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Random State Approach to Quantum Computation of Electronic-Structure Properties
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作者 Yiran Bai Feng Xiong Xueheng Kuang 《Chinese Physics Letters》 2026年第1期89-104,共16页
Classical computation of electronic properties in large-scale materials remains challenging.Quantum computation has the potential to offer advantages in memory footprint and computational scaling.However,general and v... Classical computation of electronic properties in large-scale materials remains challenging.Quantum computation has the potential to offer advantages in memory footprint and computational scaling.However,general and viable quantum algorithms for simulating large-scale materials are still limited.We propose and implement random-state quantum algorithms to calculate electronic-structure properties of real materials.Using a random state circuit on a small number of qubits,we employ real-time evolution with first-order Trotter decomposition and Hadamard test to obtain electronic density of states,and we develop a modified quantum phase estimation algorithm to calculate real-space local density of states via direct quantum measurements.Furthermore,we validate these algorithms by numerically computing the density of states and spatial distributions of electronic states in graphene,twisted bilayer graphene quasicrystals,and fractal lattices,covering system sizes from hundreds to thousands of atoms.Our results manifest that the random-state quantum algorithms provide a general and qubit-efficient route to scalable simulations of electronic properties in large-scale periodic and aperiodic materials. 展开更多
关键词 periodic materials random state circuit random state quantum algorithms electronic structure properties density states aperiodic materials quantum algorithms quantum computation
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Quantum and Semiclassical Non-Hermitian Dicke Models without Nonreciprocity
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作者 Bin Jiang Yi-Yang Li +2 位作者 Jun-Jie Liu Chen Wang Jian-Hua Jiang 《Chinese Physics Letters》 2025年第12期96-114,共19页
The Dicke model,which describes the collective interaction between an ensemble of atoms and a single-mode photon field,serves as a fundamental framework for studying light-matter interactions and quantum electrodynami... The Dicke model,which describes the collective interaction between an ensemble of atoms and a single-mode photon field,serves as a fundamental framework for studying light-matter interactions and quantum electrodynamic phenomena.In this work,we investigate the manifestation of non-Hermitian effects in a generalized Dicke model,where two dissipative atom ensembles interact with a single-mode photon field.We explore the system in the semiclassical limit as a non-Hermitian Dicke model,revealing rich exceptional points(EPs)and diabolic points.Furthermore,we explore the quantum signature of EPs in the Hilbert space,relying on discrete photon numbers.The transition of photons from antibunching to bunching at steady state is unravelled.Our findings deepen the understanding of non-Hermitian physics in light-matter interaction,which is instructive for the design of advanced photonic devices. 展开更多
关键词 generalized dicke modelwhere light matter interaction dicke model exceptional points diabolic points dissipative atom ensembles non hermitian effects quantum electrodynamic
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Manipulation of High-Fidelity Sidebands under Large Detuning by Floquet Technology:Application to Multi-Mode Cooling
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作者 Xue-Ying Yang Zi-Dong Lin +4 位作者 Shu-Ying Mu Wei Wu Chun-Wang Wu Yi Xie Ping-Xing Chen 《Chinese Physics Letters》 SCIE EI CAS CSCD 2024年第11期53-61,共9页
The Floquet technology,a powerful way to manipulate quantum states,is employed to drive sidebands transition under large detuning.Our results demonstrate that high fidelities over 99%can be achieved through optimizing... The Floquet technology,a powerful way to manipulate quantum states,is employed to drive sidebands transition under large detuning.Our results demonstrate that high fidelities over 99%can be achieved through optimizing suitable modulation frequencies under large detuning.We observe high-fidelity transitions within a high bandwidth by utilizing a single modulation frequency and reveal that this capability is due to the emergence of a flat-band structure in the bandwidth range.The key finding of high-fidelity sideband manipulation under large detuning is experimentally confirmed in nuclear magnetic resonance platform.Finally,we propose a new parallel sideband cooling scheme that enables simultaneous cooling of multiple motional modes.This approach improves the cooling rate compared to conventional schemes with fixed laser frequency and power,and eliminates the need for mode-specific addressing.Our Floquet parallel scheme is applicable to any harmonic oscillator system and is not limited by bandwidth in theory. 展开更多
关键词 tuning BANDS scheme
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New approach to Q-P (P-Q) ordering of quantum mechanical operators and its applications
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作者 胡利云 张浩亮 +1 位作者 贾芳 陶向阳 《Chinese Physics B》 SCIE EI CAS CSCD 2013年第12期70-73,共4页
In this paper, we introduce a new way to obtain the Q-P (P-Q) ordering of quantum mechanical operators, i.e., from the classical correspondence of Q-P (P-Q) ordered operators by replacing q and p with coordinate a... In this paper, we introduce a new way to obtain the Q-P (P-Q) ordering of quantum mechanical operators, i.e., from the classical correspondence of Q-P (P-Q) ordered operators by replacing q and p with coordinate and momentum operators, respectively. Some operator identities are derived concisely. As for its applications, the single (two-) mode squeezed operators and Fresnel operator are examined. It is shown that the classical correspondence of Fresnel operator’s Q-P (P-Q) ordering is just the integration kernel of Fresnel transformation. In addition, a new photo-counting formula is constructed by the Q-P ordering of operators. 展开更多
关键词 Q-P (P-Q) ordering Fresnel operator photo-counting
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Topological Degeneracy Induced Flat Bands in Two-Dimensional Holed Systems
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作者 Yuge Chen Hui Yu +2 位作者 Yun-Peng Huang Zhen-Yu Zheng Jiangping Hu 《Chinese Physics Letters》 2025年第9期305-310,共6页
Systems hosting flat bands offer a powerful platform for exploring strong correlation physics.Theoretically,topological degeneracy arising in systems with non-trivial topological orders on periodic manifolds of non-ze... Systems hosting flat bands offer a powerful platform for exploring strong correlation physics.Theoretically,topological degeneracy arising in systems with non-trivial topological orders on periodic manifolds of non-zero genus can generate ideal flat bands.However,experimental realization of such geometrically engineered systems is very difficult.In this work,we demonstrate that flat planes with strategically patterned hole defects can engineer ideal flat bands.We construct two families of models:singular flat band systems where degeneracy is stabilized by non-contractible loop excitations tied to hole defects and perfectly nested van Hove systems where degeneracy arises from line excitations in momentum space.These models circumvent the need for exotic manifolds while retaining the essential features of topological flat bands.By directly linking defect engineering to degeneracy mechanisms,our results establish a scalable framework for experimentally accessible flat band design. 展开更多
关键词 flat bandswe flat bands strategically patterned hole defects flat planes flat bandshoweverexperimental topological degeneracy geometrically engineered systems strong correlation physicstheoreticallytopological degeneracy
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Exact quantum algorithm for unit commitment optimization based on partially connected quantum neural networks
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作者 Jian Liu Xu Zhou +1 位作者 Zhuojun Zhou Le Luo 《Chinese Physics B》 2025年第10期303-312,共10页
The quantum hybrid algorithm has recently become a very promising and speedy method for solving larger-scale optimization problems in the noisy intermediate-scale quantum(NISQ)era.The unit commitment(UC)problem is a f... The quantum hybrid algorithm has recently become a very promising and speedy method for solving larger-scale optimization problems in the noisy intermediate-scale quantum(NISQ)era.The unit commitment(UC)problem is a fundamental problem in the field of power systems that aims to satisfy the power balance constraint with minimal cost.In this paper,we focus on the implementation of the UC solution using exact quantum algorithms based on the quantum neural network(QNN).This method is tested with a ten-unit system under the power balance constraint.In order to improve computing precision and reduce network complexity,we propose a knowledge-based partially connected quantum neural network(PCQNN).The results show that exact solutions can be obtained by the improved algorithm and that the depth of the quantum circuit can be reduced simultaneously. 展开更多
关键词 quantum computing quantum algorithm unit commitment quantum neural network noisy intermediate-scale quantum era
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Evaluation and Suppression of Vibrational Noise for Cryogenic Surface Electrode Ion Traps
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作者 Qingqing Qin Baoquan Ou +4 位作者 Wei Wu Yi Xie Ting Chen Chunwang Wu Pingxing Chen 《Chinese Physics Letters》 2025年第3期52-62,共11页
Cryogenic ion traps offer substantial advantages over their room-temperature counterparts,particularly in terms of stable ion confinement and cooling.However,this technological advancement has introduced a significant... Cryogenic ion traps offer substantial advantages over their room-temperature counterparts,particularly in terms of stable ion confinement and cooling.However,this technological advancement has introduced a significant challenge,namely the generation of additional vibrational noise.This noise is pronounced during the compression and expansion phases of the Gifford–McMahon cycle refrigerator and stems from the mechanical operation of the cold head.The residual vibrational noise can modulate the Rabi oscillation frequency,thereby compromising the fidelity of the quantum logic gate.In this study,we quantitatively assess the impact of residual vibrational noise and introduce an innovative strategy for its mitigation.This strategy was designed to reduce superimposed potential fluctuations within a cryogenic surface electrode ion trap.The measured residual vibrational noise was used for real-time feedback control.Addressing the inverse determination of the compensating potential for a stable superimposed trapping potential is an inherently ill-posed problem considering known measurement noise results.By applying quadratic programming,we numerically calculated the optimal time series for the compensation potential.An ensemble of these compensation voltages was applied in real time to the static compensation electrodes.Although this method is in the theoretical stage,we believe that it can effectively suppress the translation induced by vibrational noise and foster the creation of a stable superimposed harmonic potential.The deployment of this technique is expected to substantially improve the accuracy of quantum operations,thereby fueling the evolution of quantum technologies. 展开更多
关键词 VIBRATIONAL thereby QUANTUM
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Electronic structure and disorder effect of La_(3)Ni_(2)O_(7)superconductor
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作者 Yuxin Wang Yi Zhang Kun Jiang 《Chinese Physics B》 2025年第4期63-69,共7页
Determining the electronic structure of La_(3)Ni_(2)O_(7)is an essential step towards uncovering its superconducting mechanism.It is widely believed that the bilayer apical oxygens play an important role in the bilaye... Determining the electronic structure of La_(3)Ni_(2)O_(7)is an essential step towards uncovering its superconducting mechanism.It is widely believed that the bilayer apical oxygens play an important role in the bilayer La_(3)Ni_(2)O_(7)electronic structure.Applying the hybrid exchange–correlation functionals,we obtain a more accurate electronic structure of La_(3)Ni_(2)O_(7)at its high-pressure phase,where the bonding dz2 band is below the Fermi level owing to the apical oxygen.The symmetry properties of this electronic structure and its corresponding tight-binding model are further analyzed.We find that the antisymmetric part is highly entangled,leading to a minimal nearly degenerate two-orbital model.Then,the apical oxygen vacancies effect is studied using the dynamical cluster approximation.This disorder effect strongly destroys the antisymmetric b Fermi surface,leading to the possible disappearance of superconductivity. 展开更多
关键词 electronic structure oxygen vacancies disorder dynamical cluster approximation bilayer superconducting nickelate
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Quantum flutter from the nonlinear Luttinger liquid perspective
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作者 Sheng Wang Zhehao Zhang Xi-Wen Guan 《Communications in Theoretical Physics》 2025年第5期153-158,共6页
Quantum flutter is a ubiquitous phenomenon which can be observed from the fast moving impurity injected into a fermionic or bosonic medium of quantum liquid.In this scenario,one usually considers a medium of a fully p... Quantum flutter is a ubiquitous phenomenon which can be observed from the fast moving impurity injected into a fermionic or bosonic medium of quantum liquid.In this scenario,one usually considers a medium of a fully polarized state and injects a spin-flipped impurity as the initial state.When the initial velocity of the impurity is beyond the intrinsic sound velocity of the medium,the impurity momentum dramatically exhibits a long-lived periodic oscillation with the periodicity remaining invariant with respect to the initial velocity.In this paper,we show that such a novel phenomenon can be explained by a linear Luttinger liquid coupled to a deep hole in the Fermi sea.Once the deep hole excitations are involved and the impurity momentum surpasses the Fermi momentum,the propagator thus displays a periodic oscillation after a quick relaxation decay.The oscillation periodicity is solely determined by the energy of the deepest hole excitation.Our result provides deep insights into the dynamical behavior of quantum impurities immersed into one-dimensional quantum liquids. 展开更多
关键词 quantum flutter Yang-Gaudin model Luttinger liquid nonlinear Luttinger liquid
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Efficient characterization of the coupler spectrum via sideband driving in superconducting qubits
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作者 Jianwen Xu Ruonan Guo +8 位作者 Wen Zheng Yu Zhang Jie Zhao Zhiguo Huang Jingwei Wen Runqing Zhang Shaoxiong Li Xinsheng Tan Yang Yu 《Chinese Physics B》 2025年第11期155-160,共6页
Fabrication-friendly superconducting qubits continue to be a leading candidate for scalable quantum computing.Recent developments in tunable couplers have significantly advanced the progress toward practical quantum p... Fabrication-friendly superconducting qubits continue to be a leading candidate for scalable quantum computing.Recent developments in tunable couplers have significantly advanced the progress toward practical quantum processors.However,high-performance quantum control,particularly two-qubit gates,depends on the delicate tuning of the coupler spectrum,as misalignment can lead to undesirable phenomena such as frequency crowding,which may cause errors including state leakage.Here,we propose an efficient method for characterizing the coupler spectrum through sideband drivings,obviating the need for additional components in current quantum processors.We demonstrate this technique experimentally by employing both continuous-wave and pulsed measurement protocols,successfully extracting the coupler spectrum.Furthermore,by utilizing the measured coupler spectrum,we calibrate the frequency dependence of the effective coupling strength between two qubits linked by the coupler.The proposed approach offers significant practical benefits,enabling the efficient characterization of the coupler spectrum in existing quantum architectures,thus paving the way for enhanced quantum control and scalability. 展开更多
关键词 superconducting quantum circuits tunable coupler sideband driving
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Microstructure and Mechanical Properties of AZ31 Mg Alloy Fabricated by Pre-compression and Frustum Shearing Extrusion 被引量:3
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作者 Kun Sheng Li-Wei Lu +2 位作者 Yao Xiang Min Ma Zhong-Chang Wang 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2019年第2期235-244,共10页
The AZ31 Mg alloys were processed by 6% pre-compression and frustum shearing extrusion at various temperatures, and the microstructure, texture and mechanical properties of the resulting alloys are systematically inve... The AZ31 Mg alloys were processed by 6% pre-compression and frustum shearing extrusion at various temperatures, and the microstructure, texture and mechanical properties of the resulting alloys are systematically investigated. The results show that the grain size monotonically increases from 6.4 to 12.6 lm and the texture intensity increases from 6.7 to 9.6with the increase in the extrusion temperature. The combining effect of the pre-twinning and the frustum shearing deformation is found to contribute to the development of the weak basal texture in Mg alloys. The Mg alloy sheet produced at the extrusion temperature of 563 K exhibits excellent mechanical properties. The yield strength, ultimate tensile strength and elongation for the extruded alloys are 189.6 MPa, 288.4 MPa and 24.9%, respectively. Such improved mechanical properties are comparable or even superior to those of the alloys subjected to other deformation techniques, rendering the pre-compression and frustum shearing extrusion a promising way for further tailoring properties of Mg alloys. 展开更多
关键词 AZ31 MAGNESIUM alloy Frustum SHEARING EXTRUSION Microstructure Mechanical property Dynamic RECRYSTALLIZATION
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Countermeasure against blinding attack for single-photon detectors in quantum key distribution 被引量:2
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作者 Lianjun Jiang Dongdong Li +12 位作者 Yuqiang Fang Meisheng Zhao Ming Liu Zhilin Xie Yukang Zhao Yanlin Tang Wei Jiang Houlin Fang Rui Ma Lei Cheng Weifeng Yang Songtao Han Shibiao Tang 《Journal of Semiconductors》 EI CAS CSCD 2024年第4期76-81,共6页
Quantum key distribution(QKD),rooted in quantum mechanics,offers information-theoretic security.However,practi-cal systems open security threats due to imperfections,notably bright-light blinding attacks targeting sin... Quantum key distribution(QKD),rooted in quantum mechanics,offers information-theoretic security.However,practi-cal systems open security threats due to imperfections,notably bright-light blinding attacks targeting single-photon detectors.Here,we propose a concise,robust defense strategy for protecting single-photon detectors in QKD systems against blinding attacks.Our strategy uses a dual approach:detecting the bias current of the avalanche photodiode(APD)to defend against con-tinuous-wave blinding attacks,and monitoring the avalanche amplitude to protect against pulsed blinding attacks.By integrat-ing these two branches,the proposed solution effectively identifies and mitigates a wide range of bright light injection attempts,significantly enhancing the resilience of QKD systems against various bright-light blinding attacks.This method forti-fies the safeguards of quantum communications and offers a crucial contribution to the field of quantum information security. 展开更多
关键词 quantum key distribution single photon detector blinding attack pulsed blinding attack COUNTERMEASURE quan-tum communication
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Classical-Noise-Free Sensing Based on Quantum Correlation Measurement 被引量:1
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作者 Ping Wang Chong Chen Ren-Bao Liu 《Chinese Physics Letters》 SCIE CAS CSCD 2021年第1期3-9,共7页
Quantum sensing,using quantum properties of sensors,can enhance resolution,precision,and sensitivity of imaging,spectroscopy,and detection.An intriguing question is:Can the quantum nature(quantumness)of sensors and ta... Quantum sensing,using quantum properties of sensors,can enhance resolution,precision,and sensitivity of imaging,spectroscopy,and detection.An intriguing question is:Can the quantum nature(quantumness)of sensors and targets be exploited to enable schemes that are not possible for classical probes or classical targets?Here we show that measurement of the quantum correlations of a quantum target indeed allows for sensing schemes that have no classical counterparts.As a concrete example,in the case that the second-order classical correlation of a quantum target could be totally concealed by non-stationary classical noise,the higher-order quantum correlations can single out a quantum target from the classical noise background,regardless of the spectrum,statistics,or intensity of the noise.Hence a classical-noise-free sensing scheme is proposed.This finding suggests that the quantumness of sensors and targets is still to be explored to realize the full potential of quantum sensing.New opportunities include sensitivity beyond classical approaches,non-classical correlations as a new approach to quantum many-body physics,loophole-free tests of the quantum foundation,et cetera. 展开更多
关键词 QUANTUM totally STATIONARY
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Optimal control of quantum systems with SU(1,1)dynamical symmetry 被引量:1
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作者 Wenbin DONG Rebing WU +2 位作者 Jianwu WU Chunwen LI Tzyh-Jong TARN 《Control Theory and Technology》 EI CSCD 2015年第3期211-220,共10页
SU(1,1) dynamical symmetry is of fundamental importance in analyzing unbounded quantum systems in theoretical and applied physics. In this paper, we study the control of generalized coherent states associated with q... SU(1,1) dynamical symmetry is of fundamental importance in analyzing unbounded quantum systems in theoretical and applied physics. In this paper, we study the control of generalized coherent states associated with quantum systems with SU(1,1) dynamical symmetry. Based on a pseudo Riemannian metric on the SU(1,1) group, we obtain necessary conditions for minimizing the field fluence of controls that steer the system to the desired final state. Further analyses show that the candidate optimal control solutions can be classified into normal and abnormal extremals. The abnormal extremals can only be constant functions when the control Hamiltonian is non-parabolic, while the normal extremals can be expressed by Weierstrass elliptic functions according to the parabolicity of the control Hamiltonian. As a special case, the optimal control solution that maximally squeezes a generalized coherent state is a sinusoidal field, which is consistent with what is used in the laboratory. 展开更多
关键词 Quantum control optimal control dynamical symmetry
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Programmable quantum logic gates using teleportation with non-maximally entangled states 被引量:1
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作者 李慧 李春文 姜敏 《Optoelectronics Letters》 EI 2012年第1期63-66,共4页
A scheme is proposed for involving programmable quantum logic gates via teleportation,which is a unique technique in quantum mechanics.In our scheme,considering the inevitable decoherence caused by noisy environment,t... A scheme is proposed for involving programmable quantum logic gates via teleportation,which is a unique technique in quantum mechanics.In our scheme,considering the inevitable decoherence caused by noisy environment,the quantum states are not maximally entangled.We show the implementation of single qubit quantum gates and controlled-NOT(C-NOT) gate,which are universal quantum gates.Hence,any quantum gate can be implemented by using teleportation withnon-maximally entangled states.Furthermore,two schemes in differet connections of universal gates are proposed and compared,and our results show the parallel connection outperforms the cascade connection. 展开更多
关键词 Electric connectors Quantum electronics Quantum entanglement
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Evolution of quantum states via Weyl expansion in dissipative channel
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作者 Li-Yun Hu Zhi-Ming Rao Qing-Qiang Kuang 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第8期160-166,共7页
Based on the Weyl expansion representation of Wigner operator and its invariant property under similar transformation,we derived the relationship between input state and output state after a unitary transformation inc... Based on the Weyl expansion representation of Wigner operator and its invariant property under similar transformation,we derived the relationship between input state and output state after a unitary transformation including Wigner function and density operator.It is shown that they can be related by a transformation matrix corresponding to the unitary evolution.In addition,for any density operator going through a dissipative channel,the evolution formula of the Wigner function is also derived.As applications,we considered further the two-mode squeezed vacuum as inputs,and obtained the resulted Wigner function and density operator within normal ordering form.Our method is clear and concise,and can be easily extended to deal with other problems involved in quantum metrology,steering,and quantum information with continuous variable. 展开更多
关键词 WEYL EXPANSION Wigner operator similar transformation TWO-MODE SQUEEZED state integration within ordered product(IWOP)technique
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Representation of the coherent state for a beam splitter operator and its applications
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作者 Mingxia Zhan Fang Jia +2 位作者 Jiali Huang Huan Zhang Liyun Hu 《Communications in Theoretical Physics》 SCIE CAS CSCD 2022年第3期11-19,共9页
A beam splitter operator is a very important linear device in the field of quantum optics and quantum information.It can not only be used to prepare complete representations of quantum mechanics,entangled state repres... A beam splitter operator is a very important linear device in the field of quantum optics and quantum information.It can not only be used to prepare complete representations of quantum mechanics,entangled state representation,but it can also be used to simulate the dissipative environment of quantum systems.In this paper,by combining the transform relation of the beam splitter operator and the technique of integration within the product of the operator,we present the coherent state representation of the operator and the corresponding normal ordering form.Based on this,we consider the applications of the coherent state representation of the beam splitter operator,such as deriving some operator identities and entangled state representation preparation with continuous-discrete variables.Furthermore,we extend our investigation to two single and two-mode cascaded beam splitter operators,giving the corresponding coherent state representation and its normal ordering form.In addition,the application of a beam splitter to prepare entangled states in quantum teleportation is further investigated,and the fidelity is discussed.The above results provide good theoretical value in the fields of quantum optics and quantum information. 展开更多
关键词 beam splitter operator coherent state representation the technique of integration within product of operator quantum teleportation
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Continuous-variable quantum key distribution based on photon addition operation
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作者 Xiao-Ting Chen Lu-Ping Zhang +2 位作者 Shou-Kang Chang Huan Zhang Li-Yun Hu 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第6期126-132,共7页
It is shown that the non-Gaussian operations can not only be used to prepare the nonclassical states, but also to improve the entanglement degree between Gaussian states. Thus these operations are naturally considered... It is shown that the non-Gaussian operations can not only be used to prepare the nonclassical states, but also to improve the entanglement degree between Gaussian states. Thus these operations are naturally considered to enhance the performance of continuous variable quantum key distribution(CVQKD), in which the non-Gaussian operations are usually placed on the right-side of the entangled source. Here we propose another scheme for further improving the performance of CVQKD with the entangled-based scheme by operating photon-addition operation on the left-side of the entangled source.It is found that the photon-addition operation on the left-side presents both higher success probability and better secure key rate and transmission distance than the photon subtraction on the right-side, although they share the same maximal tolerable noise. In addition, compared to both photon subtraction and photon addition on the right-side, our scheme shows the best performance and the photon addition on the right-side is the worst. 展开更多
关键词 non-Gaussian operations continuous variable quantum key distribution photon-addition operation
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Combined positron emission tomography-guided modified black phosphorus nanosheet-based photothermal therapy and anti programmed cell death protein ligand 1 therapy 被引量:1
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作者 Xiaona Sun Siqi Zhang +6 位作者 Shuo Jiang Jieting Shen Yuxuan Wu Hailong Zhang Ming-Rong Zhang Rui Wang Kuan Hu 《iRADIOLOGY》 2024年第2期103-112,共10页
Background:Patients with cold tumors gain limited benefits from immune checkpoint blockade(ICB)therapy owing to low programmed cell death protein ligand 1(PD-L1)expression and minimal immune cell infiltration.Mild pho... Background:Patients with cold tumors gain limited benefits from immune checkpoint blockade(ICB)therapy owing to low programmed cell death protein ligand 1(PD-L1)expression and minimal immune cell infiltration.Mild photothermal therapy(PTT)using black phosphorus nanosheets(BPNSs)is a promising approach to enhance the efficacy of ICB therapy.However,to ensure that BPNS-based PTT-enhanced ICB therapy is clinically adaptable,a noninvasive,bedside-accessible imaging tool capable of monitoring the status of PD-L1 is imperative.We demonstrated that positron emission tomography(PET)using[64Cu]HKP2202 precisely delineated PD-L1 expression in tumors receiving PTT.Methods:BPNSs were modified with polyethylene glycol to prepare BPNS@PEG,which were then characterized.MC38 cells and tumor allografts were treated with BPNS@PEG followed by 808 nm near-infrared light expo-sure.PET using[64Cu]HKP2202 was performed to monitor PD-L1 expression in vivo.We also evaluated whether the efficacy of ICB therapy improved after delivering BPNS@PEG-based PTT.Results:BPNS@PEG had a well-defined lamellar structure with clear edges and an average size of 150 nm.PET and Western blotting assays indicated that PD-L1 expression was upregulated after BPNS@PEG and NIR-light treatment.Notably,the antitumor effect of anti PD-L1 therapy was enhanced in mice treated with BPNS@PEG-based PTT.Conclusions:BPNS@PEG had the capacity to convert cold tumors into hot tumors to facilitate the efficacy of ICB therapy.Importantly,the comple-mentary diagnostic PET radiotracer targeting PD-L1 allowed real-time moni-toring of PD-L1 expression in the tumor microenvironment to guide ICB administration,holding great potential to achieve efficient and precise tumor immunotherapy. 展开更多
关键词 black phosphorus nanosheets immune checkpoint blockage immune microenvironment PD-L1 positron emission tomography
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A Security Proof of Measurement Device Independent Quantum Key Distribution: From the View of Information Theory 被引量:1
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作者 李芳毅 银振强 +5 位作者 李宏伟 陈巍 王双 温浩 赵义博 韩正甫 《Chinese Physics Letters》 SCIE CAS CSCD 2014年第7期16-19,共4页
Although some ideal quantum key distribution protocols have been proved to be secure, there have been some demonstrations that practical quantum key distribution implementations were hacked due to some real-life imper... Although some ideal quantum key distribution protocols have been proved to be secure, there have been some demonstrations that practical quantum key distribution implementations were hacked due to some real-life imperfections. Among these attacks, detector side channel attacks may be the most serious. Recently, a measurement device independent quantum key distribution protocol [Phys. Rev. Lett. 108 (2012) 130503] was proposed and all detector side channel attacks are removed in this scheme. Here a new security proof based on quantum information theory is given. The eavesdropper's information of the sifted key bits is bounded. Then with this bound, the final secure key bit rate can be obtained. 展开更多
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