field failure probabilities(e.g.,48.8%vs.89.9%at 12 m from the slope toe).These findings highlight the limitations of 2D analyses and the importance of multi-directional spatial variability for robust geohazard assessments.The proposed 3D framework enables more realistic prediction of landslide mobility and supports the design of safer,risk-informed infrastructure.
文摘In this study,the wave motion in elastodynamics for unbounded media is modeled using an unsplit-field perfectly matched layer(PML)formulation that is solved by employing an isogeometric analysis(IGA).In the adopted combination,the non-uniform rational B-spline(NURBS)functions are employed as basis functions.Moreover,the unbounded and artificial domains,defined in the PML method,are contained in a single patch domain.Based on the proposed scheme,the approximation of the geometry problem is set in a new scheme in which the PML’s absorbing and attenuation properties and the description of traveling waves can be represented.This includes a higher continuity and smoother approximation of the computed domain.As high-order NURBS basis functions are non-interpolatory,a penalty method is present to apply a time-dependent displacement load.The performance of the NURBS-based PML is analyzed through numerical examples for 1D and 2D domains,considering homogeneous and heterogeneous media.Further,we verify the long-time numerical stability of the present method.The developed method can be used to simulate hypothetical stratified domains commonly encountered in soil-structure interaction analyses.
基金supported by the German Federal Ministry of Education and Research(BMBF)through their award of the K?te Hamburger Kolleg‘Cultures of Research’Senior Research Fellowship to Bart Penders
文摘Scientific reforms proposed in response to moral concerns about corrupted science are reminiscent of the Christian Reformation,which similarly formed a moral reorientation as a reaction to malpractices.In this study,we compare these moral reorientation processes to contextualize two different moral programmes of the scientific reform movement and their sociopolitical conditions.We argue that such an explication of moral programmes is vital to build legitimacy and reflect on value-prioritization.While epistemic programmes are foregrounded,moral programmes also play a crucial role in shaping science,and different moral programmes offer different promises for the sustained support of credible,reliable,fair and equitable science.We discuss the virtue and equity programmes,and through interrogating both programmes in relation to the Reformation,we display the relevance of sociopolitical contexts to how key values operate in science and generate orders of worth.These insights aim to stimulate debate about the conditions for opting for either of these moral programmes.In our view,not all moral programmes offer equal promise for the sustained support of credible,equitable and fair science.
基金by the Deutsche Forschungsgemeinschaft(DFG)through projects 420149269,394480829as part of the CRC1394“Structural and Chemical Atomic Complexity-From Defect Phase Diagrams to Material Properties”(project 409476157).
文摘Dynamic recrystallization(DRX)in inhomogeneous deformation zones,such as grain boundaries,shear bands,and deformation bands,is critical for texture modification in magnesium alloys during deformation at elevated temperatures.This study investigates the DRX mechanisms in AZWX3100 magnesium alloy under plane strain compression at 200℃.Microstructural analysis revealed necklace-type DRX accompanied by evidence of local grain boundary bulging.Additionally,ribbons of recrystallized grains were observed withinfine deformation bands,aligned with theoretical pyramidal I and II slip traces derived from the matrix.The distribution of local misorientation within the deformed microstructure demonstrated a clear association between deformation bands and localized strain.Dislocation analysis of lamellar specimens extracted from two pyramidal slip bands revealed<c+a>dislocations,indicating a connection between<c+a>slip activation and the formation of deformation bands.Crystal plasticity simulations suggest that the orientation of deformation bands is responsible for the unique recrystallization texture of the DRX grains within these bands.The texture characteristics imply a progressive,glide-induced DRX mechanism.A fundamental understanding of the role of deformation bands in texture modification can facilitate future alloy and process design.
基金funded by the German Federal Office of Civil Protection and Disaster Assistance as part of the Tele SAN project (FKZ:41201/425)。
文摘BACKGROUND:As disasters intensify and professional deficits persist,civil protection is reliant on medical volunteers.With limited physician availability,telemedicine is promising.No system currently empowers lower-qualified paramedics for physician-delegated telemedicine.Existing telemedicine technology unfits for civil protection.This study aimed to evaluate a modified system at a music festival to simulate disaster situations.METHODS:A tablet-based telemedicine system,integrating vital sign monitoring,was deployed at the "Summerjam" music festival characterized by various medical emergencies.A physician could be contacted via telemedicine or requested onsite.Medical feasibility was rated by patient condition changes,with National Advisory Committee of Aeronautics(NACA) score and Primary Ranking for Initial Orientation in the Rescue service(PRIOR) algorithm for triaging.Technical feasibility was assessed by connection stability,communication,and vital sign transmission.RESULTS:Of 404 treatments,34(8.4%) were performed using telemedicine,49(12.1%) were carried out with a physician onsite.Telemedicine treatments accounted for 40.9% of all treatment in which a physician was involved.Patient conditions varied up to NACA III(moderate disturbance).A variety of internal medical(76.5%) and surgical(23.5%) conditions were addressed,some of which required invasive measures or application of medication.No patients experienced a deterioration in their condition.Despite technical difficulties,treatment was not significantly impacted,confirming technical feasibility.CONCLUSION:The study shows that lower-qualified paramedics can effectively use telemedicine for physician-delegated treatment,suggesting potential applicability to civil protection.Nonetheless,further system robustness improvements and research are needed.
基金supported by the Volkswagen Foundation(Grant No.Az 99078 to DDC,ALT,and MT)funded by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)under Germany’s Excellence Strategy–2082/1–390761711(to DDC)part of the research training group GRK 2415–Mechanobiology in Epithelial 3D Tissue Constructs(project number 363055819,to ALT and SJ).
文摘The global demand for in vitro respiratory airway models has surged due to the coronavirus disease 2019(COVID-19)pandemic.Current state-of-the-art models use polymer membranes to separate epithelial cells from other cell types,creating a nonphysiological barrier.In this study,we applied three-dimensional(3D)printing and bioprinting to develop an in vitro model where endothelial and epithelial cells were in direct contact,mimicking their natural arrangement.This proof-ofconcept model includes a culture chamber,with an endothelial bioink printed and perfused through an epithelial channel.In silico simulations of the air velocity within the channel revealed shear stress values ranging from 0.13 to 0.39 Pa,aligning with the desired in vivo shear stress observed in the bronchi regions(0.1–0.4 Pa).Biomechanical movements during resting breathing were mimicked by incorporating a textile mesh positioned away from the cell–cell interface.The epithelial channel demonstrated a capacity for compression and expansion of up to−14.7%and+6.4%,respectively.Microscopic images showed that the epithelial cells formed a uniform monolayer within the lumen of the channel close to the bioprinted endothelial cells.Our novel model offers a valuable tool for future research into respiratory diseases and potential treatments under conditions closely mimicking those in the lung.
基金supported in part by the National Natural Science Foundation of China(No.51890882)the National Natural Science Foundation of China(No.52305075)+1 种基金the China Postdoctoral Science Foundation(No.2023M733065)the Aeronautical Science Foundation of China(No.20220028076003)。
文摘The electro-hydrostatic actuator(EHA)pump is required to operate in a wide range of pressures and speeds to meet the variable output power demands.However,the reliable operation range of EHA pumps is restricted,and the cylinder block tilting is considered a serious factor.This paper presents an analytical approach for evaluating the critical operation range of EHA pumps based on a criterion for cylinder tilting states.It explicitly reveals the fundamental principle of the cylinder block tilting limiting the operation range.The criterion is verified with the measured tilting angle and leakage flow.Results show that the calculated critical conditions accurately identify the inflection point of performance changes.Beyond the critical operation range,the severe cylinder block tilting leads to a sharp increase in leakage and may even result in a sudden failure.Furthermore,the impacts of the center spring force,the piston-slipper assembly mass,and the position of the spline reaction on the critical operation range are investigated.
