BACKGROUND Orthopaedic surgical education has traditionally depended on the apprenticeship model of“see one,do one,teach one”.However,reduced operative exposure,stricter work-hour regulations,medicolegal constraints...BACKGROUND Orthopaedic surgical education has traditionally depended on the apprenticeship model of“see one,do one,teach one”.However,reduced operative exposure,stricter work-hour regulations,medicolegal constraints,and patient safety concerns have constrained its practicality.Simulation-based training has become a reliable,safe,and cost-efficient alternative.Dry lab techniques,especially virtual and augmented reality,make up 78%of current dry lab research,whereas wet labs still set the standard for anatomical realism.AIM To evaluate the effectiveness,limitations,and future directions of wet and dry lab simulation in orthopaedic training.METHODS A scoping review was carried out across four databases-PubMed,Cochrane Library,Web of Science,and EBSCOhost-up to 2025.Medical Subject Headings included:"Orthopaedic Education","Wet Lab","Dry Lab","Simulation Training","Virtual Reality",and"Surgical Procedure".Eligible studies focused on orthopaedic or spinal surgical education,employed wet or dry lab techniques,and assessed training effectiveness.Exclusion criteria consisted of non-English publications,abstracts only,non-orthopaedic research,and studies unrelated to simulation.Two reviewers independently screened titles,abstracts,and full texts,resolving discrepancies with a third reviewer.RESULTS From 1851 records,101 studies met inclusion:78 on dry labs,7 on wet labs,4 on both.Virtual reality(VR)simulations were most common,with AI increasingly used for feedback and assessment.Cadaveric training remains the gold standard for accuracy and tactile feedback,while dry labs-especially VR-offer scalability,lower cost(40%-60%savings in five studies),and accessibility for novices.Senior residents prefer wet labs for complex tasks;juniors favour dry labs for basics.Challenges include limited transferability data,lack of standard outcome metrics,and ethical concerns about cadaver use and AI assessment.CONCLUSION Wet and dry labs each have unique strengths in orthopaedic training.A hybrid approach combining both,supported by standardised assessments and outcome studies,is most effective.Future efforts should aim for uniform reporting,integrating new technologies,and policy support for hybrid curricula to enhance skills and patient care.展开更多
Developing novel anti-infective drugs is essential to combat antimicrobial resistance,address emerging pathogens,and safeguard global health against evolving infectious threats.A recent publication in the esteemed jou...Developing novel anti-infective drugs is essential to combat antimicrobial resistance,address emerging pathogens,and safeguard global health against evolving infectious threats.A recent publication in the esteemed journal Nature by Qisen Deng et al.reported on the comprehensive evaluation of the therapeutic efficacy of mandimycin against multidrug-resistant(MDR)fungal pathogens.The polyene macrolide antifungal antibiotic,mandimycin,was discovered using a phylogeny-guided natural-product discovery platform.Authors utilized various in vivo mouse models such as systemic and soft-tissue infections to assess the antifungal activity of mandimycin.The efficacy was measured by quantifying the fungal burden in major organs and assessing survival rates.In systemic infections,mandimycin demonstrated significant dose-dependent antifungal efficacy,as compared to amphotericin B,particularly in cases where the latter was ineffective against MDR C.auris.Furthermore,mandimycin showed a favorable safety profile,with low toxicity and no observed side effects at effective doses.The study's findings contribute valuable insights into the potential of mandimycin as a novel antifungal agent,offering hope for improved treatment options against challenging fungal infections.The results pave the way for further research and clinical applications in the fight against antifungal resistance.展开更多
Background Relative energy deficiency in sport(REDs)results from exposure to problematic low energy availability.It is a serious condition affecting the health and athletic performance of up to 80%of elite female athl...Background Relative energy deficiency in sport(REDs)results from exposure to problematic low energy availability.It is a serious condition affecting the health and athletic performance of up to 80%of elite female athletes.REDs is established to have negative short-term effects on reproductive function,but the long-term impact of this condition is unknown.Therefore,we examined the impact of secondary amenorrhea with or without a concurrent diagnosis of REDs on perinatal health outcomes.Methods Postpartum individuals(≥18 years of age)completed an online questionnaire that covered demographics,reproductive history(including a diagnosis of REDs or secondary amenorrhea),and maternal/fetal health outcomes.Logistic regression was used to determine the relationship between previously diagnosed REDs or secondary amenorrhea with perinatal health outcomes.Results A total of 1025 previously pregnant participants completed the survey(33.1±3.4 years,mean±SD).Prior to pregnancy,6.1%had been previously diagnosed with REDs and 20.5%had a history with secondary amenorrhea.Individuals diagnosed with REDs had 3.5-times higher odds of having premature labor(odds ratio,(OR)=3.52,95%confidence interval(95%CI):1.26–9.81)and 2.6-times higher odds of preterm delivery(OR=2.62,95%CI:1.05–6.58)compared to those who had not experienced REDs or secondary amenorrhea.However,in individuals who did not have a history of REDs,secondary amenorrhea did not increase the odds of adverse pregnancy or delivery outcomes.Conclusion A history of REDs,but not secondary amenorrhea,may increase the odds of premature labor and preterm delivery.展开更多
The hilly purple soil area is a major grainproducing region in southwestern China,where noticeable land use change has occurred along with socio-economic development over recent decades.Degradation of ecosystem servic...The hilly purple soil area is a major grainproducing region in southwestern China,where noticeable land use change has occurred along with socio-economic development over recent decades.Degradation of ecosystem services(ESs)is therefore widespread.Understanding the interactions among ESs in the case of anthropogenic disturbance and environmental change is needed for sustainable land management.Here,we analyze the synergies/tradeoffs and bundles between ESs in this region between 1990-2015.By using the InVEST model,Geo-Detector method,and multi-source datasets,we investigated the socio-ecological drivers that dominate the dynamics of ESs.We found that ESs exhibit divergent temporal trends;food production shows a rising trend,habitat quality a declining trend,and water yield a highly variable response.Provisioning services,especially food production,have common and enduring trade-offs with other ESs.Mutual transformation occurred between ES bundles with water related ES bundles experiencing a weakness in synergistic effects.ESs that are predominantly driven by ecological drivers have gradually become controlled by social drivers which suggests the impacts of human activities in ESs are gradually increasing.Thus,integrated management policies such as land consolidation are needed to coordinate management.This study provides strategies based on ES bundles with different functional and management priorities.Also,integrating vertical zoning into land management to ensure sustainable agricultural production in lowland basins.展开更多
Extreme Mei-yu rainfall(MYR)can cause catastrophic impacts to the economic development and societal welfare in China.While significant improvements have been made in climate models,they often struggle to simulate loca...Extreme Mei-yu rainfall(MYR)can cause catastrophic impacts to the economic development and societal welfare in China.While significant improvements have been made in climate models,they often struggle to simulate local-to-regional extreme rainfall(e.g.,MYR).Yet,large-scale climate modes(LSCMs)are relatively well represented in climate models.Since there exists a close relationship between MYR and various LSCMs,it might be possible to develop causality-guided statistical models for MYR prediction based on LSCMs.These statistical models could then be applied to climate model simulations to improve the representation of MYR in climate models.In this pilot study,it is demonstrated that skillful causality-guided statistical models for MYR can be constructed based on known LSCMs.The relevancy of the selected predictors for statistical models are found to be consistent with the literature.The importance of temporal resolution in constructing statistical models for MYR is also shown and is in good agreement with the literature.The results demonstrate the reliability of the causality-guided approach in studying complex circulation systems such as the East Asian summer monsoon(EASM).Some limitations and possible improvements of the current approach are discussed.The application of the causality-guided approach opens up a new possibility to uncover the complex interactions in the EASM in future studies.展开更多
Tianshanbeilu is the largest Bronze Age site in eastern Xinjiang, China. Stretching across the entire second millennium BC, it performed a prominent role in connecting the Hexi corridor, Central China and the steppe. ...Tianshanbeilu is the largest Bronze Age site in eastern Xinjiang, China. Stretching across the entire second millennium BC, it performed a prominent role in connecting the Hexi corridor, Central China and the steppe. A further insight into the metallurgical tradition and the metal supply network is of vital importance to improve our understanding of its multi-connected nature. This paper offers a new set of chemical and isotopic data on the copper-based objects at Tianshanbeilu, including alloying elements, trace elements(impurities) and lead isotopes. Combining the concentrations of arsenic and antimony reveals that arsenic was introduced to copper partially due to the use of specific minerals tethrahedrite-tennantite. Lead isotopes demonstrate that multiple sources of copper were employed at Tianshanbeilu and a majority of them are characterized by common lead, which appears rather different from those of the Central Plains and the Hexi corridor, but highly consistent with local ores. Surprisingly, one object at Tianshanbeilu contains the well-known highly radiogenic lead. This object undoubtedly marks the westernmost boundary of the distribution of the highly radiogenic lead. We also anticipate that more lead isotopic analyses in NW China will further contribute to the study of the highly radiogenic lead in Central China.展开更多
High quality polytene chromosome maps （n=3） of a Himalayan Simuliid Simulium praelargum Datta, 1973 are presented and represent the first cytological description of a taxon found in the feuerborni group, subgenus Ne...High quality polytene chromosome maps （n=3） of a Himalayan Simuliid Simulium praelargum Datta, 1973 are presented and represent the first cytological description of a taxon found in the feuerborni group, subgenus Nevermannia. Polytene chromosomes one （I） and two （II） are metacentric, chromosome three （III） is submetacentric with the length of each chromosome occupying 37.25 %, 31.36 % and 31.34 % of the total complement length, respectively. Typical simuliid diagnostic intergeneric chromosomal markers are found within the polytene complement of this species. The nucleolar organizer （N.O.） is found at the base of the short arm of chromosome one （IS）, the Ring of Balbiani （R.B.）, double bubble （D.B.） and triad occur in the short arm of chromosome two （IIS）, the Parabalbiani Ring （EB.） and grey band （gb） occur in the long arm of chromosome two （IIL） and the Blister （BL） and Capsule （Ca） occur in the short arm of chromosome three （IIIS）.Terminal bands at the end of IIIS are heterochromatinized and present atypically with respect to other simuliid fauna. Populations studied so far are unique among the Simuliidae in that they exhibit chromosome structural monomorphism. These high resolution polytene chromosome maps will form the basis for future cytological characterization and phylogenetic comparisons amongst members of the feuerborni group展开更多
Emerging adulthood(EA)is a critical stage of life to develop and sustain a healthy lifestyle,which is also a time of vulnerability to poor physical and mental health outcomes.In this study,we conducted a path analysis...Emerging adulthood(EA)is a critical stage of life to develop and sustain a healthy lifestyle,which is also a time of vulnerability to poor physical and mental health outcomes.In this study,we conducted a path analysis(N=1326)to examine associations among four dimensions of EA,levels of regular physical activity(PA),self-control,MPA tendency and irrational procrastination.Results found:1)higher levels of PA predicted both MPA tendency(β=−0.08,95%CI:−0.11 to−0.06,p<0.001)and irrational procrastination(β=−0.01,95%CI:−0.17 to−0.008,p<0.01)indirectly via self-control;2)Instability(β=0.13,95%CI:0.08 to 0.18,p<0.01)and Responsibility(β=−0.06,95%CI:−0.10 to−0.08,p=0.03)exerted direct effects on irrational procrastination and Instability also indirectly predicted irrational procrastination via MPA tendency(β=0.03,95%CI:0.02 to 0.05,p<0.01).These findings proved that perceived features of EA are linked to behavioral problems and supported that regular PA plays a crucial role to protect mental health.展开更多
Rice fields are a major source of greenhouse gases,such as nitrous oxide (N_(2)O) and methane (CH_(4)).Organic fertilizers may potentially replace inorganic fertilizers to meet the nitrogen requirement for rice growth...Rice fields are a major source of greenhouse gases,such as nitrous oxide (N_(2)O) and methane (CH_(4)).Organic fertilizers may potentially replace inorganic fertilizers to meet the nitrogen requirement for rice growth;however,the simultaneous effects of organic fertilizers on N_(2)O and CH_(4)emissions and crop yield in paddy fields remain poorly understood and quantified.In this study,experimental plots were established in conventional double-cropping paddy fields in the Pearl River Delta,China,including an unfertilized control and five fertilizer treatments with fresh organic fertilizer (FOF),successively composted organic fertilizer (SOF),chemically composted organic fertilizer (COF),COF supplemented with inorganic fertilizer (COIF),and chemical fertilizers (CFs)(TFOF,TSOF,TCOF,TCOIF,and TCF,respectively).Paddy field soils behaved simultaneously as an N_(2)O sink (cumulative N_(2)O emission:-196 to-381 g N ha^(-1)) and as a CH_(4)source (cumulative CH_(4)emission:719 to 2 178 kg ha^(-1)).Compared to CFs,the effects of organic fertilizers on N_(2)O emission were not significant.In contrast,total annual CH_(4)emission increased by 157%,132%,125%,and 37%in TFOF,TCOF,TSOF,and TCOIF,respectively,compared to TCF.In TCOIF,rice yield was maintained,while CH_(4)emission was not significantly increased from the paddy fields characterized by a prolonged flood period.An important next step is to extend these field-based measurements to larger rice cultivation areas to quantify the regional and national-scale impacts on greenhouse gas emissions and to help determine the optimum practice for fertilizer use.展开更多
AIM To investigate the potential effect of inhibitors of phosphodiesterase-5(PDE-5) for therapy of portal hypertension in liver cirrhosis.METHODS In the rat model of thioacetamide-induced liver fibrosis/cirrhosis the ...AIM To investigate the potential effect of inhibitors of phosphodiesterase-5(PDE-5) for therapy of portal hypertension in liver cirrhosis.METHODS In the rat model of thioacetamide-induced liver fibrosis/cirrhosis the nitric oxide-cyclic guanosine monophosphate(NO-cGMP) pathway was investigated. Expression and localization of PDE-5, the enzyme that converts vasodilating cGMP into inactive 5'-GMP, was in the focus of the study. Hepatic gene expression of key components of the NO-cGMP pathway was determined by qRT-PCR: Endothelial NO synthase(eNOS), inducible NO synthase(iNOS), soluble guanylate cyclase subunits α1 and β1(sGCa1, sGCb1), and PDE-5. Hepatic PDE-5 protein expression and localization were detected by immunohistochemistry. Serum cGMP concentrations were measured using ELISA. Acute effects of the PDE-5 inhibitor Sildenafil(0.1 mg/kg or 1.0 mg/kg) on portal and systemic hemodynamics were investigated using pressure transducers.RESULTS Hepatic gene expression of eNOS(2.2-fold; P = 0.003), sGCa1(1.7-fold; P = 0.003), sGCb1(3.0-fold; P = 0.003), and PDE-5(11-fold; P = 0.003) was increased in cirrhotic livers compared to healthy livers. Overexpression of PDE-5(7.7-fold; P = 0.006) was less pronounced in fibrotic livers. iNOS expression was only detected in fibrotic and cirrhotic livers. In healthy liver, PDE-5 protein was localized primarily in zone 3 hepatocytes and to a lesser extent in perisinusoidal cells. This zonation was disturbed in cirrhosis: PDE-5 protein expression in perisinusoidal cells was induced approximately 8-fold. In addition, PDE-5-expressing cells were also found in fibrous septa. Serum cGMP concentrations were reduced in rats with cirrhotic livers by approximately 40%. Inhibition of PDE-5 by Sildenafil caused a significant increase in serum cGMP concentrations [+ 64% in healthy rats(P = 0.024), + 85% in cirrhotic rats(P = 0.018)]. Concomitantly, the portal venous pressure was reduced by 19% in rats with liver cirrhosis. CONCLUSION Overexpression and abrogated zonation of PDE-5 likely contribute to the pathogenesis of cirrhotic portal hypertension. PDE-5 inhibition may therefore be a reasonable therapeutic approach for portal hypertension.展开更多
Ammonia(NH_(3)) volatilization from rice fields contributes to poor air quality and indicates low nitrogen use efficiency. Although organic fertilizers can meet the nitrogen requirement for rice growth, the simultaneo...Ammonia(NH_(3)) volatilization from rice fields contributes to poor air quality and indicates low nitrogen use efficiency. Although organic fertilizers can meet the nitrogen requirement for rice growth, the simultaneous effects of organic fertilizers on NH_(3) volatilization and rice yield in paddy fields are poorly understood and quantified. To address this gap in our knowledge, experimental field plots were established in a conventional double-cropping paddy field in the Pearl River Delta region, southern China. Five fertilizer treatments were used besides the control with no fertilizer: fresh organic fertilizer, successively composted organic fertilizer, chemically composted organic fertilizer, mixture of chemically composted organic fertilizer with inorganic fertilizer, and chemical fertilizer. Ammonia volatilization was measured using a batch-type airflow enclosure method. No significant differences in grain yield were observed among organic and chemical fertilizer treatments. However, compared with chemical fertilizer, chemically composted organic fertilizer and successively composted organic fertilizer significantly decreased total NH_(3) volatilization by 70% and 68%, respectively. The ammonium-nitrogen concentration in field surface water correlated strongly(P < 0.01) and positively with NH_(3) volatilization across fertilization treatments. Our findings demonstrate that chemically composted organic fertilizer can sustain rice yield while reducing NH_(3) volatilization. An important future step is to promote these field measurements to similar rice cultivation areas to quantify the regional-and national-scale impact on air quality and nitrogen deposition in sensitive areas, and to design and implement better fertilizer management practices.展开更多
This study focused on the encapsulation of vancomycin(VAN) into liposomes coated with a red blood cell membrane with a targeting ligand, daptomycin–polyethylene glycol–1,2-distearoyl-sn-glycero-3-phosphoethanolamine...This study focused on the encapsulation of vancomycin(VAN) into liposomes coated with a red blood cell membrane with a targeting ligand, daptomycin–polyethylene glycol–1,2-distearoyl-sn-glycero-3-phosphoethanolamine, formed by conjugation of DAPT and Nhydroxysuccinimidyl-polyethylene glycol-1,2-distearoyl-sn-glycero-3-phosphoethanolamine.This formulation is capable of providing controlled and targeted drug delivery to the bacterial cytoplasm. We performed MALDI-TOF, NMR and FTIR analyses to confirm the conjugation of the targeting ligand via the formation of amide bonds. Approximately 45% of VAN could be loaded into the aqueous cores, whereas 90% DAPT was detected using UV–vis spectrophotometry. In comparison to free drugs, the formulations controlled the release of drugs for > 72 h. Additionally, as demonstrated using CLSM and flow cytometry, the resulting formulation was capable of evading detection by macrophage cells. In comparison to free drugs, red blood cell membrane–DAPT–VAN liposomes, DAPT liposomes, and VAN liposomes reduced the MIC and significantly increased bacterial permeability, resulting in > 80% bacterial death within 4 h. Cytotoxicity tests were performed in vitro and in vivo on mammalian cells,in addition to hemolytic activity tests in human erythrocytes, wherein drugs loaded into the liposomes and RBCDVL exhibited low toxicity. Thus, the findings of this study provide insight about a dual antibiotic targeting strategy that utilizes liposomes and red blood cell membranes to deliver targeted drugs against MRSA.展开更多
Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of stagin...Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway.展开更多
Labile organic carbon(LOC)plays a pivotal role in soil biogeochemistry and ecological functions.China’s coastal wetlands have been profoundly impacted due to plant invasion and land use change,but the effects on soil...Labile organic carbon(LOC)plays a pivotal role in soil biogeochemistry and ecological functions.China’s coastal wetlands have been profoundly impacted due to plant invasion and land use change,but the effects on soil LOC quantity and composition are unclear.This study analyzed the soil LOC components—namely,dissolved organic carbon(DOC),easily oxidizable carbon(EOC),and microbial biomass carbon(MBC)—across twenty-one coastal wetlands in southeastern China.These wetlands underwent a uniform land cover transition from native mudflats(MFs)to Spartina alterniflora marshes(SAs),and eventually to aquaculture ponds(APs).The results indicated that EOC was the dominant component of soil organic carbon(SOC)(57.5%–61.6%),followed by MBC(3.5%–4.5%)and DOC(<0.5%).The transition from MFs to SAs led to a rise in mean EOC and DOC by 18.6%and 41.4%,respectively.Subsequent conversion of SAs to APs resulted in a reduction in mean EOC and DOC by 5.9%and 20.3%,respectively.MBC did not differ significantly among habitat types.Total nitrogen availability was the main driver of changes in LOC across both land cover change scenarios.The mineralization rate of SOC were more strongly correlated with DOC than EOC and MBC.Microbial turnover of EOC was temperature dependent across the geographical range.These finds highlighted that plant invasion and land use change affected LOC fractions and subsequent SOC stability and carbon emissions in coastal wetlands.展开更多
Over the past decades,both agriculture and power systems have faced serious problems,such as the power supply shortage in agriculture,and difficulties of clean energy consump-tion in the power system.To address and ov...Over the past decades,both agriculture and power systems have faced serious problems,such as the power supply shortage in agriculture,and difficulties of clean energy consump-tion in the power system.To address and overcome these issues,this paper proposes an idea to combine smart agriculture and clean energy consumption,use surplus clean energy to supply agriculture production,and utilize smart agriculture to support power system with clean energy penetration.A comprehensive review has been conducted to first depict the roadmap of coupling a agriculture-clean energy system,analyze their feasibilities and advantages.The recent technologies and bottlenecks are summa-rized and evaluated for the development of a combined system consisting of smart agriculture production and clean energy consumption.Several case studies are introduced to explore the mutual benefits of agriculture-clean energy systems in both the energy and food industries.展开更多
Local energy systems are undergoing significant transformation by integrating more solar photovoltaics(PVs)and battery energy storage systems(BESS)to achieve net-zero targets in the energy sector.To ensure an affordab...Local energy systems are undergoing significant transformation by integrating more solar photovoltaics(PVs)and battery energy storage systems(BESS)to achieve net-zero targets in the energy sector.To ensure an affordable and sustainable decarbonisation process,optimising both system design and operation together is crucial for maximising system profitability and encouraging broader stakeholder participation in the energy transition.However,the complex interdependent influence on the system economic flows,along with the nonlinear characteristics of the system,make the economic optimisation extremely challenging.To address this,we developed a new framework based on advanced artificial intelligence to exploit a wider arbitrage margin under various trading mechanisms,including net metering,day-ahead,and dynamic frequency.We conducted optimisation study on a local energy system operating at University of Warwick using real data from demonstrated BESS and solar PVs,and the effectiveness of the proposed intelligent approach was validated,and the necessity of interdependent optimisation was highlighted.Results showed that,compared to the original campus system(20 MW-level),a carbon reduction rate of up to 61.4%was achieved through net metering trading,while a maximum annual profit increase of 251%was realised with dynamic frequency trading.The proposed intelligent framework can be applied to any energy systems with integrated solar PVs and BESS,where the adopted trading mechanism are associated with the system design and operation.The findings offer a practical tool for academics,investors,and policy makers to collaborate in the deployment of renewable energy and energy storage to accelerate the decarbonisation of energy supply.展开更多
The penetration level of distributed energy resources(DERs)is increasing and has significant impact on the voltage stability of distribution networks.Based on the various types of DERs with distinct reactive power cha...The penetration level of distributed energy resources(DERs)is increasing and has significant impact on the voltage stability of distribution networks.Based on the various types of DERs with distinct reactive power characteristics(RPC),their different contributions to the system voltage stability require classification.Firstly,the features of DERs are reviewed and classified based on their RPC,to investigate different distributed generation technologies for reactive power support in distribution networks.Then,the concept of a relative available transmission capacity index(RATCI),which is based on power transfer margin of the power-voltage curve considering the non-negligible distribution network resistance,is proposed to quantify and evaluate the voltage stability by integrating DERs with the defined reactive power types.Case studies have been conducted for an IEEE 33-bus distribution network to calculate the system RATCI for the mixed integration of DERs.Results show that the multitype and multi-locational integration of DERs can improve the voltage stability of a distribution network.展开更多
The Atomic Weapons Establishment(AWE) is tasked with supporting Continuous At Sea Deterrence(CASD) by certifying the performance and safety of the national deterrent in the Comprehensive Test Ban Treaty(CTBT) era. Thi...The Atomic Weapons Establishment(AWE) is tasked with supporting Continuous At Sea Deterrence(CASD) by certifying the performance and safety of the national deterrent in the Comprehensive Test Ban Treaty(CTBT) era. This means that recourse to further underground testing is not possible, and certification must be achieved by supplementing the historical data with the use of computer calculation. In order to facilitate this, AWE operates some of the largest supercomputers in the UK. To validate the computer codes, and indeed the designers who are using them, it is necessary to carry out further experiments in the right regimes. An excellent way to meet many of the requirements for material property data and to provide confidence in the validity of the algorithms is through experiments carried out on high power laser facilities.展开更多
Natural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug discovery.The unique marine environment brings us a large group of sulfur-con...Natural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug discovery.The unique marine environment brings us a large group of sulfur-containing natural products with abundant biological functionality including antitumor,antibiotic,anti-inflammatory and antiviral activities.We reviewed all the 484 sulfur-containing natural products(non-sulfated)isolated from marine microorganisms,of which 59.9%are thioethers,29.8%are thiazole/thiazoline-containing compounds and 10.3%are sulfoxides,sulfones,thioesters and many others.A selection of 133 compounds was further discussed on their structure-activity relationships,mechanisms of action,biosynthesis,and druggability.This is the first systematic review on sulfur-containing natural products from marine microorganisms conducted from January 1987,when the first one was reported,to December 2020.展开更多
Restoration of upper extremity function poses a unique surgical challenge.With considerations ranging from ensuring appropriate skeletal support and musculotendinous and ligamentous anatomy,restoring adequate vascular...Restoration of upper extremity function poses a unique surgical challenge.With considerations ranging from ensuring appropriate skeletal support and musculotendinous and ligamentous anatomy,restoring adequate vascularity and innervation,and providing sufficient soft tissue coverage,upper extremity injuries present a diverse range of reconstructive problems.Recent history has been marked by an expansion of novel techniques for addressing these complex issues.Sophisticated modalities,such as targeted muscle reinnervation,free functional muscle transfer,and vascularized composite allotransplantation,have become some of the most powerful tools in the armamentarium of the reconstructive surgeon.This review article aims to define the distinguishing features of each of these modalities and reviews some of their unique advantages and limitations.展开更多
文摘BACKGROUND Orthopaedic surgical education has traditionally depended on the apprenticeship model of“see one,do one,teach one”.However,reduced operative exposure,stricter work-hour regulations,medicolegal constraints,and patient safety concerns have constrained its practicality.Simulation-based training has become a reliable,safe,and cost-efficient alternative.Dry lab techniques,especially virtual and augmented reality,make up 78%of current dry lab research,whereas wet labs still set the standard for anatomical realism.AIM To evaluate the effectiveness,limitations,and future directions of wet and dry lab simulation in orthopaedic training.METHODS A scoping review was carried out across four databases-PubMed,Cochrane Library,Web of Science,and EBSCOhost-up to 2025.Medical Subject Headings included:"Orthopaedic Education","Wet Lab","Dry Lab","Simulation Training","Virtual Reality",and"Surgical Procedure".Eligible studies focused on orthopaedic or spinal surgical education,employed wet or dry lab techniques,and assessed training effectiveness.Exclusion criteria consisted of non-English publications,abstracts only,non-orthopaedic research,and studies unrelated to simulation.Two reviewers independently screened titles,abstracts,and full texts,resolving discrepancies with a third reviewer.RESULTS From 1851 records,101 studies met inclusion:78 on dry labs,7 on wet labs,4 on both.Virtual reality(VR)simulations were most common,with AI increasingly used for feedback and assessment.Cadaveric training remains the gold standard for accuracy and tactile feedback,while dry labs-especially VR-offer scalability,lower cost(40%-60%savings in five studies),and accessibility for novices.Senior residents prefer wet labs for complex tasks;juniors favour dry labs for basics.Challenges include limited transferability data,lack of standard outcome metrics,and ethical concerns about cadaver use and AI assessment.CONCLUSION Wet and dry labs each have unique strengths in orthopaedic training.A hybrid approach combining both,supported by standardised assessments and outcome studies,is most effective.Future efforts should aim for uniform reporting,integrating new technologies,and policy support for hybrid curricula to enhance skills and patient care.
基金the National Key Research and Development Program of China(2023YFD1700500)the College Student Research Training Program(202110307002T)Bayer Grants4Ag Initiative for their support.
文摘Developing novel anti-infective drugs is essential to combat antimicrobial resistance,address emerging pathogens,and safeguard global health against evolving infectious threats.A recent publication in the esteemed journal Nature by Qisen Deng et al.reported on the comprehensive evaluation of the therapeutic efficacy of mandimycin against multidrug-resistant(MDR)fungal pathogens.The polyene macrolide antifungal antibiotic,mandimycin,was discovered using a phylogeny-guided natural-product discovery platform.Authors utilized various in vivo mouse models such as systemic and soft-tissue infections to assess the antifungal activity of mandimycin.The efficacy was measured by quantifying the fungal burden in major organs and assessing survival rates.In systemic infections,mandimycin demonstrated significant dose-dependent antifungal efficacy,as compared to amphotericin B,particularly in cases where the latter was ineffective against MDR C.auris.Furthermore,mandimycin showed a favorable safety profile,with low toxicity and no observed side effects at effective doses.The study's findings contribute valuable insights into the potential of mandimycin as a novel antifungal agent,offering hope for improved treatment options against challenging fungal infections.The results pave the way for further research and clinical applications in the fight against antifungal resistance.
基金funded by a Christenson Professorship in Active Healthy Livingfunded by the Health Sciences TD Bank Undergraduate Research Awardsupport from the FIFA Female Athlete Project
文摘Background Relative energy deficiency in sport(REDs)results from exposure to problematic low energy availability.It is a serious condition affecting the health and athletic performance of up to 80%of elite female athletes.REDs is established to have negative short-term effects on reproductive function,but the long-term impact of this condition is unknown.Therefore,we examined the impact of secondary amenorrhea with or without a concurrent diagnosis of REDs on perinatal health outcomes.Methods Postpartum individuals(≥18 years of age)completed an online questionnaire that covered demographics,reproductive history(including a diagnosis of REDs or secondary amenorrhea),and maternal/fetal health outcomes.Logistic regression was used to determine the relationship between previously diagnosed REDs or secondary amenorrhea with perinatal health outcomes.Results A total of 1025 previously pregnant participants completed the survey(33.1±3.4 years,mean±SD).Prior to pregnancy,6.1%had been previously diagnosed with REDs and 20.5%had a history with secondary amenorrhea.Individuals diagnosed with REDs had 3.5-times higher odds of having premature labor(odds ratio,(OR)=3.52,95%confidence interval(95%CI):1.26–9.81)and 2.6-times higher odds of preterm delivery(OR=2.62,95%CI:1.05–6.58)compared to those who had not experienced REDs or secondary amenorrhea.However,in individuals who did not have a history of REDs,secondary amenorrhea did not increase the odds of adverse pregnancy or delivery outcomes.Conclusion A history of REDs,but not secondary amenorrhea,may increase the odds of premature labor and preterm delivery.
基金supported by the National Key Research and Development Program of China (2023YFF1305203)the National Natural Science Foundation of China (42477340)+2 种基金the Special Fund for Youth Team of Southwest University (SWUXDJH202306)the Southwest University Graduate Student Research and Innovation Program (SWUS24098)funded by the UK Research and Innovation–Biotechnology and Biological Sciences Research Council (UKRIBBSRC) via grant award BB/X010961/1 (Resilient Farming Futures) – specifically work package 2 BBS/E/RH/230004B
文摘The hilly purple soil area is a major grainproducing region in southwestern China,where noticeable land use change has occurred along with socio-economic development over recent decades.Degradation of ecosystem services(ESs)is therefore widespread.Understanding the interactions among ESs in the case of anthropogenic disturbance and environmental change is needed for sustainable land management.Here,we analyze the synergies/tradeoffs and bundles between ESs in this region between 1990-2015.By using the InVEST model,Geo-Detector method,and multi-source datasets,we investigated the socio-ecological drivers that dominate the dynamics of ESs.We found that ESs exhibit divergent temporal trends;food production shows a rising trend,habitat quality a declining trend,and water yield a highly variable response.Provisioning services,especially food production,have common and enduring trade-offs with other ESs.Mutual transformation occurred between ES bundles with water related ES bundles experiencing a weakness in synergistic effects.ESs that are predominantly driven by ecological drivers have gradually become controlled by social drivers which suggests the impacts of human activities in ESs are gradually increasing.Thus,integrated management policies such as land consolidation are needed to coordinate management.This study provides strategies based on ES bundles with different functional and management priorities.Also,integrating vertical zoning into land management to ensure sustainable agricultural production in lowland basins.
基金supported by the UK-China Research and Innovation Partnership Fund through the Met Office Climate Science for Service Partnership(CSSP)China as part of the Newton Fund。
文摘Extreme Mei-yu rainfall(MYR)can cause catastrophic impacts to the economic development and societal welfare in China.While significant improvements have been made in climate models,they often struggle to simulate local-to-regional extreme rainfall(e.g.,MYR).Yet,large-scale climate modes(LSCMs)are relatively well represented in climate models.Since there exists a close relationship between MYR and various LSCMs,it might be possible to develop causality-guided statistical models for MYR prediction based on LSCMs.These statistical models could then be applied to climate model simulations to improve the representation of MYR in climate models.In this pilot study,it is demonstrated that skillful causality-guided statistical models for MYR can be constructed based on known LSCMs.The relevancy of the selected predictors for statistical models are found to be consistent with the literature.The importance of temporal resolution in constructing statistical models for MYR is also shown and is in good agreement with the literature.The results demonstrate the reliability of the causality-guided approach in studying complex circulation systems such as the East Asian summer monsoon(EASM).Some limitations and possible improvements of the current approach are discussed.The application of the causality-guided approach opens up a new possibility to uncover the complex interactions in the EASM in future studies.
基金This work is funded by ERC advanced project FLAME(Flow of Ancient Metal Across Eurasia,670010),Social Science Research Fund of Shaanxi Province China(2014H02)academic fund of Wolfson College(University of Oxford).
文摘Tianshanbeilu is the largest Bronze Age site in eastern Xinjiang, China. Stretching across the entire second millennium BC, it performed a prominent role in connecting the Hexi corridor, Central China and the steppe. A further insight into the metallurgical tradition and the metal supply network is of vital importance to improve our understanding of its multi-connected nature. This paper offers a new set of chemical and isotopic data on the copper-based objects at Tianshanbeilu, including alloying elements, trace elements(impurities) and lead isotopes. Combining the concentrations of arsenic and antimony reveals that arsenic was introduced to copper partially due to the use of specific minerals tethrahedrite-tennantite. Lead isotopes demonstrate that multiple sources of copper were employed at Tianshanbeilu and a majority of them are characterized by common lead, which appears rather different from those of the Central Plains and the Hexi corridor, but highly consistent with local ores. Surprisingly, one object at Tianshanbeilu contains the well-known highly radiogenic lead. This object undoubtedly marks the westernmost boundary of the distribution of the highly radiogenic lead. We also anticipate that more lead isotopic analyses in NW China will further contribute to the study of the highly radiogenic lead in Central China.
文摘High quality polytene chromosome maps （n=3） of a Himalayan Simuliid Simulium praelargum Datta, 1973 are presented and represent the first cytological description of a taxon found in the feuerborni group, subgenus Nevermannia. Polytene chromosomes one （I） and two （II） are metacentric, chromosome three （III） is submetacentric with the length of each chromosome occupying 37.25 %, 31.36 % and 31.34 % of the total complement length, respectively. Typical simuliid diagnostic intergeneric chromosomal markers are found within the polytene complement of this species. The nucleolar organizer （N.O.） is found at the base of the short arm of chromosome one （IS）, the Ring of Balbiani （R.B.）, double bubble （D.B.） and triad occur in the short arm of chromosome two （IIS）, the Parabalbiani Ring （EB.） and grey band （gb） occur in the long arm of chromosome two （IIL） and the Blister （BL） and Capsule （Ca） occur in the short arm of chromosome three （IIIS）.Terminal bands at the end of IIIS are heterochromatinized and present atypically with respect to other simuliid fauna. Populations studied so far are unique among the Simuliidae in that they exhibit chromosome structural monomorphism. These high resolution polytene chromosome maps will form the basis for future cytological characterization and phylogenetic comparisons amongst members of the feuerborni group
基金the Start-Up Research Grant of Shenzhen University[20200807163056003]the Start-Up Research Grant[Peacock Plan:20191105534C].
文摘Emerging adulthood(EA)is a critical stage of life to develop and sustain a healthy lifestyle,which is also a time of vulnerability to poor physical and mental health outcomes.In this study,we conducted a path analysis(N=1326)to examine associations among four dimensions of EA,levels of regular physical activity(PA),self-control,MPA tendency and irrational procrastination.Results found:1)higher levels of PA predicted both MPA tendency(β=−0.08,95%CI:−0.11 to−0.06,p<0.001)and irrational procrastination(β=−0.01,95%CI:−0.17 to−0.008,p<0.01)indirectly via self-control;2)Instability(β=0.13,95%CI:0.08 to 0.18,p<0.01)and Responsibility(β=−0.06,95%CI:−0.10 to−0.08,p=0.03)exerted direct effects on irrational procrastination and Instability also indirectly predicted irrational procrastination via MPA tendency(β=0.03,95%CI:0.02 to 0.05,p<0.01).These findings proved that perceived features of EA are linked to behavioral problems and supported that regular PA plays a crucial role to protect mental health.
基金funded by the National Natural Science Foundation of China(No.41771291)the Jiangsu Agricultural Science and Technology Innovation Fund,China(No.CX(21)3183)+1 种基金the Jiangsu Specially Appointed Professor Program,Chinathe Jiangsu Six Talent Peaks Program,China(No.NY-083)。
文摘Rice fields are a major source of greenhouse gases,such as nitrous oxide (N_(2)O) and methane (CH_(4)).Organic fertilizers may potentially replace inorganic fertilizers to meet the nitrogen requirement for rice growth;however,the simultaneous effects of organic fertilizers on N_(2)O and CH_(4)emissions and crop yield in paddy fields remain poorly understood and quantified.In this study,experimental plots were established in conventional double-cropping paddy fields in the Pearl River Delta,China,including an unfertilized control and five fertilizer treatments with fresh organic fertilizer (FOF),successively composted organic fertilizer (SOF),chemically composted organic fertilizer (COF),COF supplemented with inorganic fertilizer (COIF),and chemical fertilizers (CFs)(TFOF,TSOF,TCOF,TCOIF,and TCF,respectively).Paddy field soils behaved simultaneously as an N_(2)O sink (cumulative N_(2)O emission:-196 to-381 g N ha^(-1)) and as a CH_(4)source (cumulative CH_(4)emission:719 to 2 178 kg ha^(-1)).Compared to CFs,the effects of organic fertilizers on N_(2)O emission were not significant.In contrast,total annual CH_(4)emission increased by 157%,132%,125%,and 37%in TFOF,TCOF,TSOF,and TCOIF,respectively,compared to TCF.In TCOIF,rice yield was maintained,while CH_(4)emission was not significantly increased from the paddy fields characterized by a prolonged flood period.An important next step is to extend these field-based measurements to larger rice cultivation areas to quantify the regional and national-scale impacts on greenhouse gas emissions and to help determine the optimum practice for fertilizer use.
文摘AIM To investigate the potential effect of inhibitors of phosphodiesterase-5(PDE-5) for therapy of portal hypertension in liver cirrhosis.METHODS In the rat model of thioacetamide-induced liver fibrosis/cirrhosis the nitric oxide-cyclic guanosine monophosphate(NO-cGMP) pathway was investigated. Expression and localization of PDE-5, the enzyme that converts vasodilating cGMP into inactive 5'-GMP, was in the focus of the study. Hepatic gene expression of key components of the NO-cGMP pathway was determined by qRT-PCR: Endothelial NO synthase(eNOS), inducible NO synthase(iNOS), soluble guanylate cyclase subunits α1 and β1(sGCa1, sGCb1), and PDE-5. Hepatic PDE-5 protein expression and localization were detected by immunohistochemistry. Serum cGMP concentrations were measured using ELISA. Acute effects of the PDE-5 inhibitor Sildenafil(0.1 mg/kg or 1.0 mg/kg) on portal and systemic hemodynamics were investigated using pressure transducers.RESULTS Hepatic gene expression of eNOS(2.2-fold; P = 0.003), sGCa1(1.7-fold; P = 0.003), sGCb1(3.0-fold; P = 0.003), and PDE-5(11-fold; P = 0.003) was increased in cirrhotic livers compared to healthy livers. Overexpression of PDE-5(7.7-fold; P = 0.006) was less pronounced in fibrotic livers. iNOS expression was only detected in fibrotic and cirrhotic livers. In healthy liver, PDE-5 protein was localized primarily in zone 3 hepatocytes and to a lesser extent in perisinusoidal cells. This zonation was disturbed in cirrhosis: PDE-5 protein expression in perisinusoidal cells was induced approximately 8-fold. In addition, PDE-5-expressing cells were also found in fibrous septa. Serum cGMP concentrations were reduced in rats with cirrhotic livers by approximately 40%. Inhibition of PDE-5 by Sildenafil caused a significant increase in serum cGMP concentrations [+ 64% in healthy rats(P = 0.024), + 85% in cirrhotic rats(P = 0.018)]. Concomitantly, the portal venous pressure was reduced by 19% in rats with liver cirrhosis. CONCLUSION Overexpression and abrogated zonation of PDE-5 likely contribute to the pathogenesis of cirrhotic portal hypertension. PDE-5 inhibition may therefore be a reasonable therapeutic approach for portal hypertension.
基金funded by the National Natural Science Foundation of China(No.41771291)the Agricultural Science and Technology Innovation Fund of Jiangsu,China(No.CX(21)3183)+2 种基金the Specially-Appointed Professor Program of Jiangsu,Chinathe Six Talent Peaks Project in Jiangsu Province,China(No.NY-083)the Startup Foundation for Introducing Talent of NUIST,China。
文摘Ammonia(NH_(3)) volatilization from rice fields contributes to poor air quality and indicates low nitrogen use efficiency. Although organic fertilizers can meet the nitrogen requirement for rice growth, the simultaneous effects of organic fertilizers on NH_(3) volatilization and rice yield in paddy fields are poorly understood and quantified. To address this gap in our knowledge, experimental field plots were established in a conventional double-cropping paddy field in the Pearl River Delta region, southern China. Five fertilizer treatments were used besides the control with no fertilizer: fresh organic fertilizer, successively composted organic fertilizer, chemically composted organic fertilizer, mixture of chemically composted organic fertilizer with inorganic fertilizer, and chemical fertilizer. Ammonia volatilization was measured using a batch-type airflow enclosure method. No significant differences in grain yield were observed among organic and chemical fertilizer treatments. However, compared with chemical fertilizer, chemically composted organic fertilizer and successively composted organic fertilizer significantly decreased total NH_(3) volatilization by 70% and 68%, respectively. The ammonium-nitrogen concentration in field surface water correlated strongly(P < 0.01) and positively with NH_(3) volatilization across fertilization treatments. Our findings demonstrate that chemically composted organic fertilizer can sustain rice yield while reducing NH_(3) volatilization. An important future step is to promote these field measurements to similar rice cultivation areas to quantify the regional-and national-scale impact on air quality and nitrogen deposition in sensitive areas, and to design and implement better fertilizer management practices.
基金Universiti Kebangsaan Malaysia’s research university grant scheme (DCP-2017- 003/4)。
文摘This study focused on the encapsulation of vancomycin(VAN) into liposomes coated with a red blood cell membrane with a targeting ligand, daptomycin–polyethylene glycol–1,2-distearoyl-sn-glycero-3-phosphoethanolamine, formed by conjugation of DAPT and Nhydroxysuccinimidyl-polyethylene glycol-1,2-distearoyl-sn-glycero-3-phosphoethanolamine.This formulation is capable of providing controlled and targeted drug delivery to the bacterial cytoplasm. We performed MALDI-TOF, NMR and FTIR analyses to confirm the conjugation of the targeting ligand via the formation of amide bonds. Approximately 45% of VAN could be loaded into the aqueous cores, whereas 90% DAPT was detected using UV–vis spectrophotometry. In comparison to free drugs, the formulations controlled the release of drugs for > 72 h. Additionally, as demonstrated using CLSM and flow cytometry, the resulting formulation was capable of evading detection by macrophage cells. In comparison to free drugs, red blood cell membrane–DAPT–VAN liposomes, DAPT liposomes, and VAN liposomes reduced the MIC and significantly increased bacterial permeability, resulting in > 80% bacterial death within 4 h. Cytotoxicity tests were performed in vitro and in vivo on mammalian cells,in addition to hemolytic activity tests in human erythrocytes, wherein drugs loaded into the liposomes and RBCDVL exhibited low toxicity. Thus, the findings of this study provide insight about a dual antibiotic targeting strategy that utilizes liposomes and red blood cell membranes to deliver targeted drugs against MRSA.
文摘Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway.
基金funded jointly by the Natural Science Foundation of Fujian Province,China(Grant Nos.2022R1002006 and 2022R1002007)Graduate Innovation Foundation of School of Geographical Sciences,Fujian Normal University,the National Natural Science Foundation of China(Grant Nos.42371100 and 41801070)Henan Province Science Foundation for Youths of China(Grant Nos.232300421256).
文摘Labile organic carbon(LOC)plays a pivotal role in soil biogeochemistry and ecological functions.China’s coastal wetlands have been profoundly impacted due to plant invasion and land use change,but the effects on soil LOC quantity and composition are unclear.This study analyzed the soil LOC components—namely,dissolved organic carbon(DOC),easily oxidizable carbon(EOC),and microbial biomass carbon(MBC)—across twenty-one coastal wetlands in southeastern China.These wetlands underwent a uniform land cover transition from native mudflats(MFs)to Spartina alterniflora marshes(SAs),and eventually to aquaculture ponds(APs).The results indicated that EOC was the dominant component of soil organic carbon(SOC)(57.5%–61.6%),followed by MBC(3.5%–4.5%)and DOC(<0.5%).The transition from MFs to SAs led to a rise in mean EOC and DOC by 18.6%and 41.4%,respectively.Subsequent conversion of SAs to APs resulted in a reduction in mean EOC and DOC by 5.9%and 20.3%,respectively.MBC did not differ significantly among habitat types.Total nitrogen availability was the main driver of changes in LOC across both land cover change scenarios.The mineralization rate of SOC were more strongly correlated with DOC than EOC and MBC.Microbial turnover of EOC was temperature dependent across the geographical range.These finds highlighted that plant invasion and land use change affected LOC fractions and subsequent SOC stability and carbon emissions in coastal wetlands.
基金This work was supported by the New Century Higher Education Teaching Reform Project of Sichuan University under Grant SCU8007and the Inter-disciplinary Training Project for Talents of Sichuan University under grant SCUKG056.
文摘Over the past decades,both agriculture and power systems have faced serious problems,such as the power supply shortage in agriculture,and difficulties of clean energy consump-tion in the power system.To address and overcome these issues,this paper proposes an idea to combine smart agriculture and clean energy consumption,use surplus clean energy to supply agriculture production,and utilize smart agriculture to support power system with clean energy penetration.A comprehensive review has been conducted to first depict the roadmap of coupling a agriculture-clean energy system,analyze their feasibilities and advantages.The recent technologies and bottlenecks are summa-rized and evaluated for the development of a combined system consisting of smart agriculture production and clean energy consumption.Several case studies are introduced to explore the mutual benefits of agriculture-clean energy systems in both the energy and food industries.
基金support of the Engineering and Physical Sciences Research Council(EPSRC)of the United Kingdom(Grant No EP/V041665/1).
文摘Local energy systems are undergoing significant transformation by integrating more solar photovoltaics(PVs)and battery energy storage systems(BESS)to achieve net-zero targets in the energy sector.To ensure an affordable and sustainable decarbonisation process,optimising both system design and operation together is crucial for maximising system profitability and encouraging broader stakeholder participation in the energy transition.However,the complex interdependent influence on the system economic flows,along with the nonlinear characteristics of the system,make the economic optimisation extremely challenging.To address this,we developed a new framework based on advanced artificial intelligence to exploit a wider arbitrage margin under various trading mechanisms,including net metering,day-ahead,and dynamic frequency.We conducted optimisation study on a local energy system operating at University of Warwick using real data from demonstrated BESS and solar PVs,and the effectiveness of the proposed intelligent approach was validated,and the necessity of interdependent optimisation was highlighted.Results showed that,compared to the original campus system(20 MW-level),a carbon reduction rate of up to 61.4%was achieved through net metering trading,while a maximum annual profit increase of 251%was realised with dynamic frequency trading.The proposed intelligent framework can be applied to any energy systems with integrated solar PVs and BESS,where the adopted trading mechanism are associated with the system design and operation.The findings offer a practical tool for academics,investors,and policy makers to collaborate in the deployment of renewable energy and energy storage to accelerate the decarbonisation of energy supply.
基金supported by National Natural Science Foundation of China(No.51807127)the Fundamental Research Funds for the Central Universities of China(YJ201654)the Open Research Subject of Key Laboratory of Sichuan Power Electronics Energy-saving Technology and Devices(szjj2017-052).
文摘The penetration level of distributed energy resources(DERs)is increasing and has significant impact on the voltage stability of distribution networks.Based on the various types of DERs with distinct reactive power characteristics(RPC),their different contributions to the system voltage stability require classification.Firstly,the features of DERs are reviewed and classified based on their RPC,to investigate different distributed generation technologies for reactive power support in distribution networks.Then,the concept of a relative available transmission capacity index(RATCI),which is based on power transfer margin of the power-voltage curve considering the non-negligible distribution network resistance,is proposed to quantify and evaluate the voltage stability by integrating DERs with the defined reactive power types.Case studies have been conducted for an IEEE 33-bus distribution network to calculate the system RATCI for the mixed integration of DERs.Results show that the multitype and multi-locational integration of DERs can improve the voltage stability of a distribution network.
文摘The Atomic Weapons Establishment(AWE) is tasked with supporting Continuous At Sea Deterrence(CASD) by certifying the performance and safety of the national deterrent in the Comprehensive Test Ban Treaty(CTBT) era. This means that recourse to further underground testing is not possible, and certification must be achieved by supplementing the historical data with the use of computer calculation. In order to facilitate this, AWE operates some of the largest supercomputers in the UK. To validate the computer codes, and indeed the designers who are using them, it is necessary to carry out further experiments in the right regimes. An excellent way to meet many of the requirements for material property data and to provide confidence in the validity of the algorithms is through experiments carried out on high power laser facilities.
基金This paper is dedicated to Professor Youyou Tu,the 2015 Nobel Prize Laureate of Physiology or Medicine on the occasion of her 90th Birthday.This work was supported by the Program of National Natural Science Foundation of China(Nos.U1706210,41776141 and 41322037)the Fundamental Research Funds for the Central Universities(No.201841004)+1 种基金the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(Qingdao)(No.2018SDKJ0403-2)the Taishan Scholars Program,China(No.tsqn20161010).
文摘Natural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug discovery.The unique marine environment brings us a large group of sulfur-containing natural products with abundant biological functionality including antitumor,antibiotic,anti-inflammatory and antiviral activities.We reviewed all the 484 sulfur-containing natural products(non-sulfated)isolated from marine microorganisms,of which 59.9%are thioethers,29.8%are thiazole/thiazoline-containing compounds and 10.3%are sulfoxides,sulfones,thioesters and many others.A selection of 133 compounds was further discussed on their structure-activity relationships,mechanisms of action,biosynthesis,and druggability.This is the first systematic review on sulfur-containing natural products from marine microorganisms conducted from January 1987,when the first one was reported,to December 2020.
文摘Restoration of upper extremity function poses a unique surgical challenge.With considerations ranging from ensuring appropriate skeletal support and musculotendinous and ligamentous anatomy,restoring adequate vascularity and innervation,and providing sufficient soft tissue coverage,upper extremity injuries present a diverse range of reconstructive problems.Recent history has been marked by an expansion of novel techniques for addressing these complex issues.Sophisticated modalities,such as targeted muscle reinnervation,free functional muscle transfer,and vascularized composite allotransplantation,have become some of the most powerful tools in the armamentarium of the reconstructive surgeon.This review article aims to define the distinguishing features of each of these modalities and reviews some of their unique advantages and limitations.
