目的分析前置审核系统及六西格玛管理模式对门诊用药医嘱合格率的干预效果,以期提高药学服务质量,保障患者用药安全、合理、有效。方法收集北京医院2020年4月至2024年3月门诊处方合格率信息,利用中断时间序列分析(interrupted time seri...目的分析前置审核系统及六西格玛管理模式对门诊用药医嘱合格率的干预效果,以期提高药学服务质量,保障患者用药安全、合理、有效。方法收集北京医院2020年4月至2024年3月门诊处方合格率信息,利用中断时间序列分析(interrupted time series analysis,ITSA)的多阶段模型对前置审核系统全科室开展前、开展后,以及在前置审核基础上实施六西格玛管理法3个阶段门诊处方合格率的变化情况进行分析。结果ITSA结果显示,在全科室开展前置审核之前,我院门诊处方合格率基本稳定,约为86.56%。开展前置审核之后,当月处方合格率较前提高了9.81%,且处方合格率以0.17%的增长率呈逐月上升的趋势。2021年11月,在处方前置审核的基础上结合定义-测量-分析-改进-控制(DMAIC)管理法实施后,当月处方合格率提升至98.07%,达到目标值,处方合格率以每月0.05%的趋势持续提升。结论开展处方前置审核,实施六西格玛管理有助于形成事前审核、事中干预、事后点评、结果公示、及时沟通反馈的闭环管理模式,显著提升了门诊合理用药水平,更好地规范了医生处方行为,促进药师与医师的沟通协作,保障患者用药安全。展开更多
The inhibitory allelopathic activity of </span><i><span style="font-family:Verdana;">Pueraria montana </span></i></span><span style="font-family:Verdana;">...The inhibitory allelopathic activity of </span><i><span style="font-family:Verdana;">Pueraria montana </span></i></span><span style="font-family:Verdana;">(Kudzu), and activities of two putative allelochemical isoflavones, puerarin and daidzein, were evaluated using the protoplast co-culture method with digital image analysis using lettuce as a recipient (DIA-PP</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">method). Cotyledon protoplasts of Kudzu were isolated using Cellulase R10 and Driselase 20 in 0.6 M mannitol solution. Optimal hormonal condition and density for growth of Kudzu protoplasts were surveyed. Medium for co-culture of Kudzu or isoflavones with lettuce protoplasts was 50 μl liquid MS basal medium containing 1 μM 2,4-dichlorophenoxyacetic acid, 0.1 μM benzyladenine, 3% sucrose, and 0.4 M or 0.6 M mannitol. Protoplast division of lettuce was strongly inhibited by Kudzu at a low density (10</span><sup><span style="font-family:Verdana;">4</span></sup><span style="font-family:Verdana;">/ml). Slightly less inhibition by Kudzu on cell wall formation and yellow pigment accumulation stages of lettuce growth was also observed. Puerarin did not inhibit the growth of lettuce protoplasts at three growth stages but slightly stimulated growth at high concentrations. By contrast, daidzein, aglycon of puerarin, inhibited growth at three stages of lettuce protoplast growth and strongly inhibited cell division at 100 μM. Daidzein might be one cause of the strong inhibitory allelopathic activity of Kudzu. Grade of inhibitory activities w</span></span><span style="font-family:Verdana;">as</span><span style="font-family:Verdana;"> compared with th</span><span style="font-family:Verdana;">at</span><span style="font-family:Verdana;"> of other allelopathic plants including an invader plant and their allelochemicals studied using the DIA-PP method.展开更多
We compared resistance to decay, mold fungi, termites and insect larvae of particleboards incorporated with the raw boron minerals ulexite and colemanite to that of particleboards impregnated with the commercial boron...We compared resistance to decay, mold fungi, termites and insect larvae of particleboards incorporated with the raw boron minerals ulexite and colemanite to that of particleboards impregnated with the commercial boron preservative zinc borate, or boric acid plus a borax mixture. We also quantified water absorption, thickness swell and boron release of particleboards. Ulexite had the best decay resistance, and colemanite had the best termite resistance. However, ulexite and colemanite were not as effective as zinc borate or the boric acid/borax mixture in preventing mold growth. In general, the boric acid/borax mixture combination was more effective against Anobium larvae than the other treatments. Less boron was released by specimens containing zinc borate and colemanite than by those containing ulexite or the boric acid/borax mixture. In general, water absorption and thickness swell were similar among the different treatments, but both were slightly higher in the ulexite-incorporated specimens. Further mechanical tests will be needed to evaluate the particle- board properties and thereby the compatibility of these boron minerals with various manufacturing processes.展开更多
We evaluated fungal decay and mold resistance,leaching, and water absorption of nano-compounds and Paraloid B72-（PB72） in treated wood specimens to develop new methods of consolidation by combining nanoparticles and...We evaluated fungal decay and mold resistance,leaching, and water absorption of nano-compounds and Paraloid B72-（PB72） in treated wood specimens to develop new methods of consolidation by combining nanoparticles and consolidants. Scots pine wood specimens were treated with dispersions of nano-Cu O, nano-Zn O,nano-B2O3, nano-Ti O2, and nano-Ce O2. PB72 treatments of nano-particle-treated wood specimens were then carried out by either vacuum or immersion for 24 h. Previously,decayed wood specimens were also consolidated with the nano-compounds and PB72. PB72 treatments reduced element release from treated wood specimens. Nearly all nano-compounds ？ PB72 treatments increased the biological performance of treated wood specimens against decay fungi tested. PB72-only treated wood specimens had the highest weight losses in decay tests. No improvements were obtained in mold resistance tests when the nanocompounds and PB72 were combined. In nano-compoundonly treatments, unleached specimens showed slightly lower water absorption values compared to untreated control specimens. Incorporation of PB72 into nano-compound-treated wood specimens resulted in considerably lower water absorption and volumetric swell. In previously decayed specimens treated with the nano-compounds and PB72 solution, water absorption after 2-h immersion declined compared to control specimens.展开更多
文摘目的分析前置审核系统及六西格玛管理模式对门诊用药医嘱合格率的干预效果,以期提高药学服务质量,保障患者用药安全、合理、有效。方法收集北京医院2020年4月至2024年3月门诊处方合格率信息,利用中断时间序列分析(interrupted time series analysis,ITSA)的多阶段模型对前置审核系统全科室开展前、开展后,以及在前置审核基础上实施六西格玛管理法3个阶段门诊处方合格率的变化情况进行分析。结果ITSA结果显示,在全科室开展前置审核之前,我院门诊处方合格率基本稳定,约为86.56%。开展前置审核之后,当月处方合格率较前提高了9.81%,且处方合格率以0.17%的增长率呈逐月上升的趋势。2021年11月,在处方前置审核的基础上结合定义-测量-分析-改进-控制(DMAIC)管理法实施后,当月处方合格率提升至98.07%,达到目标值,处方合格率以每月0.05%的趋势持续提升。结论开展处方前置审核,实施六西格玛管理有助于形成事前审核、事中干预、事后点评、结果公示、及时沟通反馈的闭环管理模式,显著提升了门诊合理用药水平,更好地规范了医生处方行为,促进药师与医师的沟通协作,保障患者用药安全。
文摘The inhibitory allelopathic activity of </span><i><span style="font-family:Verdana;">Pueraria montana </span></i></span><span style="font-family:Verdana;">(Kudzu), and activities of two putative allelochemical isoflavones, puerarin and daidzein, were evaluated using the protoplast co-culture method with digital image analysis using lettuce as a recipient (DIA-PP</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">method). Cotyledon protoplasts of Kudzu were isolated using Cellulase R10 and Driselase 20 in 0.6 M mannitol solution. Optimal hormonal condition and density for growth of Kudzu protoplasts were surveyed. Medium for co-culture of Kudzu or isoflavones with lettuce protoplasts was 50 μl liquid MS basal medium containing 1 μM 2,4-dichlorophenoxyacetic acid, 0.1 μM benzyladenine, 3% sucrose, and 0.4 M or 0.6 M mannitol. Protoplast division of lettuce was strongly inhibited by Kudzu at a low density (10</span><sup><span style="font-family:Verdana;">4</span></sup><span style="font-family:Verdana;">/ml). Slightly less inhibition by Kudzu on cell wall formation and yellow pigment accumulation stages of lettuce growth was also observed. Puerarin did not inhibit the growth of lettuce protoplasts at three growth stages but slightly stimulated growth at high concentrations. By contrast, daidzein, aglycon of puerarin, inhibited growth at three stages of lettuce protoplast growth and strongly inhibited cell division at 100 μM. Daidzein might be one cause of the strong inhibitory allelopathic activity of Kudzu. Grade of inhibitory activities w</span></span><span style="font-family:Verdana;">as</span><span style="font-family:Verdana;"> compared with th</span><span style="font-family:Verdana;">at</span><span style="font-family:Verdana;"> of other allelopathic plants including an invader plant and their allelochemicals studied using the DIA-PP method.
基金financially supported by the Coordination Unit for Scientific Research of Istanbul University,Turkey(Project Nos:32421 and BEK 20218)
文摘We compared resistance to decay, mold fungi, termites and insect larvae of particleboards incorporated with the raw boron minerals ulexite and colemanite to that of particleboards impregnated with the commercial boron preservative zinc borate, or boric acid plus a borax mixture. We also quantified water absorption, thickness swell and boron release of particleboards. Ulexite had the best decay resistance, and colemanite had the best termite resistance. However, ulexite and colemanite were not as effective as zinc borate or the boric acid/borax mixture in preventing mold growth. In general, the boric acid/borax mixture combination was more effective against Anobium larvae than the other treatments. Less boron was released by specimens containing zinc borate and colemanite than by those containing ulexite or the boric acid/borax mixture. In general, water absorption and thickness swell were similar among the different treatments, but both were slightly higher in the ulexite-incorporated specimens. Further mechanical tests will be needed to evaluate the particle- board properties and thereby the compatibility of these boron minerals with various manufacturing processes.
基金financially supported by the Coordination Unit for Scientific Research of Istanbul University,Turkey(Project No:45503)
文摘We evaluated fungal decay and mold resistance,leaching, and water absorption of nano-compounds and Paraloid B72-（PB72） in treated wood specimens to develop new methods of consolidation by combining nanoparticles and consolidants. Scots pine wood specimens were treated with dispersions of nano-Cu O, nano-Zn O,nano-B2O3, nano-Ti O2, and nano-Ce O2. PB72 treatments of nano-particle-treated wood specimens were then carried out by either vacuum or immersion for 24 h. Previously,decayed wood specimens were also consolidated with the nano-compounds and PB72. PB72 treatments reduced element release from treated wood specimens. Nearly all nano-compounds ？ PB72 treatments increased the biological performance of treated wood specimens against decay fungi tested. PB72-only treated wood specimens had the highest weight losses in decay tests. No improvements were obtained in mold resistance tests when the nanocompounds and PB72 were combined. In nano-compoundonly treatments, unleached specimens showed slightly lower water absorption values compared to untreated control specimens. Incorporation of PB72 into nano-compound-treated wood specimens resulted in considerably lower water absorption and volumetric swell. In previously decayed specimens treated with the nano-compounds and PB72 solution, water absorption after 2-h immersion declined compared to control specimens.
