Two selective stability-indicating HPLC methods are described for determination of rabeprazole sodium （RZ）-mosapride citrate （MR） and RZ-itopride hydrochloride （IO） mixturcs in the presence of their ICH-stress f...Two selective stability-indicating HPLC methods are described for determination of rabeprazole sodium （RZ）-mosapride citrate （MR） and RZ-itopride hydrochloride （IO） mixturcs in the presence of their ICH-stress formed degradation products. Separations were achieved on X-Bridge CI 8 column using two mobile phases： the first for RZ-MR mixture consisted of acetonitrile： 0.（125 M KH,PO4 solution： TEA （30：69：1 v/v; pH 7.0）; the second for RZ-IO mixture was at ratio of 25：74：1 Iv/v： pH 9.25J. The detection wavelength was 283 nm. The two methods were validated and wdidation acceptance criteria were met in all cases. Peak purity testing using contrast angle theory, relative absorbance and log A versus the wavelengths plots were presented. The % recoveries of the intact drugs were between 99.1% and 102.2% with RSD% values less than 1.6%. Application of the proposed HPLC methods indicated that the methods could be adopted to follow the stability of their formulations.展开更多
Geotechnical properties of sedimentary rocks exposed along upper Egypt-Red Sea road were investigated to evaluate their geotechnical behavior. One of the most important aims of this work was to determine the engineeri...Geotechnical properties of sedimentary rocks exposed along upper Egypt-Red Sea road were investigated to evaluate their geotechnical behavior. One of the most important aims of this work was to determine the engineering problems affected on the road due to the geotechnical behavior of the studied sedimentary rocks and to suggest the suitable solution. Specific weight, unconfined compressive strength, slaking durability and free swelling were measured. The results showed that the studied crystalline limestone, marly limestone and Issawia limestone had higher unconfined compressive strength values ranging from 34,184.00 kN/m2 to 42,602.00 kN/m2 and the studied shale, siltstone and coral reef had lower values ranging from 3,689.00 kN/m2 to 6,933.00 kN/m2. The results showed also that the studied shale, siltstone and mudstone had fast to very fast slaking rate and their slaking amount described as low to medium after Gamble＇s slake durability classification. Replacement and/or chemical stabilization （using lime and/or cement kiln dust） of the expansive sedimentary rocks （shale and mudstone） were recommended to reduce the swelling. Geophysical investigations including shallow seismic, microgravity and GPR （ground penetrating radar） were recommended to scan the sub-grade of the road at El Maaza plateau to determine possible other caves and large voids under the road to avoid its collapse.展开更多
文摘Two selective stability-indicating HPLC methods are described for determination of rabeprazole sodium （RZ）-mosapride citrate （MR） and RZ-itopride hydrochloride （IO） mixturcs in the presence of their ICH-stress formed degradation products. Separations were achieved on X-Bridge CI 8 column using two mobile phases： the first for RZ-MR mixture consisted of acetonitrile： 0.（125 M KH,PO4 solution： TEA （30：69：1 v/v; pH 7.0）; the second for RZ-IO mixture was at ratio of 25：74：1 Iv/v： pH 9.25J. The detection wavelength was 283 nm. The two methods were validated and wdidation acceptance criteria were met in all cases. Peak purity testing using contrast angle theory, relative absorbance and log A versus the wavelengths plots were presented. The % recoveries of the intact drugs were between 99.1% and 102.2% with RSD% values less than 1.6%. Application of the proposed HPLC methods indicated that the methods could be adopted to follow the stability of their formulations.
文摘Geotechnical properties of sedimentary rocks exposed along upper Egypt-Red Sea road were investigated to evaluate their geotechnical behavior. One of the most important aims of this work was to determine the engineering problems affected on the road due to the geotechnical behavior of the studied sedimentary rocks and to suggest the suitable solution. Specific weight, unconfined compressive strength, slaking durability and free swelling were measured. The results showed that the studied crystalline limestone, marly limestone and Issawia limestone had higher unconfined compressive strength values ranging from 34,184.00 kN/m2 to 42,602.00 kN/m2 and the studied shale, siltstone and coral reef had lower values ranging from 3,689.00 kN/m2 to 6,933.00 kN/m2. The results showed also that the studied shale, siltstone and mudstone had fast to very fast slaking rate and their slaking amount described as low to medium after Gamble＇s slake durability classification. Replacement and/or chemical stabilization （using lime and/or cement kiln dust） of the expansive sedimentary rocks （shale and mudstone） were recommended to reduce the swelling. Geophysical investigations including shallow seismic, microgravity and GPR （ground penetrating radar） were recommended to scan the sub-grade of the road at El Maaza plateau to determine possible other caves and large voids under the road to avoid its collapse.
