Stereotactic ablative body radiotherapy(SABR)is an effective technique comparable to surgery in terms of local control and efficacy in early stages of non-small cell lung cancer(NSCLC)and pulmonary metastasis.Several ...Stereotactic ablative body radiotherapy(SABR)is an effective technique comparable to surgery in terms of local control and efficacy in early stages of non-small cell lung cancer(NSCLC)and pulmonary metastasis.Several fractionation schemes have proven to be safe and effective,including the single fraction(SF)scheme.SF is an option costeffectiveness,more convenience and comfortable for the patient and flexible in terms of its management combined with systemic treatments.The outbreak of the severe acute respiratory syndrome coronavirus 2 pandemic has driven this not new but underutilized paradigm,recommending this option to minimize patients’visits to hospital.SF SABR already has a long experience,strong evidence and sufficient maturity to reliably evaluate outcomes in peripheral primary NSCLC and there are promising outcomes in pulmonary metastases,making it a valid treatment option;although its use in central locations,synchronous and recurrencies tumors requires more prospective safety and efficacy studies.The SABR radiobiology study,together with the combination with systemic therapies,(targeted therapies and immunotherapy)is a direction of research in both advanced disease and early stages whose future includes SF.展开更多
As part of the development work of the Chinese new regional climate model (RIEMS), the radiative process of black carbon (BC) aerosols has been introduced into the original radiative procedures of RIEMS, and the trans...As part of the development work of the Chinese new regional climate model (RIEMS), the radiative process of black carbon (BC) aerosols has been introduced into the original radiative procedures of RIEMS, and the transport model of BC aerosols has also been established and combined with the RIEMS model. Using the new model system, the distribution of black carbon aerosols and their radiative effect over the China region are investigated. The influences of BC aerosole on the atmospheric radiative transfer and on the air temperature, land surface temperature, and total rainfall are analyzed. It is found that BC aerosols induce a positive radiative forcing at the top of the atmosphere (TOA), which is dominated by shortwave radiative forcing. The maximum radiative forcing occurs in North China in July and in South China in April. At the same time, negative radiative forcing is observed on the surface. Based on the radiative forcing comparison between clear sky and cloudy sky, it is found that cloud can enforce the TOA positive radiative forcing and decrease the negative surface radiative forcing. The responses of the climate system in July to the radiative forcing due to BC aerosols are the decrease in the air temperature in the middle and lower reaches of the Changjiang River and Huaihe area and most areas of South China, and the weak increase or decrease in air temperature over North China. The total rainfall in the middle and lower reaches of the Changjiang River area is increased, but it decreased in North China in July.展开更多
The main features of top-flcor rooms with natural ventilation are identified by investigating indoor thermal environment in summer season. One is high indoor air temperature, for this reason the indoor climate is far ...The main features of top-flcor rooms with natural ventilation are identified by investigating indoor thermal environment in summer season. One is high indoor air temperature, for this reason the indoor climate is far beyond the thermal comfort standard; the other is the inhomogeneons temperature distribution of the inner wall surfaces, and high temperature of the inner surface of the roof causes much scorching to the head of occupant. This is the characteristic of such rooms. Both features mentioned above should be considered comprehensively for the evaluation of indoor thermal environment of the top-floor rooms with asymmetric radiant field. In order to characterize the indoor thermal environment of the rooms, the heat stress index, HSI and radiant heat flux reaching human head, Q_R should be introduced simultaneously as thermal indexes for the indoor climate evaluation. The application of the indexes to a topfloor room is presented and analyzed.展开更多
Traditional Chinese Medicines （TCMs） have been em-ployed for centuries in the treatment of patients with hepatocellular carcinoma （HCC）. Previous reviews of this topic have focused on certain aspects of TCM treatm...Traditional Chinese Medicines （TCMs） have been em-ployed for centuries in the treatment of patients with hepatocellular carcinoma （HCC）. Previous reviews of this topic have focused on certain aspects of TCM treatment rather than an overall assessment of their value and mechanisms of action. Both the Chinese and English medical literatures were reviewed to identify where TCM might be of value in the treatment of HCC and the justifcation for such treatment. TCM treatment corrects the “internal disequilibriums” thought to be responsible for the development, growth, and spread of the tumor. It has also been used to manage symptoms associa-ted with HCC and the adverse effects of chemo- and radiation-therapies. Recent research has documented the precise effects of TCM on tumor biology. There are also increasing efforts to identify which of the many components of TCM herbal remedies are primarily res-ponsible for these beneficial effects. This review out-lines the benefits of TCM treatment of HCC and the laboratory data describing their anti-tumor properties.展开更多
Since Einstein Observatory published quasar’s data, many astronomers have paid much attention on the correlations among X-ray, optical and radio radiation. Investigating the above correlations is not only the key to ...Since Einstein Observatory published quasar’s data, many astronomers have paid much attention on the correlations among X-ray, optical and radio radiation. Investigating the above correlations is not only the key to calculating X-ray back-ground radiation, but also an important method for studying the radiative mechan-isms on the above three wavebands. A spectacular work done by Tananbaum et al.展开更多
Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previ...Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy.展开更多
Extensive neurodegeneration is a hallmark of traumatic spinal cord injury (SCI) that underlies permanent sensorimotor and autonomic impairments (Alizadeh et al.,2019).Following the primary impact,the spinal cord under...Extensive neurodegeneration is a hallmark of traumatic spinal cord injury (SCI) that underlies permanent sensorimotor and autonomic impairments (Alizadeh et al.,2019).Following the primary impact,the spinal cord undergoes a cascade of secondary injury mechanisms that are driven by disruption of the blood-spinal cord ba rrier,vascula r inju ry,glial reactivity,neu roinfla mmation,oxidative stress,lipid peroxidation,and glutamate excitotoxicity that culminate in neuronal and oligodendroglial cell death,demyelination,and axonal damage(Alizadeh et al.,2019).To achieve a meaningful functional recovery after SCI,regeneration of new neurons and oligodendrocytes and their successful growth and integration within the neural network are critical steps for reconstructing the damaged spinal cord tissue (Fischer et al.,2020).展开更多
Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,Sou...Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North America.Since old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.展开更多
Background: First responders (firefighters, paramedics, and police) working in an urban setting can be exposed to a high-stress environment caused by strenuous physical exertion, potentially dangerous work conditions,...Background: First responders (firefighters, paramedics, and police) working in an urban setting can be exposed to a high-stress environment caused by strenuous physical exertion, potentially dangerous work conditions, sleep deprivation due to shift work, poor dietary habits, psychological stress and noise levels that are excessive. This may induce chronic increases in blood pressure. The purpose of this study was to determine the presence of hypertension in people working in occupations generally accepted as high stress in comparison to those working in an environment where less of these obvious high stressors were present. Methods: Resting blood pressure was measured by TrUBP in 1067 on-duty first responders (fire, paramedic, and police), and in participants generally associated with a lower-stress work environment (transit workers, city and bank employees, factory workers and legislature employees). Results: The average age, systolic and diastolic blood pressures were significantly lower in those employees working in a high-stress environment than those in a low-stress job. This difference was observed in both male and female sexes. Conclusions: Our data do not support an association of high resting blood pressure values in those employed in activities typically associated with a high-stress urban working environment.展开更多
Reflecting on 16 years of continuous evolution at the World Journal of Stem Cells,this editorial offers a forward-looking vision for redefining the framework of scientific publishing.With the emergence of artificial i...Reflecting on 16 years of continuous evolution at the World Journal of Stem Cells,this editorial offers a forward-looking vision for redefining the framework of scientific publishing.With the emergence of artificial intelligence,open science,and the growing need for translational value,we propose shifting from traditional citation-based assessments toward an impact and progress framework,anchored by the Economic Impact Factor.The World Journal of Stem Cells experience,grounded in metrics and milestones,supports this evolution:Among the more than 1200 published articles since inception,our top 10 cited works have collectively accrued over 2475 citations,led by Kyurkchiev et al(398 citations)and Casteilla et al(392 citations).Emerging scholars such as Ann De Becker and Nipha Chaicharoenaudomrung have shaped the next generation of research,as seen in our top 10 junior authors table.Clinically,World Journal of Stem Cells has supported critical translational work,such as Tsang et al’s mesenchymal stem cell stroke trial(27 citations),illustrating real-world impact.Thematic breadth remains a cornerstone,with 22 focus areas including artificial intelligence-integrated programming,spatial single-cell biology,CRISPR-based gene editing,and bench-to-bedside translation.As Nature and other leading publishers move toward transparent peer review,World Journal of Stem Cells embraces editorial co-creation,recognizing peer reviewers and editors as contributors with“10000-foot eagle views”by publishing peer-review reports side-by-side with the related manuscripts since its inception.Together,these shifts signify a call to recalibrate what we value in science-not just what is cited,but what truly counts.展开更多
Conventional agrochemical plant biostimulants have been used to increase crop yield and stress resistance,andthis strategy continues to be integral to today's farming.While effective,the large-scale implantations ...Conventional agrochemical plant biostimulants have been used to increase crop yield and stress resistance,andthis strategy continues to be integral to today's farming.While effective,the large-scale implantations of theseproducts are not without environmental,ecological,and cost concerns and the associated climate-change challenges.To alleviate this long-standing pressure on agriculture,designing and developing more biocompatible andsustainable plant stimulants are among the primary focuses of agricultural management.Over the recent decades,the field has witnessed significant progress in emerging naturally derived or nature-inspired nano-biostimulantswith large-active-surface areas,including bio-compounds,biopolymers,and nanocarbons.However,the extraction/preparation of these products may apply additional costs or require specific equipment.More recently,thefield's attention has shifted to the sustainable application of chemical-additive-free biostimulants towards practicalapplications in nano-agriculture.Herein,we rationally designed and reported the first evidence and elucidationon biostimulant impacts of plant-self-derived nano-extracts from donor Arabidopsis thaliana as a model forinducing mirror biostimulant activities in conspecific host seeds,seedlings,and plants.Moreover,we assessed theeffect of donor plants'age on short,mid-,and long-term biocompatibility,growth,and development/maturationof the recipient plants for up to around 30 days.As a proof-of-concept,we found these autologous bio-extractscould effectively promote seed sprouting,seedling germination,and the development of soil-drenched plantsof the same types.Our transmission-electron microscopy characterization of root/shoot pieces shows the presenceof multiple phyto-compounds,including microtubules/actin filaments,cell vacuoles,Golgi stacks/endoplasmicreticulum,cell wall polysaccharide-based cellulose fibers,and organic amorphous nanoparticles and clusters ofcarbon quantum dots in the structure of these extracts.This personalized plant stimulation may induce furthergrowth/defense-related mechanisms,setting new paradigms toward reducing the agrochemical inputs.展开更多
2022年12月美国儿科学会发布了新生儿重症监护室(neonatal intensive care unit,NICU)床旁即时超声检查(point-of-care ultrasonography,POCUS)的临床方案。该方案概述了NICU中POCUS的发展和现状,并对NICU顺利开展POCUS的核心要素和实...2022年12月美国儿科学会发布了新生儿重症监护室(neonatal intensive care unit,NICU)床旁即时超声检查(point-of-care ultrasonography,POCUS)的临床方案。该方案概述了NICU中POCUS的发展和现状,并对NICU顺利开展POCUS的核心要素和实施准则进行了总结。该文对该临床方案的要点进行了解读,并对国内POCUS的开展现状进行了分析,为国内新生儿科开展POCUS提供参考。展开更多
目的研究重复经颅磁刺激(Repetitive Transcranial Magnetic Stimulation,rTMS)对缺血性脑卒中后运动功能障碍患者的康复治疗效果及其功能影像学变化。方法纳入缺血性脑卒中患者15例,分为rTMS治疗组8例和传统康复治疗组(Conventional Th...目的研究重复经颅磁刺激(Repetitive Transcranial Magnetic Stimulation,rTMS)对缺血性脑卒中后运动功能障碍患者的康复治疗效果及其功能影像学变化。方法纳入缺血性脑卒中患者15例,分为rTMS治疗组8例和传统康复治疗组(Conventional Therapy,CT)7例;rTMS组除接受10天高频rTMS治疗外,其他治疗措施与CT组相同。治疗前和治疗后分别对两组的临床评分进行评估,并进行功能磁共振图像(Functional Magnetic Resonance Imaging,fMRI)采集,比较两组治疗前后及组间临床评分及神经活动低频振幅(Amplitude of Low Frequency Fluctuation,ALFF)的变化情况。结果与治疗前相比,治疗后两组的神经功能明显改善。rTMS组患者的FMA和BI评分改善优于CT组。另外,治疗后两组患者的ALFF比较差异有统计学意义(P<0.05)。其中ALFF值增加的脑区包括:右侧壳核、左侧小脑;ALFF值降低的脑区有:双侧M1区、双侧SMA区、右侧丘脑、右侧小脑。结论高频rTMS可以用于缺血性脑卒中后运动功能障碍患者的康复治疗,且高频rTMS可能通过影响大脑内相关区域的神经活动强度达到康复效果。展开更多
文摘Stereotactic ablative body radiotherapy(SABR)is an effective technique comparable to surgery in terms of local control and efficacy in early stages of non-small cell lung cancer(NSCLC)and pulmonary metastasis.Several fractionation schemes have proven to be safe and effective,including the single fraction(SF)scheme.SF is an option costeffectiveness,more convenience and comfortable for the patient and flexible in terms of its management combined with systemic treatments.The outbreak of the severe acute respiratory syndrome coronavirus 2 pandemic has driven this not new but underutilized paradigm,recommending this option to minimize patients’visits to hospital.SF SABR already has a long experience,strong evidence and sufficient maturity to reliably evaluate outcomes in peripheral primary NSCLC and there are promising outcomes in pulmonary metastases,making it a valid treatment option;although its use in central locations,synchronous and recurrencies tumors requires more prospective safety and efficacy studies.The SABR radiobiology study,together with the combination with systemic therapies,(targeted therapies and immunotherapy)is a direction of research in both advanced disease and early stages whose future includes SF.
基金This research was sponsored by the National Key Program for Developing Basic Sciences of China(No.G1999043400)the National Natural Science Foundation of China(Grant Nos.40205016 and 40165001).
文摘As part of the development work of the Chinese new regional climate model (RIEMS), the radiative process of black carbon (BC) aerosols has been introduced into the original radiative procedures of RIEMS, and the transport model of BC aerosols has also been established and combined with the RIEMS model. Using the new model system, the distribution of black carbon aerosols and their radiative effect over the China region are investigated. The influences of BC aerosole on the atmospheric radiative transfer and on the air temperature, land surface temperature, and total rainfall are analyzed. It is found that BC aerosols induce a positive radiative forcing at the top of the atmosphere (TOA), which is dominated by shortwave radiative forcing. The maximum radiative forcing occurs in North China in July and in South China in April. At the same time, negative radiative forcing is observed on the surface. Based on the radiative forcing comparison between clear sky and cloudy sky, it is found that cloud can enforce the TOA positive radiative forcing and decrease the negative surface radiative forcing. The responses of the climate system in July to the radiative forcing due to BC aerosols are the decrease in the air temperature in the middle and lower reaches of the Changjiang River and Huaihe area and most areas of South China, and the weak increase or decrease in air temperature over North China. The total rainfall in the middle and lower reaches of the Changjiang River area is increased, but it decreased in North China in July.
基金This work was supported by the National Natural Science Foundation for Distinguished Young Scholars (Grant No. 50125821)
文摘The main features of top-flcor rooms with natural ventilation are identified by investigating indoor thermal environment in summer season. One is high indoor air temperature, for this reason the indoor climate is far beyond the thermal comfort standard; the other is the inhomogeneons temperature distribution of the inner wall surfaces, and high temperature of the inner surface of the roof causes much scorching to the head of occupant. This is the characteristic of such rooms. Both features mentioned above should be considered comprehensively for the evaluation of indoor thermal environment of the top-floor rooms with asymmetric radiant field. In order to characterize the indoor thermal environment of the rooms, the heat stress index, HSI and radiant heat flux reaching human head, Q_R should be introduced simultaneously as thermal indexes for the indoor climate evaluation. The application of the indexes to a topfloor room is presented and analyzed.
文摘Traditional Chinese Medicines （TCMs） have been em-ployed for centuries in the treatment of patients with hepatocellular carcinoma （HCC）. Previous reviews of this topic have focused on certain aspects of TCM treatment rather than an overall assessment of their value and mechanisms of action. Both the Chinese and English medical literatures were reviewed to identify where TCM might be of value in the treatment of HCC and the justifcation for such treatment. TCM treatment corrects the “internal disequilibriums” thought to be responsible for the development, growth, and spread of the tumor. It has also been used to manage symptoms associa-ted with HCC and the adverse effects of chemo- and radiation-therapies. Recent research has documented the precise effects of TCM on tumor biology. There are also increasing efforts to identify which of the many components of TCM herbal remedies are primarily res-ponsible for these beneficial effects. This review out-lines the benefits of TCM treatment of HCC and the laboratory data describing their anti-tumor properties.
文摘Since Einstein Observatory published quasar’s data, many astronomers have paid much attention on the correlations among X-ray, optical and radio radiation. Investigating the above correlations is not only the key to calculating X-ray back-ground radiation, but also an important method for studying the radiative mechan-isms on the above three wavebands. A spectacular work done by Tananbaum et al.
基金supported by Jiangsu Hengrui Medicine Co.,Ltd[The National Natural Science Foundation of China(Grant No.81230056)The National Science&Technology Pillar Program during the Twelfth Five-year Plan Period(Grand No.2014BAI09B10+4 种基金The Natural Science Foundation of Guangdong Province(Grand Nos.S2013010012220,2017A030312003)the Science and Technology Project of Guangzhou City,China(Grand No.132000507)The Health&Medical Collaborative Innovation Project of Guangzhou City,China(Grand No.201400000001)The Innovation Team Development Plan of the Ministry of Education(Grand No.IRT_17R110)the Program of Introducing Talents of Discipline to Universities(Grand No.B14035)].
文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy.
基金funding support from the Canadian Institutes of Health Researchsupported by a Doctoral Studentship from the Wings for Life Foundation。
文摘Extensive neurodegeneration is a hallmark of traumatic spinal cord injury (SCI) that underlies permanent sensorimotor and autonomic impairments (Alizadeh et al.,2019).Following the primary impact,the spinal cord undergoes a cascade of secondary injury mechanisms that are driven by disruption of the blood-spinal cord ba rrier,vascula r inju ry,glial reactivity,neu roinfla mmation,oxidative stress,lipid peroxidation,and glutamate excitotoxicity that culminate in neuronal and oligodendroglial cell death,demyelination,and axonal damage(Alizadeh et al.,2019).To achieve a meaningful functional recovery after SCI,regeneration of new neurons and oligodendrocytes and their successful growth and integration within the neural network are critical steps for reconstructing the damaged spinal cord tissue (Fischer et al.,2020).
基金funded by the Natural Sciences and Engineering Research Council of Canada(RGPIN:2016-05964&2023-04283 to JHK)the University of Manitoba Tri-Agency Bridge Funding(#57289 to JHK)the Ricard Foundation’s Baxter Bursary(to JP)。
文摘Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North America.Since old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.
文摘Background: First responders (firefighters, paramedics, and police) working in an urban setting can be exposed to a high-stress environment caused by strenuous physical exertion, potentially dangerous work conditions, sleep deprivation due to shift work, poor dietary habits, psychological stress and noise levels that are excessive. This may induce chronic increases in blood pressure. The purpose of this study was to determine the presence of hypertension in people working in occupations generally accepted as high stress in comparison to those working in an environment where less of these obvious high stressors were present. Methods: Resting blood pressure was measured by TrUBP in 1067 on-duty first responders (fire, paramedic, and police), and in participants generally associated with a lower-stress work environment (transit workers, city and bank employees, factory workers and legislature employees). Results: The average age, systolic and diastolic blood pressures were significantly lower in those employees working in a high-stress environment than those in a low-stress job. This difference was observed in both male and female sexes. Conclusions: Our data do not support an association of high resting blood pressure values in those employed in activities typically associated with a high-stress urban working environment.
文摘Reflecting on 16 years of continuous evolution at the World Journal of Stem Cells,this editorial offers a forward-looking vision for redefining the framework of scientific publishing.With the emergence of artificial intelligence,open science,and the growing need for translational value,we propose shifting from traditional citation-based assessments toward an impact and progress framework,anchored by the Economic Impact Factor.The World Journal of Stem Cells experience,grounded in metrics and milestones,supports this evolution:Among the more than 1200 published articles since inception,our top 10 cited works have collectively accrued over 2475 citations,led by Kyurkchiev et al(398 citations)and Casteilla et al(392 citations).Emerging scholars such as Ann De Becker and Nipha Chaicharoenaudomrung have shaped the next generation of research,as seen in our top 10 junior authors table.Clinically,World Journal of Stem Cells has supported critical translational work,such as Tsang et al’s mesenchymal stem cell stroke trial(27 citations),illustrating real-world impact.Thematic breadth remains a cornerstone,with 22 focus areas including artificial intelligence-integrated programming,spatial single-cell biology,CRISPR-based gene editing,and bench-to-bedside translation.As Nature and other leading publishers move toward transparent peer review,World Journal of Stem Cells embraces editorial co-creation,recognizing peer reviewers and editors as contributors with“10000-foot eagle views”by publishing peer-review reports side-by-side with the related manuscripts since its inception.Together,these shifts signify a call to recalibrate what we value in science-not just what is cited,but what truly counts.
基金Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)grant number 525793193Prof.Stefan Eimer and Ms.Marion Basoglu at Goethe University for their assistance in TEM characterization+1 种基金Mr.Holger Schranz for his help in plant cultivation and maintenanceProf.Bruno M.Moerschbacher from the Institute of Plant Biology and Biotechnology at the Münster University。
文摘Conventional agrochemical plant biostimulants have been used to increase crop yield and stress resistance,andthis strategy continues to be integral to today's farming.While effective,the large-scale implantations of theseproducts are not without environmental,ecological,and cost concerns and the associated climate-change challenges.To alleviate this long-standing pressure on agriculture,designing and developing more biocompatible andsustainable plant stimulants are among the primary focuses of agricultural management.Over the recent decades,the field has witnessed significant progress in emerging naturally derived or nature-inspired nano-biostimulantswith large-active-surface areas,including bio-compounds,biopolymers,and nanocarbons.However,the extraction/preparation of these products may apply additional costs or require specific equipment.More recently,thefield's attention has shifted to the sustainable application of chemical-additive-free biostimulants towards practicalapplications in nano-agriculture.Herein,we rationally designed and reported the first evidence and elucidationon biostimulant impacts of plant-self-derived nano-extracts from donor Arabidopsis thaliana as a model forinducing mirror biostimulant activities in conspecific host seeds,seedlings,and plants.Moreover,we assessed theeffect of donor plants'age on short,mid-,and long-term biocompatibility,growth,and development/maturationof the recipient plants for up to around 30 days.As a proof-of-concept,we found these autologous bio-extractscould effectively promote seed sprouting,seedling germination,and the development of soil-drenched plantsof the same types.Our transmission-electron microscopy characterization of root/shoot pieces shows the presenceof multiple phyto-compounds,including microtubules/actin filaments,cell vacuoles,Golgi stacks/endoplasmicreticulum,cell wall polysaccharide-based cellulose fibers,and organic amorphous nanoparticles and clusters ofcarbon quantum dots in the structure of these extracts.This personalized plant stimulation may induce furthergrowth/defense-related mechanisms,setting new paradigms toward reducing the agrochemical inputs.
文摘2022年12月美国儿科学会发布了新生儿重症监护室(neonatal intensive care unit,NICU)床旁即时超声检查(point-of-care ultrasonography,POCUS)的临床方案。该方案概述了NICU中POCUS的发展和现状,并对NICU顺利开展POCUS的核心要素和实施准则进行了总结。该文对该临床方案的要点进行了解读,并对国内POCUS的开展现状进行了分析,为国内新生儿科开展POCUS提供参考。
文摘目的研究重复经颅磁刺激(Repetitive Transcranial Magnetic Stimulation,rTMS)对缺血性脑卒中后运动功能障碍患者的康复治疗效果及其功能影像学变化。方法纳入缺血性脑卒中患者15例,分为rTMS治疗组8例和传统康复治疗组(Conventional Therapy,CT)7例;rTMS组除接受10天高频rTMS治疗外,其他治疗措施与CT组相同。治疗前和治疗后分别对两组的临床评分进行评估,并进行功能磁共振图像(Functional Magnetic Resonance Imaging,fMRI)采集,比较两组治疗前后及组间临床评分及神经活动低频振幅(Amplitude of Low Frequency Fluctuation,ALFF)的变化情况。结果与治疗前相比,治疗后两组的神经功能明显改善。rTMS组患者的FMA和BI评分改善优于CT组。另外,治疗后两组患者的ALFF比较差异有统计学意义(P<0.05)。其中ALFF值增加的脑区包括:右侧壳核、左侧小脑;ALFF值降低的脑区有:双侧M1区、双侧SMA区、右侧丘脑、右侧小脑。结论高频rTMS可以用于缺血性脑卒中后运动功能障碍患者的康复治疗,且高频rTMS可能通过影响大脑内相关区域的神经活动强度达到康复效果。
