The convergence of next-generation Networks and the emergence of new media systems have made media-rich digital libraries popular in application and research. The discovery of media content objects’ usage patterns, w...The convergence of next-generation Networks and the emergence of new media systems have made media-rich digital libraries popular in application and research. The discovery of media content objects’ usage patterns, where QPop Increment is the characteristic feature under study, is the basis of intelligent data migration scheduling, the very key issue for these systems to manage effectively the massive storage facilities in their backbones. In this paper, a clustering algorithm is established, on the basis of temporal segmentation of QPop Increment, so as to improve the mining performance. We employed the standard C-Means algorithm as the clustering kernel, and carried out the experimental mining process with segmented QPop Increases obtained in actual applications. The results indicated that the improved algorithm is more advantageous than the basic one in important indices such as the clustering cohesion. The experimental study in this paper is based on a Media Assets Library prototype developed for the use of the advertainment movie production project for Olympics 2008, under the support of both the Humanistic Olympics Study Center in Beijing, and China State Administration of Radio, Film and TV.展开更多
Objective:Astragalus Radix(AR,Huangqi in Chinese) has been widely used as a qi(energy) restoring herb that is thought to act through reinvigorating the spleen and lung.Aconite is used to rebalance the body temperature...Objective:Astragalus Radix(AR,Huangqi in Chinese) has been widely used as a qi(energy) restoring herb that is thought to act through reinvigorating the spleen and lung.Aconite is used to rebalance the body temperature during illness and played an irreplaceable role in disease control since ancient times,but it is limited by its strong neuro and cardiotoxicity.Since the Song Dynasty(1227),the two herbs have been commonly used as herbal pairs including in the famous Qifu Decotion,from the "Wei's Family Prescription".However,many ancient texts also record that they are not compatible using together,suggesting they can have negative outcomes when mixed.This study investigated whether Astragali Radix had either positive or negative effects on absorption of six different active alkaloids derived from aconite.Methods:Single intestinal perfusion model was used to study the effects of Astragali Radix on aconite alkaloids absorption.Response of ABC transporters and distribution of three tight junction proteins on the surface of intestinal enothelium were assessed by Reverse Transcription-Polymerase Chain Reaction(RT-PCR),Western blot and immunofluorescence microscopy,respectively.Results:The results showed that aconite alkaloids absorption could be inhibited,and different concentrations of Astragali Radix considerably increased the expression levels of the ABC transporters and tight junction proteins with Astragali Radix treatment.Conclusion:These results suggest that Astragali Radix can block absorption of aconite alkaloids through the upregulation expression of ATP-binding cassette transporters(ABC transporters) and tight junction proteins.It demonstrates that co-administration of Astragali Radix with other drugs might change the absorption profile of the second drug which is important to know in clinic therapy.展开更多
文摘The convergence of next-generation Networks and the emergence of new media systems have made media-rich digital libraries popular in application and research. The discovery of media content objects’ usage patterns, where QPop Increment is the characteristic feature under study, is the basis of intelligent data migration scheduling, the very key issue for these systems to manage effectively the massive storage facilities in their backbones. In this paper, a clustering algorithm is established, on the basis of temporal segmentation of QPop Increment, so as to improve the mining performance. We employed the standard C-Means algorithm as the clustering kernel, and carried out the experimental mining process with segmented QPop Increases obtained in actual applications. The results indicated that the improved algorithm is more advantageous than the basic one in important indices such as the clustering cohesion. The experimental study in this paper is based on a Media Assets Library prototype developed for the use of the advertainment movie production project for Olympics 2008, under the support of both the Humanistic Olympics Study Center in Beijing, and China State Administration of Radio, Film and TV.
基金supported by a grant of National Natural Science Foundation of China (No.81660757)the Project of Education Department of Jiangxi Province (No.180639)Project of Jiangxi University of TCM (No.JXSYLXK-ZHYAO081)。
文摘Objective:Astragalus Radix(AR,Huangqi in Chinese) has been widely used as a qi(energy) restoring herb that is thought to act through reinvigorating the spleen and lung.Aconite is used to rebalance the body temperature during illness and played an irreplaceable role in disease control since ancient times,but it is limited by its strong neuro and cardiotoxicity.Since the Song Dynasty(1227),the two herbs have been commonly used as herbal pairs including in the famous Qifu Decotion,from the "Wei's Family Prescription".However,many ancient texts also record that they are not compatible using together,suggesting they can have negative outcomes when mixed.This study investigated whether Astragali Radix had either positive or negative effects on absorption of six different active alkaloids derived from aconite.Methods:Single intestinal perfusion model was used to study the effects of Astragali Radix on aconite alkaloids absorption.Response of ABC transporters and distribution of three tight junction proteins on the surface of intestinal enothelium were assessed by Reverse Transcription-Polymerase Chain Reaction(RT-PCR),Western blot and immunofluorescence microscopy,respectively.Results:The results showed that aconite alkaloids absorption could be inhibited,and different concentrations of Astragali Radix considerably increased the expression levels of the ABC transporters and tight junction proteins with Astragali Radix treatment.Conclusion:These results suggest that Astragali Radix can block absorption of aconite alkaloids through the upregulation expression of ATP-binding cassette transporters(ABC transporters) and tight junction proteins.It demonstrates that co-administration of Astragali Radix with other drugs might change the absorption profile of the second drug which is important to know in clinic therapy.
