The Larry Nassar scandal at Michigan State University is the worst and most widespread case of childhood sex abuse in this nation’s history to date,affecting over 150 young girls and women.This article asks:What were...The Larry Nassar scandal at Michigan State University is the worst and most widespread case of childhood sex abuse in this nation’s history to date,affecting over 150 young girls and women.This article asks:What were the structural and ideological mechanisms,policies,and practices that enabled this widespread abuse over a thirty-year period?Louis Althusser’s Marxist theory of Ideological State Apparatuses(and feminist responses to this theory)is useful in explaining how state-making institutions-media outlets,universities,athletic organizations,and family units-are not only produced and reproduced along class lines,but also with respect to gendered power dynamics.By examining the patriarchal nature of ISAs,one can begin to understand how Larry Nassar was for so long shielded from suspicion and criminal prosecution by the institutions that employed him.展开更多
Tellurene,a chiral chain semiconductor with a narrow bandgap and exceptional strain sensitivity,emerges as a pivotal material for tailoring electronic and optoelectronic properties via strain engineering.This study el...Tellurene,a chiral chain semiconductor with a narrow bandgap and exceptional strain sensitivity,emerges as a pivotal material for tailoring electronic and optoelectronic properties via strain engineering.This study elucidates the fundamental mechanisms of ultrafast laser shock imprinting(LSI)in two-dimensional tellurium(Te),establishing a direct relationship between strain field orientation,mold topology,and anisotropic structural evolution.This is the first demonstration of ultrafast LSI on chiral chain Te unveiling orientation-sensitive dislocation networks.By applying controlled strain fields parallel or transverse to Te’s helical chains,we uncover two distinct deformation regimes.Strain aligned parallel to the chain’s direction induces gliding and rotation governed by weak interchain interactions,preserving covalent intrachain bonds and vibrational modes.In contrast,transverse strain drives shear-mediated multimodal deformations—tensile stretching,compression,and bending—resulting in significant lattice distortions and electronic property modulation.We discovered the critical role of mold topology on deformation:sharp-edged gratings generate localized shear forces surpassing those from homogeneous strain fields via smooth CD molds,triggering dislocation tangle formation,lattice reorientation,and inhomogeneous plastic deformation.Asymmetrical strain configurations enable localized structural transformations while retaining single-crystal integrity in adjacent regions—a balance essential for functional device integration.These insights position LSI as a precision tool for nanoscale strain engineering,capable of sculpting 2D material morphologies without compromising crystallinity.By bridging ultrafast mechanics with chiral chain material science,this work advances the design of strain-tunable devices for next-generation electronics and optoelectronics,while establishing a universal framework for manipulating anisotropic 2D systems under extreme strain rates.This work discovered crystallographic orientation-dependent deformation mechanisms in 2D Te,linking parallel strain to chain gliding and transverse strain to shear-driven multimodal distortion.It demonstrates mold geometry as a critical lever for strain localization and dislocation dynamics,with sharp-edged gratings enabling unprecedented control over lattice reorientation.Crucially,the identification of strain field conditions that reconcile severe plastic deformation with single-crystal retention offers a pathway to functional nanostructure fabrication,redefining LSI’s potential in ultrafast strain engineering of chiral chain materials.展开更多
Non-seismically designed(NSD)beam-column joints are susceptible to joint shear failure under seismic loads.Although significant research is available on the seismic behavior of such joints of planar frames,the informa...Non-seismically designed(NSD)beam-column joints are susceptible to joint shear failure under seismic loads.Although significant research is available on the seismic behavior of such joints of planar frames,the information on the seismic behavior of joints of space frames(3D joints)is insufficient.The 3D joints are subjected to bi-directional excitation,which results in an interaction between the shear strength obtained for the joint in the two orthogonal directions separately.The bi-directional seismic behavior of corner reinforced concrete(RC)joints is the focus of this study.First,a detailed finite element(FE)model using the FE software Abaqus,is developed and validated using the test results from the literature.The validated modeling procedure is used to conduct a parametric study to investigate the influence of different parameters such as concrete strength,dimensions of main and transverse beams framing into the joint,presence or absence of a slab,axial load ratio and loading direction on the seismic behavior of joints.By subjecting the models to different combinations of loads on the beams along perpendicular directions,the interaction of the joint shear strength in two orthogonal directions is studied.The comparison of the interaction curves of the joints obtained from the numerical study with a quadratic(circular)interaction curve indicates that in a majority of cases,the quadratic interaction model can represent the strength interaction diagrams of RC beam to column connections with governing joint shear failure reasonably well.展开更多
The wide application of additive-manufactured Ti alloys is impeded by coarse columnar grains along the building direction and thus the severe anisotropy of mechanical properties.To address this issue,a novel multiallo...The wide application of additive-manufactured Ti alloys is impeded by coarse columnar grains along the building direction and thus the severe anisotropy of mechanical properties.To address this issue,a novel multialloying CoCrMoSi strategy has been developed to produce near-equiaxed grains of a modified Ti6Al4V(TC4)alloy for laser-directed energy deposition(LDED)based on computational thermodynamic and experimental approaches.The results show that the microstructure of the TC4alloy consists of large columnar β grains and α/α'laths with a high aspect ratio of 5.73,exhibiting a strong anisotropy of tensile properties.In contrast,the TC4-1.5%CoCrMoSi alloy is characterized by mixed columnarequiaxed β grains and near-equiaxed β grains with increased CoCrMoSi additions to 4.5%.Additionally,the α/α'laths are successively refined with the increase of CoCrMoSi content,showing an aspect ratio of smaller than4.31.However,an excess addition of CoCrMoSi leads to the formation of micro voids.After multi-alloyingCoCrMoSi,the number density of twins increases remarkably with a substantially reduced width,because of the increased lattice distortion and dislocation density together with the reducedβ→αphase transformation temperature.The anisotropy of the tensile properties can be effectively eliminated by adding 3 wt%CoCrMoSi with an exemplary strength-ductility combination,superior to the LDEDed-modified TC4 alloy in the literature reporting the tensile properties along both horizontal(X)and vertical(Z)directions.The underlaying mechanisms for the evolution of the microstructure and the tensile properties induced by multi-alloying CoCrMoSi were discussed in detail.展开更多
A polarization-sensitive and flexible photodetector was fabricated through the precise alignment of perovskite nanowires(NWs)using a brush coating technique.The alignment of the NWs was meticulously examined,consideri...A polarization-sensitive and flexible photodetector was fabricated through the precise alignment of perovskite nanowires(NWs)using a brush coating technique.The alignment of the NWs was meticulously examined,considering various chemical properties of the solvent,such as boiling point,viscosity,and surface tension.Notably,when the NWs were brush-coated with toluene dispersion,the NWs were aligned in higher order than those processed from octane dispersion.The degree of alignment was correlated with the photodetector property.Especially,the well-aligned NW photodetector exhibited a two-fold disparity in current response contingent on the polarization direction.Furthermore,even after enduring 500 bending cycles,the device retained 80%of its photodetector performance.This approach underscores the potential of solution-processed flexible photodetectors for advanced optical applications under dynamic operating conditions.展开更多
Reliability is a persistent challenge in power electronics, with component failures significantly compromising system performance. Capacitors, widely used in power converters for filtering, contribute to approximately...Reliability is a persistent challenge in power electronics, with component failures significantly compromising system performance. Capacitors, widely used in power converters for filtering, contribute to approximately 30% of failures, predominantly due to electrochemical corrosion leading to capacitance degradation and catastrophic breakdowns. This paper presents a novel capacitor-free solid-state power filter(SSPF) for three-phase inverters, offering a transformative approach to mitigate reliability issues associated with conventional inductor-capacitor(LC) and active output filters(AOFs). Unlike AOFs, which depend on compact LC structures, the SSPF eliminates capacitors entirely, circumventing their inherent failure modes. Leveraging advanced solid-state devices and transformer technology, the SSPF achieves superior filtering performance, enhances system reliability, and significantly reduces component count, utilizing half the metal-oxidesemiconductor field effect transistor(MOSFET) switches required by AOFs. This design not only lowers costs but also improves efficiency. Simulation and experimental results demonstrate the SSPF's capability to deliver a sinusoidal output voltage at the fundamental frequency. These attributes position the SSPF as a robust, cost-effective, and innovative solution for modern power electronics applications.展开更多
Pavement condition monitoring and its timely maintenance is necessary to ensure the safety and quality of the roadway infrastructure. The International Roughness Index (IRI) is a commonly used measure to quantify road...Pavement condition monitoring and its timely maintenance is necessary to ensure the safety and quality of the roadway infrastructure. The International Roughness Index (IRI) is a commonly used measure to quantify road surface roughness and is a critical input to asset management. In Indiana, the IRI statistic contributes to roughly half of the pavement quality index computation used for asset management. Most agencies inventory IRI once a year, however, pavement conditions vary much more frequently. The objective of this paper is to develop a framework using crowdsourced connected vehicle data to identify and detect temporal changes in IRI. Over 3 billion connected vehicle records in Indiana were analyzed across 30 months between 2022 and 2024 to understand the spatiotemporal variations in roughness. Annual comparisons across all major interstates in Indiana showed the miles of interstates classified as “Good” decreased from 1896 to 1661 miles between 2022 and 2024. The miles of interstate classified as “Needs Maintenance” increased from 82 to 120 miles. A detailed case study showing monthly and daily changes of estimated IRI on I-65 are presented along with supporting dashcam images. Although the crowdsourced IRI estimates are not as robust as traditional specialized pavement profilers, they can be obtained on a monthly, weekly, or even daily basis. The paper concludes by suggesting a combination of frequent crowdsourced IRI and commercially available dashcam imagery of roadway can provide an agile and responsive mechanism for agencies to implement pavement asset management programs that can complement existing annual programs.展开更多
The objective of this paper is to present a robust safety-critical control system based on the active disturbance rejection control approach, designed to guarantee safety even in the presence of model inaccuracies, un...The objective of this paper is to present a robust safety-critical control system based on the active disturbance rejection control approach, designed to guarantee safety even in the presence of model inaccuracies, unknown dynamics, and external disturbances. The proposed method combines control barrier functions and control Lyapunov functions with a nonlinear extended state observer to produce a robust and safe control strategy for dynamic systems subject to uncertainties and disturbances. This control strategy employs an optimization-based control, supported by the disturbance estimation from a nonlinear extended state observer. Using a quadratic programming algorithm, the controller computes an optimal, stable, and safe control action at each sampling instant. The effectiveness of the proposed approach is demonstrated through numerical simulations of a safety-critical interconnected adaptive cruise control system.展开更多
Background Black soldier fly larvae meal(BSFLM)stands out as a promising nutritional resource due to its rich bioactive substances and favorable protein profile.Nonetheless,its potential to mitigate coccidia infection...Background Black soldier fly larvae meal(BSFLM)stands out as a promising nutritional resource due to its rich bioactive substances and favorable protein profile.Nonetheless,its potential to mitigate coccidia infection in broilers remains uncertain.This study aimed to evaluate the impact of partially defatted BSFLM(pBSFLM)on growth performance,nutrient utilization,and intestinal health,focusing on morphology,immunology,and cecal fermentation in coccidia-infected broilers.Methods Over the initial 13 d,480 newly-hatched Cobb 500 male birds were allocated to three diets with increasing pBSFLM concentrations(0,60,or 120 g/kg).At d 13 post hatching,chicks within each dietary group were further allotted to non-challenge or challenge subsets,generating six treatments in a 3×2 factorial arrangement.Challenged birds were orally administered oocysts of E.maxima,E.acervulina,and E.tenella(25,000:125,000:25,000).Results During the infection phase(d 13 to 19),linear interactions between Eimeria and pBSFLM were observed in gain to feed ratio(G:F)(P<0.05)and cecal interferon-γ(IFN-γ,P<0.05),with a tendency in cecal acetate concentration(P=0.06).A quadratic interaction was observed in crypt depth(CD,P<0.05).Incremental pBSFLM inclusion negatively affected G:F,CD,IFN-γ,and acetate productions in the ceca under coccidia challenge.Conversely in nonchallenged birds,the impact of pBSFLM varied from neutral(e.g.G:F)to potentially advantageous(e.g.acetate).Challenged birds exhibited decreased(P<0.01)BW,BW gain,feed intake(FI),and the apparent ileal digestibility and total tract nutrient utilization of DM,gross energy,and nitrogen(N).Eimeria challenge reduced(P<0.01)serum carotenoid concentrations,decreased the villus height to crypt depth ratio(VH:CD,P<0.01),and increased concentrations of branched-chain fatty acids,specifically isobutyrate(P=0.059)and isovalerate(P<0.05)in the cecum.Dietary pBSFLM addition linearly reduced(P<0.05)BW,FI,and N utilization.Tendencies(P<0.06)were observed where pBSFLM linearly decreased VH:CD and reduced goblet cell density.Conclusions Increasing pBSFLM supplementation,particularly at 12%,adversely affected growth,ileal morphology,cecal acetate production,and downregulated key cytokine expression in response to coccidia infection.展开更多
The addition of nanoparticles serves as an effective reinforcement strategy for polymeric coatings,utilizing their unique characteristics as well as extraordinary mechanical,thermal,and electrical properties.The excep...The addition of nanoparticles serves as an effective reinforcement strategy for polymeric coatings,utilizing their unique characteristics as well as extraordinary mechanical,thermal,and electrical properties.The exceptionally high surface-to-volume ratio of nanoparticles imparts remarkable reinforcing potentials,yet it simultaneously gives rise to a prevalent tendency for nanoparticles to agglomerate into clusters within nanocomposites.The agglomeration behavior of the nanoparticles is predominantly influenced by their distinct microstructures and varied weight concentrations.This study investigated the synergistic effects of nanoparticle geometric shape and weight concentration on the dispersion characteristics of nanoparticles and the physical-mechanical performances of nano-reinforced epoxy coatings.Three carbon-based nanoparticles,nanodiamonds(NDs),carbon nanotubes(CNTs),and graphenes(GNPs),were incorporated into epoxy coatings at three weight concentrations(0.5%,1.0%,and 2.0%).The experimental findings reveal that epoxy coatings reinforced with NDs demonstrated the most homogenous dispersion characteristics,lowest viscosity,and reduced porosity among all the nanoparticles,which could be attributed to the spherical geometry shape.Due to the superior physical properties,ND-reinforced nanocomposites displayed the highest abrasion resistance and tensile properties.Specifically,the 1.0wt%ND-reinforced nanocomposites exhibited 60%,52%,and 97%improvements in mass lost,tensile strength,and failure strain,respectively,compared to pure epoxy.Furthermore,the representative volume element(RVE)modeling was employed to validate the experimental results,while highlighting the critical role of nanoparticle agglomeration,orientation,and the presence of voids on the mechanical properties of the nanocomposites.Nano-reinforced epoxy coatings with enhanced mechanical properties are well-suited for application in protective coatings for pipelines,industrial equipment,and automotive parts,where high wear resistance is essential.展开更多
A coalescence model was employed to form deuterons(d),tritons(t),and helium-3(^(3)He)nuclei from a uniformly-distributed volume of protons(p)and neutrons(n).We studied the ratio N_(t)N_(p)/N_(d)^(2)of light nuclei yie...A coalescence model was employed to form deuterons(d),tritons(t),and helium-3(^(3)He)nuclei from a uniformly-distributed volume of protons(p)and neutrons(n).We studied the ratio N_(t)N_(p)/N_(d)^(2)of light nuclei yields as a function of the neutron density fluctuations.We investigated the effect of finite transverse momentum(p_(T))acceptance on the ratio,in particular,the“extrapolation factor”(f)for the ratio as a function of the p_(T)spectral shape and the magnitude of neutron density fluctuations.The nature of f was found to be monotonic in p_(T)spectra“temperature”parameter and neutron density fluctuation magnitude;variations in the latter are relatively small.We also examined f in realistic simulations using the kinematic distributions of protons measured from the heavy-ion collision data.The nature of f was found to be smooth and monotonic as a function of the beam energy.Therefore,we conclude that extrapolation from limited p_(T)ranges does not create,enhance,or reduce the local peak of the N_(t)N_(p)/N_(d)^(2)ratio in the beam energy.Our study provides a necessary benchmark for light nuclei ratios as a probe for nucleon density fluctuations,an important observation in the search for the critical point of nuclear matter.展开更多
Lipid nanoparticles(LNPs)have emerged as versatile carriers for the delivery of genetic medicines and small-molecule drugs,offering desired benefits for therapeutic applications.Optimization of the treatment efficacy ...Lipid nanoparticles(LNPs)have emerged as versatile carriers for the delivery of genetic medicines and small-molecule drugs,offering desired benefits for therapeutic applications.Optimization of the treatment efficacy of nanocarriers necessitates a thorough understanding of the connection between pharmacokinetics and physicochemical properties.This review consolidates scientific efforts to elucidate how LNP’s physicochemical attributes influence their in vivo fate,emphasizing particle size and shape,surface electric potential and ligand-binding chemistry.By examining the interplay between LNPs and biological barriers across various administration routes,this review provides insights into tailoring LNP properties for optimal delivery and reduced off-target effects.Recommendations for future research are provided to advance the study of LNP in vivo behaviors and offer a practical framework for optimizing in vivo performance through product design parameters.展开更多
The liver is a crucial gland and the second-largest organ in the human body and also essential in digestion,metabolism,detoxification,and immunity.Liver diseases result from factors such as viral infections,obesity,al...The liver is a crucial gland and the second-largest organ in the human body and also essential in digestion,metabolism,detoxification,and immunity.Liver diseases result from factors such as viral infections,obesity,alcohol consumption,injuries,or genetic predispositions.Pose significant health risks and demand timely diagnosis and treatment to enhance survival rates.Traditionally,diagnosing liver diseases relied heavily on clinical expertise,often leading to subjective,challenging,and time-intensive processes.However,early detection is essential for effective intervention,and advancements in machine learning(ML)have demonstrated remarkable success in predicting various conditions,including Chronic Obstructive Pulmonary Disease(COPD),hypertension,and diabetes.This study proposed a novel XGBoost-liver predictor by integrating distinct feature methodologies,including Ranking and Statistical Projection-based strategies to detect early signs of liver disease.The Fisher score method is applied to perform global interpretation analysis,helping to select optimal features by assessing their contributions to the overall model.The performance of the proposed model has been extensively evaluated through k-fold cross-validation tests.Firstly,the performance of the proposed model is evaluated using individual and hybrid features.Secondly,the XGBoost-Liver model performance is compared to that of commonly used classifier algorithms.Thirdly,its performance is compared with the existing state-of-the-art computational models.The experimental results show that the proposed model performed better than the existing predictors,reaching an average accuracy rate of 92.07%.This paper demonstrates the potential of machine learning to improve liver disease prediction,enhance diagnostic accuracy,and enable timely medical interventions for better patient outcomes.展开更多
Background Body weight is an important indicator of the overall health and production efficiency in broiler chickens.In broiler houses,body weight of chicks is variable despite the same genetics,hatching and feeding p...Background Body weight is an important indicator of the overall health and production efficiency in broiler chickens.In broiler houses,body weight of chicks is variable despite the same genetics,hatching and feeding practices within a production system.The objective of this study was to investigate the intestinal microbiota and bile salt hydrolase(BSH)activity in slow and fast growing broiler chickens,which belonged to the 10th and 90th percentile body weight groups,respectively.Methods A total of 300 Ross 308 broiler chickens(100 per cohort from three independent cohorts)were selected and mucosal samples from the jejunum,ileum,and cecum were collected at day of arrival,11 and 25(n=450).Then,bacterial counts,16S rRNA amplicon sequencing,species specific real-time qPCR,as well as BSH activity were analyzed.Results Results of bacterial counts showed no significant difference between slow and fast growing cohorts(P>0.05),but they tended to be higher in the slow growing chickens in all measured bacterial groups in cecum.The 16S rRNA amplicon sequencing revealed higher relative abundance of E.coli-Shigella(71.3%−79.8%)at day of arrival,while the most abundant microorganisms at d 25 was Candidatus Arthromitus(slow:44.5%;fast:27.4%)in small intestine.qPCR results indicated significant differences in bacterial populations between the slow and fast growing chickens,especially higher total bacteria,Enterococcus,and Clostridium cluster I in the slow growing chickens at d 25.BSH activity was higher in the slow growing chickens than the fast growing chickens[slow:0.476ΔOD/protein(μg/mL);fast:0.258ΔOD/protein(μg/mL);P<0.0001],and correlation analysis highlighted associations between BSH activity,body weight,feed intake,body weight gain,and bacterial counts.Conclusions We postulate that high total bacteria and Enterococcus abundance are associated with high BSH activity,impacting low feed intake and body weight gain,ultimately resulting in separation into slow and fast growing birds.The findings of this study contribute to understanding the relationship between gut microbiota,BSH activity,and host physiology in broiler chickens,with potential implications for poultry production.展开更多
Due to the rapid development and potential applications of iron(Ⅲ)-alginate(Fe-Alg)microgels in biomedical as well as environmental engineering,this study explores the preparation and characterization of spherical Fe...Due to the rapid development and potential applications of iron(Ⅲ)-alginate(Fe-Alg)microgels in biomedical as well as environmental engineering,this study explores the preparation and characterization of spherical Fe-Alg microgels using droplet microfluidics combined with an external ionic crosslinking method.This study focused on the role of Fe^(3+)and examined its effects on the physical/chemical properties of microgels under different ionic conditions and reduced or oxidized states.The pH-dependent release behavior of Fe^(3+)from these microgels demonstrates their potential biomedical and environmental applications.Furthermore,the microgels can exhibit magnetism simply by utilizing in situ oxidation,which can be further used for targeted drug delivery and magnetic separation technologies.展开更多
Permafrost degradation under climate warming plays a crucial role in hydrological and ecological processes,including the regional water cycle and terrestrial carbon balance.The Tibetan Plateau(TP),which contains the l...Permafrost degradation under climate warming plays a crucial role in hydrological and ecological processes,including the regional water cycle and terrestrial carbon balance.The Tibetan Plateau(TP),which contains the largest expanse of high-altitude permafrost globally,remains understudied in terms of how permafrost degradation affects surface water resources and regional carbon dynamics.Using permafrost simulation models and quantitative analysis,we assess the spatiotemporal impacts of permafrost degradation on surface water resources and carbon dynamics.In the inner endorheic regions of the TP,ground ice meltwater contributed 12.6%of the total lake volume increase from 2000 to 2020,accelerating lake expansion and affecting nearby infrastructure and ecosystems.Cryospheric meltwater accounted for 4.6%of total runoff in the source areas of the Yangtze,Yellow,Lancang,Yarlung Zangbo,and Nujiang Rivers in 2002-2018.This cryospheric meltwater contribution is projected to peak in the 2030s-2040s,followed by a decline,with potentially profound implications for downstream water availability.From 2000 to 2020,carbon sequestration of alpine grassland in permafrost regions is 1.05-1.29 Tg C a^(-1)in 2000-2020.This estimate is underestimated by approximately 35.5%to 48.1%without considering the impact of permafrost degradation.Top-down thawing of permafrost from 2002 to 2050 is projected to release 129.39±21.02 Tg C a^(-1)of thawed soil organic carbon(SOC),with 20.82±3.06 Tg C a^(-1)decomposed annually.Additionally,permafrost collapse and thermokarst lake are estimated to reduce ecosystem carbon sinks by 0.41(0.29-0.52)Tg C a^(-1)in 2020.展开更多
This study investigates the electrochemical behavior of molybdenum disulfide(MoS_(2))as an anode in Li-ion batteries,focusing on the extra capacity phenomenon.Employing advanced characterization methods such as in sit...This study investigates the electrochemical behavior of molybdenum disulfide(MoS_(2))as an anode in Li-ion batteries,focusing on the extra capacity phenomenon.Employing advanced characterization methods such as in situ and ex situ X-ray diffraction,Raman spectroscopy,X-ray photoelectron spectroscopy,and transmission electron microscopy,the research unravels the complex structural and chemical evolution of MoS_(2) throughout its cycling.A key discovery is the identification of a unique Li intercalation mechanism in MoS_(2),leading to the formation of reversible Li_(2)MoS_(2) phases that contribute to the extra capacity of the MoS_(2) electrode.Density function theory calculations suggest the potential for overlithiation in MoS_(2),predicting Li5MoS_(2) as the most energetically favorable phase within the lithiation–delithiation process.Additionally,the formation of a Li-rich phase on the surface of Li_(4)MoS_(2) is considered energetically advantageous.After the first discharge,the battery system engages in two main reactions.One involves operation as a Li-sulfur battery within the carbonate electrolyte,and the other is the reversible intercalation and deintercalation of Li in Li_(2)MoS_(2).The latter reaction contributes to the extra capacity of the battery.The incorporation of reduced graphene oxide as a conductive additive in MoS_(2) electrodes notably improves their rate capability and cycling stability.展开更多
Interfacial modular assemblies of versatile polyphenols have attracted widespread interest in surface and materials engineering.In this study,natural polyphenol(tannic acid,TA)and nobiletin(NOB)can directly form binar...Interfacial modular assemblies of versatile polyphenols have attracted widespread interest in surface and materials engineering.In this study,natural polyphenol(tannic acid,TA)and nobiletin(NOB)can directly form binary carrier-free spherical nanoparticles(NT NPs)through synergistically driven by a variety of interactions(such as hydrogen bonding,oxidative reactions,etc.).The synthesis involves polyphenolic deposition on hydrophobic NOB nanoaggregates,followed by in situ oxidative self-polymerization.Interestingly,the assembled NT NPs exhibit controllable and dynamic changes in particle size during the initial stage.Ultimately,uniform and spherical NT NPs appear stable,with high loading capability,enabling incorporated NOB to preserve their function.Furthermore,in vitro evaluations demonstrate that the rational combination of polyphenol module and NOB can induce apoptosis and inhibit tumor metastasis for both lung cancer H1299 and human fibrosarcoma HT1080 cell lines.Notably,the optimized NT48 NPs were then verified in vivo experiments to achieve a promising synergistic anti-tumor efficacy.These findings not only provide new opportunities for the streamlined and sensible engineering of future polyphenol-based biomaterials,but also open up new prospects for the design of smallmolecule nature phytochemicals.展开更多
文摘The Larry Nassar scandal at Michigan State University is the worst and most widespread case of childhood sex abuse in this nation’s history to date,affecting over 150 young girls and women.This article asks:What were the structural and ideological mechanisms,policies,and practices that enabled this widespread abuse over a thirty-year period?Louis Althusser’s Marxist theory of Ideological State Apparatuses(and feminist responses to this theory)is useful in explaining how state-making institutions-media outlets,universities,athletic organizations,and family units-are not only produced and reproduced along class lines,but also with respect to gendered power dynamics.By examining the patriarchal nature of ISAs,one can begin to understand how Larry Nassar was for so long shielded from suspicion and criminal prosecution by the institutions that employed him.
基金financial support from NSF ExpandQISE program.The synthesis of tellurene was supported by NSF under grant no.CMMI-2046936supports from Purdue Research Foundation.
文摘Tellurene,a chiral chain semiconductor with a narrow bandgap and exceptional strain sensitivity,emerges as a pivotal material for tailoring electronic and optoelectronic properties via strain engineering.This study elucidates the fundamental mechanisms of ultrafast laser shock imprinting(LSI)in two-dimensional tellurium(Te),establishing a direct relationship between strain field orientation,mold topology,and anisotropic structural evolution.This is the first demonstration of ultrafast LSI on chiral chain Te unveiling orientation-sensitive dislocation networks.By applying controlled strain fields parallel or transverse to Te’s helical chains,we uncover two distinct deformation regimes.Strain aligned parallel to the chain’s direction induces gliding and rotation governed by weak interchain interactions,preserving covalent intrachain bonds and vibrational modes.In contrast,transverse strain drives shear-mediated multimodal deformations—tensile stretching,compression,and bending—resulting in significant lattice distortions and electronic property modulation.We discovered the critical role of mold topology on deformation:sharp-edged gratings generate localized shear forces surpassing those from homogeneous strain fields via smooth CD molds,triggering dislocation tangle formation,lattice reorientation,and inhomogeneous plastic deformation.Asymmetrical strain configurations enable localized structural transformations while retaining single-crystal integrity in adjacent regions—a balance essential for functional device integration.These insights position LSI as a precision tool for nanoscale strain engineering,capable of sculpting 2D material morphologies without compromising crystallinity.By bridging ultrafast mechanics with chiral chain material science,this work advances the design of strain-tunable devices for next-generation electronics and optoelectronics,while establishing a universal framework for manipulating anisotropic 2D systems under extreme strain rates.This work discovered crystallographic orientation-dependent deformation mechanisms in 2D Te,linking parallel strain to chain gliding and transverse strain to shear-driven multimodal distortion.It demonstrates mold geometry as a critical lever for strain localization and dislocation dynamics,with sharp-edged gratings enabling unprecedented control over lattice reorientation.Crucially,the identification of strain field conditions that reconcile severe plastic deformation with single-crystal retention offers a pathway to functional nanostructure fabrication,redefining LSI’s potential in ultrafast strain engineering of chiral chain materials.
文摘Non-seismically designed(NSD)beam-column joints are susceptible to joint shear failure under seismic loads.Although significant research is available on the seismic behavior of such joints of planar frames,the information on the seismic behavior of joints of space frames(3D joints)is insufficient.The 3D joints are subjected to bi-directional excitation,which results in an interaction between the shear strength obtained for the joint in the two orthogonal directions separately.The bi-directional seismic behavior of corner reinforced concrete(RC)joints is the focus of this study.First,a detailed finite element(FE)model using the FE software Abaqus,is developed and validated using the test results from the literature.The validated modeling procedure is used to conduct a parametric study to investigate the influence of different parameters such as concrete strength,dimensions of main and transverse beams framing into the joint,presence or absence of a slab,axial load ratio and loading direction on the seismic behavior of joints.By subjecting the models to different combinations of loads on the beams along perpendicular directions,the interaction of the joint shear strength in two orthogonal directions is studied.The comparison of the interaction curves of the joints obtained from the numerical study with a quadratic(circular)interaction curve indicates that in a majority of cases,the quadratic interaction model can represent the strength interaction diagrams of RC beam to column connections with governing joint shear failure reasonably well.
基金financially supported by the National Natural Science Foundation of China(No.52375341)Hunan Provincial Natural Science Foundation(No.2022JJ30494)
文摘The wide application of additive-manufactured Ti alloys is impeded by coarse columnar grains along the building direction and thus the severe anisotropy of mechanical properties.To address this issue,a novel multialloying CoCrMoSi strategy has been developed to produce near-equiaxed grains of a modified Ti6Al4V(TC4)alloy for laser-directed energy deposition(LDED)based on computational thermodynamic and experimental approaches.The results show that the microstructure of the TC4alloy consists of large columnar β grains and α/α'laths with a high aspect ratio of 5.73,exhibiting a strong anisotropy of tensile properties.In contrast,the TC4-1.5%CoCrMoSi alloy is characterized by mixed columnarequiaxed β grains and near-equiaxed β grains with increased CoCrMoSi additions to 4.5%.Additionally,the α/α'laths are successively refined with the increase of CoCrMoSi content,showing an aspect ratio of smaller than4.31.However,an excess addition of CoCrMoSi leads to the formation of micro voids.After multi-alloyingCoCrMoSi,the number density of twins increases remarkably with a substantially reduced width,because of the increased lattice distortion and dislocation density together with the reducedβ→αphase transformation temperature.The anisotropy of the tensile properties can be effectively eliminated by adding 3 wt%CoCrMoSi with an exemplary strength-ductility combination,superior to the LDEDed-modified TC4 alloy in the literature reporting the tensile properties along both horizontal(X)and vertical(Z)directions.The underlaying mechanisms for the evolution of the microstructure and the tensile properties induced by multi-alloying CoCrMoSi were discussed in detail.
基金supported by a Commercialization Promotion Agency for R&D Outcomes(COMPA)Grant funded by the Korean Government(Ministry of Science and ICT)(No.RS-2023-00304743)the National Research Foundation of Korea(NRF)Grant funded by the Korean Government(MSIT)(No.2022M3J7A1066428)"Regional Innovation Strategy(RIS)"through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(MOE)(No.2023RIS-008).
文摘A polarization-sensitive and flexible photodetector was fabricated through the precise alignment of perovskite nanowires(NWs)using a brush coating technique.The alignment of the NWs was meticulously examined,considering various chemical properties of the solvent,such as boiling point,viscosity,and surface tension.Notably,when the NWs were brush-coated with toluene dispersion,the NWs were aligned in higher order than those processed from octane dispersion.The degree of alignment was correlated with the photodetector property.Especially,the well-aligned NW photodetector exhibited a two-fold disparity in current response contingent on the polarization direction.Furthermore,even after enduring 500 bending cycles,the device retained 80%of its photodetector performance.This approach underscores the potential of solution-processed flexible photodetectors for advanced optical applications under dynamic operating conditions.
基金curruntly supported by the Purdue University Office of Technology Commercialization under Track Code (PRF 71167-01)。
文摘Reliability is a persistent challenge in power electronics, with component failures significantly compromising system performance. Capacitors, widely used in power converters for filtering, contribute to approximately 30% of failures, predominantly due to electrochemical corrosion leading to capacitance degradation and catastrophic breakdowns. This paper presents a novel capacitor-free solid-state power filter(SSPF) for three-phase inverters, offering a transformative approach to mitigate reliability issues associated with conventional inductor-capacitor(LC) and active output filters(AOFs). Unlike AOFs, which depend on compact LC structures, the SSPF eliminates capacitors entirely, circumventing their inherent failure modes. Leveraging advanced solid-state devices and transformer technology, the SSPF achieves superior filtering performance, enhances system reliability, and significantly reduces component count, utilizing half the metal-oxidesemiconductor field effect transistor(MOSFET) switches required by AOFs. This design not only lowers costs but also improves efficiency. Simulation and experimental results demonstrate the SSPF's capability to deliver a sinusoidal output voltage at the fundamental frequency. These attributes position the SSPF as a robust, cost-effective, and innovative solution for modern power electronics applications.
文摘Pavement condition monitoring and its timely maintenance is necessary to ensure the safety and quality of the roadway infrastructure. The International Roughness Index (IRI) is a commonly used measure to quantify road surface roughness and is a critical input to asset management. In Indiana, the IRI statistic contributes to roughly half of the pavement quality index computation used for asset management. Most agencies inventory IRI once a year, however, pavement conditions vary much more frequently. The objective of this paper is to develop a framework using crowdsourced connected vehicle data to identify and detect temporal changes in IRI. Over 3 billion connected vehicle records in Indiana were analyzed across 30 months between 2022 and 2024 to understand the spatiotemporal variations in roughness. Annual comparisons across all major interstates in Indiana showed the miles of interstates classified as “Good” decreased from 1896 to 1661 miles between 2022 and 2024. The miles of interstate classified as “Needs Maintenance” increased from 82 to 120 miles. A detailed case study showing monthly and daily changes of estimated IRI on I-65 are presented along with supporting dashcam images. Although the crowdsourced IRI estimates are not as robust as traditional specialized pavement profilers, they can be obtained on a monthly, weekly, or even daily basis. The paper concludes by suggesting a combination of frequent crowdsourced IRI and commercially available dashcam imagery of roadway can provide an agile and responsive mechanism for agencies to implement pavement asset management programs that can complement existing annual programs.
基金supported by the Fondo para el Primer Proyecto of the Comitépara el Desarrollo de la Investigación(CODI)at the Universidad de Antioquia(Grant Number PRV2024-78509)。
文摘The objective of this paper is to present a robust safety-critical control system based on the active disturbance rejection control approach, designed to guarantee safety even in the presence of model inaccuracies, unknown dynamics, and external disturbances. The proposed method combines control barrier functions and control Lyapunov functions with a nonlinear extended state observer to produce a robust and safe control strategy for dynamic systems subject to uncertainties and disturbances. This control strategy employs an optimization-based control, supported by the disturbance estimation from a nonlinear extended state observer. Using a quadratic programming algorithm, the controller computes an optimal, stable, and safe control action at each sampling instant. The effectiveness of the proposed approach is demonstrated through numerical simulations of a safety-critical interconnected adaptive cruise control system.
文摘Background Black soldier fly larvae meal(BSFLM)stands out as a promising nutritional resource due to its rich bioactive substances and favorable protein profile.Nonetheless,its potential to mitigate coccidia infection in broilers remains uncertain.This study aimed to evaluate the impact of partially defatted BSFLM(pBSFLM)on growth performance,nutrient utilization,and intestinal health,focusing on morphology,immunology,and cecal fermentation in coccidia-infected broilers.Methods Over the initial 13 d,480 newly-hatched Cobb 500 male birds were allocated to three diets with increasing pBSFLM concentrations(0,60,or 120 g/kg).At d 13 post hatching,chicks within each dietary group were further allotted to non-challenge or challenge subsets,generating six treatments in a 3×2 factorial arrangement.Challenged birds were orally administered oocysts of E.maxima,E.acervulina,and E.tenella(25,000:125,000:25,000).Results During the infection phase(d 13 to 19),linear interactions between Eimeria and pBSFLM were observed in gain to feed ratio(G:F)(P<0.05)and cecal interferon-γ(IFN-γ,P<0.05),with a tendency in cecal acetate concentration(P=0.06).A quadratic interaction was observed in crypt depth(CD,P<0.05).Incremental pBSFLM inclusion negatively affected G:F,CD,IFN-γ,and acetate productions in the ceca under coccidia challenge.Conversely in nonchallenged birds,the impact of pBSFLM varied from neutral(e.g.G:F)to potentially advantageous(e.g.acetate).Challenged birds exhibited decreased(P<0.01)BW,BW gain,feed intake(FI),and the apparent ileal digestibility and total tract nutrient utilization of DM,gross energy,and nitrogen(N).Eimeria challenge reduced(P<0.01)serum carotenoid concentrations,decreased the villus height to crypt depth ratio(VH:CD,P<0.01),and increased concentrations of branched-chain fatty acids,specifically isobutyrate(P=0.059)and isovalerate(P<0.05)in the cecum.Dietary pBSFLM addition linearly reduced(P<0.05)BW,FI,and N utilization.Tendencies(P<0.06)were observed where pBSFLM linearly decreased VH:CD and reduced goblet cell density.Conclusions Increasing pBSFLM supplementation,particularly at 12%,adversely affected growth,ileal morphology,cecal acetate production,and downregulated key cytokine expression in response to coccidia infection.
基金supported by the National Science Foundation(NSF)(No.CMMI-1750316)Pipeline and Hazardous Materials Safety Administration(PHMSA)of U.S.Department of Transportation(No.693JK31950008CAAP).
文摘The addition of nanoparticles serves as an effective reinforcement strategy for polymeric coatings,utilizing their unique characteristics as well as extraordinary mechanical,thermal,and electrical properties.The exceptionally high surface-to-volume ratio of nanoparticles imparts remarkable reinforcing potentials,yet it simultaneously gives rise to a prevalent tendency for nanoparticles to agglomerate into clusters within nanocomposites.The agglomeration behavior of the nanoparticles is predominantly influenced by their distinct microstructures and varied weight concentrations.This study investigated the synergistic effects of nanoparticle geometric shape and weight concentration on the dispersion characteristics of nanoparticles and the physical-mechanical performances of nano-reinforced epoxy coatings.Three carbon-based nanoparticles,nanodiamonds(NDs),carbon nanotubes(CNTs),and graphenes(GNPs),were incorporated into epoxy coatings at three weight concentrations(0.5%,1.0%,and 2.0%).The experimental findings reveal that epoxy coatings reinforced with NDs demonstrated the most homogenous dispersion characteristics,lowest viscosity,and reduced porosity among all the nanoparticles,which could be attributed to the spherical geometry shape.Due to the superior physical properties,ND-reinforced nanocomposites displayed the highest abrasion resistance and tensile properties.Specifically,the 1.0wt%ND-reinforced nanocomposites exhibited 60%,52%,and 97%improvements in mass lost,tensile strength,and failure strain,respectively,compared to pure epoxy.Furthermore,the representative volume element(RVE)modeling was employed to validate the experimental results,while highlighting the critical role of nanoparticle agglomeration,orientation,and the presence of voids on the mechanical properties of the nanocomposites.Nano-reinforced epoxy coatings with enhanced mechanical properties are well-suited for application in protective coatings for pipelines,industrial equipment,and automotive parts,where high wear resistance is essential.
基金supported in part by the U.S.Department of Energy(No.DE-SC0012910)National Nature Science Foundation of China(Nos.12035006 and 12075085)the Ministry of Science and Technology of China(No.2020YFE020200)。
文摘A coalescence model was employed to form deuterons(d),tritons(t),and helium-3(^(3)He)nuclei from a uniformly-distributed volume of protons(p)and neutrons(n).We studied the ratio N_(t)N_(p)/N_(d)^(2)of light nuclei yields as a function of the neutron density fluctuations.We investigated the effect of finite transverse momentum(p_(T))acceptance on the ratio,in particular,the“extrapolation factor”(f)for the ratio as a function of the p_(T)spectral shape and the magnitude of neutron density fluctuations.The nature of f was found to be monotonic in p_(T)spectra“temperature”parameter and neutron density fluctuation magnitude;variations in the latter are relatively small.We also examined f in realistic simulations using the kinematic distributions of protons measured from the heavy-ion collision data.The nature of f was found to be smooth and monotonic as a function of the beam energy.Therefore,we conclude that extrapolation from limited p_(T)ranges does not create,enhance,or reduce the local peak of the N_(t)N_(p)/N_(d)^(2)ratio in the beam energy.Our study provides a necessary benchmark for light nuclei ratios as a probe for nucleon density fluctuations,an important observation in the search for the critical point of nuclear matter.
文摘Lipid nanoparticles(LNPs)have emerged as versatile carriers for the delivery of genetic medicines and small-molecule drugs,offering desired benefits for therapeutic applications.Optimization of the treatment efficacy of nanocarriers necessitates a thorough understanding of the connection between pharmacokinetics and physicochemical properties.This review consolidates scientific efforts to elucidate how LNP’s physicochemical attributes influence their in vivo fate,emphasizing particle size and shape,surface electric potential and ligand-binding chemistry.By examining the interplay between LNPs and biological barriers across various administration routes,this review provides insights into tailoring LNP properties for optimal delivery and reduced off-target effects.Recommendations for future research are provided to advance the study of LNP in vivo behaviors and offer a practical framework for optimizing in vivo performance through product design parameters.
基金supported by Research Supporting Project Number(RSPD2025R585),King Saud University,Riyadh,Saudi Arabia.
文摘The liver is a crucial gland and the second-largest organ in the human body and also essential in digestion,metabolism,detoxification,and immunity.Liver diseases result from factors such as viral infections,obesity,alcohol consumption,injuries,or genetic predispositions.Pose significant health risks and demand timely diagnosis and treatment to enhance survival rates.Traditionally,diagnosing liver diseases relied heavily on clinical expertise,often leading to subjective,challenging,and time-intensive processes.However,early detection is essential for effective intervention,and advancements in machine learning(ML)have demonstrated remarkable success in predicting various conditions,including Chronic Obstructive Pulmonary Disease(COPD),hypertension,and diabetes.This study proposed a novel XGBoost-liver predictor by integrating distinct feature methodologies,including Ranking and Statistical Projection-based strategies to detect early signs of liver disease.The Fisher score method is applied to perform global interpretation analysis,helping to select optimal features by assessing their contributions to the overall model.The performance of the proposed model has been extensively evaluated through k-fold cross-validation tests.Firstly,the performance of the proposed model is evaluated using individual and hybrid features.Secondly,the XGBoost-Liver model performance is compared to that of commonly used classifier algorithms.Thirdly,its performance is compared with the existing state-of-the-art computational models.The experimental results show that the proposed model performed better than the existing predictors,reaching an average accuracy rate of 92.07%.This paper demonstrates the potential of machine learning to improve liver disease prediction,enhance diagnostic accuracy,and enable timely medical interventions for better patient outcomes.
基金supported by research funding provided by Arm&Hammer Animal and Food Production,Waukesha,WI 53186,USA.
文摘Background Body weight is an important indicator of the overall health and production efficiency in broiler chickens.In broiler houses,body weight of chicks is variable despite the same genetics,hatching and feeding practices within a production system.The objective of this study was to investigate the intestinal microbiota and bile salt hydrolase(BSH)activity in slow and fast growing broiler chickens,which belonged to the 10th and 90th percentile body weight groups,respectively.Methods A total of 300 Ross 308 broiler chickens(100 per cohort from three independent cohorts)were selected and mucosal samples from the jejunum,ileum,and cecum were collected at day of arrival,11 and 25(n=450).Then,bacterial counts,16S rRNA amplicon sequencing,species specific real-time qPCR,as well as BSH activity were analyzed.Results Results of bacterial counts showed no significant difference between slow and fast growing cohorts(P>0.05),but they tended to be higher in the slow growing chickens in all measured bacterial groups in cecum.The 16S rRNA amplicon sequencing revealed higher relative abundance of E.coli-Shigella(71.3%−79.8%)at day of arrival,while the most abundant microorganisms at d 25 was Candidatus Arthromitus(slow:44.5%;fast:27.4%)in small intestine.qPCR results indicated significant differences in bacterial populations between the slow and fast growing chickens,especially higher total bacteria,Enterococcus,and Clostridium cluster I in the slow growing chickens at d 25.BSH activity was higher in the slow growing chickens than the fast growing chickens[slow:0.476ΔOD/protein(μg/mL);fast:0.258ΔOD/protein(μg/mL);P<0.0001],and correlation analysis highlighted associations between BSH activity,body weight,feed intake,body weight gain,and bacterial counts.Conclusions We postulate that high total bacteria and Enterococcus abundance are associated with high BSH activity,impacting low feed intake and body weight gain,ultimately resulting in separation into slow and fast growing birds.The findings of this study contribute to understanding the relationship between gut microbiota,BSH activity,and host physiology in broiler chickens,with potential implications for poultry production.
基金financially supported by the Fundamental Research Funds for the Central Universities(No.KVJBMC23001536)Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing(No.20240518)+2 种基金the State Key Laboratory of Molecular Engineering of Polymers(Fudan University)(No.K2024-15)the Central Universities support from Beijing Jiaotong University(No.KVYJS24011536)the National Natural Science Foundation of China(No.62175012).
文摘Due to the rapid development and potential applications of iron(Ⅲ)-alginate(Fe-Alg)microgels in biomedical as well as environmental engineering,this study explores the preparation and characterization of spherical Fe-Alg microgels using droplet microfluidics combined with an external ionic crosslinking method.This study focused on the role of Fe^(3+)and examined its effects on the physical/chemical properties of microgels under different ionic conditions and reduced or oxidized states.The pH-dependent release behavior of Fe^(3+)from these microgels demonstrates their potential biomedical and environmental applications.Furthermore,the microgels can exhibit magnetism simply by utilizing in situ oxidation,which can be further used for targeted drug delivery and magnetic separation technologies.
基金supported by the National Natural Science Foundation of China(U2268215,41901074,42501162,and U21A2012)the Second Tibetan Plateau Scientific Expedition and Research Program(2019QZKK0905)+2 种基金the State Key Laboratory of Subtropical Building and Urban Science(2023ZB13)Guangdong Basic and Applied Basic Research Foundation(2024A1515030027)the Guangdong Provincial Key Laboratory of Modern Civil Engineering Technology(2021B1212040003).
文摘Permafrost degradation under climate warming plays a crucial role in hydrological and ecological processes,including the regional water cycle and terrestrial carbon balance.The Tibetan Plateau(TP),which contains the largest expanse of high-altitude permafrost globally,remains understudied in terms of how permafrost degradation affects surface water resources and regional carbon dynamics.Using permafrost simulation models and quantitative analysis,we assess the spatiotemporal impacts of permafrost degradation on surface water resources and carbon dynamics.In the inner endorheic regions of the TP,ground ice meltwater contributed 12.6%of the total lake volume increase from 2000 to 2020,accelerating lake expansion and affecting nearby infrastructure and ecosystems.Cryospheric meltwater accounted for 4.6%of total runoff in the source areas of the Yangtze,Yellow,Lancang,Yarlung Zangbo,and Nujiang Rivers in 2002-2018.This cryospheric meltwater contribution is projected to peak in the 2030s-2040s,followed by a decline,with potentially profound implications for downstream water availability.From 2000 to 2020,carbon sequestration of alpine grassland in permafrost regions is 1.05-1.29 Tg C a^(-1)in 2000-2020.This estimate is underestimated by approximately 35.5%to 48.1%without considering the impact of permafrost degradation.Top-down thawing of permafrost from 2002 to 2050 is projected to release 129.39±21.02 Tg C a^(-1)of thawed soil organic carbon(SOC),with 20.82±3.06 Tg C a^(-1)decomposed annually.Additionally,permafrost collapse and thermokarst lake are estimated to reduce ecosystem carbon sinks by 0.41(0.29-0.52)Tg C a^(-1)in 2020.
基金the financial support from the Science, Technology, and Innovation Funding Authority (STIFA, STDF previously) through project number 42691 entitled “Microstructure-Based, Multi-Physics Simulation and Optimization to Improve Battery Performance”supported by the U.S. DOE (Department of Energy), Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357supported by the U.S. DOE Vehicle Technologies office, under contract number DE-AC02-06CH11357
文摘This study investigates the electrochemical behavior of molybdenum disulfide(MoS_(2))as an anode in Li-ion batteries,focusing on the extra capacity phenomenon.Employing advanced characterization methods such as in situ and ex situ X-ray diffraction,Raman spectroscopy,X-ray photoelectron spectroscopy,and transmission electron microscopy,the research unravels the complex structural and chemical evolution of MoS_(2) throughout its cycling.A key discovery is the identification of a unique Li intercalation mechanism in MoS_(2),leading to the formation of reversible Li_(2)MoS_(2) phases that contribute to the extra capacity of the MoS_(2) electrode.Density function theory calculations suggest the potential for overlithiation in MoS_(2),predicting Li5MoS_(2) as the most energetically favorable phase within the lithiation–delithiation process.Additionally,the formation of a Li-rich phase on the surface of Li_(4)MoS_(2) is considered energetically advantageous.After the first discharge,the battery system engages in two main reactions.One involves operation as a Li-sulfur battery within the carbonate electrolyte,and the other is the reversible intercalation and deintercalation of Li in Li_(2)MoS_(2).The latter reaction contributes to the extra capacity of the battery.The incorporation of reduced graphene oxide as a conductive additive in MoS_(2) electrodes notably improves their rate capability and cycling stability.
基金supported by the Knowledge Innovation Program of Wuhan-Shuguang Project(Project No:2022020801020233)the Key R&D Program of Wuhan City in China(2023020402010600).
文摘Interfacial modular assemblies of versatile polyphenols have attracted widespread interest in surface and materials engineering.In this study,natural polyphenol(tannic acid,TA)and nobiletin(NOB)can directly form binary carrier-free spherical nanoparticles(NT NPs)through synergistically driven by a variety of interactions(such as hydrogen bonding,oxidative reactions,etc.).The synthesis involves polyphenolic deposition on hydrophobic NOB nanoaggregates,followed by in situ oxidative self-polymerization.Interestingly,the assembled NT NPs exhibit controllable and dynamic changes in particle size during the initial stage.Ultimately,uniform and spherical NT NPs appear stable,with high loading capability,enabling incorporated NOB to preserve their function.Furthermore,in vitro evaluations demonstrate that the rational combination of polyphenol module and NOB can induce apoptosis and inhibit tumor metastasis for both lung cancer H1299 and human fibrosarcoma HT1080 cell lines.Notably,the optimized NT48 NPs were then verified in vivo experiments to achieve a promising synergistic anti-tumor efficacy.These findings not only provide new opportunities for the streamlined and sensible engineering of future polyphenol-based biomaterials,but also open up new prospects for the design of smallmolecule nature phytochemicals.
