Chronic pain and disability following acute orthopedic trauma are not only physical concerns but also deeply intertwined with psychological well-being.The recent retrospective cohort study by Yang et al,published,prov...Chronic pain and disability following acute orthopedic trauma are not only physical concerns but also deeply intertwined with psychological well-being.The recent retrospective cohort study by Yang et al,published,provides compelling evidence of significant associations between depression,anxiety,and postoperative recovery.These findings align with an expanding body of literature that confirms the need for orthopedic rehabilitation to adopt a biopsychosocial perspective.This letter contextualizes Yang et al’s study within current evidence,highlighting the roles of sleep disturbance,catastrophizing,stress,neurobiological mechanisms,and coping strategies in shaping recovery.It further emphasizes the importance of integrating nursing-led and multidisciplinary interventions to address both physical and psychological domains,ultimately promoting holistic recovery.展开更多
AIM:To investigate the effects of zingerone(ZO)on the retina in diabetic rats.METHODS:A total of 70 rats were randomly selected and divided into seven groups[diabetic group(Dm+;n=10),diabetic+metformin group(Dm+Met;n=...AIM:To investigate the effects of zingerone(ZO)on the retina in diabetic rats.METHODS:A total of 70 rats were randomly selected and divided into seven groups[diabetic group(Dm+;n=10),diabetic+metformin group(Dm+Met;n=10),diabetic+ZO25 group(Dm+ZO25;n=10),diabetic+ZO50 group(Dm+ZO50;n=10),diabetic+metformin group+ZO 50 Group(Dm+Met+ZO50;n=10)].Diabetes was induced by streptozotocin(STZ),and metformin and two different doses of ZO were administered via gavage.Retinal tissues were evaluated by histopathological and immunohistochemical analyses.RESULTS:In diabetic rats,severe retinal inflammation,tissue necrosis,and increased tumor necrosis factor-α(TNF-α)expression were observed.ZO administration reduced these effects in a dose-dependent manner.Protective effects of metformin alone were limited,and no synergistic benefit was observed in ZO+Met groups.Administration of 50 mg/kg ZO to non-diabetic rats caused no retinal toxicity.Additionally,elevated 8-OHdG and c-Jun N-terminal kinase(JNK)expressions in diabetic retinopathy models were significantly reduced by ZO treatment.CONCLUSION:ZO can markedly reduce the pathological effects of the retina in a diabetic rat model.展开更多
Wireless Multimedia Sensor Networks(WMSN)are designed to transmit audio and video streams,still images,and scalar data.Multimedia transmission over wireless sensor networks has many applications,such as video surveill...Wireless Multimedia Sensor Networks(WMSN)are designed to transmit audio and video streams,still images,and scalar data.Multimedia transmission over wireless sensor networks has many applications,such as video surveillance,object tracking,telemedicine,theft control systems,and traffic monitoring.Researchers face many challenges,such as higher data rates,lower energy consumption,reliability,signal detection and estimation,uncertainty in network topology,quality of service(QoS),and security-and privacy-related issues to accomplish various applications of WMSN.This paper presents multiple input multiple output(MIMO)along with compressive sensing(CS)properties to improve system performance in terms of energy consumption and QoS in deep fade environments.The CS theory model has been proposed to reduce energy consumption by taking fewer measurements of the original signal or information and reconstructing it with acceptable image quality at the receiver side.The transmission and processing energy can be reduced by transmitting fewer measurements from the sensor side itself.The MIMO model and CS algorithm have been simulated,and results show that CS performs well on images.展开更多
Objective:To investigate the protective effects of naringin on doxorubicin(DOX)-induced liver injury.Methods:A total of 50 male rats were allocated into five groups:the control group,the DOX group,the DOX groups treat...Objective:To investigate the protective effects of naringin on doxorubicin(DOX)-induced liver injury.Methods:A total of 50 male rats were allocated into five groups:the control group,the DOX group,the DOX groups treated with 50 mg/kg and 100 mg/kg of naringin by gastric lavage for 10 days,as well as the group treated with 100 mg/kg of naringin alone.Liver and serum samples were collected for biochemical,histopathological,and molecular analyses,including liver enzyme activity,oxidative stress markers,inflammation,apoptosis-related proteins,and DNA damage indicators.Results:Naringin attenuated DOX-induced elevation in liver enzyme activity and inflammation markers while enhancing antioxidant activities.Naringin also activated the Nrf2-HO-1 signaling pathway,with the most pronounced effect in the high-dose naringin group.In addition,naringin modulated apoptotic signaling by downregulating the expression of PI3K-AKT and BAX,and upregulating Bcl-2,as well as reduced the level of 8-OHdG.Histopathological evaluation showed that DOX-induced structural liver alterations,such as cellular degeneration and necrosis,were notably attenuated by naringin treatment.Conclusions:Naringin treatment exerts protective effects against DOX-induced liver injury through its antioxidative,anti-inflammatory,and anti-apoptotic effects.展开更多
BACKGROUND Hereditary factors are more prevalent in early-onset colorectal cancers(EOCRC)etiology.Lynch syndrome(LS)is the most common hereditary colorectal cancer(CRC)syndrome that results from mutations in DNA misma...BACKGROUND Hereditary factors are more prevalent in early-onset colorectal cancers(EOCRC)etiology.Lynch syndrome(LS)is the most common hereditary colorectal cancer(CRC)syndrome that results from mutations in DNA mismatch repair(MMR)genes.This phenomenon is defined as microsatellite instability(MSI).Immunohistochemistry(IHC)is a widely used,practical,and cost-effective method for the screening of MSI.However,using IHC alone may be insufficient to identify patients with MSI and LS.AIM To determine the clinicopathological features in EOCRC,IHC performance,and the frequency of genetic testing for EOCRC patients.METHODS A retrospective review was conducted on patients with CRC aged≤50 years who underwent surgery at our center between January 2014 and July 2021.MMR proteins were screened using IHC.Of the 131 patients included,IHC was performed on 130.Patients were classified as MSI or microsatellite-stable(MSS),and their features were compared.Additionally,data from patients who received genetic counseling were analyzed.RESULTS Thirty patients with MSI were designated as group 1,whereas 100 with MSS were defined as group 2.The mean age in group 1 was the lowest(median age:42 vs 46,P<0.05).Group 1 exhibited a higher frequency of tumors in the right colon and a lower frequency in the rectum.Lymph node involvement and distant metastases were less common in group 1,and in group 2,tumors were generally diagnosed at a more advanced stage.Genetic testing was performed in 53 patients(40%),with a definitive LS diagnosis established in 13/17 patients(76.4%)in group 1 and 1/36(2.7%)patients in group 2,resulting in a total of 14 patients(26.4%)with confirmed LS.CONCLUSION MSI tumors show a better prognosis.IHC is very effective for screening MSI,but may not be sufficient alone.Low genetic counseling rates highlight the need for hospital-based surveillance programs.展开更多
OBJECTIVE:To examine the effect of electroacupuncture(EA)application on postoperative pain levels and the amount of analgesic use in patients who underwent periodontal flap surgery.METHODS:In this prospective,randomiz...OBJECTIVE:To examine the effect of electroacupuncture(EA)application on postoperative pain levels and the amount of analgesic use in patients who underwent periodontal flap surgery.METHODS:In this prospective,randomized and controlled study,patients planned for periodontal surgery were divided into two groups[EA group(n=22):patients who received electroacupuncture and control group(n=22):patients who did not receive electroacupuncture].Electroacupuncture was applied bilaterally to the Hegu(LI4),Daying(ST5),and Jiache(ST5)points of the patients in the EA group immediately before and after the flap surgery for 30 min at a frequency of 50 Hz to each point at a current that the patient could tolerate.The patients in the control group underwent flap surgery without applying electroacupuncture.Patients were asked to record their pain levels on the visual analog scale and the number of analgesic tablets they took during the 7 postoperative days on the given form.RESULTS:The total mean score of pain felt in the EA group(16.60±2.78)was found to be significantly lower than that in the control group(31.37±2.78)(P=0.001).No significant difference was found between the groups regarding the amount of analgesics taken(4.77±4.72,5.82±3.11)(P=0.111).CONCLUSIONS:Our study shows that electroacupuncture application is beneficial in reducing pain after periodontal flap surgery.Overall,more research is needed to fully understand the effects of electroacupuncture on postoperative pain.展开更多
Plants are continuously exposed to abiotic and biotic stresses that threaten their growth,reproduction,and survival.Adaptation to these stresses requires complex regulatory networks that coordinate physiological,molec...Plants are continuously exposed to abiotic and biotic stresses that threaten their growth,reproduction,and survival.Adaptation to these stresses requires complex regulatory networks that coordinate physiological,molecular,and ecological responses.However,such adaptation often incurs significant costs,including reduced growth,yield penalties,and altered ecological interactions.This review systematically synthesizes recent advances published between 2018 and 2025,following PRISMA criteria,on plant responses to abiotic and biotic stressors,with an emphasis on the trade-offs between adaptation and productivity.It also highlights major discrepancies in the literature and discusses strategies for enhancing plant stress tolerance in agriculture.By integrating findings from genomics,transcriptomics,proteomics,and metabolomics,the review categorizes both mechanistic insights and ecological consequences.The findings underscore the need for multi-stress,systems-level,field-based research that connects molecular processes to ecological and agricultural outcomes.Accordingly,critical gaps are identified—particularly the scarcity of multi-stress and field-based studies—and future directions that integrate omics approaches,systems biology,and eco-physiological frameworks are proposed.Understanding the costs of adaptation is essential not only for breeding resilient,high-yielding crops but also for ensuring their successful incorporation into sustainable agricultural practices under changing climate conditions.展开更多
Wheat is a crucial crop for global food security,and effective in vitro plant regeneration techniques are considered a precondition for genetic engineering in wheat breeding programs.A practical approach for in vitro ...Wheat is a crucial crop for global food security,and effective in vitro plant regeneration techniques are considered a precondition for genetic engineering in wheat breeding programs.A practical approach for in vitro regeneration of the Kirik bread wheat cultivar via somatic embryogenesis was investigated using endospermsupported mature embryos.Callus cultures were initiated from mature embryos supported by endosperm,cultured on phytagel-based Murashige and Skoog(MS)basal mediumcontaining dicamba(12mg/L)and indole-3-acetic acid(IAA)(0.5 mg/L)under dark conditions.This research was designed to examine the impact of putrescine(Put)(0.0 and 1.0 mM)on inducing embryonic callus and the effects of thidiazuron(TDZ)(0.0,0.1,0.2,0.3,0.4,and 0.5 mg/L)on wheat regeneration.Adding 1.0mM putrescine to MS mediumsignificantly increased(p<0.01)embryogenic callus formation,resulting in a complete(100%)induction rate.Moreover,the highest number of regenerated plants per explant(5.8)was obtained through the synergistic interaction between 1.0 mM putrescine and 0.5 mg/L TDZ.To assess the genetic homogeneity of regenerated plants,10 different inter-simple sequence repeat(ISSR)primers were utilized,revealing a high level of genetic stability.The results of all the applications of a particular plant tissue culture technique showed a level of somaclonal variation within acceptable limits,indicating that the genetic diversity of the plant populations was protectedwithout compromising the desired traits.These improvements offer a promising tool forwheat biotechnology,especially for genetic transformation.展开更多
Narrative nursing(NN)is emerging as a critical approach in modern healthcare,addressing the complex interplay between psychological well-being and physical recovery.This manuscript discusses a study on NN and its role...Narrative nursing(NN)is emerging as a critical approach in modern healthcare,addressing the complex interplay between psychological well-being and physical recovery.This manuscript discusses a study on NN and its role in alleviating psychological distress in patients with acute pancreatitis,published in the World Journal of Psychiatry.Their research demonstrates that NN,through structured storytelling,significantly reduces anxiety and depression,thereby enhancing patient satisfaction and fostering emotional resilience.This therapeutic approach extends beyond symptom management,offering a comprehensive strategy that supports the mental and emotional recovery of patients facing severe health challenges.NN provides a unique framework for engaging patients in their care journey,promoting a sense of agency,and strengthening the patient-provider relationship.In this manuscript,we explore the broader implications of NN by synthesizing findings from various studies,showing that NN is effective not only in acute settings but also in oncology,chronic illness management,and palliative care.The evidence indicates that integrating NN into standard clinical practice could enhance healthcare outcomes by addressing the holistic needs of patients,supporting psychological resilience,and fostering a compassionate healthcare environment.展开更多
AIM:To investigate the optimal anti-vascular endothelial growth factor(VEGF)treatment time in patients with diabetic macular edema(DME)scheduled for cataract surgery.METHODS:The study was designed to include 4 groups....AIM:To investigate the optimal anti-vascular endothelial growth factor(VEGF)treatment time in patients with diabetic macular edema(DME)scheduled for cataract surgery.METHODS:The study was designed to include 4 groups.Twenty-six eyes of 26 patients with diabetes but no retinopathy(DR;group 1),17 eyes of 17 patients with DR but no DME(group 2),and 19 eyes of 19 patients with DME who received anti-VEGF therapy concurrently with cataract surgery(group 3),and 21 eyes of 21 patients who received anti-VEGF therapy for DME 1wk before cataract surgery(group 4).The patients’best corrected visual acuity,intraocular pressure,central and mean macular thickness(CMT and MMT)values were noted on the day of surgery,postoperative day 1,week 1,and month 1.RESULTS:There was a significant increase of CMT after cataract surgery in groups 1,2,and 3(P<0.001,P=0.044,and P=0.034,respectively)but not in group 4(P=0.948).The change in MMT was the same as CMT(P=0.009,P=0.006,P=0.011,and P=0.172,respectively).There was a higher increase in CMT and MMT in group 2 compared to group 1 at the 1st month after surgery(P=0.002 and P=0.001,respectively).CONCLUSION:In eyes with DME undergoing cataract surgery,preoperative anti-VEGF treatment may be more effective than simultaneous intravitreal anti-VEGF with surgery.展开更多
BACKGROUND Distribution of the colonic diverticula differs in different populations,and rightsided colon diverticulitis(RCD)and left-sided colon diverticulitis(LCD)manifest distinct clinical features.Complicated diver...BACKGROUND Distribution of the colonic diverticula differs in different populations,and rightsided colon diverticulitis(RCD)and left-sided colon diverticulitis(LCD)manifest distinct clinical features.Complicated diverticulitis(CD)mostly requires hospitalization and can be treated within a spectrum from observation to surgery.Treatment choice is formed depending on the patient’s general condition,the presence of diffuse peritonitis,the localization of diverticulitis,Hinchey stage,and responsiveness to the prior treatment.Clinical disparities regarding right and LCD also led to the differences in the incidences of both emergency surgery and future elective surgery.AIM To evaluate the clinical features of CD,display the differences according to colonic localizations,and present treatment approaches.METHODS This was a retrospective study from a single centre analysing data from a prospective database.The 253 patients with history of hospitalization for CD were included and divided into two groups:RCD and LCD.To compare the differences between the two groups,the Student’s t-test was used when the parametric test prerequisites were fulfilled,and the Mann-Whitney U test was used when such requirements were not fulfilled.RESULTS The 208(82.2%)patients were found to have LCD,and 45(17.8%)had RCD.The majority of the patients had Hinchey 1A diverticulitis(49.8%).Male gender was significantly more common in patients who underwent surgery for LCD.While persistent abdominal pain was the main prior finding in the conservative treatment of both localizations,surgery was most performed due to abscess in RCD and perforation in LCD.The presence of an accompanying malignancy during colonoscopy was significantly more common in LCD cases who underwent surgery.Hartmann’s procedure was the most performed technique in emergency settings(56.3%),while laparoscopic colectomy with anastomosis was in elective settings(53.9%).In addition,surgery was found to prolong the mean length of hospital stay in LCD patients.CONCLUSION Although diverticulitis is a benign condition,the need for an individualized and evidence-based approach makes management challenging.Localization of the disease has an important role in determining the appropriate treatment.展开更多
This paper presents a template-based control method for achieving diverse trotting motions in quadrupedal systems,with a focus on smooth transitions between walking trot,regular trot,and flying(running)trot.First,we e...This paper presents a template-based control method for achieving diverse trotting motions in quadrupedal systems,with a focus on smooth transitions between walking trot,regular trot,and flying(running)trot.First,we extend the Clock Torque Actuated Spring-Loaded Inverted Pendulum(CT-SLIP)template to three dimensions,creating a comprehensive control framework.A template-based control strategy is then developed to compute joint torques for stable locomotion,along with a detailed approach for transitioning between gaits.To enable the flight phase in the running trot,a projectile motion model is incorporated into the template.For improved turning,we implement a yaw control method that rotates the swing foot plane to enhance stability,enabling higher turning rates while maintaining steady forward motion and balance.To further enhance locomotion stability and performance,a Whole-Body Controller(WBC)is integrated.The proposed method is implemented and rigorously evaluated in the MuJoCo simulator,with experiments testing gait transitions and disturbance rejection.Additionally,comparative studies assess the impacts of both swing foot plane rotation and the WBC on overall system performance.Furthermore,the approach is validated through real hardware experiments on Unitree GO1 quadrupedal robot,successfully demonstrating smooth gait transitions,stable locomotion,and practical applicability in real-world scenarios.展开更多
AIM:To examine the subclinical alterations in the retina and choroid between patients with 2019 coronavirus disease(COVID-19)-related lung involvement and the healthy control group.METHODS:In this prospective case-con...AIM:To examine the subclinical alterations in the retina and choroid between patients with 2019 coronavirus disease(COVID-19)-related lung involvement and the healthy control group.METHODS:In this prospective case-control study,85 cases with lung involvement due to COVID-19 and 50 healthy cases were included.Best-corrected visual acuity,intraocular pressure measurement,and anterior and posterior segment examination were performed on both eyes for each individual.Choroidal and retinal changes were examined and recorded by optical coherence tomography angiography.RESULTS:All choroidal thickness measurements of the COVID-19 group showed no statistically significant difference when compared to healthy individuals.When vascular density and perfusion density values were compared,there was a decrease in the average of these values in the COVID-19 group,although it was not statistically significant(P=0.088,P=0.065 respectively).When the fovea avascular zone(FAZ)area values were compared,the average was 0.57±0.38 in the COVID-19 group,while it was 0.54±0.24 in the control group.CONCLUSION:Although our data are not statistically significant,the decrease in vascularity and perfusion and the accompanying FAZ expansion are detected in the acute period(1st month).These changes may anatomically alter the retina in the long term and affect functional vision.Future ischemia-related alterations in the retina caused by a prior COVID-19 infection may arise in situations without comorbidities and may require concern in the patient’s systemic assessment.展开更多
BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is an invasive endoscopic procedure used mainly to treat hepato-pancreato-biliary(HPB)diseases.The need for ERCP has increased with the rising number of H...BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is an invasive endoscopic procedure used mainly to treat hepato-pancreato-biliary(HPB)diseases.The need for ERCP has increased with the rising number of HPB diseases over the past decade.Thus,due to increased demand,ERCP is performed at more centers.Currently,it is performed by general surgeons,gastroenterology and invasive radiology specialists in the United States and Europe as recommended by the British Society of Gastroenterology(BSG).AIM To present the results of ERCP procedures from fourteen surgical centers in Türkiye.METHODS Fourteen surgical centers performing ERCP were included in the present study.The age,gender,ERCP indication,success status,post-ERCP complications,ERCP reports and the files of 66993 patients who underwent ERCP were collected from the participating centers.The results are discussed according to the targets declared by the BSG,which are volume load per annum,proportion of successful cannulation(>85%),bile duct clearance rate(>75%),stenting rate for strictures(>80%)and complications(<6%).RESULTS A total of 66993 ERCP procedures were performed in the centers included in the study up to August 2024.29250(43.6%)of the procedures were performed urgently,especially for suppurative cholangitis,biliary tract injuries,etc.The remaining 37743(56.4%)cases were performed electively.50.2%of the patients were female and 49.8%were male.The average ages were 56.5 years for women and 55.9 years for men.General anesthesia was used in 84.1%of the patients while sedation was used in 15.9%.The indications were bile duct stone(78.7%),pancreatic tumor(3.9%),papillary tumor(3.3%),cholangiocarcinoma(2.6%),Oddi sphincter dysfunction(2.4%),bile leakage after cholecystectomy(2%),bile leakage after hydatid cyst surgery(1.9%),biliary stricture(1.7%),and other diseases(3.1%).Hyperamylasemia and post-ERCP pancreatitis were the most common complications as observed in 8.1%of the patients.They were usually self-limited and responded to supportive measures.The frequency of the other complications was also consistent with the literature.CONCLUSION There is a huge shortage of ERCP endoscopists worldwide due to insufficient ERCP training and centers especially in developing and underdeveloped countries.As patients requiring ERCP usually present to surgical practitioners,the incorporation of surgeons into this training program is an effective and reliable solution.The BSG recommends the incorporation of surgeons and radiologists in addition to gastroenterology specialists.This study is the first to present the results of ERCP procedures from fourteen surgical centers throughout Türkiye.The results suggest that the surgical centers included were able to achieve the targets set by the BSG.This study demonstrated that the surgical ERCP units in the present work have reached satisfactory results and provided a reliable and successful ERCP service.There are currently no issues regarding the validity and appropriateness of the surgeons performing ERCP.Therefore,ERCP training should be encouraged in surgeons and more surgical ERCP centers should be provided.展开更多
Background and objectives:The ongoing mpox outbreaks have garnered significant attention due to their public health implications,particularly the potential mental health impacts.Despite the growing concern,there has b...Background and objectives:The ongoing mpox outbreaks have garnered significant attention due to their public health implications,particularly the potential mental health impacts.Despite the growing concern,there has been limited exploration of the intersection between mpox and mental health within the research literature.This study aims to conduct a comprehensive bibliometric analysis to examine global research trends,regional distribution,and thematic focus areas related to mpox's psychological and psychiatric implications.Methods:We conducted a bibliometric analysis using Scopus and the Web of Science database.The analysis was carried out using the R-bibliometrics package and involved identifying literature on mpox and mental health,focusing on global research trends,regional distribution,and thematic areas of study.The analysis included 416 documents obtained from 295 sources from January 1,2014 to August 27,2024.Results:Our analysis revealed a growing but unevenly distributed literature on mpox and mental health.Most studies concentrated on the relationship between mpox and conditions such as depression and anxiety,while other psychiatric outcomes remain underexplored.The geographic distribution of research was also uneven,with regions like Europe and the Americas receiving more focus than others.Conclusions:The study highlights the need for more targeted research on the mental health sequelae of mpox,particularly for vulnerable populations and regions that are currently underrepresented in the literature.Future research should include longitudinal studies to assess the long-term effects of mpox on mental health and the development of robust methodologies to establish causality.Integrating mental health considerations into public health responses to mpox outbreaks is crucial,with significant implications for research,policy,and clinical practice.展开更多
AIM:To determine the relationship of pulmonary abnormalities and bowel disease activity in inflammatory bowel disease(IBD).METHODS:Thirty ulcerative colitis(UC)and nine Crohn's disease patients,and 20 control subj...AIM:To determine the relationship of pulmonary abnormalities and bowel disease activity in inflammatory bowel disease(IBD).METHODS:Thirty ulcerative colitis(UC)and nine Crohn's disease patients,and 20 control subjects were enrolled in this prospective study.Detailed clinical information was obtained.Extent and activity of the bowel disease were established endoscopically.Each patient underwent pulmonary function tests and high-resolution computed tomography(HRCT).Blood samples for measurement of C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),angiotensin converting enzyme and total IgE were delivered by the patients.RESULTS:Ten(25.6%)patients had respiratory symptoms.A pulmonary function abnormality was present in 22 of 39 patients.Among all patients,the most prevalent abnormalities in lung functions were a decrease in forced expiratory volume in 1 s(FEV1),FEV1/forced vital capacity(FVC),forced expiratory flow(FEF)25%-75%,transfer coefficient for carbon monoxide(DLCO),DLCO/alveolar volume.Increased respiratory symptoms score was associated with high endoscopic activity index in UC patients.Endoscopic and clinical activities in UC patients were correlated with FEV1,FEV1/FVC,and FEF 25%-75%.Smoking status,duration of disease and medication were not correlated with pulmonary physiological test results,HRCT abnormalities,clinical/endoscopic disease activity,CRP,ESR or total IgE level or body mass index.CONCLUSION:It is important that respiratory manifestations are recognized and treated early in IBD.Otherwise,they can lead to destructive and irreversible changes in the airway wall.展开更多
AIM： To present our clinical experience with gallbladder perforation cases.METHODS： Records of 332 patients who received medical and/or surgical treatment with the diagnosis of acute cholecystitis in our clinic betw...AIM： To present our clinical experience with gallbladder perforation cases.METHODS： Records of 332 patients who received medical and/or surgical treatment with the diagnosis of acute cholecystitis in our clinic between 1997 and 2006 were reviewed retrospectively. Sixteen （4.8%） of those patients had gallbladder perforation. The parameters including age, gender, time from the onset of symptoms to the time of surgery, diagnostic procedures, surgical treatment, morbidity, and mortality were evaluated.RESULTS： Seven patients had type I gallbladder perforation, 7 type I gallbladder perforation, and 2 type m gallbladder perforation according to Niemeier＇ s classification. The patients underwent surgery after administration of intravenous electrolyte solutions, and were treated with analgesics and antibiotics within the first 36 h （mean 9 h） after admission. Two patients died of sepsis and multiple organ failure in the early postoperative period. Subhepatic abscess, pelvic abscess, pneumonia, pancreatitis, and acute renal failure were found in 6 patients.CONCLUSION： Early diagnosis and emergency surgical treatment of gallbladder perforation are of crucial importance. Upper abdominal computerized tomography for acute cholecystitis patients may contribute to the preoperative diagnosis of gallbladder perforation.展开更多
AIM： To investigate the relationship between myeloperoxidase polymorphisms as a host-related factor and atrophy caused by H pylori. METHODS： Our study enrolled 77 patients. Biopsy materials obtained during gastroint...AIM： To investigate the relationship between myeloperoxidase polymorphisms as a host-related factor and atrophy caused by H pylori. METHODS： Our study enrolled 77 patients. Biopsy materials obtained during gastrointestinal endoscopies were evaluated for the presence of H pylori. Polymerase chain reaction-restriction fragment length polymorphism assay was used to characterize myeloperoxidase genothpes. RESULTS： Forty four patients （57.1%） were lip （＋） and 33 （42.9%） were Hp （-）. Sixty six （85.7%） had GG genotype, 10 （12.9%） had GA genotype and 1 （1.29%） had AA genotype. The change in atrophy in relation to neutrophil infiltration was significant in Hp （＋） patients （P = 0.0001）. The change in atrophy in relation to neutrophil infiltration in patients with GG genotype was significant （P = 0.002）. However, the change in atrophy in relation to neutrophil infiltration was not significiant in patients with Hp （＋） GG genotype （r = 0.066, P = 0.63）. CONCLUSION： Myeloperoxidase genotype is critical for development of atrophy in relation to the severity of inflammation. However, it is interesting to note that, H pylori does not show any additive effect on development of atrophy.展开更多
Fruit yield, yield components, fruit mineral content, total phenolic content, antioxidant activity and irrigation water use efifciency （IWUE） of summer squash responses to different irrigation quantities were evalua...Fruit yield, yield components, fruit mineral content, total phenolic content, antioxidant activity and irrigation water use efifciency （IWUE） of summer squash responses to different irrigation quantities were evaluated with a ifeld study. Irrigations were done when the total evaporated water from a Class A pan was about 30 mm. Different irrigation quantities were adjusted using three different plant-pan coefifcients （Kcp, 100% （Kcp1）, 85% （Kcp2） and 70% （Kcp3））. Results indicated that lower irrigation quantities provided statistically lower yield and yield components. The highest seasonal fruit yield （80.0 t ha-1） was determined in the Kcp1 treatment, which applied the highest volume of irrigation water （452.9 mm）. The highest early fruit yield, average fruit weight and fruit diameter, length and number per plant were also determined in the Kcp1 treatment, with values of 7.25 t ha-1, 264.1 g, 5.49 cm, 19.95 cm and 10.92, respectively. Although the IWUE value was the highest in the Kcp1 treatment （176.6 kg ha-1 mm-1）, it was statistically similar to the value for Kcp3 treatment （157.1 kg ha-1 mm-1）. Total phenolic content and antioxidant activity of fruits was higher in the Kcp1 （44.27 μg gallic acid equivalents （GAE） mg-1 fresh sample） and in the Kcp2 （84.75%） treatments, respectively. Major （Na, N, P, K, Ca, Mg and S） and trace （Fe, Cu, Mn, Zn and B） mineral contents of squash fruits were the highest in the Kcp2 treatment, with the exception of P, Ca and Cu. Mineral contents and total phenolic content were signiifcantly affected by irrigation quantities, but antioxidant activity was not affected. It can be concluded that the Kcp1 treatment was the most suitable for achieving higher yield and IWUE. However, the Kcp2 treatment will be the most suitable due to the high fruit quality and relatively high yield in water shortage conditions.展开更多
In order to meet the demands of high temperature components in automobile, the microstructure and mechanical properties of several new die-casting AZ91-rare earth (RE) magnesium alloys were studied. The alloys were ch...In order to meet the demands of high temperature components in automobile, the microstructure and mechanical properties of several new die-casting AZ91-rare earth (RE) magnesium alloys were studied. The alloys were characterized by optical microscopy (OM), scan electron microscopy (SEM), energy dispersive X-ray spectrometry (EDX), tensile and creep tests. The results show that Ce addition has little effect on the mechanical properties of AZ91 alloy at high temperature, while Y and Nd addition play important role in the improvement of creep resistance. New alloys containing Y or Nd with excellent high temperature performance are selected to produce cylinder head cover of high power diesel engine of Red Flag car and oil pan of Besturn car. The new magnesium alloys with RE addition for die-casting have potential to produce power-train parts, and can greatly decrease weight.展开更多
文摘Chronic pain and disability following acute orthopedic trauma are not only physical concerns but also deeply intertwined with psychological well-being.The recent retrospective cohort study by Yang et al,published,provides compelling evidence of significant associations between depression,anxiety,and postoperative recovery.These findings align with an expanding body of literature that confirms the need for orthopedic rehabilitation to adopt a biopsychosocial perspective.This letter contextualizes Yang et al’s study within current evidence,highlighting the roles of sleep disturbance,catastrophizing,stress,neurobiological mechanisms,and coping strategies in shaping recovery.It further emphasizes the importance of integrating nursing-led and multidisciplinary interventions to address both physical and psychological domains,ultimately promoting holistic recovery.
文摘AIM:To investigate the effects of zingerone(ZO)on the retina in diabetic rats.METHODS:A total of 70 rats were randomly selected and divided into seven groups[diabetic group(Dm+;n=10),diabetic+metformin group(Dm+Met;n=10),diabetic+ZO25 group(Dm+ZO25;n=10),diabetic+ZO50 group(Dm+ZO50;n=10),diabetic+metformin group+ZO 50 Group(Dm+Met+ZO50;n=10)].Diabetes was induced by streptozotocin(STZ),and metformin and two different doses of ZO were administered via gavage.Retinal tissues were evaluated by histopathological and immunohistochemical analyses.RESULTS:In diabetic rats,severe retinal inflammation,tissue necrosis,and increased tumor necrosis factor-α(TNF-α)expression were observed.ZO administration reduced these effects in a dose-dependent manner.Protective effects of metformin alone were limited,and no synergistic benefit was observed in ZO+Met groups.Administration of 50 mg/kg ZO to non-diabetic rats caused no retinal toxicity.Additionally,elevated 8-OHdG and c-Jun N-terminal kinase(JNK)expressions in diabetic retinopathy models were significantly reduced by ZO treatment.CONCLUSION:ZO can markedly reduce the pathological effects of the retina in a diabetic rat model.
文摘Wireless Multimedia Sensor Networks(WMSN)are designed to transmit audio and video streams,still images,and scalar data.Multimedia transmission over wireless sensor networks has many applications,such as video surveillance,object tracking,telemedicine,theft control systems,and traffic monitoring.Researchers face many challenges,such as higher data rates,lower energy consumption,reliability,signal detection and estimation,uncertainty in network topology,quality of service(QoS),and security-and privacy-related issues to accomplish various applications of WMSN.This paper presents multiple input multiple output(MIMO)along with compressive sensing(CS)properties to improve system performance in terms of energy consumption and QoS in deep fade environments.The CS theory model has been proposed to reduce energy consumption by taking fewer measurements of the original signal or information and reconstructing it with acceptable image quality at the receiver side.The transmission and processing energy can be reduced by transmitting fewer measurements from the sensor side itself.The MIMO model and CS algorithm have been simulated,and results show that CS performs well on images.
基金supported by the Atatürk University Scientific Research Projects Coordinator(Project No:2020/8737)。
文摘Objective:To investigate the protective effects of naringin on doxorubicin(DOX)-induced liver injury.Methods:A total of 50 male rats were allocated into five groups:the control group,the DOX group,the DOX groups treated with 50 mg/kg and 100 mg/kg of naringin by gastric lavage for 10 days,as well as the group treated with 100 mg/kg of naringin alone.Liver and serum samples were collected for biochemical,histopathological,and molecular analyses,including liver enzyme activity,oxidative stress markers,inflammation,apoptosis-related proteins,and DNA damage indicators.Results:Naringin attenuated DOX-induced elevation in liver enzyme activity and inflammation markers while enhancing antioxidant activities.Naringin also activated the Nrf2-HO-1 signaling pathway,with the most pronounced effect in the high-dose naringin group.In addition,naringin modulated apoptotic signaling by downregulating the expression of PI3K-AKT and BAX,and upregulating Bcl-2,as well as reduced the level of 8-OHdG.Histopathological evaluation showed that DOX-induced structural liver alterations,such as cellular degeneration and necrosis,were notably attenuated by naringin treatment.Conclusions:Naringin treatment exerts protective effects against DOX-induced liver injury through its antioxidative,anti-inflammatory,and anti-apoptotic effects.
文摘BACKGROUND Hereditary factors are more prevalent in early-onset colorectal cancers(EOCRC)etiology.Lynch syndrome(LS)is the most common hereditary colorectal cancer(CRC)syndrome that results from mutations in DNA mismatch repair(MMR)genes.This phenomenon is defined as microsatellite instability(MSI).Immunohistochemistry(IHC)is a widely used,practical,and cost-effective method for the screening of MSI.However,using IHC alone may be insufficient to identify patients with MSI and LS.AIM To determine the clinicopathological features in EOCRC,IHC performance,and the frequency of genetic testing for EOCRC patients.METHODS A retrospective review was conducted on patients with CRC aged≤50 years who underwent surgery at our center between January 2014 and July 2021.MMR proteins were screened using IHC.Of the 131 patients included,IHC was performed on 130.Patients were classified as MSI or microsatellite-stable(MSS),and their features were compared.Additionally,data from patients who received genetic counseling were analyzed.RESULTS Thirty patients with MSI were designated as group 1,whereas 100 with MSS were defined as group 2.The mean age in group 1 was the lowest(median age:42 vs 46,P<0.05).Group 1 exhibited a higher frequency of tumors in the right colon and a lower frequency in the rectum.Lymph node involvement and distant metastases were less common in group 1,and in group 2,tumors were generally diagnosed at a more advanced stage.Genetic testing was performed in 53 patients(40%),with a definitive LS diagnosis established in 13/17 patients(76.4%)in group 1 and 1/36(2.7%)patients in group 2,resulting in a total of 14 patients(26.4%)with confirmed LS.CONCLUSION MSI tumors show a better prognosis.IHC is very effective for screening MSI,but may not be sufficient alone.Low genetic counseling rates highlight the need for hospital-based surveillance programs.
文摘OBJECTIVE:To examine the effect of electroacupuncture(EA)application on postoperative pain levels and the amount of analgesic use in patients who underwent periodontal flap surgery.METHODS:In this prospective,randomized and controlled study,patients planned for periodontal surgery were divided into two groups[EA group(n=22):patients who received electroacupuncture and control group(n=22):patients who did not receive electroacupuncture].Electroacupuncture was applied bilaterally to the Hegu(LI4),Daying(ST5),and Jiache(ST5)points of the patients in the EA group immediately before and after the flap surgery for 30 min at a frequency of 50 Hz to each point at a current that the patient could tolerate.The patients in the control group underwent flap surgery without applying electroacupuncture.Patients were asked to record their pain levels on the visual analog scale and the number of analgesic tablets they took during the 7 postoperative days on the given form.RESULTS:The total mean score of pain felt in the EA group(16.60±2.78)was found to be significantly lower than that in the control group(31.37±2.78)(P=0.001).No significant difference was found between the groups regarding the amount of analgesics taken(4.77±4.72,5.82±3.11)(P=0.111).CONCLUSIONS:Our study shows that electroacupuncture application is beneficial in reducing pain after periodontal flap surgery.Overall,more research is needed to fully understand the effects of electroacupuncture on postoperative pain.
文摘Plants are continuously exposed to abiotic and biotic stresses that threaten their growth,reproduction,and survival.Adaptation to these stresses requires complex regulatory networks that coordinate physiological,molecular,and ecological responses.However,such adaptation often incurs significant costs,including reduced growth,yield penalties,and altered ecological interactions.This review systematically synthesizes recent advances published between 2018 and 2025,following PRISMA criteria,on plant responses to abiotic and biotic stressors,with an emphasis on the trade-offs between adaptation and productivity.It also highlights major discrepancies in the literature and discusses strategies for enhancing plant stress tolerance in agriculture.By integrating findings from genomics,transcriptomics,proteomics,and metabolomics,the review categorizes both mechanistic insights and ecological consequences.The findings underscore the need for multi-stress,systems-level,field-based research that connects molecular processes to ecological and agricultural outcomes.Accordingly,critical gaps are identified—particularly the scarcity of multi-stress and field-based studies—and future directions that integrate omics approaches,systems biology,and eco-physiological frameworks are proposed.Understanding the costs of adaptation is essential not only for breeding resilient,high-yielding crops but also for ensuring their successful incorporation into sustainable agricultural practices under changing climate conditions.
文摘Wheat is a crucial crop for global food security,and effective in vitro plant regeneration techniques are considered a precondition for genetic engineering in wheat breeding programs.A practical approach for in vitro regeneration of the Kirik bread wheat cultivar via somatic embryogenesis was investigated using endospermsupported mature embryos.Callus cultures were initiated from mature embryos supported by endosperm,cultured on phytagel-based Murashige and Skoog(MS)basal mediumcontaining dicamba(12mg/L)and indole-3-acetic acid(IAA)(0.5 mg/L)under dark conditions.This research was designed to examine the impact of putrescine(Put)(0.0 and 1.0 mM)on inducing embryonic callus and the effects of thidiazuron(TDZ)(0.0,0.1,0.2,0.3,0.4,and 0.5 mg/L)on wheat regeneration.Adding 1.0mM putrescine to MS mediumsignificantly increased(p<0.01)embryogenic callus formation,resulting in a complete(100%)induction rate.Moreover,the highest number of regenerated plants per explant(5.8)was obtained through the synergistic interaction between 1.0 mM putrescine and 0.5 mg/L TDZ.To assess the genetic homogeneity of regenerated plants,10 different inter-simple sequence repeat(ISSR)primers were utilized,revealing a high level of genetic stability.The results of all the applications of a particular plant tissue culture technique showed a level of somaclonal variation within acceptable limits,indicating that the genetic diversity of the plant populations was protectedwithout compromising the desired traits.These improvements offer a promising tool forwheat biotechnology,especially for genetic transformation.
文摘Narrative nursing(NN)is emerging as a critical approach in modern healthcare,addressing the complex interplay between psychological well-being and physical recovery.This manuscript discusses a study on NN and its role in alleviating psychological distress in patients with acute pancreatitis,published in the World Journal of Psychiatry.Their research demonstrates that NN,through structured storytelling,significantly reduces anxiety and depression,thereby enhancing patient satisfaction and fostering emotional resilience.This therapeutic approach extends beyond symptom management,offering a comprehensive strategy that supports the mental and emotional recovery of patients facing severe health challenges.NN provides a unique framework for engaging patients in their care journey,promoting a sense of agency,and strengthening the patient-provider relationship.In this manuscript,we explore the broader implications of NN by synthesizing findings from various studies,showing that NN is effective not only in acute settings but also in oncology,chronic illness management,and palliative care.The evidence indicates that integrating NN into standard clinical practice could enhance healthcare outcomes by addressing the holistic needs of patients,supporting psychological resilience,and fostering a compassionate healthcare environment.
文摘AIM:To investigate the optimal anti-vascular endothelial growth factor(VEGF)treatment time in patients with diabetic macular edema(DME)scheduled for cataract surgery.METHODS:The study was designed to include 4 groups.Twenty-six eyes of 26 patients with diabetes but no retinopathy(DR;group 1),17 eyes of 17 patients with DR but no DME(group 2),and 19 eyes of 19 patients with DME who received anti-VEGF therapy concurrently with cataract surgery(group 3),and 21 eyes of 21 patients who received anti-VEGF therapy for DME 1wk before cataract surgery(group 4).The patients’best corrected visual acuity,intraocular pressure,central and mean macular thickness(CMT and MMT)values were noted on the day of surgery,postoperative day 1,week 1,and month 1.RESULTS:There was a significant increase of CMT after cataract surgery in groups 1,2,and 3(P<0.001,P=0.044,and P=0.034,respectively)but not in group 4(P=0.948).The change in MMT was the same as CMT(P=0.009,P=0.006,P=0.011,and P=0.172,respectively).There was a higher increase in CMT and MMT in group 2 compared to group 1 at the 1st month after surgery(P=0.002 and P=0.001,respectively).CONCLUSION:In eyes with DME undergoing cataract surgery,preoperative anti-VEGF treatment may be more effective than simultaneous intravitreal anti-VEGF with surgery.
文摘BACKGROUND Distribution of the colonic diverticula differs in different populations,and rightsided colon diverticulitis(RCD)and left-sided colon diverticulitis(LCD)manifest distinct clinical features.Complicated diverticulitis(CD)mostly requires hospitalization and can be treated within a spectrum from observation to surgery.Treatment choice is formed depending on the patient’s general condition,the presence of diffuse peritonitis,the localization of diverticulitis,Hinchey stage,and responsiveness to the prior treatment.Clinical disparities regarding right and LCD also led to the differences in the incidences of both emergency surgery and future elective surgery.AIM To evaluate the clinical features of CD,display the differences according to colonic localizations,and present treatment approaches.METHODS This was a retrospective study from a single centre analysing data from a prospective database.The 253 patients with history of hospitalization for CD were included and divided into two groups:RCD and LCD.To compare the differences between the two groups,the Student’s t-test was used when the parametric test prerequisites were fulfilled,and the Mann-Whitney U test was used when such requirements were not fulfilled.RESULTS The 208(82.2%)patients were found to have LCD,and 45(17.8%)had RCD.The majority of the patients had Hinchey 1A diverticulitis(49.8%).Male gender was significantly more common in patients who underwent surgery for LCD.While persistent abdominal pain was the main prior finding in the conservative treatment of both localizations,surgery was most performed due to abscess in RCD and perforation in LCD.The presence of an accompanying malignancy during colonoscopy was significantly more common in LCD cases who underwent surgery.Hartmann’s procedure was the most performed technique in emergency settings(56.3%),while laparoscopic colectomy with anastomosis was in elective settings(53.9%).In addition,surgery was found to prolong the mean length of hospital stay in LCD patients.CONCLUSION Although diverticulitis is a benign condition,the need for an individualized and evidence-based approach makes management challenging.Localization of the disease has an important role in determining the appropriate treatment.
基金supported by The Scientific and Technological Research Council of Türkiye(TUBITAK)1515 Frontier R&D Laboratories Support Program for Turk Telekom neXt Generation Technologies Lab(XGeNTT)under Project No.5249902supported by the Scientific Research Projects Coordination Unit of Middle East Technical University(METU)under Project No.ADEP-301-2025-11613.
文摘This paper presents a template-based control method for achieving diverse trotting motions in quadrupedal systems,with a focus on smooth transitions between walking trot,regular trot,and flying(running)trot.First,we extend the Clock Torque Actuated Spring-Loaded Inverted Pendulum(CT-SLIP)template to three dimensions,creating a comprehensive control framework.A template-based control strategy is then developed to compute joint torques for stable locomotion,along with a detailed approach for transitioning between gaits.To enable the flight phase in the running trot,a projectile motion model is incorporated into the template.For improved turning,we implement a yaw control method that rotates the swing foot plane to enhance stability,enabling higher turning rates while maintaining steady forward motion and balance.To further enhance locomotion stability and performance,a Whole-Body Controller(WBC)is integrated.The proposed method is implemented and rigorously evaluated in the MuJoCo simulator,with experiments testing gait transitions and disturbance rejection.Additionally,comparative studies assess the impacts of both swing foot plane rotation and the WBC on overall system performance.Furthermore,the approach is validated through real hardware experiments on Unitree GO1 quadrupedal robot,successfully demonstrating smooth gait transitions,stable locomotion,and practical applicability in real-world scenarios.
文摘AIM:To examine the subclinical alterations in the retina and choroid between patients with 2019 coronavirus disease(COVID-19)-related lung involvement and the healthy control group.METHODS:In this prospective case-control study,85 cases with lung involvement due to COVID-19 and 50 healthy cases were included.Best-corrected visual acuity,intraocular pressure measurement,and anterior and posterior segment examination were performed on both eyes for each individual.Choroidal and retinal changes were examined and recorded by optical coherence tomography angiography.RESULTS:All choroidal thickness measurements of the COVID-19 group showed no statistically significant difference when compared to healthy individuals.When vascular density and perfusion density values were compared,there was a decrease in the average of these values in the COVID-19 group,although it was not statistically significant(P=0.088,P=0.065 respectively).When the fovea avascular zone(FAZ)area values were compared,the average was 0.57±0.38 in the COVID-19 group,while it was 0.54±0.24 in the control group.CONCLUSION:Although our data are not statistically significant,the decrease in vascularity and perfusion and the accompanying FAZ expansion are detected in the acute period(1st month).These changes may anatomically alter the retina in the long term and affect functional vision.Future ischemia-related alterations in the retina caused by a prior COVID-19 infection may arise in situations without comorbidities and may require concern in the patient’s systemic assessment.
文摘BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is an invasive endoscopic procedure used mainly to treat hepato-pancreato-biliary(HPB)diseases.The need for ERCP has increased with the rising number of HPB diseases over the past decade.Thus,due to increased demand,ERCP is performed at more centers.Currently,it is performed by general surgeons,gastroenterology and invasive radiology specialists in the United States and Europe as recommended by the British Society of Gastroenterology(BSG).AIM To present the results of ERCP procedures from fourteen surgical centers in Türkiye.METHODS Fourteen surgical centers performing ERCP were included in the present study.The age,gender,ERCP indication,success status,post-ERCP complications,ERCP reports and the files of 66993 patients who underwent ERCP were collected from the participating centers.The results are discussed according to the targets declared by the BSG,which are volume load per annum,proportion of successful cannulation(>85%),bile duct clearance rate(>75%),stenting rate for strictures(>80%)and complications(<6%).RESULTS A total of 66993 ERCP procedures were performed in the centers included in the study up to August 2024.29250(43.6%)of the procedures were performed urgently,especially for suppurative cholangitis,biliary tract injuries,etc.The remaining 37743(56.4%)cases were performed electively.50.2%of the patients were female and 49.8%were male.The average ages were 56.5 years for women and 55.9 years for men.General anesthesia was used in 84.1%of the patients while sedation was used in 15.9%.The indications were bile duct stone(78.7%),pancreatic tumor(3.9%),papillary tumor(3.3%),cholangiocarcinoma(2.6%),Oddi sphincter dysfunction(2.4%),bile leakage after cholecystectomy(2%),bile leakage after hydatid cyst surgery(1.9%),biliary stricture(1.7%),and other diseases(3.1%).Hyperamylasemia and post-ERCP pancreatitis were the most common complications as observed in 8.1%of the patients.They were usually self-limited and responded to supportive measures.The frequency of the other complications was also consistent with the literature.CONCLUSION There is a huge shortage of ERCP endoscopists worldwide due to insufficient ERCP training and centers especially in developing and underdeveloped countries.As patients requiring ERCP usually present to surgical practitioners,the incorporation of surgeons into this training program is an effective and reliable solution.The BSG recommends the incorporation of surgeons and radiologists in addition to gastroenterology specialists.This study is the first to present the results of ERCP procedures from fourteen surgical centers throughout Türkiye.The results suggest that the surgical centers included were able to achieve the targets set by the BSG.This study demonstrated that the surgical ERCP units in the present work have reached satisfactory results and provided a reliable and successful ERCP service.There are currently no issues regarding the validity and appropriateness of the surgeons performing ERCP.Therefore,ERCP training should be encouraged in surgeons and more surgical ERCP centers should be provided.
文摘Background and objectives:The ongoing mpox outbreaks have garnered significant attention due to their public health implications,particularly the potential mental health impacts.Despite the growing concern,there has been limited exploration of the intersection between mpox and mental health within the research literature.This study aims to conduct a comprehensive bibliometric analysis to examine global research trends,regional distribution,and thematic focus areas related to mpox's psychological and psychiatric implications.Methods:We conducted a bibliometric analysis using Scopus and the Web of Science database.The analysis was carried out using the R-bibliometrics package and involved identifying literature on mpox and mental health,focusing on global research trends,regional distribution,and thematic areas of study.The analysis included 416 documents obtained from 295 sources from January 1,2014 to August 27,2024.Results:Our analysis revealed a growing but unevenly distributed literature on mpox and mental health.Most studies concentrated on the relationship between mpox and conditions such as depression and anxiety,while other psychiatric outcomes remain underexplored.The geographic distribution of research was also uneven,with regions like Europe and the Americas receiving more focus than others.Conclusions:The study highlights the need for more targeted research on the mental health sequelae of mpox,particularly for vulnerable populations and regions that are currently underrepresented in the literature.Future research should include longitudinal studies to assess the long-term effects of mpox on mental health and the development of robust methodologies to establish causality.Integrating mental health considerations into public health responses to mpox outbreaks is crucial,with significant implications for research,policy,and clinical practice.
文摘AIM:To determine the relationship of pulmonary abnormalities and bowel disease activity in inflammatory bowel disease(IBD).METHODS:Thirty ulcerative colitis(UC)and nine Crohn's disease patients,and 20 control subjects were enrolled in this prospective study.Detailed clinical information was obtained.Extent and activity of the bowel disease were established endoscopically.Each patient underwent pulmonary function tests and high-resolution computed tomography(HRCT).Blood samples for measurement of C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),angiotensin converting enzyme and total IgE were delivered by the patients.RESULTS:Ten(25.6%)patients had respiratory symptoms.A pulmonary function abnormality was present in 22 of 39 patients.Among all patients,the most prevalent abnormalities in lung functions were a decrease in forced expiratory volume in 1 s(FEV1),FEV1/forced vital capacity(FVC),forced expiratory flow(FEF)25%-75%,transfer coefficient for carbon monoxide(DLCO),DLCO/alveolar volume.Increased respiratory symptoms score was associated with high endoscopic activity index in UC patients.Endoscopic and clinical activities in UC patients were correlated with FEV1,FEV1/FVC,and FEF 25%-75%.Smoking status,duration of disease and medication were not correlated with pulmonary physiological test results,HRCT abnormalities,clinical/endoscopic disease activity,CRP,ESR or total IgE level or body mass index.CONCLUSION:It is important that respiratory manifestations are recognized and treated early in IBD.Otherwise,they can lead to destructive and irreversible changes in the airway wall.
文摘AIM： To present our clinical experience with gallbladder perforation cases.METHODS： Records of 332 patients who received medical and/or surgical treatment with the diagnosis of acute cholecystitis in our clinic between 1997 and 2006 were reviewed retrospectively. Sixteen （4.8%） of those patients had gallbladder perforation. The parameters including age, gender, time from the onset of symptoms to the time of surgery, diagnostic procedures, surgical treatment, morbidity, and mortality were evaluated.RESULTS： Seven patients had type I gallbladder perforation, 7 type I gallbladder perforation, and 2 type m gallbladder perforation according to Niemeier＇ s classification. The patients underwent surgery after administration of intravenous electrolyte solutions, and were treated with analgesics and antibiotics within the first 36 h （mean 9 h） after admission. Two patients died of sepsis and multiple organ failure in the early postoperative period. Subhepatic abscess, pelvic abscess, pneumonia, pancreatitis, and acute renal failure were found in 6 patients.CONCLUSION： Early diagnosis and emergency surgical treatment of gallbladder perforation are of crucial importance. Upper abdominal computerized tomography for acute cholecystitis patients may contribute to the preoperative diagnosis of gallbladder perforation.
文摘AIM： To investigate the relationship between myeloperoxidase polymorphisms as a host-related factor and atrophy caused by H pylori. METHODS： Our study enrolled 77 patients. Biopsy materials obtained during gastrointestinal endoscopies were evaluated for the presence of H pylori. Polymerase chain reaction-restriction fragment length polymorphism assay was used to characterize myeloperoxidase genothpes. RESULTS： Forty four patients （57.1%） were lip （＋） and 33 （42.9%） were Hp （-）. Sixty six （85.7%） had GG genotype, 10 （12.9%） had GA genotype and 1 （1.29%） had AA genotype. The change in atrophy in relation to neutrophil infiltration was significant in Hp （＋） patients （P = 0.0001）. The change in atrophy in relation to neutrophil infiltration in patients with GG genotype was significant （P = 0.002）. However, the change in atrophy in relation to neutrophil infiltration was not significiant in patients with Hp （＋） GG genotype （r = 0.066, P = 0.63）. CONCLUSION： Myeloperoxidase genotype is critical for development of atrophy in relation to the severity of inflammation. However, it is interesting to note that, H pylori does not show any additive effect on development of atrophy.
文摘Fruit yield, yield components, fruit mineral content, total phenolic content, antioxidant activity and irrigation water use efifciency （IWUE） of summer squash responses to different irrigation quantities were evaluated with a ifeld study. Irrigations were done when the total evaporated water from a Class A pan was about 30 mm. Different irrigation quantities were adjusted using three different plant-pan coefifcients （Kcp, 100% （Kcp1）, 85% （Kcp2） and 70% （Kcp3））. Results indicated that lower irrigation quantities provided statistically lower yield and yield components. The highest seasonal fruit yield （80.0 t ha-1） was determined in the Kcp1 treatment, which applied the highest volume of irrigation water （452.9 mm）. The highest early fruit yield, average fruit weight and fruit diameter, length and number per plant were also determined in the Kcp1 treatment, with values of 7.25 t ha-1, 264.1 g, 5.49 cm, 19.95 cm and 10.92, respectively. Although the IWUE value was the highest in the Kcp1 treatment （176.6 kg ha-1 mm-1）, it was statistically similar to the value for Kcp3 treatment （157.1 kg ha-1 mm-1）. Total phenolic content and antioxidant activity of fruits was higher in the Kcp1 （44.27 μg gallic acid equivalents （GAE） mg-1 fresh sample） and in the Kcp2 （84.75%） treatments, respectively. Major （Na, N, P, K, Ca, Mg and S） and trace （Fe, Cu, Mn, Zn and B） mineral contents of squash fruits were the highest in the Kcp2 treatment, with the exception of P, Ca and Cu. Mineral contents and total phenolic content were signiifcantly affected by irrigation quantities, but antioxidant activity was not affected. It can be concluded that the Kcp1 treatment was the most suitable for achieving higher yield and IWUE. However, the Kcp2 treatment will be the most suitable due to the high fruit quality and relatively high yield in water shortage conditions.
基金Project(2006AA03Z520) supported by the National High-tech Research and Development Program of China
文摘In order to meet the demands of high temperature components in automobile, the microstructure and mechanical properties of several new die-casting AZ91-rare earth (RE) magnesium alloys were studied. The alloys were characterized by optical microscopy (OM), scan electron microscopy (SEM), energy dispersive X-ray spectrometry (EDX), tensile and creep tests. The results show that Ce addition has little effect on the mechanical properties of AZ91 alloy at high temperature, while Y and Nd addition play important role in the improvement of creep resistance. New alloys containing Y or Nd with excellent high temperature performance are selected to produce cylinder head cover of high power diesel engine of Red Flag car and oil pan of Besturn car. The new magnesium alloys with RE addition for die-casting have potential to produce power-train parts, and can greatly decrease weight.
